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Information on EC 6.2.1.57 - long-chain fatty acid adenylase/transferase FadD23

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EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.57 long-chain fatty acid adenylase/transferase FadD23
IUBMB Comments
This mycobacterial enzyme activates palmitate and stearate by adenylation, followed by their loading onto the polyketide synthase EC 2.3.1.287, phthioceranic/hydroxyphthioceranic acid synthase.
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Word Map
The expected taxonomic range for this enzyme is: Mycobacteriaceae
Reaction Schemes
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a holo-[(hydroxy)phthioceranic acid synthase]
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a stearoyl-[(hydroxy)phthioceranic acid synthase]
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a holo-[(hydroxy)phthioceranic acid synthase]
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a palmitoyl-[(hydroxy)phthioceranic acid synthase]
Synonyms
FAAL, fadD23, fatty acyl-AMP ligase, fatty-acyl AMP ligase, long-chain fatty acid adenylyltransferase FadD23, Rv3826, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(palmitoyl)adenylate + a holo-[(hydroxy)phthioceranic acid synthase] = AMP + a palmitoyl-[(hydroxy)phthioceranic acid synthase]
show the reaction diagram
(2b)
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0
(stearoyl)adenylate + a holo-[(hydroxy)phthioceranic acid synthase] = AMP + a stearoyl-[(hydroxy)phthioceranic acid synthase]
show the reaction diagram
(1b)
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0
ATP + palmitate + a holo-[(hydroxy)phthioceranic acid synthase] = AMP + diphosphate + a palmitoyl-[(hydroxy)phthioceranic acid synthase]
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overall reaction
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ATP + palmitate = diphosphate + (palmitoyl)adenylate
show the reaction diagram
(2a)
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ATP + stearate + a holo-[(hydroxy)phthioceranic acid synthase] = AMP + diphosphate + a stearoyl-[(hydroxy)phthioceranic acid synthase]
show the reaction diagram
overall reaction
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0
ATP + stearate = diphosphate + (stearoyl)adenylate
show the reaction diagram
(1a)
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0
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