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Information on EC 6.2.1.66 - glyine---[glycyl-carrier protein] ligase

for references in articles please use BRENDA:EC6.2.1.66

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IUBMB Comments

The adenylation domain of the enzyme catalyses the activation of glycine to (glycyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of a peptidyl-carrier protein domain. The peptidyl-carrier protein domain may be part of the same protein (as in the case of DhbF in bacillibactin biosynthesis), or of a different protein. This activity is often found as part of a larger non-ribosomal peptide synthase.

The enzyme appears in viruses and cellular organisms
  • 6.2.1.66
  • polyketide
  • synthetases
  • siderophore
  • nrpss
  • lipopeptide
  • thioesterase
  • peptidyl
  • depsipeptide
  • phosphopantetheinylated
  • nonproteinogenic
  • multimodular
  • roseosporus
  • ketosynthase
  • cyclodepsipeptide
  • 2,3-dihydroxybenzoate
  • enterobactin
  • cereulide
  • trimodular
  • nrps-pk
  • marfey
  • pks-nrps
  • halogenase
  • tyrocidine
  • a-domains
  • daptomycin
  • mbth
  • nrps-like
  • yersiniabactin
  • thiazoline
Reaction Schemes
hide(Overall reactions are displayed. Show all >>)
+
+
holo-[glycyl-carrier protein]
=
+
+
glycyl-[glycyl-carrier protein]

Synonyms
nonribosomal peptide synthetase, dimodular nrps, dimodular nonribosomal peptide synthetase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(glycyl)adenylate + holo-[glycyl-carrier protein] = AMP + glycyl-[glycyl-carrier protein]
show the reaction diagram
(1b)
-
-
-
ATP + glycine + holo-[glycyl-carrier protein] = AMP + diphosphate + glycyl-[glycyl-carrier protein]
show the reaction diagram
overall reaction
-
-
-
ATP + glycine = diphosphate + (glycyl)adenylate
show the reaction diagram
(1a)
-
-
-
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