Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Information on EC 6.2.1.54 - D-alanine-[D-alanyl-carrier protein] ligase

for references in articles please use BRENDA:EC6.2.1.54

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

The enzyme is involved in the modification of wall teichoic acids, as well as type I and IV lipoteichoic acids, with D-alanine residues. It activates D-alanine using ATP to form a high-energy (D-alanyl)adenylate intermediate and subsequently transfers the alanyl moiety to the phosphopantheinyl prosthetic group of a D-alanyl-carrier protein (DltC).

The enzyme appears in viruses and cellular organisms
Reaction Schemes
hide(Overall reactions are displayed. Show all >>)
+
+
holo-[D-alanyl-carrier protein]
=
+
+
D-alanyl-[D-alanyl-carrier protein]

Synonyms
d-alanyl carrier protein ligase, d-alanine:d-alanyl carrier protein ligase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(D-alanyl)adenylate + holo-[D-alanyl-carrier protein] = AMP + D-alanyl-[D-alanyl-carrier protein]
show the reaction diagram
(1b)
-
-
-
ATP + D-alanine + holo-[D-alanyl-carrier protein] = AMP + diphosphate + D-alanyl-[D-alanyl-carrier protein]
show the reaction diagram
overall reaction
-
-
-
ATP + D-alanine = (D-alanyl)adenylate + diphosphate
show the reaction diagram
(1a)
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -, -
Highest Expressing Human Cell Lines
Cell Line Links Gene Links