Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

show all | hide all No of entries

Information on EC 6.2.1.57 - long-chain fatty acid adenylase/transferase FadD23

for references in articles please use BRENDA:EC6.2.1.57
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.57 long-chain fatty acid adenylase/transferase FadD23
IUBMB Comments
This mycobacterial enzyme activates palmitate and stearate by adenylation, followed by their loading onto the polyketide synthase EC 2.3.1.287, phthioceranic/hydroxyphthioceranic acid synthase.
Specify your search results
Select one or more organisms in this record: ?
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
hide(Overall reactions are displayed. Show all >>)
+
+
a holo-[(hydroxy)phthioceranic acid synthase]
=
+
+
a stearoyl-[(hydroxy)phthioceranic acid synthase]
+
+
a holo-[(hydroxy)phthioceranic acid synthase]
=
+
+
a palmitoyl-[(hydroxy)phthioceranic acid synthase]
Synonyms
fatty acyl-amp ligase, fadd23, rv3826, fatty-acyl amp ligase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(palmitoyl)adenylate + a holo-[(hydroxy)phthioceranic acid synthase] = AMP + a palmitoyl-[(hydroxy)phthioceranic acid synthase]
show the reaction diagram
(2b)
-
-
-
(stearoyl)adenylate + a holo-[(hydroxy)phthioceranic acid synthase] = AMP + a stearoyl-[(hydroxy)phthioceranic acid synthase]
show the reaction diagram
(1b)
-
-
-
ATP + palmitate + a holo-[(hydroxy)phthioceranic acid synthase] = AMP + diphosphate + a palmitoyl-[(hydroxy)phthioceranic acid synthase]
show the reaction diagram
overall reaction
-
-
-
ATP + palmitate = diphosphate + (palmitoyl)adenylate
show the reaction diagram
(2a)
-
-
-
ATP + stearate + a holo-[(hydroxy)phthioceranic acid synthase] = AMP + diphosphate + a stearoyl-[(hydroxy)phthioceranic acid synthase]
show the reaction diagram
overall reaction
-
-
-
ATP + stearate = diphosphate + (stearoyl)adenylate
show the reaction diagram
(1a)
-
-
-
Select items on the left to see more content.