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Abortion, Spontaneous
Placental ATPase expression is a link between multiple causes of spontaneous abortion in mice.
Abortion, Spontaneous
[An ultrastructural and ultracytochemical study of peripheral blood thrombocytes in women with habitual spontaneous abortion]
Achlorhydria
Mutation of the gastric hydrogen-potassium ATPase alpha subunit causes iron-deficiency anemia in mice.
Acidosis
Acidosis and Phosphate Directly Reduce Myosin's Force-Generating Capacity Through Distinct Molecular Mechanisms.
Acidosis
Acidosis has no effect on the ATP cost of contraction in cat fast- and slow-twitch skeletal muscles.
Acidosis
Altered V-ATPase expression in renal intercalated cells isolated from B1 subunit-deficient mice by fluorescence-activated cell sorting.
Acidosis
Bicarbonate-activated ATPase activity in renal cortex of chronically acidotic rats.
Acidosis
Characterization and regulation of H-K-ATPase in intercalated cells of rabbit cortical collecting duct.
Acidosis
Characterization of cardiac sarcoplasmic reticulum dysfunction during short-term, normothermic, global ischemia.
Acidosis
Characterization of the effect of pH on the excitation-contraction coupling system of canine masseter muscle.
Acidosis
Chronic extracellular acidosis induces plasmalemmal vacuolar type H+ ATPase activity in osteoclasts.
Acidosis
Coupling of energy failure and dissipative K+ flux during ischemia: role of preischemic plasma glucose concentration.
Acidosis
Diseases of renal adenosine triphosphatase.
Acidosis
Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis.
Acidosis
Effect of metabolic acidosis and alkalosis on NEM-sensitive ATPase in rat nephron segments.
Acidosis
Genetic investigation of autosomal recessive distal renal tubular acidosis: evidence for early sensorineural hearing loss associated with mutations in the ATP6V0A4 gene.
Acidosis
H+ transport and membrane-bound HCO - 3 ATPase in salivary duct epithelium.
Acidosis
Intracellular protons accelerate aging and switch on aging hallmarks in mice.
Acidosis
Ischemic preconditioning reduces Na(+) accumulation and cell killing in isolated rat hepatocytes exposed to hypoxia.
Acidosis
Ligand-gated channel of the sarcoplasmic reticulum Ca2+ transport ATPase.
Acidosis
NEM-sensitive ATPase activity in rat nephron: effect of metabolic acidosis and alkalosis.
Acidosis
Preconditioning rabbit cardiomyocytes: role of pH, vacuolar proton ATPase, and apoptosis.
Acidosis
Protonic inhibition of the mitochondrial oligomycin-sensitive adenosine 5'-triphosphatase in ischemic and autolyzing cardiac muscle. Possible mechanism for the mitigation of ATP hydrolysis under nonenergizing conditions.
Acidosis
Regulation of the mitochondrial adenosine 5'-triphosphatase in situ during ischemia and in vitro in intact and sonicated mitochondria from slow and fast heart-rate hearts.
Acidosis
Stimulation of an N-ethylmaleimide-sensitive ATPase in the collecting duct segments of the rat nephron by metabolic acidosis.
Acidosis
Systemic lupus erythematosus presenting initially as hydrogen ATPase pump defects of distal renal tubular acidosis.
Acidosis
The effect of short term normothermic global ischemia and acidosis on cardiac myofibrillar Ca2+-Mg2+ ATPase activity.
Acidosis
The mitochondrial adenosine 5'-triphosphatase in slow and fast heart rate hearts.
Acidosis
V-type ATPase proton pump expression during enamel formation.
Acidosis
Whole exome sequencing identified ATP6V1C2 as a novel candidate gene for recessive distal renal tubular acidosis.
Acidosis, Renal Tubular
Diseases of renal adenosine triphosphatase.
Acidosis, Renal Tubular
Genetic investigation of autosomal recessive distal renal tubular acidosis: evidence for early sensorineural hearing loss associated with mutations in the ATP6V0A4 gene.
Acidosis, Renal Tubular
Systemic lupus erythematosus presenting initially as hydrogen ATPase pump defects of distal renal tubular acidosis.
Acidosis, Renal Tubular
V-type ATPase proton pump expression during enamel formation.
Acidosis, Renal Tubular
Whole exome sequencing identified ATP6V1C2 as a novel candidate gene for recessive distal renal tubular acidosis.
Acquired Immunodeficiency Syndrome
Condensin aids sister chromatid decatenation by topoisomerase II.
Acquired Immunodeficiency Syndrome
Digoxin : a model for hypothalamic regulation of neuronal transmission, endocrine function, immunity and cytodifferentiation.
Acquired Immunodeficiency Syndrome
Hsp70's RNA-binding and mRNA-stabilizing activities are independent of its protein chaperone functions.
Acquired Immunodeficiency Syndrome
Reduced Langerhans' cell Ia antigen and ATPase activity in patients with the acquired immunodeficiency syndrome.
Acquired Immunodeficiency Syndrome
Topoisomerase II inhibitor induced leukemia in a patient with AIDS.
Acquired Immunodeficiency Syndrome
[Ciprofloxacin in Salmonella infection and abdominal typhoid]
Acute Kidney Injury
Acute renal failure after folate: NaK ATPase in isolated rat renal tubule. Ultramicrochemical and clinical studies.
Acute Kidney Injury
Changes in 25-hydroxyvitamin D3 alpha- and 24-hydroxylase activities of kidney cells isolated from rats with either unilateral kidney damage or acute renal insufficiency.
Acute Kidney Injury
The pathophysiology of septic shock: acute renal failure in rats following live E coli injection. A histochemical study of the proximal tubules.
Acute Kidney Injury
[Function of the kidneys and ATPase activity in them in nephrotic acute renal insufficiency]
Acute Lung Injury
Endogenous Na/K ATPase inhibitor ouabain in critically ill children with lung injury.
Acute Lung Injury
Upregulation of endothelial cell-derived exosomal microRNA-125b-5p protects from sepsis-induced acute lung injury by inhibiting topoisomerase II alpha.
Adenocarcinoma
(Na (+) + K (+)-stimulated ATPase of human kidney, normal and adenocarcinoma. Phosphorylation and inhibition by antitumor proteins.
Adenocarcinoma
A subset of pancreatic adenocarcinomas demonstrates coamplification of topoisomerase IIalpha and HER2/neu: use of immunolabeling and multicolor FISH for potential patient screening andtreatment.
Adenocarcinoma
Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIalpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab.
Adenocarcinoma
Amplification of the topoisomerase II alpha gene in a non-small cell lung cancer cell line and characterisation of polymorphisms at the human topoisomerase II alpha and beta loci in normal tissue.
Adenocarcinoma
Analysis of EGFR, HER2, and TOP2A gene status and chromosomal polysomy in gastric adenocarcinoma from Chinese patients.
Adenocarcinoma
Circumvention of confluence-dependent resistance in a human multi-drug-resistant colon-cancer cell line.
Adenocarcinoma
Claudin-4, mitogen-activated protein kinase kinase 4, and stratifin are markers of gastric adenocarcinoma precursor lesions.
Adenocarcinoma
Comprehensive Biomarkers for Personalized Treatment in Pulmonary Large Cell Neuroendocrine Carcinoma: A Comparative Analysis With Adenocarcinoma.
Adenocarcinoma
Differential expression of topoisomerase IIalpha protein in salivary gland carcinomas: histogenetic and prognostic implications.
Adenocarcinoma
Dual functions of a monoclonal antibody against cell surface F1F0 ATP synthase on both HUVEC and tumor cells.
Adenocarcinoma
Effects of inhibitors of topoisomerases-I and topoisomerases-ii on DNA methylation and DNA-synthesis in human colonic adenocarcinoma cells-invitro.
Adenocarcinoma
Erybraedin C and bitucarpin A, two structurally related pterocarpans purified from Bituminaria bituminosa, induced apoptosis in human colon adenocarcinoma cell lines MMR- and p53-proficient and -deficient in a dose-, time-, and structure-dependent fashion.
Adenocarcinoma
Etoposide-resistant human colon and lung adenocarcinoma cell lines exhibit sensitivity to homoharringtonine.
Adenocarcinoma
Evaluation of topoisomerase IIa expression in pancreatic ductal adenocarcinoma: a pilot study using chromogenic in situ hybridization and immunohistochemistry on tissue microarrays.
Adenocarcinoma
Expression Analysis of Barrett's Esophagus-Associated High-Grade Dysplasia in Laser Capture Microdissected Archival Tissue.
Adenocarcinoma
Expression and potential roles of sodium-potassium ATPase and E-cadherin in human gastric adenocarcinoma.
Adenocarcinoma
Expression of multidrug resistance-related proteins p-glycoprotein, glutathione-s-transferases, topoisomerase-II and lung resistance protein in primary gastric cardiac adenocarcinoma.
Adenocarcinoma
Expression of multidrug-resistance-related proteins P-glycoprotein, glutathione-S-transferases, topoisomerase-II and lung resistance protein in primary gastric cardiac adenocarcinoma.
Adenocarcinoma
Expression of topoisomerase II alpha and beta in an adenocarcinoma cell line carrying amplified topoisomerase II alpha and retinoic acid receptor alpha genes.
Adenocarcinoma
Growth-related elevations of DNA topoisomerase II levels found in Dunning R3327 rat prostatic adenocarcinomas.
Adenocarcinoma
HER2/Topoisomerase IIa co-amplified breast adenocarcinoma "mirror" cases with different Topoisomerase IIa expression patterns.
Adenocarcinoma
Human SWI-SNF component BRG1 represses transcription of the c-fos gene.
Adenocarcinoma
Identification of Key Genes and Pathways in Pancreatic Cancer Gene Expression Profile by Integrative Analysis.
Adenocarcinoma
Identification of potential crucial genes associated with the pathogenesis and prognosis of pancreatic adenocarcinoma.
Adenocarcinoma
Identification of tumor-associated antigens of lung cancer: SEREX combined with bioinformatics analysis.
Adenocarcinoma
Immunohistochemical detection of human telomerase reverse transcriptase (hTERT), topoisomerase IIalpha expression, and apoptosis in endometrial adenocarcinoma and atypical hyperplasia.
Adenocarcinoma
Immunohistochemical expression of topoisomerase IIalpha (Topo IIalpha) and multidrug resistance-associated protein (MRP), plus chemosensitivity testing, as chemotherapeutic indices of ovarian and endometrial carcinomas.
Adenocarcinoma
Immunohistochemical localization of sodium-potassium ATPase in human normal stomach and gastric adenocarcinomas.
Adenocarcinoma
Immunohistochemical staining for DNA topoisomerase II-alpha in benign, premalignant, and malignant lesions of the prostate.
Adenocarcinoma
Immunohistochemical study of DNA topoisomerase II in human gastric disorders.
Adenocarcinoma
Immunohistochemical study of Ki-67 and DNA topoisomerase II in human endometrium.
Adenocarcinoma
Interaction of angiotensin II type 1 receptor blockers with P-gp substrates in Caco-2 cells and hMDR1-expressing membranes.
Adenocarcinoma
Molecular analysis of the topoisomerase II alpha gene and its expression in human ovarian cancer.
Adenocarcinoma
Newly replicated DNA is associated with DNA topoisomerase II in cultured rat prostatic adenocarcinoma cells.
Adenocarcinoma
Plasma membrane calcium ATPase expression in human colon multistep carcinogenesis.
Adenocarcinoma
Prognostic value of FHIT, CTNNB1, and MUC1 expression in non-small cell lung cancer.
Adenocarcinoma
Sensitivity to TOP2 Targeting Chemotherapeutics Is Regulated by Oct1 and FILIP1L.
Adenocarcinoma
Simultaneous quantitation of topoisomerase II alpha and beta isoform mRNAs in lung tumor cells and normal and malignant lung tissue.
Adenocarcinoma
Structural aspects of mammalian DNA replication: topoisomerase II.
Adenocarcinoma
Targeting topoisomerase IIa in endometrial adenocarcinoma: a combined chromogenic in situ hybridization and immunohistochemistry study based on tissue microarrays.
Adenocarcinoma
Thallium-201 uptake, histopathological differentiation and Na-K ATPase in lung adenocarcinoma.
Adenocarcinoma
The Vacuolar H+ ATPase ?3 Subunit Negatively Regulates Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cells.
Adenocarcinoma
Tissue microarray analysis of topoisomerase IIalpha protein in gastric adenocarcinomas: histogenetic and prognostic implications.
Adenocarcinoma
TOPOIIalpha and HER-2/neu overexpression/amplification in Barrett's oesophagus, dysplasia and adenocarcinoma.
Adenocarcinoma
Topoisomerase IIa protein expression analysis in oral squamous cell carcinoma.
Adenocarcinoma
Topoisomerase IIa Protein Expression Patterns in Laryngeal Squamous Cell Carcinoma.
Adenocarcinoma
Topoisomerase IIalpha gene amplification in gastric carcinomas: correlation with the HER2 gene. An immunohistochemical, immunoblotting, and multicolor fluorescence in situ hybridization study.
Adenocarcinoma
Topoisomerase IIalpha gene expression is regulated by the p53 tumor suppressor gene in nonsmall cell lung carcinoma patients.
Adenocarcinoma
[Construction of eukaryotic expression plasmid pEGFP-ATP1B1 and its effect on gastric adenocarcinoma cell SGC-7901]
Adenocarcinoma
[Correlation between aneuploidy of chromosome 17, over-expression of TP53 and TOPIIalpha, and the clinicopathological features and diagnosis of gastric adenocarcinoma]
Adenocarcinoma
[Study on the relationship among multidrug resistance factor expression of lung cancer tissues and clinicopathological characteristics in patients with lung cancer.]
Adenocarcinoma
[The proliferative properties and regulators of the mitotic cell cycle of prostate adenocarcinoma]
Adenocarcinoma
[Topoisomerase IIalpha and HER2/neu gene alterations and their correlation in pancreatic ductal adenocarcinomas]
Adenocarcinoma of Lung
A comparative and integrative approach identifies ATPase family, AAA domain containing 2 as a likely driver of cell proliferation in lung adenocarcinoma.
Adenocarcinoma of Lung
ATPase family AAA domain-containing 3A is a novel anti-apoptotic factor in lung adenocarcinoma cells.
Adenocarcinoma of Lung
B1, a novel topoisomerase II inhibitor, induces apoptosis and cell cycle G1 arrest in lung adenocarcinoma A549 cells.
Adenocarcinoma of Lung
Differential molecular markers of primary lung tumors and metastatic sites indicate different possible treatment selections in patients with metastatic lung adenocarcinoma.
Adenocarcinoma of Lung
Drug-induced DNA hypermethylation and drug resistance in human tumors.
Adenocarcinoma of Lung
Elevated TOP2A and UBE2C expressions correlate with poor prognosis in patients with surgically resected lung adenocarcinoma: a study based on immunohistochemical analysis and bioinformatics.
Adenocarcinoma of Lung
Enhancement of radiosensitivity by topoisomerase II inhibitor, amrubicin and amrubicinol, in human lung adenocarcinoma A549 cells and kinetics of apoptosis and necrosis induction.
Adenocarcinoma of Lung
Establishment and characteristics of a human lung adenocarcinoma cell line.
Adenocarcinoma of Lung
Experimental solid tumour activity of N-[2-(dimethylamino)ethyl]-acridine-4-carboxamide.
Adenocarcinoma of Lung
Expression of the Topoisomerase II Alpha (TOP2A) Gene in Lung Adenocarcinoma Cells and the Association with Patient Outcomes.
Adenocarcinoma of Lung
Expression of topoisomerase II alpha and beta in an adenocarcinoma cell line carrying amplified topoisomerase II alpha and retinoic acid receptor alpha genes.
Adenocarcinoma of Lung
Global Regulatory DNA Potentiation by SMARCA4 Propagates to Selective Gene Expression Programs via Domain-Level Remodeling.
Adenocarcinoma of Lung
Identification of chromosomal loci associated with non-P-glycoprotein-mediated multidrug resistance to topoisomerase II inhibitor in lung adenocarcinoma cell line by comparative genomic hybridization.
Adenocarcinoma of Lung
Identification of differentially expressed protein-coding genes in lung adenocarcinomas.
Adenocarcinoma of Lung
Identifying Tumorigenesis and Prognosis-Related Genes of Lung Adenocarcinoma: Based on Weighted Gene Coexpression Network Analysis.
Adenocarcinoma of Lung
Mining expression and prognosis of topoisomerase isoforms in non-small-cell lung cancer by using Oncomine and Kaplan-Meier plotter.
Adenocarcinoma of Lung
Quantitative immunocytochemical assays of topoisomerase II in lung adenocarcinoma cell lines. Correlation to topoisomerase II alpha content and topoisomerase II catalytic activity.
Adenocarcinoma of Lung
Thallium-201 uptake, histopathological differentiation and Na-K ATPase in lung adenocarcinoma.
Adenocarcinoma of Lung
TOP2A Promotes Lung Adenocarcinoma Cells' Malignant Progression and Predicts Poor Prognosis in Lung Adenocarcinoma.
Adenocarcinoma of Lung
[Topoisomerase IIa expression in correlation with clinical and morphological parameters and proliferation (based on argyrophilic proteins of nucleolar organizer regions and Ki-67 antigen) in lung adenocarcinoma].
Adenocarcinoma, Clear Cell
Immunohistochemical expression of topoisomerase IIalpha (Topo IIalpha) and multidrug resistance-associated protein (MRP), plus chemosensitivity testing, as chemotherapeutic indices of ovarian and endometrial carcinomas.
Adenolymphoma
[The mechanism of positive scintigraphy with 99mTc-pertechnetate in adenolymphomas of the parotid grand]
Adenoma
Clinical and Steroidogenic Characteristics of Aldosterone-Producing Adenomas With ATPase or CACNA1D Gene Mutations.
Adenoma
Cyclins D1 and D3 and topoisomerase II alpha in inactive pituitary adenomas.
Adenoma
DNA topoisomerase II alpha and Ki-67 in human adrenocortical neoplasms: a possible marker of differentiation between adenomas and carcinomas.
Adenoma
Expression of cell proliferation markers in pituitary adenomas--correlation and clinical relevance of MIB-1 and anti-topoisomerase-IIalpha.
Adenoma
Frequencies of mtDNA mutations in primary tissues of colorectal adenopolyps.
Adenoma
Immunohistochemical analysis of the distribution of the human ATPase (hASNA-I) in normal tissues and its overexpression in breast adenomas and carcinomas.
Adenoma
Immunohistochemical expression of TopBP1 in feline mammary neoplasia in relation to histological grade, Ki67, ERalpha and p53.
Adenoma
Immunohistochemical study of DNA topoisomerase II in human gastric disorders.
Adenoma
Plasma membrane calcium ATPase expression in human colon multistep carcinogenesis.
Adenoma
Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension.
Adenoma
Somatic mutations of the ATP1A1 gene and aldosterone-producing adenomas.
Adenoma
Topoisomerase IIalpha expression in pituitary adenomas and carcinomas: relationship to tumor behavior.
Adenoma, Oxyphilic
Mitochondrial adenosine triphosphatase in the oxyphil cells of a renal oncocytoma.
Adenoma, Pleomorphic
Aggressive silent corticotroph adenoma progressing to pituitary carcinoma: the role of temozolomide therapy.
Adenoma, Pleomorphic
Differential expression of topoisomerase IIalpha protein in salivary gland carcinomas: histogenetic and prognostic implications.
Adenoma, Pleomorphic
Immunohistochemical detection of DNA topoisomerase type II alpha and Ki-67 in adenoid cystic carcinoma and pleomorphic adenoma of the salivary gland.
Adenoma, Pleomorphic
Phosphatase enzymes. Cytochemical study of pleomorphic adenoma and normal human salivary glands.
Adenoma, Pleomorphic
[The role of stromal components and Ca++ ATPase in pleomorphic adenoma and adenoid cystic carcinoma]
Adenomatous Polyposis Coli
Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complex.
Adenomatous Polyposis Coli
Human homologue of the Drosophila discs large tumor suppressor protein forms an oligomer in solution. Identification of the self-association site.
Adenomatous Polyposis Coli
Interaction between tumor suppressor adenomatous polyposis coli and topoisomerase IIalpha: implication for the G2/M transition.
Adenomatous Polyposis Coli
Therapeutic Targeting of Nuclear Export Inhibition in Lung Cancer.
Adenomatous Polyposis Coli
Topoisomerase IIalpha binding domains of adenomatous polyposis coli influence cell cycle progression and aneuploidy.
Adenomatous Polyps
INO80 haploinsufficiency inhibits colon cancer tumorigenesis via replication stress-induced apoptosis.
Adrenal Insufficiency
Specific activity and sensitivity of strophanthin of the Na + +K + -activated ATPase in rats and guinea-pigs with hypoadrenalism.
Adrenocortical Adenoma
DNA topoisomerase II alpha and Ki-67 in human adrenocortical neoplasms: a possible marker of differentiation between adenomas and carcinomas.
Adrenocortical Carcinoma
TOP2A is overexpressed and a therapeutic target for adrenocortical carcinoma.
Adrenocortical Carcinoma
Topoisomerase 2? and thymidylate synthase expression in adrenocortical cancer.
African Swine Fever
A gene homologous to topoisomerase II in African swine fever virus.
African Swine Fever
African swine fever virus ORF P1192R codes for a functional type II DNA topoisomerase.
African Swine Fever
Evidence for the evolution of ascoviruses from iridoviruses.
African Swine Fever
Functional characterization and inhibition of the type II DNA topoisomerase coded by African swine fever virus.
African Swine Fever
The African Swine Fever Virus (ASFV) Topoisomerase II as a Target for Viral Prevention and Control.
Albinism
[Variation in evolutionary unstable regions of the chloroplast genome in plants obtained in anther culture of dihaploid wheat lines]
Alkalosis
Bicarbonate-sensing soluble adenylyl cyclase is present in the cell cytoplasm and nucleus of multiple shark tissues.
Alkalosis
Decrease in N-ethylmaleimide-sensitive ATPase activity in collecting duct by metabolic alkalosis.
Alkalosis
Effect of metabolic acidosis and alkalosis on NEM-sensitive ATPase in rat nephron segments.
Alkalosis
H+ transport and membrane-bound HCO - 3 ATPase in salivary duct epithelium.
Alkalosis
Na/H exchange and H-K ATPase increase distal tubule acidification in chronic alkalosis.
Alkalosis
NEM-sensitive ATPase activity in rat nephron: effect of metabolic acidosis and alkalosis.
Alkalosis
Vanadate stimulates the N-ethylmaleimide-sensitive adenosine triphosphatase in rat nephron.
Alopecia
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Alternariosis
Polyphasic identification of three new species in Alternaria section Infectoriae causing human cutaneous infection.
Altitude Sickness
Effect of altitude hypoxia on ATPase activity in the brain of rats of different ages.
Alzheimer Disease
Downregulation of ATP6V1A Involved in Alzheimer's Disease via Synaptic Vesicle Cycle, Phagosome, and Oxidative Phosphorylation.
Alzheimer Disease
Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease.
Alzheimer Disease
Na(+) and K(+) ion imbalances in Alzheimer's disease.
Alzheimer Disease
Pathological lesions of Alzheimer's disease and dementia with Lewy bodies brains exhibit immunoreactivity to an ATPase that is a regulatory subunit of the 26S proteasome.
Alzheimer Disease
PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis.
Alzheimer Disease
Upregulation of the Sarco-Endoplasmic Reticulum Calcium ATPase 1 Truncated Isoform Plays a Pathogenic Role in Alzheimer's Disease.
Ameloblastoma
Detection of cell cycle-related factors in ameloblastomas.
Amnesia
Cholinergic receptor antagonists impair formation of intermediate-term memory in the chick.
Amyloidosis
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Amyotrophic Lateral Sclerosis
An ?2-Na/K ATPase/?-adducin complex in astrocytes triggers non-cell autonomous neurodegeneration.
Amyotrophic Lateral Sclerosis
C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.
Amyotrophic Lateral Sclerosis
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Anaplasia
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Anaplasmosis
ATPase activity of the erythrocytic membrane in anaplasmosis and of Anaplasma marginale.
Anaplasmosis
Erythrocyte osmotic fragility and cation concentrations during experimentally induced bovine anaplasmosis.
Anemia
Abnormalities in adenosine triphosphatase of the erythrocyte membrane in iron deficiency anaemia.
Anemia
Alterations of erythrocyte ATPase activity and oxygen consumption in patients with liver-blood deficiency syndrome.
Anemia
Alternate reasons for atherogenesis in uremia.
Anemia
Cardiovascular complications in end-stage renal disease and hemodialysis patients.
Anemia
Comparative action of calpain on erythrocyte Ca2(+)-pumping ATPase in sickle cell anaemia, essential hypertension and kwashiorkor.
Anemia
Erythrocyte membrane enzymes in sickle cell anemia. 2. Acetylcholinesterase and ATPase activities.
Anemia
Increased Ca++, Mg++, and Na+ + K+ ATPase activities in erythrocytes of sickle cell anemia.
Anemia
Kinetic alterations of the red cell membrane phosphatase in alpha- and beta-thalassemia.
Anemia
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Anemia
The Levels of Sera Malondialdehyde, Erythrocyte Membrane Na+-K+/Mg++ and Ca++/Mg++ Adenosine 5' Triphosphatase in Patients with Sickle Cell Anemia.
Anemia
Variations in the relative activities of erythrocyte membrane ATPase with changes in severity of sickle cell anemia.
Anemia, Aplastic
Alterations of erythrocyte ATPase activity and oxygen consumption in patients with liver-blood deficiency syndrome.
Anemia, Aplastic
MLL-CBP fusion transcript in a therapy-related acute myeloid leukemia with the t(11;16)(q23;p13) which developed in an acute lymphoblastic leukemia patient with Fanconi anemia.
Anemia, Hemolytic
Enzymatic pattern of glucose metabolic pathways in pyruvate kinase-deficient erythrocytes.
Anemia, Hemolytic
The activity of the red blood cell Ca pump is decreased in hemolytic anemia of the beagle dog.
Anemia, Hemolytic, Congenital
Identification and functional analyses of disease-associated P4-ATPase phospholipid flippase variants in red blood cells.
Anemia, Hemolytic, Congenital
Intra-erythrocytary enzymes before and after splenectomy.
Anemia, Iron-Deficiency
Abnormalities in adenosine triphosphatase of the erythrocyte membrane in iron deficiency anaemia.
Anemia, Iron-Deficiency
Alterations of erythrocyte ATPase activity and oxygen consumption in patients with liver-blood deficiency syndrome.
Anemia, Iron-Deficiency
Mutation of the gastric hydrogen-potassium ATPase alpha subunit causes iron-deficiency anemia in mice.
Anemia, Pernicious
An autoimmune disease with multiple molecular targets abrogated by the transgenic expression of a single autoantigen in the thymus.
Anemia, Sickle Cell
Comparative action of calpain on erythrocyte Ca2(+)-pumping ATPase in sickle cell anaemia, essential hypertension and kwashiorkor.
Anemia, Sickle Cell
Erythrocyte membrane enzymes in sickle cell anemia. 2. Acetylcholinesterase and ATPase activities.
Anemia, Sickle Cell
Increased Ca++, Mg++, and Na+ + K+ ATPase activities in erythrocytes of sickle cell anemia.
Anemia, Sickle Cell
The Levels of Sera Malondialdehyde, Erythrocyte Membrane Na+-K+/Mg++ and Ca++/Mg++ Adenosine 5' Triphosphatase in Patients with Sickle Cell Anemia.
Anemia, Sickle Cell
Variations in the relative activities of erythrocyte membrane ATPase with changes in severity of sickle cell anemia.
Aneurysm
Effects of naloxone on sodium- and potassium-activated and magnesium-dependent adenosine-5'-triphosphatase activity and lipid peroxidation and early ultrastructural findings after experimental spinal cord injury.
Angelman Syndrome
The sodium-potassium ATPase emerges as a player in hippocampal phenotypes of Angelman syndrome mice.
Angina Pectoris
Increase in plasma digitalis-like activity during percutaneous transluminal coronary angioplasty in patients with coronary stenosis.
Anthrax
An essential DnaB helicase of Bacillus anthracis: identification, characterization, and mechanism of action.
Anthrax
Drug interactions with Bacillus anthracis topoisomerase IV: biochemical basis for quinolone action and resistance.
Anthrax
Interactions between Quinolones and Bacillus anthracis Gyrase and the Basis of Drug Resistance.
Aortic Coarctation
The relationship of a decline in myofibrillar ATP-ase activity to the development of severe left ventricular hypertrophy in the rat.
Aortic Valve Stenosis
Differential responses of canine myosin ATPase activity and tissue gases in the pressure-overloaded ventricle dependent upon degree of obstruction: mild versus severe pulmonic and aortic stenosis.
Aortic Valve Stenosis
Effect of chronic digoxin treatment on cardiac function, electrolytes and ATPase in failing heart due to pressure overload.
Aortic Valve Stenosis
Effect of prolonged prazosin treatment on hemodynamic and biochemical changes in the dog heart due to chronic pressure overload.
Aortic Valve Stenosis
Transgenic expression of sarcoplasmic reticulum Ca(2+) atpase modifies the transition from hypertrophy to early heart failure.
Apraxias
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Arrhythmias, Cardiac
Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain.
Arrhythmias, Cardiac
Exposure to low-level metalaxyl impacts the cardiac development and function of zebrafish embryos.
Arrhythmias, Cardiac
Targeted antioxidant treatment decreases cardiac alternans associated with chronic myocardial infarction.
Arrhythmias, Cardiac
[Animal in vivo model of arrhythmia for genes target identification for 5-amino-exo-3-azatricyclo[5.2.1.0(2,6)]decan-4-one].
Arrhythmias, Cardiac
[Pathogenetic characteristics of the development of arrhythmia in patients with ischemic heart disease]
Arteriosclerosis
[Alkaline phosphatase and ATPase activity in the walls of the cerebral vessels in hypertension and arteriosclerosis with disorders of the cerebral circulation]
Arteriosclerosis
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Arteritis
Coronavirus interactions with the cellular autophagy machinery.
Arthritis
Histochemical investigation of adjuvant-induced arthritis.
Arthritis
In vivo sortase A and clumping factor A mRNA expression during Staphylococcus aureus infection.
Arthritis
Topoisomerase II inhibitors, irrespective of their chemical composition, ameliorate experimental arthritis.
Arthritis
Total abrogation of collagen II-induced arthritis and the B cell response to type II collagen using suboptimal doses of a topoisomerase II antagonist.
Arthritis, Experimental
Differential display analysis of murine collagen-induced arthritis: cloning of the cDNA-encoding murine ATPase inhibitor.
Arthritis, Experimental
Topoisomerase II inhibitors, irrespective of their chemical composition, ameliorate experimental arthritis.
Arthritis, Juvenile
Autoantibodies to DNA topoisomerase II in juvenile rheumatoid arthritis.
Arthritis, Rheumatoid
Serum E-selectin and erythrocyte membrane Na+K+ ATPase levels in patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Sialic acid, transketolase and Na+, K+, ATPase in patients with rheumatoid arthritis.
Asthenozoospermia
Sperm Na(+), K(+)-ATPase ?4 and plasma membrane Ca(2+)-ATPase (PMCA) 4 regulation in asthenozoospermia.
Asthma
Adenosine and its role in asthma.
Asthma
Decreased sodium-potassium and calcium adenosine triphosphatase activity in asthma: modulation by inhaled and oral corticosteroids.
Asthma
In vitro modulation of platelet sodium, potassium adenosine triphosphatase enzyme activity by antiallergy drugs.
Asthma
Increased adenosine triphosphatase activity in platelets of asthmatic children.
Asthma
Leukocyte adenyl cyclase and ATPase in asthma: effect of corticosteroid therapy.
Asthma
The Role of Heat Shock Protein 70 kDa in Asthma.
Astrocytoma
Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction.
Astrocytoma
Distinct roles of Topoisomerase II isoforms: DNA damage accelerating alpha, double strand break repair promoting beta.
Astrocytoma
DNA topoisomerase II-alpha as a proliferation marker in astrocytic neoplasms of the central nervous system: correlation with MIB1 expression and patient survival.
Astrocytoma
Expression of Ki-67, topoisomerase IIalpha and c-MYC in astrocytic tumors: correlation with the histopathological grade and proliferative status.
Astrocytoma
High topoisomerase IIalpha expression associates with high proliferation rate and and poor prognosis in oligodendrogliomas.
Astrocytoma
Higher topoisomerase 2 alpha gene transcript levels predict better prognosis in GBM patients receiving temozolomide chemotherapy: identification of temozolomide as a TOP2A inhibitor.
Astrocytoma
Immunohistochemical staining of DNA topoisomerase IIalpha in human gliomas.
Astrocytoma
In situ detection of telomeres by fluorescence in situ hybridization and telomerase activity in glioblastoma multiforme: correlation with p53 status, EGFR, c-myc, MIB1, and Topoisomerase IIalpha protein expression.
Astrocytoma
Isolation and characterization of plasma membranes from transplantable human astrocytoma, oat cell carcinoma, and melanomas.
Astrocytoma
Mitosin and DNA topoisomerase IIalpha: two novel proliferation markers in the prognostication of diffuse astrocytoma patient survival.
Astrocytoma
Regulation of topoisomerase II alpha and beta in HIV-1 infected and uninfected neuroblastoma and astrocytoma cells: involvement of distinct nordihydroguaretic acid sensitive inflammatory pathways.
Astrocytoma
Reverse engineering of modified genes by bayesian network analysis defines molecular determinants critical to the development of glioblastoma.
Asymptomatic Infections
Submicroscopic and asymptomatic Plasmodium falciparum and Plasmodium vivax infections are common in western Thailand - molecular and serological evidence.
Ataxia
A calcium signaling defect in the pathogenesis of a mitochondrial DNA inherited oxidative phosphorylation deficiency.
Ataxia
Ataxia telangiectasia mutated-dependent regulation of topoisomerase II alpha expression and sensitivity to topoisomerase II inhibitor.
Ataxia
Catalytic activities of mitochondrial ATP synthase in patients with mitochondrial DNA T8993G mutation in the ATPase 6 gene encoding subunit a.
Ataxia
Diseases resulting from mitochondrial DNA point mutations.
Ataxia
Heterogeneous clinical presentation of the mtDNA NARP/T8993G mutation.
Ataxia
Heterogeneous patterns of tissue injury in NARP syndrome.
Ataxia
Ionizing radiation-induced foci persistence screen to discover enhancers of accelerated senescence.
Ataxia
Marked inhibition of Na+, K(+)- ATPase activity and the respiratory chain by phytanic acid in cerebellum from young rats: possible underlying mechanisms of cerebellar ataxia in Refsum disease.
Ataxia
Mitochondrial DNA background modifies the bioenergetics of NARP/MILS ATP6 mutant cells.
Ataxia
NARP Syndrome: A 20-Year Follow-Up.
Ataxia
Rad9A is required for the G2 decatenation checkpoint and to prevent endoreduplication in response to topoisomerase II inhibition.
Ataxia
Rescue of a deficiency in ATP synthesis by transfer of MTATP6, a mitochondrial DNA-encoded gene, to the nucleus.
Ataxia
Response of cell cycle/stress-related protein expression and DNA damage upon treatment of CaCo2 cells with anthocyanins.
Ataxia
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Ataxia
Synthesis and preliminary biological evaluations of ionic and nonionic amphiphilic alpha-phenyl-N-tert-butylnitrone derivatives.
Ataxia
The 8993 mtDNA mutation: heteroplasmy and clinical presentation in three families.
Ataxia
The aleu207-->arg mutation in F1F0-ATP synthase from Escherichia coli. A model for human mitochondrial disease.
Ataxia
The ataxia related G1107D mutation of the plasma membrane Ca(2+) ATPase isoform 3 affects its interplay with calmodulin and the autoinhibition process.
Ataxia
The neurogenic weakness, ataxia and retinitis pigmentosa (NARP) syndrome mtDNA mutation (T8993G) triggers muscle ATPase deficiency and hypocitrullinaemia.
Ataxia
The study of the pathogenic mechanism of mitochondrial diseases provides information on basic bioenergetics.
Ataxia Telangiectasia
A defect in DNA topoisomerase II activity in ataxia-telangiectasia cells.
Ataxia Telangiectasia
Action of etoposide (VP-16-123) on human cells: no evidence for topoisomerase II involvement in excision repair of u.v.-induced DNA damage, nor for mitochondrial hypersensitivity in ataxia telangiectasia.
Ataxia Telangiectasia
Ataxia telangiectasia mutated (ATM) interacts with p400 ATPase for an efficient DNA damage response.
Ataxia Telangiectasia
Ataxia telangiectasia mutated-dependent regulation of topoisomerase II alpha expression and sensitivity to topoisomerase II inhibitor.
Ataxia Telangiectasia
ATM-mediated phosphorylation of the chromatin remodeling enzyme BRG1 modulates DNA double-strand break repair.
Ataxia Telangiectasia
Cellular consequences of overproduction of DNA topoisomerase II in an ataxia-telangiectasia cell line.
Ataxia Telangiectasia
Defective DNA topoisomerase II in ataxia-telangiectasia cells.
Ataxia Telangiectasia
Human cells (normal and ataxia telangiectasia) transfected with pR plasmid are hypersensitive to DNA strand-breaking agents.
Ataxia Telangiectasia
Human topoisomerase II function, tyrosine phosphorylation and cell cycle checkpoints.
Ataxia Telangiectasia
Investigation of tRNA and ATPase 6/8 gene mutations in Iranian ataxia telangiectasia patients.
Ataxia Telangiectasia
Overproduction of topoisomerase II in an ataxia telangiectasia fibroblast cell line: comparison with a topoisomerase II-overproducing hamster cell mutant.
Ataxia Telangiectasia
Reduced DNA topoisomerase II activity in ataxia-telangiectasia cells.
Ataxia Telangiectasia
Sister chromatid exchanges and DNA topoisomerase II inhibitors: effect of low concentrations of etoposide (VP-16) in ataxia telangiectasia lymphoblastoid cell lines.
Ataxia Telangiectasia
Study of DNA topoisomerase II in ataxia-telangiectasia cells.
Ataxia Telangiectasia
Telomerase inhibition potentiates the effects of genotoxic agents in breast and colorectal cancer cells in a cell cycle-specific manner.
Atherosclerosis
Alteration of sarcoplasmic reticulum Ca(2+) ATPase expression in lower limb ischemia caused by atherosclerosis obliterans.
Atherosclerosis
Deleterious impact of elaidic fatty acid on ABCA1-mediated cholesterol efflux from mouse and human macrophages.
Atherosclerosis
Expression of sarco (endo) plasmic reticulum calcium ATPase (SERCA) system in normal mouse cardiovascular tissues, heart failure and atherosclerosis.
Atherosclerosis
Reduced lecithin: cholesterol acyltransferase (LCAT) and Na+, K+, ATPase activity in diabetic patients.
Atherosclerosis
Teniposide regulates the phenotype switching of vascular smooth muscle cells in a miR-21-dependent manner.
Atrial Fibrillation
Modulation of SERCA in Patients with Persistent Atrial Fibrillation Treated by Epicardial Thoracoscopic Ablation: The CAMAF Study.
Autoimmune Diseases
HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity.
Autoimmune Diseases
Immunopathogenesis, loss of T cell tolerance and genetics of autoimmune gastritis.
Autoimmune Diseases
Prevention of autoimmune gastritis in mice requires extra-thymic T-cell deletion and suppression by regulatory T cells.
Azotemia
An immunocytochemical study of H+ ATPase in kidney transplant rejection.
Bacteremia
Pathophysiology of acute renal failure following living Escherichia coli injection in rats: high-energy metabolism and renal functions.
Bacteremia
Pseudomonas aeruginosa bacteremia among liver transplant recipients.
Bacteremia
The pathophysiology of septic shock: acute renal failure in rats following live E coli injection. A histochemical study of the proximal tubules.
Bacterial Infections
A New-Class Antibacterial-Almost. Lessons in Drug Discovery and Development: A Critical Analysis of More than 50 Years of Effort toward ATPase Inhibitors of DNA Gyrase and Topoisomerase IV.
Bacterial Infections
Advances in DNA gyrase inhibitors.
Bacterial Infections
Chemistry, Biological Properties and Analytical Methods of Levonadifloxacin: A Review.
Bacterial Infections
Identification of an ethyl 5,6-dihydropyrazolo[1,5-c]quinazoline-1-carboxylate as a catalytic inhibitor of DNA gyrase.
Bacterial Infections
Identification of ciprofloxacin resistance by SimpleProbe, High Resolution Melt and Pyrosequencing nucleic acid analysis in biothreat agents: Bacillus anthracis, Yersinia pestis and Francisella tularensis.
Bacterial Infections
Injured mitochondria in cells of Euglena gracilis after DNA gyrase inhibitors treatment.
Bacterial Infections
Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infections.
Bacterial Infections
Olamufloxacin. Hokuriku Seiyaku.
Bacterial Infections
PD-140248 (Parke-Davis & Co).
Bacterial Infections
Repair of topoisomerase-mediated DNA damage in bacteriophage T4.
Bacterial Infections
RU-79115 (Aventis Pharma).
Bacterial Infections
Second-generation antibacterial benzimidazole ureas: discovery of a preclinical candidate with reduced metabolic liability.
Bacterial Infections
Transcriptional Suppression of the NLRP3 Inflammasome and Cytokine Release in Primary Macrophages by Low-Dose Anthracyclines.
Bardet-Biedl Syndrome
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Bartter Syndrome
Cellular potassium transport and ATPase activity in Bartter's syndrome.
Bartter Syndrome
Diseases of renal adenosine triphosphatase.
Bartter Syndrome
Erythrocyte sodium transport in Bartter's syndrome.
Blast Crisis
HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities.
Blister
Analysis of structural changes during hypotonic swelling in Ehrlich ascites tumor cells.
Blister
Biochemical mechanisms in drug-induced liver injury: certainties and doubts.
Blister
Blebbistatin: use as inhibitor of muscle contraction.
Blister
Effect of Hailey-Hailey Disease mutations on the function of a new variant of human secretory pathway Ca2+/Mn2+-ATPase (hSPCA1).
Blister
Langerhans' cells in patients with psoriasis: effect of treatment with PUVA, PUVA bath, etretinate and anthralin.
Blister
Protective effects of Ca2+ handling drugs against abnormal Ca2+ homeostasis and cell damage in myopathic skeletal muscle cells.
Blister
[Quantitative study of the number of Langerhans cells per surface unit in allergic contact eczema]
Bloom Syndrome
5-Bromodeoxyuridine-dependent increase in sister chromatid exchange formation in Bloom's syndrome is associated with reduction in topoisomerase II activity.
Bloom Syndrome
Characterization of a new BLM mutation associated with a topoisomerase II alpha defect in a patient with Bloom's syndrome.
Bloom Syndrome
DNA interactions of 2-pyrrolinodoxorubicin, a distinctively more potent daunosamine-modified analogue of doxorubicin.
Bloom Syndrome
Point mutations causing Bloom's syndrome abolish ATPase and DNA helicase activities of the BLM protein.
Bloom Syndrome
The nuclease FAN1 is involved in DNA crosslink repair in Arabidopsis thaliana independently of the nuclease MUS81.
Bone Resorption
(2Z,4E)-5-(5,6-dichloro-2-indolyl)-2-methoxy-N-(1,2,2,6,6- pentamethylpiperidin-4-yl)-2,4-pentadienamide, a novel, potent and selective inhibitor of the osteoclast V-ATPase.
Bone Resorption
Atp6v0d2 is an essential component of the osteoclast-specific proton pump that mediates extracellular acidification in bone resorption.
Bone Resorption
Bovine parathyroid hormone enhances osteoclast bone resorption by modulating V-ATPase through PTH1R.
Bone Resorption
Chronic extracellular acidosis induces plasmalemmal vacuolar type H+ ATPase activity in osteoclasts.
Bone Resorption
Fluoride decreased osteoclastic bone resorption through the inhibition of NFATc1 gene expression.
Bone Resorption
Involvement of capacitive calcium entry and calcium store refilling in osteoclastic survival and bone resorption process.
Bone Resorption
Osteoclastic acid ATPase: biochemical and histochemical studies of the osteopetrotic mutations in the rat.
Bone Resorption
Ouabain effects on hormonally-stimulated bone resorption and cyclic AMP content in cultured fetal rat bones.
Bone Resorption
Resorptive state and cell size influence intracellular pH regulation in rabbit osteoclasts cultured on collagen-hydroxyapatite films.
Bone Resorption
Selective inhibitors of the osteoclast vacuolar proton ATPase as novel bone antiresorptive agents.
Bone Resorption
Spi-C positively regulates RANKL-mediated osteoclast differentiation and function.
Bone Resorption
V-ATPase a3 isoform mutations identified in osteopetrosis patients abolish its expression and disrupt osteoclast function.
Bradycardia
Purine nucleosides stimulate Na/K ATPase, and prolong survival in hemorrhagic shock.
Brain Contusion
The effect of the treatment of high-dose methylprednisolone on Na(+)-K(+)/Mg(+2) ATPase activity and lipid peroxidation and ultrastructural findings following cerebral contusion in rat.
Brain Diseases
Isolated Hearing Impairment Caused by SPATA5 Mutations in a Family with Variable Phenotypic Expression.
Brain Diseases
Subacute necrotizing encephalopathy: oxidative phosphorylation defects and the ATPase 6 point mutation.
Brain Diseases
The aleu207-->arg mutation in F1F0-ATP synthase from Escherichia coli. A model for human mitochondrial disease.
Brain Diseases
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Brain Edema
Biochemical studies on brain swelling. I. Changes in respiratory control, 2,4-dinitrophenol induced ATPase activity and phosphorylation. Correlation between brain swelling and mitochondrial function.
Brain Edema
Enhancement of ATPase activity by a lipid peroxide of arachidonic acid in rat brain microvessels.
Brain Edema
Mechanism of action of arginine vasopressin on acute ischemic brain edema.
Brain Edema
[Biochemical study of brain edema. 3. Experiment on inhibition of Na, K-activated ATPase by ouabain in the brain]
Brain Injuries
Effect of hypothermia on brain cell membrane function and energy metabolism after transient global hypoxia-ischemia in the newborn piglet.
Brain Injuries
Neuroinflammation evoked by brain injury in a rat model of lacunar infarct.
Brain Injuries, Traumatic
Caffeine administration alters the behaviour and development of Galleria mellonella larvae.
Brain Injuries, Traumatic
Modulation of Na+/K+- ATPase activity by triterpene 3?, 6?, 16?-trihidroxilup-20 (29)-ene (TTHL) limits the long-term secondary degeneration after traumatic brain injury in mice.
Brain Ischemia
Behavioral and histologic neuroprotection of aqueous garlic extract after reversible focal cerebral ischemia.
Brain Ischemia
Effects of magnesium sulfate on Na+,K+ -ATPase and intracranial pressure level after cerebral ischemia.
Brain Ischemia
Effects of the Rabdosia rubescens total flavonoids on focal cerebral ischemia reperfusion model in rats.
Brain Ischemia
Protective effect of Nardostachys jatamansi in rat cerebral ischemia.
Brain Ischemia
The effect of 2-chloroadenosine on the ATP level Na,K ATPase activity in experimental brain ischemia of gerbil.
Brain Ischemia
The effects of 2-chloroadenosine and deoxycoformycin on the ATP level, Na-K ATPase activity in experimental brain ischemia of gerbil.
Brain Ischemia
Vacuolar protein sorting 4B regulates apoptosis of intestinal epithelial cells via p38 MAPK in Crohn's disease.
Brain Ischemia
[Effect of repeated cerebral ischemia induced by lower body negative pressure on neuronal morphology and ions contents, ATPase activity of brain tissue in rats]
Brain Ischemia
[Effects of NBP on ATPase and anti-oxidant enzymes activities and lipid peroxidation in transient focal cerebral ischemic rats]
Brain Ischemia
[Effects of salvianolic acid B on cerebral energy charge and activity of ATPase in mice with cerebral ischemia]
Brain Ischemia
[Study on regulation of tanshinone II(A) on GFAP and ATPase and PDI of cerebral ischemia reperfusion injury in rats].
Brain Neoplasms
Accelerated regression of brain metastases in patients receiving whole brain radiation and the topoisomerase II inhibitor, lucanthone.
Brain Neoplasms
ATPase in human brain tumors.
Brain Neoplasms
Convection-enhanced delivery of a topoisomerase I inhibitor (nanoliposomal topotecan) and a topoisomerase II inhibitor (pegylated liposomal doxorubicin) in intracranial brain tumor xenografts.
Brain Neoplasms
Effect of transfection of a Drosophila topoisomerase II gene into a human brain tumour cell line intrinsically resistant to etoposide.
Brain Neoplasms
Electron microscopic study of ATPase activity in human brain tumors.
Brain Neoplasms
Expression of DNA topoisomerase I, IIalpha, and IIbeta in human brain tumors.
Brain Neoplasms
Expression of topoisomerase II, bcl-2, and p53 in three human brain tumor cell lines and their possible relationship to intrinsic resistance to etoposide.
Brain Neoplasms
ICRF-187 rescue in etoposide treatment in vivo. A model targeting high-dose topoisomerase II poisons to CNS tumors.
Brain Neoplasms
Improved targeting of brain tumors using dexrazoxane rescue of topoisomerase II combined with supralethal doses of etoposide and teniposide.
Brain Neoplasms
In vivo antitumor activity of S16020, a topoisomerase II inhibitor, and doxorubicin against human brain tumor xenografts.
Brain Neoplasms
Induction of heat-shock response and alterations of protein phosphorylation by a novel topoisomerase II inhibitor, withangulatin A, in 9L rat brain tumor cells.
Brain Neoplasms
Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA.
Brain Neoplasms
Multidrug resistance protein and topoisomerase 2 alpha expression in non-small cell lung cancer are related with brain metastasis postoperatively.
Brain Neoplasms
Phosphatase activities in human glioma cells as revealed by light and electron microscopy--a preliminary study.
Brain Neoplasms
Pretreatment with the polyamine analog 1,19-bis-(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) inhibits etoposide cytotoxicity in U-251 MG (NCI) human brain tumor cells.
Brain Neoplasms
Profiles of brain metastases: Prioritization of therapeutic targets.
Brain Neoplasms
Quantitative analysis of topoisomerase IIalpha to rapidly evaluate cell proliferation in brain tumors.
Brain Neoplasms
Topoisomerase II inhibition and altered kinetics of formation and repair of nitrosourea and cisplatin-induced DNA interstrand cross-links and cytotoxicity in human glioblastoma cells.
Brain Neoplasms
Transfection of human topoisomerase II alpha into etoposide-resistant cells: transient increase in sensitivity followed by down-regulation of the endogenous gene.
Brain Neoplasms
[Difference in 201TlCl accumulation mechanism in brain tumors: a comparison of their Na(+)-K+ ATPase activities]
Brain Neoplasms
[Na+ -K+ ATPase in human brain tumors]
Brain Neoplasms
[Sensitivity to etoposide of human malignant glioma cell lines. Mechanisms of action]
Breast Neoplasms
17q12-21 - the pursuit of targeted therapy in breast cancer.
Breast Neoplasms
2,2,2-Trichloro-N-({2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin- 5-yl}carbamoyl)acetamide (UNBS3157), a novel nonhematotoxic naphthalimide derivative with potent antitumor activity.
Breast Neoplasms
A literature review of molecular markers predictive of clinical response to cytotoxic chemotherapy in patients with breast cancer.
Breast Neoplasms
A phase II study of Epirubicin in oxaliplatin-resistant patients with metastatic colorectal cancer and TOP2A gene amplification.
Breast Neoplasms
A Phase II Study of Irinotecan and Etoposide as Treatment for Refractory Metastatic Breast Cancer.
Breast Neoplasms
Aberrations of ERBB2 and TOP2A genes in breast cancer.
Breast Neoplasms
Acute myelogenous leukemia and myelodysplasia secondary to breast cancer treatment: case studies and literature review.
Breast Neoplasms
Adenovirus-mediated human topoisomerase IIalpha gene transfer increases the sensitivity of etoposide-resistant human and mouse breast cancer cells.
Breast Neoplasms
Adenovirus-mediated human topoisomerase IIalpha gene transfer increases the sensitivity of etoposide-resistant human breast cancer cells.
Breast Neoplasms
Adjusting breast cancer patient prognosis with non-HER2-gene patterns on chromosome 17.
Breast Neoplasms
Altered expression of proliferation-inducing and proliferation-inhibiting genes might contribute to acquired doxorubicin resistance in breast cancer cells.
Breast Neoplasms
Altered gene expression pattern in cultured human breast cancer cells treated with hepatocyte growth factor/scatter factor in the setting of DNA damage.
Breast Neoplasms
Amidine analogues of melphalan: synthesis, cytotoxic activity, and DNA binding properties.
Breast Neoplasms
Amplification and deletion of topoisomerase IIalpha associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer.
Breast Neoplasms
Amplification and overexpression of topoisomerase IIalpha predict response to anthracycline-based therapy in locally advanced breast cancer.
Breast Neoplasms
Amplification of growth regulatory genes in intraductal breast cancer is associated with higher nuclear grade but not with the progression to invasiveness.
Breast Neoplasms
Amplification of HER-2/neu and topoisomerase IIalpha in primary and metastatic breast cancer.
Breast Neoplasms
Amplification of HER2 and TOP2A and deletion of TOP2A genes in a series of Taiwanese breast cancer.
Breast Neoplasms
Amplification of HER2 and TOP2A and deletion of TOP2A genes in breast cancer investigated by new FISH probes.
Breast Neoplasms
Amplification of the TOP2A gene does not predict high levels of topoisomerase II alpha protein in human breast tumor samples.
Breast Neoplasms
Amplification of TOP2A and HER-2 genes in breast cancers occurring in patients harbouring BRCA1 germline mutations.
Breast Neoplasms
Analysis of ERBB2 and TOP2A gene status using fluorescence in situ hybridization versus immunohistochemistry in localized breast cancer.
Breast Neoplasms
Analysis of inhibition of topoisomerase IIalpha and cancer cell proliferation by ingenolEZ.
Breast Neoplasms
Angiotensin II suppresses adriamycin-induced apoptosis through activation of phosphatidylinositol 3-kinase/Akt signaling in human breast cancer cells.
Breast Neoplasms
Antigenic reactivity of ribosomal protein S6 and the calcium-binding ATPase inhibitor protein of mammalian mitochondria.
Breast Neoplasms
Antiproliferative activity of mammalian lignan derivatives against the human breast carcinoma cell line, ZR-75-1.
Breast Neoplasms
Antitumor activity of pyridocarbazole and benzopyridoindole derivatives that inhibit protein kinase CK2.
Breast Neoplasms
Application of Human Placental Villous Tissue Explants to Study ABC Transporter Mediated Efflux of 2,4-Dinitrophenyl-S-Glutathione.
Breast Neoplasms
Artemisinin inhibits breast cancer-induced osteolysis by inhibiting osteoclast formation and breast cancer cell proliferation.
Breast Neoplasms
Assessment of HER2 status in patients with gastroesophageal adenocarcinoma treated with epirubicin-based chemotherapy: heterogeneity-related issues and prognostic implications.
Breast Neoplasms
Assessment of Topoisomerase II ? Status in Breast Cancer by Quantitative PCR, Gene Expression Microarrays, Immunohistochemistry, and Fluorescence in Situ Hybridization.
Breast Neoplasms
Assessment of topoisomerase II-alpha gene status by dual color chromogenic
Breast Neoplasms
Association between HER2, TOP2A, and response to anthracycline-based preoperative chemotherapy in high-risk primary breast cancer.
Breast Neoplasms
Association between immunohistochemical expression of topoisomerase IIalpha, HER2 and hormone receptors and response to primary chemotherapy in breast cancer.
Breast Neoplasms
Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21.
Breast Neoplasms
Associations between clinicopathological prognostic factors and pAkt, pMAPK and topoisomerase II expression in breast cancer.
Breast Neoplasms
ATPase copper transporter A, negatively regulated by miR-148a-3p, contributes to cisplatin resistance in breast cancer cells.
Breast Neoplasms
Autoantibodies to tumor-associated antigens in breast carcinoma.
Breast Neoplasms
Berry anthocyanins and anthocyanidins exhibit distinct affinities for the efflux transporters BCRP and MDR1.
Breast Neoplasms
Breast cancer after mantle irradiation for Hodgkin's disease: correlation of clinical, pathologic, and molecular features including loss of heterozygosity at BRCA1 and BRCA2.
Breast Neoplasms
Breast cancer genes PSMC3IP and EPSTI1 play a role in apoptosis regulation.
Breast Neoplasms
c-erbB2 and topoisomerase IIalpha protein expression independently predict poor survival in primary human breast cancer: a retrospective study.
Breast Neoplasms
Cancer cell adaptation to chemotherapy.
Breast Neoplasms
Candidate biomarkers predictive of anthracycline and taxane efficacy against breast cancer.
Breast Neoplasms
Carbonic anhydrase IX is a predictive marker of doxorubicin resistance in early-stage breast cancer independent of HER2 and TOP2A amplification.
Breast Neoplasms
Cardiac Glycoside Activities Link Na(+)/K(+) ATPase Ion-Transport to Breast Cancer Cell Migration via Correlative SAR.
Breast Neoplasms
CEF is superior to CMF for tumours with TOP2A aberrations: a Subpopulation Treatment Effect Pattern Plot (STEPP) analysis on Danish Breast Cancer Cooperative Group Study 89D.
Breast Neoplasms
Changes of Topoisomerase II{alpha} Expression in Breast Tumors after Neoadjuvant Chemotherapy Predicts Relapse-Free Survival.
Breast Neoplasms
Characterization of therapy-related acute leukemia in hereditary breast-ovarian carcinoma patients: role of BRCA1 mutation and topoisomerase II-directed therapy.
Breast Neoplasms
Characterization of topoisomerase II alpha gene amplification and deletion in breast cancer.
Breast Neoplasms
Chromosome 17 centromere duplication and responsiveness to anthracycline-based neoadjuvant chemotherapy in breast cancer.
Breast Neoplasms
Clinical analysis of 21-gene recurrence score test in hormone receptor-positive early-stage breast cancer.
Breast Neoplasms
Clinical evaluation of developed PCR-based method with hydrolysis probes for TOP2A copy number evaluation in breast cancer samples.
Breast Neoplasms
Clinical significance of the increased multidrug resistance-associated protein (MRP) gene expression in patients with primary breast cancer.
Breast Neoplasms
Clinical significance of topoisomerase 2A expression and gene change in operable invasive breast cancer.
Breast Neoplasms
Clinicopathological and prognostic significance of vascular endothelial growth factors (VEGF)-C and -D and VEGF receptor 3 in invasive breast carcinoma.
Breast Neoplasms
Clinicopathological Significance of the Proliferation Markers Ki67, RacGAP1, and Topoisomerase 2 Alpha in Breast Cancer.
Breast Neoplasms
Co-amplification of erbB2, topoisomerase II alpha and retinoic acid receptor alpha genes in breast cancer and allelic loss at topoisomerase I on chromosome 20.
Breast Neoplasms
Combinatorial therapy for triple negative breast cancer using hyperstar polymer-based nanoparticles.
Breast Neoplasms
Comparative analysis of xanafide cytotoxicity in breast cancer cell lines.
Breast Neoplasms
Comparative value of tumour grade, hormonal receptors, Ki-67, HER-2 and topoisomerase II alpha status as predictive markers in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy.
Breast Neoplasms
Comparison of immunohistochemical and fluorescence in situ hybridization assessment for HER-2/neu status in Taiwanese breast cancer patients.
Breast Neoplasms
Comparison of topoisomerase-IIalpha gene status between primary breast cancer and corresponding distant metastatic sites.
Breast Neoplasms
Copy number analysis of c-erb-B2 (HER-2/neu) and topoisomerase IIalpha genes in breast carcinoma by quantitative real-time polymerase chain reaction using hybridization probes and fluorescence in situ hybridization.
