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Information on EC 6.2.1.44 - 3-(methylthio)propionyl-CoA ligase
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6.2.1.44 3-(methylthio)propionyl-CoA ligaseIUBMB Comments
The enzyme is part of a dimethylsulfoniopropanoate demethylation pathway in the marine bacteria Ruegeria pomeroyi and Pelagibacter ubique. It also occurs in some nonmarine bacteria capable of metabolizing dimethylsulfoniopropionate (e.g. Burkholderia thailandensis, Pseudomonas aeruginosa, and Silicibacter lacuscaerulensis). It requires Mg2+ .
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Word Map
- 6.2.1.44
- methylglyoxal
-
glycation
-
dicarbonyls
- s-d-lactoylglutathione
- monodehydroascorbate
- mdhar
-
d-lactic
- d-lactate
- dehydroascorbate
-
alpha-oxoaldehydes
-
mg-induced
-
hemithioacetal
-
4.4.1.5
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
3-methylmercaptopropionyl-CoA ligase, BTH_DmdB2, BTH_I2141, DmdB, methylmercaptopropionate-coenzyme A ligase, MMPA-CoA ligase, PA4198, PA_DmdB1, PU_DmdB1, RL_DmdB1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
3-methylmercaptopropionyl-CoA ligase
-
-
-
-
BTH_DmdB2
BTH_I2141
DmdB
methylmercaptopropionate-coenzyme A ligase
MMPA-CoA ligase
PA4198
PA_DmdB1
PU_DmdB1
RL_DmdB1
RL_DmdB2
RPO_DmdB1
two forms of DmdB are present in the marine roseobacter Ruegeria pomeroyi DSS-3, RPO_DmdB1 and RPO_DmdB2
RPO_DmdB2
two forms of DmdB are present in the marine roseobacter Ruegeria pomeroyi DSS-3, RPO_DmdB1 and RPO_DmdB2
SAR11_0248
SL1157_1815
SL1157_2728
DmdB
two forms of DmdB are present in the marine roseobacter Ruegeria pomeroyi DSS-3, RPO_DmdB1 and RPO_DmdB2
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + 3-(methylsulfanyl)propanoate + CoA = AMP + diphosphate + 3-(methylsulfanyl)propanoyl-CoA
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
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SYSTEMATIC NAME
IUBMB Comments
3-(methylthio)propanoate:CoA ligase (AMP-forming)
The enzyme is part of a dimethylsulfoniopropanoate demethylation pathway in the marine bacteria Ruegeria pomeroyi and Pelagibacter ubique. It also occurs in some nonmarine bacteria capable of metabolizing dimethylsulfoniopropionate (e.g. Burkholderia thailandensis, Pseudomonas aeruginosa, and Silicibacter lacuscaerulensis). It requires Mg2+ [2].
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 3-(methylthio)propanoate + CoA
AMP + diphosphate + 3-methylmercaptopropionyl-CoA
once released from phytoplankton, marine bacteria degrade dimethylsulfoniopropionate by either the cleavage pathway to form the volatile gas dimethylsulfide or the demethylation pathway, yielding methanethiol, which is readily assimilated or oxidized. The enzyme DmdB, a methylmercaptopropionate-coenzyme A ligase, catalyzes the second step in the demethylation pathway and is a major regulatory point. Two forms of DmdB are present in the marine roseobacter Ruegeria pomeroyi DSS-3, RPO_DmdB1 and RPO_DmdB2
-
-
?
ATP + 3-(methylthio)propanoate + CoA
AMP + diphosphate + 3-(methylthio)propionyl-CoA
-
-
-
?
ATP + 3-(methylthio)propanoate + CoA
AMP + diphosphate + 3-(methylthio)propionyl-CoA
-
-
-
?
