Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 6.1.1.11 - serine-tRNA ligase and Organism(s) Mus musculus and UniProt Accession Q9JJL8

for references in articles please use BRENDA:EC6.1.1.11
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
This enzyme also recognizes tRNASec, the special tRNA for selenocysteine, and catalyses the formation of L-seryl-tRNASec, the substrate for EC 2.9.1.1, L-seryl-tRNASec selenium transferase.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Mus musculus
UNIPROT: Q9JJL8
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
serrs, seryl-trna synthetase, seryl trna synthetase, mtserrs, serrs2, seryl-trna-synthetase, mmbserrs, serzmo, serrs1, methanogenic serrs, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
62 kDa RNA-binding protein
-
Serine transfer RNA synthetase
-
Serine translase
-
Serine--tRNA ligase
-
Seryl-transfer ribonucleate synthetase
-
Seryl-transfer ribonucleic acid synthetase
-
Seryl-transfer RNA synthetase
-
Seryl-tRNA synthetase
-
Synthetase, seryl-transfer ribonucleate
-
62 kDa RNA-binding protein
-
-
-
-
Serine transfer RNA synthetase
-
-
-
-
Serine translase
-
-
-
-
Serine--tRNA ligase
-
-
-
-
SerRS
-
-
-
-
SerRSmt
-
-
-
-
SERSEC
-
-
-
-
Seryl-transfer ribonucleate synthetase
-
-
-
-
Seryl-transfer ribonucleic acid synthetase
-
-
-
-
Seryl-transfer RNA synthetase
-
-
-
-
Seryl-tRNA synthetase
-
-
-
-
Synthetase, seryl-transfer ribonucleate
-
-
-
-
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + L-serine + tRNASer = AMP + diphosphate + L-seryl-tRNASer
show the reaction diagram
the tRNA recognition mechanism of mammalian mitochondrial enzyme differs considerably from that of its prokaryotic counterpart
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
esterification
-
Aminoacylation
-
esterification
-
-
-
-
Aminoacylation
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -
SYSTEMATIC NAME
IUBMB Comments
L-serine:tRNASer ligase (AMP-forming)
This enzyme also recognizes tRNASec, the special tRNA for selenocysteine, and catalyses the formation of L-seryl-tRNASec, the substrate for EC 2.9.1.1, L-seryl-tRNASec selenium transferase.
CAS REGISTRY NUMBER
COMMENTARY hide
9023-48-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
show the reaction diagram
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + L-serine + tRNASer
AMP + diphosphate + L-seryl-tRNASer
show the reaction diagram
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
expression at low level
Manually annotated by BRENDA team
high expression
Manually annotated by BRENDA team
high expression
Manually annotated by BRENDA team
high expression
Manually annotated by BRENDA team
low expression
Manually annotated by BRENDA team
expression at low level
Manually annotated by BRENDA team
low expression
Manually annotated by BRENDA team
low expression
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SYSM_MOUSE
518
0
58316
Swiss-Prot
Mitochondrion (Reliability: 1)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
DNA and amino acid sequence determination and analysis
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yokogawa, T.; Shimada, N.; Takeuchi, N.; Benkowski, L.; Suzuki, T.; Omori, A.; Ueda, T.; Nishikawa, K.; Spremulli, L.L.; Watanabe, K.
Characterization and tRNA recognition of mammalian mitochondrial seryl-tRNA synthetase
J. Biol. Chem.
275
19913-19920
2000
Mus musculus (Q9JJL8), Mus musculus, Bos taurus (Q9N0F3), Bos taurus, Homo sapiens (Q9NP81), Homo sapiens
Manually annotated by BRENDA team
Gibbons, W.J., Jr.; Yan, Q.; Li, R.; Li, X.; Guan, M.X.
Genomic organization, expression, and subcellular localization of mouse mitochondrial seryl-tRNA synthetase
Biochem. Biophys. Res. Commun.
317
774-778
2004
Mus musculus (Q9JJL8), Mus musculus
Manually annotated by BRENDA team