Breast Neoplasms
Correlation between DNA topoisomerase II activity and cytotoxicity in pMC540 and merodantoin sensitive and resistant human breast cancer cells.
Breast Neoplasms
Correlation between ER, PR, HER-2, Bcl-2, p53, proliferative and apoptotic indexes with HER-2 gene amplification and TOP2A gene amplification and deletion in four molecular subtypes of breast cancer.
Breast Neoplasms
Correlation between p53, c-erbB-2, and topoisomerase II alpha expression, DNA ploidy, hormonal receptor status and proliferation in 356 node-negative breast carcinomas: prognostic implications.
Breast Neoplasms
Correlations of TOP2A gene aberrations and expression of topoisomerase II? protein and TOP2A mRNA expression in primary breast cancer: a retrospective study of 86 cases using fluorescence in situ hybridization and immunohistochemistry.
Breast Neoplasms
Curcumin reverses doxorubicin resistance via inhibition the efflux function of ABCB4 in doxorubicin?resistant breast cancer cells.
Breast Neoplasms
Cytotoxicity of a Natural Anthraquinone (Aloin) Against Human Breast Cancer Cell Lines with and without ErbB-2: Topoisomerase IIalpha Coamplification.
Breast Neoplasms
DCZ3112, a novel Hsp90 inhibitor, exerts potent antitumor activity against HER2-positive breast cancer through disruption of Hsp90-Cdc37 interaction.
Breast Neoplasms
Decreased DNA topoisomerase II alpha expression and cold-sensitive growth in a mouse mammary cancer cell line resistant to etoposide and doxorubicin.
Breast Neoplasms
Design, synthesis, and evaluation of a radicicol and geldanamycin chimera, radamide.
Breast Neoplasms
Detection of gene amplification in archival breast cancer specimens by laser-assisted microdissection and quantitative real-time polymerase chain reaction.
Breast Neoplasms
Differential engagement of ORAI1 and TRPC1 in the induction of vimentin expression by different stimuli.
Breast Neoplasms
Differential expression of the topoisomerase II alpha and beta genes in human breast cancers.
Breast Neoplasms
Discovery and Biological Evaluations of Halogenated 2,4-Diphenyl Indeno[1,2-b]pyridinol Derivatives as Potent Topoisomerase II?-Targeted Chemotherapeutic Agents for Breast Cancer.
Breast Neoplasms
Disruption of nucleocytoplasmic trafficking of cyclin D1 and topoisomerase II by sanguinarine.
Breast Neoplasms
DNA damage, c-myc suppression and apoptosis induced by the novel topoisomerase II inhibitor, salvicine, in human breast cancer MCF-7 cells.
Breast Neoplasms
DNA topoisomerase II-alpha immunoreactivity as a marker of tumor aggressiveness in invasive breast cancer.
Breast Neoplasms
DNA topoisomerase IIalpha (TOP2A) inhibitors up-regulate fatty acid synthase gene expression in SK-Br3 breast cancer cells: in vitro evidence for a 'functional amplicon' involving FAS, Her-2/neu and TOP2A genes.
Breast Neoplasms
DNA topoisomerase IIalpha expression and the response toprimary chemotherapy in breast cancer.
Breast Neoplasms
Down-regulation of human topoisomerase IIalpha expression correlates with relative amounts of specificity factors Sp1 and Sp3 bound at proximal and distal promoter regions.
Breast Neoplasms
Dual-colour CISH is a reliable alternative to FISH for assessment of topoisomerase 2-alpha amplification in breast carcinomas.
Breast Neoplasms
Effect of the different phosphorylated Smad2 protein localizations on the invasive breast carcinoma phenotype.
Breast Neoplasms
Enhanced drug internalization and therapeutic efficacy of PEGylated nanoparticles by one-step formulation with anti-mPEG bispecific antibody in intrinsic drug-resistant breast cancer.
Breast Neoplasms
Enhanced etoposide sensitivity following adenovirus-mediated human topoisomerase IIalpha gene transfer is independent of topoisomerase IIbeta.
Breast Neoplasms
ER, HER2, and TOP2A expression in primary tumor, synchronous axillary nodes, and asynchronous metastases in breast cancer.
Breast Neoplasms
ERBB2 and TOP2A in breast cancer: a comprehensive analysis of gene amplification, RNA levels, and protein expression and their influence on prognosis and prediction.
Breast Neoplasms
ERK1/2 signaling plays an important role in topoisomerase II poison-induced G2/M checkpoint activation.
Breast Neoplasms
Estrogen-induced potentiation of DNA damage and cytotoxicity in human breast cancer cells treated with topoisomerase II-interactive antitumor drugs.
Breast Neoplasms
Evaluation of drug efflux transporter liabilities of darifenacin in cell culture models of the blood-brain and blood-ocular barriers.
Breast Neoplasms
Evaluation of the predictive value of topoisomerase II alpha in patients with breast carcinoma.
Breast Neoplasms
Evaluation of the prognostic role of centromere 17 gain and HER2/topoisomerase II alpha gene status and protein expression in patients with breast cancer treated with anthracycline-containing adjuvant chemotherapy: pooled analysis of two Hellenic Cooperative Oncology Group (HeCOG) phase III trials.
Breast Neoplasms
Evidence for association of SNPs in ABCB1 and CBR3, but not RAC2, NCF4, SLC28A3 or TOP2B, with chronic cardiotoxicity in a cohort of breast cancer patients treated with anthracyclines.
Breast Neoplasms
Expression analysis of TOP2A, MSH2 and MLH1 genes in MCF7 cells at different levels of etoposide resistance.
Breast Neoplasms
Expression of M2 macrophage markers YKL-39 and CCL18 in breast cancer is associated with the effect of neoadjuvant chemotherapy.
Breast Neoplasms
Expression of the vascular endothelial growth factor receptor-2/Flk-1 in breast carcinomas: correlation with proliferation.
Breast Neoplasms
Expression of tissue inhibitor of matrix metalloproteinases (TIMP)-3 protein in invasive breast carcinoma: relation to tumor phenotype and clinical outcome.
Breast Neoplasms
Expression of topoisomerase IIalpha is associated with rapid cell proliferation, aneuploidy, and c-erbB2 overexpression in breast cancer.
Breast Neoplasms
Extensive analysis of the molecular biomarkers excision repair cross complementing 1, ribonucleotide reductase M1, ?-tubulin III, thymidylate synthetase, and topoisomerase II? in breast cancer: Association with clinicopathological characteristics.
Breast Neoplasms
Extra copies of chromosomes 16 and X in invasive breast carcinomas are related to aggressive phenotype and poor prognosis.
Breast Neoplasms
FISH Analysis of TOP2A and HER-2 Aberrations in Female Breast Carcinoma on Archived Material: Egyptian NCI Experience.
Breast Neoplasms
Functional transcriptomic annotation and protein-protein interaction network analysis identify NEK2, BIRC5, and TOP2A as potential targets in obese patients with luminal A breast cancer.
Breast Neoplasms
Gene copy mapping of the ERBB2/TOP2A region in breast cancer.
Breast Neoplasms
Gene expression and pathologic response to neoadjuvant chemotherapy in breast cancer.
Breast Neoplasms
Gene expression of topoisomerase II alpha (TOP2A) by microarray analysis is highly prognostic in estrogen receptor (ER) positive breast cancer.
Breast Neoplasms
Gene expression profiling of breast cancer patients treated with docetaxel, doxorubicin, and cyclophosphamide within the GEPARTRIO trial: HER-2, but not topoisomerase II alpha and microtubule-associated protein tau, is highly predictive of tumor response.
Breast Neoplasms
Genome-wide ChIP-seq analysis of human TOP2B occupancy in MCF7 breast cancer epithelial cells.
Breast Neoplasms
Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines.
Breast Neoplasms
Growth arrest and cell death in the breast tumor cell in response to ionizing radiation and chemotherapeutic agents which induce DNA damage.
Breast Neoplasms
Growth factor signalling in clinical breast cancer and its impact on response to conventional therapies: a review of chemotherapy.
Breast Neoplasms
Heat shock cognate 70 mutations in sporadic breast carcinoma.
Breast Neoplasms
Hepatocyte growth factor/scatter factor blocks the mitochondrial pathway of apoptosis signaling in breast cancer cells.
Breast Neoplasms
HER-2 amplification and topoisomerase IIalpha gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil.
Breast Neoplasms
HER-2 and TOP2A coamplification in urinary bladder cancer.
Breast Neoplasms
HER-2, TOP2A and Chromosome 17 Alterations in Breast Cancer.
Breast Neoplasms
HER-2/neu and topoisomerase IIa gene amplification and protein expression in invasive breast carcinomas: chromogenic in situ hybridization and immunohistochemical analyses.
Breast Neoplasms
HER-2/neu and topoisomerase IIalpha in breast cancer.
Breast Neoplasms
HER-2/neu and topoisomerase IIalpha--simultaneous drug targets in cancer.
Breast Neoplasms
HER-2/neu as a predictive marker in a population of advanced breast cancer patients randomly treated either with single-agent doxorubicin or single-agent docetaxel.
Breast Neoplasms
HER2 and TOP2A amplification in a hospital-based cohort of breast cancer patients: associations with patient and tumor characteristics.
Breast Neoplasms
HER2 and TOP2A as predictive markers for anthracycline-containing chemotherapy regimens as adjuvant treatment of breast cancer: a meta-analysis of individual patient data.
Breast Neoplasms
HER2 and TOP2A in high-risk early breast cancer patients treated with adjuvant epirubicin-based dose-dense sequential chemotherapy.
Breast Neoplasms
HER2 and topoisomerase IIalpha: possible predictors of response to neoadjuvant chemotherapy for breast cancer patients.
Breast Neoplasms
HER2, TOP2A, and TIMP-1 and responsiveness to adjuvant anthracycline-containing chemotherapy in high-risk breast cancer patients.
Breast Neoplasms
Heregulin induces expression, ATPase activity, and nuclear localization of G3BP, a Ras signaling component, in human breast tumors.
Breast Neoplasms
High mobility group A2 potentiates genotoxic stress in part through the modulation of basal and DNA damage-dependent phosphatidylinositol 3-kinase-related protein kinase activation.
Breast Neoplasms
High-resolution genomic and expression analyses of copy number alterations in HER2-amplified breast cancer.
Breast Neoplasms
Human DNA topoisomerase II-alpha: a new marker of cell proliferation in invasive breast cancer.
Breast Neoplasms
ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression.
Breast Neoplasms
Identification of novel topoisomerase II alpha inhibitors by virtual screening, molecular docking, and bioassay.
Breast Neoplasms
Identification of Potential Crucial Genes and Key Pathways in Breast Cancer Using Bioinformatic Analysis.
Breast Neoplasms
Immunocytochemical detection of DNA topoisomerase type II in primary breast carcinomas: correlation with clinico-pathological features.
Breast Neoplasms
Immunohistochemical detection of P glycoprotein, glutathione S transferase and DNA topoisomerase II in human tumors.
Breast Neoplasms
Immunohistochemical study of topoisomerase II-alpha expression in primary ductal carcinoma of the breast.
Breast Neoplasms
In vivo synergy between topoisomerase II and histone deacetylase inhibitors: predictive correlates.
Breast Neoplasms
Increase therapy-related leukemia secondary to breast cancer.
Breast Neoplasms
Increased Expression of c-Met is Associated with Chemotherapy-Resistant Breast Cancer and Poor Clinical Outcome.
Breast Neoplasms
Increasing oxidative damage and loss of mismatch repair enzymes during breast carcinogenesis.
Breast Neoplasms
Individualized chemotherapy guided by the expression of ERCC1, RRM1, TUBB3, TYMS and TOP2A genes versus classic chemotherapy in the treatment of breast cancer: A comparative effectiveness study.
Breast Neoplasms
Induction of DNA damage, inhibition of DNA synthesis and suppression of c-myc expression by the anthracycline analog, idarubicin (4-demethoxy-daunorubicin) in the MCF-7 breast tumor cell line.
Breast Neoplasms
Induction of DNA damage, inhibition of DNA synthesis, and suppression of c-myc expression by the topoisomerase I inhibitor, camptothecin, in MCF-7 human breast tumor cells.
Breast Neoplasms
Induction of topoisomerase II activity after ErbB2 activation is associated with a differential response to breast cancer chemotherapy.
Breast Neoplasms
Influence of amsacrine (m-AMSA) on bulk and gene-specific DNA damage and c-myc expression in MCF-7 breast tumor cells.
Breast Neoplasms
Influence of hepatic and intestinal efflux transporters and their genetic variants on the pharmacokinetics and pharmacodynamics of raloxifene in osteoporosis treatment.
Breast Neoplasms
Influence of topoisomerase II inhibitors and ionizing radiation on growth arrest and cell death pathways in the breast tumor cell.
Breast Neoplasms
Inhibition of human MDR1 and BCRP transporter ATPase activity by organochlorine and pyrethroid insecticides.
Breast Neoplasms
Inhibition of vacuolar H+ ATPase enhances sensitivity to tamoxifen via up-regulation of CHOP in breast cancer cells.
Breast Neoplasms
Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers.
Breast Neoplasms
Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells.
Breast Neoplasms
Interphase cytogenetic analysis of erbB2 and topoII alpha co-amplification in invasive breast cancer and polysomy of chromosome 17 in ductal carcinoma in situ.
Breast Neoplasms
Intratumoral heterogeneity of HER2/neu and topoisomerase IIalpha in breast cancer: a case with clonal monosomy 17.
Breast Neoplasms
Ionizing radiation and teniposide increase p21(waf1/cip1) and promote Rb dephosphorylation but fail to suppress E2F activity in MCF-7 breast tumor cells.
Breast Neoplasms
Isolated tumor cells in the bone marrow (ITC-BM) of breast cancer patients before and after anthracyclin based therapy: influenced by the HER2- and Topoisomerase IIalpha-status of the primary tumor?
Breast Neoplasms
Knockdown of PSMC3IP suppresses the proliferation and xenografted tumorigenesis of hepatocellular carcinoma cell.
Breast Neoplasms
Lack of independent prognostic and predictive value of centromere 17 copy number changes in breast cancer patients with known HER2 and TOP2A status.
Breast Neoplasms
Lack of prognostic value of topoisomerase II alpha in patients with breast cancer: analysis with tissue microarray.
Breast Neoplasms
Leukemia risk after adjuvant treatment of early breast cancer.
Breast Neoplasms
Loss of protein kinase C?/HuR interaction is necessary to doxorubicin resistance in breast cancer cell lines.
Breast Neoplasms
Marked intratumoral heterogeneity of c-myc and cyclinD1 but not of c-erbB2 amplification in breast cancer.
Breast Neoplasms
Markers for Sebaceoma Show a Spectrum of Cell Cycle Regulators, Tumor Suppressor Genes, and Oncogenes.
Breast Neoplasms
Metnase mediates resistance to topoisomerase II inhibitors in breast cancer cells.
Breast Neoplasms
MGMT inhibition in ER positive breast cancer leads to CDC2, TOP2A, AURKB, CDC20, KIF20A, Cyclin A2, Cyclin B2, Cyclin D1, ER? and Survivin inhibition and enhances response to temozolomide.
Breast Neoplasms
MicroRNA-139 suppresses proliferation in luminal type breast cancer cells by targeting Topoisomerase II alpha.
Breast Neoplasms
Mitochondrial complex I and V gene polymorphisms associated with breast cancer in mizo-mongloid population.
Breast Neoplasms
Mitogen-induced topoisomerase II synthesis precedes DNA synthesis in human breast cancer cells.
Breast Neoplasms
Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines.
Breast Neoplasms
Molecular cytogenetic evaluation of the efficacy of photodynamic therapy by indocyanine green in breast adenocarcinoma MCF-7 cells.
Breast Neoplasms
Molecular docking, synthesis and anticancer activity of thiosemicarbazone derivatives against MCF-7 human breast cancer cell line.
Breast Neoplasms
Molecular subtypes of breast cancer and amplification of topoisomerase II alpha: predictive role in dose intensive adjuvant chemotherapy.
Breast Neoplasms
Multidrug resistance-associated protein gene overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide resistance.
Breast Neoplasms
Multiplication of Chromosome 17 Centromere Is Associated with Prognosis in Patients with Invasive Breast Cancers Exhibiting Normal HER2 and TOP2A Status.
Breast Neoplasms
Mutant Bik expression mediated by the enhanced minimal topoisomerase IIalpha promoter selectively suppressed breast tumors in an animal model.
Breast Neoplasms
New understanding of the role of anthracyclines in early-stage breast cancer: patient selection considerations.
Breast Neoplasms
Newly Synthesized Imino-Derivatives Analogues of Resveratrol Exert Inhibitory Effects in Breast Tumor Cells.
Breast Neoplasms
Nitric oxide inhibits ATPase activity and induces resistance to topoisomerase II-poisons in human MCF-7 breast tumor cells.
Breast Neoplasms
Novel molecular markers of malignancy in histologically normal and benign breast.
Breast Neoplasms
Obg-Like ATPase 1 Enhances Chemoresistance of Breast Cancer via Activation of TGF-?/Smad Axis Cascades.
Breast Neoplasms
Oestrogen potentiates topoisomerase-II-mediated cytotoxicity in an activated subpopulation of human breast cancer cells: implications for cytotoxic drug resistance in solid tumours.
Breast Neoplasms
Outcome of patients with early-stage breast cancer treated with doxorubicin-based adjuvant chemotherapy as a function of HER2 and TOP2A status.
Breast Neoplasms
Overexpression of cyclooxygenase-2 is associated with a favorable prognostic phenotype in breast carcinoma.
Breast Neoplasms
Overexpression of the ATPase Inhibitory Factor 1 Favors a Non-metastatic Phenotype in Breast Cancer.
Breast Neoplasms
Overexpression of topoisomerase II alpha protein is a factor for poor prognosis in patients with luminal B breast cancer.
Breast Neoplasms
PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells.
Breast Neoplasms
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Breast Neoplasms
Pharmacokinetic study of cisplatin and infusional etoposide phosphate in advanced breast cancer with correlation of response to topoisomerase IIalpha expression.
Breast Neoplasms
Phenotypic and genetic characterization of circulating tumor cells by combining immunomagnetic selection and FICTION techniques.
Breast Neoplasms
Phosphorylation and stabilization of topoisomerase II? protein by p38? mitogen-activated protein kinase sensitize breast cancer cells to its poisons.
Breast Neoplasms
Positive response to neoadjuvant cyclophosphamide and doxorubicin in topoisomerase II nonamplified/HER2/neu negative/polysomy 17 absent breast cancer patients.
Breast Neoplasms
Predictive value of apoptosis, proliferation, HER-2, and topoisomerase IIalpha for anthracycline chemotherapy in locally advanced breast cancer.
Breast Neoplasms
Predictive value of HER-2 and Topoisomerase IIalpha in response to primary doxorubicin in breast cancer.
Breast Neoplasms
Predictive value of topoisomerase IIalpha and other prognostic factors for epirubicin chemotherapy in advanced breast cancer.
Breast Neoplasms
Prognoses and genomic analyses of proteasome 26S subunit, ATPase (PSMC) family genes in clinical breast cancer.
Breast Neoplasms
Prognostic and predictive value of the combination of TOP2A and HER2 in node-negative tumors 2 cm or smaller (T1N0) breast cancer.
Breast Neoplasms
Prognostic relevance of disseminated tumor cells in the bone marrow and biological factors of 265 primary breast carcinomas.
Breast Neoplasms
Prognostic significance of Ki-67 and topoisomerase IIalpha expression in infiltrating ductal carcinoma of the breast. A multivariate analysis of 863 cases.
Breast Neoplasms
Prognostic Significance of TOP2A Gene Dosage in HER-2-Negative Breast Cancer.
Breast Neoplasms
Prognostic Value of TOP2A Gene Amplification and Chromosome 17 Polysomy in Early Breast Cancer.
Breast Neoplasms
Prognostic value of Topoisomerase II in female breast cancer.
Breast Neoplasms
Proliferation and invasion of colon cancer cells are suppressed by knockdown of TOP2A.
Breast Neoplasms
Proteomic analysis of infiltrating ductal carcinoma tissues by coupled 2-D DIGE/MS/MS analysis.
Breast Neoplasms
Quantification and clinical relevance of gene amplification at chromosome 17q12-q21 in human epidermal growth factor receptor 2-amplified breast cancers.
Breast Neoplasms
Quantitative transporter proteomics by liquid chromatography with tandem mass spectrometry: addressing methodologic issues of plasma membrane isolation and expression-activity relationship.
Breast Neoplasms
Quantum dot-based immunofluorescent imaging and quantitative detection of TOP2A and prognostic value in triple-negative breast cancer.
Breast Neoplasms
Re: Topoisomerase II alpha and responsiveness of breast cancer to adjuvant chemotherapy.
Breast Neoplasms
Rearrangements of the MLL gene are influenced by DNA secondary structure, potentially mediated by topoisomerase II binding.
Breast Neoplasms
Reduced DNA topoisomerase II in VP-16 resistant mouse breast cancer cell line.
Breast Neoplasms
Relationship between expression of topoisomerase II isoforms and intrinsic sensitivity to topoisomerase II inhibitors in breast cancer cell lines.
Breast Neoplasms
Relationship between Topoisomerase 2A RNA Expression and Recurrence after Adjuvant Chemotherapy for Breast Cancer.
Breast Neoplasms
Resistance to topoisomerase II inhibitors in human glioma cell lines overexpressing multidrug resistant associated protein (MRP) 2.
Breast Neoplasms
retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group.
Breast Neoplasms
RRM1, TUBB3, TOP2A, CYP19A1, CYP2D6: Difference between mRNA and protein expression in predicting prognosis of breast cancer patients.
Breast Neoplasms
RUVBL1-ITFG1 interaction is required for collective invasion in breast cancer.
Breast Neoplasms
Second malignancies following adjuvant chemotherapy: 6-year results from a Belgian randomized study comparing cyclophosphamide, methotrexate and 5-fluorouracil (CMF) with an anthracycline-based regimen in adjuvant treatment of node-positive breast cancer patients.
Breast Neoplasms
Sequence-specific potentiation of topoisomerase II inhibitors by the histone deacetylase inhibitor suberoylanilide hydroxamic acid.
Breast Neoplasms
Serial topoisomerase II expression in primary breast cancer and response to neoadjuvant anthracycline-based chemotherapy.
Breast Neoplasms
Sharp Downregulation of Hub Genes Associated With the Pathogenesis of Breast Cancer From Ductal Carcinoma In Situ to Invasive Ductal Carcinoma.
Breast Neoplasms
Short-term expansion of breast circulating cancer cells predicts response to anti-cancer therapy.
Breast Neoplasms
Significant prognostic values of differentially expressed-aberrantly methylated hub genes in breast cancer.
Breast Neoplasms
Simultaneous amplification of HER-2 (ERBB2) and topoisomerase IIalpha (TOP2A) genes--molecular basis for combination chemotherapy in cancer.
Breast Neoplasms
Simultaneous detection of TOP2A and HER2 gene amplification by multiplex ligation-dependent probe amplification in breast cancer.
Breast Neoplasms
Sodium/potasium ATPase (Na(+), K(+)-ATPase) and ouabain/related cardiac glycosides: a new paradigm for development of anti- breast cancer drugs?
Breast Neoplasms
Solamargine induces apoptosis and enhances susceptibility to trastuzumab and epirubicin in breast cancer cells with low or high expression levels of HER2/neu.
Breast Neoplasms
Statistical modeling for selecting housekeeper genes.
Breast Neoplasms
Stromelysin-3 protein expression in invasive breast cancer: relation to proliferation, cell survival and patients' outcome.
Breast Neoplasms
Structure/activity Relationship of Thapsigargin Inhibition on the Purified Golgi/secretory Pathway Ca2+/Mn2+ Transport ATPase (SPCA1a).
Breast Neoplasms
Study of molecular markers of resistance to m-AMSA in a human breast cancer cell line. Decrease of topoisomerase II and increase of both topoisomerase I and acidic glutathione S transferase.
Breast Neoplasms
Study of the topographic distribution of ets-1 protein expression in invasive breast carcinomas in relation to tumor phenotype.
Breast Neoplasms
Suppression of c-myc expression and c-Myc function in response to sustained DNA damage in MCF-7 breast tumor cells.
Breast Neoplasms
Suppression of PTEN/AKT signaling decreases the expression of TUBB3 and TOP2A with subsequent inhibition of cell growth and induction of apoptosis in human breast cancer MCF-7 cells via ATP and caspase-3 signaling pathways.
Breast Neoplasms
SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.
Breast Neoplasms
Synthesis and biological activity of thiazolylindolequinones, analogues of the natural product BE 10988.
Breast Neoplasms
Targeting the chromatin remodeling enzyme BRG1 increases the efficacy of chemotherapy drugs in breast cancer cells.
Breast Neoplasms
Thapsigargin, Inhibitor of Sarco-Endoplasmic Ca2+-ATPase, Effectively Suppresses the Expression of S100A4 Protein in Human Breast Cancer Cell Line.
Breast Neoplasms
The ascidian natural product eusynstyelamide B is a novel topoisomerase II poison that induces DNA damage and growth arrest in prostate and breast cancer cells.
Breast Neoplasms
The binding proximity of methyl ?-lilacinobioside isolated from Caralluma retrospiciens with topoisomerase II attributes apoptosis in breast cancer cell line.
Breast Neoplasms
The design, synthesis, and evaluation of coumarin ring derivatives of the novobiocin scaffold that exhibit antiproliferative activity.
Breast Neoplasms
The effect of eIF3a on anthracycline-based chemotherapy resistance by regulating DSB DNA repair.
Breast Neoplasms
The favourable prognostic value of oestrogen receptor beta immunohistochemical expression in breast cancer.
Breast Neoplasms
The Golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like growth factor receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231.
Breast Neoplasms
The HER2 amplicon in breast cancer: Topoisomerase IIA and beyond.
Breast Neoplasms
The incidence of topoisomerase II-alpha genomic alterations in adenocarcinoma of the breast and their relationship to human epidermal growth factor receptor-2 gene amplification: a fluorescence in situ hybridization study.
Breast Neoplasms
The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomerase IIalpha in breast cancer cells.
Breast Neoplasms
The novel alkylating prodrug J1: diagnosis directed activity profile ex vivo and combination analyses in vitro.
Breast Neoplasms
The prognostic significance of topoisomerase II alpha protein in early stage luminal breast cancer.
Breast Neoplasms
The role of topoisomerase IIalpha and HER-2 in predicting sensitivity to anthracyclines in breast cancer patients.
Breast Neoplasms
The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation.
Breast Neoplasms
The topoisomerase II alpha gene status in primary breast cancer is a predictive marker of the response to anthracycline-based neoadjuvant chemotherapy.
Breast Neoplasms
The ubiquitin-conjugating enzyme E2-EPF is overexpressed in primary breast cancer and modulates sensitivity to topoisomerase II inhibition.
Breast Neoplasms
The value of TOP2A gene copy number variation as a biomarker in breast cancer: Update of DBCG trial 89D.
Breast Neoplasms
The value of TOP2A, EZH2 and paxillin expression as markers of aggressive breast cancer: relationship with other prognostic factors.
Breast Neoplasms
The vitamin D3 analog EB 1089 enhances the response of human breast tumor cells to radiation.
Breast Neoplasms
Therapeutic strategies in male breast cancer: Clinical implications of chromosome 17 gene alterations and molecular subtypes.
Breast Neoplasms
Therapy-related acute lymphoblastic leukaemia with MLL rearrangements following DNA topoisomerase II inhibitors, an increasing problem: report on two new cases and review of the literature since 1992.
Breast Neoplasms
Therapy-related acute promyelocytic leukemia: a systematic review.
Breast Neoplasms
TIMP-1 in combination with HER2 and TOP2A for prediction of benefit from adjuvant anthracyclines in high-risk breast cancer patients.
Breast Neoplasms
Tissue-specific selection of optimal reference genes for expression analysis of anti-cancer drug-related genes in tumor samples using quantitative real-time RT-PCR.
Breast Neoplasms
TOP2A Amplification in Breast Cancer in the Absence of that of HER-2: Myth or Reality?
Breast Neoplasms
TOP2A amplification in breast cancer is a predictive marker of anthracycline-based neoadjuvant chemotherapy efficacy.
Breast Neoplasms
TOP2A Amplification in the Absence of That of HER-2/neu: Toward Individualization of Chemotherapeutic Practice in Breast Cancer.
Breast Neoplasms
TOP2A and HER-2 gene amplification in fine needle aspirates from breast carcinomas.
Breast Neoplasms
TOP2A and HER2 gene amplification as predictors of response to anthracycline treatment in breast cancer.
Breast Neoplasms
TOP2A gene copy number change in breast cancer.
Breast Neoplasms
TOP2A overexpression as a poor prognostic factor in patients with nasopharyngeal carcinoma.
Breast Neoplasms
TOP2A protein by quantitative immunofluorescence as a predictor of response to epirubicin in the neoadjuvant treatment of breast cancer.
Breast Neoplasms
TOP2A RNA expression and recurrence in estrogen receptor-positive breast cancer.
Breast Neoplasms
Topoisomerase 2 alpha and the case for individualized breast cancer therapy.
Breast Neoplasms
Topoisomerase 2 alpha: a real predictor of anthracycline efficacy?
Breast Neoplasms
Topoisomerase I and II activity in human breast, cervix, lung and colon cancer.
Breast Neoplasms
Topoisomerase II ? Gene alteration in Triple Negative Breast Cancer and Its Predictive Role for Anthracycline-Based Chemotherapy (Egyptian NCI Patients)
Breast Neoplasms
Topoisomerase II alpha amplification may predict benefit from adjuvant anthracyclines in HER2 positive early breast cancer.
Breast Neoplasms
Topoisomerase II alpha and microtubule-associated protein-tau as a predictive marker in axillary lymph node positive breast cancer.
Breast Neoplasms
Topoisomerase II alpha and responsiveness of breast cancer to adjuvant chemotherapy.
Breast Neoplasms
Topoisomerase II alpha and TLE3 as predictive markers of response to anthracycline and taxane-containing regimens for neoadjuvant chemotherapy in breast cancer.
Breast Neoplasms
Topoisomerase II alpha as a marker predicting anthracyclines' activity in early breast cancer patients: ready for the primetime?
Breast Neoplasms
Topoisomerase II alpha as a marker predicting the efficacy of anthracyclines in breast cancer: are we at the end of the beginning?
Breast Neoplasms
Topoisomerase II alpha co-amplification with erbB2 in human primary breast cancer and breast cancer cell lines: relationship to m-AMSA and mitoxantrone sensitivity.
Breast Neoplasms
Topoisomerase II alpha expression and the Ki-67 labeling index correlate with prognostic factors in estrogen receptor-positive and human epidermal growth factor type-2-negative breast cancer.
Breast Neoplasms
Topoisomerase II alpha expression correlates with diminished disease-free survival in invasive breast cancer.
Breast Neoplasms
Topoisomerase II alpha expression in breast ductal invasive carcinomas and correlation with clinicopathological variables.
Breast Neoplasms
Topoisomerase II alpha gene amplification is a favorable prognostic factor in patients with HER2-positive metastatic breast cancer treated with trastuzumab.
Breast Neoplasms
Topoisomerase II alpha gene copy loss has adverse prognostic significance in ERBB2-amplified breast cancer: a retrospective study of paraffin-embedded tumor specimens and medical charts.
Breast Neoplasms
Topoisomerase II alpha protein and responsiveness of breast cancer to adjuvant chemotherapy with CEF compared to CMF in the NCIC CTG randomized MA.5 adjuvant trial.
Breast Neoplasms
Topoisomerase II alpha--a fundamental prognostic factor in breast carcinoma.
Breast Neoplasms
Topoisomerase II-alfa gene as a predictive marker of response to anthracyclines in breast cancer.
Breast Neoplasms
Topoisomerase II-alpha (topoII) and HER2 amplification in breast cancers and response to preoperative doxorubicin chemotherapy.
Breast Neoplasms
Topoisomerase II-alpha gene deletion is not frequent as its amplification in breast cancer.
Breast Neoplasms
Topoisomerase II-mediated DNA cleavage activity induced by ellipticines on the human tumor cell line N417.
Breast Neoplasms
Topoisomerase IIalpha and APE/ref-1 are associated with pathologic response to primary anthracycline-based chemotherapy for breast cancer.
Breast Neoplasms
Topoisomerase IIalpha expression in breast cancer: correlation with outcome variables.
Breast Neoplasms
Topoisomerase IIalpha expression rather than gene amplification predicts responsiveness of adjuvant anthracycline-based chemotherapy in women with primary breast cancer.
Breast Neoplasms
Topoisomerase IIalpha gene (TOP2A) amplification and deletion in cancer--more common than anticipated.
Breast Neoplasms
Topoisomerase IIalpha gene amplification and response to anthracycline-containing adjuvant chemotherapy in breast cancer.
Breast Neoplasms
Topoisomerase IIalpha gene amplification predicts favorable treatment response to tailored and dose-escalated anthracycline-based adjuvant chemotherapy in HER-2/neu-amplified breast cancer: Scandinavian Breast Group Trial 9401.
Breast Neoplasms
Topoisomerase IIalpha gene status and prediction of pathological complete remission after anthracycline-based neoadjuvant chemotherapy in endocrine non-responsive Her2/neu-positive breast cancer.
Breast Neoplasms
Topoisomerase II{alpha} amplification does not predict benefit from dose-intense cyclophosphamide, doxorubicin, and fluorouracil therapy in HER2-amplified early breast cancer: results of CALGB 8541/150013.
Breast Neoplasms
Topoisomerase-II alpha expression as a predictive marker in a population of advanced breast cancer patients randomly treated either with single-agent doxorubicin or single-agent docetaxel.
Breast Neoplasms
Transcriptional down-regulation of c-myc expression in the MCF-7 breast tumor cell line by the topoisomerase II inhibitor, VM-26.
Breast Neoplasms
Transfection of a human topoisomerase II alpha gene into etoposide-resistant human breast tumor cells sensitizes the cells to etoposide.
Breast Neoplasms
Translocation t(4;11)(q21;q23) and MLL gene rearrangement in acute lymphoblastic leukemia secondary to anti topoisomerase II anticancer agents.
Breast Neoplasms
Triple negative breast cancer--current status and prospective targeted treatment based on HER1 (EGFR), TOP2A and C-MYC gene assessment.
Breast Neoplasms
Triple negative breast cancer: molecular profiling and prognostic impact in adjuvant anthracycline-treated patients.
Breast Neoplasms
Tumor Topoisomerase II Alpha Status and Response to Anthracycline-Based Neoadjuvant Chemotherapy in Breast Cancer.
Breast Neoplasms
Underpinning the repurposing of anthracyclines towards colorectal cancer: assessment of topoisomerase II alpha gene copy number alterations in colorectal cancer.
Breast Neoplasms
Utilization of fluorescence in situ hybridization with cytokeratin discriminators in TOP2A assessment of chemotherapy-treated patients with breast cancer.
Breast Neoplasms
Vacuolar ATPase driven potassium transport in highly metastatic breast cancer cells.
Breast Neoplasms
Vacuolar H+ ATPase expression and activity is required for Rab27B-dependent invasive growth and metastasis of breast cancer.
Breast Neoplasms
Vacuolar protein sorting 4B regulates apoptosis of intestinal epithelial cells via p38 MAPK in Crohn's disease.
Breast Neoplasms
Validity of the proliferation markers Ki67, TOP2A, and RacGAP1 in molecular subgroups of breast cancer.
Breast Neoplasms
WITHDRAWN: BRCA1 protein expression and TOP2A gene aberration and protein expression in four molecular subtypes of breast cancer.
Breast Neoplasms
[-Na(+)-K+ ATPase activity in vesicles of plasmatic membrane of breast cancer].
Breast Neoplasms
[An antigen related to the mouse mammary cancer virus env gene product, detected in human lymphocytes, is associated with human breast cancer]
Breast Neoplasms
[Auto-analysis of immunohistochemical findings for breast cancer using specified software and virtual microscopy].
Breast Neoplasms
[Correlation of TOP2A gene expression and survival of breast cancer patients].
Breast Neoplasms
[HER2 and topoisomerase II alpha: useful clinical markers in breast cancer]
Breast Neoplasms
[Impact of section thickness in detection of HER2 and TOP2A in breast cancer by FISH].
Breast Neoplasms
[Molecular Diagnostic and Targeted Therapy - "Barking Dogs are Going to Bite": Presentations from the 42nd Annual Meeting of the American Society of Clinical Oncology, Atlanta 2006.]
Breast Neoplasms
[Relevance between TOP2A, EGFR gene expression and efficacy of docetaxel plus epirubicin as neoadjuvant chemotherapy in triple negative breast cancer patients].
Breast Neoplasms
[Specific features of gene amplification on the long arm of chromosome 17 in different molecular genetic subtypes of breast cancer].
Breast Neoplasms
[The relationship between 99mTc-MIBI scintimammography of breast cancer and multidrug-resistant proteins]
Breast Neoplasms
[Topo II alpha in breast cancer: an update]
Breast Neoplasms
[Topoisomerase inhibitor upregulates MICA/B expression in breast cancer cells through ATM/ATR and NF-?B pathway].
Bronchitis
Coronavirus interactions with the cellular autophagy machinery.
Burkitt Lymphoma
Activation of p53 in MDM2-overexpressing cells through phosphorylation.
Burkitt Lymphoma
Elevated DNA topoisomerase II activity in nitrogen mustard-resistant human cells.
Burkitt Lymphoma
Isolation and characterization of a human cDNA clone encoding a novel DNA topoisomerase II homologue from HeLa cells.
Burkitt Lymphoma
Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II.
Candidiasis
Epidemiological study of Candida species in cutaneous candidiasis based on PCR using a primer mix specific for the DNA topoisomerase II gene.
Candidiasis
Synergistic interactions between ?-lapachone and fluconazole in the inhibition of CaCdr2p and CaMdr1p in Candida albicans.
Carcinogenesis
A Mechanistic and Structural Analysis of the Inhibition of Heat Shock Protein 90 by the Benzoquinone and Hydroquinone Ansamycins.
Carcinogenesis
Aberrant DNA topoisomerase II activity, radioresistance and inherited susceptibility to cancer.
Carcinogenesis
Adenosine triphosphatase, a new marker for the differentiation of putative precancerous foci induced in rat pancreas by azaserine.
Carcinogenesis
Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women.
Carcinogenesis
Autoantibody to DNA topoisomerase II in primary liver cancer
Carcinogenesis
Biochemical quantification of ATPase activities during liver carcinogenesis.
Carcinogenesis
Bioinformatic analysis identifies potentially key differentially expressed genes in oncogenesis and progression of clear cell renal cell carcinoma.
Carcinogenesis
CD26/dipeptidyl peptidase IV as a novel therapeutic target for cancer and immune disorders.
Carcinogenesis
Curcumin, a molecule that inhibits the Ca2+-ATPase of sarcoplasmic reticulum but increases the rate of accumulation of Ca2+.
Carcinogenesis
Cytochemical localization and biochemical analysis of the enzyme markers in human hepatoma cell lines.
Carcinogenesis
Detection of cell cycle-related factors in ameloblastomas.
Carcinogenesis
Detection of endogenous lithium in neuropsychiatric disorders--a model for biological transmutation.
Carcinogenesis
Discovering novel lung cancer associated antigens and the utilization of their autoantibodies in detection of lung cancer.
Carcinogenesis
DNA Double Strand Breaks and Chromosomal Translocations Induced by DNA Topoisomerase II.
Carcinogenesis
DOC45, a novel DNA damage-regulated nucleocytoplasmic ATPase that is overexpressed in multiple human malignancies.
Carcinogenesis
Effect of myeloid differentiation primary response gene 88 on expression profiles of genes during the development and progression of Helicobacter-induced gastric cancer.
Carcinogenesis
Establishment of a mini-gene expression database for bladder tumor.
Carcinogenesis
Expression of the vascular endothelial growth factor receptor-2/Flk-1 in breast carcinomas: correlation with proliferation.
Carcinogenesis
Histochemical comparison of focal losses of RNase and ATPase activities in preneoplastic rat livers.
Carcinogenesis
Hypothalamic digoxin, geomagnetic fields and human disease--a hypothesis.
Carcinogenesis
Identification of a novel amplicon at distal 17q containing the BIRC5/SURVIVIN gene in malignant peripheral nerve sheath tumours.
Carcinogenesis
Identification of therapeutic targets and mechanisms of tumorigenesis in non-small cell lung cancer using multiple-microarray analysis.
Carcinogenesis
Inhibition by 2,4-dinitrophenol of 9,10-dimethyl-1,2-benzanthracene carcinogenesis in the hamster cheek pouch.
Carcinogenesis
Inhibition of N-methyl-N-nitrosourea-induced mammary tumors in rats by the soybean isoflavones.
Carcinogenesis
Irradiation of rainbow trout at early life stages results in a proteomic legacy in adult gills. Part B; the effect of a second radiation dose, after one year, on the proteomic responses in the irradiated and non-irradiated bystander fish.
Carcinogenesis
Merkel cell carcinomas: expression of S-phase kinase-associated protein 2 (Skp2), p27, and proliferation markers.
Carcinogenesis
Methods for In Vivo Functional Studies of Chromatin-Modifying Enzymes in Early Steps of Colon Carcinogenesis.
Carcinogenesis
MiR-599 targeting TOP2A inhibits the malignancy of bladder cancer cells.
Carcinogenesis
Mutual regulation of MDM4 and TOP2A in cancer cell proliferation.
Carcinogenesis
Oncogenesis Caused by Loss of the SNF5 Tumor Suppressor Is Dependent on Activity of BRG1, the ATPase of the SWI/SNF Chromatin Remodeling Complex.
Carcinogenesis
Overexpression of ICBP90, a novel CCAAT-binding protein, overcomes cell contact inhibition by forcing topoisomerase II alpha expression.
Carcinogenesis
Overexpression of the BRIP1 ameliorates chemosensitivity to cisplatin by inhibiting Rac1 GTPase activity in cervical carcinoma HeLa cells.
Carcinogenesis
Prognostic and immunological value of ATP6AP1 in breast cancer: implications for SARS-CoV-2.
Carcinogenesis
Proliferation and invasion of colon cancer cells are suppressed by knockdown of TOP2A.
Carcinogenesis
Relative molecular similarity in selected chemical carcinogens and the nucleoside triphosphate chain.
Carcinogenesis
Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation.
Carcinogenesis
Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.
Carcinogenesis
RHPN1?AS1 promotes ovarian carcinogenesis by sponging miR?6884?5p thus releasing TOP2A mRNA.
Carcinogenesis
Screening and authentication of molecular markers in malignant glioblastoma based on gene expression profiles.
Carcinogenesis
The AAA(+) ATPase RUVBL2 is a critical mediator of MLL-AF9 oncogenesis.
Carcinogenesis
The ATPase Pontin is a key cell cycle regulator by amplifying E2F1 transcription response in glioma.
Carcinogenesis
The H(+)-ATP synthase: A gate to ROS-mediated cell death or cell survival.
Carcinogenesis
The loss of sarco/endoplasmic reticulum calcium transport ATPase 3 expression is an early event during the multistep process of colon carcinogenesis.
Carcinogenesis
The significance of Epstein Barr Virus (EBV) & DNA Topoisomerase II alpha (DNA-Topo II alpha) immunoreactivity in normal oral mucosa, Oral Epithelial Dysplasia (OED) and Oral Squamous Cell Carcinoma (OSCC).
Carcinogenesis
Thyroid Hormone Receptor ? Suppression of RUNX2 Is Mediated by Brahma-Related Gene 1-Dependent Chromatin Remodeling.
Carcinogenesis
TOP2A Promotes Lung Adenocarcinoma Cells' Malignant Progression and Predicts Poor Prognosis in Lung Adenocarcinoma.
Carcinogenesis
TOP2A Promotes Tumorigenesis of High-grade Serous Ovarian Cancer by Regulating the TGF-?/Smad Pathway.
Carcinogenesis
Topoisomerase II alpha promotes gallbladder cancer proliferation and metastasis through activating phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway.
Carcinogenesis
Topoisomerase IIalpha gene expression is regulated by the p53 tumor suppressor gene in nonsmall cell lung carcinoma patients.
Carcinogenesis
Topoisomerase IIalpha in Wilms' tumour: gene alterations and immunoexpression.
Carcinogenesis
Transgenic expression of interferon-? in mouse stomach leads to inflammation, metaplasia, and dysplasia.
Carcinogenesis
[2009 update in salivary gland tumoral pathology]
Carcinogenesis
[Bioinformatics Analysis of Hepatocellular Carcinoma Related Gene and Construction of a Protein-Protein Interaction Network].
Carcinogenesis
[Topoisomerase IIalpha and HER2/neu gene alterations and their correlation in pancreatic ductal adenocarcinomas]
Carcinoid Tumor
ECL-cell carcinoids and carcinoma in patients homozygous for an inactivating mutation in the gastric H(+) K(+) ATPase alpha subunit.
Carcinoid Tumor
Pharmacological management of patients with peptic ulcer disease: prospects for the late 1980's.
Carcinoid Tumor
Primary strumal carcinoid tumor of the ovary with multiple bone and breast metastases.
Carcinoma
15-Deoxy-?12,14-prostaglandin J2 enhanced the anti-tumor activity of camptothecin against renal cell carcinoma independently of topoisomerase-II and PPAR? pathways.
Carcinoma
A comparison of the effects of aphidicolin and other inhibitors on topoisomerase II-directed cytotoxic drugs.
Carcinoma
A genetically engineered ovarian cancer mouse model based on fallopian tube transformation mimics human high-grade serous carcinoma development.
Carcinoma
A novel 9-aza-anthrapyrazole effective against human prostatic carcinoma xenografts.
Carcinoma
A type-II DNA topoisomerase and a catenating protein from the transplantable VX2 carcinoma.
Carcinoma
Activation of the tumor metastasis suppressor gene, KAI1, by etoposide is mediated by p53 and c-Jun genes.
Carcinoma
Adenosine triphosphatases as histochemical markers for the cell of origin in experimental mammary carcinoma.
Carcinoma
alpha-Methylacyl coenzyme A racemase, Ki-67, and topoisomerase IIalpha in cystoprostatectomies with incidental prostate cancer.
Carcinoma
Ammonium tetrathiomolybdate enhances the antitumor effect of cisplatin via the suppression of ATPase copper transporting beta in head and neck squamous cell carcinoma.
Carcinoma
Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIalpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab.
Carcinoma
Amplification of HER2 and TOP2A and deletion of TOP2A genes in a series of Taiwanese breast cancer.
Carcinoma
Amplification of HER2 and TOP2A and deletion of TOP2A genes in breast cancer investigated by new FISH probes.
Carcinoma
Analysis of EGFR, HER2, and TOP2A gene status and chromosomal polysomy in gastric adenocarcinoma from Chinese patients.
Carcinoma
Apoptosis and cancer chemotherapy.
Carcinoma
Apoptotic and proliferative activity in ovarian benign, borderline and malignant tumors.
Carcinoma
Arsenic trioxide exposure to ovarian carcinoma cells leads to decreased level of topoisomerase II and cytotoxicity.
Carcinoma
Association between clinical pathology and multiple genes mRNA expression in Chinese patients with NSCLC.
Carcinoma
ATPase inhibitory factor 1 inhibition improves the antitumor of YC-1 against hepatocellular carcinoma.
Carcinoma
Autocrine production of interleukin 1beta confers constitutive nuclear factor kappaB activity and chemoresistance in pancreatic carcinoma cell lines.
Carcinoma
c-Myb trans-activates the human DNA topoisomerase IIalpha gene promoter.
Carcinoma
Cancer cell adaptation to chemotherapy.
Carcinoma
Changes in subcellular distribution of topoisomerase IIalpha correlate with etoposide resistance in multicell spheroids and xenograft tumors.
Carcinoma
Changes of adenosinetriphosphatase (ATPase) activities in lymphocytes from patients with carcinomas of the gastrointestinal tract.
Carcinoma
Changes of enzyme activities recognized in lymphocytes from patients with carcinoma of the gastrointestinal tract.
Carcinoma
Characteristics of human gastric carcinoma cell lines with induced multidrug resistance.
Carcinoma
Characterization of topoisomerase II ? and minichromosome maintenance protein 2 expression in anal carcinoma.
Carcinoma
Clonality characterization of natural epitope-specific antibodies against the tumor-related antigen topoisomerase IIa by peptide chip and proteome analysis: a pilot study with colorectal carcinoma patient samples.
Carcinoma
Comparison of DNA topoisomerase II alpha expression in small cell and nonsmall cell carcinoma of the lung. In search of a mechanism of chemotherapeutic response.
Carcinoma
Comparison of the effects of treatment with the polyamine analogue N1,N8 bis(ethyl)spermidine (BESpd) or difluoromethylornithine (DFMO) on the Topoisomerase II mediated formation of 4'-(9-acridinylamino) methanesulfon-m-anisidide (m-AMSA) induced cleavable complex in the human lung carcinoma line NCI H157.
Carcinoma
Comparison of the mRNA expression of factors related to drug resistance in lung tumors and adjacent normal tissue.
Carcinoma
Complex formation between metabolic enzymes in tumor cells: Unfolding the MDR1-IDE paradigm.
Carcinoma
Contribution of c-erbB-2 and topoisomerase IIalpha to chemoresistance in ovarian cancer.
Carcinoma
Correlation between p53, c-erbB-2, and topoisomerase II alpha expression, DNA ploidy, hormonal receptor status and proliferation in 356 node-negative breast carcinomas: prognostic implications.
Carcinoma
Correlation between Topo II alpha expression and chemosensitivity testing for Topo II-targeting drugs in gynaecological carcinomas.
Carcinoma
CORRELATIONSHIP OF CATHEPSIN D AND TOPOISOMERASE II ALPHA WITH NUCLEAR GRADING IN BREAST CANCERS.
Carcinoma
Cytotoxicity mediated by tumor necrosis factor in variant subclones of the ME-180 cervical carcinoma line: modulation by specific inhibitors of DNA topoisomerase II.
Carcinoma
Decreased levels of topoisomerase II alpha in human renal cell carcinoma lines resistant to etoposide.
Carcinoma
Delphinidin Modulates the DNA-Damaging Properties of Topoisomerase II Poisons.
Carcinoma
Detecting high-grade cervical disease on ASC-H cytology: role of BD ProEx C and Digene Hybrid Capture II HPV DNA testing.
Carcinoma
Dicationic bis(9-methylphenazine-1-carboxamides): relationships between biological activity and linker chain structure for a series of potent topoisomerase targeted anticancer drugs.
Carcinoma
Differential expression of alkaline phosphatase and ATPase activities in human colon carcinoma cell line HT-29.18 during differentiation.
Carcinoma
Differential expression of DNA topoisomerase II alpha and -beta in P-gp and MRP-negative VM26, mAMSA and mitoxantrone-resistant sublines of the human SCLC cell line GLC4.
Carcinoma
Differential expression of topoisomerase IIalpha protein in salivary gland carcinomas: histogenetic and prognostic implications.
Carcinoma
Distribution of adenosine triphosphatase in infiltrating ductal carcinoma and non-neoplastic breast.
Carcinoma
DNA topoisomerase I and IIalpha expression in penile carcinomas: assessing potential tumour chemosensitivity.
Carcinoma
DNA topoisomerase II alpha and Ki-67 in human adrenocortical neoplasms: a possible marker of differentiation between adenomas and carcinomas.
Carcinoma
DNA topoisomerase II alpha expression is associated with alkylating agent resistance.
Carcinoma
ECL-cell carcinoids and carcinoma in patients homozygous for an inactivating mutation in the gastric H(+) K(+) ATPase alpha subunit.
Carcinoma
Enhanced coexpression of YB-1 and DNA topoisomerase II alpha genes in human colorectal carcinomas.
Carcinoma
Enhanced topoisomerase I activity and increased topoisomerase II alpha content in cisplatin-resistant cancer cell lines.
Carcinoma
Enzyme levels in the growing and spontaneously regressing Flexner-Jobling carcinoma. II. ATPase and glycolysis.
Carcinoma
Evaluation of topoisomerase II, Ki-67 and P53 expression in non-muscle invasive urothelial carcinoma and their clinical significance.
Carcinoma
Evaluation of topoisomerase II, ki-67, and P53 expression in non-muscle-invasive urothelial carcinoma and their clinical significance.
Carcinoma
Expression of ATP6V1C1 during oral carcinogenesis.
Carcinoma
Expression of cellular apoptosis susceptibility protein in serous ovarian carcinoma: a clinicopathologic and immunohistochemical study.
Carcinoma
Expression of DNA topoisomerase I and DNA topoisomerase II-alpha in carcinoma of the colon.
Carcinoma
Expression of drug resistance-related genes in head and neck squamous cell carcinomas and normal mucosa.
Carcinoma
Expression of ERCC1, TYMS, TUBB3, RRM1 and TOP2A in patients with esophageal squamous cell carcinoma: A hierarchical clustering analysis.
Carcinoma
Expression of genes involved in chemoresistance, proliferation and apoptosis in clinical samples of renal cell carcinoma and correlation with clinical outcome.
Carcinoma
Expression of multidrug resistance-related genes in oral squamous cell carcinomas.
Carcinoma
Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways.
Carcinoma
Expression of resistance factors (P-glycoprotein, glutathione S-transferase-pi, and topoisomerase II) and their interrelationship to proto-oncogene products in renal cell carcinomas.
Carcinoma
Expression of several resistance mechanisms in untreated human kidney and lung carcinomas.
Carcinoma
Expression of the MRP2 gene-encoded conjugate export pump in human kidney proximal tubules and in renal cell carcinoma.
Carcinoma
Expression of topoisomerase II alpha, Ki-67 and p53 in early stage laryngeal carcinomas not featuring vocal cord fixation.
Carcinoma
EXPRESSION OF TOPOISOMERASE II ALPHA, KI67 AND P53 IN PRIMARY NON-MUSCLE-INVASIVE UROTHELIAL BLADDER CARCINOMA.
Carcinoma
Expression of topoisomerase II and Ki-67 in cervical carcinoma--clinicopathological study using immunohistochemistry.
Carcinoma
Expression of topoisomerase II, catalase, metallothionein and thymidylate-synthase in human squamous cell lung carcinomas and their correlation with doxorubicin resistance and with patients' smoking habits.
Carcinoma
Expression of topoisomerase IIalpha, Ki-67, proliferating cell nuclear antigen, p53, and argyrophilic nucleolar organizer regions in vulvar squamous lesions.
Carcinoma
Expression of Y box-binding protein-1 correlates with DNA topoisomerase IIalpha and proliferating cell nuclear antigen expression in lung cancer.
Carcinoma
Expression patterns of multidrug-resistance (MDR1), multidrug resistance-associated protein (MRP),glutathione-S-transferase-pi (GST-pi) and DNA topoisomerase II (Topo II) genes in renal cell carcinomas and normal kidney.
Carcinoma
Gene expression correlating with response to paclitaxel in ovarian carcinoma xenografts.
Carcinoma
Gene Silencing Associated with SWI/SNF Complex Loss during NSCLC Development.
Carcinoma
Genomic landscape of small cell carcinoma of the breast contrasted to small cell carcinoma of the lung.
Carcinoma
Green tea constituent (--)-epigallocatechin-3-gallate inhibits topoisomerase I activity in human colon carcinoma cells.
Carcinoma
HER2 and TOP2A Gene Amplification and Protein Expression in Upper Tract Urothelial Carcinomas.
Carcinoma
Higher Expression of Topoisomerase II Alpha Is an Independent Marker of Increased Risk of Cancer-specific Death in Patients with Clear Cell Renal Cell Carcinoma.
Carcinoma
Human DNA topoisomerase II-alpha.
Carcinoma
Hypophosphorylation of topoisomerase IIalpha in etoposide (VP-16)-resistant human carcinoma cell lines associated with carboxy-terminal truncation.
Carcinoma
Identification of pivotal cellular factors involved in HPV-induced dysplastic and neoplastic cervical pathologies.
Carcinoma
Identification of potassium flux pathways and their role in the cytotoxicity of estramustine in human malignant glioma, prostatic carcinoma and pulmonary carcinoma cell lines.
Carcinoma
Identification of tumor-associated antigens of lung cancer: SEREX combined with bioinformatics analysis.
Carcinoma
Identifying a Novel Biomarker TOP2A of Clear Cell Renal Cell Carcinoma (ccRCC) Associated with Smoking by Co-Expression Network Analysis.
Carcinoma
Immunohistochemical analysis of the distribution of the human ATPase (hASNA-I) in normal tissues and its overexpression in breast adenomas and carcinomas.
Carcinoma
Immunohistochemical and two-parameter flow cytometric studies of DNA topoisomerase II alpha in human epithelial ovarian carcinoma and germ cell tumor.
Carcinoma
Immunohistochemical and ultrastructural study of Langerhans's cells in squamous cell carcinoma of the cervix.
Carcinoma
Immunohistochemical detection of DNA topoisomerase type II alpha and Ki-67 in adenoid cystic carcinoma and pleomorphic adenoma of the salivary gland.
Carcinoma
Immunohistochemical detection of P glycoprotein, glutathione S transferase and DNA topoisomerase II in human tumors.
Carcinoma
Immunohistochemical expression of topoisomerase II alpha and Her-2/neu in prostatic carcinoma and benign prostatic hyperplasia.
Carcinoma
Immunohistochemical expression of topoisomerase IIalpha (Topo IIalpha) and multidrug resistance-associated protein (MRP), plus chemosensitivity testing, as chemotherapeutic indices of ovarian and endometrial carcinomas.
Carcinoma
Immunohistochemical staining for DNA topoisomerase II-alpha in benign, premalignant, and malignant lesions of the prostate.
Carcinoma
Immunohistochemical study of DNA topoisomerase I, DNA topoisomerase II alpha, p53, and Ki-67 in oral preneoplastic lesions and oral squamous cell carcinomas.
Carcinoma
In vivo and in vitro assessment of the action of SN 28049, a benzonaphthyridine derivative targeting topoisomerase II, on the murine Colon 38 carcinoma.
Carcinoma
Induction of apoptosis of human tumor cells by a 4,9-diazapyrenium derivative and its affects on topoisomerase-II action.
Carcinoma
Inhibition of type II topoisomerase by fostriecin.
Carcinoma
Isolation and characterization of a human cDNA clone encoding a novel DNA topoisomerase II homologue from HeLa cells.
Carcinoma
Isolation and characterization of plasma membranes from transplantable human astrocytoma, oat cell carcinoma, and melanomas.
Carcinoma
Isolation, DNA topoisomerase-II inhibition, and cytotoxicity of three new terpenoids from the bark of Macaranga tanarius.
Carcinoma
Lanostanoids from Fungi: A Group of Potential Anticancer Compounds.
Carcinoma
LncRNA SNHG3 promotes clear cell renal cell carcinoma proliferation and migration by upregulating TOP2A.
Carcinoma
Loss of switch/sucrose non-fermenting complex protein expression is associated with dedifferentiation in endometrial carcinomas.
Carcinoma
Lymphocyte ATPase activity in patients with carcinoma of the larynx. A follow-up study on 45 patients.
Carcinoma
Markers of drug resistance in relapsing colon cancer.
Carcinoma
Merkel cell carcinomas: expression of S-phase kinase-associated protein 2 (Skp2), p27, and proliferation markers.
Carcinoma
MicroRNA-520f suppresses growth of gastric carcinoma cells by target ATPase family AAA domain-containing protein 2 (ATAD2).
Carcinoma
MicroRNAs contribute to the chemoresistance of cisplatin in tongue squamous cell carcinoma lines.
Carcinoma
Mining expression and prognosis of topoisomerase isoforms in non-small-cell lung cancer by using Oncomine and Kaplan-Meier plotter.
Carcinoma
Molecular analysis of the topoisomerase II alpha gene and its expression in human ovarian cancer.
