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Information on EC 6.2.1.45 - E1 ubiquitin-activating enzyme
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6.2.1.45 E1 ubiquitin-activating enzymeIUBMB Comments
Catalyses the ATP-dependent activation of ubiquitin through the formation of a thioester bond between the C-terminal glycine of ubiquitin and the sulfhydryl side group of a cysteine residue in the E1 protein. The two-step reaction consists of the ATP-dependent formation of an E1-ubiquitin adenylate intermediate in which the C-terminal glycine of ubiquitin is bound to AMP via an acyl-phosphate linkage, then followed by the conversion to an E1-ubiquitin thioester bond via the cysteine residue on E1 in the second step.
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- 6.2.1.45
- proteasome
-
ubiquitin-proteasome
-
polyubiquitination
- ligases
- ubiquitin-protein
- finger
-
ubiquitin-dependent
-
sumoylation
- isg15
- cdc34
- rad6
-
isgylation
-
ubiquitin-mediated
-
deubiquitinating
-
anaphase-promoting
-
genorm
-
ubiquitin-related
- ubch7
-
normfinder
-
multiubiquitination
- sumo-1
-
nonpermissive
-
proteasome-dependent
-
cullins
- lactacystin
-
bestkeeper
-
ub-conjugating
- thiolester
- nedd8
-
postreplication
-
interferon-stimulated
- peroxins
-
ubiquitin-ligase
-
ring-h2
-
lys63-linked
-
mono-ubiquitination
-
error-free
- sic1
- drug development
- ube2l3
-
translesion
- synthesis
-
cullin-ring
- medicine
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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[E1 ubiquitin-activating enzyme]-L-cysteine
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S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine
Synonyms
ubiquitin-conjugating enzyme, ube1l, ubiquitin-activating enzyme, ubiquitin-activating enzyme e1, ubiquitin-activating enzyme (e1), ubiquitin activating enzyme, sumo e1, e1 ubiquitin-activating enzyme, ubiquitin e1, ubiquitin activating enzyme e1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
ubiquitin:[E1 ubiquitin-activating enzyme] ligase (AMP-forming)
Catalyses the ATP-dependent activation of ubiquitin through the formation of a thioester bond between the C-terminal glycine of ubiquitin and the sulfhydryl side group of a cysteine residue in the E1 protein. The two-step reaction consists of the ATP-dependent formation of an E1-ubiquitin adenylate intermediate in which the C-terminal glycine of ubiquitin is bound to AMP via an acyl-phosphate linkage, then followed by the conversion to an E1-ubiquitin thioester bond via the cysteine residue on E1 in the second step.
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
Proteomic analysis on the alteration of protein expression in the placental villous tissue of early pregnancy loss.
Adenocarcinoma
Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas.
Adenocarcinoma
Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma.
Adenocarcinoma
Expression of the ubiquitin-proteasome pathway and muscle loss in experimental cancer cachexia.
Adenocarcinoma
Silencing ubiquitin-conjugating enzyme 2C inhibits proliferation and epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma.
African Swine Fever
African Swine Fever Virus Ubiquitin-Conjugating Enzyme Interacts With Host Translation Machinery to Regulate the Host Protein Synthesis.
African Swine Fever
African Swine Fever Virus Ubiquitin-Conjugating Enzyme Is an Immunomodulator Targeting NF-?B Activation.
African Swine Fever
Characterization of a ubiquitinated protein which is externally located in African swine fever virions.
Alzheimer Disease
Structure of full-length ubiquitin-conjugating enzyme E2-25K (huntingtin-interacting protein 2).
Atherosclerosis
Induction of ubiquitin-conjugating enzyme by aggregated low density lipoprotein in human macrophages and its implications for atherosclerosis.
Atherosclerosis
Inhibition of the Ubiquitin-Activating Enzyme UBA1 Suppresses Diet-Induced Atherosclerosis in Apolipoprotein E-Knockout Mice.
Atherosclerosis
The rs46522 Polymorphism of the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with Abnormal Metabolic Parameters in Patients with Myocardial Infarction: The Genetics of Atherosclerosis Disease Mexican Study.
Bacterial Infections
Evaluation of housekeeping genes as references for quantitative real time RT-PCR analysis of gene expression in Japanese flounder (Paralichthys olivaceus).
Blast Crisis
De novo UBE2A mutations are recurrently acquired during chronic myeloid leukemia progression and interfere with myeloid differentiation pathways.
Brain Diseases
Biallelic loss-of-function UBA5 mutations in a patient with intractable West syndrome and profound failure to thrive.
Breast Neoplasms
Design, synthesis, and biological evaluation of novel ubiquitin-activating enzyme inhibitors.
