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The expected taxonomic range for this enzyme is: Rattus norvegicus
Synonyms gtp-dependent acyl-coa synthetase, more
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Acid-CoA ligase (GDP)
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Acid:CoA ligase (GDP)
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Acyl coenzyme A synthetase (GDP-forming)
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Acyl-CoA synthetase (GDP-forming)
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GTP-dependent acyl-CoA synthetase
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Synthetase, acyl coenzyme A (guanosine diphosphate-forming)
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GTP + octanoate + CoA = GDP + phosphate + octanoyl-CoA
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Acid-thiol ligation
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carboxylic acid:CoA ligase (GDP-forming)
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GTP + butyrate + CoA
GDP + phosphate + butyryl-CoA
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Substrates: - Products: -
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GTP + octanoate + CoA
GDP + phosphate + octanoyl-CoA
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GTP + oleate + CoA
GDP + phosphate + oleoyl-CoA
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GTP + palmitate + CoA
GDP + phosphate + palmitoyl-CoA
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additional information
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additional information
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Substrates: the different specificity of the isolated GTP-dependent enzymes for fatty acid substrates results from their different lecithin contents Products: -
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additional information
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Substrates: enzyme does not play an important role in the activation of fatty acids by uncoupled mitochondria Products: -
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additional information
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Substrates: enzyme does not play an important role in the activation of fatty acids by uncoupled mitochondria Products: -
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4'-phosphopantetheine
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contains 1 M 4´-phosphopantetheine per 20000 g enzyme
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F-
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2 mM, complete inhibition
phosphate
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5 mM, 70% inhibition
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brenda
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brenda
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the enzyme shows a small slow rise after birth, followed by an overall decline to adult values
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exclusively associated with the inner membrane-matrix
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Highest Expressing Human Cell Lines
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Londesborough, J.C.; Webster, L.T.
Fatty acyl-CoA synthetases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
10
469-488
1974
Rattus norvegicus
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Foster, P.C.; Bailey, E.
Changes in the activities of the enzymes of hepatic fatty acid oxidation during development of the rat
Biochem. J.
154
49-56
1976
Rattus norvegicus
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Foster, P.C.; Bailey, E.
Changes in hepatic fatty acid degradation during development of the laboratory rat
Biochem. Soc. Trans.
2
1279-1281
1974
Rattus norvegicus
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brenda
Batenburg, J.J.; Van den Bergh, S.G.
The mechanism of inhibition by fluoride of fatty acid oxidation in uncoupled mitochondria
Biochim. Biophys. Acta
316
136-142
1973
Rattus norvegicus
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Lippel, K.; Beattie, D.S.
The submitochondrial distribution of acid:CoA ligase (AMP) and acid:CoA ligase (GDP) in rat liver mitochondria
Biochim. Biophys. Acta
218
227-232
1970
Rattus norvegicus
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brenda
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