Carcinoma
Multidrug resistance-associated biomarkers PGP, GST-pi, Topo-II and LRP as prognostic factors in primary ovarian carcinoma.
Carcinoma
Multiple mechanisms confer different drug-resistant phenotypes in pancreatic carcinoma cells.
Carcinoma
New TRAP1 and Hsp90 chaperone inhibitors with cationic components: Preliminary studies on mitochondrial targeting.
Carcinoma
Novel carbamate analogues of amsacrine with activity against non-cycling murine and human tumour cells.
Carcinoma
Obg-like ATPase 1 inhibited oral carcinoma cell metastasis through TGF?/SMAD2 axis in vitro.
Carcinoma
Oral etoposide for Merkel cell carcinoma in patients previously treated with intravenous etoposide.
Carcinoma
Over-Expression of Topoisomerase IIalpha is Related to the Grade of Cervical Intraepithelial Neoplasia (CIN) and High-Risk Human Papillomavirus (HPV), but does not Predict Prognosis in Cervical Cancer or HPV Clearance after Cone Treatment.
Carcinoma
Overexpression of ATPase Na+/+ transporting alpha 1 polypeptide, ATP1A1, correlates with clinical diagnosis and progression of esophageal squamous cell carcinoma.
Carcinoma
Overexpression of Mitochondrial IF1 Prevents Metastatic Disease of Colorectal Cancer by Enhancing Anoikis and Tumor Infiltration of NK Cells.
Carcinoma
Overexpression of the ATPase Inhibitory Factor 1 Favors a Non-metastatic Phenotype in Breast Cancer.
Carcinoma
Overexpression of thymosin beta-4 renders SW480 colon carcinoma cells more resistant to apoptosis triggered by FasL and two topoisomerase II inhibitors via downregulating Fas and upregulating Survivin expression, respectively.
Carcinoma
Oxidative phosphorylation and ATPase activities of human tumor mitochondria.
Carcinoma
P53, MAPK, topoisomerase II alpha and Ki67 immunohistochemical expression and KRAS/BRAF mutation in ovarian serous carcinomas.
Carcinoma
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Carcinoma
Phase 2 trial of the topoisomerase II inhibitor, amrubicin, as second-line therapy in patients with metastatic urothelial carcinoma.
Carcinoma
PHOSPHORYLATION AND ATPASE ACTIVITY OF LIVER MITOCHONDRIA FROM SWISS MICE BEARING KREBS-2 CARCINOMA.
Carcinoma
Phosphorylation of DNA topoisomerase II in a human tumor cell line.
Carcinoma
Potentiation of tumour necrosis factor-mediated cell killing by VP16 on human ovarian cancer cell lines. In vitro results and clinical implications.
Carcinoma
Predictive value of topoisomerase II alpha immunostaining in urothelial bladder carcinoma.
Carcinoma
Prognostic impact of KI67, p53, human epithelial growth factor receptor 2, topoisomerase IIalpha, epidermal growth factor receptor, and nm23 expression of ovarian carcinomas and disseminated tumor cells in the bone marrow.
Carcinoma
Prognostic significance of cyclooxygenase-2 and DNA topoisomerase IIalpha expression in oral carcinoma.
Carcinoma
Prognostic significance of Ki-67 and topoisomerase IIalpha expression in infiltrating ductal carcinoma of the breast. A multivariate analysis of 863 cases.
Carcinoma
Prognostic value of the Cu-transporting ATPase in ovarian carcinoma patients receiving cisplatin-based chemotherapy.
Carcinoma
Prognostic value of TOP2A in bladder urothelial carcinoma and potential molecular mechanisms.
Carcinoma
Protein expression and gene copy number analysis of topoisomerase 2alpha, HER2 and P53 in minimally invasive urothelial carcinoma of the urinary bladder--a multitissue array study with prognostic implications.
Carcinoma
Purification of GidA protein, a novel topoisomerase II inhibitor produced by Streptomyces flavoviridis
Carcinoma
Purification of GidA protein, a novel topoisomerase II inhibitor produced by Streptomyces flavoviridis.
Carcinoma
Quantitation of DNA topoisomerase II alpha messenger ribonucleic acid levels in a small cell lung cancer cell line and two drug resistant sublines using a polymerase chain reaction-aided transcript titration assay.
Carcinoma
Radioresistance in a human laryngeal squamous cell carcinoma cell line is associated with DNA methylation changes and topoisomerase II alpha.
Carcinoma
Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small cell lung carcinoma cell line.
Carcinoma
Relationship of cell cycle parameters to in vitro and in vivo chemosensitivity for a series of Lewis lung carcinoma lines.
Carcinoma
Replication Protein A (RPA1, RPA2 and RPA3) expression in gastric cancer: correlation with clinicopathologic parameters and patients' survival.
Carcinoma
Resistance mechanisms and their regulation in lung cancer.
Carcinoma
Role of NF-kappaB signaling in hepatocyte growth factor/scatter factor-mediated cell protection.
Carcinoma
Roles of NF-kappaB and 26 S proteasome in apoptotic cell death induced by topoisomerase I and II poisons in human nonsmall cell lung carcinoma.
Carcinoma
Sarcoendoplasmic reticulum Ca(2+) ATPase type 2 downregulated in human oral squamous cell carcinoma.
Carcinoma
Screening feature genes of lung carcinoma with DNA microarray analysis.
Carcinoma
Selection of a subpopulation with fewer DNA topoisomerase II alpha gene copies in a doxorubicin-resistant cell line panel.
Carcinoma
Selective cellular uptake and retention of SN 28049, a new DNA-binding topoisomerase II-directed antitumor agent.
Carcinoma
Small-molecule inhibitors targeting eIF4A in leukemia.
Carcinoma
Solubilization of a cell surface ATPase from Ehrlich ascites carcinoma cells.
Carcinoma
Structure-activity relationships of podophyllin congeners that inhibit topoisomerase II.
Carcinoma
Structure-activity studies of novobiocin analogs as modulators of the cytotoxicity of etoposide (VP-16).
Carcinoma
Subcellular distribution of the alpha and beta topoisomerase II-DNA complexes stabilized by VM-26.
Carcinoma
Synergistic action of tiazofurin and genistein in human ovarian carcinoma cells.
Carcinoma
Synergistic action of tiazofurin and genistein on growth inhibition and differentiation of K-562 human leukemic cells.
Carcinoma
Synthesis and cytotoxicity of oligomycin A derivatives modified in the side chain.
Carcinoma
Synthesis, DNA binding, topoisomerase II inhibition and cytotoxicity of two guanidine-containing anthracene-9,10-diones.
Carcinoma
T1 High Grade Bladder Carcinoma Outcome: The Role of P16, Topoisomerase-Ii Alpha, Survivin and E-Cadherin.
Carcinoma
The activity of topoisomerases is related to the grade and stage in human renal cell carcinoma.
Carcinoma
The association between the p53/topoisomerase I and p53/ topoisomerase IIalpha immunophenotypes and the progression of ovarian carcinomas.
Carcinoma
The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex identity and catalytic activity-independent genomic targeting.
Carcinoma
The common occurrence of ATP diphosphohydrolase in mammalian plasma membranes.
Carcinoma
The genomic profile of HER2-amplified breast cancers: the influence of ER status.
Carcinoma
The inhibition of cellular recovery in human tumour cells by inhibitors of topoisomerase.
Carcinoma
The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancer.
Carcinoma
The olivacine S16020 enhances the antitumor effect of ionizing radiation without increasing radio-induced mucositis.
Carcinoma
The prognostic significance of proliferative activity, apoptosis and expression of DNA topoisomerase II alpha in multimodally-treated oesophageal squamous cell carcinoma.
Carcinoma
The Role of Phenethyl Isothiocyanate on Bladder Cancer ADM Resistance Reversal and Its Molecular Mechanism.
Carcinoma
The significance of Epstein Barr Virus (EBV) & DNA Topoisomerase II alpha (DNA-Topo II alpha) immunoreactivity in normal oral mucosa, Oral Epithelial Dysplasia (OED) and Oral Squamous Cell Carcinoma (OSCC).
Carcinoma
Therapy-related acute myelogenous leukemia associated with 11q23 chromosomal abnormalities and topoisomerase II inhibitors: report of four additional cases and brief commentary.
Carcinoma
TOP2A overexpression as a poor prognostic factor in patients with nasopharyngeal carcinoma.
Carcinoma
TOP2A, HELLS, ATAD2, and TET3 Are Novel Prognostic Markers in Renal Cell Carcinoma.
Carcinoma
Topoisomerase 2A gene amplification in breast cancer. Critical evaluation of different FISH probes.
Carcinoma
Topoisomerase II alpha expression and cytotoxicity of anthracyclines in human neoplastic cells.
Carcinoma
Topoisomerase II alpha expression in breast ductal invasive carcinomas and correlation with clinicopathological variables.
Carcinoma
Topoisomerase II alpha expression in esophageal squamous cell carcinoma.
Carcinoma
Topoisomerase II alpha expression in squamous cell carcinomas of the head and neck.
Carcinoma
Topoisomerase II antagonism and anticancer activity of coordinated derivatives of [RuCl(2)(C(6)H(6))(dmso)].
Carcinoma
Topoisomerase II as a target of VM-26 and 4'-(9-acridinylamino)methanesulfon-m-aniside in atypical multidrug resistant human small cell lung carcinoma cells.
Carcinoma
Topoisomerase II trapping agent teniposide induces apoptosis and G2/M or S phase arrest of oral squamous cell carcinoma.
Carcinoma
Topoisomerase IIa expression in laryngeal and oral carcinomas: is it a reliable prognostic molecular marker?
Carcinoma
Topoisomerase IIa protein expression analysis in oral squamous cell carcinoma.
Carcinoma
Topoisomerase IIa Protein Expression Patterns in Laryngeal Squamous Cell Carcinoma.
Carcinoma
Topoisomerase IIalpha expression in pituitary adenomas and carcinomas: relationship to tumor behavior.
Carcinoma
Topoisomerase IIalpha gene amplification in gastric carcinomas: correlation with the HER2 gene. An immunohistochemical, immunoblotting, and multicolor fluorescence in situ hybridization study.
Carcinoma
Topoisomerase IIalpha gene expression is regulated by the p53 tumor suppressor gene in nonsmall cell lung carcinoma patients.
Carcinoma
Topoisomerase IIalpha mRNA and protein expression in ovarian carcinoma: correlation with clinicopathological factors and prognosis.
Carcinoma
Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis.
Carcinoma
Upregulation of topoisomerase IIalpha expression in advanced gallbladder carcinoma: a potential chemotherapeutic target.
Carcinoma
Validity of the proliferation markers Ki67, TOP2A, and RacGAP1 in molecular subgroups of breast cancer.
Carcinoma
Vascular endothelial growth factor expression in serous ovarian carcinoma: relationship with topoisomerase II alpha and prognosis.
Carcinoma
[Changes in ATPase activity recognized in granulocytes from patients with carcinomas of the gastrointestinal tract]
Carcinoma
[Differential expression of immunohistochemical markers between cardiac carcinoma and carcinoma in antrum of stomach and correlation thereof with clinicopathological factors]
Carcinoma
[Expression and implication of Pgp, MRP, LRP, GST-pi, Topo II alpha in tongue squamous cell carcinoma]
Carcinoma
[Expression and significance of MRP, GST-pi, Topo IIalpha, and LRP in gastric carcinoma]
Carcinoma
[Expression and significance of P-glycoprotein, glutathione S-transferase-pi and Topoisomerase II in gastric carcinomas]
Carcinoma
[Expression of c-erbB-2 and topoisomerase II alpha in relation to chemoresistance in ovarian cancer]
Carcinoma
[HER-2 and TOP 2A gene amplifications in urinary bladder carcinoma]
Carcinoma
[Relationship of cyclooxygenase-2 and multidrug resistance associated factors to chemosensitivities in gastrointestinal carcinomas]
Carcinoma
[Secondary TFE3-associated renal cell carcinoma in a child treated for Ewing sarcoma].
Carcinoma
[Study on the relationship among multidrug resistance factor expression of lung cancer tissues and clinicopathological characteristics in patients with lung cancer.]
Carcinoma
[The expression of ki-67, topoIIalpha in laryngeal squamous cell carcinoma]
Carcinoma
[The expression of MRP, GST-pi, Topo IIalpha and COX-2 in epithelial ovarian cancer and its relationship to drug resistance and prognosis]
Carcinoma
[The role of stromal components and Ca++ ATPase in pleomorphic adenoma and adenoid cystic carcinoma]
Carcinoma
[Topoisomerase IIalpha and HER2/neu gene alterations and their correlation in pancreatic ductal adenocarcinomas]
Carcinoma, Acinar Cell
Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways.
Carcinoma, Adenoid Cystic
Differential expression of topoisomerase IIalpha protein in salivary gland carcinomas: histogenetic and prognostic implications.
Carcinoma, Adenoid Cystic
Immunohistochemical detection of DNA topoisomerase type II alpha and Ki-67 in adenoid cystic carcinoma and pleomorphic adenoma of the salivary gland.
Carcinoma, Adenoid Cystic
[Multiple trichoepitheliomas, cylindromas and milia. An entity]
Carcinoma, Adenoid Cystic
[The role of stromal components and Ca++ ATPase in pleomorphic adenoma and adenoid cystic carcinoma]
Carcinoma, Ductal
Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women.
Carcinoma, Ductal
Distribution of adenosine triphosphatase in infiltrating ductal carcinoma and non-neoplastic breast.
Carcinoma, Ductal
Evaluation of the predictive value of topoisomerase II alpha in patients with breast carcinoma.
Carcinoma, Ductal
Extra copies of chromosomes 16 and X in invasive breast carcinomas are related to aggressive phenotype and poor prognosis.
Carcinoma, Ductal
Interphase cytogenetic analysis of erbB2 and topoII alpha co-amplification in invasive breast cancer and polysomy of chromosome 17 in ductal carcinoma in situ.
Carcinoma, Ductal
MET and PTEN gene copy numbers and Ki-67 protein expression associate with pathologic complete response in ERBB2-positive breast carcinoma patients treated with neoadjuvant trastuzumab-based therapy.
Carcinoma, Ductal
Prognostic significance of Ki-67 and topoisomerase IIalpha expression in infiltrating ductal carcinoma of the breast. A multivariate analysis of 863 cases.
Carcinoma, Ductal
Topoisomerase II alpha--a fundamental prognostic factor in breast carcinoma.
Carcinoma, Ductal
Topoisomerase IIalpha expression in ductal carcinoma in situ of the breast: a preliminary study.
Carcinoma, Ehrlich Tumor
Action of the antitumor and antispermatogenic agent lonidamine on electron transport in Ehrlich ascites tumor mitochondria.
Carcinoma, Ehrlich Tumor
ATPase activity of P-glycoprotein related to emergence of drug resistance in Ehrlich ascites tumor cell lines.
Carcinoma, Ehrlich Tumor
Decreased DNA topoisomerase II in daunorubicin-resistant Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
Mammalian protein homologous to VAT-1 of Torpedo californica: isolation from Ehrlich ascites tumor cells, biochemical characterization, and organization of its gene.
Carcinoma, Ehrlich Tumor
Resolution and reconstitution of biological pathways from 1919 to 1984.
Carcinoma, Ehrlich Tumor
The Crabtree effect: a new look at the old problem.
Carcinoma, Ehrlich Tumor
The role of ATPase in glycolysis of Ehrlich ascites tumor cells.
Carcinoma, Ehrlich Tumor
[ATPase and AMPase activity in the mitochondria of two ascitic tumors: ascites hepatoma of the rat and Ehrlich ascites tumor.]
Carcinoma, Ehrlich Tumor
[HCO3-sensitive adenosinetriphosphatase from ascites tumour cells]
Carcinoma, Ehrlich Tumor
[Modifying effect of ionizing radiation on the transmembrane transport of sodium ions in Ehrlich carcinoma tumor cells]
Carcinoma, Embryonal
DNA topoisomerase I and II expression in drug resistant germ cell tumours.
Carcinoma, Embryonal
Possible role of DNA topoisomerase II on transcription of the homeobox gene Hox-2.1 in F9 embryonal carcinoma cells.
Carcinoma, Embryonal
Topoisomerase II alpha expression in testicular germ cell tumors.
Carcinoma, Embryonal
Ultrastructural localization of membrane phosphatases in teratocarcinoma and early embryos.
Carcinoma, Hepatocellular
3,3'-diindolylmethane is a novel topoisomerase IIalpha catalytic inhibitor that induces S-phase retardation and mitotic delay in human hepatoma HepG2 cells.
Carcinoma, Hepatocellular
A high-affinity (Ca2+ + Mg2+)-ATPase in plasma membranes of rat ascites hepatoma AH109A cells.
Carcinoma, Hepatocellular
Association between reversal of multidrug resistance by methyl jasmonate and P-glycoprotein ATPase activity in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Association of topoisomerase II with the hepatoma cell nuclear matrix: the role of intermolecular disulfide bond formation.
Carcinoma, Hepatocellular
ATPase inhibitory factor 1 inhibition improves the antitumor of YC-1 against hepatocellular carcinoma.
Carcinoma, Hepatocellular
ATPase Inhibitory Factor 1 Promotes Hepatocellular Carcinoma Progression After Insufficient Radiofrequency Ablation, and Attenuates Cell Sensitivity to Sorafenib Therapy.
Carcinoma, Hepatocellular
Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells.
Carcinoma, Hepatocellular
Binding of wild-type p53 by topoisomerase II and overexpression of topoisomerase II in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
CCNB2, TOP2A, and ASPM Reflect the Prognosis of Hepatocellular Carcinoma, as Determined by Weighted Gene Coexpression Network Analysis.
Carcinoma, Hepatocellular
Clinical characterization for proliferation and metastasis in advanced hepatocellular carcinoma patients.
Carcinoma, Hepatocellular
Components of intrinsic drug resistance in the rat hepatoma.
Carcinoma, Hepatocellular
Contact-mediated changes in ATPase activity at the surface of primary cultured hepatoma cells.
Carcinoma, Hepatocellular
Cytochemical localization and biochemical analysis of the enzyme markers in human hepatoma cell lines.
Carcinoma, Hepatocellular
DNA topoisomerase II? and Ki67 are prognostic factors in patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
Effects of cinobufacini injection on cell proliferation and the expression of topoisomerases in human HepG-2 hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
High expression of TOP2A in hepatocellular carcinoma is associated with disease progression and poor prognosis.
Carcinoma, Hepatocellular
Identification of Tumor Antigen AF20 as Glycosylated Transferrin Receptor 1 in Complex with Heat Shock Protein 90 and/or Transporting ATPase.
Carcinoma, Hepatocellular
Increased content of natural ATPase inhibitor in tumor mitochondria.
Carcinoma, Hepatocellular
Integrated Bioinformatics Analysis of the Clinical Value and Biological Function of ATAD2 in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Interferon-alpha modulates resistance to cisplatin in three human hepatoma cell lines.
Carcinoma, Hepatocellular
Involvement of AP-2 binding sites in regulation of human beta-glucuronidase.
Carcinoma, Hepatocellular
Isolation and characterization of the plasma membranes from rat ascites hepatomas and from normal rat livers, including newborn, regenerating, and adult livers.
Carcinoma, Hepatocellular
Membranous effects on adenosine triphosphatase activities of mitochondria from rat liver and Morris hepatoma 3924A.
Carcinoma, Hepatocellular
Mitochondrial adenosine triphosphatase of Zajdela hepatoma. III. Effect of uncouplers on the hydrolysis of intramitochondrial ATP.
Carcinoma, Hepatocellular
Mitochondrial ATPase of Zajdela hepatoma. II. Mitochondria of Zajdela hepatoma contain less adenosine triphosphatase than mitochondria of rat liver.
Carcinoma, Hepatocellular
Mitochondrial ATPase of Zajdela hepatoma. V. Mitochondria of Zajdela hepatoma contain membrane sectors of ATPase complex unassociated with F1.
Carcinoma, Hepatocellular
Mitochondrial ATPase of Zajdela hepatoma. VI. Effect of extramitochondrial ATP and pH on uncoupler-sensitivity of mitochondrial ATPase activity.
Carcinoma, Hepatocellular
Modification of the surface ATPase activity in cultured hepatoma cells by lipid-depleted media.
Carcinoma, Hepatocellular
Molecular determinants of nucleolar translocation of RNA helicase A.
Carcinoma, Hepatocellular
Obg-like ATPase 1 (OLA1) overexpression predicts poor prognosis and promotes tumor progression by regulating P21/CDK2 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Overexpression and role of the ATPase and putative DNA helicase RuvB-like 2 in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Oxidative phosphorylation enzymes in normal and neoplastic cell growth.
Carcinoma, Hepatocellular
Oxidative phosphorylation properties of mitochondria isolated from transplanted hepatoma.
Carcinoma, Hepatocellular
Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler.
Carcinoma, Hepatocellular
Prognostic significance of DNA topoisomerase IIalpha expression in human hepatocellular carcinoma. .
Carcinoma, Hepatocellular
Prognostic significance of sodium-potassium ATPase regulator, FXYD3, in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Purification and enzymological characterization of DNA-dependent ATPase IV from the Novikoff hepatoma.
Carcinoma, Hepatocellular
Quercetin-3-O-glucoside Induces Human DNA Topoisomerase II Inhibition, Cell Cycle Arrest and Apoptosis in Hepatocellular Carcinoma Cells.
Carcinoma, Hepatocellular
Reciprocal activation between ATPase inhibitory factor 1 and NF-?B drives hepatocellular carcinoma angiogenesis and metastasis.
Carcinoma, Hepatocellular
Regulation of human beta-glucuronidase by A23187 and thapsigargin in the hepatoma cell line HepG2.
Carcinoma, Hepatocellular
Some properties of coupled hepatoma mitochondria exhibiting uncoupler-insensitive ATPase activity.
Carcinoma, Hepatocellular
Studies on plasma membranes. VI. Differences in the effect of temperature on the ATPase and (Na+-K+)-ATPase activities of plasma membranes isolated from rat liver and hepatoma.
Carcinoma, Hepatocellular
Studies on plasma membranes. XII. Fractionation of the ATPase of deoxycholate-solubilized rat liver and hepatoma plasma membranes and the morphological appearance of the preparations.
Carcinoma, Hepatocellular
Surface ATPase activity at cell-cell contacts in hepatic parenchymal cells and in cAMP-treated hepatoma cells in monolayer culture.
Carcinoma, Hepatocellular
The ATPase activity of reptin is required for its effects on tumor cell growth and viability in hepatocellular carcinoma.
Carcinoma, Hepatocellular
The effect of the natural protein inhibitor on H+-ATPase hepatoma 22a mitochondria.
Carcinoma, Hepatocellular
The epidermal growth factor/cAMP-inducible ectoCa(2+)-ATPase of human hepatoma Li-7A cells is similar to rat liver ectoATPase/hepatocyte cell adhesion molecule (cell-CAM 105).
Carcinoma, Hepatocellular
The rat liver ecto-ATPase/C-CAM cDNA detects induction of carcinoembryonic antigen but not the mercurial-insensitive ecto-ATPase in human hepatoma Li-7A cells treated by epidermal growth factor and cholera toxin.
Carcinoma, Hepatocellular
TOP2A Amplification and Overexpression in Hepatocellular Carcinoma Tissues.
Carcinoma, Hepatocellular
TOP2A overexpression in hepatocellular carcinoma correlates with early age onset, shorter patients survival and chemoresistance.
Carcinoma, Hepatocellular
Toxic effects of copper-based antineoplastic drugs (Casiopeinas) on mitochondrial functions.
Carcinoma, Hepatocellular
XWL-1-48 exerts antitumor activity via targeting topoisomerase II and enhancing degradation of Mdm2 in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
[ATPase and AMPase activity in the mitochondria of two ascitic tumors: ascites hepatoma of the rat and Ehrlich ascites tumor.]
Carcinoma, Hepatocellular
[Electron-histochemical study of the ATPase activity in isolated cell nuclei of hepatomas]
Carcinoma, Hepatocellular
[Some peculiarities of ATPase in tumor mitochondria]
Carcinoma, Hepatocellular
[Study on ATPase of tumor cells--I. A comparison of several ATPase activities]
Carcinoma, Hepatocellular
[Ultrafine localization of the ATPase activity of plasma membrane cells in mice hepatomas]
Carcinoma, Intraductal, Noninfiltrating
Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women.
Carcinoma, Intraductal, Noninfiltrating
Amplification of growth regulatory genes in intraductal breast cancer is associated with higher nuclear grade but not with the progression to invasiveness.
Carcinoma, Intraductal, Noninfiltrating
Detection of gene amplification in intraductal and infiltrating breast cancer by laser-assisted microdissection and quantitative real-time PCR.
Carcinoma, Intraductal, Noninfiltrating
Interphase cytogenetic analysis of erbB2 and topoII alpha co-amplification in invasive breast cancer and polysomy of chromosome 17 in ductal carcinoma in situ.
Carcinoma, Intraductal, Noninfiltrating
Molecular differences between ductal carcinoma in situ and adjacent invasive breast carcinoma: A multiplex ligation-dependent probe amplification study.
Carcinoma, Intraductal, Noninfiltrating
Novel molecular markers of malignancy in histologically normal and benign breast.
Carcinoma, Intraductal, Noninfiltrating
Sharp Downregulation of Hub Genes Associated With the Pathogenesis of Breast Cancer From Ductal Carcinoma In Situ to Invasive Ductal Carcinoma.
Carcinoma, Intraductal, Noninfiltrating
Topoisomerase IIalpha expression in ductal carcinoma in situ of the breast: a preliminary study.
Carcinoma, Lewis Lung
A comparison of the effects of aphidicolin and other inhibitors on topoisomerase II-directed cytotoxic drugs.
Carcinoma, Lewis Lung
Dicationic bis(9-methylphenazine-1-carboxamides): relationships between biological activity and linker chain structure for a series of potent topoisomerase targeted anticancer drugs.
Carcinoma, Lewis Lung
Novel carbamate analogues of amsacrine with activity against non-cycling murine and human tumour cells.
Carcinoma, Lewis Lung
Relationship of cell cycle parameters to in vitro and in vivo chemosensitivity for a series of Lewis lung carcinoma lines.
Carcinoma, Medullary
Renal medullary carcinoma: molecular, pathological and clinical evidence for treatment with topoisomerase-inhibiting therapy.
Carcinoma, Medullary
Topoisomerase II alpha status in renal medullary carcinoma: immuno-expression and gene copy alterations of a potential target of therapy.
Carcinoma, Merkel Cell
Oral etoposide for Merkel cell carcinoma in patients previously treated with intravenous etoposide.
Carcinoma, Non-Small-Cell Lung
17-(Allylamino)-17-Demethoxygeldanamycin Enhances Etoposide-Induced Cytotoxicity via the Downregulation of Xeroderma Pigmentosum Complementation Group C Expression in Human Lung Squamous Cell Carcinoma Cells.
Carcinoma, Non-Small-Cell Lung
Alternative polyadenylation is associated with lower expression of PABPN1 and poor prognosis in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Amplification of the topoisomerase II alpha gene in a non-small cell lung cancer cell line and characterisation of polymorphisms at the human topoisomerase II alpha and beta loci in normal tissue.
Carcinoma, Non-Small-Cell Lung
Association between clinical pathology and multiple genes mRNA expression in Chinese patients with NSCLC.
Carcinoma, Non-Small-Cell Lung
Association of Topoisomerase II (TOP2A) and Dual-Specificity Phosphatase 6 (DUSP6) Single Nucleotide Polymorphisms with Radiation Treatment Response and Prognosis of Lung Cancer in Han Chinese.
Carcinoma, Non-Small-Cell Lung
ATPase inhibitory factor 1 expression is an independent prognostic factor in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Cell proliferation and apoptosis in stage III inoperable non-small cell lung carcinoma treated by radiotherapy.
Carcinoma, Non-Small-Cell Lung
Clinical significance of topoisomerase-II expression in patients with advanced non-small cell lung cancer treated with amrubicin.
Carcinoma, Non-Small-Cell Lung
Differential expression of DNA topoisomerase II alpha and II beta genes between small cell and non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
E-M, an Engineered Endostatin with High ATPase Activity, Inhibits the Recruitment and Alternative Activation of Macrophages in Non-small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Effect of TOP2A and ERCC1 gene polymorphisms on the efficacy and toxicity of cisplatin and etoposide-based chemotherapy in small cell lung cancer patients.
Carcinoma, Non-Small-Cell Lung
Gene Silencing Associated with SWI/SNF Complex Loss during NSCLC Development.
Carcinoma, Non-Small-Cell Lung
Multidrug resistance protein and topoisomerase 2 alpha expression in non-small cell lung cancer are related with brain metastasis postoperatively.
Carcinoma, Non-Small-Cell Lung
Multidrug sensitivity phenotype of human lung cancer cells associated with topoisomerase II expression.
Carcinoma, Non-Small-Cell Lung
Prognostic significance of TOP2A in non-small cell lung cancer revealed by bioinformatic analysis.
Carcinoma, Non-Small-Cell Lung
Promoter polymorphisms of TOP2A and ERCC1 genes as predictive factors for chemotherapy in non-small cell lung cancer patients.
Carcinoma, Non-Small-Cell Lung
Reduced topoisomerase II activity in multidrug-resistant human non-small cell lung cancer cell lines.
Carcinoma, Non-Small-Cell Lung
RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer.
Carcinoma, Non-Small-Cell Lung
The expression of V-ATPase is associated with drug resistance and pathology of non-small-cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Topoisomerase II alpha expression and the benefit of adjuvant chemotherapy for postoperative patients with non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Topoisomerase IIalpha and other drug resistance markers in advanced non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Tyrosine kinase inhibitors potentiate the cytotoxicity of MDR-substrate anticancer agents independent of growth factor receptor status in lung cancer cell lines.
Carcinoma, Non-Small-Cell Lung
[Expression of multiple drug resistance-associated proteins in non-small cell lung cancer tissues and its clinical significance.]
Carcinoma, Ovarian Epithelial
Effect of recombinant human tumor necrosis factor on A2774 human ovarian cancer cell line: potentiation of mitoxantrone cytotoxicity.
Carcinoma, Ovarian Epithelial
Enhanced topoisomerase I activity and increased topoisomerase II alpha content in cisplatin-resistant cancer cell lines.
Carcinoma, Ovarian Epithelial
Immunohistochemical and two-parameter flow cytometric studies of DNA topoisomerase II alpha in human epithelial ovarian carcinoma and germ cell tumor.
Carcinoma, Ovarian Epithelial
Synergistic cytotoxic effects of recombinant human tumor necrosis factor and Etoposide (VP16) or Doxorubicin on A2774 human epithelial ovarian cancer cell line.
Carcinoma, Ovarian Epithelial
The potential mechanism of chemosensitive difference between 2 types of ovarian cancer.
Carcinoma, Ovarian Epithelial
TOP2A as marker of response to pegylated lyposomal doxorubicin (PLD) in epithelial ovarian cancers.
Carcinoma, Ovarian Epithelial
TOP2A gene copy gain predicts response of epithelial ovarian cancers to pegylated liposomal doxorubicin: TOP2A as marker of response to PLD in ovarian cancer.
Carcinoma, Ovarian Epithelial
Topoisomerase II immunostaining as a prognostic marker for survival in ovarian cancer.
Carcinoma, Ovarian Epithelial
[Inhibition of Topo II alpha gene expression and reversing of drug resistance in multi-drug resistant epithelial ovarian cancer cells induced by RNA interference in vitro]
Carcinoma, Ovarian Epithelial
[The expression of MRP, GST-pi, Topo IIalpha and COX-2 in epithelial ovarian cancer and its relationship to drug resistance and prognosis]
Carcinoma, Papillary
p27kip1 expression distinguishes papillary hyperplasia in Graves' disease from papillary thyroid carcinoma.
Carcinoma, Renal Cell
15-Deoxy-?12,14-prostaglandin J2 enhanced the anti-tumor activity of camptothecin against renal cell carcinoma independently of topoisomerase-II and PPAR? pathways.
Carcinoma, Renal Cell
A phase II study of razoxane, an antiangiogenic topoisomerase II inhibitor, in renal cell cancer with assessment of potential surrogate markers of angiogenesis.
Carcinoma, Renal Cell
Decreased levels of topoisomerase II alpha in human renal cell carcinoma lines resistant to etoposide.
Carcinoma, Renal Cell
Expression of genes involved in chemoresistance, proliferation and apoptosis in clinical samples of renal cell carcinoma and correlation with clinical outcome.
Carcinoma, Renal Cell
Expression of resistance factors (P-glycoprotein, glutathione S-transferase-pi, and topoisomerase II) and their interrelationship to proto-oncogene products in renal cell carcinomas.
Carcinoma, Renal Cell
Expression of several resistance mechanisms in untreated human kidney and lung carcinomas.
Carcinoma, Renal Cell
Expression patterns of multidrug-resistance (MDR1), multidrug resistance-associated protein (MRP),glutathione-S-transferase-pi (GST-pi) and DNA topoisomerase II (Topo II) genes in renal cell carcinomas and normal kidney.
Carcinoma, Renal Cell
Higher Expression of Topoisomerase II Alpha Is an Independent Marker of Increased Risk of Cancer-specific Death in Patients with Clear Cell Renal Cell Carcinoma.
Carcinoma, Renal Cell
Identifying a Novel Biomarker TOP2A of Clear Cell Renal Cell Carcinoma (ccRCC) Associated with Smoking by Co-Expression Network Analysis.
Carcinoma, Renal Cell
LncRNA SNHG3 promotes clear cell renal cell carcinoma proliferation and migration by upregulating TOP2A.
Carcinoma, Renal Cell
NPRL-Z-1, as a new topoisomerase II poison, induces cell apoptosis and ROS generation in human renal carcinoma cells.
Carcinoma, Renal Cell
The activity of topoisomerases is related to the grade and stage in human renal cell carcinoma.
Carcinoma, Renal Cell
TOP2A, HELLS, ATAD2, and TET3 Are Novel Prognostic Markers in Renal Cell Carcinoma.
Carcinoma, Renal Cell
[Secondary TFE3-associated renal cell carcinoma in a child treated for Ewing sarcoma].
Carcinoma, Small Cell
Genomic landscape of small cell carcinoma of the breast contrasted to small cell carcinoma of the lung.
Carcinoma, Small Cell
Isolation and characterization of plasma membranes from transplantable human astrocytoma, oat cell carcinoma, and melanomas.
Carcinoma, Small Cell
Oxidative phosphorylation and ATPase activities of human tumor mitochondria.
Carcinoma, Small Cell
The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex identity and catalytic activity-independent genomic targeting.
Carcinoma, Small Cell
The common occurrence of ATP diphosphohydrolase in mammalian plasma membranes.
Carcinoma, Small Cell
The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancer.
Carcinoma, Squamous Cell
Ammonium tetrathiomolybdate enhances the antitumor effect of cisplatin via the suppression of ATPase copper transporting beta in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Detecting high-grade cervical disease on ASC-H cytology: role of BD ProEx C and Digene Hybrid Capture II HPV DNA testing.
Carcinoma, Squamous Cell
DNA topoisomerase I and IIalpha expression in penile carcinomas: assessing potential tumour chemosensitivity.
Carcinoma, Squamous Cell
Dual-specificity phosphatase 6 genetic variants associated with risk of lung squamous cell carcinoma in Han Chinese.
Carcinoma, Squamous Cell
Effect of retinoic acid on DNA cleavage and cytotoxicity of topoisomerase II-reactive drugs in a human head and neck squamous carcinoma cell line.
Carcinoma, Squamous Cell
Epidermal growth factor induction of resistance to topoisomerase II toxins in human squamous carcinoma A431 cells.
Carcinoma, Squamous Cell
Expression of drug resistance-related genes in head and neck squamous cell carcinomas and normal mucosa.
Carcinoma, Squamous Cell
Expression of topoisomerase II and Ki-67 in cervical carcinoma--clinicopathological study using immunohistochemistry.
Carcinoma, Squamous Cell
Expression of topoisomerase IIalpha, Ki-67, proliferating cell nuclear antigen, p53, and argyrophilic nucleolar organizer regions in vulvar squamous lesions.
Carcinoma, Squamous Cell
Identification of tumor-associated antigens of lung cancer: SEREX combined with bioinformatics analysis.
Carcinoma, Squamous Cell
Lymphocyte ATPase activity in patients with carcinoma of the larynx. A follow-up study on 45 patients.
Carcinoma, Squamous Cell
MicroRNAs contribute to the chemoresistance of cisplatin in tongue squamous cell carcinoma lines.
Carcinoma, Squamous Cell
Mining expression and prognosis of topoisomerase isoforms in non-small-cell lung cancer by using Oncomine and Kaplan-Meier plotter.
Carcinoma, Squamous Cell
Over-Expression of Topoisomerase IIalpha is Related to the Grade of Cervical Intraepithelial Neoplasia (CIN) and High-Risk Human Papillomavirus (HPV), but does not Predict Prognosis in Cervical Cancer or HPV Clearance after Cone Treatment.
Carcinoma, Squamous Cell
The prognostic significance of proliferative activity, apoptosis and expression of DNA topoisomerase II alpha in multimodally-treated oesophageal squamous cell carcinoma.
Carcinoma, Squamous Cell
Topoisomerase II alpha expression in squamous cell carcinomas of the head and neck.
Carcinoma, Squamous Cell
Topoisomerase IIalpha gene expression is regulated by the p53 tumor suppressor gene in nonsmall cell lung carcinoma patients.
Carcinoma, Squamous Cell
[Expression and implication of Pgp, MRP, LRP, GST-pi, Topo II alpha in tongue squamous cell carcinoma]
Carcinoma, Squamous Cell
[Study on the relationship among multidrug resistance factor expression of lung cancer tissues and clinicopathological characteristics in patients with lung cancer.]
Carcinoma, Transitional Cell
Protein expression and gene copy number analysis of topoisomerase 2alpha, HER2 and P53 in minimally invasive urothelial carcinoma of the urinary bladder--a multitissue array study with prognostic implications.
Carcinoma, Verrucous
DNA topoisomerase I and IIalpha expression in penile carcinomas: assessing potential tumour chemosensitivity.
Cardiac Output, Low
Combining SERCA2a activation and Na-K ATPase inhibition: a promising new approach to managing acute heart failure syndromes with low cardiac output.
Cardiomegaly
Abnormal contractile function in transgenic mice expressing a familial hypertrophic cardiomyopathy-linked troponin T (I79N) mutation.
Cardiomegaly
ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKII?.
Cardiomegaly
Canine cardiac myosin with special reference to pressure overload cardiac hypertrophy. II. Myosin ATPase.
Cardiomegaly
Cardiac adaptations to chronic exercise in mice.
Cardiomegaly
Cardiac myosin: preparation, ATPase in chronic heart hypertrophy.
Cardiomegaly
Catecholamine-induced cardiovascular disease in the spontaneously hypertensive and atherosclerotic turkey.
Cardiomegaly
Changes in rat ventricular isomyosins with regression of cardiac hypertrophy.
Cardiomegaly
Characterization of the decreased ATPase activity of rat cardiac actomyosin in isoproterenol-induced cardiac hypertrophy.
Cardiomegaly
Effects of triiodo-thyronine on angiotensin-induced cardiomyocyte hypertrophy: reversal of increased beta-myosin heavy chain gene expression.
Cardiomegaly
Investigating the relaxation, following diazo-2 laser flash photolysis, of a skinned trabecular preparation from SHR hypertrophied left ventricle.
Cardiomegaly
Knockout of the ATPase inhibitory factor 1 protects the heart from pressure overload-induced cardiac hypertrophy.
Cardiomegaly
Major alterations in relaxation during cardiac hypertrophy induced by aortic stenosis in guinea pig.
Cardiomegaly
Modification of subcellular organelles in pressure-overloaded heart by etomoxir, a carnitine palmitoyltransferase I inhibitor.
Cardiomegaly
Myocardial Ca-sequestration failure and compensatory increase in Ca-ATPase with congestive cardiomyopathy: kinetic characterization by a homogenate microassay using real-time ratiometric indo-1 spectrofluorometry.
Cardiomegaly
Myosin isoenzymes of vascular smooth and cardiac muscle in the spontaneously hypertensive and normotensive male and female rat: a comparative study.
Cardiomegaly
Peculiarities of adaptation to systematic muscular activity in adrenalectomized rats.
Cardiomegaly
Progression and regression of cardiac hypertrophy in hypertensive rats: biochemical and molecular changes in ventricular myosin.
Cardiomegaly
Subcellular remodeling and heart dysfunction in cardiac hypertrophy due to pressure overload.
Cardiomegaly
Sucrose feeding prevents changes in myosin isoenzymes and sarcoplasmic reticulum Ca2+-pump ATPase in pressure-loaded rat heart.
Cardiomegaly
The effects of intracellular Ca2+ on cardiac K+ channel expression and activity: novel insights from genetically altered mice.
Cardiomegaly
The relationship of a decline in myofibrillar ATP-ase activity to the development of severe left ventricular hypertrophy in the rat.
Cardiomegaly
Ventricular myosin pattern of spontaneously hypertensive turkeys is unaffected by labetalol treatment.
Cardiomegaly
[Changes in the activity of Ca2+ stimulated membrane ATPase and calcium binding in the myocardium in cardiac hypertrophy in rats induced by catecholamines]
Cardiomegaly
[Participation of glucocorticoids in development and provisions for work capacity]
Cardiomyopathies
Abnormalities in heart membranes and myofibrils during bacterial infective cardiomyopathy in the rabbit.
Cardiomyopathies
Analysis of gene expression patterns in small amounts of human ventricular myocardium by a multiplex RNase protection assay.
Cardiomyopathies
Changes in the expression of cardiac Na+-K+ ATPase subunits in the UM-X7.1 cardiomyopathic hamster.
Cardiomyopathies
Congenital myopathy with mosaic fibers and interlacing sarcomeres: a new structural myopathy.
Cardiomyopathies
Hypoxic right ventricular cardiomyopathy. A morphological and pathogenetic study on the myocardial atrophy and fatty infiltration.
Cardiomyopathies
In vitro selection and characterization of DNA aptamers specific for phospholamban.
Cardiomyopathies
Inherited cardiomyopathies caused by troponin mutations.
Cardiomyopathies
Mechanical unloading improves intracellular Ca2+ regulation in rats with doxorubicin-induced cardiomyopathy.
Cardiomyopathies
Modulation of cross-bridge interaction by 2,3-butanedione monoxime in human ventricular myocardium.
Cardiomyopathies
Molecular insights into uremic cardiomyopathy: cardiotonic steroids and na/k ATPase signaling.
Cardiomyopathies
Myocardial Ca-sequestration failure and compensatory increase in Ca-ATPase with congestive cardiomyopathy: kinetic characterization by a homogenate microassay using real-time ratiometric indo-1 spectrofluorometry.
Cardiomyopathies
Myofibrillar ATPase in catecholamine induced myocardiopathy in rhesus monkeys.
Cardiomyopathies
OXIDATIVE STRESS IN CARDIOMYOCYTES CONTRIBUTES TO DECREASED SERCA2a ACTIVITY IN METABOLIC SYNDROME RATS.
Cardiomyopathies
Phosphorylation status of regulatory proteins and functional characteristics in myocardium of dilated cardiomyopathy of Syrian hamsters.
Cardiomyopathies
Rapidly progressive infantile cardiomyopathy with mitochondrial respiratory chain complex V deficiency due to loss of ATPase 6 and 8 protein.
Cardiomyopathies
Sarcolemmal Na+-Ca2+ exchange and Ca2+-pump activities in cardiomyopathies due to intracellular Ca2+-overload.
Cardiomyopathy, Dilated
Alterations of sarcoplasmic reticulum proteins in failing human dilated cardiomyopathy.
Cardiomyopathy, Dilated
Cellular and molecular remodeling in a heart failure model treated with the beta-blocker carteolol.
Cardiomyopathy, Dilated
Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy.
Cardiomyopathy, Dilated
Dilated cardiomyopathy mutations in alpha-tropomyosin inhibit its movement during the ATPase cycle.
Cardiomyopathy, Dilated
Early and late effects of cardiac resynchronization therapy on force-frequency relation and contractility regulating gene expression in heart failure patients.
Cardiomyopathy, Dilated
Human myocardial adenosine triphosphatase activities in health and heart failure.
Cardiomyopathy, Dilated
Immunohistochemical evidence for expression of fast-twitch type sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA1) in German shepherd dogs with dilated cardiomyopathy myocardium.
Cardiomyopathy, Dilated
The idiopathic dilated cardiomyopathy in man. A biochemical and molecular study on myosin.
Cardiomyopathy, Dilated
The troponin C G159D mutation blunts myofilament desensitization induced by troponin I Ser23/24 phosphorylation.
Cardiomyopathy, Dilated
[Abnormal tropomyosin function in ATPase cycle in hypertrophic and dilated cardiomyopathies].
Cardiomyopathy, Dilated
[Changes in composition of cardiac myosin light chains in dilated cardiomyopathy: effect on functional properties]
Cardiomyopathy, Dilated
[Correlation of intra-erythrocytic Na, K, Ca, Mg contents and ATPase activity with dilated cardiomyopathy]
Cardiomyopathy, Dilated
[Genetic complementation studies using genetically engineered mice have revealed the impact of phospholamban on progression of cardiomyopathy]
Cardiomyopathy, Hypertrophic
Computational simulation of hypertrophic cardiomyopathy mutations in troponin I: influence of increased myofilament calcium sensitivity on isometric force, ATPase and [Ca2+]i.
Cardiomyopathy, Hypertrophic
Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human ?-Cardiac Myosin.
Cardiomyopathy, Hypertrophic
Mitochondrial Energetics and Ca2+-Activated ATPase in Obstructive Hypertrophic Cardiomyopathy.
Cardiomyopathy, Hypertrophic
Mutations in human cardiac troponin I that are associated with restrictive cardiomyopathy affect basal ATPase activity and the calcium sensitivity of force development.
Cardiomyopathy, Hypertrophic, Familial
Ca2+ sensitization and potentiation of the maximum level of myofibrillar ATPase activity caused by mutations of troponin T found in familial hypertrophic cardiomyopathy.
Cardiomyopathy, Hypertrophic, Familial
Confirmation of Cause and Manner of Death Via a Comprehensive Cardiac Autopsy Including Whole Exome Next-Generation Sequencing.
Cardiomyopathy, Hypertrophic, Familial
Effect of Arg145Gly mutation in human cardiac troponin I on the ATPase activity of cardiac myofibrils.
Cardiomyopathy, Hypertrophic, Familial
Functional analysis of myosin mutations that cause familial hypertrophic cardiomyopathy.
Cardiomyopathy, Hypertrophic, Familial
The Delta 14 mutation of human cardiac troponin T enhances ATPase activity and alters the cooperative binding of S1-ADP to regulated actin.
Cardiomyopathy, Hypertrophic, Familial
The E22K mutation of myosin RLC that causes familial hypertrophic cardiomyopathy increases calcium sensitivity of force and ATPase in transgenic mice.
Cardiomyopathy, Restrictive
Mutations in human cardiac troponin I that are associated with restrictive cardiomyopathy affect basal ATPase activity and the calcium sensitivity of force development.
Cardiotoxicity
A "Double-Edged" Scaffold: Antitumor Power within the Antibacterial Quinolone.
Cardiotoxicity
A Series of Novel HDAC Inhibitors with Anthraquinone as a Cap Group.
Cardiotoxicity
Anthracyclines and mitochondria.
Cardiotoxicity
Caffeic Acid Protects against Iron-Induced Cardiotoxicity by Suppressing Angiotensin-Converting Enzyme Activity and Modulating Lipid Spectrum, Gluconeogenesis and Nucleotide Hydrolyzing Enzyme Activities.
Cardiotoxicity
Cellular resistance against the novel hybrid anthracycline N-(2-chloroethyl)-N-nitrosoureidodaunorubicin (AD 312) is mediated by combined altered topoisomerase II and O6-methylguanine-DNA methyltransferase activities.
Cardiotoxicity
Comparative analysis of stress responses of H9c2 rat cardiomyoblasts following treatment with doxorubicin and tBOOH.
Cardiotoxicity
Cytotoxicity and intracellular biotransformation of N-benzyladriamycin-14-valerate (AD 198) are modulated by changes in 14-O-acyl chain length.
Cardiotoxicity
Design and synthesis of 3,5-substituted 1,2,4-oxadiazoles as catalytic inhibitors of human DNA topoisomerase II?.
Cardiotoxicity
Development of acridine derivatives as selective Mycobacterium tuberculosis DNA gyrase inhibitors.
Cardiotoxicity
Diminished molecular response to doxorubicin and loss of cardioprotective effect of dexrazoxane in Egr-1 deficient female mice.
Cardiotoxicity
Discovery of New Catalytic Topoisomerase II Inhibitors for Anticancer Therapeutics.
Cardiotoxicity
Emerging DNA topisomerase inhibitors as anticancer drugs.
Cardiotoxicity
Evidence for association of SNPs in ABCB1 and CBR3, but not RAC2, NCF4, SLC28A3 or TOP2B, with chronic cardiotoxicity in a cohort of breast cancer patients treated with anthracyclines.
Cardiotoxicity
Heart Failure in Relation to Anthracyclines and Other Chemotherapies.
Cardiotoxicity
Identification of the molecular basis of doxorubicin-induced cardiotoxicity.
Cardiotoxicity
Intercalating TOP2 Poisons Attenuate Topoisomerase Action at Higher Concentrations.
Cardiotoxicity
Investigation of Structure-Activity Relationships of Dexrazoxane Analogs Reveals Topoisomerase II? Interaction as a Prerequisite for Effective Protection against Anthracycline Cardiotoxicity.
Cardiotoxicity
Mechanisms and Potential Treatment Options of Heart Failure in Patients With Multiple Myeloma.
Cardiotoxicity
Mechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase II? Isoform.
Cardiotoxicity
Mechanisms of anthracycline-mediated cardiotoxicity and preventative strategies in women with breast cancer.
Cardiotoxicity
Mechanisms of toxic cardiomyopathy.
Cardiotoxicity
Monocyclic Quinone Structure-Activity Patterns: Synthesis of Catalytic Inhibitors of Topoisomerase II with Potent Antiproliferative Activity.
Cardiotoxicity
Neonatal murine engineered cardiac tissue toxicology model: Impact of dexrazoxane on doxorubicin induced injury.
Cardiotoxicity
Potential Therapeutic Advantages of Doxorubicin when Activated by Formaldehyde to Function as a DNA Adduct-Forming Agent.
Cardiotoxicity
Protective effects of dietary selenium and vitamin C in barium-induced cardiotoxicity.
Cardiotoxicity
Reduction of myofibrillar ATPase activity and isomyosin shift in delayed doxorubicin cardiotoxicity.
Cardiotoxicity
Sarcoendoplasmic reticulum Ca(2+) ATPase. A critical target in chlorine inhalation-induced cardiotoxicity.
Cardiotoxicity
Structure-guided optimization of 4,6-substituted-1,3,5-triazin-2(1H)-ones as catalytic inhibitors of human DNA topoisomerase II?.
Cardiotoxicity
Substituted 4,5'-Bithiazoles as Catalytic Inhibitors of Human DNA Topoisomerase II?.
Cardiotoxicity
Targeting ?2 subunit of Na+/K+-ATPase induces glioblastoma cell apoptosis through elevation of intracellular Ca2.
Cardiotoxicity
The cardioprotective and DNA topoisomerase II inhibitory agent dexrazoxane (ICRF-187) antagonizes camptothecin-mediated growth inhibition of Chinese hamster ovary cells by inhibition of DNA synthesis.
Cardiotoxicity
The chemopreventive potential of lycopene against atrazine-induced cardiotoxicity: modulation of ionic homeostasis.
Cardiotoxicity
The doxorubicin cardioprotective agent dexrazoxane (ICRF-187) induces endopolyploidy in rat neonatal myocytes through inhibition of DNA topoisomerase II.
Cardiotoxicity
The one-ring open hydrolysis intermediates of the cardioprotective agent dexrazoxane (ICRF-187) do not inhibit the growth of Chinese hamster ovary cells or the catalytic activity of DNA topoisomerase II.
Cardiotoxicity
Topoisomerase IIbeta mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane.
Cardiotoxicity
Type IIB DNA topoisomerase is downregulated by trastuzumab and doxorubicin to synergize cardiotoxicity.
Cardiotoxicity
Uncoupling DNA damage from chromatin damage to detoxify doxorubicin.
Cardiotoxicity
WRC-213, an l-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers.
Cardiotoxicity
[Anthracycline-induced cardiotoxicity]
Cardiovascular Abnormalities
Molecular aspects of cardiac hypertrophy.
Cardiovascular Diseases
Cardiovascular drugs in human mechanical nociception: digoxin, amlodipine, propranolol, pindolol and atenolol.
Cardiovascular Diseases
Digoxin cannot account for the reported association of EKG abnormalities and rhegmatogenous retinal detachment.
Cardiovascular Diseases
[Enzymatic activity of arterial vessels of the human kidney in the norm and various cardiovascular diseases]
Cataract
Changes in mitochondrial cytochrome c oxidase mRNA levels with cataract severity in lens epithelia of Japanese patients.
Cataract
Dysfunction in Cytochrome c Oxidase Caused by Excessive Nitric Oxide in Human Lens Epithelial Cells Stimulated with Interferon-? and Lipopolysaccharide.
Cataract
Investigations on rat eyes with diabetic cataract and naphthalene cataract by Zeiss-Scheimpflug measuring system SLC.
Cataract
Lupeol, a pentacyclic triterpenoid isolated from Vernonia cinerea attenuate selenite induced cataract formation in Sprague Dawley rat pups.
Cataract
Menadione-induced oxidative stress accelerates onset of Emory mouse cataract in vivo.
Cataract
Olmesartan, an angiotensin II receptor blocker inhibits the progression of cataract formation in cadmium chloride induced hypertensive albino rats.
Cataract
Penetration of ciprofloxacin, norfloxacin and ofloxacin into the aqueous humor using different topical application modes.
Cataract
Sodium-potassium--dependent ATPase. II. Cytochemical localization during the reversal of galactose cataracts in rat.
Cataract
Sodium-potassium-dependent ATPase. III. Cytochemical localization during the reversal of in utero induced galactose cataracts in rat.
Cataract
Sodium/potassium ATPase in normal and cataractous human lenses.
Cataract
State of electrolytes, osmotic balance and the activity of ATPase in the lenses of selenite--induced cataracts.
Cataract
The evaluation of therapeutic efficacy of hachimi-jio-gan (traditional Chinese medicine) to mouse hereditary cataract.
Cataract
Tissue culture of lens epithelial cells from normal and Nakano mice.
Cataract
Variations in ATPase activity in the development of experimental cataracts.
Cataract
[Anti-cataract activity of a vitamin E analog]
Cataract
[Behavior of membrane ATPase involved in hereditary cataract formation. A preliminenary report]
Celiac Disease
Alterations in quantitative distribution of Na,K-ATPase activity along crypt-villus axis in animal model of malabsorption characterized by hyperproliferative crypt cytokinetics.
Cell Transformation, Neoplastic
Transformation and pH homeostasis of fibroblasts expressing yeast H(+)-ATPase containing site-directed mutations.
Central Nervous System Diseases
Glial Na(+) -dependent ion transporters in pathophysiological conditions.
Cerebellar Ataxia
Marked inhibition of Na+, K(+)- ATPase activity and the respiratory chain by phytanic acid in cerebellum from young rats: possible underlying mechanisms of cerebellar ataxia in Refsum disease.
Cerebellar Ataxia
Stiff person syndrome and other immune-mediated movement disorders - new insights.
Cervical Intraepithelial Neoplasia
Expression of topoisomerase II and Ki-67 in cervical carcinoma--clinicopathological study using immunohistochemistry.
Cervical Intraepithelial Neoplasia
Over-Expression of Topoisomerase IIalpha is Related to the Grade of Cervical Intraepithelial Neoplasia (CIN) and High-Risk Human Papillomavirus (HPV), but does not Predict Prognosis in Cervical Cancer or HPV Clearance after Cone Treatment.
Cervical Intraepithelial Neoplasia
Subpopulations of Langerhans' cells in cervical neoplasia.
Chagas Disease
Divalent metal requirements for catalysis and stability of the RNA triphosphatase from Trypanosoma cruzi.
CHARGE Syndrome
Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes.
Chikungunya Fever
Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus Infection.
Cholangiocarcinoma
Induction of apoptosis in cholangiocarcinoma by an andrographolide analogue is mediated through topoisomerase II alpha inhibition.
Cholecystitis
[Comparative characteristics of adenosine triphosphatase activity in the erythrocytes of patients with acute and chronic liver diseases, chronic cholecystitis and in HBs antigen carriers]
Cholera
Characterization of Vibrio cholerae O1 strains that trace the origin of Haitian-like genetic traits.
Cholera
Effect of cholera toxin on ATPase activities in rabbit small intestinal mucosa.
Cholera
Genetic traits of Vibrio cholerae O1 Haitian isolates that are absent in contemporary strains from Kolkata, India.
Cholera
Oligomerization of EpsE Coordinates Residues from Multiple Subunits to Facilitate ATPase Activity.
Cholera
Protein disulfide isomerase acts as a redox-dependent chaperone to unfold cholera toxin.
Cholera
Vibrio cholerae ParE2 poisons DNA gyrase via a mechanism distinct from other gyrase inhibitors.
Cholera
[Biochemical and immunochemical characteristics of a new oral, chemical cholera bivalent vaccine and results of a trial of the preparation on volunteers]
Cholestasis
Effects of chlorpromazine hydrochloride and its metabolites on Mg2+- and Na+,K+-ATPase activities of canalicular-enriched rat liver plasma membranes.
Cholestasis
Phospholipase D2 mediates signaling by ATPase class I type 8B membrane 1.
Cholestasis
Properties of (Na+ plus K+)-activated ATPase in rat liver plasma membranes enriched with bile canaliculi.
Cholestasis
The ectopic F(O)F(1) ATP synthase of rat liver is modulated in acute cholestasis by the inhibitor protein IF1.
Cholestasis, Intrahepatic
Impact of Genotype, Serum Bile Acids, and Surgical Biliary Diversion on Native Liver Survival in FIC1 Deficiency.
Cholestasis, Intrahepatic
Phospholipase D2 mediates signaling by ATPase class I type 8B membrane 1.
Cholestasis, Intrahepatic
Sequencing of FIC1, BSEP and MDR3 in a large cohort of patients with cholestasis revealed a high number of different genetic variants.
Cholestasis, Intrahepatic
The lipid flippase heterodimer ATP8B1-CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells.
Cholestasis, Intrahepatic
The membrane protein ATPase class I type 8B member 1 signals through protein kinase C zeta to activate the farnesoid X receptor.
Cholestasis, Intrahepatic
[ATPase activity of erythrocytic membrane and intraerythrocytic ionic levels in pregnancy with intrahepatic cholestasis]
Cholestasis, Intrahepatic
[Electron optical and enzyme histo- chemical demonstration of ATPase recognizable changes in the rat liver in experimental intrahepatic cholestasis]
Choline Deficiency
Carnitine modulates crucial myocardial adenosine triphosphatases and acetylcholinesterase enzyme activities in choline-deprived rats.
Chondrosarcoma
Histone deacetylase inhibitors vorinostat and panobinostat induce G1 cell cycle arrest and apoptosis in multidrug resistant sarcoma cell lines.
Chorea
Stiff person syndrome and other immune-mediated movement disorders - new insights.
Choriocarcinoma
Topoisomerase II alpha expression in testicular germ cell tumors.
Chronic Periodontitis
[The ATPase content of the blood neutrophils and lymphocytes in patients with chronic periodontitis]
Cockayne Syndrome
Differential requirement for the ATPase domain of the Cockayne syndrome group B gene in the processing of UV-induced DNA damage and 8-oxoguanine lesions in human cells.
Cockayne Syndrome
Mechanistic insights into the regulation of transcription and transcription-coupled DNA repair by Cockayne syndrome protein B.