ATP + 3-(methylthio)propanoate + CoA
AMP + diphosphate + 3-(methylthio)propionyl-CoA
once released from phytoplankton, marine bacteria degrade dimethylsulfoniopropionate by either the cleavage pathway to form the volatile gas dimethylsulfide or the demethylation pathway, yielding methanethiol, which is readily assimilated or oxidized. The enzyme DmdB, a methylmercaptopropionate-coenzyme A ligase, catalyzes the second step in the demethylation pathway and is a major regulatory point. Two forms of DmdB are present in the marine roseobacter Ruegeria pomeroyi DSS-3, RPO_DmdB1 and RPO_DmdB2
-
-
?
ATP + 3-(methylthio)propanoate + CoA
AMP + diphosphate + 3-(methylthio)propionyl-CoA
-
-
-
?
ATP + 3-(methylthio)propanoate + CoA
AMP + diphosphate + 3-(methylthio)propionyl-CoA
-
-
-
?
ATP + 3-(methylthio)propanoate + CoA
AMP + diphosphate + 3-(methylthio)propionyl-CoA
-
-
-
?
ATP + 3-(methylthio)propanoate + CoA
AMP + diphosphate + 3-(methylthio)propionyl-CoA
-
-
-
?
ATP + 3-(methylthio)propanoate + CoA
AMP + diphosphate + 3-(methylthio)propionyl-CoA
degradation 3-(methylthio)propanoate, the first product in 3-(dimethylsulfonio)propanoate degradation. 3-(Dimethylsulfonio)propanoate is an osmolyte of many marine algae and certain plants. The global importance of dimethylsulfoniopropionate lies in its availability as a carbon and sulfur source for marine microorganisms and as a precursor of the gas dimethylsulfide, the oceanic emission of which leads to the formation of cloud condensation nuclei and promotion of solar radiation backscatter. Two competing pathways exist for the bacterial catabolism of 3-(dimethylsulfonio)propanoate, one releasing dimethylsulphide and the other releasing methanethiol
-
-
?
ATP + 3-(methylthio)propanoate + CoA
AMP + diphosphate + 3-(methylthio)propionyl-CoA
once released from phytoplankton, marine bacteria degrade dimethylsulfoniopropionate by either the cleavage pathway to form the volatile gas dimethylsulfide or the demethylation pathway, yielding methanethiol, which is readily assimilated or oxidized. The enzyme DmdB, a methylmercaptopropionate-coenzyme A ligase, catalyzes the second step in the demethylation pathway and is a major regulatory point. Two forms of DmdB are present in the marine roseobacter Ruegeria pomeroyi DSS-3, RPO_DmdB1 and RPO_DmdB2
-
-
?
ATP + 3-methylbutanoate + CoA
AMP + diphosphate + 3-methylbutanoyl-CoA
activity is 4% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + 3-methylbutanoate + CoA
AMP + diphosphate + 3-methylbutanoyl-CoA
activity is 8% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + 3-methylbutanoate + CoA
AMP + diphosphate + 3-methylbutanoyl-CoA
activity is 18% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + 3-methylbutanoate + CoA
AMP + diphosphate + 3-methylbutanoyl-CoA
activity is 15% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + 3-methylbutanoate + CoA
AMP + diphosphate + 3-methylbutanoyl-CoA
activity is 5% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + 3-methylbutanoate + CoA
AMP + diphosphate + 3-methylbutanoyl-CoA
activity is 14% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + 3-methylbutanoate + CoA
AMP + diphosphate + 3-methylbutanoyl-CoA
activity is 19% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
activity is 10% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
activity is 10% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
activity is 110% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
activity is 110% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
activity is 151% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
activity is 151% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + acetate + CoA
AMP + diphosphate + acetyl-CoA
activity is 10% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + acrylate + CoA
AMP + diphosphate + acryloyl-CoA
activity is 15% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + acrylate + CoA
AMP + diphosphate + acryloyl-CoA
activity is 15% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + acrylate + CoA
AMP + diphosphate + acryloyl-CoA
activity is 50% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + acrylate + CoA
AMP + diphosphate + acryloyl-CoA
activity is 50% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + acrylate + CoA
AMP + diphosphate + acryloyl-CoA
activity is 65% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + acrylate + CoA
AMP + diphosphate + acryloyl-CoA
activity is 65% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + acrylate + CoA
AMP + diphosphate + acryloyl-CoA