Breast Neoplasms
Erratum to: Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-?B mediated matrix metalloproteinase-1 gene regulation.
Breast Neoplasms
Expression of UBE2Q2, a putative member of the ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia.
Breast Neoplasms
Knockdown of UbcH10 Enhances the Chemosensitivity of Dual Drug Resistant Breast Cancer Cells to Epirubicin and Docetaxel.
Breast Neoplasms
MicroRNA-196a post-transcriptionally upregulates the UBE2C proto-oncogene and promotes cell proliferation in breast cancer.
Breast Neoplasms
The clinicopathological significance of UBE2C in breast cancer: a study based on immunohistochemistry, microarray and RNA-sequencing data.
Breast Neoplasms
The clinicopathological significance of ubiquitin-conjugating enzyme E2C, leucine-rich repeated-containing G protein-coupled receptor, WW domain-containing oxidoreductase, and vasculogenic mimicry in invasive breast carcinoma.
Breast Neoplasms
The ubiquitin-conjugating enzyme E2-EPF is overexpressed in primary breast cancer and modulates sensitivity to topoisomerase II inhibition.
Breast Neoplasms
UBE2S is associated with malignant characteristics of breast cancer cells.
Breast Neoplasms
Ubiquitin-activating enzyme is necessary for 17?-estradiol-induced breast cancer cell proliferation and migration.
Breast Neoplasms
Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-[cyrillic small letter ka]B mediated matrix metalloproteinase-1 gene regulation.
Breast Neoplasms
Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade.
Breast Neoplasms
Ubiquitin-Conjugating Enzyme UBE2C Is Highly Expressed in Breast Microcalcification Lesions.
Calcinosis
Ubiquitin-Conjugating Enzyme UBE2C Is Highly Expressed in Breast Microcalcification Lesions.
Carcinogenesis
Down-regulation of epidermal growth factor receptor by curcumin-induced UBE1L in human bronchial epithelial cells.
Carcinogenesis
Hepatitis C Virus Downregulates Ubiquitin-Conjugating Enzyme E2S Expression To Prevent Proteasomal Degradation of NS5A, Leading to Host Cells More Sensitive to DNA Damage.
Carcinogenesis
High expression of UBE2C is associated with the aggressive progression and poor outcome of malignant glioma.
Carcinogenesis
Hypomethylated Ubiquitin-Conjugating Enzyme2 Q1 (UBE2Q1) Gene Promoter in the Serum Is a Promising Biomarker for Hepatitis B Virus-Associated Hepatocellular Carcinoma.
Carcinogenesis
Knockdown of ubiquitin-conjugating enzyme E2C/UbcH10 expression by RNA interference inhibits glioma cell proliferation and enhances cell apoptosis in vitro.
Carcinogenesis
Microarray analyses uncover UBE1L as a candidate target gene for lung cancer chemoprevention.
Carcinogenesis
The expression of ubiquitin-conjugating enzyme E2C and KAI1 in ovarian carcinoma and their clinical significance.
Carcinogenesis
UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo.
Carcinogenesis
UBE2D3 is a positive prognostic factor and is negatively correlated with hTERT expression in esophageal cancer.
Carcinogenesis
Ubiquitin-conjugating enzyme UBE2C: molecular biology, role in tumorigenesis, and potential as a biomarker.
Carcinoma
Cloning and sequence of a functionally active cDNA encoding the mouse ubiquitin-activating enzyme E1.
Carcinoma
Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas.
Carcinoma
Downregulation of Ubiquitin-conjugating Enzyme UBE2D3 Promotes Telomere Maintenance and Radioresistance of Eca-109 Human Esophageal Carcinoma Cells.
Carcinoma
Expression of UBE2Q2, a putative member of the ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia.
Carcinoma
Involvement of ubiquitin-conjugating enzyme E2C in proliferation and invasion of prostate carcinoma cells.
Carcinoma
Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity.
Carcinoma
Sensitization against anticancer drugs by transfection with UBE2I variant gene into ras-NIH3H3 mouse fibroblasts.
Carcinoma
The expression of ubiquitin-conjugating enzyme E2C and KAI1 in ovarian carcinoma and their clinical significance.
Carcinoma
UBE2S associated with OSCC proliferation by promotion of P21 degradation via the ubiquitin-proteasome system.
Carcinoma
Ubiquitin metabolism in ts85 cells, a mouse carcinoma line that contains a thermolabile ubiquitin activating enzyme.
Carcinoma
Up-regulation of interferon-stimulated gene 15 and its conjugation machinery, UbE1L and UbcH8 expression by tumor necrosis factor-? through p38 MAPK and JNK signaling pathways in human lung carcinoma.