Cockayne Syndrome
Rad26p, a transcription-coupled repair factor, is recruited to the site of DNA lesion in an elongating RNA polymerase II-dependent manner in vivo.
Cockayne Syndrome
Regulatory interplay of Cockayne syndrome B ATPase and stress-response gene ATF3 following genotoxic stress.
Cockayne Syndrome
Role of the ATPase domain of the Cockayne syndrome group B protein in UV induced apoptosis.
Cockayne Syndrome
The ATPase domain but not the acidic region of Cockayne syndrome group B gene product is essential for DNA repair.
Cockayne Syndrome
The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells.
Colitis
Inhibition of N-terminal ATPase on HSP90 attenuates colitis through enhanced Treg function.
Colitis
[Ulcerative colitis caused by oral gold therapy in rheumatoid arthritis]
Colonic Neoplasms
A novel use for the comet assay: detection of topoisomerase II inhibitors.
Colonic Neoplasms
Bioinformatics Analysis of Prognostic miRNA Signature and Potential Critical Genes in Colon Cancer.
Colonic Neoplasms
Differential GADD45, p21CIP1/WAF1, MCL-1 and topoisomerase II gene induction and secondary DNA fragmentation after camptothecin-induced DNA damage in two mutant p53 human colon cancer cell lines.
Colonic Neoplasms
DNA break mapping reveals topoisomerase II activity genome-wide.
Colonic Neoplasms
DNA damage response to the Mdm2 inhibitor Nutlin-3.
Colonic Neoplasms
Doxazolidine induction of apoptosis by a topoisomerase II independent mechanism.
Colonic Neoplasms
Effect of acute and chronic intermittent hypoxia on DNA topoisomerase II alpha expression and mitomycin C-induced DNA damage and cytotoxicity in human colon cancer cells.
Colonic Neoplasms
Effects of ER-37328 on primary tumor, liver metastasis, and life span in a murine colon 38 orthotopic transplantation model.
Colonic Neoplasms
Endoplasmic reticulum calcium transport ATPase expression during differentiation of colon cancer and leukaemia cells.
Colonic Neoplasms
Enhanced coexpression of YB-1 and DNA topoisomerase II alpha genes in human colorectal carcinomas.
Colonic Neoplasms
Expression and relationship between topoisomerase I and II alpha genes in tumor and normal tissues in esophageal, gastric and colon cancers.
Colonic Neoplasms
Expression, regulation and clinical relevance of the ATPase inhibitory factor 1 in human cancers.
Colonic Neoplasms
Factors contributing to adriamycin sensitivity in human xenograft tumors: the relationship between expression of the MDR1, GST-pi and topoisomerase II genes and tumor sensitivity to adriamycin.
Colonic Neoplasms
Genistein induces apoptosis and topoisomerase II-mediated DNA breakage in colon cancer cells.
Colonic Neoplasms
Glucose-regulated stresses cause degradation of DNA topoisomerase IIalpha by inducing nuclear proteasome during G1 cell cycle arrest in cancer cells.
Colonic Neoplasms
Glucose-regulated stresses confer resistance to VP-16 in human cancer cells through a decreased expression of DNA topoisomerase II.
Colonic Neoplasms
Homocamptothecin, an E-ring-modified camptothecin, exerts more potent antiproliferative activity than other topoisomerase I inhibitors in human colon cancers obtained from surgery and maintained in vitro under histotypical culture conditions.
Colonic Neoplasms
Identification of Tumor Antigen AF20 as Glycosylated Transferrin Receptor 1 in Complex with Heat Shock Protein 90 and/or Transporting ATPase.
Colonic Neoplasms
Induction of apoptosis in colon cancer cells by a novel topoisomerase I inhibitor TopIn.
Colonic Neoplasms
Inhibition of heat shock proteins increases autophagosome formation, and reduces the expression of APP, Tau, SOD1 G93A and TDP-43.
Colonic Neoplasms
Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol.
Colonic Neoplasms
Inhibition of topoisomerase II by phase II metabolites of resveratrol in human colon cancer cells.
Colonic Neoplasms
Integration of transcriptomics and metabolomics reveals anlotinib-induced cytotoxicity in colon cancer cells.
Colonic Neoplasms
ki-67 and Topoisomerase IIa proliferation markers in colon adenocarcinoma.
Colonic Neoplasms
Knockdown of Parkinson's disease-related gene ATP13A2 reduces tumorigenesis via blocking autophagic flux in colon cancer.
Colonic Neoplasms
Markers of drug resistance in relapsing colon cancer.
Colonic Neoplasms
Multidrug resistance proteins and topoisomerase IIalpha expression in colon cancer: association with metastatic potential.
Colonic Neoplasms
P-Gp and TOPO II Expression and Their Clinical Significance in Colon Cancer.
Colonic Neoplasms
Potential role for the Metnase transposase fusion gene in colon cancer through the regulation of key genes.
Colonic Neoplasms
Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.
Colonic Neoplasms
Proliferation and invasion of colon cancer cells are suppressed by knockdown of TOP2A.
Colonic Neoplasms
Resveratrol induces DNA damage in colon cancer cells by poisoning topoisomerase II and activates the ATM kinase to trigger p53-dependent apoptosis.
Colonic Neoplasms
Selective killing of G2 decatenation checkpoint defective colon cancer cells by catalytic topoisomerase II inhibitor.
Colonic Neoplasms
Stromal extracellular matrix reduces chemotherapy-induced apoptosis in colon cancer cell lines.
Colonic Neoplasms
Synthesis and identification of novel indolo[2,3-a]pyrimido[5,4-c]carbazoles as a new class of anti-cancer agents.
Colonic Neoplasms
Topotecan increases topoisomerase IIalpha levels and sensitivity to treatment with etoposide in schedule-dependent process.
Colonic Neoplasms
[Prognostic values of the clinical, morphological and molecular biological characteristics of colon adenocarcinoma].
Colorectal Neoplasms
A covalent p97/VCP ATPase inhibitor can overcome resistance to CB-5083 and NMS-873 in colorectal cancer cells.
Colorectal Neoplasms
A phase II study of Epirubicin in oxaliplatin-resistant patients with metastatic colorectal cancer and TOP2A gene amplification.
Colorectal Neoplasms
Association between p53 expression and Bcl-2, P-glycoprotein, topoisomerase II alpha, thymidylate synthase and thymidine phosphorylase as potential therapeutic targets in colorectal cancer patients.
Colorectal Neoplasms
ATAD2 overexpression is associated with progression and prognosis in colorectal cancer.
Colorectal Neoplasms
ATAD2 silencing decreases VEGFA secretion through targeting has-miR-520a to inhibit angiogenesis in colorectal cancer.
Colorectal Neoplasms
Cancer cell adaptation to chemotherapy.
Colorectal Neoplasms
Clonality characterization of natural epitope-specific antibodies against the tumor-related antigen topoisomerase IIa by peptide chip and proteome analysis: a pilot study with colorectal carcinoma patient samples.
Colorectal Neoplasms
Context-specific role of SOX9 in NF-Y mediated gene regulation in colorectal cancer cells.
Colorectal Neoplasms
Daurinol, a catalytic inhibitor of topoisomerase II?, suppresses SNU-840 ovarian cancer cell proliferation through cell cycle arrest in S phase.
Colorectal Neoplasms
Down-regulation of DNA topoisomerase IIalpha in human colorectal carcinoma cells resistant to a protoberberine alkaloid, berberrubine.
Colorectal Neoplasms
Enhanced coexpression of YB-1 and DNA topoisomerase II alpha genes in human colorectal carcinomas.
Colorectal Neoplasms
Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complex.
Colorectal Neoplasms
HER2, TOP2A, CCND1, EGFR and C-MYC oncogene amplification in colorectal cancer.
Colorectal Neoplasms
Identification of Common Genes Refers to Colorectal Carcinogenesis with Paired Cancer and Noncancer Samples.
Colorectal Neoplasms
Increased topoisomerase IIalpha expression in colorectal cancer is associated with advanced disease and chemotherapeutic resistance via inhibition of apoptosis.
Colorectal Neoplasms
Ouabain-induced alterations of the apical junctional complex involve ?1 and ?1 Na,K-ATPase downregulation and ERK1/2 activation independent of caveolae in colorectal cancer cells.
Colorectal Neoplasms
Prognostic relevance of topoisomerase II ? and minichromosome maintenance protein 6 expression in colorectal cancer.
Colorectal Neoplasms
Silencing of ATPase family AAA domain-containing protein 2 inhibits migration and invasion of colorectal cancer cells.
Colorectal Neoplasms
Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer.
Colorectal Neoplasms
The role of the DNA mismatch repair system in the cytotoxicity of the topoisomerase inhibitors camptothecin and etoposide to human colorectal cancer cells.
Colorectal Neoplasms
Topoisomerase II gene mutations in tumors and tumor cell lines with microsatellite instability.
Colorectal Neoplasms
Topoisomerase-1 and -2A gene copy numbers are elevated in mismatch repair-proficient colorectal cancers.
Colorectal Neoplasms
TRAP1, a novel mitochondrial chaperone responsible for multi-drug resistance and protection from apoptotis in human colorectal carcinoma cells.
Colorectal Neoplasms
Underpinning the repurposing of anthracyclines towards colorectal cancer: assessment of topoisomerase II alpha gene copy number alterations in colorectal cancer.
Colorectal Neoplasms
Up-regulation of Na(+),K(+)-ATPase alpha 3-isoform and down-regulation of the alpha1-isoform in human colorectal cancer.
Colorectal Neoplasms
UPF1 promotes chemoresistance to oxaliplatin through regulation of TOP2A activity and maintenance of stemness in colorectal cancer.
Colorectal Neoplasms
ZNF148 modulates TOP2A expression and cell proliferation via ceRNA regulatory mechanism in colorectal cancer.
Colorectal Neoplasms
[Efficacy of hepatic arterial infusion of adriamycin and mitomycin C mixed with degradable starch microspheres for liver metastasis of colorectal cancer--correlation with the mRNA expression of DNA topoisomerase-IIalpha and glutathione-S transferase-pi in primary lesions]
Colorectal Neoplasms
[Expression of glutathione S-transferase-pi and DNA topoisomerase II alpha and their implications in colorectal carcinoma]
Colorectal Neoplasms
[Expression of P-gp, GST-pi and Topo IIalpha in gastric and colorectal cancers and their clinical significance.]
Colorectal Neoplasms
[Expression of topoisomerase II alpha in human colorectal carcinoma and its significance.]
Colorectal Neoplasms
[Prophylaxis of acute postoperative gastroduodenal ulcers at the patients with colorectal cancer]
Colorectal Neoplasms
[The activity of adenosinetriphosphatase of erythrocytes in peripheral blood of patients with colorectal cancer]
Coma
Mutagenesis separates ATPase and thioesterase activities of the peroxisomal ABC transporter, Comatose.
Coma
Palytoxin Poisoning After Dermal Contact with Zoanthid Coral.
Coma
The Arabidopsis peroxisomal ABC transporter, comatose, complements the Saccharomyces cerevisiae pxa1 pxa2Delta mutant for metabolism of long-chain fatty acids and exhibits fatty acyl-CoA-stimulated ATPase activity.
Communicable Diseases
Dexrazoxane (ICRF-187).
Community-Acquired Infections
In vitro characterization of the antibacterial spectrum of novel bacterial type II topoisomerase inhibitors of the aminobenzimidazole class.
Community-Acquired Infections
Quercetin diacylglycoside analogues showing dual inhibition of DNA gyrase and topoisomerase IV as novel antibacterial agents.
Confusion
Congenital myopathy with mosaic fibers and interlacing sarcomeres: a new structural myopathy.
Congenital Disorders of Glycosylation
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Congenital Hypothyroidism
Factors determining the differential tissue response of Na/K-ATPase to thyroid hormone in the neonatal rat.
Congenital Hypothyroidism
[Influence of congenital hypothyroidism on the developing rat brain and improvement after thyroid replacement therapy]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Connective Tissue Diseases
Autoantibodies to DNA topoisomerase II in cryptogenic fibrosing alveolitis and connective tissue disease.
Contracture
Cardiac glycosides and intracellular Na+, K+, Ca2+.
Contracture
EFFECTS OF COCAINE AND ADRENALINE ON CONTRACTURES AND DOWNHILL ION MOVEMENTS INDUCED BY INHIBITORS OF MEMBRANE ATPASE IN RAT UTERI.
Contracture
Fiber-type caffeine sensitivities in skinned muscle fibers from humans susceptible to malignant hyperthermia.
Contracture
Fiber-type specific caffeine sensitivities in normal human skinned muscle fibers.
Contracture
Hereditary inclusion-body myopathies.
Contracture
Myosin heavy chain mutations that cause Freeman-Sheldon syndrome lead to muscle structural and functional defects in Drosophila.
Contracture
THE CORRELATION OF INHIBITION OF UPHILL ION MOVEMENTS AND INITIATION OF CONTRACTURE IN INTACT RAT MYOMETRIUM WITH INHIBITION OF MG AND NA+K-ACTIVATED ATPASE IN MYOMETRIAL HOMOGENATES.
Contracture
The pathogenesis of Dupuytren's contracture: contractile mechanisms of the myofibroblasts.
Corneal Edema
Effect of inflammation on the corneal endothelial pump and barrier.
Corneal Edema
Extensive bilateral corneal edema 6 weeks after cataract surgery: Keratopathy due to Asclepias physocarpa: a case report.
Coronary Artery Disease
Inhibition of membrane Na(+)-K+ Atpase of the brain, liver and RBC in rats administered di(2-ethyl hexyl) phthalate (DEHP) a plasticizer used in polyvinyl chloride (PVC) blood storage bags.
Coronary Disease
Structural analysis of the minisatellite present at the 3' end of the human apolipoprotein B gene: new definition of the alleles and evolutionary implications.
Coronary Disease
[Changes of erythrocyte membrane ATPase activities and plasma lipids in patients with coronary heart disease]
Coronary Disease
[Investigation on traditional Chinese medicine and Western medicine susceptible factors on senile cataract]
Coronary Disease
[The effect of the alimentary factor on erythrocyte ATPase activity in ischemic heart disease patients]
Coronary Disease
[The relation between oxidative processes and the glycogen content in the heart and liver of rabbits with chronic ischemic heart disease]
Coronary Occlusion
High-energy phosphate and mitochondrial Mg-2 plus-stimulated ATPase activities in ischemic and nonischemic areas of the myocardium with acute experimental coronary occlusion.
Coronary Occlusion
Studies of the cardiac sarcoplasmic reticulum in myocardial infarction.
Coronary Occlusion
[Effect of prolonged beta-adrenergic blockade on myocardial energy metabolism in coronary occlusion]
Coronary Stenosis
Increase in plasma digitalis-like activity during percutaneous transluminal coronary angioplasty in patients with coronary stenosis.
Coronavirus Infections
Coronavirus interactions with the cellular autophagy machinery.
Cough
Selective expression of a sodium pump isozyme by cough receptors and evidence for its essential role in regulating cough.
Cough
Transcript map of the candidate region for HSNI with cough and gastroesophageal reflux on chromosome 3p and exclusion of candidate genes.
COVID-19
Coronavirus interactions with the cellular autophagy machinery.
Coxsackievirus Infections
[Muscle tissue ATPase in experimental Coxsackie virus infections.]
Craniocerebral Trauma
Effect of gamma-hydroxybutyric acid on tissue Na+,K- ATPase levels after experimental head trauma.
Craniocerebral Trauma
The effect of the treatment of high-dose methylprednisolone on Na(+)-K(+)/Mg(+2) ATPase activity and lipid peroxidation and ultrastructural findings following cerebral contusion in rat.
Craniocerebral Trauma
The prognostic value of the brain sodium-potassium ATPase enzyme concentration in head injury.
Craniopharyngioma
Expression of human MCM6 and DNA Topo II alpha in craniopharyngiomas and its correlation with recurrence of the tumor.
Cryptosporidiosis
[Cardiomyocyte myosin heavy chain composition change after cryptosporidial gastroenteritis].
Cushing Syndrome
Na-K-ATPase in erythrocyte ghosts is not a marker for primary hypertension.
Cutis Laxa
Impaired glycosylation and cutis laxa caused by mutations in the vesicular H+-ATPase subunit ATP6V0A2.
Cutis Laxa
Loss-of-Function Mutations in ATP6V0A2 Impair Vesicular Trafficking, Tropoelastin Secretion, and Cell Survival.
Cutis Laxa
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Cystadenocarcinoma, Mucinous
Immunohistochemical and two-parameter flow cytometric studies of DNA topoisomerase II alpha in human epithelial ovarian carcinoma and germ cell tumor.
Cystadenocarcinoma, Serous
Immunohistochemical and two-parameter flow cytometric studies of DNA topoisomerase II alpha in human epithelial ovarian carcinoma and germ cell tumor.
Cystadenoma
DNA topoisomerase IIalpha and -beta expression in human ovarian cancer.
Cystadenoma, Serous
Expression of cellular apoptosis susceptibility protein in serous ovarian carcinoma: a clinicopathologic and immunohistochemical study.
Cystic Fibrosis
A heteromeric complex of the two nucleotide binding domains of cystic fibrosis transmembrane conductance regulator (CFTR) mediates ATPase activity.
Cystic Fibrosis
A monomer is the minimum functional unit required for channel and ATPase activity of the cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
A recombinant polypeptide model of the second nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator functions as an active ATPase, GTPase and adenylate kinase.
Cystic Fibrosis
A small molecule that binds to an ATPase domain of Hsc70 promotes membrane trafficking of mutant cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
A study of erythrocyte fatty acids, adenosinetriphosphatase and acetylcholinesterase in cystic fibrosis.
Cystic Fibrosis
ATPase activity of the cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
Biochemical evidence for ATPase activity in CFTR-enriched apical membrane vesicles from tracheal epithelium.
Cystic Fibrosis
Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis.
Cystic Fibrosis
Calcium and sodium transport processes in patients with cystic fibrosis 2. Mg2+- dependent, Ca2+ ATPase activity in fibroblast membrane preparations from cystic fibrosis patients and controls.
Cystic Fibrosis
Changes in erythrocyte membrane ATPase in patients with cystic fibrosis of the pancreas.
Cystic Fibrosis
Chloride channels: a molecular perspective.
Cystic Fibrosis
Cl- channels regulate lipid droplet formation via Rab8a expression during adipocyte differentiation.
Cystic Fibrosis
Conditioned media from cultured cystic fibrosis fibroblasts inhibits Na/K ATPase activity.
Cystic Fibrosis
Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain 1 (NBD-1) and CFTR truncated within NBD-1 target to the epithelial plasma membrane and increase anion permeability.
Cystic Fibrosis
Cystic fibrosis: effect of media from cultured cystic fibrosis fibroblasts on ATPase activity.
Cystic Fibrosis
Cystic fibrosis: the effect of medium from cultured cystic fibrosis fibroblasts on ATPase activity.
Cystic Fibrosis
Depressed (Ca++)-transport ATPase in cystic fibrosis erythrocytes.
Cystic Fibrosis
Determination and characterization of ciliary ATPase in the presence of serum from cystic fibrosis patients.
Cystic Fibrosis
Estrogen regulation of ion transporter messenger RNA levels in mouse efferent ductules are mediated differentially through estrogen receptor (ER) alpha and ER beta.
Cystic Fibrosis
Expressional Changes of Water Transport-related Molecules in the Efferent Ductules and Initial Segment of Mouse Treated with Bisphenol A-Containing Drinking Water for Two Generations.
Cystic Fibrosis
Functional roles of the nucleotide-binding folds in the activation of the cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
Genome-wide analysis of MicroRNA-messenger RNA interactome in ex-vivo gill filaments, Anguilla japonica.
Cystic Fibrosis
How Phosphorylation and ATPase Activity Regulate Anion Flux though the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).
Cystic Fibrosis
How phosphorylation and ATPase activity regulate anion flux through the cystic fibrosis transmembrane conductance regulator (CFTR).
Cystic Fibrosis
Identification of differentially expressed genes in normal and tumor human gastric tissue.
Cystic Fibrosis
Inhibition of ATPase, GTPase and adenylate kinase activities of the second nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator by genistein.
Cystic Fibrosis
Inhibition of ouabain-sensitive ATPase by the saliva of patients with cystic fibrosis of the pancreas.
Cystic Fibrosis
Ivacaftor, a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator, Enhances Ciprofloxacin Activity Against Pseudomonas aeruginosa.
Cystic Fibrosis
l-Methionine anti-biofilm activity against Pseudomonas aeruginosa is enhanced by the cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor.
Cystic Fibrosis
On the mechanism of MgATP-dependent gating of CFTR Cl- channels.
Cystic Fibrosis
Orphan enzyme or patriarch of a new tribe: the arsenic resistance ATPase of bacterial plasmids.
Cystic Fibrosis
P2Z-Independent and P2Z receptor-mediated macrophage killing by Pseudomonas aeruginosa isolated from cystic fibrosis patients.
Cystic Fibrosis
Perturbation of the pore of the cystic fibrosis transmembrane conductance regulator (CFTR) inhibits its atpase activity.
Cystic Fibrosis
Production and effects of alpha-melanocyte-stimulating hormone during acute lung injury.
Cystic Fibrosis
Role of natriuretic peptides in ion transport mechanisms.
Cystic Fibrosis
Saccharomyces cerivisiae as a model system for kidney disease: what can yeast tell us about renal function?
Cystic Fibrosis
Skin ionocyte remodeling in the amphibious mangrove rivulus fish (Kryptolebias marmoratus).
Cystic Fibrosis
Targeted Gene Next-Generation Sequencing in Chinese Children with Chronic Pancreatitis and Acute Recurrent Pancreatitis.
Cystic Fibrosis
The first nucleotide binding fold of the cystic fibrosis transmembrane conductance regulator can function as an active ATPase.
Cystic Fibrosis
Walker mutations reveal loose relationship between catalytic and channel-gating activities of purified CFTR (cystic fibrosis transmembrane conductance regulator).
Cystinosis
Proton-translocating ATPase and lysosomal cystine transport.
Cystinosis
Role of adenosine triphosphate (ATP) and NaK ATPase in the inhibition of proximal tubule transport with intracellular cystine loading.
Cysts
Congenital murine polycystic kidney disease. II. Pathogenesis of tubular cyst formation.
Cysts
Correction: DNA Topoisomerase II Is Involved in Regulation of Cyst Wall Protein Genes and Differentiation in Giardia lamblia.
Cysts
DNA topoisomerase II is involved in regulation of cyst wall protein genes and differentiation in Giardia lamblia.
Cysts
Ecto-nucleotidases activities in the contents of ovarian endometriomas: potential biomarkers of endometriosis.
Cysts
Effect of antihydatid drugs on carbohydrate metabolism of metacestode of echinococcus granulosus.
Cysts
Effects of lead on K(+)-para-nitrophenyl phosphatase activity and protection by thiol reagents.
Cysts
Effects of mebendazole, albendazole, and praziquantel on alkaline phosphatase, acid phosphatase, and adenosine triphosphatase of Echinococcus granulosus cysts harbored in mice.
Cysts
EPEC effector EspF promotes Crumbs3 endocytosis and disrupts epithelial cell polarity.
Cysts
Fundic gland cysts in Atp4a-/- mice mimic fundic gland polyps in humans.
Cysts
In vitro modulation of tubular cyst regression in murine polycystic kidney disease.
Cysts
Na-K ATPase activity in murine glucocorticoid induced polycystic kidney disease in vivo.
Cysts
Sodium-potassium ATPase activity mediates cyst formation in metanephric organ culture.
Cytomegalovirus Infections
Effect of Annexin V on Development of Apoptosis in Placental Syncytiotrophoblast Nuclei during Exacerbation of Cytomegalovirus Infection in the Third Trimester.
Cytomegalovirus Infections
Irreversible inhibition of human cytomegalovirus replication by topoisomerase II inhibitor, etoposide: a new strategy for the treatment of human cytomegalovirus infection.
Darier Disease
A Japanese case of segmental Darier's disease caused by mosaicism for the ATP2A2 mutation.
Darier Disease
Darier disease in Slovenia: spectrum of ATP2A2 mutations and relation to patients' phenotypes.
Darier Disease
Darier's disease: a calcium-signaling perspective.
Darier Disease
Darier's disease: from dyskeratosis to endoplasmic reticulum calcium ATPase deficiency.
Darier Disease
Effects of drugs and anticytokine antibodies on expression of ATP2A2 and ATP2C1 in cultured normal human keratinocytes.
Darier Disease
Exclusion of the Darier's disease gene, ATP2A2, as a common susceptibility gene for bipolar disorder.
Darier Disease
Lithium suppresses epidermal SERCA2 and PMR1 levels in the rat.
Darier Disease
Mosaicism for ATP2A2 mutations causes segmental Darier's disease.
Darier Disease
Mutational analysis of the ATP2A2 gene in two Darier disease families with intrafamilial variability.
Darier Disease
P160L mutation in the Ca(2+) ATPase 2A domain in a patient with severe Darier disease.
Darier Disease
SERCA2-Controlled Ca(2+)-Dependent Keratinocyte Adhesion and Differentiation Is Mediated via the Sphingolipid Pathway: A Therapeutic Target for Darier's Disease.
Darier Disease
The association between Darier disease, bipolar disorder, and schizophrenia revisited: a population-based family study.
Deafness
Familial renal tubular acidosis.
Deafness
Genetic causes and mechanisms of distal renal tubular acidosis.
Deafness
Hair cells, plasma membrane Ca(2+) ATPase and deafness.
Deafness
Hereditary distal renal tubular acidosis: new understandings.
Deafness
The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 human deafness.
Death, Sudden, Cardiac
Endothelin receptor antagonist CPU0213 and vitamin E reverse downregulation of FKBP12.6 and SERCA2a: a role of hyperphosphorylation of PKCepsilon.
Death, Sudden, Cardiac
[Changes in the ATPase activity of cell structures of the myocardium and brain in sudden cardiac death]
Decompression Sickness
Asymmetric removal of supercoils suggests how topoisomerase II simplifies DNA topology.
Decompression Sickness
Nucleotide-induced global conformational changes of flagellar dynein arms revealed by in situ analysis.
Decompression Sickness
Structure and energetics of an allele-specific genetic interaction between dnaJ and dnaK: correlation of nuclear magnetic resonance chemical shift perturbations in the J-domain of Hsp40/DnaJ with binding affinity for the ATPase domain of Hsp70/DnaK.
Decompression Sickness
The Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage.
Decompression Sickness
Topoisomerase IV bends and overtwists DNA upon binding.
Decompression Sickness
Topoisomerase VI senses and exploits both DNA crossings and bends to facilitate strand passage.
Decompression Sickness
[Mechanism of glycerol and methanol action on soluble ATPase of mitochondria]
Deficiency Diseases
Dietary selenium increases the antioxidant levels and ATPase activity in the arteries and veins of poultry.
Dehydration
A novel method for determining rate constants for dehydration of aldehyde hydrates.
Dehydration
A Reciprocal (15)N-Labeling Proteomic Analysis of Expanding Arabidopsis Leaves Subjected to Osmotic Stress Indicates Importance of Mitochondria in Preserving Plastid Functions.
Dehydration
Effect of dehydration, food deprivation, saline and adrenalectomy on microsomal (Na + +K + )-dependent ATPase in the salivary glands and intestinal mucosa.
Dehydration
Effect of dehydration, starvation and sodium deprivation on microsomal ATPase in the kidney.
Dehydration
Mapping of Plasma Membrane Proteins Interacting With Arabidopsis thaliana Flotillin 2.
Dehydration
Possible CO2 concentrating mechanism in chloroplasts of C3 plants. Role of carbonic anhydrase.
Dehydration
[Membrane-bound carbonic anhydrase (CA IV) in human corneal epithelium and endothelium]
Dementia
Pathological lesions of Alzheimer's disease and dementia with Lewy bodies brains exhibit immunoreactivity to an ATPase that is a regulatory subunit of the 26S proteasome.
Dengue
Aedes aegypti SNAP and a calcium transporter ATPase influence dengue virus dissemination.
Dengue
Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase.
Dengue
Identification and biochemical characterization of halisulfate 3 and suvanine as novel inhibitors of hepatitis C virus NS3 helicase from a marine sponge.
Dengue
Production and characterization of a monoclonal antibody specific for NS3 protease and the ATPase region of Dengue-2 virus.
Dengue
Structure-based mutational analysis of the NS3 helicase from dengue virus.
Dengue
Synthetic 1,4-pyran naphthoquinones are potent inhibitors of dengue virus replication.
Dermatitis
Density of Langerhans' cells in ATPase stained epidermal sheet preparations from stasis dermatitis skin of the lower leg.
Dermatitis, Atopic
Inhibition of histamine release from human granulocytes by ions of the rare earth elements lanthanum and cerium.
Dermatitis, Contact
Relationship between epidermal Langerhans cell density ATPase activity and the induction of contact hypersensitivity.
Dermatitis, Contact
Squalene peroxides may contribute to ultraviolet light-induced immunological effects.
Dermatitis, Contact
Studies on the effects of a high dose UVA-1 radiation therapy on surface markers and function of epidermal Langerhans cells.
Dermatitis, Contact
[Formation of Langerhans granules seems linked to membrane ATPase activity of epidermal Langerhans cells]
Diabetes Complications
Renal ouabain inhibitable Na-K ATPase activity and myoinositol supplementation in experimental diabetes mellitus.
Diabetes Complications
[Potential therapeutic approaches for prevention and treatment of diabetic nephropathy and neuropathy: evidences of cilostazol]
Diabetes Insipidus
Influence of chronic ADH treatment on adenylate cyclase and ATPase activity in distal nephron segments of diabetes insipidus Brattleboro rats.
Diabetes Mellitus
Abnormal cation exchange in insulin-resistant patients with essential hypertension.
Diabetes Mellitus
Adaptation of small intestinal membrane transport processes during diabetes mellitus in rats.
Diabetes Mellitus
Association of diabetic neuropathy with Na/K ATPase gene polymorphism.
Diabetes Mellitus
Autoantibodies against IA-2, GAD, and topoisomerase II in type 1 diabetic patients.
Diabetes Mellitus
Biochemical changes in erythrocyte membrane in uncontrolled type 2 diabetes mellitus.
Diabetes Mellitus
Cardiac contracile protein ATPase activity in a diet induced model of noninsulin dependent diabetes mellitus.
Diabetes Mellitus
Cardiomyopathies and mitochondrial DNA mutations.
Diabetes Mellitus
Differences in the Force-Interval. Relationship of Isolated Human Myocardium with Chronic Coronary Artery Diseasein Patients with and without Type 2 Diabetes Mellitus and the Role of Ca²?-ATPase of Sarcoplasmic Reticulum.
Diabetes Mellitus
Enhanced Na-K ATPase activity in the aorta may explain the unaltered contractile responses to KCl in diabetes mellitus.
Diabetes Mellitus
Enhanced renal tubular ouabain-sensitive ATPase in streptozotocin diabetes mellitus.
Diabetes Mellitus
Impaired rat sciatic nerve sodium-potassium adenosine triphosphatase in acute streptozocin diabetes and its correction by dietary myo-inositol supplementation.
Diabetes Mellitus
Modulation of skeletal muscle performance and SERCA by exercise and adiponectin gene therapy in insulin-resistant rat.
Diabetes Mellitus
NO levels in diabetes mellitus: Effects of l-NAME and insulin on LCAT, Na(+)/K(+) ATPase activity and lipid profile.
Diabetes Mellitus
Reduced lecithin: cholesterol acyltransferase (LCAT) and Na+, K+, ATPase activity in diabetic patients.
Diabetes Mellitus
Relationship between autoantibodies against glutamic acid decarboxylase, thyroglobulin/thyroid microsome and DNA topoisomerase II in the clinical manifestation of patients with type 1 diabetes mellitus in Taiwan.
Diabetes Mellitus
Renal ouabain inhibitable Na-K ATPase activity and myoinositol supplementation in experimental diabetes mellitus.
Diabetes Mellitus
[Activity of membrane-bound protein kinase C and ATPase in erythrocytes in diabetic angiopathy]
Diabetes Mellitus
[Clinical significance of erythrocyte (Na(+)-K+) ATPase activity in the diagnosis of diabetes mellitus and their complications]
Diabetes Mellitus
[Effect of alloxan diabetes on (Na+ + K+)-activated ATPase in brush border membrane of the mucosal cell of rat small intestine]
Diabetes Mellitus, Experimental
Enhanced renal tubular ouabain-sensitive ATPase in streptozotocin diabetes mellitus.
Diabetes Mellitus, Experimental
Renal ouabain inhibitable Na-K ATPase activity and myoinositol supplementation in experimental diabetes mellitus.
Diabetes Mellitus, Experimental
[Detection of a Na+-activated, furosemide-inhibited ATPase activity in rat intestinal mucosa]
Diabetes Mellitus, Type 1
Association of diabetic neuropathy with Na/K ATPase gene polymorphism.
Diabetes Mellitus, Type 1
Autoantibodies against IA-2, GAD, and topoisomerase II in type 1 diabetic patients.
Diabetes Mellitus, Type 1
Characterization of human DNA topoisomerase II as an autoantigen recognized by patients with IDDM.
Diabetes Mellitus, Type 1
Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells.
Diabetes Mellitus, Type 1
Platelet sodium and potassium ATPase [corrected] activity and noradrenaline efflux rate in relation to autonomic and peripheral nerve function in insulin-dependent diabetic patients.
Diabetes Mellitus, Type 1
Reduced lecithin: cholesterol acyltransferase (LCAT) and Na+, K+, ATPase activity in diabetic patients.
Diabetes Mellitus, Type 1
Relationship between autoantibodies against glutamic acid decarboxylase, thyroglobulin/thyroid microsome and DNA topoisomerase II in the clinical manifestation of patients with type 1 diabetes mellitus in Taiwan.
Diabetes Mellitus, Type 1
Relationship between neuropathy, hypertension and red blood cell Na/K ATPase in patients with insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 2
Biochemical changes in erythrocyte membrane in uncontrolled type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Cardiac contracile protein ATPase activity in a diet induced model of noninsulin dependent diabetes mellitus.
Diabetes Mellitus, Type 2
Erythrocyte membrane digoxin-sensitive (Na(+)-K+)-ATPase of non-insulin dependent diabetic humans.
Diabetes Mellitus, Type 2
Evidence for mechanistic alterations of Ca2+ homeostasis in Type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Hormone-specific defect in insulin regulation of (Ca2+ + Mg2+)-adenosine triphosphatase activity in kidney membranes from streptozocin non-insulin-dependent diabetic rats.
Diabetes Mellitus, Type 2
Modulation of skeletal muscle performance and SERCA by exercise and adiponectin gene therapy in insulin-resistant rat.
Diabetes Mellitus, Type 2
Reduced lecithin: cholesterol acyltransferase (LCAT) and Na+, K+, ATPase activity in diabetic patients.
Diabetes Mellitus, Type 2
Reinterpreting the action of ATP analogs on K(ATP) channels.
Diabetes, Gestational
Comparison of Serum Levels of Fructosamine and Erythrocyte Sodium Potassium ATPase (Na+/K+ ATPase) in Gestational Diabetes Mellitus (GDM) and non-Gestational Diabetes Mellitus (non GDM) Patients.
Diabetic Angiopathies
[Activity of membrane-bound protein kinase C and ATPase in erythrocytes in diabetic angiopathy]
Diabetic Cardiomyopathies
Cardiac sarcolemmal Na(+)-Ca2+ exchange and Na(+)-K+ ATPase activities and gene expression in alloxan-induced diabetes in rats.
Diabetic Cardiomyopathies
Myosin light-chain phosphorylation in diabetic cardiomyopathy in rats.
Diabetic Cardiomyopathies
Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy.
Diabetic Nephropathies
SMAD3 promotes autophagy dysregulation by triggering lysosome depletion in tubular epithelial cells in diabetic nephropathy.
Diabetic Neuropathies
A defect in sodium-dependent amino acid uptake in diabetic rabbit peripheral nerve. Correction by an aldose reductase inhibitor or myo-inositol administration.
Diabetic Neuropathies
Association of diabetic neuropathy with Na/K ATPase gene polymorphism.
Diabetic Neuropathies
C-peptide, Na+,K(+)-ATPase, and diabetes.
Diabetic Neuropathies
Decreased Na/K ATPase ouabain binding sites in red blood cells of patients with insulin-dependent diabetes and healthy north African control subjects: relationship with diabetic neuropathy.
Diabetic Neuropathies
Diabetic neuropathy in db/db mice develops independently of changes in ATPase and aldose reductase. A biochemical and immunohistochemical study.
Diabetic Neuropathies
Metabolic effect of PGE1 analogue 01206.alpha CD on nerve Na(+)-K(+)-ATPase activity of rats with streptozocin-induced diabetes is mediated via cAMP: possible role of cAMP in diabetic neuropathy.
Diabetic Neuropathies
N-acetylcysteine Inhibits Hyperglycemia-induced Oxidative Stress and Apoptosis Markers in Diabetic Neuropathy.
Diabetic Neuropathies
Neural dysfunction and metabolic imbalances in diabetic rats. Prevention by acetyl-L-carnitine.
Diabetic Neuropathies
Platelet sodium and potassium ATPase [corrected] activity and noradrenaline efflux rate in relation to autonomic and peripheral nerve function in insulin-dependent diabetic patients.
Diabetic Neuropathies
Relationship between neuropathy, hypertension and red blood cell Na/K ATPase in patients with insulin-dependent diabetes mellitus.
Diabetic Neuropathies
[Genetic factors, Na K ATPase activity and neuropathy in diabetics]
Diabetic Retinopathy
Abnormalities of retinal metabolism in diabetes or galactosemia: ATPases and glutathione.
Disorders of Sex Development
Sex differences in autophagy-mediated diseases: toward precision medicine.
dna topoisomerase (atp-hydrolysing) deficiency
Bacillus megaterium mutant deficient in membrane-bound adenosine triphosphatase activity.
dna topoisomerase (atp-hydrolysing) deficiency
Biochemical consequences in yeast of the human mitochondrial DNA 8993T>C mutation in the ATPase6 gene found in NARP/MILS patients.
dna topoisomerase (atp-hydrolysing) deficiency
Cytological and genetic consequences for the progeny of a mitotic catastrophe provoked by Topoisomerase II deficiency.
dna topoisomerase (atp-hydrolysing) deficiency
Darier's disease: from dyskeratosis to endoplasmic reticulum calcium ATPase deficiency.
dna topoisomerase (atp-hydrolysing) deficiency
Distinct roles of Topoisomerase II isoforms: DNA damage accelerating alpha, double strand break repair promoting beta.
dna topoisomerase (atp-hydrolysing) deficiency
Double-strand break repair and genetic recombination in topoisomerase and primase mutants of bacteriophage T4.
dna topoisomerase (atp-hydrolysing) deficiency
Erythrocyte sodium-potassium-stimulated adenosine triphosphatase activity is not related to obesity.
dna topoisomerase (atp-hydrolysing) deficiency
Escherichia coli DNA topoisomerase I mutants have compensatory mutations in DNA gyrase genes.
dna topoisomerase (atp-hydrolysing) deficiency
Genome-Scale Genetic Interactions and Cell Imaging Confirm Cytokinesis as Deleterious to Transient Topoisomerase II Deficiency in Saccharomyces cerevisiae.
dna topoisomerase (atp-hydrolysing) deficiency
Interference with topoisomerase IIalpha potentiates melphalan cytotoxicity.
dna topoisomerase (atp-hydrolysing) deficiency
Loss of Na(+)/K(+)-ATPase in Drosophila photoreceptors leads to blindness and age-dependent neurodegeneration.
dna topoisomerase (atp-hydrolysing) deficiency
P4 ATPases - Lipid flippases and their role in disease.
dna topoisomerase (atp-hydrolysing) deficiency
Phenotypic suppression of DNA gyrase deficiencies by a deletion lowering the gene dosage of a major tRNA in Salmonella typhimurium.
dna topoisomerase (atp-hydrolysing) deficiency
PRICKLE3 linked to ATPase biogenesis manifested Leber's hereditary optic neuropathy.
dna topoisomerase (atp-hydrolysing) deficiency
Quantitative aspects of chemical carcinogenesis and tumor promotion in liver.
dna topoisomerase (atp-hydrolysing) deficiency
Reduced respiratory control with ADP and changed pattern of respiratory chain enzymes as a result of selective deficiency of the mitochondrial ATP synthase.
dna topoisomerase (atp-hydrolysing) deficiency
Sodium-potssum tmulated ATPase activity of mammalian hemolysates: clinical observations and ominance of ATPase deficiency in the potassium polymorphism of sheep.
dna topoisomerase (atp-hydrolysing) deficiency
Study of the separate and combined effects of the non-planar 2,5,2',5'- and the planar 3,4,3',4'-tetrachlorobiphenyl in liver and lymphocytes in vivo.
dna topoisomerase (atp-hydrolysing) deficiency
Superoxide-induced massive apoptosis in cultured skin fibroblasts harboring the neurogenic ataxia retinitis pigmentosa (NARP) mutation in the ATPase-6 gene of the mitochondrial DNA.
dna topoisomerase (atp-hydrolysing) deficiency
Synthesis and preliminary biological evaluations of ionic and nonionic amphiphilic alpha-phenyl-N-tert-butylnitrone derivatives.
dna topoisomerase (atp-hydrolysing) deficiency
Synthesis of cytochrome c oxidase subunit 1 is translationally downregulated in the absence of functional F(1)F(0)-ATP synthase.
dna topoisomerase (atp-hydrolysing) deficiency
The leader peptide of yeast Atp6p is required for efficient interaction with the Atp9p ring of the mitochondrial ATPase.
dna topoisomerase (atp-hydrolysing) deficiency
The mtDNA NARP mutation activates the actin-Nrf2 signaling of antioxidant defenses.
dna topoisomerase (atp-hydrolysing) deficiency
The neurogenic weakness, ataxia and retinitis pigmentosa (NARP) syndrome mtDNA mutation (T8993G) triggers muscle ATPase deficiency and hypocitrullinaemia.
dna topoisomerase (atp-hydrolysing) deficiency
Topoisomerase I Essentiality, DnaA-Independent Chromosomal Replication, and Transcription-Replication Conflict in Escherichia coli.
dna topoisomerase (atp-hydrolysing) deficiency
Topoisomerase II deficiency leads to a postreplicative structural shift in all Saccharomyces cerevisiae chromosomes.
dna topoisomerase (atp-hydrolysing) deficiency
Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells.
dna topoisomerase (atp-hydrolysing) deficiency
Torsin ATPase deficiency leads to defects in nuclear pore biogenesis and sequestration of MLF2.
dna topoisomerase deficiency
gyrB-225, a mutation of DNA gyrase that compensates for topoisomerase I deficiency: investigation of its low activity and quinolone hypersensitivity.
Down Syndrome
Acute myeloid leukaemia in children.
Down Syndrome
ATPase activity of erythrocyte membrane in patients with trisomy 21 (Down's syndrome).
Down Syndrome
Decreased ATPase and increased sodiun content of platelets in Down's syndrome. Relation to decreased serotonin content.
Down Syndrome
Endogenous sodium-potassium ATPase inhibition related biochemical cascade in trisomy 21 and Huntington's disease: neural regulation of genomic function.
Drug Hypersensitivity
Increased drug affinity as the mechanistic basis for drug hypersensitivity of a mutant type II topoisomerase.
Drug-Related Side Effects and Adverse Reactions
A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer.
Drug-Related Side Effects and Adverse Reactions
Influence of cell cycle and oncogene activity upon topoisomerase IIalpha expression and drug toxicity.
Drug-Related Side Effects and Adverse Reactions
Multidrug resistance in leukaemia.
Drug-Related Side Effects and Adverse Reactions
Novel DNA topoisomerase II? inhibitors from combined ligand- and structure-based virtual screening.
Drug-Related Side Effects and Adverse Reactions
[Psychopathological syndromes in treatment with gyrase inhibitors]
Duodenal Ulcer
A comparison of two different doses of omeprazole versus ranitidine in treatment of duodenal ulcers.
Duodenal Ulcer
Effect of proximal gastric vagotomy on the activity of hydrogen, potassium-stimulated ATPase in the gastric mucosa of patients with duodenal ulcer.
Duodenal Ulcer
Intact long-type DupA protein in Helicobacter pylori is an ATPase involved in multifunctional biological activities.
Duodenal Ulcer
Pharmacological management of patients with peptic ulcer disease: prospects for the late 1980's.
Dwarfism
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Dysentery, Bacillary
MxiN Differentially Regulates Monomeric and Oligomeric Species of the Shigella Type Three Secretion System ATPase Spa47.
Dyskinesias
Abnormal movement of tropomyosin and response of myosin heads and actin during the ATPase cycle caused by the Arg167His, Arg167Gly and Lys168Glu mutations in TPM1 gene.
Dyslipidemias
Membrane Na+ K+ ATPase inhibition related dyslipidemia and insulin resistance in neuropsychiatric disorders.
Dystonia
Abnormal high-frequency burst firing of cerebellar neurons in rapid-onset dystonia-parkinsonism.
Dystonia
Generation of patient-specific induced pluripotent stem cell line (CSUi002-A) from a patient with isolated dystonia carrying TOR1A mutation.
Dystonia
Interaction of torsinA with its major binding partners is impaired by the dystonia-associated DeltaGAG deletion.
Dystonia
Novel mutations affecting the Na, K ATPase alpha model complex neurological diseases and implicate the sodium pump in increased longevity.
Dystonia
Twisting mice move the dystonia field forward.
Dystonia Musculorum Deformans
The Caenorhabditis elegans polarity gene ooc-5 encodes a Torsin-related protein of the AAA ATPase superfamily.
Dystonic Disorders
Regulation of Torsin ATPases by LAP1 and LULL1.
Dystonic Disorders
TorsinA hypofunction causes abnormal twisting movements and sensorimotor circuit neurodegeneration.
Eclampsia
Association of ATP2B1 gene polymorphism with incidence of eclampsia.
Elliptocytosis, Hereditary
[Improved hemolysis after splenectomy in a patient of hereditary elliptocytosis with increased Na flux and ATPase activity in red cell membranes]
Encephalitis, Japanese
Japanese encephalitis virus nonstructural protein NS3 has RNA binding and ATPase activities.
Encephalitis, Japanese
Role of the DExH motif of the Japanese encephalitis virus and hepatitis C virus NS3 proteins in the ATPase and RNA helicase activities.
Encephalitis, Japanese
Valosin-containing protein/p97 plays critical roles in the Japanese encephalitis virus life cycle.
Encephalomyelitis
WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism.
Encephalomyelitis, Autoimmune, Experimental
WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism.
Encephalomyelitis, Autoimmune, Experimental
[ATPase activity of the guinea pig central nervous system tissue with experimental allergic encephalomyelitis]
Endocarditis
4-Quinolone interactions with gyrase subunit B inhibitors.
Endodermal Sinus Tumor
Topoisomerase II alpha expression in testicular germ cell tumors.
Endometrial Neoplasms
Correlation between Topo II alpha expression and chemosensitivity testing for Topo II-targeting drugs in gynaecological carcinomas.
Endometrial Neoplasms
Effects of Slide Storage on Detection of Molecular Markers by IHC and FISH in Endometrial Cancer Tissues From a Clinical Trial: An NRG Oncology/GOG Pilot Study.
Endometrial Neoplasms
Evaluation of TOP2A as a Predictive Marker for Endometrial Cancer With Taxane-Containing Adjuvant Chemotherapy.
Endometrial Neoplasms
Identification of core genes in the progression of endometrial cancer and cancer cell-derived exosomes by an integrative analysis.
Endometrial Neoplasms
Immunohistochemical expression of topoisomerase IIalpha (Topo IIalpha) and multidrug resistance-associated protein (MRP), plus chemosensitivity testing, as chemotherapeutic indices of ovarian and endometrial carcinomas.
Endometriosis
Ecto-nucleotidases activities in the contents of ovarian endometriomas: potential biomarkers of endometriosis.
Endomyocardial Fibrosis
Digoxin and membrane sodium potassium ATPase inhibition in cardiovascular disease.
Endotoxemia
Atpase activity and palmitate oxidation of hepatic mitochondria in energy production in endotoxemia.
Endotoxemia
IOX1 activity as sepsis therapy and an antibiotic against multidrug-resistant bacteria.
Endotoxemia
[Na,K-ATPase activity of erythrocytes of rats during prolonged starvation].
Enteritis
[Ciprofloxacin in Salmonella infection and abdominal typhoid]
Ependymoma
A study of proliferative markers and tumor suppressor gene proteins in different grades of ependymomas.
Ependymoma
Ependymoma gene expression profiles associated with histological subtype, proliferation, and patient survival.
Ependymoma
Survivin expression in intracranial ependymomas and its correlation with tumor cell proliferation and patient outcome.
Epilepsies, Partial
Synaptosomal ATPase activities in temporal cortex and hippocampal formation of humans with focal epilepsy.
Epilepsy
A calcium signaling defect in the pathogenesis of a mitochondrial DNA inherited oxidative phosphorylation deficiency.
Epilepsy
Abnormalities of Na/K ATPase in migraine with aura.
Epilepsy
Alterations in cation levels and Na-K ATPase activity in rat cerebral cortex during the development of cobalt-induced epilepsy.
Epilepsy
ATPase N-ethylmaleimide-sensitive Fusion Protein: A Novel Key Player for Causing Spontaneous Network Excitation in Human Temporal Lobe Epilepsy.
Epilepsy
Blood tryptophan and ATPase in psychosis of epilepsy.
Epilepsy
Defective glutamate and K+ clearance by cortical astrocytes in familial hemiplegic migraine type 2.
Epilepsy
Differential effects of Na+/K+ ATPase blockade on cortical layer V neurons.
Epilepsy
Digoxin : a model for hypothalamic regulation of neuronal transmission, endocrine function, immunity and cytodifferentiation.
Epilepsy
Isolated Hearing Impairment Caused by SPATA5 Mutations in a Family with Variable Phenotypic Expression.
Epilepsy
Isoprenoid pathway and free radical generation and damage in neuropsychiatric disorders.
Epilepsy
Lack of association between temporal lobe epilepsy and a novel polymorphism in the alpha 2 subunit gene (ATP1A2) of the sodium potassium transporting ATPase.
Epilepsy
Na+K+ ATPase activity in the rat hippocampus: a study in the pilocarpine model of epilepsy.
Epilepsy
Predictors and mechanisms of epilepsy occurrence in cerebral gliomas: What to look for in clinicopathology.
Epilepsy
SPATA5 mutations cause a distinct autosomal recessive phenotype of intellectual disability, hypotonia and hearing loss.
Epilepsy, Generalized
No association between common variations in the human alpha 2 subunit gene (ATP1A2) of the sodium-potassium-transporting ATPase and idiopathic generalized epilepsy.
Epilepsy, Temporal Lobe
ATPase N-ethylmaleimide-sensitive Fusion Protein: A Novel Key Player for Causing Spontaneous Network Excitation in Human Temporal Lobe Epilepsy.
Epilepsy, Temporal Lobe
Lack of association between temporal lobe epilepsy and a novel polymorphism in the alpha 2 subunit gene (ATP1A2) of the sodium potassium transporting ATPase.
Epstein-Barr Virus Infections
[Regulation of immunoglobulin E synthesis]
Esophageal Neoplasms
Expression of ERCC1, TYMS, TUBB3, RRM1 and TOP2A in patients with esophageal squamous cell carcinoma: A hierarchical clustering analysis.
Esophageal Squamous Cell Carcinoma
Expression of ERCC1, TYMS, TUBB3, RRM1 and TOP2A in patients with esophageal squamous cell carcinoma: A hierarchical clustering analysis.
Esophageal Squamous Cell Carcinoma
Overexpression of ATPase Na+/+ transporting alpha 1 polypeptide, ATP1A1, correlates with clinical diagnosis and progression of esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
The prognostic significance of proliferative activity, apoptosis and expression of DNA topoisomerase II alpha in multimodally-treated oesophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Topoisomerase II alpha expression in esophageal squamous cell carcinoma.
Essential Hypertension
(Na+ + K+) ATPase inhibitors and intracellular electrolytes in essential hypertension.
Essential Hypertension
An increase in a circulating inhibitor of Na+,K+-dependent ATPase: a possible link between salt intake and the development of essential hypertension.
Essential Hypertension
Arguments for the presence of a Na-K ATPase pump inhibitor in the plasma of uremic and essential hypertensive patients.
Essential Hypertension
Cation fluxes and Na+-K+-activated ATPase activity in erythrocytes of patients with essential hypertension.
Essential Hypertension
Clinical study on the dephosphorylation of adenosine triphosphate by human sera, with special references to serum acid ATPase activity in essential hypertension.
Essential Hypertension
Comparative action of calpain on erythrocyte Ca2(+)-pumping ATPase in sickle cell anaemia, essential hypertension and kwashiorkor.
Essential Hypertension
Effect of dietary sodium on the Na-K ATPase inhibitor in patients with essential hypertension.
Essential Hypertension
Effects of ouabain on cytosolic calcium in lymphocytes, platelets and adrenomedullary cells.
Essential Hypertension
Erythrocyte and plasma Ca2+, Mg2+ and cell membrane adenosine triphosphatase activity in patients with essential hypertension.
Essential Hypertension
Erythrocyte membrane ouabain-sensitive Na+, K(+)-ATPase of hypertensive Nigerians.
Essential Hypertension
Evidence for a Na-K-ATPase-inhibitor in erythrocytes of patients with essential hypertension.
Essential Hypertension
Na-K-ATPase in erythrocyte ghosts is not a marker for primary hypertension.
Essential Hypertension
Platelet and erythrocyte Mg2+, Ca2+, Na+, K+ and cell membrane adenosine triphosphatase activity in essential hypertension in blacks.
Essential Hypertension
Relation of sodium-potassium adenosine triphosphatase inhibitor to sympathetic nervous system during salt-loading in essential hypertension.
Essential Hypertension
Short-term plasma renin activity suppression by saline and release of a plasma endogenous Na/K ATPase inhibitor in essential hypertension.
Essential Hypertension
Significant difference in the effect of acute saline loading on plasma Na-K ATPase inhibitor and blood pressure between children and adults with essential hypertension.
Essential Hypertension
Systemic Hypertension: The Roles of Salt, Vascular Na+/K+ ATPase and The Endogenous Glycosides, Ouabain and Marinobufagenin.
Essential Hypertension
[ATPase activity and sodium transport in erythrocytes of patients with essential hypertension (author's transl)]
Essential Hypertension
[Clinical study on the relationship between erythrocyte ATPase activity and lipid peroxidation in essential hypertension]
Essential Hypertension
[Cytochemical demonstration of an endogenous inhibitor of Na-K ATPase and its relationship to familial arterial hypertension]
Essential Hypertension
[Erythrocyte membrane abnormality of essential hypertension with special reference to membrane fluidity and Na(+)-K+ ATPase activity]
Extensively Drug-Resistant Tuberculosis
Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase.
Eye Diseases
Neuroprotective effects of VCP modulators in mouse models of glaucoma.
Fanconi Anemia
Acute myeloid leukaemia in children.
Fanconi Anemia
The synergistic proapoptotic effect of PARP-1 and HDAC inhibition in cutaneous T-cell lymphoma is mediated via Blimp-1.
Fanconi Anemia
TRAIP is a master regulator of DNA interstrand crosslink repair.
Fanconi Syndrome
Diseases of renal adenosine triphosphatase.
Fanconi Syndrome
Effect of ifosfamide metabolites on sodium-dependent phosphate transport in a model of proximal tubular cells (LLC-PK1) in culture.
Fanconi Syndrome
Role of adenosine triphosphate (ATP) and NaK ATPase in the inhibition of proximal tubule transport with intracellular cystine loading.
Fatty Liver
Ethanol induced metabolic alterations and the effect of phyllanthus niruri in their reversal.
Fatty Liver
Molecular properties of membrane lipids and activity of a membrane adenosine triphosphatase from Acholeplasma laidlawii B.
Favism
Favism: disordered erythrocyte calcium homeostasis.
Favism
Mechanisms of perturbation of erythrocyte calcium homeostasis in favism.
Fibroma
Enzyme histochemical study on bone tumors.
Fibroma
Prognostication of Soft Tissue Sarcomas Based on Chromosome 17q Gene and Protein Status: Evaluation of TOP2A, HER-2/neu, and Survivin.
Fibrosarcoma
Ameloblastic fibrosarcoma of the jaws--report of three cases. Clinico-pathologic, histoenzymological and ultrastructural study.
Fibrosarcoma
Aurintricarboxylic acid, a putative inhibitor of apoptosis, is a potent inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells.
Fibrosarcoma
HT1080/DR4: a P-glycoprotein-negative human fibrosarcoma cell line exhibiting resistance to topoisomerase II-reactive drugs despite the presence of a drug-sensitive topoisomerase II.
Fibrosarcoma
Potentiation of topoisomerase inhibitor-induced DNA strand breakage and cytotoxicity by tumor necrosis factor: enhancement of topoisomerase activity as a mechanism of potentiation.
Fibrosarcoma
Suramin is an inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells.
Fibrosarcoma
The antileukemic alkaloid fagaronine is an inhibitor of DNA topoisomerases I and II.
Flavivirus Infections
Small Molecule Inhibitor of ATPase Activity of HSP70 as a Broad-Spectrum Inhibitor against Flavivirus Infections.
Frontotemporal Dementia
Altered cofactor regulation with disease-associated p97/VCP mutations.
Frontotemporal Dementia
C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.
Frontotemporal Dementia
Enhanced ATPase activities as a primary defect of mutant valosin-containing proteins that cause inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia.
Frontotemporal Dementia
p97-containing complexes in proliferation control and cancer: emerging culprits or guilt by association?
Frontotemporal Dementia
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Fuchs' Endothelial Dystrophy
Moderate Fuchs' endothelial dystrophy ATPase pump site density.
Galactosemias
Abnormalities of retinal metabolism in diabetes or experimental galactosemia. III. Effects of antioxidants.
Galactosemias
Abnormalities of retinal metabolism in diabetes or galactosemia: ATPases and glutathione.
Gallbladder Neoplasms
Somatostatin elevates topoisomerase II alpha and enhances the cytotoxic effect of doxorubicin on gallbladder cancer cells.
Gallbladder Neoplasms
Topoisomerase II alpha promotes gallbladder cancer proliferation and metastasis through activating phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway.
Gallbladder Neoplasms
Upregulation of topoisomerase IIalpha expression in advanced gallbladder carcinoma: a potential chemotherapeutic target.
Gallstones
Changes in electrical potential difference of rectal mucosa and of gallbladder bile constituents of dogs fed chenodeoxycholic acid.
Ganglion Cysts
Role of DNA topoisomerase IIbeta in neurite outgrowth.
Gastric Fistula
Carbachol stimulation of gastric acid secretion and its effects on the parietal cell.
Gastritis
A convenient model of severe, high incidence autoimmune gastritis caused by polyclonal effector T cells and without perturbation of regulatory T cells.
Gastritis
A novel and effective approach of developing aggressive experimental autoimmune gastritis in neonatal thymectomized BALB/c mouse by polyinosinic:polycytidylic acid.
Gastritis
A T cell receptor transgenic model of severe, spontaneous organ-specific autoimmunity.
Gastritis
Alterations in the proliferating compartment of gastric mucosa during Helicobacter pylori infection: the putative role of epithelial cells expressing p27(kip1).
Gastritis
An autoimmune disease with multiple molecular targets abrogated by the transgenic expression of a single autoantigen in the thymus.
Gastritis
CD4+ T cells, but not CD8+ T cells, are required for the development of experimental autoimmune gastritis.
Gastritis
CD4+CD25+ Regulatory T Cells Inhibit the Antigen-Dependent Expansion of Self-Reactive T Cells In Vivo.
Gastritis
Contribution of epidemiological studies to gastritis immunology.
Gastritis
Control of T-cell activation by CD4+ CD25+ suppressor T cells.
