Information on EC 6.2.1.18 - citrate-CoA ligase

for references in articles please use BRENDA:EC6.2.1.18
Word Map on EC 6.2.1.18
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

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EC NUMBER
COMMENTARY hide
6.2.1.18
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RECOMMENDED NAME
GeneOntology No.
citrate-CoA ligase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + citrate + CoA = ADP + phosphate + (3S)-citryl-CoA
show the reaction diagram
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acid-thiol ligation
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
reductive TCA cycle II
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Carbon fixation pathways in prokaryotes
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Metabolic pathways
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Microbial metabolism in diverse environments
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SYSTEMATIC NAME
IUBMB Comments
citrate:CoA ligase (ADP-forming)
The enzyme is a component of EC 2.3.3.8 ATP citrate synthase.
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CAS REGISTRY NUMBER
COMMENTARY hide
856428-87-0
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
phylogenetic analysis of the distribution of the alternative CO2 fixation pathway catalyzed by two separate enzymes, citryl-CoA synthetase and citryl-CoA lyase in Aquificaceae populations, phylogenetic analysis, overview; phylogenetic analysis of the distribution of the alternative CO2 fixation pathway catalyzed by two separate enzymes, citryl-CoA synthetase and citryl-CoA lyase in Aquificaceae populations, phylogenetic analysis, overview
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + citrate + CoA
ADP + phosphate + (3S)-citryl-CoA
show the reaction diagram
ATP + citrate + CoA
ADP + phosphate + citryl-CoA
show the reaction diagram
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + citrate + CoA
ADP + phosphate + (3S)-citryl-CoA
show the reaction diagram
Q75VW6, Q75VW8
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?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.071
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in 100 mM HEPES/NaOH, pH 8.3, 5 mM dithioerythritol, 5 mM MgCl2, 3 mM ATP, 0.5 mM CoA, 0.4 mM NADH, and 3 mM D-citrate
0.082
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in 100 mM HEPES/NaOH, pH 8.3, 5 mM dithioerythritol, 5 mM MgCl2, 3 mM ATP, 0.5 mM CoA, 0.4 mM NADH, and 3 mM D-citrate
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
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the enzyme is a component of EC 4.1.3.8
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
gene ccsA, DNA and amino acid sequence analysis and phylogenetic analysis; gene ccsA, DNA and amino acid sequence analysis and phylogenetic analysis
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LINKS TO OTHER DATABASES (specific for EC-Number 6.2.1.18)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)