Carcinoma
Upregulated expression of ubiquitin-conjugating enzyme E2Q1 (UBE2Q1) is associated with enhanced cell proliferation and poor prognosis in human hapatocellular carcinoma.
Carcinoma, Hepatocellular
High expression of ubiquitin-conjugating enzyme E2A predicts poor prognosis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression.
Carcinoma, Hepatocellular
S-adenosylmethionine regulates ubiquitin-conjugating enzyme 9 protein expression and sumoylation in murine liver and human cancers.
Carcinoma, Hepatocellular
UBE2M promotes cell proliferation via the ?-catenin/cyclin D1 signaling in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Upregulation of ubiquitin-conjugating enzyme E2Z is associated with human hepatocellular carcinoma.
Carcinoma, Non-Small-Cell Lung
Down-regulation of epidermal growth factor receptor by curcumin-induced UBE1L in human bronchial epithelial cells.
Carcinoma, Non-Small-Cell Lung
Ubiquitin-conjugating enzyme E2C regulates apoptosis-dependent tumor progression of non-small cell lung cancer via ERK pathway.
Carcinoma, Ovarian Epithelial
Ubiquitin-conjugating enzyme 9 promotes epithelial ovarian cancer cell proliferation in vitro.
Carcinoma, Squamous Cell
Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product.
Carcinoma, Squamous Cell
Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas.
Carcinoma, Squamous Cell
Expression of UBE2Q2, a putative member of the ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia.
Carcinoma, Squamous Cell
Preclinical comparison of proteasome and ubiquitin E1 enzyme inhibitors in cutaneous squamous cell carcinoma: the identification of mechanisms of differential sensitivity.
Chikungunya Fever
ISG15 is critical in the control of Chikungunya virus infection independent of UbE1L mediated conjugation.
Colonic Neoplasms
Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH.
Colorectal Neoplasms
Bortezomib stabilizes mitotic cyclins and prevents cell cycle progression via inhibition of UBE2C in colorectal carcinoma.
Colorectal Neoplasms
Discovery of a First-In-Class Covalent Allosteric Inhibitor of SUMO E1 Activating Enzyme.
Colorectal Neoplasms
Promoter Methylation Status of Two Novel Human Genes, UBE2Q1 and UBE2Q2, in Colorectal Cancer: a New Finding in Iranian Patients.
Colorectal Neoplasms
Ubiquitin-conjugating enzyme E2T(UBE2T) promotes colorectal cancer progression by facilitating ubiquitination and degradation of p53.
Coronary Artery Disease
Rs46522 in the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with the Risk of Coronary Artery Disease in Individuals of Chinese Han Population with Type 2 Diabetes.
Cysts
The ubiquitin-activating enzyme (E1) of the early-branching eukaryote Giardia intestinalis shows unusual proteolytic modifications and play important roles during encystation.
Diabetes Mellitus
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Diabetes Mellitus
The Level of Autoantibodies Targeting Eukaryote Translation Elongation Factor 1 ?1 and Ubiquitin-Conjugating Enzyme 2L3 in Nondiabetic Young Adults.
Diabetes Mellitus, Type 1
The Level of Autoantibodies Targeting Eukaryote Translation Elongation Factor 1 ?1 and Ubiquitin-Conjugating Enzyme 2L3 in Nondiabetic Young Adults.
Diabetes Mellitus, Type 2
Rs46522 in the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with the Risk of Coronary Artery Disease in Individuals of Chinese Han Population with Type 2 Diabetes.
Diabetes Mellitus, Type 2
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
e1 ubiquitin-activating enzyme deficiency
Deficiency of a potential 3p21.3 tumor suppressor gene UBE1L (UBA7) does not accelerate lung cancer development in K-ras(LA2) mice.
e1 ubiquitin-activating enzyme deficiency
Hematopoietic cells from Ube1L-deficient mice exhibit an impaired proliferation defect under the stress of bone marrow transplantation.
Endometrial Neoplasms
UBE2C Is Upregulated by Estrogen and Promotes Epithelial-Mesenchymal Transition via p53 in Endometrial Cancer.
Esophageal Squamous Cell Carcinoma
Sensitization against anticancer drugs by transfection with UBE2I variant gene into ras-NIH3H3 mouse fibroblasts.
Fanconi Anemia
Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening.
Fanconi Anemia
Mind the metal: a fragment library-derived zinc impurity binds the E2 ubiquitin-conjugating enzyme Ube2T and induces structural rearrangements.
Foot-and-Mouth Disease
Comparative Proteomic Analysis of Wild-Type and SAP Domain Mutant Foot-and-Mouth Disease Virus-Infected Porcine Cells Identifies the Ubiquitin-Activating Enzyme UBE1 Required for Virus Replication.