Gastritis
Defining T cell receptors which recognise the immunodominant epitope of the gastric autoantigen, the H/K ATPase beta-subunit.
Gastritis
Diagnosis and classification of autoimmune gastritis.
Gastritis
Endogenous H/K ATPase beta-subunit promotes T cell tolerance to the immunodominant gastritogenic determinant.
Gastritis
Expression of a gastric autoantigen in pancreatic islets results in non-destructive insulitis after neonatal thymectomy.
Gastritis
Expression of the gastric H/K-ATPase alpha-subunit in the thymus may explain the dominant role of the beta-subunit in the pathogenesis of autoimmune gastritis.
Gastritis
GM-CSF-induced autoimmune gastritis in interferon alpha receptor deficient mice.
Gastritis
Helicobacter pylori, T cells and cytokines: the "dangerous liaisons".
Gastritis
Helios defines T cells being driven to tolerance in the periphery and thymus.
Gastritis
Identification of a gastritogenic epitope of the H/K ATPase beta-subunit.
Gastritis
Immunopathogenesis, loss of T cell tolerance and genetics of autoimmune gastritis.
Gastritis
Immunopathology of autoimmune gastritis: lessons from mouse models.
Gastritis
Local transgenic expression of granulocyte macrophage-colony stimulating factor initiates autoimmunity.
Gastritis
Mucosal enzyme patterns in gastric epithelial disease.
Gastritis
Pathophysiology and laboratory diagnosis of pernicious anemia.
Gastritis
Post-thymectomy autoimmune gastritis: fine specificity and pathogenicity of anti-H/K ATPase-reactive T cells.
Gastritis
Prevention of autoimmune gastritis in mice requires extra-thymic T-cell deletion and suppression by regulatory T cells.
Gastritis
Tolerance and autoimmunity to a gastritogenic peptide in TCR transgenic mice.
Gastritis
Transient systemic inflammation does not alter the induction of tolerance to gastric autoantigens by migratory dendritic cells.
Gastritis, Atrophic
Mucosal enzyme patterns in gastric epithelial disease.
Gastritis, Atrophic
Variations of energy metabolism and adenosine triphosphatase activity in gastric mucosa in chronic atrophic gastritis rats with Qi deficiency and blood stasis syndrome and effect of zhiweifangbian capsule.
Gastroenteritis
[Cardiomyocyte myosin heavy chain composition change after cryptosporidial gastroenteritis].
Gastrointestinal Neoplasms
Growth inhibition of human gastrointestinal cancer xenograft lines by treatment with CPT-11 and VP-16.
Gastrointestinal Stromal Tumors
Gastrointestinal stromal tumors - quantitative detection of the Ki-67, TPX2, TOP2A, and hTERT telomerase subunit mRNA levels to determine a proliferation activity and a potential for aggressive biological behavior.
Gastrointestinal Stromal Tumors
Inhibition of AKT-Signaling Sensitizes Soft Tissue Sarcomas (STS) and Gastrointestinal Stromal Tumors (GIST) to Doxorubicin via Targeting of Homology-Mediated DNA Repair.
Gastrointestinal Stromal Tumors
Inhibition of FGFR2-Signaling Attenuates a Homology-Mediated DNA Repair in GIST and Sensitizes Them to DNA-Topoisomerase II Inhibitors.
Gastrointestinal Stromal Tumors
Inhibition of fibroblast growth factor receptor-signaling sensitizes imatinib-resistant gastrointestinal stromal tumors to low doses of topoisomerase II inhibitors.
Genetic Diseases, Inborn
Chelating polymeric beads as potential therapeutics for Wilson's disease.
Genetic Diseases, Inborn
Ion efflux systems involved in bacterial metal resistances.
Genetic Diseases, Inborn
Structural and Functional Analysis of Disease-Linked p97 ATPase Mutant Complexes.
Genetic Diseases, Inborn
The aleu207-->arg mutation in F1F0-ATP synthase from Escherichia coli. A model for human mitochondrial disease.
Genetic Diseases, Inborn
The ATPase SRCAP is associated with the mitotic apparatus, uncovering novel molecular aspects of Floating-Harbor syndrome.
Genetic Diseases, Inborn
[Biological regulation of copper and selective removal of copper: therapy for Wilson disease and its molecular mechanism]
Giant Cell Tumors
Enzyme histochemical study on bone tumors.
Giant Cell Tumors
[Histogenesis of giant cell tumors of bone. comparative, ultrastructural and histo-enzymologic study of osteoforming tumors and malignant and giant cell tumors]
Gilbert Disease
Camptothecin and Podophyllotoxin Derivatives : Inhibitors of Topoisomerase I and II - Mechanisms of Action, Pharmacokinetics and Toxicity Profile.
Glaucoma
Higher Reliance on Glycolysis Limits Glycolytic Responsiveness in Degenerating Glaucomatous Optic Nerve.
Glaucoma
Neuroprotective effects of VCP modulators in mouse models of glaucoma.
Glaucoma
The DNA topoisomerase II inhibitor amsacrine as a novel candidate adjuvant in a model of glaucoma filtration surgery.
Glioblastoma
Characterization of gene expression profiles associated with glioma progression using oligonucleotide-based microarray analysis and real-time reverse transcription-polymerase chain reaction.
Glioblastoma
Comparison of the effect of three different topoisomerase II inhibitors combined with cisplatin in human glioblastoma cells sensitized with double strand break repair inhibitors.
Glioblastoma
Drug resistance-associated factors in primary and secondary glioblastomas and their precursor tumors.
Glioblastoma
Etoposide-mediated glioblastoma cell death: dependent or independent on the expression of its target, topoisomerase II alpha?
Glioblastoma
High expression of DNA topoisomerase IIalpha and Ki-67 antigen is associated with prolonged survival in glioblastoma patients.
Glioblastoma
Higher LRRFIP1 expression in glioblastoma multiforme is associated with better response to teniposide, a type II topoisomerase inhibitor.
Glioblastoma
Higher topoisomerase 2 alpha gene transcript levels predict better prognosis in GBM patients receiving temozolomide chemotherapy: identification of temozolomide as a TOP2A inhibitor.
Glioblastoma
Identification of potential key genes associated with glioblastoma based on the gene expression profile.
Glioblastoma
Immunohistochemical staining of DNA topoisomerase IIalpha in human gliomas.
Glioblastoma
In situ detection of telomeres by fluorescence in situ hybridization and telomerase activity in glioblastoma multiforme: correlation with p53 status, EGFR, c-myc, MIB1, and Topoisomerase IIalpha protein expression.
Glioblastoma
MIB-1 and DNA topoisomerase II alpha could be helpful for predicting long-term survival of patients with glioblastoma.
Glioblastoma
Mitochondrial protein ATPase family, AAA domain containing 3A correlates with radioresistance in glioblastoma.
Glioblastoma
Na+/K+-ATPase Revisited: On Its Mechanism of Action, Role in Cancer, and Activity Modulation.
Glioblastoma
Proscillaridin A is cytotoxic for glioblastoma cell lines and controls tumor xenograft growth in vivo.
Glioblastoma
Quantitative analysis of topoisomerase II alpha and evaluation of its effects on cell proliferation and apoptosis in glioblastoma cancer stem cells.
Glioblastoma
Reverse engineering of modified genes by bayesian network analysis defines molecular determinants critical to the development of glioblastoma.
Glioblastoma
The Inhibition of miR-144-3p on Cell Proliferation and Metastasis by Targeting TOP2A in HCMV-Positive Glioblastoma Cells.
Glioblastoma
The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma.
Glioblastoma
Topoisomerase II inhibition and altered kinetics of formation and repair of nitrosourea and cisplatin-induced DNA interstrand cross-links and cytotoxicity in human glioblastoma cells.
Glioblastoma
Topoisomerase II Poisons for Glioblastoma; Existing Challenges and Opportunities to Personalize Therapy.
Glioblastoma
Valproic acid induces p21 and topoisomerase-II (alpha/beta) expression and synergistically enhances etoposide cytotoxicity in human glioblastoma cell lines.
Glioblastoma
[Difference in 201TlCl accumulation mechanism in brain tumors: a comparison of their Na(+)-K+ ATPase activities]
Glioma
A Menkes P-type ATPase involved in copper homeostasis in the central nervous system of the rat.
Glioma
Anticancer activity of dihydropyrazolo[1,5-c]quinazolines against rat C6 glioma cells via inhibition of topoisomerase II.
Glioma
ATPase inhibitory factor 1 is a potential prognostic marker for the migration and invasion of glioma.
Glioma
Brg1 mutation alters oxidative stress responses in glioblastoma.
Glioma
Ceramide triggers caspase activation during gamma-radiation-induced apoptosis of human glioma cells lacking functional p53.
Glioma
Comparison of the effect of three different topoisomerase II inhibitors combined with cisplatin in human glioblastoma cells sensitized with double strand break repair inhibitors.
Glioma
Convection-enhanced delivery of etoposide is effective against murine proneural glioblastoma.
Glioma
Copper efflux from murine microvascular cells requires expression of the menkes disease Cu-ATPase.
Glioma
Digoxin : a model for hypothalamic regulation of neuronal transmission, endocrine function, immunity and cytodifferentiation.
Glioma
DIVERSet JAG Compounds Inhibit Topoisomerase II and Are Effective Against Adult and Pediatric High-Grade Gliomas.
Glioma
DNA topoisomerase II-alpha as a proliferation marker in human gliomas: correlation with PCNA expression and patient survival.
Glioma
DNA topoisomerase IIalpha and Her-2/neu gene dosages in pediatric malignant gliomas.
Glioma
DNA topoisomerase IIalpha expression in optic pathway gliomas of childhood.
Glioma
DNA topoisomerase IIalpha predicts progression-free and overall survival in pediatric malignant non-brainstem gliomas.
Glioma
Drug-resistance gene expression and progression of astrocytic tumors.
Glioma
Etoposide sensitivity of radioresistant human glioma cell lines.
Glioma
GL331, a topoisomerase II inhibitor, induces radiosensitization of human glioma cells.
Glioma
High topoisomerase IIalpha expression associates with high proliferation rate and and poor prognosis in oligodendrogliomas.
Glioma
Higher topoisomerase 2 alpha gene transcript levels predict better prognosis in GBM patients receiving temozolomide chemotherapy: identification of temozolomide as a TOP2A inhibitor.
Glioma
Identification of potassium flux pathways and their role in the cytotoxicity of estramustine in human malignant glioma, prostatic carcinoma and pulmonary carcinoma cell lines.
Glioma
Immunohistochemical staining of DNA topoisomerase IIalpha in human gliomas.
Glioma
In vivo etoposide-resistant C6 glioma cell line: significance of altered DNA topoisomerase II activity in multi-drug resistance.
Glioma
Increase in secretion of glial cell line-derived neurotrophic factor from glial cell lines by inhibitors of vacuolar ATPase.
Glioma
Increased phosphorylation of DNA topoisomerase II in etoposide resistant mutants of human glioma cell line.
Glioma
Induction of apoptosis and cell cycle arrest in glioma cells by GL331 (a topoisomerase II inhibitor).
Glioma
Induction of resistance to etoposide and adriamycin in a human glioma cell line treated with antisense oligodeoxynucleotide complementary to the messenger ribonucleic acid of deoxyribonucleic acid topoisomerase II alpha.
Glioma
Inhibition of topoisomerase II alpha subunit de novo synthesis by specific antisense oligonucleotides suppresses human glioma T98G cell growth.
Glioma
Inhibitory effects of lapachol on rat C6 glioma in vitro and in vivo by targeting DNA topoisomerase I and topoisomerase II.
Glioma
Interplay Between V-ATPase G1 and Small EV-miRNAs Modulates ERK1/2 Activation in GBM Stem Cells and Nonneoplastic Milieu.
Glioma
MicroRNA-9 enhances chemotherapy sensitivity of glioma to TMZ by suppressing TOPO II via the NF-?B signaling pathway.
Glioma
Neonatal rotenone lesions cause onset of hyperactivity during juvenile and adulthood in the rat.
Glioma
Oncogenic effects of evolutionarily conserved noncoding RNA ECONEXIN on gliomagenesis.
Glioma
Over-expression of TOP2A as a prognostic biomarker in patients with glioma.
Glioma
Predictors and mechanisms of epilepsy occurrence in cerebral gliomas: What to look for in clinicopathology.
Glioma
Quantitative analysis of topoisomerase IIalpha to rapidly evaluate cell proliferation in brain tumors.
Glioma
Quantitative Proteomic Profiling of Tachyplesin I Targets in U251 Gliomaspheres.
Glioma
Rapid inhibition of ongoing DNA synthesis in human glioma tissue by genistein.
Glioma
Resistance to topoisomerase II inhibitors in human glioma cell lines overexpressing multidrug resistant associated protein (MRP) 2.
Glioma
Resveratrol acts as a topoisomerase II poison in human glioma cells.
Glioma
Sequence of a Menkes-type Cu-transporting ATPase from rat C6 glioma cells: comparison of the rat protein with other mammalian Cu-transporting ATPases.
Glioma
Specific gene suppression using antisense strategy for growth suppression of glioma.
Glioma
Stiff person syndrome and other immune-mediated movement disorders - new insights.
Glioma
Synergistic augmentation of antimicrotubule agent-induced cytotoxicity by a phosphoinositide 3-kinase inhibitor in human malignant glioma cells.
Glioma
Synergistic cytotoxicity, apoptosis and protein-linked DNA breakage by etoposide and camptothecin in human U87 glioma cells: dependence on tyrosine phosphorylation.
Glioma
T98G glioma cells have nicks in DNA in quiescent phase.
Glioma
The ATPase Pontin is a key cell cycle regulator by amplifying E2F1 transcription response in glioma.
Glioma
The Inhibition of miR-144-3p on Cell Proliferation and Metastasis by Targeting TOP2A in HCMV-Positive Glioblastoma Cells.
Glioma
The topoisomerase II inhibitor, genistein, induces G2/M arrest and apoptosis in human malignant glioma cell lines.
Glioma
TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas.
Glioma
Transcriptome analysis revealed CENPF associated with glioma prognosis.
Glioma
[Correlation between DNA topoisomerase II alpha expression and sensitivity to etoposide in human glioma cell lines]
Glioma
[Difference in 201TlCl accumulation mechanism in brain tumors: a comparison of their Na(+)-K+ ATPase activities]
Glioma
[Effects of phenobarbital and phenytoin on the growth morphology and some ATPase activities of rat brain astrocytes derived from normal newborn cerebrum and C6 glioma cells in culture]
Glioma
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Glioma
[Sensitivity to etoposide of human malignant glioma cell lines. Mechanisms of action]
Glioma, Subependymal
Ependymoma gene expression profiles associated with histological subtype, proliferation, and patient survival.
Glomerulonephritis
Enzyme histochemistry in plastic-embedded sections of normal and diseased kidneys.
Glomerulonephritis
Expression of DNA topoisomerases in chronic proliferative kidney disease.
Glomerulonephritis
Increased expression of glomerular mesangial cell 5'-nucleotidase in membranous nephropathy.
Glomerulonephritis, Membranoproliferative
Expression of DNA topoisomerases in chronic proliferative kidney disease.
Glomerulonephritis, Membranous
Expression of DNA topoisomerases in chronic proliferative kidney disease.
Glomus Tumor
Histochemical evidence of adenosine triphosphatase activity in glomus tumor--report of a case.
Glucose Intolerance
Abnormal cation exchange in insulin-resistant patients with essential hypertension.
Glucose Intolerance
Nutrient-gene interactions in mitochondrial function: vitamin A needs are increased in BHE/Cdb rats.
Glucose Intolerance
Role of vitamin A in mitochondrial gene expression.
Glucose Intolerance
The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet ?-Cell Function.
glucose-6-phosphatase deficiency
The role of hyperplastic nodules in dichloroacetic acid-induced hepatocarcinogenesis in B6C3F1 male mice.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Calcium activated neutral protease & calcium ATPase in glucose-6-phosphate dehydrogenase deficiency hemizygotes.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Erythrocyte membrane ATPase activity of G6PD-deficient individuals and the effect of primaquine metabolite(s) on membrane ATPase enzymes.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
[A family study of G-6-PD deficiency associated with increased erythrocyte ATPase activities and reduced blood ATP levels]
Glucosephosphate Dehydrogenase Deficiency
Calcium activated neutral protease & calcium ATPase in glucose-6-phosphate dehydrogenase deficiency hemizygotes.
Glucosephosphate Dehydrogenase Deficiency
Erythrocyte membrane ATPase activity of G6PD-deficient individuals and the effect of primaquine metabolite(s) on membrane ATPase enzymes.
glutamate-5-semialdehyde dehydrogenase deficiency
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Glycogen Storage Disease Type I
The role of hyperplastic nodules in dichloroacetic acid-induced hepatocarcinogenesis in B6C3F1 male mice.
Gonorrhea
A Cost Analysis of Gyrase A Testing and Targeted Ciprofloxacin Therapy Versus Recommended 2-Drug Therapy for Neisseria gonorrhoeae Infection.
Gonorrhea
Comparison of minimum inhibitory concentration results for gepotidacin obtained using agar dilution and broth microdilution methods.
Gonorrhea
Genetic Resistance Determinants, In Vitro Time-Kill Curve Analysis and Pharmacodynamic Functions for the Novel Topoisomerase II Inhibitor ETX0914 (AZD0914) in Neisseria gonorrhoeae.
Gonorrhea
Gepotidacin for the Treatment of Uncomplicated Urogenital Gonorrhea: A Phase 2, Randomized, Dose-Ranging, Single-Oral Dose Evaluation.
Gonorrhea
High in vitro activity of the novel spiropyrimidinetrione AZD0914, a DNA gyrase inhibitor, against multidrug-resistant Neisseria gonorrhoeae isolates suggests a new effective option for oral treatment of gonorrhea.
Gonorrhea
Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914.
Gonorrhea
Multicenter Investigation of Gepotidacin (GSK2140944) Agar Dilution Quality Control Determinations for Neisseria gonorrhoeae ATCC 49226.
Gonorrhea
Resistance-Guided Treatment of Gonorrhea: A Prospective Clinical Study.
Granulomatous Disease, Chronic
The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.
Graves Disease
Na+, K+ ATPase activity in red cells predicts the recurrence of hyperthyroidism in patients with Graves' disease.
Graves Disease
Na-K-dependent ATPase in red cells and thyroid status.
Graves Disease
p27kip1 expression distinguishes papillary hyperplasia in Graves' disease from papillary thyroid carcinoma.
Graves Disease
[Clinical studies on assay for Na-K ATPase in human blood cells. I. Erythrocyte Na-K ATPase assay in patients with thyroid dysfunction and in those with chronic renal failure]
Head and Neck Neoplasms
Evaluation of pemetrexed and etoposide as therapeutic regimens for human papillomavirus-positive oral and oropharyngeal cancer.
Head and Neck Neoplasms
The influence of hyaluronan-CD44 interaction on topoisomerase II activity and etoposide cytotoxicity in head and neck cancer.
Head and Neck Neoplasms
Topoisomerase II alpha expression in squamous cell carcinomas of the head and neck.
Hearing Loss
Genotype-phenotype correlation in MYH9-related thrombocytopenia.
Hearing Loss
Isolated Hearing Impairment Caused by SPATA5 Mutations in a Family with Variable Phenotypic Expression.
Hearing Loss
Mutations in TOP2B cause autosomal-dominant hereditary hearing loss via inhibition of the PI3K-Akt signalling pathway.
Hearing Loss
SPATA5 mutations cause a distinct autosomal recessive phenotype of intellectual disability, hypotonia and hearing loss.
Heart Arrest
ECMO attenuates inflammation response and increases ATPase activity in brain of swine model with cardiac arrest compared with CCPR.
Heart Arrest
Effect of crystalloid cardioplegia and verapamil on cardiac function and cellular biochemistry during hypothermic cardiac arrest.
Heart Arrest
Effect of hypertransfusion on the gastrointestinal tract after cardiac arrest in a porcine model.
Heart Arrest
Effects of blood and crystalloid cardioplegia on cardiac function at organ and cellular levels during hypothermic cardiac arrest.
Heart Arrest
Effects of diltiazem on the functional recovery of the myocardium at organ and cellular level during prolonged hypothermic ischemic cardiac arrest.
Heart Arrest
[Effects of mild hypothermia on Na(+)-K+ ATPase and lipid peroxidation in canine brain tissue following cardiac arrest and resuscitation]
Heart Defects, Congenital
Isoforms of troponin in normal and diseased myocardium.
Heart Diseases
Early alterations in the function of sarcoplasmic reticulum in a naturally occurring model of congestive cardiomyopathy.
Heart Diseases
Molecular targets in heart failure gene therapy: current controversies and translational perspectives.
Heart Diseases
Studies on ultrastructure and cytochemical ATPase activity in human cardiac myocytes from biopsies from patients with various heart diseases.
Heart Diseases
Zebrafish chemical screening reveals the impairment of dopaminergic neuronal survival by cardiac glycosides.
Heart Failure
AAV-mediated knockdown of phospholamban leads to improved contractility and calcium handling in cardiomyocytes.
Heart Failure
Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure.
Heart Failure
Alterations in the activity of cardiac Na + -K + -stimulated ATPase in congestive heart failure.
Heart Failure
Altered expression of troponin T isoforms in mild left ventricular hypertrophy in the rabbit.
Heart Failure
Altered sarcolemmal calcium channel density and Ca(2+)-pump ATPase activity in tachycardia heart failure.
Heart Failure
Ameliorated stress related proteins are associated with improved cardiac function by sarcoplasmic reticulum calcium ATPase gene transfer in heart failure.
Heart Failure
ATPase may play a critical role in disturbance of energy metabolism in congestive heart failure rats.
Heart Failure
Attenuation of Endoplasmic Reticulum Stress-Related Myocardial Apoptosis by SERCA2a Gene Delivery in Ischemic Heart Disease.
Heart Failure
Augmented venous return: protection of the ischemic myocardium during endotoxemia.
Heart Failure
Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak.
Heart Failure
Brain "ouabain", a neurosteroid, mediates sympathetic hyperactivity in salt-sensitive hypertension.
Heart Failure
Ca handling during excitation-contraction coupling in heart failure.
Heart Failure
CaMKII?B mediates aberrant NCX1 expression and the imbalance of NCX1/SERCA in transverse aortic constriction-induced failing heart.
Heart Failure
Cardiac contractile proteins in hypertrophied and failing guinea pig heart.
Heart Failure
Cardiac intracellular and blood electrolytes in chronic mitral insufficiency.
Heart Failure
Cardiac myofibrillar ATPase and electrophoretic pattern in experimental heart failure produced by a two-step mechanical overloading in the rat.
Heart Failure
Cardiomyocyte-specific disruption of Serca2 in adult mice causes sarco(endo)plasmic reticulum stress and apoptosis.
Heart Failure
Catecholamine-stimulated potassium transport in erythrocytes from normal and obese subjects.
Heart Failure
Changes in Ca(2+) cycling proteins underlie cardiac action potential prolongation in a pressure-overloaded guinea pig model with cardiac hypertrophy and failure.
Heart Failure
Combining SERCA2a activation and Na-K ATPase inhibition: a promising new approach to managing acute heart failure syndromes with low cardiac output.
Heart Failure
Comparison of heart sarcolemmal enzyme activities in normal and cardiomyopathic (UM-X7.1) hamsters.
Heart Failure
Crystal structure of the sodium-potassium pump (Na+,K+-ATPase) with bound potassium and ouabain.
Heart Failure
Decreased expression of cardiac sarcoplasmic reticulum Ca(2+)-pump ATPase in congestive heart failure due to myocardial infarction.
Heart Failure
Depression of force production and ATPase activity in different types of human skeletal muscle fibers from patients with chronic heart failure.
Heart Failure
Design of a Phase 2b Trial of Intracoronary Administration of AAV1/SERCA2a in Patients With Advanced Heart Failure: The CUPID 2 Trial (Calcium Up-Regulation by Percutaneous Administration of Gene Therapy in Cardiac Disease Phase 2b).
Heart Failure
Discovery and Structural Characterization of a Phospholamban-Binding Cyclic Peptide and Design of Novel Inhibitors of Phospholamban.
Heart Failure
Early alterations in the function of sarcoplasmic reticulum in a naturally occurring model of congestive cardiomyopathy.
Heart Failure
Effect of intracoronary administration of AAV1/SERCA2a on ventricular remodelling in patients with advanced systolic heart failure: results from the AGENT-HF randomized phase 2 trial.
Heart Failure
Effects of triiodo-thyronine on angiotensin-induced cardiomyocyte hypertrophy: reversal of increased beta-myosin heavy chain gene expression.
Heart Failure
Endothelin receptor antagonist CPU0213 and vitamin E reverse downregulation of FKBP12.6 and SERCA2a: a role of hyperphosphorylation of PKCepsilon.
Heart Failure
Endotoxin and myocardial failure: role of the myofibril and venous return.
Heart Failure
Experimental congestive heart failure due to myocardial infarction: sarcolemmal receptors and cation transporters.
Heart Failure
Expression of sarco (endo) plasmic reticulum calcium ATPase (SERCA) system in normal mouse cardiovascular tissues, heart failure and atherosclerosis.
Heart Failure
Heart failure leads to altered ?2-adrenoceptor/cyclic adenosine monophosphate dynamics in the sarcolemmal phospholemman/Na,K ATPase microdomain.
Heart Failure
Human myocardial adenosine triphosphatase activities in health and heart failure.
Heart Failure
Identification of a protein phosphatase-1/phospholamban complex that is regulated by cAMP-dependent phosphorylation.
Heart Failure
Identification of the molecular basis of doxorubicin-induced cardiotoxicity.
Heart Failure
Immunosuppression Decreases Inflammation and Increases AAV6-hSERCA2a-Mediated SERCA2a Expression.
Heart Failure
Impairment of mitochondrial and sarcoplasmic reticular functions during the development of heart failure in cardiomyopathic (UM-X7.1) hamsters.
Heart Failure
Improvement in cardiac function after sarcoplasmic reticulum Ca2+-ATPase gene transfer in a beagle heart failure model.
Heart Failure
In vitro selection and characterization of DNA aptamers specific for phospholamban.
Heart Failure
In vivo adenoviral transfer of sorcin reverses cardiac contractile abnormalities of diabetic cardiomyopathy.
Heart Failure
Istaroxime: a new luso-inotropic agent for heart failure.
Heart Failure
Long-term levosimendan treatment improves systolic function and myocardial relaxation in mice with cardiomyocyte-specific disruption of the SERCA2 gene.
Heart Failure
Maximal actomyosin ATPase activity and in vitro myosin motility are unaltered in human mitral regurgitation heart failure.
Heart Failure
Maximal ATPase activity and calcium sensitivity of reconstituted myofilaments are unaltered by the fetal troponin T re-expressed during human heart failure.
Heart Failure
Metabolic control of contractile performance in isolated perfused rat heart. Analysis of experimental data by reaction:diffusion mathematical model.
Heart Failure
Modulation of baroreflex and baroreceptor function in experimental heart failure.
Heart Failure
Molecular targets in heart failure gene therapy: current controversies and translational perspectives.
Heart Failure
Myocardial myoglobin deficiency in various animal models of congestive heart failure.
Heart Failure
Na+/K+ ATPase inhibitors in cancer.
Heart Failure
Observations on atrial natriuretic peptide, sympathetic activity and renal Ca2+ pump in diabetic and hypertensive rats.
Heart Failure
Overexpression of Sarcoendoplasmic Reticulum Calcium ATPase 2a Promotes Cardiac Sympathetic Neurotransmission via Abnormal Endoplasmic Reticulum and Mitochondria Ca(2+) Regulation.
Heart Failure
Perturbation of microRNAs in Rat Heart during Chronic Doxorubicin Treatment.
Heart Failure
Pharmacological modulation of cardiac and vascular contractile protein function.
Heart Failure
Pharmacology of the cardiac sarcoplasmic reticulum calcium ATPase-phospholamban interaction.
Heart Failure
Recirculating cardiac delivery of AAV2/1SERCA2a improves myocardial function in an experimental model of heart failure in large animals.
Heart Failure
Reduced cardiac myofibrillar Mg-ATPase activity without changes in myosin isozymes in patients with end-stage heart failure.
Heart Failure
Reduced pH and contractility in failing rat cardiomyocytes.
Heart Failure
Rescuing the failing heart by targeted gene transfer.
Heart Failure
Reversal of cardiac dysfunction after long-term expression of SERCA2a by gene transfer in a pre-clinical model of heart failure.
Heart Failure
Sarcoendoplasmic reticulum calcium transport ATPase 2a: a potential gene therapy target in heart failure.
Heart Failure
Sarcoplasmic reticular Ca2+ pump ATPase activity in congestive heart failure due to myocardial infarction.
Heart Failure
Sarcoplasmic reticulum Ca(2+) ATPase as a therapeutic target for heart failure.
Heart Failure
SERCA2a Gene Transfer Decreases SR Calcium Leak and Reduces Ventricular Arrhythmias in a Model of Chronic Heart Failure.
Heart Failure
Statins in anthracycline-induced cardiotoxicity: Rac and Rho, and the heartbreakers.
Heart Failure
Structural and functional diversity of human ventricular myosin.
Heart Failure
Subcellular mechanisms underlying digitalis-induced arrhythmias: role of calcium/calmodulin-dependent kinase II (CaMKII) in the transition from an inotropic to an arrhythmogenic effect.
Heart Failure
The relation of membrane-ATPase activity with congestive heart failure.
Heart Failure
Transgenic expression of sarcoplasmic reticulum Ca(2+) atpase modifies the transition from hypertrophy to early heart failure.
Heart Failure
[Antagonism for different doses of taurine on calcium overload in myocardial cells of diastole heart failure rat model]
Heart Failure
[Cardiomyocyte myosin heavy chain composition change after cryptosporidial gastroenteritis].
Heart Failure
[Myocardial myofibrillary ATPase in cardiac failure]
Heart Failure
[Research progress of sarcolipin-a new regulatory protein of sarcoplasmic reticulum Ca2+ ATPase].
Heart Neoplasms
[Differential expression of immunohistochemical markers between cardiac carcinoma and carcinoma in antrum of stomach and correlation thereof with clinicopathological factors]
Heart Valve Diseases
Analysis of azide-insensitive Ca2+-dependent ATPase activity in atrial specimens from patients with coronary or valvular heart disease.
Heart Valve Diseases
Relationship between the myofibrillar ATPase activity of human biopsy material and hemodynamic parameters.
Hemangiopericytoma
Intracranial hemangiopericytomas: correlation of topoisomerase IIalpha expression with biologic behavior.
Hemangiopericytoma
[Immunohistochemical evaluation of intracranial recurrent meningiomas: correlation of topoisomerase II alpha expression and cell proliferative potential]
Hematologic Neoplasms
A case of treatment-related myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemotherapy with autologous stem cell transplantation for non-Hodgkin's lymphoma.
Hematologic Neoplasms
DNA Topoisomerase II-alpha as a marker of cell proliferation in endocrine and other neoplasms.
Hematologic Neoplasms
Fusion of the nucleoporin gene, NUP98, and the putative RNA helicase gene, DDX10, by inversion 11 (p15q22) chromosome translocation in a patient with etoposide-related myelodysplastic syndrome.
Hematologic Neoplasms
Immunohistochemical detection of P glycoprotein, glutathione S transferase and DNA topoisomerase II in human tumors.
Hematologic Neoplasms
Mechanism of action of DNA topoisomerase inhibitors.
Hematologic Neoplasms
Mechanisms regulating resistance to inhibitors of topoisomerase II.
Hematologic Neoplasms
S-1 induced secondary acute erythroid leukemia with a chromosome inv(12)(p13;q13).
Hematologic Neoplasms
Sensitivity to TOP2 Targeting Chemotherapeutics Is Regulated by Oct1 and FILIP1L.
Hematologic Neoplasms
T-cell acute lymphoblastic leukemia as a secondary leukemia after a 3-year remission of acute myelocytic leukemia.
Hematologic Neoplasms
Therapy-related acute promyelocytic leukemia: a report on 16 cases.
Hematologic Neoplasms
Therapy-related acute promyelocytic leukemia: a systematic review.
Hematologic Neoplasms
Tumor p53 status and response to topoisomerase II inhibitors.
Hematologic Neoplasms
[Epigenetic effects affecting etoposide distribution and metabolism in the human body].
Hemiplegia
A functional correlate of severity in alternating hemiplegia of childhood.
Hemiplegia
ATP1A3-Encoded Sodium-Potassium ATPase Subunit Alpha 3 D801N Variant Is Associated With Shortened QT Interval and Predisposition to Ventricular Fibrillation Preceded by Bradycardia.
Hemochromatosis
Recent advance in the molecular genetics of Wilson disease and hereditary hemochromatosis.
Hemoglobinopathies
[Changes in ATPase activity and in erythrocyte cation (Na, K) content in hemoglobinopathies in children]
Hemorrhagic Fever with Renal Syndrome
[Clinico-diagnostic evaluation of changes in ATPase activity, lipid peroxidation and stability of red cell membranes in patients suffering from hemorrhagic fever with renal syndrome]
Hepatitis
Coronavirus interactions with the cellular autophagy machinery.
Hepatitis
RNA-Stimulated ATPase and RNA helicase activities and RNA binding domain of hepatitis G virus nonstructural protein 3.
Hepatitis
Solution structure of the C-terminal antiparallel coiled-coil domain from Escherichia coli osmosensor ProP.
Hepatitis
[Comparative characteristics of adenosine triphosphatase activity in the erythrocytes of patients with acute and chronic liver diseases, chronic cholecystitis and in HBs antigen carriers]
Hepatitis
[Differential, diagnostic value of determination of total ATPase in the erythrocytes in acute and chronic viral hepatitis, liver cirrhosis and obstructive jaundice]
Hepatitis
[Effect of splenin on the liver, spleen, and kidney ATPase activity of rats with experimental hepatitis]
Hepatitis A
SMAD3 promotes autophagy dysregulation by triggering lysosome depletion in tubular epithelial cells in diabetic nephropathy.
Hepatitis B
Daunorubicin, a topoisomerase II poison, suppresses viral production of hepatitis B virus by inducing cGAS-dependent innate immune response.
Hepatitis B
Hepatitis B Virus Oncoprotein HBx Is Not an ATPase.
Hepatitis B
Statistical analysis of physical-chemical properties and prediction of protein-protein interfaces.
Hepatitis B
The X protein of hepatitis B virus has a ribo/deoxy ATPase activity.
Hepatitis B
TOP2A Amplification and Overexpression in Hepatocellular Carcinoma Tissues.
Hepatitis B, Chronic
The effect of interferon therapy on erythrocyte membrane Na+,K+ ATP activity in patients with chronic hepatitis B and C virus infections.
Hepatitis C
A Brownian motor mechanism of translocation and strand separation by hepatitis C virus helicase.
Hepatitis C
A homeopathic nosode, Hepatitis C 30 demonstrates anticancer effect against liver cancer cells in vitro by modulating telomerase and topoisomerase II activities as also by promoting apoptosis via intrinsic mitochondrial pathway.
Hepatitis C
A kinetic analysis of the oligonucleotide-modulated ATPase activity of the helicase domain of the NS3 protein from hepatitis C virus. The first cycle of interaction of ATP with the enzyme is unique.
Hepatitis C
Aggregation of a hepatitis C virus replicase module induced by ablation of p97/VCP.
Hepatitis C
Amantadine and rimantadine have no direct inhibitory effects against hepatitis C viral protease, helicase, ATPase, polymerase, and internal ribosomal entry site-mediated translation.
Hepatitis C
Characterization of ATPase activity of a hepatitis C virus NS3 helicase domain, and analysis involving mercuric reagents.
Hepatitis C
Crystal structure of the ATPase domain of translation initiation factor 4A from Saccharomyces cerevisiae--the prototype of the DEAD box protein family.
Hepatitis C
Functional and topological properties in hepatocellular carcinoma transcriptome.
Hepatitis C
Hepatitis C virus NS3 RNA helicase activity is modulated by the two domains of NS3 and NS4A.
Hepatitis C
Inhibition of the hepatitis C virus helicase-associated ATPase activity by the combination of ADP, NaF, MgCl2, and poly(rU). Two ADP binding sites on the enzyme-nucleic acid complex.
Hepatitis C
Kinetic analysis of the effects of mutagenesis of W501 and V432 of the hepatitis C virus NS3 helicase domain on ATPase and strand-separating activity.
Hepatitis C
NS4A regulates the ATPase activity of the NS3 helicase: a novel cofactor role of the non-structural protein NS4A from West Nile virus.
Hepatitis C
Role of the DExH motif of the Japanese encephalitis virus and hepatitis C virus NS3 proteins in the ATPase and RNA helicase activities.
Hepatitis C
The Acidic Domain of Hepatitis C Virus NS4A Contributes to RNA Replication and Virus Particle Assembly.
Hepatitis C, Chronic
The effect of interferon therapy on erythrocyte membrane Na+,K+ ATP activity in patients with chronic hepatitis B and C virus infections.
Hepatolenticular Degeneration
A novel H28Y mutation in LEC rats leads to decreased NAT protein stability in vivo and in vitro.
Hepatolenticular Degeneration
A novel pineal night-specific ATPase encoded by the Wilson disease gene.
Hepatolenticular Degeneration
A pineal regulatory element (PIRE) mediates transactivation by the pineal/retina-specific transcription factor CRX.
Hepatolenticular Degeneration
Analysis of most common mutations R778G, R778L, R778W, I1102T and H1069Q in Indian Wilson disease patients: correlation between genotype/phenotype/copper ATPase activity.
Hepatolenticular Degeneration
Animal models of Wilson disease.
Hepatolenticular Degeneration
Binding of copper(I) by the Wilson disease protein and its copper chaperone.
Hepatolenticular Degeneration
Cellular copper transport and metabolism.
Hepatolenticular Degeneration
Cellular copper transport.
Hepatolenticular Degeneration
Characterization of Fibrinogen as a Key Modulator in Patients with Wilson's Diseases with Functional Proteomic Tools.
Hepatolenticular Degeneration
Chelating polymeric beads as potential therapeutics for Wilson's disease.
Hepatolenticular Degeneration
Copper related toxic effects on cellular protein metabolism in human astrocytes.
Hepatolenticular Degeneration
Copper transport and its defect in Wilson disease: characterization of the copper-binding domain of Wilson disease ATPase.
Hepatolenticular Degeneration
Copper-induced conformational changes in the N-terminal domain of the Wilson disease copper-transporting ATPase.
Hepatolenticular Degeneration
Difference in stability of the N-domain underlies distinct intracellular properties of the E1064A and H1069Q mutants of Cu-transporting ATPase ATP7B.
Hepatolenticular Degeneration
Expression and mutagenesis of ZntA, a zinc-transporting P-type ATPase from Escherichia coli.
Hepatolenticular Degeneration
From and to the Golgi - defining the Wilson disease protein road map.
Hepatolenticular Degeneration
Functional properties of the human copper-transporting ATPase ATP7B (the Wilson's disease protein) and regulation by metallochaperone Atox1.
Hepatolenticular Degeneration
GanDouLing promotes proliferation and differentiation of neural stem cells in the mouse model of Wilson's disease.
Hepatolenticular Degeneration
Genetic and molecular basis for copper toxicity.
Hepatolenticular Degeneration
Hepatocyte-specific localization and copper-dependent trafficking of the Wilson's disease protein in the liver.
Hepatolenticular Degeneration
Identification of mutations in the ATP7B gene in 14 Wilson disease children: Case series.
Hepatolenticular Degeneration
Intracellular trafficking of the human Wilson protein: the role of the six N-terminal metal-binding sites.
Hepatolenticular Degeneration
Late-Onset Wilson's Disease.
Hepatolenticular Degeneration
Metal binding domains 3 and 4 of the Wilson disease protein: solution structure and interaction with the copper(I) chaperone HAH1.
Hepatolenticular Degeneration
Metallochaperone Atox1 transfers copper to the NH2-terminal domain of the Wilson's disease protein and regulates its catalytic activity.
Hepatolenticular Degeneration
Methanobactin reverses acute liver failure in a rat model of Wilson disease.
Hepatolenticular Degeneration
Molecular diagnosis of Wilson disease using prevalent mutations and informative single-nucleotide polymorphism markers.
Hepatolenticular Degeneration
Non-ceruloplasmin bound copper and ATP7B gene variants in Alzheimer's disease.
Hepatolenticular Degeneration
Novel ATPase Cu(2+) transporting beta polypeptide mutations in Chinese families with Wilson's disease.
Hepatolenticular Degeneration
P-type ATPase from the cyanobacterium Synechococcus 7942 related to the human Menkes and Wilson disease gene products.
Hepatolenticular Degeneration
Population screening for Wilson's disease.
Hepatolenticular Degeneration
Potential Role of Brain-Derived Neurotrophic Factor and Dopamine Receptor D2 Gene Variants as Modifiers for the Susceptibility and Clinical Course of Wilson's Disease.
Hepatolenticular Degeneration
Reconstitution of ceruloplasmin by the Cu(I)-glutathione complex. Evidence for a role of Mg2+ and ATP.
Hepatolenticular Degeneration
Reduced FXR Target Gene Expression in Copper-Laden Livers of COMMD1-Deficient Dogs.
Hepatolenticular Degeneration
Role of a Candida albicans P1-type ATPase in resistance to copper and silver ion toxicity.
Hepatolenticular Degeneration
Solution structure of the N-domain of Wilson disease protein: Distinct nucleotide-binding environment and effects of disease mutations.
Hepatolenticular Degeneration
The copper toxicosis gene product Murr1 directly interacts with the Wilson disease protein.
Hepatolenticular Degeneration
The soluble metal-binding domain of the copper transporter ATP7B binds and detoxifies cisplatin.
Hepatolenticular Degeneration
Therapeutic potential of hepatocyte-like-cells converted from stem cells from human exfoliated deciduous teeth in fulminant Wilson's disease.
Hepatolenticular Degeneration
Wilson disease in children.
Hepatolenticular Degeneration
Zinc binding to the NH2-terminal domain of the Wilson disease copper-transporting ATPase: implications for in vivo metal ion-mediated regulation of ATPase activity.
Hepatolenticular Degeneration
[Biological regulation of copper and selective removal of copper: therapy for Wilson disease and its molecular mechanism]
Hepatolenticular Degeneration
[Introduction of DNA microarray in molecular diagnostics of Wilson disease]
Herpes Simplex
1,3-Dihydroxyacridone derivatives as inhibitors of herpes virus replication.
Herpes Simplex
2,3-Dihydroxy-quinoxaline induces ATPase activity of Herpes Simplex Virus thymidine kinase.
Herpes Simplex
A continuous spectrophotometric assay for aspartate transcarbamylase and ATPases.
Herpes Simplex
A DNA helicase induced by herpes simplex virus type 1.
Herpes Simplex
Allosteric crosstalk between peptide-binding, transport, and ATP hydrolysis of the ABC transporter TAP.
Herpes Simplex
Allosteric interaction of a herpes simplex viral thymidine kinase with host DNA polymerase alpha in mouse LP1-1 cells.
Herpes Simplex
Association between the p170 form of human topoisomerase II and progeny viral DNA in cells infected with herpes simplex virus type 1.
Herpes Simplex
Coronavirus interactions with the cellular autophagy machinery.
Herpes Simplex
Effect of novobiocin and other DNA gyrase inhibitors on virus replication and DNA synthesis in herpes simplex virus type 1-infected BHK cells.
Herpes Simplex
Herpes simplex virus 1 activates cdc2 to recruit topoisomerase II alpha for post-DNA synthesis expression of late genes.
Herpes Simplex
Herpes simplex virus helicase-primase: the UL8 protein is not required for DNA-dependent ATPase and DNA helicase activities.
Herpes Simplex
Herpes simplex virus type 1 helicase-primase: DNA binding and consequent protein oligomerization and primase activation.
Herpes Simplex
Identification of novel biomarkers involved in pulmonary arterial hypertension based on multiple-microarray analysis.
Herpes Simplex
Inhibition of topoisomerase II by ICRF-193 prevents efficient replication of herpes simplex virus type 1.
Herpes Simplex
Intracellular trafficking and maturation of herpes simplex virus type 1 gB and virus egress require functional biogenesis of multivesicular bodies.
Herpes Simplex
Nucleotide sequence of a 55 kbp region from the right end of the genome of a pathogenic African swine fever virus isolate (Malawi LIL20/1).
Herpes Simplex
On the complex nature of the antiviral activity of coumermycin A1: its interference with the replication of herpes simplex virus type 1.
Herpes Simplex
Replacement of gly815 in helicase motif V alters the single-stranded DNA-dependent ATPase activity of the herpes simplex virus type 1 helicase-primase.
Herpes Simplex
The conserved helicase motifs of the herpes simplex virus type 1 origin-binding protein UL9 are important for function.
Herpes Simplex
The ESCRT-Related ATPase Vps4 Is Modulated by Interferon during Herpes Simplex Virus 1 Infection.
Herpes Simplex
Topoisomerase II cleavage of herpes simplex virus type 1 DNA in vivo is replication dependent.
Herpes Simplex
Viral-encoded enzymes that target host chromatin functions.
Herpes Zoster
Ex vivo expansion of bovine corneal endothelial cells in xeno-free medium supplemented with platelet releasate.
Herpes Zoster
Neuronal nitric oxide synthase signaling in the heart is regulated by the sarcolemmal calcium pump 4b.
Herpes Zoster
Novel genetic determinants of adrenal aldosterone regulation.
Herpes Zoster
Nuclear transfer technique affects mRNA abundance, developmental competence, and cell fate of the reconstituted sheep oocytes.
Herpes Zoster
Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension.
Histiocytic Sarcoma
Histiocytic malignancies. Morphologic, immunologic, and enzymatic heterogeneity.
Histiocytoma, Malignant Fibrous
Enzyme histochemical study on bone tumors.
Histiocytosis
Translocation (11;11)(p13- p15;q23) in a child with therapy-related acute myeloid leukemia following chemotherapy with DNA-topoisomerase II inhibitors for Langerhans cell histiocytosis.
Histiocytosis, Langerhans-Cell
Translocation (11;11)(p13- p15;q23) in a child with therapy-related acute myeloid leukemia following chemotherapy with DNA-topoisomerase II inhibitors for Langerhans cell histiocytosis.
Hodgkin Disease
Breast cancer after mantle irradiation for Hodgkin's disease: correlation of clinical, pathologic, and molecular features including loss of heterozygosity at BRCA1 and BRCA2.
Hodgkin Disease
Correspondence re: M. Provencio, et al. the topoisomerase IIa expression correlates with survival in patients with advanced Hodgkin's lymphoma. Clin. Cancer Res., 9: 1406-1411, 2003.
Hodgkin Disease
Genetic abnormalities in leukemia secondary to treatment in patients with Hodgkin's disease.
Hodgkin Disease
Immunohistochemical staining for DNA topoisomerase IIa in Hodgkin's disease.
Hodgkin Disease
Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: evidence for genomic instability.
Hodgkin Disease
The Risk of Therapy-Related Myelodysplasia/Acute Myeloid Leukemia in Hodgkin Lymphoma has Substantially Decreased in the ABVD Era Abolishing Mechlorethamine and Procarbazine and Limiting Volumes and Doses of Radiotherapy.
Hodgkin Disease
The topoisomerase IIalpha expression correlates with survival in patients with advanced Hodgkin's lymphoma.
Hodgkin Disease
Topoisomerase II{alpha} Expression as an Independent Prognostic Factor in Hodgkin's Lymphoma.
Hordeolum
Cloning and functional characterization of the styE gene, involved in styrene transport in Pseudomonas putida CA-3.
Huntington Disease
Biochemical markers for Huntington's chorea.
Huntington Disease
Endogenous sodium-potassium ATPase inhibition related biochemical cascade in trisomy 21 and Huntington's disease: neural regulation of genomic function.
Huntington Disease
Investigation of tRNA(Leu/Lys) and ATPase 6 genes mutations in Huntington's disease.
Hydrocephalus
[Effects of salvianolic acid B on cerebral energy charge and activity of ATPase in mice with cerebral ischemia]
Hyper-IgM Immunodeficiency Syndrome
The molecular basis of X-linked agammaglobulinemia, hyper-IgM syndrome, and severe combined immunodeficiency in humans.
Hyperaldosteronism
Aldosterone increases Na(+) - K(+) - ATPase activity in skeletal muscle of patients with Conn's syndrome.
Hyperaldosteronism
Clinical and Steroidogenic Characteristics of Aldosterone-Producing Adenomas With ATPase or CACNA1D Gene Mutations.
Hyperaldosteronism
Colonic H(+)-K(+)-ATPase in K(+) conservation and electrogenic Na(+) absorption during Na(+) restriction.
Hyperaldosteronism
Effect of metabolic acidosis and alkalosis on NEM-sensitive ATPase in rat nephron segments.
Hyperaldosteronism
Na-K-ATPase in erythrocyte ghosts is not a marker for primary hypertension.
Hyperaldosteronism
Secondary hyperaldosteronism stimulates acidification in rat distal colon.
Hyperaldosteronism
Somatic mutations of the ATP1A1 gene and aldosterone-producing adenomas.
Hyperalgesia
N-acetylcysteine Inhibits Hyperglycemia-induced Oxidative Stress and Apoptosis Markers in Diabetic Neuropathy.
Hypercholesterolemia
In vivo influence of extract from Aronia melanocarpa on the erythrocyte membranes in patients with hypercholesterolemia.
Hypercholesterolemia
[Calcium transport and ATPase activity of mitochondria and sarcoplasmic reticulum fragments of rabbit heart and muscle in hypercholesteremia]
Hyperglycemia
Blockade of early and late retinal biochemical alterations associated with diabetes development by the selective bradykinin B(1) receptor antagonist R-954.
Hyperglycemia
Effect of hyperglycemia duration on rabbit corneal thickness and endothelial ATPase activity.
Hyperglycemia
Effect of maternal hyperglycemia on NaK ATPase activity in fetal rat kidney.
Hyperglycemia
Endothelium-dependent inhibition of Na(+)-K+ ATPase activity in rabbit aorta by hyperglycemia. Possible role of endothelium-derived nitric oxide.
Hyperglycemia
Glucocorticoids may trigger attacks in several types of periodic paralysis.
Hyperglycemia
Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction.
Hyperglycemia
Oxygen consumption and ATPase activity in the corneal epithelium of rabbits with alloxan induced hyperglycemia.
Hyperglycemia
The effect of streptozotocin-induced diabetes in rats on cardiac contractile proteins.
Hyperglycemia
The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet ?-Cell Function.
Hyperhomocysteinemia
Mild Hyperhomocysteinemia Causes Anxiety-like Behavior and Brain Hyperactivity in Rodents: Are ATPase and Excitotoxicity by NMDA Receptor Overstimulation Involved in this Effect?
Hyperhomocysteinemia
Response of secretory pathways Ca(2+) ATPase gene expression to hyperhomocysteinemia and/or ischemic preconditioning in rat cerebral cortex and hippocampus.
Hyperhomocysteinemia
Severe Hyperhomocysteinemia Decreases Respiratory Enzyme and Na(+)-K(+) ATPase Activities, and Leads to Mitochondrial Alterations in Rat Amygdala.
Hyperinsulinism
Mechanism of thyrotoxic periodic paralysis.
Hyperkalemia
Activation of K+ channel and inhibition of Na(+)-K+ ATPase of human erythrocytes by cyclosporine: possible role in hyperpotassemia in kidney transplant recipients.
Hyperkalemia
Effects of thyroxine on hyperkalemia and renal cortical Na+, K+ - ATPase activity induced by cyclosporin A.
Hyperkalemia
Fructose-1,6-diphosphate in the treatment of oleander toxicity in dogs.
Hyperkalemia
Oleander tea: herbal draught of death.
Hyperkalemia
Reduction of erythrocyte (Na(+)-K+) ATPase activities in non-insulin-dependent diabetic patients with hyperkalemia.
Hyperkinesis
Twisting mice move the dystonia field forward.
Hyperlipidemias
Damage to the structure of erythrocyte plasma membranes in patients with type-2 hypercholesterolemia.
Hyperlipidemias
Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction.
Hyperlipoproteinemia Type I
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Hyperlipoproteinemias
[Lipid composition and ATPase activity of the myocardial sarcoplasmic reticulum in experimental hyperlipoproteinemia]
Hyperlipoproteinemias
[The effect of the alimentary factor on erythrocyte ATPase activity in ischemic heart disease patients]
Hyperparathyroidism, Secondary
Cardiovascular complications in end-stage renal disease and hemodialysis patients.
Hyperparathyroidism, Secondary
Reduced activity of Na(+)-K+ ATPase of pancreatic islets in chronic renal failure: role of secondary hyperparathyroidism.
Hypersensitivity
A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development.
Hypersensitivity
A circulating inhibitor of the platelet Na+,K+ adenosine triphosphatase (ATPase) enzyme in allergy.
Hypersensitivity
A mechanism for P-glycoprotein-mediated apoptosis as revealed by verapamil hypersensitivity.
Hypersensitivity
A mutation in yeast topoisomerase II that confers hypersensitivity to multiple classes of topoisomerase II poisons.
Hypersensitivity
A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine.
Hypersensitivity
Action of etoposide (VP-16-123) on human cells: no evidence for topoisomerase II involvement in excision repair of u.v.-induced DNA damage, nor for mitochondrial hypersensitivity in ataxia telangiectasia.
Hypersensitivity
ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair.
Hypersensitivity
Amsacrine and etoposide hypersensitivity of yeast cells overexpressing DNA topoisomerase II.
Hypersensitivity
Ataxia telangiectasia mutated-dependent regulation of topoisomerase II alpha expression and sensitivity to topoisomerase II inhibitor.
Hypersensitivity
Cellular consequences of overproduction of DNA topoisomerase II in an ataxia-telangiectasia cell line.
Hypersensitivity
Chlorhexidine hypersensitivity of ciprofloxacin-resistant variants of Pseudomonas aeruginosa PAO.
Hypersensitivity
Constitutive Stringent Response Restores Viability of Bacillus subtilis Lacking Structural Maintenance of Chromosome Protein.
Hypersensitivity
Contribution of the ATP binding site of ParE to susceptibility to novobiocin and quinolones in Streptococcus pneumoniae.
Hypersensitivity
Cross-sensitivity to topoisomerase II inhibitors in cytotoxic drug-hypersensitive Chinese hamster ovary cell lines.
Hypersensitivity
Cyclic AMP-dependent protein kinase type I is involved in hypersensitivity of human breast cells to topoisomerase II inhibitors.
Hypersensitivity
Density of Langerhans' cells in ATPase stained epidermal sheet preparations from stasis dermatitis skin of the lower leg.
Hypersensitivity
Development of anthracenyl-amino acid conjugates as topoisomerase I and II inhibitors that circumvent drug resistance.
Hypersensitivity
DNA topoisomerase II as a target of antineoplastic drug therapy.
Hypersensitivity
DNase I hypersensitivity is independent of endogenous topoisomerase II activity during chicken erythrocyte differentiation.
Hypersensitivity
Exonuclease VII repairs quinolone-induced damage by resolving DNA gyrase cleavage complexes.
Hypersensitivity
Functional assessment of Nramp-like metal transporters and manganese in Caenorhabditis elegans.
Hypersensitivity
Genetic evidence for involvement of two distinct nonhomologous end-joining pathways in repair of topoisomerase II-mediated DNA damage.
Hypersensitivity
Genome-wide prediction of topoisomerase II? binding by architectural factors and chromatin accessibility.
Hypersensitivity
gyrB-225, a mutation of DNA gyrase that compensates for topoisomerase I deficiency: investigation of its low activity and quinolone hypersensitivity.
Hypersensitivity
Hypersensitivity of Ku-deficient cells toward the DNA topoisomerase II inhibitor ICRF-193 suggests a novel role for Ku antigen during the G2 and M phases of the cell cycle.
Hypersensitivity
In vitro modulation of platelet sodium, potassium adenosine triphosphatase enzyme activity by antiallergy drugs.
Hypersensitivity
Increase in calcium responsiveness of cardiac myofilament activation in ovariectomized rats.
Hypersensitivity
Isolation and characterisation of a mutation in the PMR1 gene encoding a Golgi membrane ATPase, which causes hypersensitivity to over-expression of Clb3 in Saccharomyces cerevisiae.
Hypersensitivity
Isolation and partial characterisation of a mammalian cell mutant hypersensitive to topoisomerase II inhibitors and X-rays.
Hypersensitivity
Large-scale analysis of genes that alter sensitivity to the anticancer drug tirapazamine in Saccharomyces cerevisiae.
Hypersensitivity
Mammalian Fbh1 is important to restore normal mitotic progression following decatenation stress.
Hypersensitivity
MCPH1 Lack of Function Enhances Mitotic Cell Sensitivity Caused by Catalytic Inhibitors of Topo II.
Hypersensitivity
Modification of survival by DNA repair modifiers: a probable explanation for the phenomenon of increased radioresistance.
Hypersensitivity
Mutation at the "exit gate" of the salmonella gyrase a subunit suppresses a defect in the gyrase B subunit.
Hypersensitivity
Mutation E522K in human DNA topoisomerase IIbeta confers resistance to methyl N-(4'-(9-acridinylamino)-phenyl)carbamate hydrochloride and methyl N-(4'-(9-acridinylamino)-3-methoxy-phenyl) methane sulfonamide but hypersensitivity to etoposide.
Hypersensitivity
Mutation of a conserved serine residue in a quinolone-resistant type II topoisomerase alters the enzyme-DNA and drug interactions.
Hypersensitivity
Mutation of alanine 24 to serine in subunit c of the Escherichia coli F1F0-ATP synthase reduces reactivity of aspartyl 61 with dicyclohexylcarbodiimide.
Hypersensitivity
Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate.
Hypersensitivity
Overexpression of the RI alpha subunit of protein kinase A confers hypersensitivity to topoisomerase II inhibitors and 8-chloro-cyclic adenosine 3'5'-monophosphate in Chinese hamster ovary cells.
Hypersensitivity
Partial proteolysis as a probe of the conformation of the gamma subunit in activated soluble and membrane-bound chloroplast coupling factor 1.
Hypersensitivity
PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis.
Hypersensitivity
Sperm decondensation during fertilisation in the mouse: presence of DNase I hypersensitive sites in situ and a putative role for topoisomerase II.
Hypersensitivity
Synthesis and biological activity of thiazolylindolequinones, analogues of the natural product BE 10988.
Hypersensitivity
The histone deacetylase inhibitor sodium butyrate induces DNA topoisomerase II alpha expression and confers hypersensitivity to etoposide in human leukemic cell lines.
Hypersensitivity
The isolation and genetic analysis of V79-derived etoposide sensitive Chinese hamster cell mutants: two new complementation groups of etoposide sensitive mutants.
Hypersensitivity
The SWI2/SNF2 chromatin remodeling ATPase BRAHMA represses abscisic acid responses in the absence of the stress stimulus in Arabidopsis.
Hypersensitivity
Time- and Cost-Efficient Identification of T-DNA Insertion Sites through Targeted Genomic Sequencing.
Hypersensitivity
Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders.
Hypersensitivity
Virtual prototyping study shows increased ATPase activity of Hsp90 to be the key determinant of cancer phenotype.
Hypertension
(Na+ -K+)ATPase activity in erythrocyte membranes of spontaneously, one kidney-one wrapped, and deoxycorticosterone acetate--NaCl hypertensive rats.
Hypertension
A study of erythrocyte membrane cation transport adenosine triphosphatases in pregnancy-induced hypertension and of in vivo effects of diuretic treatment.
Hypertension
Abnormal cation exchange in insulin-resistant patients with essential hypertension.
Hypertension
Age dependent changes in myosin ATPase activity in the myocardium of spontaneously hypertensive rats.
Hypertension
Altered calcium regulation in the cardiac plasma membrane in experimental renal hypertension.
Hypertension
Altered expression of troponin T isoforms in mild left ventricular hypertrophy in the rabbit.
Hypertension
Altered responses of aortic smooth muscle from Sprague-Dawley rats with salt-induced hypertension.