activity is 29% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + acrylate + CoA
AMP + diphosphate + acryloyl-CoA
activity is 6% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + acrylate + CoA
AMP + diphosphate + acryloyl-CoA
activity is 29% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + acrylate + CoA
AMP + diphosphate + acryloyl-CoA
activity is 6% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + acrylate + CoA
AMP + diphosphate + acryloyl-CoA
activity is 56% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + acrylate + CoA
AMP + diphosphate + acryloyl-CoA
activity is 78% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + butyrate + CoA
AMP + diphosphate + butyryl-CoA
activity is 93% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + butyrate + CoA
AMP + diphosphate + butyryl-CoA
activity is 93% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + butyrate + CoA
AMP + diphosphate + butyryl-CoA
activity is 160% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + butyrate + CoA
AMP + diphosphate + butyryl-CoA
activity is 160% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + butyrate + CoA
AMP + diphosphate + butyryl-CoA
activity is 121% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + butyrate + CoA
AMP + diphosphate + butyryl-CoA
activity is 121% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + butyrate + CoA
AMP + diphosphate + butyryl-CoA
activity is 113% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + butyrate + CoA
AMP + diphosphate + butyryl-CoA
activity is 81% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + butyrate + CoA
AMP + diphosphate + butyryl-CoA
activity is 113% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + butyrate + CoA
AMP + diphosphate + butyryl-CoA
activity is 81% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + butyrate + CoA
AMP + diphosphate + butyryl-CoA
activity is 36% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + butyrate + CoA
AMP + diphosphate + butyryl-CoA
activity is 73% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + crotonate + CoA
AMP + diphosphate + crotonyl-CoA
activity is 87% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + crotonate + CoA
AMP + diphosphate + crotonyl-CoA
activity is 2% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + crotonate + CoA
AMP + diphosphate + crotonyl-CoA
activity is 63% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + crotonate + CoA
AMP + diphosphate + crotonyl-CoA
activity is 32% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + crotonate + CoA
AMP + diphosphate + crotonyl-CoA
activity is 41% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + crotonate + CoA
AMP + diphosphate + crotonyl-CoA
activity is 109% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + crotonate + CoA
AMP + diphosphate + crotonyl-CoA
activity is 63% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + hexanoate + CoA
AMP + diphosphate + hexanoyl-CoA
activity is 94% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + hexanoate + CoA
AMP + diphosphate + hexanoyl-CoA
activity is 5% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + hexanoate + CoA
AMP + diphosphate + hexanoyl-CoA
activity is 12% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + hexanoate + CoA
AMP + diphosphate + hexanoyl-CoA
activity is 17% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + hexanoate + CoA
AMP + diphosphate + hexanoyl-CoA
activity is 62% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + hexanoate + CoA
AMP + diphosphate + hexanoyl-CoA
activity is 17% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + hexanoate + CoA
AMP + diphosphate + hexanoyl-CoA
activity is 27% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + isobutyrate + CoA
AMP + diphosphate + isobutyryl-CoA
activity is 5% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + isobutyrate + CoA
AMP + diphosphate + isobutyryl-CoA
activity is 13% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + isobutyrate + CoA
AMP + diphosphate + isobutyryl-CoA
activity is 48% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + isobutyrate + CoA
AMP + diphosphate + isobutyryl-CoA
activity is 10% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + isobutyrate + CoA
AMP + diphosphate + isobutyryl-CoA
activity is 7% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + isobutyrate + CoA
AMP + diphosphate + isobutyryl-CoA
activity is 12% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + isobutyrate + CoA
AMP + diphosphate + isobutyryl-CoA
activity is 30% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + methylbutyrate + CoA