Glioma
Forkhead Box M1 positively regulates UBE2C and protects glioma cells from autophagic death.
Glioma
Knockdown of ubiquitin-conjugating enzyme E2C/UbcH10 expression by RNA interference inhibits glioma cell proliferation and enhances cell apoptosis in vitro.
Head and Neck Neoplasms
Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer.
Hepatitis C
Hepatitis C Virus Downregulates Ubiquitin-Conjugating Enzyme E2S Expression To Prevent Proteasomal Degradation of NS5A, Leading to Host Cells More Sensitive to DNA Damage.
Herpes Simplex
Nucleotide sequence of a 55 kbp region from the right end of the genome of a pathogenic African swine fever virus isolate (Malawi LIL20/1).
Herpes Simplex
The degradation of promyelocytic leukemia and Sp100 proteins by herpes simplex virus 1 is mediated by the ubiquitin-conjugating enzyme UbcH5a.
Herpesviridae Infections
Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infection.
Huntington Disease
Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme.
Huntington Disease
Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases.
Hypersensitivity
Ubiquitin-mediated receptor degradation contributes to development of tolerance to MrgC agonist-induced pain inhibition in neuropathic rats.
Infections
Characterization of a ubiquitinated protein which is externally located in African swine fever virions.
Infections
Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus Regulators.
Infections
Ectopic expression of ubiquitin-conjugating enzyme gene from wild rice, OgUBC1, confers resistance against UV-B radiation and Botrytis infection in Arabidopsis thaliana.
Infections
Leishmania donovani targets tumor necrosis factor receptor-associated factor (TRAF) 3 for impairing TLR4-mediated host response.
Infections
Proteasome inhibition attenuates coxsackievirus-induced myocardial damage in mice.
Infections
Temporal SILAC-based quantitative proteomics identifies host factors involved in chikungunya virus replication.
Infections
The ubiquitin-proteasome system is required for African swine fever replication.
Infections
Treatment of Yersinia similis with the cationic lipid DOTAP enhances adhesion to and invasion into intestinal epithelial cells - A proof-of-principle study.
Influenza, Human
Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infection.
Insulin Resistance
Adipose-specific knockout of ubiquitin-conjugating enzyme E2L6 (Ube2l6) reduces diet-induced obesity, insulin resistance, and hepatic steatosis.
Insulin Resistance
Palmitate induces insulin resistance in human HepG2 hepatocytes by enhancing ubiquitination and proteasomal degradation of key insulin signaling molecules.
Intellectual Disability
A novel splice site mutation in the UBE2A gene leads to aberrant mRNA splicing in a Chinese patient with X-linked intellectual disability type Nascimento.
Leukemia
Case Report: The Formation of a Truncated PAX5 Transcript in a Case of Ph-Positive Mixed Phenotype Acute Leukemia With dic(7;9)(p11-p13;p13).
Leukemia
Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia.
Leukemia
The degradation of promyelocytic leukemia and Sp100 proteins by herpes simplex virus 1 is mediated by the ubiquitin-conjugating enzyme UbcH5a.
Leukemia
The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma.
Leukemia
UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Pharmacologic inhibition of the ubiquitin-activating enzyme induces ER stress and apoptosis in chronic lymphocytic leukemia and ibrutinib-resistant mantle cell lymphoma cells.
Leukemia, Myeloid
A low-density DNA microchip for the detection of (anti-)estrogenic compounds and their relative potencies.
Leukemia, Myeloid, Acute
Microarray-based analysis and clinical validation identify ubiquitin-conjugating enzyme E2E1 (UBE2E1) as a prognostic factor in acute myeloid leukemia.
Leukemia, Promyelocytic, Acute
Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia.
Leukemia, Promyelocytic, Acute
UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia.
Leukemia, T-Cell
The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation.
Lung Injury
PYR-41, A Ubiquitin-Activating Enzyme E1 Inhibitor, Attenuates Lung Injury in Sepsis.
Lung Neoplasms
A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme.
Lung Neoplasms
Deficiency of a potential 3p21.3 tumor suppressor gene UBE1L (UBA7) does not accelerate lung cancer development in K-ras(LA2) mice.
Lung Neoplasms
Down-regulation of epidermal growth factor receptor by curcumin-induced UBE1L in human bronchial epithelial cells.
Lung Neoplasms
Effects of ubiquitin-conjugating enzyme 2C on invasion, proliferation and cell cycling of lung cancer cells.
Lung Neoplasms
Immunohistochemical Analysis of Ubiquitin-Conjugating Enzyme in Lung Cancer: a Useful Tool for Diagnosis and Therapy.