Hypertension
Catecholamine-stimulated potassium transport in erythrocytes from normal and obese subjects.
Hypertension
Changes in rat ventricular isomyosins with regression of cardiac hypertrophy.
Hypertension
Circulating bufodienolide and cardenolide sodium pump inhibitors in preeclampsia.
Hypertension
Decreased calcium pump adenosine triphosphatase in red blood cells of hypertensive subjects.
Hypertension
Decreased Na+K+ATPase activity in the aortic endothelium and smooth muscle of the spontaneously hypertensive rats.
Hypertension
Disorders of erythrocyte structure and function in hypertensive patients.
Hypertension
Effect of ageing and hypertension on endothelial modulation of ouabain-induced contraction and sodium pump activity in the rat aorta.
Hypertension
Effect of aging and hypertension on myosin biochemistry and gene expression in the rat heart.
Hypertension
Effects of chronic dobutamine administration on hearts of normal and hypertensive rats.
Hypertension
Effects of sarcoplasmic reticulum calcium pump inhibitors on vascular smooth muscle.
Hypertension
Endogenous digitalis-like factors: an overview of the history.
Hypertension
Enhancement of intrarenal plasma membrane calcium pump isoform 1 expression in chronic angiotensin II-infused mice.
Hypertension
Erythrocyte sodium concentration and 86Rb uptake in weanling Dahl rats.
Hypertension
Hypertension and (Na-K) ATPase activity in brain.
Hypertension
Insufficient fumarase contributes to hypertension by an imbalance of redox metabolism in Dahl salt-sensitive rats.
Hypertension
Insulin Increases D(5) Dopamine Receptor Expression and Function in Renal Proximal Tubule Cells From Wistar-Kyoto Rats.
Hypertension
Isolation of genomic clones coding for the heavy chains of two human cardiac myosins.
Hypertension
Lead-induced hypertension: role of oxidative stress.
Hypertension
Marinobufagenin impairs first trimester cytotrophoblast differentiation.
Hypertension
Measurements on the activity of the plasma membrane Ca pump ATPase in human hypertension.
Hypertension
Na-K ATPase activity of erythrocyte membrane correlated with urinary Na/K ratio in normotensive adolescents with a family history of hypertension.
Hypertension
Ouabain stimulates Na-K ATPase through sodium hydrogen exchanger-1 (NHE-1) dependent mechanism in human kidney proximal tubule cells.
Hypertension
Palytoxin Poisoning After Dermal Contact with Zoanthid Coral.
Hypertension
Pathogenesis of lead-induced hypertension: role of oxidative stress.
Hypertension
Periventricular forebrain mechanisms for blood pressure regulation.
Hypertension
Plasma sodium-potassium ATPase inhibition activity in low- and normal-renin hypertension.
Hypertension
Progression and regression of cardiac hypertrophy in hypertensive rats: biochemical and molecular changes in ventricular myosin.
Hypertension
Proliferating cell nuclear antigen involved in the repair process of ouabain-induced brain damage independent of hypertension in rats.
Hypertension
PST-2238 Sigma-Tau.
Hypertension
Reduced sodium-potassium dependent ATPase and its possible role in the development of hypertension in spontaneously hypertensive rats.
Hypertension
Regulation of Na+/K+-ATPase by Estradiol and IGF-1 in Cardio-Metabolic Diseases.
Hypertension
Relationship between neuropathy, hypertension and red blood cell Na/K ATPase in patients with insulin-dependent diabetes mellitus.
Hypertension
Resibufogenin Prevents the Manifestations of Preeclampsia in an Animal Model of the Syndrome.
Hypertension
Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension.
Hypertension
Salt-induced hypertension in rats alters the response of isolated aortic rings to cromakalim.
Hypertension
Significant difference in the effect of acute saline loading on plasma Na-K ATPase inhibitor and blood pressure between children and adults with essential hypertension.
Hypertension
SIK1 localizes with nephrin in glomerular podocytes and its polymorphism predicts kidney injury.
Hypertension
Sodium-potassium ATPase in deoxycorticosterone-salt hypertension: opposing effects of sodium load and mineralocorticoids.
Hypertension
Sodium-potassium-dependent ATPase activity in erythrocyte ghosts of patients with primary and secondary hypertension.
Hypertension
Systemic Hypertension Effects on the Ciliary Body and Iris. An Immunofluorescence Study with Aquaporin 1, Aquaporin 4, and Na?, K? ATPase in Hypertensive Rats.
Hypertension
[Activity of the systems of transmembrane transport of Na+ (Na+-K+ ATPase, Na+-K+-Cl cotransport, Na+-Li+ countertransport and passive Na+ diffusion) in essential arterial hypertension]
Hypertension
[Activity of transporting ATPase and functional properties of blood cells in patients with hypertension]
Hypertension
[Alkaline phosphatase and ATPase activity in the walls of the cerebral vessels in hypertension and arteriosclerosis with disorders of the cerebral circulation]
Hypertension
[Cellular bases of hypertension in pregnancy. V. Study of sodium, potassium ATPase in erythrocyte ghosts]
Hypertension
[Cytochemical demonstration of an endogenous inhibitor of Na-K ATPase and its relationship to familial arterial hypertension]
Hypertension
[Effect of linoleic acid in the diet on arterial pressure, ATPase activity and cyclic nucleotide level in the heart of rats with spontaneous hypertension]
Hypertension
[Effect of vasodilator preparations on the ATPase activity of the erythrocyte membranes of rabbits with experimental vascular pathology]
Hypertension
[Evaluation of maximal Na K ATPase activity in the erythrocytes of patients with various types of arterial hypertension using the Na-23-NMR method]
Hypertension
[Genetic hypertension in the SHR rat and circulating digitalis compounds]
Hypertension
[Mg2+ activity and kidney and liver Na+ - K+ and ATPase in rats with spontaneous hypertension (proceedings)]
Hypertension
[Na K ATPase activity and pulmonary hemodynamics in the development of arterial hypertension]
Hypertension
[Presence and regulation of plasma with natriuretic and Na-K ATPase inhibitory properties in normotensive subjects]
Hypertension
[Role of membrane-bound calcium in the changes of ion permeability and Na+, 5+ and ATPase activity of the erythrocytes in hypertension]
Hypertension
[Studies on the interaction of genetic and environmental factors associated with blood pressure in female adolescents--family score for hypertension and erythrocyte membrane Na-K ATPase activity]
Hypertension
[The Ca pump and Ca ATPase in the erythrocytes of patients with hypertension: disorders detected in cytoskeletal membranes and in solubilized Ca ATPase]
Hypertension
[Variations in ATPase activities of erythrocytic membrane and endocytic ionic levels in cases with pregnancy induced hypertension]
Hypertension, Malignant
Alterations in intracellular cations and cell membrane ATPase activity in patients with malignant hypertension.
Hypertension, Pregnancy-Induced
A study of erythrocyte membrane cation transport adenosine triphosphatases in pregnancy-induced hypertension and of in vivo effects of diuretic treatment.
Hypertension, Pregnancy-Induced
[Variations in ATPase activities of erythrocytic membrane and endocytic ionic levels in cases with pregnancy induced hypertension]
Hypertension, Renal
Na-K-ATPase in erythrocyte ghosts is not a marker for primary hypertension.
Hypertension, Renovascular
Alterations in gene expression in the rat heart after chronic pathological and physiological loads.
Hypertension, Renovascular
Renovascular hypertension using a modified two-kidney, one-clip approach in mice is not dependent on the {alpha}1 or {alpha}2 Na,K-ATPase ouabain-binding site.
Hyperthyroidism
Alteration in activities of Na,K, ATPase, sugar transport, and insulin receptors in erythrocytes from hyperthyroid patients.
Hyperthyroidism
Alteration in intracellular sodium concentration and ouabain-sensitive ATPase in erythrocytes from hyperthyroid patients.
Hyperthyroidism
Calcium transport ATPase of cardiac sarcoplasmic reticulum in experimental hyperthyroidism.
Hyperthyroidism
Cation transport in intact erythrocytes of hyperthyroid patients: role of the NaK-ATPase pump.
Hyperthyroidism
Changes in cardiac myofibrillar ATPase activity during development of hyperthyroidism in the rabbit.
Hyperthyroidism
Comparative studies of atrial and ventricular myosin from normal, thyrotoxic, and thyroidectomized rabbits.
Hyperthyroidism
Coordinate downregulation of CaM kinase II and phospholamban accompanies contractile phenotype transition in the hyperthyroid rabbit soleus.
Hyperthyroidism
Effect of thyroid status on ouabain binding to the human lymphocyte.
Hyperthyroidism
Effects of oxidative stress on the erythrocyte Na+,K+ ATPase activity in female hyperthyroid patients.
Hyperthyroidism
Effects of thyroid hormones on contractility and cation transport in skeletal muscle.
Hyperthyroidism
Erythrocyte sodium/potassium adenosine triphosphatase in thyroid disease and nonthyroidal illness.
Hyperthyroidism
Evaluation of peripheral metabolic status by determination of Na-K ATPase pump activity in circulating erythrocytes in patients with thyroid diseases and nonthyroidal illnesses.
Hyperthyroidism
Hyperthyroidism increases the uncoupled ATPase activity and heat production by the sarcoplasmic reticulum Ca2+-ATPase.
Hyperthyroidism
Increased calcium leak associated with reduced calsequestrin expression in hyperthyroid cardiomyocytes.
Hyperthyroidism
Influence of the thyroid state on myocardial myosin in the adult pig heart.
Hyperthyroidism
Maximum speed of shortening and ATPase activity in atrial and ventricular myocardia of hyperthyroid rats.
Hyperthyroidism
Mechanical properties and ATPase activity in glycerinated cardiac muscle of hyperthyroid rabbit.
Hyperthyroidism
Na+, K+ ATPase activity in red cells predicts the recurrence of hyperthyroidism in patients with Graves' disease.
Hyperthyroidism
Na-K-dependent ATPase in red cells and thyroid status.
Hyperthyroidism
Peripheral effects of thyroid hormones: alteration of intracellular Na-concentration, ouabain-sensitive Na-transport, and Na-Li countertransport in human red blood cells.
Hyperthyroidism
Reconstitution of heavy chain and light chain 1 in cardiac subfragment-1 from hyperthyroid and euthyroid rabbit hearts.
Hyperthyroidism
Regulation of cardiac sarcolemmal Ca2+ channels and Ca2+ transporters by thyroid hormone.
Hyperthyroidism
Steroids and Thyrotoxicosis Precipitate Periodic Paralysis.
Hyperthyroidism
The effect of hyperthyroidism on capillarity and oxidative capacity in rat soleus and gastrocnemius muscles.
Hyperthyroidism
The effect of thyroid hormone on bile salt-independent bile flow and Na+, K+ -ATPase activity in liver plasma membranes enriched in bile canaliculi.
Hyperthyroidism
The effects of thyroid status on digoxin distribution in the rat.
Hyperthyroidism
Thyroid hormone regulation of MHC isoform composition and myofibrillar ATPase activity in rat skeletal muscles.
Hyperthyroidism
Thyrotoxic Periodic Paralysis with Sensory Deficits in Young African American Male: A Case Report and Literature Review.
Hyperthyroidism
Thyroxine-induced cardiomegaly: assessment of nucleic acid, protein content and myosin ATPase of rat heart.
Hyperthyroidism
Ventral prostatic phosphomonoesterases and adenosine triphosphatases in hypo- and hyperthyroid albino rats.
Hyperthyroidism
Ventricular and aortic myosin in hypothyroid and hyperthyroid broad breasted white turkeys.
Hyperthyroidism
[Cardiac myosins and myocardial contraction]
Hyperthyroidism
[Clinical studies on assay for Na-K ATPase in human blood cells. I. Erythrocyte Na-K ATPase assay in patients with thyroid dysfunction and in those with chronic renal failure]
Hypertrophy, Left Ventricular
Effects of crocetin on the matrix metalloproteinases in cardiac hypertrophy induced by norepinephrine in rats.
Hypertrophy, Left Ventricular
Myocardial phenotypic changes in Na+, K+ ATPase in left ventricular hypertrophy: pharmacological consequences.
Hypertrophy, Left Ventricular
Relationship between the myofibrillar ATPase activity of human biopsy material and hemodynamic parameters.
Hypoalphalipoproteinemias
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Hypocalcemia
Effects of copper on an omnivorous (Astyanax altiparanae) and a carnivorous fish (Hoplias malabaricus): A comparative approach.
Hypoglycemia
Hypoglycemia enhances ionotropic but reduces metabotropic glutamate responses in substantia nigra dopaminergic neurons.
Hypoglycemia
The effect of severe hypoglycemia upon cerebrospinal fluid formation, ventricular iodide clearance, and brain electrolytes in rabbits.
Hypoglycemia
[ATPase activity of rat brain microsomal and synaptosomal fractions in insulin hypoglycemia and its treatment with glucose]
Hypoglycemia
[The effect of hypoglycemia on Na+-K+ and Mg2+ stimulated ATPase activity in the brain of rats of various ages]
Hypokalemia
Clinical review: Thyrotoxic periodic paralysis: a diagnostic challenge.
Hypokalemia
Diuretics, digitalis and arrhythmias.
Hypokalemia
Glucocorticoids may trigger attacks in several types of periodic paralysis.
Hypokalemia
Gossypol and Na+, K+ ATPase from human erythrocytes.
Hypokalemia
Thyrotoxic Periodic Paralysis: An Incidental Diagnosis!
Hypokalemia
Thyrotoxic Periodic Paralysis: Clinical Challenges.
Hypokinesia
[Effect of hypokinesia on the contractile function of the myocardium]
Hyponatremia
Effects of copper on an omnivorous (Astyanax altiparanae) and a carnivorous fish (Hoplias malabaricus): A comparative approach.
Hypophosphatemia, Familial
Renal sodium transport in vitamin D resistant hypophosphatemic rickets.
Hypotension
Myocardial ischaemic/reperfusion injury in the anaesthetized rabbit: comparative effects of halothane and isoflurane.
Hypothyroidism
Aldosterone, sodium depletion and hypothyroidism on the ATPase activity of rat colonic epithelium.
Hypothyroidism
Alterations of Ca 2 uptake and Ca 2+ activated ATPase of cardiac sarcoplasmic reticulum in hyper- and hypothyroidism.
Hypothyroidism
Beta-adrenergic receptors, adenylate cyclase activation, and myofibril enzyme activity in hypothyroid rats.
Hypothyroidism
Cardiac myofibrillar creatine kinase is not influenced by hypothyroidism.
Hypothyroidism
Cyclic AMP regulation of myosin isozymes in mammalian cardiac muscle.
Hypothyroidism
Effects of hyper- and hypothyroidism on carbonic anhydrase, Mg2(+)-dependent ATPase and Mg2(+)-dependent, HCO3(-)-stimulated ATPase activities of rat duodenal mucosa and kidney cortex.
Hypothyroidism
Evaluation of peripheral metabolic status by determination of Na-K ATPase pump activity in circulating erythrocytes in patients with thyroid diseases and nonthyroidal illnesses.
Hypothyroidism
Evidence for a direct action of thyroid hormone in specifying muscle properties.
Hypothyroidism
Hypothyroidism Associated with ATP8B1 Deficiency.
Hypothyroidism
Hypothyroidism prevents postnatal changes in rat liver mitochondrial populations defined by rhodamine-123 staining.
Hypothyroidism
Influence of the thyroid state on myocardial myosin in the adult pig heart.
Hypothyroidism
Na-K-dependent ATPase in red cells and thyroid status.
Hypothyroidism
Postnatal mitochondrial differentiation in rat liver. Regulation by thyroid hormones of the beta-subunit of the mitochondrial F1-ATPase complex.
Hypothyroidism
Ventricular and aortic myosin in hypothyroid and hyperthyroid broad breasted white turkeys.
Hypothyroidism
[Clinical studies on assay for Na-K ATPase in human blood cells. I. Erythrocyte Na-K ATPase assay in patients with thyroid dysfunction and in those with chronic renal failure]
Hypothyroidism
[Energy utility of failing heart]
Hypothyroidism
[Influence of congenital hypothyroidism on the developing rat brain and improvement after thyroid replacement therapy]
Hypoventilation
Endogenous marinobufagenin-like immunoreactive factor and Na+, K+ ATPase inhibition during voluntary hypoventilation.
Hypoxia, Brain
[Mechanisms of the adaptive and trophic effects of the sympathetic nervous system on brain vessels and tissue]
Idiopathic Pulmonary Fibrosis
Anti-topoisomerase II alpha autoantibodies in systemic sclerosis-association with pulmonary hypertension and HLA-B35.
Idiopathic Pulmonary Fibrosis
Antibodies to topoisomerase II in idiopathic pulmonary fibrosis.
Idiopathic Pulmonary Fibrosis
Autoantibodies to DNA topoisomerase II in cryptogenic fibrosing alveolitis and connective tissue disease.
Idiopathic Pulmonary Fibrosis
Hypothalamic digoxin, hemispheric chemical dominance, and interstitial lung disease.
Idiopathic Pulmonary Fibrosis
Mapping of topoisomerase II alpha epitopes recognized by autoantibodies in idiopathic pulmonary fibrosis.
Immune System Diseases
Comparative transcriptome analysis of Eriocheir japonica sinensis response to environmental salinity.
Infarction, Middle Cerebral Artery
Edema, cation content, and ATPase activity after middle cerebral artery occlusion in rats.
Infarction, Middle Cerebral Artery
The effects of the pre-treatment of intravenous nimodipine on Na(+)-K+/Mg+2 ATPase, Ca+2/Mg+2 ATPase, lipid peroxidation and early ultrastructural findings following middle cerebral artery occlusion in the rat.
Infarction, Middle Cerebral Artery
The effects of the pretreatment of intravenous high dose methylprednisolone on Na(+)-K(+)/Mg(+2) ATPase and lipid peroxidation and early ultrastructural findings following middle cerebral artery occlusion in the rat.
Infections
A Cost Analysis of Gyrase A Testing and Targeted Ciprofloxacin Therapy Versus Recommended 2-Drug Therapy for Neisseria gonorrhoeae Infection.
Infections
A DNA-unwinding enzyme induced in bacteriophage-T4-infected Escherichia coli cells.
Infections
A non-canonical role of the p97 complex in RIG-I antiviral signaling.
Infections
A novel inhibitor of gyrase B is a potent drug candidate for treatment of tuberculosis and nontuberculosis mycobacterial infections.
Infections
A phage protein-derived antipathogenic peptide that targets type IV pilus assembly.
Infections
A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa.
Infections
Action of cation transfer ATPase inhibitors on efficiency of infection with poliovirus.
Infections
Additive effect of adenovirus-mediated E2F-1 gene transfer and topoisomerase II inhibitors on apoptosis in human osteosarcoma cells.
Infections
Adenovirus-mediated human topoisomerase IIalpha gene transfer increases the sensitivity of etoposide-resistant human breast cancer cells.
Infections
Aedes aegypti SNAP and a calcium transporter ATPase influence dengue virus dissemination.
Infections
African swine fever virus ORF P1192R codes for a functional type II DNA topoisomerase.
Infections
Alteration in expression of the rat mitochondrial ATPase 6 gene during Pneumocystis carinii infection.
Infections
Alteration of DNA topoisomerase II activity during infection of H9 cells by human immunodeficiency virus type 1 in vitro: a target for potential therapeutic agents.
Infections
Alterations in quantitative distribution of Na,K-ATPase activity along crypt-villus axis in animal model of malabsorption characterized by hyperproliferative crypt cytokinetics.
Infections
Amifloxacin activity against well-defined gentamicin-resistant, gram-negative bacteria.
Infections
Antagonism of the Sodium-Potassium ATPase Impairs Chikungunya Virus Infection.
Infections
Antiviral activity of topoisomerase II catalytic inhibitors against Epstein-Barr virus.
Infections
Association of topoisomerases I and II with the chromatin in SV40-infected monkey cells.
Infections
Associations between epidermal growth factor receptor and topoisomerase II-alpha gene copy number variations, human papillomavirus positivity, and cytologic analysis in cervical cell lesions.
Infections
Biological cost of single and multiple norfloxacin resistance mutations in Escherichia coli implicated in urinary tract infections.
Infections
Bluetongue virus entry into cells.
Infections
Burkholderia pseudomallei type III secretion system cluster 3 ATPase BsaS: a chemotherapeutic target for small molecule ATPase inhibitors.
Infections
Changes in mammalian copper homeostasis during microbial infection.
Infections
Characterization of simian virus 40 large T antigen by using different monoclonal antibodies: T-p53 complexes are preferentially ATPase active and adenylylated.
Infections
Characterization of the oligomycin-sensitivity properties of the F1F0-ATPase in mitochondria from rats infected with the liver fluke Fasciola hepatica.
Infections
Ciprofloxacin May be Efficacious in Treating Wild-Type Gyrase A Genotype Neisseria gonorrhoeae Infections.
Infections
Clinical utility of DNA gyrase inhibitors.
Infections
Cloning, functional analysis and post-transcriptional regulation of a type II DNA topoisomerase from Leishmania infantum. A new potential target for anti-parasite drugs.
Infections
Co-Incidence of Type II Topoisomerase Mutations and Efflux Expression in High Fluoroquinolone Resistant Enterococcus faecalis Isolated from Urinary Tract Infections.
Infections
Comparison of minimum inhibitory concentration results for gepotidacin obtained using agar dilution and broth microdilution methods.
Infections
Concanamycin A: a powerful inhibitor of enveloped animal-virus entry into cells.
Infections
Contribution of epidemiological studies to gastritis immunology.
Infections
Design and development of some thiazole-based flavanoids as novel antibacterial against pathogens causing surgical site infection for possible benefit in bone trauma via inhibition of DNA gyrase.
Infections
Detection of highly ciprofloxacin resistance acinetobacter baumannii isolated from patients with burn wound infections in presence and absence of efflux pump inhibitor.
Infections
Development of escherichia coli virus T1. ATP-mediated discrimination of gene expression.
Infections
Differential in vitro anti-HIV activity of natural lignans.
Infections
Direct detection of five common dermatophyte species in clinical samples using a rapid and sensitive 24-h PCR-ELISA technique open to protocol transfer.
Infections
Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV.
Infections
Discovery of Furanoquinone Derivatives as a Novel Class of DNA Polymerase and Gyrase Inhibitors for MRSA Eradication in Cutaneous Infection.
Infections
Distribution of ATPase activity at the host-pathogen interfaces of rust infections.
Infections
Diverse ATPase Proteins in Mobilomes Constitute a Large Potential Sink for Prokaryotic Host ATP.
Infections
DNA gyrase requirements distinguish the alternate pathways of Mu transposition.
Infections
Effect of praziquantel treatment on brain and kidney ATPase activities in healthy and schistosoma mansoni-infected mice.
Infections
Effects of glycyrrhizin on the growth cycle and ATPase activity of PRRSV-2-infected MARC-145 cells.
Infections
Effects of the epipodophyllotoxin VP-16-213 on herpes simplex virus type 2 replication.
Infections
Elemental changes during sexual maturation inSchistosoma mansoni.
Infections
Enhanced etoposide sensitivity following adenovirus-mediated human topoisomerase IIalpha gene transfer is independent of topoisomerase IIbeta.
Infections
Enteropathogenic Escherichia coli inhibits butyrate uptake in Caco-2 cells by altering the apical membrane MCT1 level.
Infections
EPEC effector EspF promotes Crumbs3 endocytosis and disrupts epithelial cell polarity.
Infections
Epidemiological study of Candida species in cutaneous candidiasis based on PCR using a primer mix specific for the DNA topoisomerase II gene.
Infections
Epidemiology of Neisseria gonorrhoeae Gyrase A Genotype, Los Angeles, California, USA.
Infections
Esterase-Catalyzed Siderophore Hydrolysis Activates an Enterobactin-Ciprofloxacin Conjugate and Confers Targeted Antibacterial Activity.
Infections
Evaluation of a New Chemotherapeutic: Cethromycin-Mediated Protection Against the Plague Pathogen, Yersinia pestis, in a Rat Model of Infection and its Comparison with Levofloxacin.
Infections
First-in-Human Evaluation of the Safety, Tolerability, and Pharmacokinetics of SPR720, a Novel Oral Bacterial DNA Gyrase (GyrB) Inhibitor for Mycobacterial Infections.
Infections
Genistein inhibits African swine fever virus replication in vitro by disrupting viral DNA synthesis.
Infections
Germline variations of the topoisomerase IIalpha gene as risk factors for primary gastric B-cell lymphoma.
Infections
Helicase ATPase activity of the Tobacco mosaic virus 126-kDa protein modulates replicase complex assembly.
Infections
Herpes Simplex Virus Capsid Localization to ESCRT-VPS4 Complexes in the Presence and Absence of the Large Tegument Protein UL36p.
Infections
Human cytomegalovirus induces expression of cellular topoisomerase II.
Infections
Human papillomavirus infection and expression of ATPase family AAA domain containing 3A, a novel anti-autophagy factor, in uterine cervical cancer.
Infections
Identification of novel biomarkers involved in pulmonary arterial hypertension based on multiple-microarray analysis.
Infections
In Vitro Activity of AZD0914, a Novel Bacterial DNA Gyrase/Topoisomerase IV Inhibitor, against Clinically Relevant Gram-Positive and Fastidious Gram-Negative Pathogens.
Infections
In vivo mapping of DNA topoisomerase II-specific cleavage sites on SV40 chromatin.
Infections
Incomplete cross-resistance of nalidixic and pipemidic acid-resistant variants of Serratia marcescens against ciprofloxacin, enoxacin, and norfloxacin.
Infections
Induction of defense responses by synthetic glycopeptides that have a partial structure of the elicitor in the spore germination fluid of Mycosphaerella pinodes.
Infections
Influence of bacterial kidney disease on smoltification in salmonids: is it a case of double jeopardy?
Infections
Influence of Vesicular-Arbuscular Mycorrhizal Fungi on the Response of Potato to Phosphorus Deficiency.
Infections
Inhibition of human immunodeficiency virus (HIV-1) replication in vitro by noncytotoxic doses of camptothecin, a topoisomerase I inhibitor.
Infections
Involvement of topoisomerases in replication, transcription, and packaging of the linear adenovirus genome.
Infections
Involvement of VCP/UFD1/Nucleolin in the viral entry of Enterovirus A species.
Infections
Irreversible inhibition of human cytomegalovirus replication by topoisomerase II inhibitor, etoposide: a new strategy for the treatment of human cytomegalovirus infection.
Infections
Isothiazoloquinolones with enhanced antistaphylococcal activities against multidrug-resistant strains: effects of structural modifications at the 6-, 7-, and 8-positions.
Infections
Kinetic Characterization of the Shigella Type Three Secretion System ATPase Spa47 Using ?-32P ATP.
Infections
Laboratory of genetics and physiology 2 (LGP2) plays an essential role in hepatitis C virus infection-induced interferon responses.
Infections
Lasiodiplodia theobromae (Pat.) Griff. & Maubl. reduced energy status and ATPase activity and its relation to disease development and pericarp browning of harvested longan fruit.
Infections
Legionella pneumophila infection is enhanced in a RacH-null mutant of Dictyostelium.
Infections
Lotus japonicus SUNERGOS1 encodes a predicted subunit A of a DNA topoisomerase VI and is required for nodule differentiation and accommodation of rhizobial infection.
Infections
Lymphangioma and congenital pulmonary lymphangiectasis: a histologic, immunohistochemical, and clinicopathologic comparison.
Infections
Membrane ATPase activation on infection of E. coli K (lambda) cells with phage T4rII mutants.
Infections
MsmK, an ATPase, Contributes to Utilization of Multiple Carbohydrates and Host Colonization of Streptococcus suis.
Infections
Nalidixic acid-resistant Salmonella enterica serotype typhi infection presenting with sub-intestinal obstruction and mesenteric adenitis.
Infections
New aminocoumarin antibiotics as gyrase inhibitors.
Infections
New developments in non-quinolone-based antibiotics for the inhibiton of bacterial gyrase and topoisomerase IV.
Infections
Non-proteolytic activity of 19S proteasome subunit RPT-6 regulates GATA transcription during response to infection.
Infections
Nonoptimal DNA topoisomerases allow maintenance of supercoiling levels and improve fitness of Streptococcus pneumoniae.
Infections
Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infections.
Infections
Nuclear subcompartmentalization of simian virus 40 large T antigen: evidence for in vivo regulation of biochemical activities.
Infections
Pharmacodynamic Evaluation of Dosing, Bacterial Kill, and Resistance Suppression for Zoliflodacin Against Neisseria gonorrhoeae in a Dynamic Hollow Fiber Infection Model.
Infections
Phase 2a Pharmacokinetic, Safety, and Exploratory Efficacy Evaluation of Oral Gepotidacin (GSK2140944) in Female Participants with Uncomplicated Urinary Tract Infection (Acute Uncomplicated Cystitis).
Infections
Probing linker design in citric acid-ciprofloxacin conjugates.
Infections
Prognostic markers of low-grade squamous intraepithelial lesions: the role of topoisomerase IIalpha and active caspase-3.
Infections
Purification and properties of a DNA-dependent ATPase induced by bacteriophage T4.
Infections
Purification of the gene 0.3 protein of bacteriophage T7, an inhibitor of the DNA restriction system of Escherichia coli.
Infections
Rac1 and Cdc42 GTPases cross-talk regulates formation of filopodia required for Dengue virus type-2 entry into HMEC-1 cells.
Infections
Recombinant ATPase of Virulent Aeromonas hydrophila Protects Channel Catfish Against Motile Aeromonas Septicemia.
Infections
Regulation of the mouse mammary tumor virus (MMTV) binding site in cultured mammary tissue.
Infections
Regulation of topoisomerase II alpha and beta in HIV-1 infected and uninfected neuroblastoma and astrocytoma cells: involvement of distinct nordihydroguaretic acid sensitive inflammatory pathways.
Infections
Restoration of diastolic function in senescent rat hearts through adenoviral gene transfer of sarcoplasmic reticulum Ca(2+)-ATPase.
Infections
Role of Agrobacterium VirB11 ATPase in T-pilus assembly and substrate selection.
Infections
Salmonella serotype Typhimurium infection of bovine Peyer's patches down-regulates plasma membrane calcium-transporting ATPase expression.
Infections
Simultaneous genital & oropharyngeal HPV-related infection with Topoisomerase IIa overexpression.
Infections
Single point mutations in the helicase domain of the NS3 protein enhance dengue virus replicative capacity in human monocyte-derived dendritic cells and circumvent the type I IFN response.
Infections
Structure-Based Mutagenesis of Sulfolobus Turreted Icosahedral Virus B204 Reveals Essential Residues in the Virion-Associated DNA-Packaging ATPase.
Infections
Substrate Interaction with the EssC Coupling Protein of the Type VIIb Secretion System.
Infections
Synthesis and biological activity of 5-amino- and 5-hydroxyquinolones, and the overwhelming influence of the remote N1-substituent in determining the structure-activity relationship.
Infections
Synthesis and evaluation of acridine- and acridone-based anti-herpes agents with topoisomerase activity.
Infections
Systematic Identification and Functional Analysis of Circular RNAs During Rice Black-Streaked Dwarf Virus Infection in the Laodelphax striatellus (Fallén) Midgut.
Infections
The African Swine Fever Virus (ASFV) Topoisomerase II as a Target for Viral Prevention and Control.
Infections
The agony of choice in dermatophyte diagnostics-performance of different molecular tests and culture in the detection of Trichophyton rubrum and Trichophyton interdigitale.
Infections
The cytochrome b5 tail anchors and stabilizes subdomains of human DNA topoisomerase II alpha in the cytoplasm of retrovirally infected mammalian cells.
Infections
The effect of interferon therapy on erythrocyte membrane Na+,K+ ATP activity in patients with chronic hepatitis B and C virus infections.
Infections
The effect of topoisomerase II inhibitors on the kinetoplast ultrastructure.
Infections
The Epstein-Barr virus deubiquitinating enzyme BPLF1 regulates the activity of topoisomerase II during productive infection.
Infections
The ESCRT-Related ATPase Vps4 Is Modulated by Interferon during Herpes Simplex Virus 1 Infection.
Infections
The Frequency of Discordant Gyrase A Genotypes Among Cases of Multiple Neisseria gonorrhoeae Infections at Different Anatomic Sites.
Infections
The frequency of DNA gyrase and topoisomerase IV mutations, and plasmid-mediated quinolone resistance genes among Escherichia coli and Klebsiella pneumoniae isolated from urinary tract infections in Azerbaijan, Iran.
Infections
The Golgi calcium ATPase pump plays an essential role in AAV trafficking and transduction.
Infections
The Inhibition of miR-144-3p on Cell Proliferation and Metastasis by Targeting TOP2A in HCMV-Positive Glioblastoma Cells.
Infections
The plastid-like organelle of apicomplexan parasites as drug target.
Infections
The role of energy-yielding ATPase and respiratory chain at early stages of bacteriophage T4 infection.
Infections
Tissue distribution of the cellular binding protein for the mouse mammary tumour virus.
Infections
Topoisomerase I and II cleavage of adenovirus DNA in vivo: both topoisomerase activities appear to be required for adenovirus DNA replication.
Infections
Topoisomerization of plasmid DNA in Escherichia coli infected with bacteriophage T4.
Infections
Transcriptional profiles of multiple genes in the anterior kidney of channel catfish vaccinated with an attenuated Aeromonas hydrophila.
Infections
Trypanosoma evansi: Ca(2+) ATPase activity and lipid peroxidation in skeletal muscle from rats experimentally infected.
Infections
Type VI Secretion System in Pseudomonas aeruginosa: SECRETION AND MULTIMERIZATION OF VgrG PROTEINS.
Infections
WQ-3810 exerts high inhibitory effect on quinolone-resistant DNA gyrase of Salmonella Typhimurium.
Infections
[A comparative analysis of energy process inhibitors on the efficiency of phage infection in staphylococci]
Infections
[Action of ATPase and muscle contraction modifiers on the initial stages of phage infection]
Infections
[Activity of bicozamycin against Escherichia coli O157:H7 producing Vero toxin]
Infections
[Changes in the ATPase activity of the plasma membranes of animal tissues in influenza infection]
Infections
[Ciprofloxacin and therapy of urinary tract infections, including those due to Staphylococcus saprophyticus]
Infections
[Current chemotherapy in urogenital infections. 4: Gyrase inhibitors]
Infections
[Gyrase inhibitor in pneumology. Ofloxacin--a new broad spectrum antibiotic in acute and chronic respiratory tract infections]
Infections
[Gyrase inhibitors, a new class of therapeutic drugs]
Infections
[Local treatment of Pseudomonas aeruginosa infection of the external ear canal with the gyrase inhibitor Tarivid]
Infections
[Mutations of DNA gyrase and topoisomerase IV in clinical isolates of fluoroquinolone-resistant Proteus mirabilis]
Infertility
A Role for Caenorhabditis elegans COMPASS in Germline Chromatin Organization.
Infertility
CASK interacts with PMCA4b and JAM-A on the mouse sperm flagellum to regulate Ca(2+) homeostasis and motility.
Infertility
Development and evaluation of sustained-release etoposide-loaded poly(?-caprolactone) implants.
Infertility
KATNAL1 regulation of sertoli cell microtubule dynamics is essential for spermiogenesis and male fertility.
Infertility
Optimisation and validation of a high throughput screening compatible assay to identify inhibitors of the plasma membrane calcium ATPase pump - a novel therapeutic target for contraception and malaria.
Infertility
[ATPase distribution in fertile and sterile anther of a genic male sterile Chinese cabbage]
Infertility, Male
Changes in soluble interleukin-2 receptor level in serum and Na+-K+-exchanging ATPase activity in semen of infertile men caused by antisperm antibody.
Infertility, Male
Identifying potential pitfalls in interpreting mitochondrial DNA mutations of male infertility cases.
Infertility, Male
[ATPase distribution in fertile and sterile anther of a genic male sterile Chinese cabbage]
Inflammatory Bowel Diseases
Targeted Inhibition of Heat Shock Protein 90 Suppresses Tumor Necrosis Factor-? and Ameliorates Murine Intestinal Inflammation.
Influenza, Human
A Viral Protein Mimics Histone to Hijack Host MORC3.
Influenza, Human
Concanamycin A: a powerful inhibitor of enveloped animal-virus entry into cells.
Influenza, Human
F1Fo-ATPase, F-type proton-translocating ATPase, at the plasma membrane is critical for efficient influenza virus budding.
Influenza, Human
Maoto, a Traditional Japanese Herbal Medicine, Inhibits Uncoating of Influenza Virus.
Influenza, Human
MORC3 Is a Target of the Influenza A Viral Protein NS1.
Influenza, Human
Sarco/Endoplasmic Reticulum Ca2+ Transporting ATPase (SERCA) Modulates Autophagic, Inflammatory, and Mitochondrial Responses during Influenza A Virus Infection in Human Lung Cells.
Influenza, Human
Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation.
Influenza, Human
[ATPase activity of the chorio-allantoic membrane of the chick embryo infected with influenza virus PR 8; effect of 1 (+) glutamic acid.]
Influenza, Human
[Changes in the ATPase activity of the plasma membranes of animal tissues in influenza infection]
Influenza, Human
[The action of cortisone on the ATPase activity of influenza virus PR8 during different stages of development.]
Insulin Resistance
Abnormal cation exchange in insulin-resistant patients with essential hypertension.
Insulin Resistance
Cardiac effects of caloric restriction-mechanisms and potential hazards.
Insulin Resistance
Changing Management Guidelines in Thyrotoxic Hypokalemic Periodic Paralysis.
Insulin Resistance
Different genes for obesity are associated with insulin loss of regulation of the membrane (Ca2+ + Mg2+)-ATPase in the obesity syndrome. Lessons from animal models.
Insulin Resistance
Glucocorticoids may trigger attacks in several types of periodic paralysis.
Insulin Resistance
Glucose oxidase induces insulin resistance via influencing multiple targets in vitro and in vivo: The central role of oxidative stress.
Insulin Resistance
Hormone-specific defect in insulin regulation of (Ca2+ + Mg2+)-adenosine triphosphatase activity in kidney membranes from streptozocin non-insulin-dependent diabetic rats.
Insulin Resistance
Insulin antagonistic effects of insulin receptor antibodies on plasma membrane (Ca2+ + Mg2+) ATPase activity: a possible etiology of type B insulin resistance.
Insulin Resistance
Membrane Na+ K+ ATPase inhibition related dyslipidemia and insulin resistance in neuropsychiatric disorders.
Insulin Resistance
Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction.
Insulin Resistance
OXIDATIVE STRESS IN CARDIOMYOCYTES CONTRIBUTES TO DECREASED SERCA2a ACTIVITY IN METABOLIC SYNDROME RATS.
Insulin Resistance
Stearoyl-CoA Desaturase-1 Is Associated with Insulin Resistance in Morbidly Obese Subjects.
Insulin Resistance
[Potential therapeutic approaches for prevention and treatment of diabetic nephropathy and neuropathy: evidences of cilostazol]
Intellectual Disability
Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration.
Intellectual Disability
Global developmental delay and intellectual disability associated with a de novo TOP2B mutation.
Intellectual Disability
Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4.
Intellectual Disability
Isolated Hearing Impairment Caused by SPATA5 Mutations in a Family with Variable Phenotypic Expression.
Intellectual Disability
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Intellectual Disability
Phenotype and genotype in Nicolaides-Baraitser syndrome.
Intellectual Disability
SPATA5 mutations cause a distinct autosomal recessive phenotype of intellectual disability, hypotonia and hearing loss.
Intervertebral Disc Displacement
Histochemistry and morphology of the multifidus muscle in lumbar disc herniation: comparative study between diseased and normal sides.
Intervertebral Disc Displacement
Muscle fiber type distribution in multifidus muscle in cases of lumbar disc herniation.
Intestinal Diseases
[Autoimmune reactions in gastrointestinal diseases]
Intestinal Obstruction
[Myosin B ATPase activity of the intestinal smooth muscle in intestinal obstruction]
Iron Deficiencies
Abnormalities in adenosine triphosphatase of the erythrocyte membrane in iron deficiency anaemia.
Iron Deficiencies
Enhanced Iron Uptake in Plants by Volatile Emissions of Rahnella aquatilis JZ-GX1.
Iron Deficiencies
Proteomic response to iron deficiency in tomato root.
Iron Overload
Restoring the impaired cardiac calcium homeostasis and cardiac function in iron overload rats by the combined deferiprone and N-acetyl cysteine.
Irritable Bowel Syndrome
Peculiarities of the effects of bile acids on atpase activity of the colon mucosa in patients with overweight and irritable bowel syndrome.
Ischemic Attack, Transient
Alterations of N-ethylmaleimide-sensitive atpase following transient cerebral ischemia.
Ischemic Contracture
Insulin worsens ischemia-induced myocardial contracture in the isolated rat heart.
Ischemic Contracture
Reversible elimination of myofibrillar Ca2+ sensitivity by diamide and other sulfhydryl reagents: comparison with reversible contracture produced in intact cells.
Ischemic Contracture
Role of dual-site phospholamban phosphorylation in intermittent hypoxia-induced cardioprotection against ischemia-reperfusion injury.
Kidney Failure, Chronic
Correlations between histochemical and ultrastructural studies of diseased muscle.
Kidney Failure, Chronic
Evaluation of peripheral metabolic status by determination of Na-K ATPase pump activity in circulating erythrocytes in patients with thyroid diseases and nonthyroidal illnesses.
Kidney Failure, Chronic
Light microscopic study of striated muscle in uremia.
Kidney Failure, Chronic
Marinobufagenin impairs first trimester cytotrophoblast differentiation.
Kidney Failure, Chronic
Mechanisms of PKC-Dependent Na K ATPase Phosphorylation in the Rat Kidney with Chronic Renal Failure.
Kidney Failure, Chronic
Membrane ATPase, erythrocyte sodium and potassium in haemodialysis patients.
Kidney Failure, Chronic
Mitochondrial DNA deletion of proximal tubules is the result of itai-itai disease.
Kidney Failure, Chronic
Red blood cell calcium homeostasis in patients with end-stage renal disease.
Kidney Failure, Chronic
Reduced activity of Na(+)-K+ ATPase of pancreatic islets in chronic renal failure: role of secondary hyperparathyroidism.
Kidney Failure, Chronic
[Clinical studies on assay for Na-K ATPase in human blood cells. I. Erythrocyte Na-K ATPase assay in patients with thyroid dysfunction and in those with chronic renal failure]
Kidney Failure, Chronic
[Concentration of adenine nucleotides in eryhrocytes and ATPase activity in erythrocyte ghosts during hemoperfusion and hemodialysis in patients with chronic renal failure]
Kidney Failure, Chronic
[Inhibition of transport ATPase in chronic kidney failure]
Kidney Neoplasms
Enzyme histochemistry in plastic-embedded sections of normal and diseased kidneys.
Kidney Neoplasms
Renal medullary carcinoma: molecular, pathological and clinical evidence for treatment with topoisomerase-inhibiting therapy.
Kidney Neoplasms
Synthesis and identification of novel indolo[2,3-a]pyrimido[5,4-c]carbazoles as a new class of anti-cancer agents.
Kidney Neoplasms
[A preliminary study to determine the activity of topoisomerase II in human kidney cancer cells with DNA unknotting method]
Kwashiorkor
Comparative action of calpain on erythrocyte Ca2(+)-pumping ATPase in sickle cell anaemia, essential hypertension and kwashiorkor.
Language Development Disorders
Characterization of a novel cation transporter ATPase gene (ATP13A4) interrupted by 3q25-q29 inversion in an individual with language delay.
Language Disorders
Recent advances in the genetics of language impairment.
Laryngeal Neoplasms
DNA topoisomerase II in therapy-related acute promyelocytic leukemia.
Laryngeal Neoplasms
Expression of topoisomerase II alpha, Ki-67 and p53 in early stage laryngeal carcinomas not featuring vocal cord fixation.
Leigh Disease
Comparative biochemical studies in fibroblasts from patients with different forms of Leigh syndrome.
Leigh Disease
DNA end labelling (TUNEL) in a 3 year old girl with Leigh syndrome and prevalent cortical involvement.
Leigh Disease
Leigh syndrome associated with the T9176C mutation in the ATPase 6 gene of mitochondrial DNA.
Leigh Disease
m.8993T>G-Associated Leigh Syndrome with Hypocitrullinemia on Newborn Screening.
Leigh Disease
Maternally Inherited Leigh Syndrome: T8993G Mutation in a Tunisian Family.
Leigh Disease
Maternally-inherited Leigh syndrome-related mutations bolster mitochondrial-mediated apoptosis.
Leigh Disease
Rescue of a deficiency in ATP synthesis by transfer of MTATP6, a mitochondrial DNA-encoded gene, to the nucleus.
Leigh Disease
Subacute necrotizing encephalopathy: oxidative phosphorylation defects and the ATPase 6 point mutation.
Leigh Disease
The 8993 mtDNA mutation: heteroplasmy and clinical presentation in three families.
Leigh Disease
The aleu207-->arg mutation in F1F0-ATP synthase from Escherichia coli. A model for human mitochondrial disease.
Leigh Disease
The T9176G mtDNA mutation severely affects ATP production and results in Leigh syndrome.
Leigh Disease
Two new mutations in the MTATP6 gene associated with Leigh syndrome.
Leiomyoma
Identification of a novel diagnostic gene expression signature to discriminate uterine leiomyoma from leiomyosarcoma.
Leiomyoma
Molecular differential analysis of uterine leiomyomas and leiomyosarcomas through weighted gene network and pathway tracing approaches.
Leiomyoma
[Topoisomerase IIalpha activity and tumor cell proliferation level from the degree of bromodeoxyuridine label in uterine body leiomyosarcoma].
Leiomyosarcoma
Expression of drug resistance related proteins in sarcomas of the pulmonary artery and poorly differentiated leiomyosarcomas of other origin.
Leiomyosarcoma
Expression of E-cadherin, beta-catenin and topoisomerase IIalpha in leiomyosarcomas.
Leiomyosarcoma
Identification of a novel diagnostic gene expression signature to discriminate uterine leiomyoma from leiomyosarcoma.
Leiomyosarcoma
Molecular differential analysis of uterine leiomyomas and leiomyosarcomas through weighted gene network and pathway tracing approaches.
Leiomyosarcoma
TOP2A copy number and TOP2A expression in uterine benign smooth muscle tumours and leiomyosarcoma.
Leiomyosarcoma
[Topoisomerase IIalpha activity and tumor cell proliferation level from the degree of bromodeoxyuridine label in uterine body leiomyosarcoma].
Leishmaniasis
Structure based investigation on the binding interaction of transport proteins in leishmaniasis: insights from molecular simulation.
Leishmaniasis, Visceral
Characterization of Leishmania chagasi DNA topoisomerase II: a potential chemotherapeutic target.
Leprosy
DNA gyrase could be a crucial regulatory factor for growth and survival of Mycobacterium leprae.
Leprosy
Mycobacterium marinum SecA2 Promotes Stable Granulomas and Induces Tumor Necrosis Factor Alpha In Vivo.
Leprosy
Strategies in the development of new drugs and drug combinations against leprosy, demonstrated on the example of folate and gyrase inhibitors.
Leprosy
Ultrastructural study of epidermal Langherhans cells in leprosy.
Leprosy, Tuberculoid
Preliminary observation on Langerhan's cells in leprosy.
Leukemia
1,4-Benzoquinone is a topoisomerase II poison.
Leukemia
11q23 aberration is an additional chromosomal change in de novo acute leukemia after treatment with etoposide and mitoxantrone.
Leukemia
11q23/MLL acute leukemia : update of clinical aspects.
Leukemia
1993 Robert R. deVilliers Lecture. Chromosome translocations: dangerous liaisons.
Leukemia
A "Double-Edged" Scaffold: Antitumor Power within the Antibacterial Quinolone.
Leukemia
A case of therapy-related acute myeloblastic leukemia with t(16;21)(q24;q22) after chemotherapy with DNA-topoisomerase II inhibitors, etoposide and mitoxantrone, and the alkylating agent, cyclophosphamide.
Leukemia
A cisplatin-resistant murine leukemia cell line exhibits increased topoisomerase II activity.
Leukemia
A comparative study of the cytotoxic and genotoxic effects of ICRF-154 and bimolane, two catalytic inhibitors of topoisomerase II.
Leukemia
A diazirine-based photoaffinity etoposide probe for labeling topoisomerase II.
Leukemia
A lack of a functional NAD(P)H:quinone oxidoreductase allele is selectively associated with pediatric leukemias that have MLL fusions. United Kingdom Childhood Cancer Study Investigators.
Leukemia
A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia.
Leukemia
A novel trial of topotecan, ifosfamide, and carboplatin (TIC) in children with recurrent solid tumors.
Leukemia
A restriction fragment length polymorphism for human topoisomerase II: possible relationship to drug-resistance.
Leukemia
A three-dimensional quantitative structure-activity analysis of a new class of bisphenol topoisomerase IIalpha inhibitors.
Leukemia
Aberrations in chromosomes associated with lymphoma and therapy-related leukemia in benzene-exposed workers.
Leukemia
Absence of topoisomerase IIbeta in an amsacrine-resistant human leukemia cell line with mutant topoisomerase IIalpha.
Leukemia
Activity of two novel anthracene-9,10-diones against human leukemia cells containing intercalator-sensitive or -resistant forms of topoisomerase II.
Leukemia
Acute leukemia presenting a variant Ph chromosome with p190 expression, dup 3q and -7, developed after malignant lymphoma treated with alkylating agents and topoisomerase II inhibitors.
Leukemia
Acute leukemias with the t(4;11)(q21;q23).
Leukemia
Acute promyelocytic leukemia after treatment for non-Hodgkin's lymphoma with drugs targeting topoisomerase II.
Leukemia
Acute promyelocytic leukemia with t(15;17) following inhibition of DNA topoisomerase II.
Leukemia
Adenovirus-mediated human topoisomerase IIalpha gene transfer increases the sensitivity of etoposide-resistant human and mouse breast cancer cells.
Leukemia
All patients with the T(11;16)(q23;p13.3) that involves MLL and CBP have treatment-related hematologic disorders.
Leukemia
ALL-1 gene rearrangements in DNA topoisomerase II inhibitor-related leukemia in children.
Leukemia
ALL1 gene alterations in acute leukemia: biological and clinical aspects.
Leukemia
Allelic fusion of DNA topoisomerase II alpha and retinoic acid receptor alpha genes in adriamycin-resistant p388 murine leukemia revealed by fluorescence in situ hybridization.
Leukemia
Alterations in the topoisomerase II alpha gene, messenger RNA, and subcellular protein distribution as well as reduced expression of the DNA topoisomerase II beta enzyme in a mitoxantrone-resistant HL-60 human leukemia cell line.
Leukemia
Altered DNA-cleavage activity of topoisomerase II from WEHI-3B leukemia cells with specific resistance to ciprofloxacin.
Leukemia
Altered expression and activity of topoisomerases during all-trans retinoic acid-induced differentiation of HL-60 cells.
Leukemia
Altered phosphorylation, biosynthesis and degradation of the 170 kDa isoform of topoisomerase II in amsacrine-resistant human leukemia cells.
Leukemia
Amonafide, a topoisomerase II inhibitor, is unaffected by P-glycoprotein-mediated efflux.
Leukemia
An in vivo topoisomerase II cleavage site and a DNase I hypersensitive site colocalize near exon 9 in the MLL breakpoint cluster region.
Leukemia
Analysis of t(15;17) chromosomal breakpoint sequences in therapy-related versus de novo acute promyelocytic leukemia: association of DNA breaks with specific DNA motifs at PML and RARA loci.
Leukemia
Analysis of topoisomerase II-mediated DNA cleavage of the c-myc gene during HL60 differentiation.
Leukemia
Antisense-mediated repression of DNA topoisomerase II expression leads to an impairment of HIV-1 replicative cycle.
Leukemia
Antitumor activity of ethyl 5-amino-1,2-dihydro-2-methyl-3-phenyl-pyrido [3,4-b]pyrazin-7-ylcarbamate, 2-hydroxyethanesulfonate, hydrate (NSC 370147) against selected tumor systems in culture and in mice.
Leukemia
Antitumor activity of mono- and dimetallic transition metal carborane complexes of Ta, Fe, Co, Mo, or W.
Leukemia
Are topoisomerase II inhibitor-induced micronuclei in vitro a predictive marker for the compounds' ability to cause secondary leukemias after treatment?
Leukemia
Arrest of replication fork progression at sites of topoisomerase II-mediated DNA cleavage in human leukemia CEM cells incubated with VM-26.
Leukemia
Ataxia telangiectasia mutated-dependent regulation of topoisomerase II alpha expression and sensitivity to topoisomerase II inhibitor.
Leukemia
ATM Modulates the Loading of Recombination Proteins onto a Chromosomal Translocation Breakpoint Hotspot.
Leukemia
ATPase inhibitors suppress actinomycin D-induced apoptosis in leukemia cells.
Leukemia
AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo.
Leukemia
B-cell acute lymphoblastic leukemia as a secondary malignancy following diffuse large B-cell lymphoma.
Leukemia
Balanced chromosome aberrations in leukemias following chemotherapy with DNA-topoisomerase II inhibitors.
Leukemia
Balanced translocations involving chromosome bands 11q23 and 21q22 are highly characteristic of myelodysplasia and leukemia following therapy with cytostatic agents targeting at DNA-topoisomerase II.
Leukemia
Bioflavonoids as poisons of human topoisomerase II alpha and II beta.
Leukemia
Bioflavonoids promote stable translocations between MLL-AF9 breakpoint cluster regions independent of normal chromosomal context: Model system to screen environmental risks.
Leukemia
Bufalin reduces the level of topoisomerase II in human leukemia cells and affects the cytotoxicity of anticancer drugs.
Leukemia
c-Myb trans-activates the human DNA topoisomerase IIalpha gene promoter.
Leukemia
Caffeine attenuates the action of amsacrine and etoposide in U-937 cells by mechanisms which involve inhibition of RNA synthesis.
Leukemia
Catalytic inhibition of human DNA topoisomerase IIalpha by hypericin, a naphthodianthrone from St. John's wort (Hypericum perforatum).
Leukemia
Cells lacking DNA topoisomerase II beta are resistant to genistein.
Leukemia
Characterization and mechanisms of chromosomal alterations induced by benzene in mice and humans.
Leukemia
Characterization of a DNA topoisomerase IIalpha gene rearrangement in adriamycin-resistant P388 leukemia: expression of a fusion messenger RNA transcript encoding topoisomerase IIalpha and the retinoic acid receptor alpha locus.
Leukemia
Characterization of a p30 fraction from Rauscher leukemia virus which has an associated ATPase activity.
Leukemia
Characterization of a subline of P388 leukemia resistant to amsacrine: evidence of altered topoisomerase II function.
Leukemia
Characterization of an amsacrine-resistant line of human leukemia cells. Evidence for a drug-resistant form of topoisomerase II.
Leukemia
Characterization of an etoposide-glutathione conjugate derived from metabolic activation by human cytochrome p450.
Leukemia
Characterization of genomic breakpoints in MLL and CBP in leukemia patients with t(11;16).
Leukemia
Characterization of therapy-related acute leukemia in hereditary breast-ovarian carcinoma patients: role of BRCA1 mutation and topoisomerase II-directed therapy.
Leukemia
Chemopreventive Potential of Flavonoid Extracts from Plantation-Bred and Wild Aronia melanocarpa (Black Chokeberry) Fruits
Leukemia
Chemotherapy of secondary leukemias.
Leukemia
Chemotherapy-related - late occurring - Philadelphia chromosome in AML, ALL and CML. Similar events related to treatment with DNA topoisomerase II inhibitors?
Leukemia
Chemotherapy-related acute promyelocytic leukemia: role of topoisomerase II.
Leukemia
Chemotherapy-related secondary acute myeloid leukemia in patients diagnosed with osteosarcoma.
Leukemia
Chemotherapy-related secondary leukemias: A role for DNA repair by error-prone non-homologous end joining in topoisomerase II - Induced chromosomal rearrangements.
Leukemia
Chromophore-modified bisnaphthalimides: DNA recognition, topoisomerase inhibition, and cytotoxic properties of two mono- and bisfuronaphthalimides.
Leukemia
Chromosome translocations: good genes gone wrong.
Leukemia
Circumvention of resistance by doxorubicin, but not by idarubicin, in a human leukemia cell line containing an intercalator-resistant form of topoisomerase II: evidence for a non-topoisomerase II-mediated mechanism of doxorubicin cytotoxicity.
Leukemia
Cleavage of the MLL gene by activators of apoptosis is independent of topoisomerase II activity.
Leukemia
Clonogenicity of human leukemic cells protected from cell-lethal agents by heat shock protein 70.
Leukemia
Clustering of genomic breakpoints at the MLL locus in therapy-related acute leukemia with t(4;11)(q21;q23).
Leukemia
Combination Chemotherapy of Azacitidine and Cetuximab for Therapy-Related Acute Myeloid Leukemia following Oxaliplatin for Metastatic Colorectal Cancer.
Leukemia
Common chromatin structures at breakpoint cluster regions may lead to chromosomal translocations found in chronic and acute leukemias.
Leukemia
Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia.
Leukemia
Computational analysis of Amsacrine resistance in human topoisomerase II alpha mutants (R487K and E571K) using homology modeling, docking and all-atom molecular dynamics simulation in explicit solvent.
Leukemia
Concentration-response studies of the chromosome-damaging effects of topoisomerase II inhibitors determined in vitro using human TK6 cells.
Leukemia
Concurrent translocations of MLL and CBFA2 (AML1) genes with new partner breakpoints in a child with secondary myelodysplastic syndrome after treatment of acute lymphoblastic leukemia.
Leukemia
Correlation between the DNA-binding affinity of topoisomerase inhibiting drugs and their capacity to induce hematopoetic cell differentiation.
Leukemia
Cross-resistance of an amsacrine-resistant human leukemia line to topoisomerase II reactive DNA intercalating agents. Evidence for two topoisomerase II directed drug actions.
Leukemia
Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells.
Leukemia
Cytotoxic efficacy with combinations of topoisomerase I and topoisomerase II inhibitors in sensitive and multidrug-resistant L1210 mouse leukemia cells.
Leukemia
Cytotoxicity and cell cycle effects of novel indolo[2,3-b]quinoline derivatives.
Leukemia
Decatenation: fixing your knots.
Leukemia
Decreased nuclear matrix DNA topoisomerase II in human leukemia cells resistant to VM-26 and m-AMSA.
Leukemia
Decreased nucleotide excision repair activity and alterations of topoisomerase IIalpha are associated with the in vivo resistance of a P388 leukemia subline to F11782, a novel catalytic inhibitor of topoisomerases I and II.
Leukemia
Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors.
Leukemia
Development of acute myeloid leukemia after chemotherapy for osteosarcoma.
Leukemia
Dicationic bis(9-methylphenazine-1-carboxamides): relationships between biological activity and linker chain structure for a series of potent topoisomerase targeted anticancer drugs.
Leukemia
Dietary flavonoids induce MLL translocations in primary human CD34+ cells.
Leukemia
Differential effect of camptothecin treatment on topoisomerase II alpha expression in ML-1 and HL-60 leukemia cell lines.
Leukemia
Differentiation of human promonocytic leukemia U-937 cells with DNA topoisomerase II inhibitors: induction of vimentin gene expression.
Leukemia
Differentiation of U-937 promonocytic cells by etoposide and ICRF-193, two antitumour DNA topoisomerase II inhibitors with different mechanisms of action.
Leukemia
Digitoxin, at concentrations commonly found in the plasma of cardiac patients, antagonizes etoposide and idarubicin activity in K562 leukemia cells.
Leukemia
Direct correlation between DNA topoisomerase II activity and cytotoxicity in adriamycin-sensitive and -resistant P388 leukemia cell lines.
Leukemia
Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites.
Leukemia
DNA interaction and cytotoxicity of a new series of indolo[2,3-b]quinoxaline and pyridopyrazino[2,3-b]indole derivatives.
