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Information on EC 6.2.1.65 - salicylate-CoA ligase

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EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.65 salicylate-CoA ligase
IUBMB Comments
The enzyme, characterized from the bacteria Thauera aromatica and Streptomyces sp. WA46, participates in a salicylate degradation pathway. It activates salicylate by its adenylation to (2-hydroxybenzoyl)adenylate, followed by the transfer of the activated compound to coenzyme A.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
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Synonyms
2-hydroxybenzoate-CoA ligase, salicylyl-CoA synthase/salicylate adenylyltransferase, sdgA, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2-hydroxybenzoyl)adenylate + CoA = AMP + 2-hydroxybenzoyl-CoA
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(1b)
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0
ATP + salicylate + CoA = AMP + diphosphate + 2-hydroxybenzoyl-CoA
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overall reaction
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ATP + salicylate = diphosphate + (2-hydroxybenzoyl)adenylate
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(1a)
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0
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