Lung Neoplasms
Microarray analyses uncover UBE1L as a candidate target gene for lung cancer chemoprevention.
Lung Neoplasms
UBE2D1 RNA Expression Was an Independent Unfavorable Prognostic Indicator in Lung Adenocarcinoma, but Not in Lung Squamous Cell Carcinoma.
Lung Neoplasms
Ubiquitin-conjugating enzyme E2C regulates apoptosis-dependent tumor progression of non-small cell lung cancer via ERK pathway.
Lymphoma
Pharmacologic inhibition of the ubiquitin-activating enzyme induces ER stress and apoptosis in chronic lymphocytic leukemia and ibrutinib-resistant mantle cell lymphoma cells.
Lymphoma, B-Cell
Epstein-Barr virus-encoded microRNA BART15-3p promotes cell apoptosis partially by targeting BRUCE.
Lymphoma, B-Cell
Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A.
Lymphoma, B-Cell
Targeting ubiquitin-activating enzyme induces ER stress-mediated apoptosis in B-cell lymphoma cells.
Lymphoma, Large B-Cell, Diffuse
Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A.
Lymphoma, Large B-Cell, Diffuse
Targeting ubiquitin-activating enzyme induces ER stress-mediated apoptosis in B-cell lymphoma cells.
Lymphoma, Mantle-Cell
Pharmacologic inhibition of the ubiquitin-activating enzyme induces ER stress and apoptosis in chronic lymphocytic leukemia and ibrutinib-resistant mantle cell lymphoma cells.
Melanoma
Comprehensive Investigation into the Role of Ubiquitin-Conjugating Enzyme E2S in Melanoma Development.
Melanoma
SAGE and antibody array analysis of melanoma-infiltrated lymph nodes: identification of Ubc9 as an important molecule in advanced-stage melanomas.
Meningioma
RIZ1 negatively regulates ubiquitin-conjugating enzyme E2C/UbcH10 via targeting c-Myc in meningioma.
Mental Retardation, X-Linked
UBE2A, which encodes a ubiquitin-conjugating enzyme, is mutated in a novel X-linked mental retardation syndrome.
Multiple Myeloma
Blockade of ubiquitin-conjugating enzyme CDC34 enhances anti-myeloma activity of Bortezomib/Proteasome inhibitor PS-341.
Multiple Myeloma
Design, synthesis, and biological evaluation of novel ubiquitin-activating enzyme inhibitors.
Multiple Myeloma
Differential effect of MMSET mRNA levels on survival to first-line FOLFOX and second-line docetaxel in gastric cancer.
Multiple Myeloma
The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma.
Muscular Atrophy
Polyubiquitin in crustacean striated muscle: increased expression and conjugation during molt-induced claw muscle atrophy.
Muscular Atrophy, Spinal
Clinical and neuropathological features of X-linked spinal muscular atrophy (SMAX2) associated with a novel mutation in the UBA1 gene.
Muscular Atrophy, Spinal
UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy.
Myocardial Infarction
The rs46522 Polymorphism of the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with Abnormal Metabolic Parameters in Patients with Myocardial Infarction: The Genetics of Atherosclerosis Disease Mexican Study.
Nasopharyngeal Carcinoma
High expression of ubiquitin-conjugating enzyme 2C (UBE2C) correlates with nasopharyngeal carcinoma progression.
Neoplasm Metastasis
Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH.
Neoplasm Metastasis
Erratum to: Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-?B mediated matrix metalloproteinase-1 gene regulation.
Neoplasm Metastasis
Ubiquitin-conjugating enzyme complex Uev1A-Ubc13 promotes breast cancer metastasis through nuclear factor-[cyrillic small letter ka]B mediated matrix metalloproteinase-1 gene regulation.
Neoplasm Metastasis
Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade.
Neoplasms
A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment.
Neoplasms
A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles.
Neoplasms
Analysis of UbcH10 expression represents a useful tool for the diagnosis and therapy of astrocytic tumors.
Neoplasms
Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9.
Neoplasms
Bortezomib stabilizes mitotic cyclins and prevents cell cycle progression via inhibition of UBE2C in colorectal carcinoma.
Neoplasms
Cell division cycle 34 is highly expressed in hepatitis C virus-positive hepatocellular carcinoma with favorable phenotypes.
Neoplasms
Changes in the transcriptome of bovine ovarian cortex during follicle activation in vitro.
Neoplasms
Crystal structure of a human ubiquitin E1-ubiquitin complex reveals conserved functional elements essential for activity.
Neoplasms
Deficiency of a potential 3p21.3 tumor suppressor gene UBE1L (UBA7) does not accelerate lung cancer development in K-ras(LA2) mice.