Leukemia
DNA topoisomerase II immunostaining in human leukemia and rhabdomyosarcoma cell lines and their responses to topoisomerase II inhibitors.
Leukemia
DNA topoisomerase II in therapy-related acute promyelocytic leukemia.
Leukemia
DNA topoisomerase II inhibition by peroxisomicine A(1) and its radical metabolite induces apoptotic cell death of HL-60 and HL-60/MX2 human leukemia cells.
Leukemia
DNA topoisomerase II isozymes involved in anticancer drug action and resistance.
Leukemia
DNA-PK inhibitor peposertib enhances p53-dependent cytotoxicity of DNA double-strand break inducing therapy in acute leukemia.
Leukemia
Down-regulation of bcr-abl and bcl-x(L) expression in a leukemia cell line and its doxorubicin-resistant variant by topoisomerase II inhibitors.
Leukemia
Downregulation of MLL-CBP fusion gene expression is associated with differentiation of SN-1 cells with t(11;16)(q23;p13).
Leukemia
Doxazolidine induction of apoptosis by a topoisomerase II independent mechanism.
Leukemia
DR1-like element in human topoisomerase IIalpha gene involved in enhancement of etoposide-induced apoptosis by PPARgamma ligand.
Leukemia
Drug-induced changes in the expression of MDR-associated genes: investigations on cultured cell lines and chemotherapeutically treated leukemias.
Leukemia
Dual effect of the anti-allergic astemizole on Ca2+ fluxes in rat basophilic leukemia (RBL-2H3) cells: release of Ca2+ from intracellular stores and inhibition of Ca2+ release-activated Ca2+ influx.
Leukemia
Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations.
Leukemia
Effect of 1-beta-D-arabinofuranosylcytosine (ara-C) on nuclear topoisomerase II activity and on the DNA cleavage and cytotoxicity produced by 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) and etoposide in m-AMSA-sensitive and -resistant human leukemia cells.
Leukemia
Effect of bryostatin 1 on drug-induced, topoisomerase II-mediated DNA cleavage and topoisomerase II gene expression in human leukemia cells.
Leukemia
Effect of extracellular magnesium on topoisomerase II activity and expression in human leukemia HL-60 cells.
Leukemia
Effect of the calmodulin inhibitor trifluoperazine on phosphorylation of P-glycoprotein and topoisomerase II: relationship to modulation of subcellular distribution, DNA damage and cytotoxicity of doxorubicin in multidrug resistant L1210 mouse leukemia cells.
Leukemia
Effects of antileukemia agents on nuclear matrix-bound DNA replication in CCRF-CEM leukemia cells.
Leukemia
Effects of benzene metabolites on DNA cleavage mediated by human topoisomerase II alpha: 1,4-hydroquinone is a topoisomerase II poison.
Leukemia
Effects of topoisomerase I inhibition on the expression of topoisomerase II alpha measured with fluorescence image cytometry.
Leukemia
Energy-dependent efflux of methotrexate in L1210 leukemia cells. Evidence for the role of an ATPase obtained with inside-out plasma membrane vesicles.
Leukemia
Enhanced expression of DNA topoisomerase II by recombinant human granulocyte colony-stimulating factor in human leukemia cells.
Leukemia
Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance.
Leukemia
Etoposide and illegitimate DNA double-strand break repair in the generation of MLL translocations: New insights and new questions.
Leukemia
Etoposide Catechol Is an Oxidizable Topoisomerase II Poison.
Leukemia
Etoposide in the treatment of leukemias.
Leukemia
Etoposide induces chimeric Mll gene fusions.
Leukemia
Etoposide stimulates 1,25-dihydroxyvitamin D3 differentiation activity, hormone binding and hormone receptor expression in HL-60 human promyelocytic cells.
Leukemia
Etoposide-initiated MLL rearrangements detected at high frequency in human primitive hematopoietic stem cells with in vitro and in vivo long-term repopulating potential.
Leukemia
Evidence for a mutant allele of the gene for DNA topoisomerase II in adriamycin-resistant P388 murine leukemia cells.
Leukemia
Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia.
Leukemia
Excess transmission of the NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism in families of children with acute lymphoblastic leukemia.
Leukemia
Expression of acidosis-dependent genes in human cancer nests.
Leukemia
Expression of DNA topoisomerase II alpha and multidrug resistance p-glycoprotein in acute leukemia.
Leukemia
Expression of topoisomerase IIalpha in the G0/G1 cell cycle phase of fresh leukemic cells.
Leukemia
Further characterization of an amsacrine-resistant line of HL-60 human leukemia cells and its topoisomerase II. Effects of ATP concentration, anion concentration, and the three-dimensional structure of the DNA target.
Leukemia
Genistein induces topoisomerase IIbeta- and proteasome-mediated DNA sequence rearrangements: Implications in infant leukemia.
Leukemia
Genome-wide DNA methylation profiling of CpG islands in a morpholino anthracycline derivative-resistant leukemia cell line: p38? as a novel candidate for resistance.
Leukemia
Genome-wide TOP2A DNA cleavage is biased toward translocated and highly transcribed loci.
Leukemia
Genomic DNA breakpoints in AML1/RUNX1 and ETO cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemia.
Leukemia
Genotoxicity of benzene and its metabolites.
Leukemia
GPHN, a novel partner gene fused to MLL in a leukemia with t(11;14)(q23;q24).
Leukemia
Hepatic gene expression patterns following trauma-hemorrhage: effect of posttreatment with estrogen.
Leukemia
High risk of leukemia after short-term dose-intensive chemotherapy in young patients with solid tumors.
Leukemia
HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities.
Leukemia
Human LPP gene is fused to MLL in a secondary acute leukemia with a t(3;11) (q28;q23).
Leukemia
Hypophosphorylation of topoisomerase II in etoposide (VP-16)-resistant human leukemia K562 cells associated with reduced levels of beta II protein kinase C.
Leukemia
Hypothesis: phenol and hydroquinone derived mainly from diet and gastrointestinal flora activity are causal factors in leukemia.
Leukemia
Identification of a point mutation in the topoisomerase II gene from a human leukemia cell line containing an amsacrine-resistant form of topoisomerase II.
Leukemia
Impairment of Moloney murine leukemia virus integration in a cell line underexpressing DNA topoisomerase II.
Leukemia
Implication of prior treatment with drug combinations including inhibitors of topoisomerase II in therapy-related monocytic leukemia with a 9;11 translocation.
Leukemia
In vitro cleavage of the MLL gene by topoisomerase II inhibitor (etoposide) in normal cord and peripheral blood mononuclear cells.
Leukemia
Increase therapy-related leukemia secondary to breast cancer.
Leukemia
Increased rate of adenosine triphosphate-dependent etoposide (VP-16) efflux in a murine leukemia cell line overexpressing the multidrug resistance-associated protein (MRP) gene.
Leukemia
Increased risk of acute leukemia after adjuvant chemotherapy for breast cancer: a population-based study.
Leukemia
Induction of differentiation and DNA strand breakage in human HL-60 and K-562 leukemia cells by genistein.
Leukemia
Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.
Leukemia
Induction of the differentiation of WEHI-3B D+ monomyelocytic leukemia cells by inhibitors of topoisomerase II.
Leukemia
Infant acute leukemias show the same biased distribution of ALL1 gene breaks as topoisomerase II related secondary acute leukemias.
Leukemia
Infant leukemia, topoisomerase II inhibitors, and the MLL gene.
Leukemia
Infantile leukemia and soybeans--a hypothesis.
Leukemia
Inhibition of human topoisomerase II in vitro by bioactive benzene metabolites.
Leukemia
Inhibition of topoisomerase II by the marine alkaloid ascididemin and induction of apoptosis in leukemia cells.
Leukemia
Inhibitory effect of riccardin D on growth of human non-small cell lung cancer: In vitro and in vivo studies.
Leukemia
Is secondary leukemia an independent poor prognostic factor in acute myeloid leukemia?
Leukemia
Kinetics and regulation of cytochrome P450-mediated etoposide metabolism.
Leukemia
Late toxicity following curative treatment of testicular cancer.
Leukemia
Leukemia in infants.
Leukemia
Leukemia risk after adjuvant treatment of early breast cancer.
Leukemia
Leukemias related to treatment with DNA topoisomerase II inhibitors.
Leukemia
Loss of drug-stimulated topoisomerase II DNA breaks in living cells is different at two unrelated loci.
Leukemia
Maternal diet and infant leukemia: a role for DNA topoisomerase II inhibitors?
Leukemia
Maternal diet and infant leukemia: the DNA topoisomerase II inhibitor hypothesis: a report from the children's oncology group.
Leukemia
Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): a report from the Children's Cancer Group.
Leukemia
MDR1, MRP, topoisomerase IIalpha/beta, and cyclin A gene expression in acute and chronic leukemias.
Leukemia
Mitoxantrone resistance in HL-60 leukemia cells: reduced nuclear topoisomerase II catalytic activity and drug-induced DNA cleavage in association with reduced expression of the topoisomerase II beta isoform.
Leukemia
MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3).
Leukemia
MLL rearrangements are induced by low doses of etoposide in human fetal hematopoietic stem cells.
Leukemia
MLL/AF-1p fusion in therapy-related early pre-B acute lymphoblastic leukemia with t(1;11)(p32;q23) translocation developing in the relapse phase of acute promyelocytic leukemia.
Leukemia
Molecular analysis of 13 cases of MLL/11q23 secondary acute leukemia and identification of topoisomerase II consensus-binding sequences near the chromosomal breakpoint of a secondary leukemia with the t(4;11).
Leukemia
Molecular analysis of a potentially phorbol-regulatable region of the human topoisomerase II alpha gene promoter.
Leukemia
Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis.
Leukemia
Molecular effects of topoisomerase II inhibitors in AML cell lines: correlation of apoptosis with topoisomerase II activity but not with DNA damage.
Leukemia
Monitoring uptake of ellipticine and its fluorescence lifetime in relation to the cell cycle phase by flow cytometry.
Leukemia
Multifactorial resistance to antineoplastic agents in drug-resistant P388 murine leukemia, Chinese hamster ovary, and human HeLa cells, with emphasis on the role of DNA topoisomerase II.
Leukemia
Multilocus association of genetic variants in MLL, CREBBP, EP300, and TOP2A with childhood acute lymphoblastic leukemia in Hispanics from Texas.
Leukemia
Multiple resistance mechanisms in acute nonlymphoblastic leukemia (ANLL).
Leukemia
Mutation frequency and spectrum in lymphocytes of small cell lung cancer patients receiving etoposide chemotherapy.
Leukemia
Myelodysplasias and leukemias after autologous stem cell transplantation for lymphoid malignancies.
Leukemia
Myeloid leukemia after hematotoxins.
Leukemia
N-acetyl-p-benzoquinone imine, the toxic metabolite of acetaminophen, is a topoisomerase II poison.
Leukemia
Na+/K+ ATPase inhibitors in cancer.
Leukemia
NF-M trans-activates the human DNA topoisomerase II alpha promoter independently of c-Myb in HL-60 cells.
Leukemia
Novel MLL-CBP fusion transcript in therapy-related chronic myelomonocytic leukemia with a t(11;16)(q23;p13) chromosome translocation.
Leukemia
Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11) (p21;q23).
Leukemia
Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II ? over ?.
Leukemia
Novobiocin- and phorbol-12-myristate-13-acetate-induced differentiation of human leukemia cells associated with a reduction in topoisomerase II activity.
Leukemia
Nucleolytic cleavage of the mixed lineage leukemia breakpoint cluster region during apoptosis.
Leukemia
Overexpression of P-glycoprotein and alterations in topoisomerase II in P388 mouse leukemia cells selected in vivo for resistance to mitoxantrone.
Leukemia
Overexpression of the atypical protein kinase C zeta reduces topoisomerase II catalytic activity, cleavable complexes formation, and drug-induced cytotoxicity in monocytic U937 leukemia cells.
Leukemia
Panhandle PCR approaches to cloning MLL genomic breakpoint junctions and fusion transcript sequences.
Leukemia
Panhandle PCR: a technical advance to amplify MLL genomic translocation breakpoints.
Leukemia
Phase I trial of sequential topotecan followed by etoposide in adults with myeloid leukemia: a National Cancer Institute of Canada Clinical Trials Group Study.
Leukemia
Phorbol ester effects on topoisomerase II activity and gene expression in HL-60 human leukemia cells with different proclivities toward monocytoid differentiation.
Leukemia
Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity.
Leukemia
Polymorphisms in the MLL breakpoint cluster region (BCR).
Leukemia
Potentiation by novobiocin of the cytotoxic activity of etoposide (VP-16) and teniposide (VM-26).
Leukemia
Preferential induction of MLL(Mixed Lineage Leukemia) rearrangements in human lymphocyte cultures treated with etoposide.
Leukemia
Progressive resistance to doxorubicin in mouse leukemia L1210 cells with multidrug resistance phenotype: reductions in drug-induced topoisomerase II-mediated DNA cleavage.
Leukemia
Purification of topoisomerase II from amsacrine-resistant P388 leukemia cells. Evidence for two forms of the enzyme.
Leukemia
Qualitative and quantitative characterization of Fas (CD95) expression and its role in primary human acute leukemia cells.
Leukemia
Quercetin alters the DNA damage response in human hematopoietic stem and progenitor cells via TopoII- and PI3K-dependent mechanisms synergizing in leukemogenic rearrangements.
Leukemia
Quercetin Triggers Induction of Apoptotic and Lysosomal Death of Sensitive and Multidrug Resistant Leukaemia HL60 Cells.
Leukemia
Rapid increase in the activity of DNA topoisomerase I, but not topoisomerase II, in HL-60 promyelocytic leukemia cells treated with a phorbol diester.
Leukemia
Rare t(1;11)(q23;p15) in therapy-related myelodysplastic syndrome evolving into acute myelomonocytic leukemia: a case report and review of the literature.
Leukemia
RAS mutations in pediatric leukemias with MLL gene rearrangements.
Leukemia
Rearrangement of the Myeloid/Lymphoid Leukemia Gene in Therapy-Related Myelodysplastic Syndrome in Patients Previously Treated with Agents Targeting DNA Topoisomerase II.
Leukemia
Rearrangements of the MLL gene are influenced by DNA secondary structure, potentially mediated by topoisomerase II binding.
Leukemia
Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA-topoisomerase II.
Leukemia
Reciprocal DNA topoisomerase II cleavage events at 5'-TATTA-3' sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing.
Leukemia
Reduced phosphorylation of topoisomerase II in etoposide-resistant human leukemia K562 cells.
Leukemia
Relative activity of structural analogues of amsacrine against human leukemia cell lines containing amsacrine-sensitive or -resistant forms of topoisomerase II: use of computer simulations in new drug development.
Leukemia
Resistance factors and proliferative activity in childhood acute nonlymphoblastic leukemia.
Leukemia
Resistance to etoposide in human leukemia HL-60 cells: reduction in drug-induced DNA cleavage associated with hypophosphorylation of topoisomerase II phosphopeptides.
Leukemia
Riccardin D, a novel macrocyclic bisbibenzyl, induces apoptosis of human leukemia cells by targeting DNA topoisomerase II.
Leukemia
Role of DNA intercalation in the inhibition of purified mouse leukemia (L1210) DNA topoisomerase II by 9-aminoacridines.
Leukemia
Second cancers after breast cancer treatment.
Leukemia
Second malignancies following adjuvant chemotherapy: 6-year results from a Belgian randomized study comparing cyclophosphamide, methotrexate and 5-fluorouracil (CMF) with an anthracycline-based regimen in adjuvant treatment of node-positive breast cancer patients.
Leukemia
Secondary acute promyelocytic leukemia following chemotherapy for non-Hodgkin's lymphoma in a child.
Leukemia
Secondary Leukemia Associated with the Anti-Cancer Agent, Etoposide, a Topoisomerase II Inhibitor.
Leukemia
Secondary leukemias induced by topoisomerase-targeted drugs.
Leukemia
Selective inhibition of topoisomerase II by ICRF-193 does not support a role for topoisomerase II activity in the fragmentation of chromatin during apoptosis of human leukemia cells.
Leukemia
Selective sensitization of adriamycin-resistant P388 murine leukemia cells to antineoplastic agents following transfection with human DNA topoisomerase II alpha.
Leukemia
Selective use of an alternative stop codon and polyadenylation signal within intron sequences leads to a truncated topoisomerase II alpha messenger RNA and protein in human HL-60 leukemia cells selected for resistance to mitoxantrone.
Leukemia
Seminars from the University of Minnesota. Chromosome translocations: dangerous liaisons.
Leukemia
Sensitivity to TOP2 Targeting Chemotherapeutics Is Regulated by Oct1 and FILIP1L.
Leukemia
Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors.
Leukemia
Small-molecule inhibitors targeting eIF4A in leukemia.
Leukemia
Spontaneous DNA lesions poison human topoisomerase IIalpha and stimulate cleavage proximal to leukemic 11q23 chromosomal breakpoints.
Leukemia
Stimulation of topoisomerase II-mediated DNA cleavage by benzene metabolites.
Leukemia
Stimulation of topoisomerase II-mediated DNA cleavage by three DNA-intercalating plant alkaloids: cryptolepine, matadine, and serpentine.
Leukemia
Structure-activity studies of amsacrine analogs in drug resistant human leukemia cell lines expressing either altered DNA topoisomerase II or P-glycoprotein.
Leukemia
Structure-activity studies of novobiocin analogs as modulators of the cytotoxicity of etoposide (VP-16).
Leukemia
Subcellular distribution of the alpha and beta topoisomerase II-DNA complexes stabilized by VM-26.
Leukemia
Synergism between etoposide and 17-AAG in leukemia cells: critical roles for Hsp90, FLT3, topoisomerase II, Chk1, and Rad51.
Leukemia
Synthesis and antitumor properties of N-[2-(dimethylamino)ethyl]carboxamide derivatives of fused tetracyclic quinolines and quinoxalines: a new class of putative topoisomerase inhibitors.
Leukemia
Synthesis and cytotoxicity of oligomycin A derivatives modified in the side chain.
Leukemia
Synthesis of 2-aryl-4-(benzimidazol-2-yl)-1,2-dihydro[1,2,4]triazino-[4,5-a]benzimidazol-1-one derivatives with preferential cytotoxicity against carcinoma cell lines.
Leukemia
T-Cell Protein Tyrosine Phosphatase Is Irreversibly Inhibited by Etoposide-Quinone, a Reactive Metabolite of the Chemotherapy Drug Etoposide.
Leukemia
Targeting Topoisomerase II Activity in NSCLC with 9-Aminoacridine Derivatives.
Leukemia
Telomerase inhibition is a specific early event in salvicine-treated human lung adenocarcinoma A549 cells.
Leukemia
The anticancer multi-kinase inhibitor dovitinib also targets topoisomerase I and topoisomerase II.
Leukemia
The balanced and the unbalanced chromosome aberrations of acute myeloid leukemia may develop in different ways and may contribute differently to malignant transformation.
Leukemia
The catalytic DNA topoisomerase II inhibitor dexrazoxane (ICRF-187) induces differentiation and apoptosis in human leukemia K562 cells.
Leukemia
The catalytic DNA topoisomerase II inhibitor ICRF-193 and all-trans retinoic acid cooperatively induce granulocytic differentiation of acute promyelocytic leukemia cells: candidate drugs for chemo-differentiation therapy against acute promyelocytic leukemia.
Leukemia
The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERCA inhibition, oxidative stress, and interference with Notch1 signaling.
Leukemia
The co-presence of deletion 7q, 20q and inversion 16 in therapy-related acute myeloid leukemia developed secondary to treatment of breast cancer with cyclophosphamide, doxorubicin, and radiotherapy: a case report.
Leukemia
The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells.
Leukemia
The effect of 9-beta-D-arabinofuranosyl-2-fluoroadenine and 1-beta-D-arabinofuranosylcytosine on the cell cycle phase distribution, topoisomerase II level, mitoxantrone cytotoxicity, and DNA strand break production in K562 human leukemia cells.
Leukemia
The incidence of secondary leukemias.
Leukemia
The interaction between nuclear topoisomerase II activity from human leukemia cells, exogenous DNA, and 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) or 4-(4,6-O-ethylidene-beta-D-glucopyranoside) (VP-16) indicates the sensitivity of the cells to the drugs.
Leukemia
The p53 gene in pediatric therapy-related leukemia and myelodysplasia.
Leukemia
The role of topoisomerase II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI1.
Leukemia
The structure and function of NKAIN2-a candidate tumor suppressor.
Leukemia
The topoisomerase II inhibitor voreloxin causes cell cycle arrest and apoptosis in myeloid leukemia cells and acts in synergy with cytarabine.
Leukemia
Therapy-related acute leukemia associated with involvement of 11q23 after high grade non-Hodgkin lymphoma.
Leukemia
Therapy-related acute promyelocytic leukemia with t(15;17) (q22;q12) following chemotherapy with drugs targeting DNA topoisomerase II. A report of two cases and a review of the literature.
Leukemia
Therapy-related leukemia and myelodysplastic syndrome: a large-scale Japanese study of clinical and cytogenetic features as well as prognostic factors.
Leukemia
Therapy-related malignancies following treatment of germ cell cancer.
Leukemia
Therapy-related myelodysplasia and acute myeloid leukemia. Cytogenetic characteristics of 115 consecutive cases and risk in seven cohorts of patients treated intensively for malignant diseases in the Copenhagen series.
Leukemia
Therapy-related myeloid leukemia.
Leukemia
Therapy-related myeloid malignancies in myeloma.
Leukemia
THERAPY-RELATED T/MYELOID MIXED PHENOTYPE ACUTE LEUKEMIA IN A PATIENT TREATED WITH CHEMOTHERAPY FOR CUTANEOUS DIFFUSE LARGE B CELL LYMPHOMA.
Leukemia
Therapy-related, mixed phenotype acute leukemia with t(1;21)(p36;q22) and RUNX1 rearrangement.
Leukemia
Thyroid hormone-induced stimulation of the sarcoplasmic reticulum Ca(2+) ATPase gene is inhibited by LIF and IL-6.
Leukemia
Time course of phorbol-12-myristate-13-acetate (PMA)-induced down-regulation of topoisomerase II in human leukemia cells.
Leukemia
Topoisomerase II alpha gene expression in childhood acute lymphoblastic leukemia.
Leukemia
Topoisomerase II alpha promoter trans-activation early in monocytic differentiation of HL-60 human leukemia cells.
Leukemia
Topoisomerase II and leukemia.
Leukemia
Topoisomerase II and the etiology of chromosomal translocations.
Leukemia
Topoisomerase II and the response to antileukemic therapy.
Leukemia
Topoisomerase II as a target of antileukemic drugs.
Leukemia
Topoisomerase II inhibition by myeloperoxidase-activated hydroquinone: a potential mechanism underlying the genotoxic and carcinogenic effects of benzene.
Leukemia
Topoisomerase II inhibition by the bioactivated benzene metabolite hydroquinone involves multiple mechanisms.
Leukemia
Topoisomerase II inhibitor induced leukemia in a patient with AIDS.
Leukemia
Topoisomerase II is required for mitoxantrone to signal nuclear factor kappa B activation in HL60 cells.
Leukemia
Topoisomerase II levels during granulocytic maturation in vitro and in vivo.
Leukemia
Topoisomerase II{alpha} amplification does not predict benefit from dose-intense cyclophosphamide, doxorubicin, and fluorouracil therapy in HER2-amplified early breast cancer: results of CALGB 8541/150013.
Leukemia
Transcriptional down-regulation of c-myc expression in an erythroleukemic cell line, K562, and its doxorubicin-resistant variant by two topoisomerase II inhibitors, doxorubicin and amsacrine.
Leukemia
Translocation (3;21)(q26;q22) in treatment-related acute leukemia secondary to acute promyelocytic leukemia.
Leukemia
Translocation (4;11)(p12;q23) with rearrangement of FRYL and MLL in therapy-related acute myeloid leukemia.
Leukemia
Transplacental chemical exposure and risk of infant leukemia with MLL gene fusion.
Leukemia
Treatment of refractory acute leukemia with timed sequential chemotherapy using topotecan followed by etoposide + mitoxantrone (T-EM) and correlation with topoisomerase II levels.
Leukemia
Treatment-related leukemia in breast cancer patients treated with fluorouracil-doxorubicin-cyclophosphamide combination adjuvant chemotherapy: the University of Texas M.D. Anderson Cancer Center experience.
Leukemia
Trifluoperazine modulation of resistance to the topoisomerase II inhibitor etoposide in doxorubicin resistant L1210 murine leukemia cells.
Leukemia
Tumor heterogeneity at protein level as an independent prognostic factor in endometrial cancer.
Leukemia
Two different classes of therapy-related and de-novo acute myeloid leukemia?
Leukemia
Two independent amsacrine-resistant human myeloid leukemia cell lines share an identical point mutation in the 170 kDa form of human topoisomerase II.
Leukemia
XK469, a selective topoisomerase IIbeta poison.
Leukemia
Yi-qi-yang-yin-tang increases the sensitivity of KG1a leukemia stem cells to daunorubicin by promoting cell cycle progression and regulating the expression of PTEN, TOPOII and mTOR.
Leukemia
[Blood ATPase in patients with leukemia.]
Leukemia
[Chromosome translocations and leukemias induced by inhibitors of topoisomerase II anticarcinogenic drugs]
Leukemia
[Complication of topoisomerase II inhibitor-related acute promyelocytic leukemia with t(1;10) (q21;q26) in a patient with Sézary syndrome]
Leukemia
[Expressions of P-gp, mdr1, MRP and Topo II in acute leukemia patients and their correlation with prognosis]
Leukemia
[Mechanism of occurrence of secondary tumors by antitumor drugs]
Leukemia
[Mechanisms of drug resistance of two cell lines of human chronic promyelocytic leukemia K562, resistant to DNA topoisomerase II inhibitors adriamycin and etoposide]
Leukemia
[Membrane ATPase and erythrocyte cations in acute leukemia]
Leukemia
[Radiation-induced and therapy-related AML/MDS]
Leukemia
[Secondary leukemias: their clinical features, incidence among populations at risk, mechanisms and new strategy for prediction]
Leukemia
[Study on the relationship between DNA topoisomerase II activity and multidrug resistance in leukemic cells]
Leukemia
[The correlation of cyclin A gene expression with drug resistance in adult acute leukemia patients]
Leukemia
[The relationship between cyclin B1 and multidrug resistance in adult patients with acute leukemia]
Leukemia
[Therapy related leukemia with 11q23 abnormality induced by chemotherapy consisted of docetaxel for advanced prostatic carcinoma: case report]
Leukemia
[Therapy-related AML(M2) with t(8;21) that developed three years after chemotherapy for hepatocellular carcinoma]
Leukemia
[Therapy-related chronic myelogenous leukemia following RFM therapy in a patient with follicular lymphoma].
Leukemia L1210
A comparative study on cytotoxicities and biochemical properties of anthraquinone mycotoxins emodin and skyrin from Penicillium islandicum Sopp.
Leukemia L1210
Determination of DNA topoisomerase II activity from L1210 cells--a target for screening antitumor agents.
Leukemia L1210
Effects of the bifunctional antitumor intercalator ditercalinium on DNA in mouse leukemia L1210 cells and DNA topoisomerase II.
Leukemia L1210
Proliferation dependence of topoisomerase II mediated drug action.
Leukemia L1210
Proliferation-dependent topoisomerase II content as a determinant of antineoplastic drug action in human, mouse, and Chinese hamster ovary cells.
Leukemia L1210
Role of DNA intercalation in the inhibition of purified mouse leukemia (L1210) DNA topoisomerase II by 9-aminoacridines.
Leukemia L1210
Role of proliferation in determining sensitivity to topoisomerase II-active chemotherapy agents.
Leukemia P388
Antitumor activity of ER-37328, a novel carbazole topoisomerase II inhibitor.
Leukemia P388
Apoptosis induced by anthracycline antibiotics in P388 parent and multidrug-resistant cells.
Leukemia P388
Overexpression of P-glycoprotein and alterations in topoisomerase II in P388 mouse leukemia cells selected in vivo for resistance to mitoxantrone.
Leukemia P388
[Topoisomerase II mediated DNA strand cleavage and antitumor activities against murine leukemia P388 of novel acridines]
Leukemia, Erythroblastic, Acute
Commitment to erythroid differentiation in mouse erythroleukemia cells is controlled by alterations in topoisomerase II alpha phosphorylation.
Leukemia, Erythroblastic, Acute
Influence of different metal ions on the ultrastructure, biochemical properties, and protein localization of the K562 cell nuclear matrix.
Leukemia, Erythroblastic, Acute
Localisation of DNA topoisomerase IIalpha in mouse erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Phorbol ester-induced down-regulation of topoisomerase II alpha mRNA in a human erythroleukemia cell line. Evidence for a post-transcriptional mechanism.
Leukemia, Erythroblastic, Acute
Regulation of DNA synthesis by the higher-order chromatin structure.
Leukemia, Erythroblastic, Acute
Regulation of topoisomerase II expression during the VM-26 induced differentiation of IW32 murine erythroleukemia cells.
Leukemia, Erythroblastic, Acute
Structurally modified anthracyclines retain activity in a cell line with simultaneous typical and atypical multidrug resistance.
Leukemia, Erythroblastic, Acute
The histone deacetylase inhibitor sodium butyrate induces DNA topoisomerase II alpha expression and confers hypersensitivity to etoposide in human leukemic cell lines.
Leukemia, Lymphocytic, Chronic, B-Cell
Drug resistance mechanisms in chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Drug resistance to DNA topoisomerase I and II inhibitors in human leukemia, lymphoma, and multiple myeloma.
Leukemia, Lymphoid
Cytotoxic action of carboxyborane heterocyclic amine adducts.
Leukemia, Lymphoid
Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations.
Leukemia, Lymphoid
[Chromosome translocations and leukemias induced by inhibitors of topoisomerase II anticarcinogenic drugs]
Leukemia, Monocytic, Acute
Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11) (p21;q23).
Leukemia, Monocytic, Acute
The co-presence of deletion 7q, 20q and inversion 16 in therapy-related acute myeloid leukemia developed secondary to treatment of breast cancer with cyclophosphamide, doxorubicin, and radiotherapy: a case report.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Comparison of caspase activation and subcellular localization in HL-60 and K562 cells undergoing etoposide-induced apoptosis.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Selective and effective targeting of chronic myeloid leukemia stem cells by topoisomerase II inhibitor etoposide in combination with imatinib mesylate in vitro.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Topoisomerase II beta levels are a determinant of melphalan-induced DNA crosslinks and sensitivity to cell death.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Topotecan-induced topoisomerase IIalpha expression increases the sensitivity of the CML cell line K562 to subsequent etoposide plus mitoxantrone treatment.
Leukemia, Myeloid
Acute promyelocytic leukemic involvement of the optic nerves following mitoxantrone treatment for multiple sclerosis.
Leukemia, Myeloid
CBFA2(AML1) translocations with novel partner chromosomes in myeloid leukemias: association with prior therapy.
Leukemia, Myeloid
Different mechanisms for suppression of apoptosis by cytokines and calcium mobilizing compounds.
Leukemia, Myeloid
Downregulation of topoisomerase IIbeta in myeloid leukemia cell lines leads to activation of apoptosis following all-trans retinoic acid-induced differentiation/growth arrest.
Leukemia, Myeloid
Epigenetic Combination Therapy for Children With Secondary Myelodysplastic Syndrome (MDS)/Acute Myeloid Leukemia (AML) and Concurrent Solid Tumor Relapse.
Leukemia, Myeloid
Expression of wild-type p53 increases etoposide cytotoxicity in M1 myeloid leukemia cells by facilitated G2 to M transition: implications for gene therapy.
Leukemia, Myeloid
Inhibition of topoisomerase II by 8-chloro-adenosine triphosphate induces DNA double-stranded breaks in 8-chloro-adenosine-exposed human myelocytic leukemia K562 cells.
Leukemia, Myeloid
Interaction of CJY, an Isoflavone, with ATPase of P-glycoprotein in Doxorubicin-resistant Human Myelogenous Leukemia (K562/DOX) Cells.
Leukemia, Myeloid
Interaction of CJZ3, a lomerizine derivative, with ATPase activity of human P-glycoprotein in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells.
Leukemia, Myeloid
Rearrangement of the AML1/CBFA2 gene in myeloid leukemia with the 3;21 translocation: expression of co-existing multiple chimeric genes with similar functions as transcriptional repressors, but with opposite tumorigenic properties.
Leukemia, Myeloid
Rearrangements of the AML1/CBFA2 gene in myeloid leukemia with the 3;21 translocation: in vitro and in vivo studies.
Leukemia, Myeloid
The histone deacetylase inhibitor sodium butyrate induces DNA topoisomerase II alpha expression and confers hypersensitivity to etoposide in human leukemic cell lines.
Leukemia, Myeloid
The topoisomerase II inhibitor voreloxin causes cell cycle arrest and apoptosis in myeloid leukemia cells and acts in synergy with cytarabine.
Leukemia, Myeloid
Therapy-related myeloid leukemia.
Leukemia, Myeloid
Two independent amsacrine-resistant human myeloid leukemia cell lines share an identical point mutation in the 170 kDa form of human topoisomerase II.
Leukemia, Myeloid, Acute
A case of therapy-related acute myeloblastic leukemia with t(16;21)(q24;q22) after chemotherapy with DNA-topoisomerase II inhibitors, etoposide and mitoxantrone, and the alkylating agent, cyclophosphamide.
Leukemia, Myeloid, Acute
A Case of Therapy-related Acute Myeloid Leukemia Following Treatment with 5-Fluorouracil.
Leukemia, Myeloid, Acute
Amplification of ERBB2, RARA, and TOP2A genes in a myelodysplastic syndrome transforming to acute myeloid leukemia.
Leukemia, Myeloid, Acute
An in vivo topoisomerase II cleavage site and a DNase I hypersensitive site colocalize near exon 9 in the MLL breakpoint cluster region.
Leukemia, Myeloid, Acute
Are topoisomerase II inhibitor-induced micronuclei in vitro a predictive marker for the compounds' ability to cause secondary leukemias after treatment?
Leukemia, Myeloid, Acute
Assessing acute myeloid leukemia susceptibility in rearrangement-driven patients by DNA breakage at topoisomerase II and CCCTC-binding factor/cohesin binding sites.
Leukemia, Myeloid, Acute
Association of Chemotherapy for Solid Tumors With Development of Therapy-Related Myelodysplastic Syndrome or Acute Myeloid Leukemia in the Modern Era.
Leukemia, Myeloid, Acute
Association of immunophenotype with expression of topoisomerase II ? and ? in adult acute myeloid leukemia.
Leukemia, Myeloid, Acute
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.
Leukemia, Myeloid, Acute
Benzene metabolites antagonize etoposide-stabilized cleavable complexes of DNA topoisomerase IIalpha.
Leukemia, Myeloid, Acute
Chemotherapy-related - late occurring - Philadelphia chromosome in AML, ALL and CML. Similar events related to treatment with DNA topoisomerase II inhibitors?
Leukemia, Myeloid, Acute
Chromosomal abnormalities in secondary MDS and AML. Relationship to drugs and radiation with specific emphasis on the balanced rearrangements.
Leukemia, Myeloid, Acute
Cloning and sequence analysis of four t(9;11) therapy-related leukemia breakpoints.
Leukemia, Myeloid, Acute
Concurrent Presentation of Therapy Related Acute Myeloid Leukemia in a Case of Neuroblastoma.
Leukemia, Myeloid, Acute
Concurrent translocations of MLL and CBFA2 (AML1) genes with new partner breakpoints in a child with secondary myelodysplastic syndrome after treatment of acute lymphoblastic leukemia.
Leukemia, Myeloid, Acute
Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites.
Leukemia, Myeloid, Acute
DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis.
Leukemia, Myeloid, Acute
DNA-protein cross-link levels in bone marrow cells of mice treated with benzene or trans,trans-muconaldehyde.
Leukemia, Myeloid, Acute
Drivers of topoisomerase II poisoning mimic and complement cytotoxicity in AML cells.
Leukemia, Myeloid, Acute
Drug resistance to DNA topoisomerase I and II inhibitors in human leukemia, lymphoma, and multiple myeloma.
Leukemia, Myeloid, Acute
Effects of topoisomerase I inhibition on the expression of topoisomerase II alpha measured with fluorescence image cytometry.
Leukemia, Myeloid, Acute
Enhanced expression of DNA topoisomerase II by recombinant human granulocyte colony-stimulating factor in human leukemia cells.
Leukemia, Myeloid, Acute
Etoposide in the treatment of leukemias.
Leukemia, Myeloid, Acute
Etoposide sensitivity does not predict MLL rearrangements or risk of therapy-related acute myeloid leukemia.
Leukemia, Myeloid, Acute
Ex vivo effects of the dual topoisomerase inhibitor tafluposide (F 11782) on cells isolated from fresh tumor samples taken from patients with cancer.
Leukemia, Myeloid, Acute
Excess transmission of the NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism in families of children with acute lymphoblastic leukemia.
Leukemia, Myeloid, Acute
Expression of PKC isozyme and MDR-associated genes in primary and relapsed state AML.
Leukemia, Myeloid, Acute
FLT3 and MLL intragenic abnormalities in AML reflect a common category of genotoxic stress.
Leukemia, Myeloid, Acute
Genetics of therapy-related myelodysplasia and acute myeloid leukemia.
Leukemia, Myeloid, Acute
Glutathione system, topoisomerase II level and multidrug resistance phenotype in acute myelogenous leukemia before treatment and at relapse.
Leukemia, Myeloid, Acute
HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities.
Leukemia, Myeloid, Acute
Identification of a potential "hotspot" DNA region in the RUNX1 gene targeted by mitoxantrone in therapy-related acute myeloid leukemia with t(16;21) translocation.
Leukemia, Myeloid, Acute
Infant acute lymphoblastic leukemia with t(11;16)(q23;p13.3) and lineage switch into acute monoblastic leukemia.
Leukemia, Myeloid, Acute
Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action.
Leukemia, Myeloid, Acute
Inhibition of topoisomerase II in 32D.3(G) cells by hydroquinone is associated with cell death.
Leukemia, Myeloid, Acute
Inversion of chromosome 16 and uncommon rearrangements of the CBFB and MYH11 genes in therapy-related acute myeloid leukemia: rare events related to DNA-topoisomerase II inhibitors?
Leukemia, Myeloid, Acute
Is there an entity of chemically induced BCR-ABL-positive chronic myelogenous leukemia?
Leukemia, Myeloid, Acute
Loss of ISWI ATPase SMARCA5 (SNF2H) in Acute Myeloid Leukemia Cells Inhibits Proliferation and Chromatid Cohesion.
Leukemia, Myeloid, Acute
Lymphohematopoietic cancers induced by chemicals and other agents and their implications for risk evaluation: An overview.
Leukemia, Myeloid, Acute
Maternal diet and infant leukemia: a role for DNA topoisomerase II inhibitors?
Leukemia, Myeloid, Acute
Maternal diet and infant leukemia: the DNA topoisomerase II inhibitor hypothesis: a report from the children's oncology group.
Leukemia, Myeloid, Acute
Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): a report from the Children's Cancer Group.
Leukemia, Myeloid, Acute
Microhomologies and topoisomerase II consensus sequences identified near the breakpoint junctions of the recurrent t(7;21)(p22;q22) translocation in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Molecular emergence of acute myeloid leukemia during treatment for acute lymphoblastic leukemia.
Leukemia, Myeloid, Acute
MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25).
Leukemia, Myeloid, Acute
Multilocus association of genetic variants in MLL, CREBBP, EP300, and TOP2A with childhood acute lymphoblastic leukemia in Hispanics from Texas.
Leukemia, Myeloid, Acute
Multiple resistance mechanisms in acute nonlymphoblastic leukemia (ANLL).
Leukemia, Myeloid, Acute
New chemotherapeutic agents in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Nongenetic causes of childhood cancers: evidence from international variation, time trends, and risk factor studies.
Leukemia, Myeloid, Acute
Nucleotide-resolution mapping of topoisomerase-mediated and apoptotic DNA strand scissions at or near an MLL translocation hotspot.
Leukemia, Myeloid, Acute
Potential mechanisms of resistance to cytarabine in AML patients.
Leukemia, Myeloid, Acute
Potential role for DNA topoisomerase II poisons in the generation of t(11;20)(p15;q11) translocations.
Leukemia, Myeloid, Acute
Potential topoisomerase II DNA-binding sites at the breakpoints of a t(9;11) chromosome translocation in acute myeloid leukemia.
Leukemia, Myeloid, Acute
Predisposition to therapy-related acute leukemia with balanced chromosomal translocations does not result from a major constitutive defect in DNA double-strand break end joining.
Leukemia, Myeloid, Acute
Prognostic significance of beta-catenin and topoisomerase IIalpha in de novo acute myeloid leukemia.
Leukemia, Myeloid, Acute
Quantification of vosaroxin and its metabolites N-desmethylvosaroxin and O-desmethylvosaroxin in human plasma and urine using high-performance liquid chromatography-tandem mass spectrometry.
Leukemia, Myeloid, Acute
Rearrangement of the Myeloid/Lymphoid Leukemia Gene in Therapy-Related Myelodysplastic Syndrome in Patients Previously Treated with Agents Targeting DNA Topoisomerase II.
Leukemia, Myeloid, Acute
Rearrangements of the AML1/CBFA2 gene in myeloid leukemia with the 3;21 translocation: in vitro and in vivo studies.
Leukemia, Myeloid, Acute
Rearrangements of the MLL gene are influenced by DNA secondary structure, potentially mediated by topoisomerase II binding.
Leukemia, Myeloid, Acute
Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA-topoisomerase II.
Leukemia, Myeloid, Acute
Relationship between cytotoxicity and site-specific DNA recombination after in vitro exposure of leukemia cells to etoposide.
Leukemia, Myeloid, Acute
Resistance factors and proliferative activity in childhood acute nonlymphoblastic leukemia.
Leukemia, Myeloid, Acute
Secondary acute lymphoblastic leukemia with t (4;11): report on two cases and review of the literature.
Leukemia, Myeloid, Acute
Secondary acute myeloid leukemia in children previously treated with alkylating agents, intercalating topoisomerase II inhibitors, and irradiation.
Leukemia, Myeloid, Acute
T-cell acute lymphoblastic leukemia as a secondary leukemia after a 3-year remission of acute myelocytic leukemia.
Leukemia, Myeloid, Acute
Targeting RIOK2 ATPase activity leads to decreased protein synthesis and cell death in acute myeloid leukemia.
Leukemia, Myeloid, Acute
The clinical relevance of the expression of several multidrug-resistant-related genes in patients with primary acute myeloid leukemia.
Leukemia, Myeloid, Acute
The effect of 9-beta-D-arabinofuranosyl-2-fluoroadenine and 1-beta-D-arabinofuranosylcytosine on the cell cycle phase distribution, topoisomerase II level, mitoxantrone cytotoxicity, and DNA strand break production in K562 human leukemia cells.
Leukemia, Myeloid, Acute
The epidemiology of childhood leukemia with a focus on birth weight and diet.
Leukemia, Myeloid, Acute
Therapy-induced Deletion in 11q23 Leading to Fusion of KMT2A With ARHGEF12 and Development of B Lineage Acute Lymphoplastic Leukemia in a Child Treated for Acute Myeloid Leukemia Caused by t(9;11)(p21;q23)/KMT2A-MLLT3.
Leukemia, Myeloid, Acute
Therapy-related acute leukemia associated with involvement of 11q23 after high grade non-Hodgkin lymphoma.
Leukemia, Myeloid, Acute
Therapy-related acute myelogenous leukemia associated with 11q23 chromosomal abnormalities and topoisomerase II inhibitors: report of four additional cases and brief commentary.
Leukemia, Myeloid, Acute
Therapy-related acute myeloid leukemia following treatment with epipodophyllotoxins: estimating the risks.
Leukemia, Myeloid, Acute
Therapy-related acute myeloid leukemia secondary to inhibitors of topoisomerase II: from the bedside to the target genes.
Leukemia, Myeloid, Acute
Therapy-related acute myeloid leukemia with 11q23 abnormality due to paclitaxel coexisting with bone marrow metastasis of breast cancer.
Leukemia, Myeloid, Acute
Therapy-related acute myeloid leukemia with KMT2A-SNX9 gene fusion associated with a hyperdiploid karyotype after hemophagocytic lymphohistiocytosis.
Leukemia, Myeloid, Acute
Therapy-related acute myeloid leukemia-like MLL rearrangements are induced by etoposide in primary human CD34+ cells and remain stable after clonal expansion.
Leukemia, Myeloid, Acute
Therapy-related acute promyelocytic leukemia with t(15;17) (q22;q12) following chemotherapy with drugs targeting DNA topoisomerase II. A report of two cases and a review of the literature.
Leukemia, Myeloid, Acute
Therapy-related leukemia with Inv(16)(p13.1q22) and type D CBFB/MYH11 developing after exposure to irinotecan-containing chemoradiotherapy.
Leukemia, Myeloid, Acute
Topoisomerase II activities in AML and their correlation with cellular sensitivity to anthracyclines and epipodophyllotoxines.
Leukemia, Myeloid, Acute
Topoisomerase II activities in AML blasts and their correlation with cellular sensitivity to anthracyclines and epipodophyllotoxines.
Leukemia, Myeloid, Acute
Topoisomerase II levels and drug sensitivity in adult acute myelogenous leukemia.
Leukemia, Myeloid, Acute
Translocation (11;11)(p13- p15;q23) in a child with therapy-related acute myeloid leukemia following chemotherapy with DNA-topoisomerase II inhibitors for Langerhans cell histiocytosis.
Leukemia, Myeloid, Acute
Treatment-related myelodysplasia in patients with primary brain tumors.
Leukemia, Myeloid, Acute
Venetoclax Synergistically Enhances the Anti-leukemic Activity of Vosaroxin Against Acute Myeloid Leukemia Cells Ex Vivo.
Leukemia, Myeloid, Acute
[A case of therapy-related acute monocytic leukemia following low-dose of etoposide treatment for hemophagocytic lymphohistiocytosis]
Leukemia, Myeloid, Acute
[Chromosome translocations and leukemias induced by inhibitors of topoisomerase II anticarcinogenic drugs]
Leukemia, Myeloid, Acute
[Therapy-induced leukemia -- an underestimated complication of antineoplastic chemotherapy?]
Leukemia, Myeloid, Acute
[Therapy-Related Acute Myeloid Leukemia Following Etoposide Based Chemotherapy in Germ Cell Tumor].
Leukemia, Promyelocytic, Acute
Acute promyelocytic leukemia after treatment for non-Hodgkin's lymphoma with drugs targeting topoisomerase II.
Leukemia, Promyelocytic, Acute
Acute promyelocytic leukemia with t(15;17) following inhibition of DNA topoisomerase II.
Leukemia, Promyelocytic, Acute
Analysis of t(15;17) chromosomal breakpoint sequences in therapy-related versus de novo acute promyelocytic leukemia: association of DNA breaks with specific DNA motifs at PML and RARA loci.
Leukemia, Promyelocytic, Acute
Analysis of topoisomerase II-mediated DNA cleavage of the c-myc gene during HL60 differentiation.
Leukemia, Promyelocytic, Acute
Characterization of therapy-related acute leukemia in hereditary breast-ovarian carcinoma patients: role of BRCA1 mutation and topoisomerase II-directed therapy.
Leukemia, Promyelocytic, Acute
Chemotherapy-related acute promyelocytic leukemia: role of topoisomerase II.
Leukemia, Promyelocytic, Acute
Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia.
Leukemia, Promyelocytic, Acute
Cytotoxicity and cell cycle effects of novel indolo[2,3-b]quinoline derivatives.
Leukemia, Promyelocytic, Acute
DNA topoisomerase II in therapy-related acute promyelocytic leukemia.
Leukemia, Promyelocytic, Acute
Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia.
Leukemia, Promyelocytic, Acute
MLL/AF-1p fusion in therapy-related early pre-B acute lymphoblastic leukemia with t(1;11)(p32;q23) translocation developing in the relapse phase of acute promyelocytic leukemia.
Leukemia, Promyelocytic, Acute
Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis.
Leukemia, Promyelocytic, Acute
Secondary acute promyelocytic leukemia following chemotherapy for non-Hodgkin's lymphoma in a child.
Leukemia, Promyelocytic, Acute
The catalytic DNA topoisomerase II inhibitor ICRF-193 and all-trans retinoic acid cooperatively induce granulocytic differentiation of acute promyelocytic leukemia cells: candidate drugs for chemo-differentiation therapy against acute promyelocytic leukemia.
Leukemia, Promyelocytic, Acute
Therapy-related acute promyelocytic leukemia with t(15;17) (q22;q12) following chemotherapy with drugs targeting DNA topoisomerase II. A report of two cases and a review of the literature.
Leukemia, Promyelocytic, Acute
Translocation (3;21)(q26;q22) in treatment-related acute leukemia secondary to acute promyelocytic leukemia.
Leukemia, Promyelocytic, Acute
[Complication of topoisomerase II inhibitor-related acute promyelocytic leukemia with t(1;10) (q21;q26) in a patient with Sézary syndrome]
Leukemia, T-Cell
Biological evaluation of omega-(dialkylamino)alkyl derivatives of 6H-indolo[2,3-b]quinoline--novel cytotoxic DNA topoisomerase II inhibitors.
Leukemia, T-Cell
Cytochemical markers of murine leukemias and lymphomas.
Leukemia, T-Cell
Genetic characterization of the multidrug-resistant phenotype of VM-26-resistant human leukemic cells.
Leukemia, T-Cell
Possible roles of an adult T-cell leukemia (ATL)-derived factor/thioredoxin in the drug resistance of ATL to adriamycin.
Leukemia-Lymphoma, Adult T-Cell
Treatment of adult T-cell leukemia/lymphoma with MST-16, a new oral antitumor drug and a derivative of bis(2,6-dioxopiperazine). The MST-16 Study Group.
Li-Fraumeni Syndrome
p53 Regulates Hsp90 ATPase Activity and Thereby Wnt Signaling by Modulating Aha1 Expression.
Lichen Planus
Enzyme changes in lichen planus.
Lichen Planus, Oral
Assessment of langerhans cells in oral lichen planus by ATPase histochemistry: a clinicopathologic correlation.
Lichen Planus, Oral
Immunohistochemical study on topoisomerase IIalpha, Ki-67 and cytokeratin-19 in oral lichen planus lesions.
lipoprotein lipase deficiency
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Liposarcoma
Characteristics of genomic breakpoints in TLS-CHOP translocations in liposarcomas suggest the involvement of Translin and topoisomerase II in the process of translocation.
Liposarcoma
Clinicopathologic study of E-cadherin/beta-catenin complex, and topoisomerase-II in a series of 71 liposarcoma cases.
Liposarcoma
Expression profiling of liposarcoma yields a multigene predictor of patient outcome and identifies genes that contribute to liposarcomagenesis.
Liposarcoma
Small RNA sequencing and functional characterization reveals microRNA-143 tumor suppressor activity in liposarcoma.
Liposarcoma
Unique cell membrane expression of topoisomerase-II alpha as a useful diagnostic marker of liposarcoma.
Liposarcoma, Myxoid
Phase II study of amrubicin (SM-5887), a synthetic 9-aminoanthracycline, as first line treatment in patients with metastatic or unresectable soft tissue sarcoma: durable response in myxoid liposarcoma with TLS-CHOP translocation.
Listeriosis
Changes in cardiac and hepatic energetic metabolism in gerbils infected by Listeria monocytogenes.
Liver Abscess, Amebic
Obtaining of three recombinant antigens of Entamoeba histolytica and evaluation of their immunogenic ability without adjuvant in a hamster model of immunoprotection.
Liver Cirrhosis
MicroRNA29a Reverts the Activated Hepatic Stellate Cells in the Regression of Hepatic Fibrosis through Regulation of ATPase H? Transporting V1 Subunit C1.
Liver Cirrhosis
The expression of transforming growth factor-alpha in cirrhosis, dysplastic nodules, and hepatocellular carcinoma: an immunohistochemical study of 70 cases.
Liver Cirrhosis
[Comparative characteristics of adenosine triphosphatase activity in the erythrocytes of patients with acute and chronic liver diseases, chronic cholecystitis and in HBs antigen carriers]
Liver Cirrhosis
[Differential, diagnostic value of determination of total ATPase in the erythrocytes in acute and chronic viral hepatitis, liver cirrhosis and obstructive jaundice]
Liver Cirrhosis, Biliary
Antimitochondrial antibodies (AMA) in primary biliary cirrhosis. I. Separation of the PBC antigen activity from mitochondrial ATPase activity.
Liver Cirrhosis, Biliary
Correlation of oligomycin-sensitive ATPase activity in trypanosomes with their content of an antigen to primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Distribution of the PBC-specific- (M2) and the naturally-occurring mitochondrial antigen- (NOMAg) systems in plants.
Liver Cirrhosis, Biliary
Mitochondrial antibodies in primary biliary cirrhosis. VI. Association of the complement fixing antigen with a component of the mitochondrial F1-ATPase complex.
Liver Cirrhosis, Biliary
Mitochondrial antibodies in primary biliary cirrhosis: species and nonspecies specific determinants of M2 antigen.
Liver Cirrhosis, Experimental
Alterations in the physicochemical properties of renal cortical membranes in rats with experimental cirrhosis of the liver.
Liver Diseases
Effects of ethanol and acetaldehyde on hepatic plasma membrane ATPases.
Liver Diseases
Functional and topological properties in hepatocellular carcinoma transcriptome.
Liver Diseases
Mitochondrial antibodies in chronic liver diseases and connective tissue disorders: further characterization of the autoantigens.
Liver Diseases
[Comparative characteristics of adenosine triphosphatase activity in the erythrocytes of patients with acute and chronic liver diseases, chronic cholecystitis and in HBs antigen carriers]
Liver Diseases, Alcoholic
Effects of ethanol and acetaldehyde on hepatic plasma membrane ATPases.
Liver Diseases, Alcoholic
Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function.
Liver Failure
Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4 ATPases.
Liver Failure, Acute
Inhibition of partially purified rat brain Na+, K+-dependent ATPase by bile acids, phenolic acids and endotoxin.
Liver Failure, Acute
Mutation of mitochondrial ATP8 gene improves hepatic energy status in a murine model of acute endotoxemic liver failure.
Liver Neoplasms
A homeopathic nosode, Hepatitis C 30 demonstrates anticancer effect against liver cancer cells in vitro by modulating telomerase and topoisomerase II activities as also by promoting apoptosis via intrinsic mitochondrial pathway.
Liver Neoplasms
Autoantibody to DNA topoisomerase II in primary liver cancer
Liver Neoplasms
Clinical characterization for proliferation and metastasis in advanced hepatocellular carcinoma patients.
Liver Neoplasms
Comparative in vitro bioactivities of tea extracts from six species of Ardisia and their effect on growth inhibition of HepG2 cells.
Liver Neoplasms
Computational analysis for identification of early diagnostic biomarkers and prognostic biomarkers of liver cancer based on GEO and TCGA databases and studies on pathways and biological functions affecting the survival time of liver cancer.
Liver Neoplasms
Expression of c-myc in altered hepatic foci induced in rats by various single doses of diethylnitrosamine and promotion by 0.05% phenobarbital.
Liver Neoplasms
Flavonoid-enriched apple fraction AF4 induces cell cycle arrest, DNA topoisomerase II inhibition, and apoptosis in human liver cancer HepG2 cells.
Liver Neoplasms
High expression of TOP2A in hepatocellular carcinoma is associated with disease progression and poor prognosis.
Liver Neoplasms
Identifying Key Genes of Liver Cancer by Networking of Multiple Data Sets.
Liver Neoplasms
Multiple roles for PARP1 in ALC1-dependent nucleosome remodeling.
Liver Neoplasms
Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler.
Liver Neoplasms
Screening and function analysis of hub genes and pathways in hepatocellular carcinoma via bioinformatics approaches.
Liver Neoplasms
Sorafenib-mediated targeting of the AAA? ATPase p97/VCP leads to disruption of the secretory pathway, endoplasmic reticulum stress, and hepatocellular cancer cell death.
Liver Neoplasms
[Role of DNA topoisomerase II alpha in intrinsic and acquired drug resistance of liver cancer.]
Liver Neoplasms, Experimental
Deoxyribonucleic acid dependent adenosinetriphosphatases from the Novikoff hepatoma. Characterization of a homogeneous adenosinetriphosphatase that stimulates DNA polymerase beta.
Liver Neoplasms, Experimental
Kinetic properties of mitochondrial H+-adenosine triphosphatase in Morris hepatoma 3924A.
Liver Neoplasms, Experimental
Purification and enzymological characterization of DNA-dependent ATPase IV from the Novikoff hepatoma.
Lung Diseases
First-in-Human Evaluation of the Safety, Tolerability, and Pharmacokinetics of SPR720, a Novel Oral Bacterial DNA Gyrase (GyrB) Inhibitor for Mycobacterial Infections.
Lung Injury
Endogenous Na/K ATPase inhibitor ouabain in critically ill children with lung injury.
Lung Injury
[Effects of normal lymph on myeloperoxidase activity and adenosine triphosphatase in rats with endotoxic shock]
Lung Injury
[Observation on both Na(+)-K+ Atpase activity and expression of Na(+)-K+ AtPase alpha1 mRNA in lung tissues of rats acute poisoned with nickel carbonyl].
Lung Neoplasms
17-(Allylamino)-17-Demethoxygeldanamycin Enhances Etoposide-Induced Cytotoxicity via the Downregulation of Xeroderma Pigmentosum Complementation Group C Expression in Human Lung Squamous Cell Carcinoma Cells.
Lung Neoplasms
A dual mechanism of action of the anticancer agent F 11782 on human topoisomerase II alpha.
Lung Neoplasms
A phase I study of irinotecan in combination with amrubicin for advanced lung cancer patients.
Lung Neoplasms
A phase I study of sequential intravenous topotecan and etoposide in lung cancer patients.
Lung Neoplasms
A single-arm confirmatory study of amrubicin therapy in patients with refractory small-cell lung cancer: Japan Clinical Oncology Group Study (JCOG0901).
Lung Neoplasms
A truncated cytoplasmic topoisomerase IIalpha in a drug-resistant lung cancer cell line is encoded by a TOP2A allele with a partial deletion of exon 34.
Lung Neoplasms
Altered subcellular distribution of topoisomerase II alpha in a drug-resistant human small cell lung cancer cell line.
Lung Neoplasms
Altered topoisomerase II alpha in a drug-resistant small cell lung cancer cell line selected in VP-16.
Lung Neoplasms
Alternative polyadenylation is associated with lower expression of PABPN1 and poor prognosis in non-small cell lung cancer.
Lung Neoplasms
Amplification of the topoisomerase II alpha gene in a non-small cell lung cancer cell line and characterisation of polymorphisms at the human topoisomerase II alpha and beta loci in normal tissue.
Lung Neoplasms
Antagonistic effect of aclarubicin on daunorubicin-induced cytotoxicity in human small cell lung cancer cells: relationship to DNA integrity and topoisomerase II.
Lung Neoplasms
Association of Topoisomerase II (TOP2A) and Dual-Specificity Phosphatase 6 (DUSP6) Single Nucleotide Polymorphisms with Radiation Treatment Response and Prognosis of Lung Cancer in Han Chinese.
Lung Neoplasms
ATPase inhibitory factor 1 expression is an independent prognostic factor in non-small cell lung cancer.
Lung Neoplasms
B1, a novel HDAC inhibitor, induces apoptosis through the regulation of STAT3 and NF-?B.
Lung Neoplasms
BRG1/SMARCA4 inactivation promotes non-small cell lung cancer aggressiveness by altering chromatin organization.
Lung Neoplasms
Cell proliferation and apoptosis in stage III inoperable non-small cell lung carcinoma treated by radiotherapy.
