Reference on EC 6.2.1.45 - E1 ubiquitin-activating enzyme
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hatfield, P.M.; Gosink, M.M.; Carpenter, T.B.; Vierstra, R.D.
The ubiquitin-activating enzyme (E1) gene family in Arabidopsis thaliana
Plant J.
11
213-226
1997
Arabidopsis thaliana (P92974), Arabidopsis thaliana (P93028), Arabidopsis thaliana
Handley, P.M.; Mueckler, M.; Siegel, N.R.; Ciechanover, A.; Schwartz, A.I.
Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1
Proc. Natl. Acad. Sci. USA
88
258-262
1991
Homo sapiens (P22314), Homo sapiens
Yang, Y.; Kitagaki, J.; Dai, R.M.; Tsai, Y.C.; Lorick, K.L.; Ludwig, R.L.; Pierre, S.A.; Jensen, J.P.; Davydov, I.V.; Oberoi, P.; Li, C.C.; Kenten, J.H.; Beutler, J.A.; Vousden, K.H.; Weissman, A.M.
Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics
Cancer Res.
67
9472-9481
2007
Homo sapiens, Mus musculus
Tokgoez, Z.; Bohnsack, R.N.; Haas, A.L.
Pleiotropic effects of ATP*Mg2+ binding in the catalytic cycle of ubiquitin-activating enzyme
J. Biol. Chem.
281
14729-14737
2006
Homo sapiens
Pelzer, C.; Kassner, I.; Matentzoglu, K.; Singh, R.K.; Wollscheid, H.P.; Scheffner, M.; Schmidtke, G.; Groettrup, M.
UBE1L2, a novel E1 enzyme specific for ubiquitin
J. Biol. Chem.
282
23010-23014
2007
Homo sapiens, Homo sapiens (A0AVT1), Mus musculus
Nouspikel, T.; Hanawalt, P.C.
Impaired nucleotide excision repair upon macrophage differentiation is corrected by E1 ubiquitin-activating enzyme
Proc. Natl. Acad. Sci. USA
103
16188-16193
2006
Homo sapiens
Pfleger, C.M.; Harvey, K.F.; Yan, H.; Hariharan, I.K.
Mutation of the gene encoding the ubiquitin activating enzyme Uba1 causes tissue overgrowth in Drosophila
Fly
1
95-105
2008
Drosophila melanogaster
Zheng, M.; Gu, X.; Zheng, D.; Yang, Z.; Li, F.; Zhao, J.; Xie, Y.; Ji, C.; Mao, Y.
UBE1DC1, an ubiquitin-activating enzyme, activates two different ubiquitin-like proteins
J. Cell. Biochem.
104
2324-2334
2008
Homo sapiens (Q9GZZ9)
Xu, G.W.; Ali, M.; Wood, T.E.; Wong, D.; Maclean, N.; Wang, X.; Gronda, M.; Skrtic, M.; Li, X.; Hurren, R.; Mao, X.; Venkatesan, M.; Beheshti Zavareh, R.; Ketela, T.; Reed, J.C.; Rose, D.; Moffat, J.; Batey, R.A.; Dhe-Paganon, S.; Schimmer, A.D.
The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma
Blood
115
2251-2259
2010
Homo sapiens, Mus musculus
Bacik, J.P.; Walker, J.R.; Ali, M.; Schimmer, A.D.; Dhe-Paganon, S.
Crystal structure of the human ubiquitin-activating enzyme 5 (UBA5) bound to ATP: mechanistic insights into a minimalistic E1 enzyme
J. Biol. Chem.
285
20273-20280
2010
Homo sapiens (Q9GZZ9), Homo sapiens
Brahemi, G.; Burger, A.M.; Westwell, A.D.; Brancale, A.
Homology modelling of human E1 ubiquitin activating enzyme
Lett. Drug Des. Discov.
7
57-62
2010
Homo sapiens (P22314), Homo sapiens
Zheng, M.; Liu, J.; Yang, Z.; Gu, X.; Li, F.; Lou, T.; Ji, C.; Mao, Y.
Expression, purification and characterization of human ubiquitin-activating enzyme, UBE1
Mol. Biol. Rep.
37
1413-1419
2010
Homo sapiens, Homo sapiens (Q712V1)
Lao, T.; Chen, S.; Sang, N.