AMP + diphosphate + methylbutyryl-CoA
activity is 23% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + methylbutyrate + CoA
AMP + diphosphate + methylbutyryl-CoA
activity is 8% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + methylbutyrate + CoA
AMP + diphosphate + methylbutyryl-CoA
activity is 24% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + methylbutyrate + CoA
AMP + diphosphate + methylbutyryl-CoA
activity is 18% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + methylbutyrate + CoA
AMP + diphosphate + methylbutyryl-CoA
activity is 20% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + methylbutyrate + CoA
AMP + diphosphate + methylbutyryl-CoA
activity is 10% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + methylbutyrate + CoA
AMP + diphosphate + methylbutyryl-CoA
activity is 39% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + pentanoate + CoA
AMP + diphosphate + pentanoyl-CoA
activity is 68% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + pentanoate + CoA
AMP + diphosphate + pentanoyl-CoA
activity is 68% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + pentanoate + CoA
AMP + diphosphate + pentanoyl-CoA
activity is 18% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + pentanoate + CoA
AMP + diphosphate + pentanoyl-CoA
activity is 91% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + pentanoate + CoA
AMP + diphosphate + pentanoyl-CoA
activity is 179% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + pentanoate + CoA
AMP + diphosphate + pentanoyl-CoA
activity is 49% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + pentanoate + CoA
AMP + diphosphate + pentanoyl-CoA
activity is 179% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + pentanoate + CoA
AMP + diphosphate + pentanoyl-CoA
activity is 31% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + pentanoate + CoA
AMP + diphosphate + pentanoyl-CoA
activity is 51% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + propionate + CoA
AMP + diphosphate + propionyl-CoA
activity is 45% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + propionate + CoA
AMP + diphosphate + propionyl-CoA
activity is 45% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + propionate + CoA
AMP + diphosphate + propionyl-CoA
activity is 13% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + propionate + CoA
AMP + diphosphate + propionyl-CoA
activity is 13% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + propionate + CoA
AMP + diphosphate + propionyl-CoA
activity is 124% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + propionate + CoA
AMP + diphosphate + propionyl-CoA
activity is 124% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + propionate + CoA
AMP + diphosphate + propionyl-CoA
activity is 126% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + propionate + CoA
AMP + diphosphate + propionyl-CoA
activity is 72% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + propionate + CoA
AMP + diphosphate + propionyl-CoA
activity is 72% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + propionate + CoA
AMP + diphosphate + propionyl-CoA
activity is 126% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + propionate + CoA
AMP + diphosphate + propionyl-CoA
activity is 16% of the activity with 3-(methylthio)propanoate
-
-
?
ATP + propionate + CoA
AMP + diphosphate + propionyl-CoA
activity is 77% of the activity with 3-(methylthio)propanoate
-
-
?
additional information
?
-
no activity with acetate, caprylate and caprate
-
-
?
additional information
?
-
-
no activity with acetate, caprylate and caprate
-
-
?
additional information
?
-
no activity with acetate, caprylate and caprate
-
-
?
additional information
?
-
no activity with caprylate and caprate
-
-
?
additional information
?
-
-
no activity with caprylate and caprate
-
-
?
additional information
?
-
no activity with caprylate and caprate
-
-
?
additional information
?
-
no activity with caprylate and caprate
-
-
?
additional information
?
-
no activity with caprylate and caprate
-
-
?
additional information
?
-
no activity with acetate, caprylate and caprate
-
-
?
additional information
?
-
no activity with acetate, caprylate and caprate
-
-
?
additional information
?
-
-
no activity with acetate, caprylate and caprate
-
-
?
additional information
?
-
no activity with caprylate and caprate
-
-
?
additional information
?
-
no activity with caprylate and caprate
-
-
?
additional information
?
-
-
no activity with caprylate and caprate
-
-
?
additional information
?
-
no activity with acetate, caprylate and caprate
-
-
?
additional information
?
