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Information on EC 6.2.1.53 - L-proline-[L-prolyl-carrier protein] ligase

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EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.53 L-proline-[L-prolyl-carrier protein] ligase
IUBMB Comments
The enzyme participates in the biosynthesis of several pyrrole-containing compounds, such as undecylprodigiosin, prodigiosin, pyoluteorin, and coumermycin A1. It catalyses the activation of L-proline to an adenylate form, followed by its transfer to the 4'-phosphopantheine moiety of an L-prolyl-carrier protein.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
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holo-[L-prolyl-carrier protein]
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L-prolyl-[L-prolyl-carrier protein]
Synonyms
l-prolyl-amp ligase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(L-prolyl)adenylate + holo-[L-prolyl-carrier protein] = AMP + L-prolyl-[L-prolyl-carrier protein]
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(1b)
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0
ATP + L-proline + holo-[L-prolyl-carrier protein] = AMP + diphosphate + L-prolyl-[L-prolyl-carrier protein]
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overall reaction
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ATP + L-proline = diphosphate + (L-prolyl)adenylate
show the reaction diagram
(1a)
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0
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