Two mutations impair the stability and function of ubiquitin-activating enzyme (E1)
J. Cell. Physiol.
227
1451-1458
2012
Mus musculus
Huzil, J.T.; Pannu, R.; Ptak, C.; Garen, G.; Ellison, M.J.
Direct catalysis of lysine 48-linked polyubiquitin chains by the ubiquitin-activating enzyme
J. Biol. Chem.
282
37454-37460
2007
Escherichia coli
Jaremko, M.; Jaremko, L.; Nowakowski, M.; Wojciechowski, M.; Szczepanowski, R.H.; Panecka, R.; Zhukov, I.; Bochtler, M.; Ejchart, A.
NMR structural studies of the first catalytic half-domain of ubiquitin activating enzyme
J. Struct. Biol.
185
69-78
2014
Mus musculus (Q02053), Mus musculus
Carvalho, A.F.; Pinto, M.P.; Grou, C.P.; Vitorino, R.; Domingues, P.; Yamao, F.; Sa-Miranda, C.; Azevedo, J.E.
High-yield expression in Escherichia coli and purification ofmouse ubiquitin-activating enzyme E1
Mol. Biotechnol.
51
254-261
2012
Mus musculus
Salvat, C.; Acquaviva, C.; Scheffner, M.; Robbins, I.; Piechaczyk, M.; Jariel-Encontre, I.
Molecular characterization of the thermosensitive E1 ubiquitin-activating enzyme cell mutant A31N-ts20. Requirements upon different levels of E1 for the ubiquitination/degradation of the various protein substrates in vivo
Eur. J. Biochem.
267
3712-3722
2000
Mus musculus
Swanson, R.; Hochstrasser, M.
A viable ubiquitin-activating enzyme mutant for evaluating ubiquitin system function in Saccharomyces cerevisiae
FEBS Lett.
477
193-198
2000
Saccharomyces cerevisiae
Lu, X.; Olsen, S.K.; Capili, A.D.; Cisar, J.S.; Lima, C.D.; Tan, D.S.
Designed semisynthetic protein inhibitors of Ub/Ubl E1 activating enzymes
J. Am. Chem. Soc.
17
1748-1749
2010
Schizosaccharomyces pombe
Pickart, C.M.; Kasperek, E.M.; Beal, R.; Kim, A.
Substrate properties of site-specific mutant ubiquitin protein (G76A) reveal unexpected mechanistic features of ubiquitin-activating enzyme (E1)
J. Biol. Chem.
269
7115-7123
1994
Bos taurus
Lao, T.; Chen, S.; Sang, N.
Two mutations impair the stability and function of ubiquitin-activating enzyme (E1)
J. Cell. Physiol.
227
1561-1568
2012
Mus musculus
Wee, K.E.; Lai, Z.; Auger, K.R.; Ma, J.; Horiuchi, K.Y.; Dowling, R.L.; Dougherty, C.S.; Corman, J.I.; Wynn, R.; Copeland, R.A.
Steady-state kinetic analysis of human ubiquitin-activating enzyme (E1) using a fluorescently labeled ubiquitin substrate
J. Protein Chem.
19
489-498
2000
Homo sapiens
Wang, J.; Taherbhoy, A.M.; Hunt, H.W.; Seyedin, S.N.; Miller, D.W., Miller, D.J.; Huang, D.T.; Schulman, B.A.
Crystal structure of UBA2ufd-Ubc9: Insights into E1-E2 interactions in Sumo pathways
PLoS ONE
1
e15805
2010
Saccharomyces cerevisiae (P52488), Saccharomyces cerevisiae
Nino, C.A.; Prucca, C.G.; Chaparro, J.; Lujan, H.D.; Wasserman, M.
The ubiquitin-activating enzyme (E1) of the early-branching eukaryote Giardia intestinalis shows unusual proteolytic modifications and play important roles during encystation
Acta Trop.
123
39-46
2012
Giardia intestinalis (A8BBP6), Giardia intestinalis, Giardia intestinalis ATCC 50803 (A8BBP6)
Nakayama, T.; Yuasa, E.; Kanemaru, A.; Saito, M.; Saitoh, H.
Construction of a mouse Aos1-Uba2 chimeric SUMO-E1 enzyme, mAU, and its expression in baculovirus-insect cells
Bioengineered
5
133-137
2014
Mus musculus
Xie, S.T.
Expression, purification, and crystal structure of N-terminal domains of human ubiquitin-activating enzyme (E1)
Biosci. Biotechnol. Biochem.
