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Information on EC 6.2.1.54 - D-alanine-[D-alanyl-carrier protein] ligase

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EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.54 D-alanine-[D-alanyl-carrier protein] ligase
IUBMB Comments
The enzyme is involved in the modification of wall teichoic acids, as well as type I and IV lipoteichoic acids, with D-alanine residues. It activates D-alanine using ATP to form a high-energy (D-alanyl)adenylate intermediate and subsequently transfers the alanyl moiety to the phosphopantheinyl prosthetic group of a D-alanyl-carrier protein (DltC).
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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holo-[D-alanyl-carrier protein]
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D-alanyl-[D-alanyl-carrier protein]
Synonyms
BcDltA, D-alanine:D-alanyl carrier protein ligase, D-alanine–D-alanyl carrier protein ligase, D-alanyl carrier protein ligase, Dcl, DltA, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(D-alanyl)adenylate + holo-[D-alanyl-carrier protein] = AMP + D-alanyl-[D-alanyl-carrier protein]
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(1b)
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0
ATP + D-alanine + holo-[D-alanyl-carrier protein] = AMP + diphosphate + D-alanyl-[D-alanyl-carrier protein]
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overall reaction
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0
ATP + D-alanine = (D-alanyl)adenylate + diphosphate
show the reaction diagram
(1a)
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0
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