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Information on EC - L-firefly luciferin-CoA ligase

for references in articles please use BRENDA:EC6.2.1.52
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EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
       L-firefly luciferin-CoA ligase
IUBMB Comments
This is an alternative activity of the firefly luciferase (EC, which the enzyme exhibits under normal conditions only when acting on the L-enantiomer of its substrate. The D-isomer can act as a substrate for the CoA---ligase activity in vitro only under low oxygen conditions that are not found in vivo. The activation of L-firefly luciferin to a CoA ester is a step in a recycling pathway that results in its epimerization to the D enantiomer, which is the only substrate whose oxygenation results in light emission.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
firefly luciferase, long-chain fattyacyl-CoA synthetase, Luc, LUC-G, LUC-H, luciferyl-CoA synthetase, protoluciferase, more
ATP + L-firefly luciferin + CoA = AMP + diphosphate + L-firefly luciferyl-CoA
show the reaction diagram
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