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IUBMB CommentsThe enzyme ligates medium chain fatty acids (with aliphatic chain of 6-12 carbons) to an acyl-carrier protein.
The enzyme appears in viruses and cellular organisms
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jamA
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ATP + a medium-chain fatty acid + a holo-[acyl-carrier protein] = AMP + diphosphate + a medium-chain acyl-[acyl-carrier protein]
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medium-chain-fatty-acid:[acyl-carrier protein] ligase (AMP-forming)
The enzyme ligates medium chain fatty acids (with aliphatic chain of 6-12 carbons) to an acyl-carrier protein.
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ATP + hex-5-enoic acid + a holo-[acyl-carrier protein]
AMP + diphosphate + hex-5-enoyl-[acyl-carrier protein]
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ATP + hex-5-ynoic acid + a holo-[acyl-carrier protein]
AMP + diphosphate + hex-5-ynoyl-[acyl-carrier protein]
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UniProt
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Edwards, D.J.; Marquez, B.L.; Nogle, L.M.; McPhail, K.; Goeger, D.E.; Roberts, M.A.; Gerwick, W.H.
Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula
Chem. Biol.
11
817-33
2004
Lyngbya majuscula (Q6E7K9)
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