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Information on EC - O-phospho-L-serine-tRNA ligase

for references in articles please use BRENDA:EC6.1.1.27
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IUBMB Comments
In organisms like Archaeoglobus fulgidus lacking EC (cysteine---tRNA ligase) for the direct Cys-tRNACys formation, Cys-tRNACys is produced by an indirect pathway, in which EC (O-phosphoseryl-tRNA ligase) ligates O-phosphoserine to tRNACys, and EC (O-phospho-L-seryl-tRNA: Cys-tRNA synthase) converts the produced O-phospho-L-seryl-tRNACys to Cys-tRNACys. The SepRS/SepCysS pathway is the sole route for cysteine biosynthesis in the organism . Methanosarcina mazei can use both pathways, the direct route using EC (cysteine---tRNA ligase) and the indirect pathway with EC and EC (O-phospho-L-seryl-tRNA: Cys-tRNA synthase) .
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The expected taxonomic range for this enzyme is: Archaea, Bacteria
CysRS, Cysteinyl-tRNA synthetase, More, O-phosphoseryl-tRNA synthetase, phosphoseryl-tRNA synthetase, phosphoseryl-tRNA synthetases, SepRS, sepS, more
ATP + O-phospho-L-serine + tRNACys = AMP + diphosphate + O-phospho-L-seryl-tRNACys
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