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Information on EC 6.2.1.57 - long-chain fatty acid adenylase/transferase FadD23

for references in articles please use BRENDA:EC6.2.1.57

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IUBMB Comments

This mycobacterial enzyme activates palmitate and stearate by adenylation, followed by their loading onto the polyketide synthase EC 2.3.1.287, phthioceranic/hydroxyphthioceranic acid synthase.

The expected taxonomic range for this enzyme is: Mycobacteriaceae
Reaction Schemes
hide(Overall reactions are displayed. Show all >>)
+
+
a holo-[(hydroxy)phthioceranic acid synthase]
=
+
+
a stearoyl-[(hydroxy)phthioceranic acid synthase]
+
+
a holo-[(hydroxy)phthioceranic acid synthase]
=
+
+
a palmitoyl-[(hydroxy)phthioceranic acid synthase]

Synonyms
fatty acyl-amp ligase, fadd23, rv3826, fatty-acyl amp ligase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(palmitoyl)adenylate + a holo-[(hydroxy)phthioceranic acid synthase] = AMP + a palmitoyl-[(hydroxy)phthioceranic acid synthase]
show the reaction diagram
(2b)
-
-
-
(stearoyl)adenylate + a holo-[(hydroxy)phthioceranic acid synthase] = AMP + a stearoyl-[(hydroxy)phthioceranic acid synthase]
show the reaction diagram
(1b)
-
-
-
ATP + palmitate + a holo-[(hydroxy)phthioceranic acid synthase] = AMP + diphosphate + a palmitoyl-[(hydroxy)phthioceranic acid synthase]
show the reaction diagram
overall reaction
-
-
-
ATP + palmitate = diphosphate + (palmitoyl)adenylate
show the reaction diagram
(2a)
-
-
-
ATP + stearate + a holo-[(hydroxy)phthioceranic acid synthase] = AMP + diphosphate + a stearoyl-[(hydroxy)phthioceranic acid synthase]
show the reaction diagram
overall reaction
-
-
-
ATP + stearate = diphosphate + (stearoyl)adenylate
show the reaction diagram
(1a)
-
-
-
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