Information on EC 6.2.1.59 - long-chain fatty acid adenylase/transferase FadD26

for references in articles please use BRENDA:EC6.2.1.59
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EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.59 long-chain fatty acid adenylase/transferase FadD26
IUBMB Comments
The enzyme, present in pathogenic species of mycobacteria, participates in the pathway for biosynthesis of phthiocerols. It catalyses the adenylation of the long-chain fatty acids arachidate (C20) or behenate (C22) and potentially the very-long-chain fatty acid lignocerate (C24) . The activated fatty acids are then loaded to EC 2.3.1.292, (phenol)carboxyphthiodiolenone synthase.
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Word Map
The expected taxonomic range for this enzyme is: Mycobacterium
Reaction Schemes
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holo-[(phenol)carboxyphthiodiolenone synthase]
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a long-chain acyl-[(phenol)carboxyphthiodiolenone synthase]
Synonyms
FadD26, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a long-chain fatty-acyl adenylate ester + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + a long-chain acyl-[(phenol)carboxyphthiodiolenone synthase]
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(1b)
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ATP + a long-chain fatty acid + holo-[(phenol)carboxyphthiodiolenone synthase] = AMP + diphosphate + a long-chain acyl-[(phenol)carboxyphthiodiolenone synthase]
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overall reaction
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ATP + a long-chain fatty acid = diphosphate + a long-chain fatty-acyl adenylate ester
show the reaction diagram
(1a)
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