Neoplasms
Degradation of NF-?B, p53 and other regulatory redox-sensitive proteins by thiol-conjugating and -nitrosylating drugs in human tumor cells.
Neoplasms
Depletion of UBE2C reduces ovarian cancer malignancy and reverses cisplatin resistance via downregulating CDK1.
Neoplasms
Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH.
Neoplasms
Downregulation of UBE2E2 in rat liver cells after hepatocarcinogen treatment facilitates cell proliferation and slowing down of DNA damage response in GST-P-expressing preneoplastic lesions.
Neoplasms
Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex.
Neoplasms
Exceptionally high UBE2C expression is a unique phenomenon in basal-like type breast cancer and is regulated by BRCA1.
Neoplasms
Exposure to cigarette smoke induces overexpression of von Hippel-Lindau tumor suppressor in mouse skeletal muscle.
Neoplasms
Expression of UBE2Q2, a putative member of the ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia.
Neoplasms
Forkhead Box M1 positively regulates UBE2C and protects glioma cells from autophagic death.
Neoplasms
Functional transcriptomic annotation and protein-protein interaction analysis identify EZH2 and UBE2C as key upregulated proteins in ovarian cancer.
Neoplasms
Genome-wide analysis of differentially expressed genes during the early stages of tomato infection by a potyvirus.
Neoplasms
High expression of UBE2C is associated with the aggressive progression and poor outcome of malignant glioma.
Neoplasms
High expression of ubiquitin-conjugating enzyme 2C (UBE2C) correlates with nasopharyngeal carcinoma progression.
Neoplasms
Identification of new SUMO activating enzyme 1 inhibitors using virtual screening and scaffold hopping.
Neoplasms
Identification of sumoylation activating enzyme 1 inhibitors by structure-based virtual screening.
Neoplasms
Inactivation of the human fragile histidine triad gene at 3p14.2 in monochromosomal human/mouse microcell hybrid-derived severe combined immunodeficient mouse tumors.
Neoplasms
Induction of proteasome expression in skeletal muscle is attenuated by inhibitors of NF-kappaB activation.
Neoplasms
Inhibiting Hdm2 and ubiquitin-activating enzyme: targeting the ubiquitin conjugating system in cancer.
Neoplasms
Inhibition of UBE2N-dependent CDK6 protein degradation by miR-934 promotes human bladder cancer cell growth.
Neoplasms
Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics.
Neoplasms
Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia.
Neoplasms
Involvement of ubiquitin-conjugating enzyme E2C in proliferation and invasion of prostate carcinoma cells.
Neoplasms
Knockdown of UbcH10 Enhances the Chemosensitivity of Dual Drug Resistant Breast Cancer Cells to Epirubicin and Docetaxel.
Neoplasms
Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization.
Neoplasms
Mechanism of attenuation of skeletal muscle protein catabolism in cancer cachexia by eicosapentaenoic acid.
Neoplasms
Mechanism of dose-dependent regulation of UBE1L by polyphenols in human bronchial epithelial cells.
Neoplasms
Microarray analyses uncover UBE1L as a candidate target gene for lung cancer chemoprevention.
Neoplasms
miR-146b antagomir-treated human Tregs acquire increased GVHD inhibitory potency.
Neoplasms
Modification of gene expression by melatonin in UVB-irradiated HaCaT keratinocyte cell lines using a cDNA microarray.
Neoplasms
Mycobacterium tuberculosis protein kinase G acts as an unusual ubiquitinating enzyme to impair host immunity.
Neoplasms
New Insights into the Role of E2s in the Pathogenesis of Diseases: Lessons Learned from UBE2O.
Neoplasms
Nitric oxide prodrug JS-K inhibits ubiquitin E1 and kills tumor cells retaining wild-type p53.
Neoplasms
Oncogenic Activities Of UBE2S Mediated By VHL/HIF-1?/STAT3 Signal Via The Ubiquitin-Proteasome System In PDAC.
Neoplasms
Overexpression of UBE2C correlates with poor prognosis in gastric cancer patients.
Neoplasms
Protein cross-linking as a novel mechanism of action of a ubiquitin-activating enzyme inhibitor with anti-tumor activity.
Neoplasms
RAD6 promotes DNA repair and stem cell signaling in ovarian cancer and is a promising therapeutic target to prevent and treat acquired chemoresistance.
Neoplasms
Reference gene selection for quantitative real-time reverse-transcriptase PCR in orchardgrass subjected to various abiotic stresses.
Neoplasms
S-adenosylmethionine regulates ubiquitin-conjugating enzyme 9 protein expression and sumoylation in murine liver and human cancers.