78
1542-1549
2014
Homo sapiens (P22314), Homo sapiens
Miao, H.X.; Qin, Y.H.; Ye, Z.X.; Hu, G.B.
Molecular characterization and expression analysis of ubiquitin-activating enzyme E1 gene in Citrus reticulata
Gene
513
249-259
2013
Citrus reticulata
Chang, T.; Huang, Y.; Ou, Y.
The role of ginsenosides in inhibiting ubiquitin activating enzyme (E1) activity
J. Funct. Foods
7
462-470
2014
Homo sapiens
-
Zhu, Z.; Yang, F.; Zhang, K.; Cao, W.; Jin, Y.; Wang, G.; Mao, R.; Li, D.; Guo, J.; Liu, X.; Zheng, H.
Comparative proteomic analysis of wild-type and SAP domain-mutant Foot-and-mouth disease virus (FMDV)-infected porcine cells identifies the ubiquitin-activating enzyme UBE1 required for virus replication
J. Proteome Res.
14
4194-4206
2015
Sus scrofa
Bialas, J.; Groettrup, M.; Aichem, A.
Conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 targets it for proteasomal degradation
PLoS ONE
10
e0120329
2015
Homo sapiens
Ungermannova, D.; Parker, S.J.; Nasveschuk, C.G.; Wang, W.; Quade, B.; Zhang, G.; Kuchta, R.D.; Phillips, A.J.; Liu, X.
Largazole and its derivatives selectively inhibit ubiquitin activating enzyme (E1)
PLoS ONE
7
e29208
2012
Homo sapiens, Schizosaccharomyces pombe
Liu, H.Y.; Pfleger, C.M.
Mutation in E1, the ubiquitin activating enzyme, reduces Drosophila lifespan and results in motor impairment
PLoS ONE
8
e32835
2013
Drosophila melanogaster
Qin, Z.; Cui, B.; Jin, J.; Song, M.; Zhou, B.; Guo, H.; Qian, D.; He, Y.; Huang, L.
The ubiquitin-activating enzyme E1 as a novel therapeutic target for the treatment of restenosis
Atherosclerosis
247
142-153
2016
Homo sapiens (P22314)
Wu, C.; Liu, Y.; Gu, X.; Zhu, T.; Yang, S.; Sun, W.
LMO2 blocks the UBA6-USE1 interaction and downstream FAT10ylation by targeting the ubiquitin fold domain of UBA6
Biochem. Biophys. Res. Commun.
478
1442-1448
2016
Homo sapiens (A0AVT1)
Oweis, W.; Padala, P.; Hassouna, F.; Cohen-Kfir, E.; Gibbs, D.R.; Todd, E.A.; Berndsen, C.E.; Wiener, R.
Trans-binding mechanism of ubiquitin-like protein activation revealed by a UBA5-UFM1 complex
Cell Rep.
16
3113-3120
2016
Homo sapiens (Q9GZZ9)
Lu, X.; Malley, K.R.; Brenner, C.C.; Koroleva, O.; Korolev, S.; Downes, B.P.
A MUB E2 structure reveals E1 selectivity between cognate ubiquitin E2s in eukaryotes
Nat. Commun.
7
12580
2016
Arabidopsis thaliana (P92974), Arabidopsis thaliana (P93028)
Liu, X.; Zhao, B.; Sun, L.; Bhuripanyo, K.; Wang, Y.; Bi, Y.; Davuluri, R.; Duong, D.; Nanavati, D.; Yin, J.; Kiyokawa, H.
Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes
Nat. Commun.
8
14286
2017
Homo sapiens (A0AVT1), Homo sapiens (P22314)
Liu, X.; Sun, L.; Gursel, D.B.; Cheng, C.; Huang, S.; Rademaker, A.W.; Khan, S.A.; Yin, J.; Kiyokawa, H.
The non-canonical ubiquitin activating enzyme UBA6 suppresses epithelial-mesenchymal transition of mammary epithelial cells
Oncotarget
8
87480-87493
2017
Homo sapiens (A0AVT1), Homo sapiens
Zhang, L.; Zhao, Z.; Wang, Y.; Li, N.; Cao, N.; Yang, L.
Changes in expression of interferon-stimulated genes and ubiquitin activating enzyme E1-like in ovine thymus during early pregnancy
Anim. Reprod.
17
e20190134
2020
Ovis aries (A0A6P7D3I5), Ovis aries
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