Reference on EC 6.1.2.1 - D-alanine-(R)-lactate ligase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Meziane-Cherif, D.; Badet-Denisot, M.A.; Evers, S.; Courvalin, P.; Badet, B.
Purification and characterization of the VanB ligase associated with type B vancomycin resistance in Enterococcus faecalis V583
FEBS Lett.
354
140-142
1994
Enterococcus faecalis
Perichon, B.; Casadewall, B.; Reynolds, P.; Courvalin, P.
Glycopeptide-resistant Enterococcus faecium BM4416 is a VanD-type strain with an impaired D-alanine:D-alanine ligase
Antimicrob. Agents Chemother.
44
1346-1348
2000
Enterococcus faecium, Enterococcus faecium BM4416
Sova, M.; Cadez, G.; Turk, S.; Majce, V.; Polanc, S.; Batson, S.; Lloyd, A.J.; Roper, D.I.; Fishwick, C.W.; Gobec, S.
Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB)
Bioorg. Med. Chem. Lett.
19
1376-1379
2009
Enterococcus faecium
Neuhaus, F.C.
Role of Arg301 in substrate orientation and catalysis in subsite 2 of D-alanine:D-alanine (D-lactate) ligase from Leuconostoc mesenteroides: A molecular docking study
J. Mol. Graph. Model.
28
728-734
2010
Leuconostoc mesenteroides
Huyton, T.; Roper, D.I.
Crystallization and preliminary X-ray characterization of VanA from Enterococcus faecium BM4147: towards the molecular basis of bacterial resistance to the glycopeptide antibiotic vancomycin
Acta Crystallogr. Sect. D
55
1481-1483
1999
Enterococcus faecium
Perichon, B.; Reynolds, P.; Courvalin, P.
VanD-type glycopeptide-resistant Enterococcus faecium BM4339
Antimicrob. Agents Chemother.
41
2016-2018
1997
Enterococcus faecium, Enterococcus faecium BM4339
Dalla Costa, L.M.; Reynolds, P.E.; Souza, H.A.; Souza, D.C.; Palepou, M.F.; Woodford, N.
Characterization of a divergent vanD-type resistance element from the first glycopeptide-resistant strain of Enterococcus faecium isolated in Brazil
Antimicrob. Agents Chemother.
44
3444-3446
2000
Enterococcus faecium, Enterococcus faecium 10/96A
San Millan, A.; Depardieu, F.; Godreuil, S.; Courvalin, P.
VanB-type Enterococcus faecium clinical isolate successively inducibly resistant to, dependent on, and constitutively resistant to vancomycin
Antimicrob. Agents Chemother.
53
1974-1982
2009
Enterococcus faecium, Enterococcus faecium BM 4660
Bugg, T.D.; Wright, G.D.; Dutka-Malen, S.; Arthur, M.; Courvalin, P.; Walsh, C.T.
Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA
Biochemistry
30
10408-10415
1991
Enterococcus faecium, Enterococcus faecium BM4147
Park, I.-S.; Lin, C.-H.; Walsh, C.T.
Gain of D-alanyl-D-lactate or D-lactyl-D-alanine synthetase activities in three active-site mutants of the Escherichia coli D-alanyl-D-alanine ligase B
Biochemistry
35
10464-10471
1996
Escherichia coli
Healy, V.L.; Mullins, L.S.; Li, X.; Hall, S.E.; Raushel, F.M.; Walsh, C.T.
D-AlaD-X ligases: evaluation of D-alanyl phosphate intermediate by MIX, PIX and rapid quench studies
Chem. Biol.
7
505-514
2000
Enterococcus faecium
Nakagawa, T.; Satake, R.; Sato, M.; Kino, K.
Structure-based modification of D-alanine-D-alanine ligase from Thermotoga maritima ATCC 43589 for depsipeptide synthesis
Biosci. Biotechnol. Biochem.
75
700-704
2011
Thermotoga maritima, Thermotoga maritima ATCC 43589
Meziane-Cherif, D.; Saul, F.A.; Moubareck, C.; Weber, P.; Haouz, A.; Courvalin, P.; Perichon, B.
Molecular basis of vancomycin dependence in VanA-type Staphylococcus aureus VRSA-9
J. Bacteriol.
192
5465-5471
2010
Staphylococcus aureus, Staphylococcus aureus VRSA-9
Bisicchia, P.; Bui, N.K.; Aldridge, C.; Vollmer, W.; Devine, K.M.
Acquisition of VanB-type vancomycin resistance by Bacillus subtilis: the impact on gene expression, cell wall composition and morphology
Mol. Microbiol.
81
157-178
2011
Bacillus subtilis, Bacillus subtilis 168
Bouvier, G.; Duclert-Savatier, N.; Desdouits, N.; Meziane-Cherif, D.; Blondel, A.; Courvalin, P.; Nilges, M.; Malliavin, T.E.
Functional motions modulating VanA ligand binding unraveled by self-organizing maps
J. Chem. Inf. Model.
54
289-301
2014
Enterococcus faecium (P25051), Enterococcus faecium, Enterococcus faecium BM4147 (P25051)
Neuhaus, F.C.
Role of the omega loop in specificity determination in subsite 2 of the D-alanine:D-alanine (D-lactate) ligase from Leuconostoc mesenteroides: a molecular docking study
J. Mol. Graph. Model.
30
31-37
2011
Leuconostoc mesenteroides
Van Der Aart, L.; Lemmens, N.; Van Wamel, W.; Van Wezel, G.
Substrate inhibition of VanA by D-alanine reduces vancomycin resistance in a VanX-dependent manner
Antimicrob. Agents Chemother.
60
4930-4939
2016
Streptomyces coelicolor, Streptomyces coelicolor M145
Nakipoglu, M.; Yilmaz, F.; Icgen, B.
vanA Gene harboring enterococcal and non-enterococcal isolates expressing high level vancomycin and teicoplanin resistance reservoired in surface waters
Bull. Environ. Contam. Toxicol.
98
712-719
2017
Comamonas testosteroni, Enterococcus faecalis, Enterococcus faecium, Raoultella planticola, Pseudomonas fluorescens, Pseudomonas plecoglossicida, Pseudomonas koreensis, Enterococcus faecalis Cr07, Comamonas testosteroni Ni11, Enterococcus faecium 330, Pseudomonas plecoglossicida Ag10, Pseudomonas koreensis Hg11, Pseudomonas koreensis Hg10, Pseudomonas fluorescens SDS3, Enterococcus faecalis Pb06, Enterococcus faecalis E07, Raoultella planticola Ag11, Pseudomonas koreensis Cu12
html completed