Neoplasms
SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-243.
Neoplasms
Targeting the ubiquitin-conjugating enzyme E2D4 for cancer drug discovery-a structure-based approach.
Neoplasms
The AP-1/NF-kappaB double inhibitor SP100030 can revert muscle wasting during experimental cancer cachexia.
Neoplasms
The clinicopathological significance of UBE2C in breast cancer: a study based on immunohistochemistry, microarray and RNA-sequencing data.
Neoplasms
The clinicopathological significance of ubiquitin-conjugating enzyme E2C, leucine-rich repeated-containing G protein-coupled receptor, WW domain-containing oxidoreductase, and vasculogenic mimicry in invasive breast carcinoma.
Neoplasms
The expression of ubiquitin-conjugating enzyme E2C and KAI1 in ovarian carcinoma and their clinical significance.
Neoplasms
The Function of SUMOylation and Its Role in the Development of Cancer Cells under Stress Conditions: A Systematic Review.
Neoplasms
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation.
Neoplasms
The ubiquitin-conjugating enzyme E2-EPF is overexpressed in cervical cancer and associates with tumor growth.
Neoplasms
The ubiquitin-conjugating enzyme E2-EPF is overexpressed in primary breast cancer and modulates sensitivity to topoisomerase II inhibition.
Neoplasms
Transcript Levels of Androgen Receptor Variant 7 and Ubiquitin-Conjugating Enzyme 2C in Hormone Sensitive Prostate Cancer and Castration-Resistant Prostate Cancer.
Neoplasms
UBE2C functions as a potential oncogene by enhancing cell proliferation, migration, invasion, and drug resistance in hepatocellular carcinoma cells.
Neoplasms
UBE2C is a marker of unfavorable prognosis in bladder cancer after radical cystectomy.
Neoplasms
UBE2C is a Potential Biomarker for Tumorigenesis and Prognosis in Tongue Squamous Cell Carcinoma.
Neoplasms
UBE2C is overexpressed in ESCC tissues and its abrogation attenuates the malignant phenotype of ESCC cell lines.
Neoplasms
UBE2C Is Upregulated by Estrogen and Promotes Epithelial-Mesenchymal Transition via p53 in Endometrial Cancer.
Neoplasms
UBE2I promotes metastasis and correlates with poor prognosis in hepatocellular carcinoma.
Neoplasms
UBE2M promotes cell proliferation via the ?-catenin/cyclin D1 signaling in hepatocellular carcinoma.
Neoplasms
UBE2O Promotes Progression and Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma.
Neoplasms
UBE2S associated with OSCC proliferation by promotion of P21 degradation via the ubiquitin-proteasome system.
Neoplasms
UBE2S enhances the ubiquitination of p53 and exerts oncogenic activities in hepatocellular carcinoma.
Neoplasms
UBE2S exerts oncogenic activities in urinary bladder cancer by ubiquitinating TSC1.
Neoplasms
UBE2S mediates tumor progression via SOX6/?-Catenin signaling in endometrial cancer.
Neoplasms
UBE2S promotes the progression and Olaparib resistance of ovarian cancer through Wnt/?-catenin signaling pathway.
Neoplasms
UBE2S promotes the proliferation and survival of human lung adenocarcinoma cells.
Neoplasms
Ubiquitin-conjugating enzyme E2C regulates apoptosis-dependent tumor progression of non-small cell lung cancer via ERK pathway.
Neoplasms
Ubiquitin-conjugating enzyme UbcH10 promotes gastric cancer growth and is a potential biomarker for gastric cancer.
Neoplasms
Up-regulation of interferon-stimulated gene 15 and its conjugation machinery, UbE1L and UbcH8 expression by tumor necrosis factor-? through p38 MAPK and JNK signaling pathways in human lung carcinoma.
Neoplasms
Up-regulation of miR-455-5p by the TGF-?-SMAD signalling axis promotes the proliferation of oral squamous cancer cells by targeting UBE2B.
Neoplasms
Uraemic serum induces dysfunction of vascular endothelial cells: role of ubiquitin-proteasome pathway.
Neurodegenerative Diseases
Expression profiling of the ubiquitin conjugating enzyme UbcM2 in murine brain reveals modest age-dependent decreases in specific neurons.
Neurodegenerative Diseases
The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.
Obesity
Adipose-specific knockout of ubiquitin-conjugating enzyme E2L6 (Ube2l6) reduces diet-induced obesity, insulin resistance, and hepatic steatosis.
Obesity, Morbid
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Papilloma
Promoter analysis of the human ubiquitin-conjugating enzyme gene family UBE2L1-4, including UBE2L3 which encodes UbcH7.
