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Information on EC 6.2.1.52 - L-firefly luciferin-CoA ligase

for references in articles please use BRENDA:EC6.2.1.52

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IUBMB Comments

This is an alternative activity of the firefly luciferase (EC 1.13.12.7), which the enzyme exhibits under normal conditions only when acting on the L-enantiomer of its substrate. The D-isomer can act as a substrate for the CoA—ligase activity in vitro only under low oxygen conditions that are not found in vivo. The activation of L-firefly luciferin to a CoA ester is a step in a recycling pathway that results in its epimerization to the D enantiomer, which is the only substrate whose oxygenation results in light emission.

The enzyme appears in viruses and cellular organisms

Synonyms
protoluciferase, luciferyl-coa synthetase, luc-g, luc-h, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + L-firefly luciferin + CoA = AMP + diphosphate + L-firefly luciferyl-CoA
show the reaction diagram
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