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Information on EC 6.2.1.61 - salicylate-[aryl-carrier protein] ligase

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EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.61 salicylate-[aryl-carrier protein] ligase
IUBMB Comments
The enzyme catalyses the activation of salicylate to (salicyl)adenylate, followed by the transfer of the activated compound to the free thiol of a phosphopantetheine arm of an aryl-carrier protein, which is often a domain of a larger non-ribosimal peptide synthase. The PmsE enzyme is involved in pseudomonine biosynthesis and transfers the activated salicylate first to itself, and then to a PmsG protein. The PchD enzyme is involved in pyochelin biosynthesis and transfers the activated salicylate directly to the PchE protein.
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The expected taxonomic range for this enzyme is: Pseudomonas
Reaction Schemes
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+
holo-[non-ribosomal peptide synthase]
=
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salicyl-[non-ribosomal peptide synthase]
Synonyms
salicyl-amp ligase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(salicyl)adenylate + holo-[non-ribosomal peptide synthase] = AMP + salicyl-[non-ribosomal peptide synthase]
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(1b)
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0
ATP + salicylate + holo-[non-ribosomal peptide synthase] = AMP + diphosphate + salicyl-[non-ribosomal peptide synthase]
show the reaction diagram
overall reaction
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0
ATP + salicylate = diphosphate + (salicyl)adenylate
show the reaction diagram
(1a)
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0
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