Parkinson Disease
Ubiquitin enzymes, ubiquitin and proteasome activity in blood mononuclear cells of MCI, Alzheimer and Parkinson patients.
Pheochromocytoma
The N-end rule ubiquitin-conjugating enzyme, HR6B, is up-regulated by nerve growth factor and required for neurite outgrowth.
Pituitary Neoplasms
Identification of the potential therapeutic target gene UBE2C in human hepatocellular carcinoma: An investigation based on GEO and TCGA databases.
Pituitary Neoplasms
Modified cell cycle status in a mouse model of altered neuronal vulnerability (slow Wallerian degeneration; Wlds).
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Expression and localization of the CDC34 ubiquitin-conjugating enzyme in pediatric acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Expression of UBE2Q2, a putative member of the ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia.
Prostatic Neoplasms
Identification of UBE2C as hub gene in driving prostate cancer by integrated bioinformatics analysis.
Prostatic Neoplasms
The Positive Correlations between the Expression of Histopathological Ubiquitin-Conjugating Enzyme 2O Staining and Prostate Cancer Advancement.
Prostatic Neoplasms
Transcript Levels of Androgen Receptor Variant 7 and Ubiquitin-Conjugating Enzyme 2C in Hormone Sensitive Prostate Cancer and Castration-Resistant Prostate Cancer.
Retinoblastoma
ARI-1, an RBR family ubiquitin-ligase, functions with UBC-18 to regulate pharyngeal development in C. elegans.
RNA Virus Infections
Ubiquitin-conjugating enzyme UBE2J1 negatively modulates interferon pathway and promotes RNA virus infection.
Sepsis
PYR-41, A Ubiquitin-Activating Enzyme E1 Inhibitor, Attenuates Lung Injury in Sepsis.
Skin Abnormalities
A novel splice site mutation in the UBE2A gene leads to aberrant mRNA splicing in a Chinese patient with X-linked intellectual disability type Nascimento.
Spinocerebellar Ataxias
The ubiquitin-conjugating enzyme UbcH6 regulates the transcriptional repression activity of the SCA1 gene product ataxin-1.
Squamous Cell Carcinoma of Head and Neck
Expression of UBE2Q2, a putative member of the ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia.
Squamous Cell Carcinoma of Head and Neck
UBE2S associated with OSCC proliferation by promotion of P21 degradation via the ubiquitin-proteasome system.
Starvation
Downregulation of ubiquitin-dependent proteolysis by eicosapentaenoic acid in acute starvation.
Stomach Neoplasms
Ubiquitin-conjugating enzyme UbcH10 promotes gastric cancer growth and is a potential biomarker for gastric cancer.
Tuberous Sclerosis
The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.
Uterine Cervical Neoplasms
Dominant negative Ubiquitin-conjugating enzyme E2C sensitizes cervical cancer cells to radiation.
Uterine Cervical Neoplasms
The ubiquitin-conjugating enzyme E2-EPF is overexpressed in cervical cancer and associates with tumor growth.
Virus Diseases
ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus.
Virus Diseases
Mechanism of dose-dependent regulation of UBE1L by polyphenols in human bronchial epithelial cells.
Virus Diseases
Transmembrane Protein pUL50 of Human Cytomegalovirus Inhibits ISGylation by Downregulating UBE1L.
Vitiligo
Autoantigens in Vitiligo Identified by the Serological Selection of a Phage-Displayed Melanocyte cDNA Expression Library.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). UBA2_YEAST
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
636
0
71259
Swiss-Prot
Secretory Pathway (Reliability: 2)
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystal structures of the C-terminal ubiquitin fold domain from yeast Uba2 alone and in complex with E2 enzyme Ubc9. Uba2 undergoes remarkable conformational changes during the reaction. The structure of the Uba2 domain-Ubc9 complex reveals interactions unique to Sumo E1 and E2. Comparison with a previous Ubc9-E3 complex structure demonstrates overlap between Uba2 and E3 binding sites on Ubc9, indicating that loading with Sumo and E3-catalyzed transfer to substrates are strictly separate steps
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wang, J.; Taherbhoy, A.M.; Hunt, H.W.; Seyedin, S.N.; Miller, D.W., Miller, D.J.; Huang, D.T.; Schulman, B.A.
Crystal structure of UBA2ufd-Ubc9: Insights into E1-E2 interactions in Sumo pathways
PLoS ONE
1
e15805
2010
Saccharomyces cerevisiae (P52488), Saccharomyces cerevisiae
brenda
EXTERNAL LINKS (specific for EC-Number 6.2.1.45)
Transporter Classification Database (TCDB): 3.A.25.2.1
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
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