-
no activity with acetate, caprylate and caprate
-
-
?
additional information
?
-
-
no activity with acetate, caprylate and caprate
-
-
?
additional information
?
-
no activity with caprylate and caprate
-
-
?
additional information
?
-
no activity with caprylate and caprate
-
-
?
additional information
?
-
-
no activity with caprylate and caprate
-
-
?
additional information
?
-
no activity with acetate, caprylate and caprate
-
-
?
additional information
?
-
no activity with acetate, caprylate and caprate
-
-
?
additional information
?
-
no activity with caprylate and caprate
-
-
?
additional information
?
-
no activity with caprylate and caprate
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 3-(methylthio)propanoate + CoA
AMP + diphosphate + 3-methylmercaptopropionyl-CoA
once released from phytoplankton, marine bacteria degrade dimethylsulfoniopropionate by either the cleavage pathway to form the volatile gas dimethylsulfide or the demethylation pathway, yielding methanethiol, which is readily assimilated or oxidized. The enzyme DmdB, a methylmercaptopropionate-coenzyme A ligase, catalyzes the second step in the demethylation pathway and is a major regulatory point. Two forms of DmdB are present in the marine roseobacter Ruegeria pomeroyi DSS-3, RPO_DmdB1 and RPO_DmdB2
-
-
?
ATP + 3-(methylthio)propanoate + CoA
AMP + diphosphate + 3-(methylthio)propionyl-CoA
once released from phytoplankton, marine bacteria degrade dimethylsulfoniopropionate by either the cleavage pathway to form the volatile gas dimethylsulfide or the demethylation pathway, yielding methanethiol, which is readily assimilated or oxidized. The enzyme DmdB, a methylmercaptopropionate-coenzyme A ligase, catalyzes the second step in the demethylation pathway and is a major regulatory point. Two forms of DmdB are present in the marine roseobacter Ruegeria pomeroyi DSS-3, RPO_DmdB1 and RPO_DmdB2
-
-
?
ATP + 3-(methylthio)propanoate + CoA
AMP + diphosphate + 3-(methylthio)propionyl-CoA
degradation 3-(methylthio)propanoate, the first product in 3-(dimethylsulfonio)propanoate degradation. 3-(Dimethylsulfonio)propanoate is an osmolyte of many marine algae and certain plants. The global importance of dimethylsulfoniopropionate lies in its availability as a carbon and sulfur source for marine microorganisms and as a precursor of the gas dimethylsulfide, the oceanic emission of which leads to the formation of cloud condensation nuclei and promotion of solar radiation backscatter. Two competing pathways exist for the bacterial catabolism of 3-(dimethylsulfonio)propanoate, one releasing dimethylsulphide and the other releasing methanethiol
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ATP + 3-(methylthio)propanoate + CoA
AMP + diphosphate + 3-(methylthio)propionyl-CoA
once released from phytoplankton, marine bacteria degrade dimethylsulfoniopropionate by either the cleavage pathway to form the volatile gas dimethylsulfide or the demethylation pathway, yielding methanethiol, which is readily assimilated or oxidized. The enzyme DmdB, a methylmercaptopropionate-coenzyme A ligase, catalyzes the second step in the demethylation pathway and is a major regulatory point. Two forms of DmdB are present in the marine roseobacter Ruegeria pomeroyi DSS-3, RPO_DmdB1 and RPO_DmdB2
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
K2SO4
LiCl
Mg2+
NH4Cl
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
dimethylsulfoniopropionate
inhibited by physiological concentrations (70 mM). ADP reverses the inhibition of RPO_DmdB1, suggesting that this enzyme was responsive to cellular energy charge; inhibited by physiological concentrations (70 mM). ADP reverses the inhibition of RPO_DmdB1, suggesting that this enzyme was responsive to cellular energy charge. 3-(Methylthio)propanoate reverses the inhibition of RPO_DmdB2, suggesting that a complex regulatory system exists
(NH4)2SO4
0.4 M, 29% inhibition; 0.4 M, 43% inhibition