Information on EC 6.2.1.40 - 4-hydroxybutyrate-CoA ligase (AMP-forming)

for references in articles please use BRENDA:EC6.2.1.40
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EC Tree
     6 Ligases
         6.2 Forming carbon-sulfur bonds
             6.2.1 Acid-thiol ligases
                6.2.1.40 4-hydroxybutyrate-CoA ligase (AMP-forming)
IUBMB Comments
Isolated from the archaeon Metallosphaera sedula. Involved in the 3-hydroxypropanoate/4-hydroxybutanoate cycle. cf. EC 6.2.1.56, 4-hydroxybutyrate---CoA ligase (ADP-forming).
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
4-hydroxybutyrate-CoA ligase (AMP forming), 4-hydroxybutyrate-CoA synthetase, Msed_0394, Msed_0406, Msed_1353, Tneu_0420, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + 4-hydroxybutanoate + CoA = AMP + diphosphate + 4-hydroxybutanoyl-CoA
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