Lung Neoplasms
Characterization of a topoisomerase II gene rearrangement in a human small-cell lung cancer cell line.
Lung Neoplasms
Chemopreventive effect of piperine on modulating lipid peroxidation and membrane bound enzymes in benzo(a)pyrene induced lung carcinogenesis.
Lung Neoplasms
Clinical significance of topoisomerase-II expression in patients with advanced non-small cell lung cancer treated with amrubicin.
Lung Neoplasms
Combination of irinotecan and etoposide for treatment of refractory or relapsed small-cell lung cancer.
Lung Neoplasms
Comparison of DNA cleavage induced by etoposide and doxorubicin in two human small-cell lung cancer lines with different sensitivities to topoisomerase II inhibitors.
Lung Neoplasms
Cytoplasmic localization of a mutant M(r) 160,000 topoisomerase II alpha is associated with the loss of putative bipartite nuclear localization signals in a drug-resistant human lung cancer cell line.
Lung Neoplasms
Determinants of response to the DNA topoisomerase II inhibitors doxorubicin and etoposide in human lung cancer cell lines.
Lung Neoplasms
Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cells.
Lung Neoplasms
Differential expression of DNA topoisomerase II alpha and II beta genes between small cell and non-small cell lung cancer.
Lung Neoplasms
Differential expression of DNA topoisomerases in non-small cell lung cancer and normal lung.
Lung Neoplasms
Differential sensitivity patterns in small cell lung cancer cell lines: detection and circumvention of resistance to topoisomerase II targeting drugs.
Lung Neoplasms
E-M, an Engineered Endostatin with High ATPase Activity, Inhibits the Recruitment and Alternative Activation of Macrophages in Non-small Cell Lung Cancer.
Lung Neoplasms
Effect of TOP2A and ERCC1 gene polymorphisms on the efficacy and toxicity of cisplatin and etoposide-based chemotherapy in small cell lung cancer patients.
Lung Neoplasms
Effects of N-terminus modified Hx-amides on DNA binding affinity, sequence specificity, cellular uptake, and gene expression.
Lung Neoplasms
Efficacy of substituted 9-aminoacridine derivatives in small cell lung cancer.
Lung Neoplasms
Etoposide-induced cell cycle delay and arrest-dependent modulation of DNA topoisomerase II in small-cell lung cancer cells.
Lung Neoplasms
Excision repair cross complementing-1 and topoisomerase IIalpha gene expression in small-cell lung cancer patients treated with platinum and etoposide: a retrospective study.
Lung Neoplasms
Expression analysis of multidrug resistance associated genes in neuroblastomas.
Lung Neoplasms
Expression of DNA topoisomerase IIalpha and topoisomerase IIbeta genes predicts survival and response to chemotherapy in patients with small cell lung cancer.
Lung Neoplasms
Expression of resistance-related proteins in tumoral and peritumoral tissues of patients with lung cancer.
Lung Neoplasms
Expression of topoisomerase II alpha and beta in an adenocarcinoma cell line carrying amplified topoisomerase II alpha and retinoic acid receptor alpha genes.
Lung Neoplasms
Expression of Y box-binding protein-1 correlates with DNA topoisomerase IIalpha and proliferating cell nuclear antigen expression in lung cancer.
Lung Neoplasms
EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors.
Lung Neoplasms
Formulation and pharmacokinetic evaluation of an asulacrine nanocrystalline suspension for intravenous delivery.
Lung Neoplasms
Fractionated irradiation of H69 small-cell lung cancer cells causes stable radiation and drug resistance with increased MRP1, MRP2, and topoisomerase IIalpha expression.
Lung Neoplasms
Frequent BRG1/SMARCA4-inactivating mutations in human lung cancer cell lines.
Lung Neoplasms
Gene-specific damage produced by topoisomerase inhibitors in human lung cancer cells and peripheral mononuclear cells as assayed by polymerase chain reaction-stop assay.
Lung Neoplasms
Growth inhibitory effects of antifolates against an adriamycin-resistant human small cell lung cancer cell line.
Lung Neoplasms
High expression of topoisomerase-II predicts favorable clinical outcomes in patients with relapsed small cell lung cancers receiving amrubicin.
Lung Neoplasms
Higher expression of topoisomerase II in lung cancers than normal lung tissues: different expression pattern from topoisomerase I.
Lung Neoplasms
Human small cell lung cancer NYH cells resistant to the bisdioxopiperazine ICRF-187 exhibit a functional dominant Tyr165Ser mutation in the Walker A ATP binding site of topoisomerase II alpha.
Lung Neoplasms
Human small cell lung cancer NYH cells selected for resistance to the bisdioxopiperazine topoisomerase II catalytic inhibitor ICRF-187 demonstrate a functional R162Q mutation in the Walker A consensus ATP binding domain of the alpha isoform.
Lung Neoplasms
ICRF-187 rescue in etoposide treatment in vivo. A model targeting high-dose topoisomerase II poisons to CNS tumors.
Lung Neoplasms
Identification of decatenation G2 checkpoint impairment independently of DNA damage G2 checkpoint in human lung cancer cell lines.
Lung Neoplasms
Identification of differentially expressed genes in non-small cell lung cancer.
Lung Neoplasms
Identification of tumor-associated antigens of lung cancer: SEREX combined with bioinformatics analysis.
Lung Neoplasms
Immunohistochemical detection of DNA topoisomerase IIalpha, P-glycoprotein and multidrug resistance protein (MRP) in small-cell and non-small-cell lung cancer.
Lung Neoplasms
In vitro schedule dependency in the treatment of topoisomerase I and II inhibitor.
Lung Neoplasms
Loss of amino acids 1490Lys-Ser-Lys1492 in the COOH-terminal region of topoisomerase IIalpha in human small cell lung cancer cells selected for resistance to etoposide results in an extranuclear enzyme localization.
Lung Neoplasms
Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis.
Lung Neoplasms
Loss of the SWI/SNF ATPase subunits BRM and BRG1 drives lung cancer development.
Lung Neoplasms
Massive parallel DNA pyrosequencing analysis of the tumor suppressor BRG1/SMARCA4 in lung primary tumors.
Lung Neoplasms
Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase.
Lung Neoplasms
Mitoxantrone-DNA binding and the induction of topoisomerase II associated DNA damage in multi-drug resistant small cell lung cancer cells.
Lung Neoplasms
Multidrug resistance protein and topoisomerase 2 alpha expression in non-small cell lung cancer are related with brain metastasis postoperatively.
Lung Neoplasms
Multidrug resistance related genes and p53 expression in human non small cell lung cancer.
Lung Neoplasms
Multidrug sensitivity phenotype of human lung cancer cells associated with topoisomerase II expression.
Lung Neoplasms
Mutation frequency and spectrum in lymphocytes of small cell lung cancer patients receiving etoposide chemotherapy.
Lung Neoplasms
Na+/K+ ATPase inhibitors in cancer.
Lung Neoplasms
Na+/K+-ATPase Revisited: On Its Mechanism of Action, Role in Cancer, and Activity Modulation.
Lung Neoplasms
Non-P-glycoprotein-mediated multidrug resistance in a small cell lung cancer cell line: evidence for decreased susceptibility to drug-induced DNA damage and reduced levels of topoisomerase II.
Lung Neoplasms
Novel indolizino[8,7-b]indole hybrids as anti-small cell lung cancer agents: Regioselective modulation of topoisomerase II inhibitory and DNA crosslinking activities.
Lung Neoplasms
P21 response to DNA damage induced by genistein and etoposide in human lung cancer cells.
Lung Neoplasms
Participation of poly(ADP-ribose) polymerase in the drug sensitivity in human lung cancer cell lines.
Lung Neoplasms
Pericentromeric Satellite III transcripts induce etoposide resistance.
Lung Neoplasms
Phase I study of sequentially administered topoisomerase I inhibitor (irinotecan) and topoisomerase II inhibitor (etoposide) for metastatic non-small-cell lung cancer.
Lung Neoplasms
Phase II multicenter trial of voreloxin as second-line therapy in chemotherapy-sensitive or refractory small cell lung cancer.
Lung Neoplasms
Phase II study of dose-intense chemotherapy with sequential topoisomerase-targeting regimens with irinotecan/oxaliplatin followed by etoposide/carboplatin in chemotherapy naive patients with extensive small cell lung cancer.
Lung Neoplasms
Phase II trial of amrubicin for treatment of refractory or relapsed small-cell lung cancer: Thoracic Oncology Research Group Study 0301.
Lung Neoplasms
Phase IV trial of daily oral etoposide in the treatment of advanced soft-tissue sarcoma.
Lung Neoplasms
Point mutations of the topoisomerase IIalpha gene in patients with small cell lung cancer treated with etoposide.
Lung Neoplasms
Probable etoposide interaction with Echinacea.
Lung Neoplasms
Prognostic significance of ERCC1, RRM1, TOP1, TOP2A, TYMS, TUBB3, GSTP1 AND BRCA1 mRNA expressions in patients with non-small-cell lung cancer receiving a platinum-based chemotherapy.
Lung Neoplasms
Prognostic significance of TOP2A in non-small cell lung cancer revealed by bioinformatic analysis.
Lung Neoplasms
Promoter polymorphisms of TOP2A and ERCC1 genes as predictive factors for chemotherapy in non-small cell lung cancer patients.
Lung Neoplasms
QS-ZYX-1-61 induces apoptosis through topoisomerase II in human non-small-cell lung cancer A549 cells.
Lung Neoplasms
Quantitation of DNA topoisomerase II alpha messenger ribonucleic acid levels in a small cell lung cancer cell line and two drug resistant sublines using a polymerase chain reaction-aided transcript titration assay.
Lung Neoplasms
Quantitative immunocytochemical assays of topoisomerase II in lung adenocarcinoma cell lines. Correlation to topoisomerase II alpha content and topoisomerase II catalytic activity.
Lung Neoplasms
Radiation enhancement by the combined use of topoisomerase I inhibitors, RFS-2000 or CPT-11, and topoisomerase II inhibitor etoposide in human lung cancer cells.
Lung Neoplasms
Randomized phase III trial of amrubicin versus topotecan as second-line treatment for patients with small-cell lung cancer.
Lung Neoplasms
Randomized phase III trial of paclitaxel, etoposide, and carboplatin versus carboplatin, etoposide, and vincristine in patients with small-cell lung cancer.
Lung Neoplasms
Reduced expression of DNA topoisomerase II confers resistance to etoposide (VP-16) in small cell lung cancer cell lines established from a refractory tumor of a patient and by in vitro selection.
Lung Neoplasms
Reduced topoisomerase II activity in multidrug-resistant human non-small cell lung cancer cell lines.
Lung Neoplasms
Relationship between topoisomerase II levels and resistance to topoisomerase II inhibitors in lung cancer cell lines.
Lung Neoplasms
Relationship of mRNA expressions of RanBP2 and topoisomerase II isoforms to cytotoxicity of amrubicin in human lung cancer cell lines.
Lung Neoplasms
Resveratrol Enhances Etoposide-Induced Cytotoxicity through Down-Regulating ERK1/2 and AKT-Mediated X-ray Repair Cross-Complement Group 1 (XRCC1) Protein Expression in Human Non-Small-Cell Lung Cancer Cells.
Lung Neoplasms
Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells.
Lung Neoplasms
RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer.
Lung Neoplasms
Sensitivity to TOP2 Targeting Chemotherapeutics Is Regulated by Oct1 and FILIP1L.
Lung Neoplasms
Simultaneous quantitation of topoisomerase II alpha and beta isoform mRNAs in lung tumor cells and normal and malignant lung tissue.
Lung Neoplasms
Solamargine enhances HER2 expression and increases the susceptibility of human lung cancer H661 and H69 cells to trastuzumab and epirubicin.
Lung Neoplasms
Stabilization of membrane bound enzyme profiles and lipid peroxidation by Withania somnifera along with paclitaxel on benzo(a)pyrene induced experimental lung cancer.
Lung Neoplasms
Suramin inhibits the phosphorylation and catalytic activity of DNA topoisomerase II in human lung cancer cells.
Lung Neoplasms
The analysis of chemotherapy resistance in human lung cancer cell line with microchip-based system.
Lung Neoplasms
The expression of V-ATPase is associated with drug resistance and pathology of non-small-cell lung cancer.
Lung Neoplasms
The reversible epigenetic silencing of BRM: implications for clinical targeted therapy.
Lung Neoplasms
The significance of the sequence of administration of topotecan and etoposide.
Lung Neoplasms
The steroidal Na+/K+ ATPase inhibitor 3-[(R)-3-pyrrolidinyl]oxime derivative (3-R-POD) induces potent pro-apoptotic responses in colonic tumor cells.
Lung Neoplasms
Tirapazamine: a hypoxia-activated topoisomerase II poison.
Lung Neoplasms
TOP2A Promotes Lung Adenocarcinoma Cells' Malignant Progression and Predicts Poor Prognosis in Lung Adenocarcinoma.
Lung Neoplasms
Topoisomerase I and II activity in human breast, cervix, lung and colon cancer.
Lung Neoplasms
Topoisomerase II alpha content and topoisomerase II catalytic activity cannot explain drug sensitivities to topoisomerase II inhibitors in lung cancer cell lines.
Lung Neoplasms
Topoisomerase II alpha expression and the benefit of adjuvant chemotherapy for postoperative patients with non-small cell lung cancer.
Lung Neoplasms
Topoisomerase II alpha gene expression in childhood acute lymphoblastic leukemia.
Lung Neoplasms
Topoisomerase II levels and drug response in small cell lung cancer.
Lung Neoplasms
Topoisomerase IIalpha and other drug resistance markers in advanced non-small cell lung cancer.
Lung Neoplasms
Two COOH-terminal truncated cytoplasmic forms of topoisomerase II alpha in a VP-16-selected lung cancer cell line result from partial gene deletion and alternative splicing.
Lung Neoplasms
Two schedules of teniposide with or without cisplatin in advanced non-small-cell lung cancer: a randomized study of the European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group.
Lung Neoplasms
Tyrosine kinase inhibitors potentiate the cytotoxicity of MDR-substrate anticancer agents independent of growth factor receptor status in lung cancer cell lines.
Lung Neoplasms
Vacuolar protein sorting 4B regulates apoptosis of intestinal epithelial cells via p38 MAPK in Crohn's disease.
Lung Neoplasms
Validation of a polymerase chain reaction aided transcript titration assay (PATTY) for topoisomerase II in lung cancer samples.
Lung Neoplasms
[Cytotoxic effect of topoisomerase II inhibitors against adriamycin- and etoposide-resistant small cell lung cancer sublines]
Lung Neoplasms
[Effect of electron-acceptor compounds on the immunoregulatory mechanisms and ATPase activity of the erythrocyte membranes from patients with inoperable lung cancer]
Lung Neoplasms
[Expression of multiple drug resistance-associated proteins in non-small cell lung cancer tissues and its clinical significance.]
Lung Neoplasms
[Overexpression and its clinical significance of multi-drug resistance associated genes in lung cancer tissues.]
Lung Neoplasms
[Relationship between expression of apoptosis-related genes and multidrug resistance genes in lung cancer tissues and their clinical significance.]
Lung Neoplasms
[Substantiation of Expressive Markers Use to Personalize Lung Cancer Chemotherapy].
Lung Neoplasms
[Therapy-related acute non-lymphocytic leukemia (M2) with 7;11 chromosome translocation induced into complete remission by low dose cytosine arabinoside and cytarabine ocfosfate therapy]
Lupus Erythematosus, Systemic
Formation of different abzymes in autoimmune-prone MRL-lpr/lpr mice is associated with changes in colony formation of haematopoietic progenitors.
Lupus Erythematosus, Systemic
Human autoantibody to topoisomerase II.
Lupus Erythematosus, Systemic
Increased 8-hydroxy-2'-deoxyguanosine in plasma and decreased mRNA expression of human 8-oxoguanine DNA glycosylase 1, anti-oxidant enzymes, mitochondrial biogenesis-related proteins and glycolytic enzymes in leucocytes in patients with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Systemic lupus erythematosus presenting initially as hydrogen ATPase pump defects of distal renal tubular acidosis.
Lupus Nephritis
Expression of DNA topoisomerases in chronic proliferative kidney disease.
Lymphatic Metastasis
ATAD2 overexpression is associated with progression and prognosis in colorectal cancer.
Lymphatic Metastasis
Correlations of ICAM-1 gene polymorphisms with susceptibility and multidrug resistance in colorectal cancer in a Chinese population.
Lymphatic Metastasis
Extensive analysis of the molecular biomarkers excision repair cross complementing 1, ribonucleotide reductase M1, ?-tubulin III, thymidylate synthetase, and topoisomerase II? in breast cancer: Association with clinicopathological characteristics.
Lymphatic Metastasis
Joint detection of multiple immunohistochemical indices and clinical significance in breast cancer.
Lymphatic Metastasis
P-Gp and TOPO II Expression and Their Clinical Significance in Colon Cancer.
Lymphatic Metastasis
Plasma membrane calcium ATPase expression in human colon multistep carcinogenesis.
Lymphatic Metastasis
Prognostic value of Topoisomerase II in female breast cancer.
Lymphatic Metastasis
Topoisomerase II alpha expression in breast ductal invasive carcinomas and correlation with clinicopathological variables.
Lymphatic Metastasis
Topoisomerase II alpha expression in esophageal squamous cell carcinoma.
Lymphatic Metastasis
Topoisomerase IIalpha expression in breast cancer: correlation with outcome variables.
Lymphatic Metastasis
[Correlation between aneuploidy of chromosome 17, over-expression of TP53 and TOPIIalpha, and the clinicopathological features and diagnosis of gastric adenocarcinoma]
Lymphatic Metastasis
[Expression of glutathione S-transferase-pi and DNA topoisomerase II alpha and their implications in colorectal carcinoma]
Lymphatic Metastasis
[Expression of topoisomerase II alpha in human colorectal carcinoma and its significance.]
Lymphocytic Choriomeningitis
Correction: Interactome analysis of the lymphocytic choriomeningitis virus nucleoprotein in infected cells reveals ATPase Na+/K+ transporting subunit Alpha 1 and prohibitin as host-cell factors involved in the life cycle of mammarenaviruses.
Lymphocytic Choriomeningitis
Interactome analysis of the lymphocytic choriomeningitis virus nucleoprotein in infected cells reveals ATPase Na+/K+ transporting subunit Alpha 1 and prohibitin as host-cell factors involved in the life cycle of mammarenaviruses.
Lymphohistiocytosis, Hemophagocytic
[A case of therapy-related acute monocytic leukemia following low-dose of etoposide treatment for hemophagocytic lymphohistiocytosis]
Lymphoma
A case of therapy-related acute myeloblastic leukemia with t(16;21)(q24;q22) after chemotherapy with DNA-topoisomerase II inhibitors, etoposide and mitoxantrone, and the alkylating agent, cyclophosphamide.
Lymphoma
A New Class of ?-Pyrrolidino-1,2,3-Triazole Derivatives as ?-Adrenergic Receptor Inhibitors: Synthesis, Pharmacological, and Docking Studies.
Lymphoma
A novel quantitative PCR of proliferation markers (Ki-67, topoisomerase IIalpha, and TPX2): an immunohistochemical correlation, testing, and optimizing for mantle cell lymphoma.
Lymphoma
Acute leukemia presenting a variant Ph chromosome with p190 expression, dup 3q and -7, developed after malignant lymphoma treated with alkylating agents and topoisomerase II inhibitors.
Lymphoma
BAF complexes facilitate decatenation of DNA by topoisomerase II?.
Lymphoma
c-Fos degradation by the proteasome. An early, Bcl-2-regulated step in apoptosis.
Lymphoma
Characterization of the genotoxicity of anthraquinones in mammalian cells.
Lymphoma
Clinical feasibility of oral low-dose etoposide and sobuzoxane for conventional chemotherapy-intolerant lymphoma patients.
Lymphoma
Correspondence re: M. Provencio, et al. the topoisomerase IIa expression correlates with survival in patients with advanced Hodgkin's lymphoma. Clin. Cancer Res., 9: 1406-1411, 2003.
Lymphoma
Cytochemical markers of murine leukemias and lymphomas.
Lymphoma
Different types of combination effects for the induction of micronuclei in mouse lymphoma cells by binary mixtures of the genotoxic agents MMS, MNU, and genistein.
Lymphoma
Differential immunohistochemical staining for DNA topoisomerase II alpha and beta in human tissues and for DNA topoisomerase II beta in non-Hodgkin's lymphomas.
Lymphoma
Dose escalation study to evaluate safety, tolerability and efficacy of intravenous etoposide phosphate administration in 27 dogs with multicentric lymphoma.
Lymphoma
Effects of adenoviral wild-type p53 gene transfer in p53-mutated lymphoma cells.
Lymphoma
Etoposide, cadmium chloride, benzo[a]pyrene, cyclophosphamide and colchicine tested in the in vitro mammalian cell micronucleus test (MNvit) in the presence and absence of cytokinesis block using L5178Y mouse lymphoma cells and 2-aminoanthracene tested in MNvit in the absence of cytokinesis block using TK6 cells at AstraZeneca UK, in support of OECD draft Test Guideline 487.
Lymphoma
Evaluation of DNA topoisomerase IIalpha expression provides independent prognostic information in non-Hodgkin's lymphomas.
Lymphoma
Evaluation of the MDR1, ABCG2, Topoisomerases IIalpha and GSTpi gene expression in patients affected by aggressive mantle cell lymphoma treated by the R-Hyper-CVAD regimen.
Lymphoma
Feasibility of salvage chemotherapy for refractory or relapsed non-Hodgkin's lymphoma with two topoisomerase II inhibitors, MST-16 and VP-16. MST-16 Study Group.
Lymphoma
Genotoxicity of inhibitors of DNA topoisomerases I (camptothecin) and II (m-AMSA) in vivo and in vitro.
Lymphoma
Genotoxicity of several clinically used topoisomerase II inhibitors.
Lymphoma
Germline variations of the topoisomerase IIalpha gene as risk factors for primary gastric B-cell lymphoma.
Lymphoma
Histological type distribution and expression of nm23, VEGF, TOP2A and MUM-1 in peripheral T-cell and NK-cell lymphomas in Chinese: analysis of 313 cases.
Lymphoma
Human 170 kDa and 180 kDa topoisomerases II bind preferentially to curved and left-handed linear DNA.
Lymphoma
Immunohistochemical staining for DNA topoisomerase II in non-Hodgkin's lymphomas.
Lymphoma
Investigations into the concept of a threshold for topoisomerase inhibitor-induced clastogenicity.
Lymphoma
Long-term administration of oral low-dose topoisomerase II inhibitors, MST-16 and VP-16, for refractory or relapsed non-Hodgkin's lymphoma.
Lymphoma
Loss of drug-stimulated topoisomerase II DNA breaks in living cells is different at two unrelated loci.
Lymphoma
Mg2+-dependent adenosine triphosphatase as an enzyme histochemical marker for the lymphomas of B-cell origin.
Lymphoma
Modulation of drug-induced apoptosis in a human B-lymphoma cell line (HT58).
Lymphoma
Mutation frequency and spectrum in lymphocytes of small cell lung cancer patients receiving etoposide chemotherapy.
Lymphoma
Rearrangements of the MLL gene are influenced by DNA secondary structure, potentially mediated by topoisomerase II binding.
Lymphoma
Relationship between topoisomerase II and radiosensitivity in mouse L5178Y lymphoma strains.
Lymphoma
Sensitivity to inhibitors of type II topoisomerases from mouse L5178Y lymphoma strains that are resistant or sensitive to X-radiation.
Lymphoma
Sensitivity to TOP2 Targeting Chemotherapeutics Is Regulated by Oct1 and FILIP1L.
Lymphoma
Synthesis of new class of spirocarbocycle derivatives by multicomponent domino reaction and their evaluation for antimicrobial, anticancer activity and molecular docking studies.
Lymphoma
The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning.
Lymphoma
The redistribution of membrane surface immunoglobulin induces the rearrangement of some membrane integral proteins.
Lymphoma
The structure and function of NKAIN2-a candidate tumor suppressor.
Lymphoma
The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-?B Signaling via Partial Degradation of the NF-?B Subunit p100.
Lymphoma
Topoisomerase II alpha mRNA and tumour cell proliferation in non-Hodgkin's lymphoma.
Lymphoma
Topoisomerase II inhibition involves characteristic chromosomal expression patterns.
Lymphoma
Topoisomerase II inhibitor-induced apoptosis in thymocytes and lymphoma cells.
Lymphoma
Topoisomerase IIalpha as a prognostic factor in mantle cell lymphoma.
Lymphoma
Topoisomerase IIalpha expression in mantle cell lymphoma: a marker of cell proliferation and a prognostic factor for clinical outcome.
Lymphoma
[HCO3-sensitive adenosinetriphosphatase from ascites tumour cells]
Lymphoma
[Immunohistochemical evaluation of topoisomerase IIalpha as proliferation factor in gastric lymphoma]
Lymphoma
[Oral antitumor drugs for hematological malignancies]
Lymphoma
[The expression of ki-67, topoIIalpha in laryngeal squamous cell carcinoma]
Lymphoma, B-Cell
Enzyme histochemistry of non-Hodgkin's lymphomas.
Lymphoma, B-Cell
Germline variations of the topoisomerase IIalpha gene as risk factors for primary gastric B-cell lymphoma.
Lymphoma, B-Cell
High expression of Bcl-2 predicts poor outcome in diffuse large B-cell lymphoma patients with low international prognostic index receiving R-CHOP chemotherapy.
Lymphoma, B-Cell
High levels of topoisomerase IIalpha protein expression in diffuse large B-cell lymphoma are associated with high proliferation, germinal center immunophenotype, and response to treatment.
Lymphoma, B-Cell
Identification of collaborative activities with oxidative phosphorylation in bipolar disorder.
Lymphoma, B-Cell
Lack of topoisomerase copy number changes in patients with de novo and relapsed diffuse large B-cell lymphoma.
Lymphoma, B-Cell
Molecular docking and dynamics simulation study of bioactive compounds from Ficus carica L. with important anticancer drug targets.
Lymphoma, B-Cell
p38 MAP kinase plays a role in G2 checkpoint activation and inhibits apoptosis of human B cell lymphoma cells treated with etoposide.
Lymphoma, B-Cell
Regulation of p38 phosphorylation and topoisomerase IIalpha expression in the B-cell lymphoma line Jiyoye by CD26/dipeptidyl peptidase IV is associated with enhanced in vitro and in vivo sensitivity to doxorubicin.
Lymphoma, Follicular
Enzyme histochemistry of non-Hodgkin's lymphomas.
Lymphoma, Follicular
Mg2+-dependent adenosine triphosphatase as an enzyme histochemical marker for the lymphomas of B-cell origin.
Lymphoma, Large B-Cell, Diffuse
High expression of Bcl-2 predicts poor outcome in diffuse large B-cell lymphoma patients with low international prognostic index receiving R-CHOP chemotherapy.
Lymphoma, Large B-Cell, Diffuse
High levels of topoisomerase IIalpha protein expression in diffuse large B-cell lymphoma are associated with high proliferation, germinal center immunophenotype, and response to treatment.
Lymphoma, Large B-Cell, Diffuse
Inhibition of human topoisomerase II by anti-neoplastic benzazolo[3,2-alpha]quinolinium chlorides.
Lymphoma, Large B-Cell, Diffuse
Lack of topoisomerase copy number changes in patients with de novo and relapsed diffuse large B-cell lymphoma.
Lymphoma, Large B-Cell, Diffuse
Topoisomerase II beta levels are a determinant of melphalan-induced DNA crosslinks and sensitivity to cell death.
Lymphoma, Mantle-Cell
A novel quantitative PCR of proliferation markers (Ki-67, topoisomerase IIalpha, and TPX2): an immunohistochemical correlation, testing, and optimizing for mantle cell lymphoma.
Lymphoma, Mantle-Cell
Evaluation of the MDR1, ABCG2, Topoisomerases IIalpha and GSTpi gene expression in patients affected by aggressive mantle cell lymphoma treated by the R-Hyper-CVAD regimen.
Lymphoma, Mantle-Cell
Topoisomerase IIalpha as a prognostic factor in mantle cell lymphoma.
Lymphoma, Mantle-Cell
Topoisomerase IIalpha expression in mantle cell lymphoma: a marker of cell proliferation and a prognostic factor for clinical outcome.
Lymphoma, Non-Hodgkin
Acute promyelocytic leukemia after treatment for non-Hodgkin's lymphoma with drugs targeting topoisomerase II.
Lymphoma, Non-Hodgkin
Feasibility of salvage chemotherapy for refractory or relapsed non-Hodgkin's lymphoma with two topoisomerase II inhibitors, MST-16 and VP-16. MST-16 Study Group.
Lymphoma, Non-Hodgkin
Inversion of chromosome 11 inv(11)(p15q22), as a recurring chromosomal aberration associated with de novo and secondary myeloid malignancies: identification of a P1 clone spanning the 11q22 breakpoint.
Lymphoma, Non-Hodgkin
Long-term administration of oral low-dose topoisomerase II inhibitors, MST-16 and VP-16, for refractory or relapsed non-Hodgkin's lymphoma.
Lymphoma, Non-Hodgkin
Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II.
Lymphoma, Non-Hodgkin
The distribution and expression of the two isoforms of DNA topoisomerase II in normal and neoplastic human tissues.
Lymphoma, Non-Hodgkin
Therapy-related acute myelogenous leukemia associated with 11q23 chromosomal abnormalities and topoisomerase II inhibitors: report of four additional cases and brief commentary.
Lymphoma, Non-Hodgkin
Topoisomerase II alpha mRNA and tumour cell proliferation in non-Hodgkin's lymphoma.
Lymphoma, Non-Hodgkin
Unexpected hepatotoxicities in patients with non-Hodgkin's lymphoma treated with irinotecan (CPT-11) and etoposide.
Lymphoma, T-Cell
Enzyme histochemistry of non-Hodgkin's lymphomas.
Lymphoma, T-Cell, Peripheral
nm23, TOP2A and VEGF expression: Potential prognostic biologic factors in peripheral T-cell lymphoma, not otherwise specified.
Lymphoproliferative Disorders
Evaluation of the MDR1, ABCG2, Topoisomerases IIalpha and GSTpi gene expression in patients affected by aggressive mantle cell lymphoma treated by the R-Hyper-CVAD regimen.
Machado-Joseph Disease
Functional ATPase activity of p97/valosin-containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells.
Macular Degeneration
The effect of lipid environment and retinoids on the ATPase activity of ABCR, the photoreceptor ABC transporter responsible for Stargardt macular dystrophy.
Magnesium Deficiency
Digoxin and membrane sodium potassium ATPase inhibition in cardiovascular disease.
Magnesium Deficiency
Magnesium deficiency: Does it have a role to play in cataractogenesis?
Magnesium Deficiency
Metabolic activity of liver mitochondria from magnesium-deficient rats.
Magnesium Deficiency
Pathogenetic role of magnesium deficiency in ophthalmic diseases.
Magnesium Deficiency
Relation between potassium, magnesium and cardiac arrhythmias.
Magnesium Deficiency
[Magnesium intake and cardiovascular disease]
Malabsorption Syndromes
Studies on the malabsorption syndromes. Inhibition of (Na+-K+) ATPase of small intestine microvilli by pyrrolidone carboxylic acid.
Malaria
A Comprehensive Review on DNA Gyrase Inhibitors.
Malaria
Artemisinin-Resistant Mutants of Toxoplasma gondii Have Altered Calcium Homeostasis.
Malaria
Assessment and Characterization of Ca2+ - ATPase expression in selected isolates and clones of Plasmodium Falciparum.
Malaria
ATPase activity of Plasmodium falciparum MLH is inhibited by DNA-interacting ligands and dsRNAs of MLH along with UvrD curtail malaria parasite growth.
Malaria
ATPase activity of purified plasma membranes and digestive vacuoles from Plasmodium falciparum.
Malaria
Cleavage of DNA induced by 9-anilinoacridine inhibitors of topoisomerase II in the malaria parasite Plasmodium falciparum.
Malaria
Expression and characterization of the ATP-binding domain of a malarial Plasmodium vivax gene homologous to the B-subunit of the bacterial topoisomerase DNA gyrase.
Malaria
Gametocytocidal activity of pyronaridine and DNA topoisomerase II inhibitors against multidrug-resistant Plasmodium falciparum in vitro.
Malaria
Heat shock protein 90 as a drug target against protozoan infections: Biochemical characterization of Hsp90 from Plasmodium falciparum, Trypanosoma evansi and evaluation of its inhibitor as a candidate drug.
Malaria
Inhibition of Plasmodium falciparum proliferation in vitro by double-stranded RNA nanoparticle against malaria topoisomerase II.
Malaria
Molecular epidemiology of malaria in Cameroon. XXVIII. In vitro activity of dihydroartemisinin against clinical isolates of Plasmodium falciparum and sequence analysis of the P. falciparum ATPase 6 gene.
Malaria
Molecular epidemiology of malaria in Cameroon. XXX. sequence analysis of Plasmodium falciparum ATPase 6, dihydrofolate reductase, and dihydropteroate synthase resistance markers in clinical isolates from children treated with an artesunate-sulfadoxine-pyrimethamine combination.
Malaria
Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials.
Malaria
Parasite plastids: maintenance and functions.
Malaria
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Malaria
Polymorphisms of molecular markers of antimalarial drug resistance and relationship with artesunate-mefloquine combination therapy in patients with uncomplicated Plasmodium falciparum malaria in Thailand.
Malaria
Properties of Plasmodium falciparum with a Deleted Apicoplast DNA Gyrase.
Malaria
Selection of Plasmodium falciparum multidrug resistance gene 1 alleles in asexual stages and gametocytes by artemether-lumefantrine in Nigerian children with uncomplicated falciparum malaria.
Malaria
The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs.
Malaria
Therapeutic efficacy of artesunate in the treatment of uncomplicated Plasmodium falciparum malaria and anti-malarial, drug-resistance marker polymorphisms in populations near the China- Myanmar border.
Malaria
Topoisomerase II from Human Malaria Parasites: EXPRESSION, PURIFICATION, AND SELECTIVE INHIBITION.
Malaria, Falciparum
Polymorphisms of molecular markers of antimalarial drug resistance and relationship with artesunate-mefloquine combination therapy in patients with uncomplicated Plasmodium falciparum malaria in Thailand.
Malaria, Falciparum
Therapeutic efficacy of artesunate in the treatment of uncomplicated Plasmodium falciparum malaria and anti-malarial, drug-resistance marker polymorphisms in populations near the China- Myanmar border.
Malnutrition
Effect of nutritional status and ozone exposure on some biomarkers of oxidative stress in rat brain regions.
Malnutrition
Effects of malnutrition and quipazine on rat cerebral cortex ATPase activity during development.
Malnutrition
Effects of thyroid hormones on contractility and cation transport in skeletal muscle.
Malnutrition
Nutrition and growth.
Malnutrition
Undernutrition during the preweaning period changes calcium ATPase and ADPase activities of synaptosomal fractions of weanling rats.
Mania
Effects of mood stabilizers on hippocampus and amygdala BDNF levels in an animal model of mania induced by ouabain.
Mania
Erythrocyte membrane cation carrier in mania.
Mania
Lifelong consumption of trans fatty acids promotes striatal impairments on Na(+)/K(+) ATPase activity and BDNF mRNA expression in an animal model of mania.
Mania
RBC membrane adenosine triphosphatase activities in patients with major affective disorders.
Massive Hepatic Necrosis
Methanobactin reverses acute liver failure in a rat model of Wilson disease.
Mastitis
[ATPase activity in cows' milk in latent mastitis]
Mastocytoma
Inhibition of protein synthesis reduces the cytotoxicity of 4'-(9-acridinylamino)methanesulfon-m-anisidide without affecting DNA breakage and DNA topoisomerase II in a murine mastocytoma cell line.
Mastocytoma
Regulation of topoisomerase II by murine mastocytoma cells.
Mastocytoma
Relationship between sensitivity to 4'-(9-acridinylamino)methanesulfon-m-anisidide and DNA topoisomerase II in a cold-sensitive cell-cycle mutant of a murine mastocytoma cell line.
Medulloblastoma
BAF complexes facilitate decatenation of DNA by topoisomerase II?.
Medulloblastoma
Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity.
Medulloblastoma
Rethinking medulloblastoma from a targeted therapeutics perspective.
Medulloblastoma
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Megalencephaly
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Melanoma
A novel mutant topoisomerase II alpha present in VP-16-resistant human melanoma cell lines has a deletion of alanine 429.
Melanoma
Abnormal acidification of melanoma cells induces tyrosinase retention in the early secretory pathway.
Melanoma
Acidic Stress Triggers Sodium-Coupled Bicarbonate Transport and Promotes Survival in A375 Human Melanoma Cells.
Melanoma
Acquisition of multiple copies of a mutant topoisomerase IIalpha allele by chromosome 17 aneuploidy is associated with etoposide resistance in human melanoma cell lines.
Melanoma
Adenovirus-mediated E2F-1 gene transfer sensitizes melanoma cells to apoptosis induced by topoisomerase II inhibitors.
Melanoma
ASNA1, an ATPase targeting tail-anchored proteins, regulates melanoma cell growth and sensitivity to cisplatin and arsenite.
Melanoma
Boswellic acid acetate induces differentiation and apoptosis in highly metastatic melanoma and fibrosarcoma cells.
Melanoma
Characterization of an unusual mutant of human melanoma cells resistant to anticancer drugs that inhibit topoisomerase II.
Melanoma
Comparison of 5'-nucleotidase activities among cultured murine melanoma cell lines.
Melanoma
Dipyridamole reverses the resistance to topoisomerase II inhibitors but not to antimicrotubule agents in multidrug-resistant melanoma cells.
Melanoma
Doxorubicin-induced DNA breaks, topoisomerase II activity and gene expression in human melanoma cells.
Melanoma
Dual inhibition of topoisomerases enhances apoptosis in melanoma cells.
Melanoma
E2F-dependent repression of topoisomerase II regulates heterochromatin formation and apoptosis in cells with melanoma-prone mutation.
Melanoma
Effect of structural modification at the 4, 3', and 2' positions of doxorubicin on topoisomerase II poisoning, apoptosis, and cytotoxicity in human melanoma cells.
Melanoma
Effects of human transforming growth factors on topoisomerases from normal fibroblasts.
Melanoma
Evaluation of MDR1, LRP, MRP, and topoisomerase IIalpha gene mRNA transcripts before and after interferon-alpha, and correlation with the mRNA expression level of the telomerase subunits hTERT and TEP1 in five unselected human melanoma cell lines.
Melanoma
Expression of DNA topoisomerase I, DNA topoisomerase II-alpha, and p53 in metastatic malignant melanoma.
Melanoma
Genistein-induced cell differentiation and protein-linked DNA strand breakage in human melanoma cells.
Melanoma
Heterogeneous SWI/SNF chromatin remodeling complexes promote expression of microphthalmia-associated transcription factor target genes in melanoma.
Melanoma
Histone Deacetylase Inhibitor Treatment Increases the Expression of the Plasma Membrane Ca(2+) Pump PMCA4b and Inhibits the Migration of Melanoma Cells Independent of ERK.
Melanoma
Identification of key candidate genes involved in melanoma metastasis.
Melanoma
Identification of potential therapeutic targets for melanoma using gene expression analysis.
Melanoma
Inhibition of potentially lethal and sublethal damage repair by camptothecin and etoposide in human melanoma cell lines.
Melanoma
Inhibition of potentially lethal DNA damage repair in human tumor cells by beta-lapachone, an activator of topoisomerase I.
Melanoma
INO80 governs superenhancer-mediated oncogenic transcription and tumor growth in melanoma.
Melanoma
Isolation and characterization of plasma membranes from transplantable human astrocytoma, oat cell carcinoma, and melanomas.
Melanoma
Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance.
Melanoma
Molecular classification of melanoma using real-time quantitative reverse transcriptase-polymerase chain reaction.
Melanoma
Nitric Oxide Down-Regulates Topoisomerase I and Induces Camptothecin Resistance in Human Breast MCF-7 Tumor Cells.
Melanoma
Oxidative phosphorylation and ATPase activities of human tumor mitochondria.
Melanoma
Profiles of brain metastases: Prioritization of therapeutic targets.
Melanoma
Prognostic Values of Filamin-A Status for Topoisomerase II Poison Chemotherapy.
Melanoma
Relationship between expression of topoisomerase II isoforms and chemosensitivity in choroidal melanoma.
Melanoma
Synthesis and identification of novel indolo[2,3-a]pyrimido[5,4-c]carbazoles as a new class of anti-cancer agents.
Melanoma
The immunohistochemical profile of Spitz nevi and conventional (non-Spitzoid) melanomas: a baseline study.
Melanoma
The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.
Melanoma
The plasma membrane Ca(2+) pump PMCA4b inhibits the migratory and metastatic activity of BRAF mutant melanoma cells.
Melanoma
The role of the cancer stem cell marker CD271 in DNA damage response and drug resistance of melanoma cells.
Melanoma
Topoisomerase II alpha expression and cytotoxicity of anthracyclines in human neoplastic cells.
Melanoma
Unbiased High-Throughput Drug Combination Pilot Screening Identifies Synergistic Drug Combinations Effective against Patient-Derived and Drug-Resistant Melanoma Cell Lines.
Melanoma
[Correlation of the expression of MDR genes and MDR genes-coded product with prognosis in laryngopharyngeal malignant melanoma]
Melanoma
[Drug resistance of malignant melanoma. Mechanisms and possible modulation]
Melanoma, Experimental
Fusion protein of ATPase domain of Hsc70 with TRP2 acting as a tumor vaccine against B16 melanoma.
Melanoma, Experimental
The DNA intercalating alkaloid cryptolepine interferes with topoisomerase II and inhibits primarily DNA synthesis in B16 melanoma cells.
MELAS Syndrome
Inheritance and expression of mitochondrial DNA point mutations.
Melioidosis
Burkholderia pseudomallei type III secretion system cluster 3 ATPase BsaS: a chemotherapeutic target for small molecule ATPase inhibitors.
Melioidosis
Revisiting aminocoumarins for the treatment of melioidosis.
Memory Disorders
Folic Acid Can Contribute to Memory Deficit and Na+, K+- ATPase Failure in the Hippocampus of Adolescent Rats Submitted to Hypoxia- Ischemia.
Memory Disorders
Gestational folic acid supplementation does not affects the maternal behavior and the early development of rats submitted to neonatal hypoxia-ischemia but the high supplementation impairs the dam's memory and the Na+, K+ - ATPase activity in the pup's hippocampus.
Meningioma
Clinicopathological variables, immunophenotype, chromosome 1p36 loss and tumour recurrence of 247 meningiomas grade I and II.
Meningioma
DNA topoisomerase II-alpha and cyclin A immunoexpression in meningiomas and its prognostic significance: an analysis of 263 cases.
Meningioma
DNA topoisomerase IIalpha expression correlates with cell proliferation but not with recurrence in intracranial meningiomas.
Meningioma
DNA topoisomerase IIalpha protein and mRNA expression in intracranial meningiomas.
Meningioma
Effect of LINAC radiosurgery on regional cerebral blood flow, glucose metabolism and sodium-potassium AtPase in skull base meningiomas and metastasis.
Meningioma
Identification of gene markers associated with aggressive meningioma by filtering across multiple sets of gene expression arrays.
Meningioma
Immunohistochemical analysis of p16INK4a, p14ARF, p18INK4c, p21CIP1, p27KIP1 and p73 expression in 271 meningiomas correlation with tumor grade and clinical outcome.
Meningioma
Intrinsic expression of drug resistance-associated factors in meningiomas.
Meningioma
Multiplatform profiling of meningioma provides molecular insight and prioritization of drug targets for rational clinical trial design.
Meningioma
Topoisomerase II alpha as a reliable proliferation marker in meningiomas.
Meningioma
[A case of malignant meningioma treated by individual adjuvant chemotherapy based on the mRNA expression of drug-resistance gene]
Meningioma
[Difference in 201TlCl accumulation mechanism in brain tumors: a comparison of their Na(+)-K+ ATPase activities]
Meningioma
[Immunohistochemical evaluation of intracranial recurrent meningiomas: correlation of topoisomerase II alpha expression and cell proliferative potential]
Meningioma
[Proliferative markers of meningiomas: immunohistochemical analysis and prognostic value]
Meningitis
[The dynamics of erythrocyte metabolism in severe forms of meningococcal infection and suppurative meningitis in children]
Meningococcal Infections
Evolutionary analysis of gyrA gene from Neisseria meningitidis bacterial strains of clonal complex 4821 collected in China between 1978 and 2016.
Meningococcal Infections
[The dynamics of erythrocyte metabolism in severe forms of meningococcal infection and suppurative meningitis in children]
Menkes Kinky Hair Syndrome
A murine model of Menkes disease reveals a physiological function of metallothionein.
Menkes Kinky Hair Syndrome
Actin and microtubule regulation of trans-Golgi network architecture, and copper-dependent protein transport to the cell surface.
Menkes Kinky Hair Syndrome
Adipocyte-specific disruption of ATPase copper transporting ? in mice accelerates lipoatrophy.
Menkes Kinky Hair Syndrome
Copper efflux from murine microvascular cells requires expression of the menkes disease Cu-ATPase.
Menkes Kinky Hair Syndrome
Functional analysis of a genetic defect of copper transport (Menkes disease) in different cell lines.
Menkes Kinky Hair Syndrome
Menkes disease.
Menkes Kinky Hair Syndrome
Mutation analysis provides additional proof that mottled is the mouse homologue of Menkes' disease.
Menkes Kinky Hair Syndrome
Novel membrane traffic steps regulate the exocytosis of the Menkes disease ATPase.
Menkes Kinky Hair Syndrome
P-type ATPase from the cyanobacterium Synechococcus 7942 related to the human Menkes and Wilson disease gene products.
Menkes Kinky Hair Syndrome
Pretranslational control of Menkes disease gene expression.
Menkes Kinky Hair Syndrome
Structure of the actuator domain from the Archaeoglobus fulgidus Cu(+)-ATPase.
Menkes Kinky Hair Syndrome
The Menkes disease ATPase (ATP7A) is internalized via a Rac1-regulated, clathrin- and caveolae-independent pathway.
Menkes Kinky Hair Syndrome
The Wilson disease gene is a putative copper transporting P-type ATPase similar to the Menkes gene.
Menkes Kinky Hair Syndrome
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Menkes Kinky Hair Syndrome
Whole-Exome Sequencing, Proteome Landscape, and Immune Cell Migration Patterns in a Clinical Context of Menkes Disease.
Menkes Kinky Hair Syndrome
[Biological regulation of copper and selective removal of copper: therapy for Wilson disease and its molecular mechanism]
Menkes Kinky Hair Syndrome
[Identification of a fragment of ceruloplasmin, interacting with copper-transporting Menkes ATPase]
MERRF Syndrome
A calcium signaling defect in the pathogenesis of a mitochondrial DNA inherited oxidative phosphorylation deficiency.
MERRF Syndrome
Inheritance and expression of mitochondrial DNA point mutations.
Mesothelioma
Amphotericin B-induced apoptosis and cytotoxicity is prevented by the Na+, K+, 2Cl(-)-cotransport blocker bumetanide.
Mesothelioma
Bumetanide annihilation of amphotericin B-induced apoptosis and cytotoxicity is due to its effect on cellular K+ flux.
Mesothelioma
Expression and integrity of DNA topoisomerase II isoforms does not explain generic drug resistance in malignant mesothelioma.
Mesothelioma
Novel acridine-based agents with topoisomerase II inhibitor activity suppress mesothelioma cell proliferation and induce apoptosis.
Mesothelioma
Zoledronic acid induces apoptosis and S-phase arrest in mesothelioma through inhibiting Rab family proteins and topoisomerase II actions.
Mesothelioma, Malignant
Differential diagnosis of reactive mesothelial cells and malignant mesothelioma cells using the cell proliferation markers minichromosome maintenance protein 7, geminin, topoisomerase II alpha and Ki-67.
Mesothelioma, Malignant
Expression and integrity of DNA topoisomerase II isoforms does not explain generic drug resistance in malignant mesothelioma.
Mesothelioma, Malignant
Novel acridine-based agents with topoisomerase II inhibitor activity suppress mesothelioma cell proliferation and induce apoptosis.
Metabolic Diseases
Chronic extracellular acidosis induces plasmalemmal vacuolar type H+ ATPase activity in osteoclasts.
Metabolic Diseases
Identification of mutations in the ATP7B gene in 14 Wilson disease children: Case series.
Metabolic Diseases
Therapeutic potential of hepatocyte-like-cells converted from stem cells from human exfoliated deciduous teeth in fulminant Wilson's disease.
Metabolic Syndrome
In Vivo Exposures to Particulate Matter Collected from Saudi Arabia or Nickel Chloride Display Similar Dysregulation of Metabolic Syndrome Genes.
Microphthalmos
Cyclin A2/cyclin-dependent kinase 1-dependent phosphorylation of Top2a is required for S phase entry during retinal development in zebrafish.
Microphthalmos
SMCHD1 mutation spectrum for facioscapulohumeral muscular dystrophy type 2 (FSHD2) and Bosma arhinia microphthalmia syndrome (BAMS) reveals disease-specific localisation of variants in the ATPase domain.
Migraine Disorders
Abnormalities of Na/K ATPase in migraine with aura.
Migraine Disorders
Astrocyte deletion of ?2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway.
Migraine Disorders
Capillary Endothelial Na(+), K(+), ATPase Transporter Homeostasis and a New Theory for Migraine Pathophysiology.
Migraine Disorders
Defective glutamate and K+ clearance by cortical astrocytes in familial hemiplegic migraine type 2.
Migraine Disorders
Multilevel somatosensory system disinhibition in children with migraine.
Migraine Disorders
No evidence of ATP1A2 involvement in 12 multiplex Italian families with benign familial infantile seizures.
Migraine Disorders
Novel mutations affecting the Na, K ATPase alpha model complex neurological diseases and implicate the sodium pump in increased longevity.
Migraine Disorders
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Migraine Disorders
[Genetic analysis of migraine headache: a review]
Migraine Disorders
[Genetics of migraines: from ionic channels to single nucleotide polymorphisms?]
Migraine with Aura
Abnormalities of Na/K ATPase in migraine with aura.
Migraine with Aura
Astrocyte deletion of ?2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway.
Migraine with Aura
Defective glutamate and K+ clearance by cortical astrocytes in familial hemiplegic migraine type 2.
Migraine with Aura
No evidence of ATP1A2 involvement in 12 multiplex Italian families with benign familial infantile seizures.
Migraine with Aura
Novel mutations affecting the Na, K ATPase alpha model complex neurological diseases and implicate the sodium pump in increased longevity.
Migraine with Aura
[Genetic analysis of migraine headache: a review]
Migraine with Aura
[Genetics of migraines: from ionic channels to single nucleotide polymorphisms?]
Miosis
DNA topoisomerase II is required at the time of mitosis in yeast.
Mitochondrial Diseases
A calcium signaling defect in the pathogenesis of a mitochondrial DNA inherited oxidative phosphorylation deficiency.
Mitochondrial Diseases
Heterogeneous patterns of tissue injury in NARP syndrome.
Mitochondrial Diseases
Mitochondrial diseases and ATPase defects of nuclear origin.
Mitochondrial Diseases
NARP Syndrome: A 20-Year Follow-Up.
Mitochondrial Diseases
Reduced respiratory control with ADP and changed pattern of respiratory chain enzymes as a result of selective deficiency of the mitochondrial ATP synthase.
Mitochondrial Diseases
Rescue of a deficiency in ATP synthesis by transfer of MTATP6, a mitochondrial DNA-encoded gene, to the nucleus.
Mitochondrial Diseases
Skd3 (human ClpB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations.
Mitochondrial Myopathies
Distribution of the ATPase inhibitor proteins of mitochondria in mammalian tissues including fibroblasts from a patient with Luft's disease.
Mitral Valve Insufficiency
Cardiac intracellular and blood electrolytes in chronic mitral insufficiency.
Mitral Valve Insufficiency
Effect of prazosin treatment on the cardiac sarcolemmal ATPase in failing heart due to mitral insufficiency in dogs.
Mitral Valve Insufficiency
Effects of chronic digoxin treatment on cardiac function, electrolytes, and sarcolemmal ATPase in the canine failing heart due to chronic mitral regurgitation.
Mitral Valve Insufficiency
Maximal actomyosin ATPase activity and in vitro myosin motility are unaltered in human mitral regurgitation heart failure.
Mitral Valve Insufficiency
Myocardial sarcolemmal ATPase in dogs with induced mitral insufficiency.
Mitral Valve Insufficiency
[Changes in ATPase activity and nonesterified fatty acid concentration in heart and liver mitochondria in experimental mitral valve insufficiency]
Motor Neuron Disease
Digoxin : a model for hypothalamic regulation of neuronal transmission, endocrine function, immunity and cytodifferentiation.
Motor Neuron Disease
Neuromuscular junction defects in mice with mutation of dynein heavy chain 1.
Motor Neuron Disease
The N-terminal Region of the Ubiquitin Regulatory X (UBX) Domain-containing Protein 1 (UBXD1) Modulates Interdomain Communication within the Valosin-containing Protein p97.
Mouth Neoplasms
A novel peroxisome proliferator-activated receptor alpha/gamma agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells.
Movement Disorders
Regulation of Torsin ATPases by LAP1 and LULL1.
Movement Disorders
Stiff person syndrome and other immune-mediated movement disorders - new insights.
Movement Disorders
Twisting mice move the dystonia field forward.
Moyamoya Disease
Biochemical and Functional Characterization of RNF213 (Mysterin) R4810K, a Susceptibility Mutation of Moyamoya Disease, in Angiogenesis In Vitro and In Vivo.
Moyamoya Disease
The susceptibility pathogenesis of the moyamoya disease.
Multiple Myeloma
Cell density-dependent VP-16 sensitivity of leukaemic cells is accompanied by the translocation of topoisomerase IIalpha from the nucleus to the cytoplasm.
Multiple Myeloma
Decreased CP-1 (NF-Y) activity results in transcriptional down-regulation of topoisomerase IIalpha in a doxorubicin-resistant variant of human multiple myeloma RPMI 8226.
Multiple Myeloma
DNA topoisomerase IIalpha in multiple myeloma: a marker of cell proliferation and not drug resistance.
Multiple Myeloma
Erythrocyte enzymes in myelomatosis.
Multiple Myeloma
Expressions of DNA topoisomerase I and II gene and the genes possibly related to drug resistance in human myeloma cells.
Multiple Myeloma
Human multiple myeloma cells are sensitized to topoisomerase II inhibitors by CRM1 inhibition.
Multiple Myeloma
Synergistic interaction of proteasome and topoisomerase II inhibition in multiple myeloma.
Multiple Myeloma
Treatment of acquired drug resistance in multiple myeloma by combination therapy with XPO1 and topoisomerase II inhibitors.
Multiple Myeloma
Whole genome CRISPR screening identifies TOP2B as a potential target for IMiD sensitization in multiple myeloma.
Multiple Myeloma
[Biological characteristics of multiple myeloma]
Multiple Myeloma
[The significance of the cytochemical adenosine triphosphatase reaction for the diagnosis of benign monoclonal gammopathy (author's transl)]
Multiple Sclerosis
Acute promyelocytic leukemic involvement of the optic nerves following mitoxantrone treatment for multiple sclerosis.
Multiple Sclerosis
Digoxin : a model for hypothalamic regulation of neuronal transmission, endocrine function, immunity and cytodifferentiation.
Multiple Sclerosis
Investigation on mitochondrial tRNA(Leu/Lys), NDI and ATPase 6/8 in Iranian multiple sclerosis patients.
Multiple Sclerosis
Isoprenoid pathway and free radical generation and damage in neuropsychiatric disorders.
Multiple Sclerosis
Signaling pathway involved in the inhibitory effect of FTY720P on the Na(+)/K(+) ATPase in HepG2 cells.
Multiple Sclerosis
Therapy-related acute promyelocytic leukemia: a systematic review.
Multiple Sclerosis
[Disordered lipid peroxidation and ATPase activities in patients with disseminated sclerosis]
Multiple Sclerosis
[Prognostic value of NA K ATPase activity in multiple sclerosis]
Muscle Cramp
Brody syndrome: A clinically heterogeneous entity distinct from Brody disease: A review of literature and a cross-sectional clinical study in 17 patients.
Muscle Hypotonia
[Congenital desproportion of various types of muscle fiber, with relative small size of type I fibers. Morphological documents on muscle biopsies in 3 members of the same family]
Muscle Spasticity
Expanding the clinical and genetic heterogeneity of SPAX5.
Muscle Weakness
A calcium signaling defect in the pathogenesis of a mitochondrial DNA inherited oxidative phosphorylation deficiency.
Muscle Weakness
Catalytic activities of mitochondrial ATP synthase in patients with mitochondrial DNA T8993G mutation in the ATPase 6 gene encoding subunit a.
Muscle Weakness
Diseases resulting from mitochondrial DNA point mutations.
Muscle Weakness
Molecular Mechanisms of Muscle Weakness Associated with E173A Mutation in Tpm3.12. Troponin Ca2+ Sensitivity Inhibitor W7 Can Reduce the Damaging Effect of This Mutation.
Muscle Weakness
Molecular Mechanisms of the Deregulation of Muscle Contraction Induced by the R90P Mutation in Tpm3.12 and the Weakening of This Effect by BDM and W7.
Muscle Weakness
The aleu207-->arg mutation in F1F0-ATP synthase from Escherichia coli. A model for human mitochondrial disease.
Muscular Atrophy
Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness.
Muscular Atrophy
The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins.
Muscular Atrophy
[Basic results of an experiment with mammals on the Kosmos-782 biosatellite]
Muscular Atrophy
[Examination of skeletal muscles of rats after a short-term flight on Cosmos-1667]
Muscular Atrophy
[Histochemical study of the skeletal muscle in chronic alcoholism]
Muscular Atrophy
[Na+ + K+] Mg2+-ATPase of muscle plasma membranes in Duchenne muscular dystrophy.
Muscular Atrophy, Spinal
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Muscular Diseases
A new familial congenital myopathy in children with desmin and dystrophin reacting plaques.
Muscular Diseases
Aberrant movement of ?-tropomyosin associated with congenital myopathy causes defective response of myosin heads and actin during the ATPase cycle.
Muscular Diseases
Altered cofactor regulation with disease-associated p97/VCP mutations.
Muscular Diseases
Brody syndrome: A clinically heterogeneous entity distinct from Brody disease: A review of literature and a cross-sectional clinical study in 17 patients.
Muscular Diseases
Cannabinoid signalling inhibits sarcoplasmic Ca(2+) release and regulates excitation-contraction coupling in mammalian skeletal muscle.
Muscular Diseases
Characterization of sarcoplasmic reticulum Ca(2+) ATPase pumps in muscle of patients with myotonic dystrophy and with hypothyroid myopathy.
Muscular Diseases
Congenital myopathy with mosaic fibers and interlacing sarcomeres: a new structural myopathy.
Muscular Diseases
Correlations between histochemical and ultrastructural studies of diseased muscle.
Muscular Diseases
Enhanced ATPase activities as a primary defect of mutant valosin-containing proteins that cause inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia.
Muscular Diseases
Experimental corticosteroid myopathy: effect on myofibrillar ATPase activity and protein degradation.
Muscular Diseases
Giardiasis as a cause of hypokalemic myopathy in congenital immunodeficiency.
Muscular Diseases
Muscle pathology and whole-body MRI in a polyglucosan myopathy associated with a novel glycogenin-1 mutation.
Muscular Diseases
Myosin storage myopathy: slow skeletal myosin (MYH7) mutation in two isolated cases.
Muscular Diseases
p97-containing complexes in proliferation control and cancer: emerging culprits or guilt by association?
Muscular Diseases
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Muscular Diseases
The N-terminal Region of the Ubiquitin Regulatory X (UBX) Domain-containing Protein 1 (UBXD1) Modulates Interdomain Communication within the Valosin-containing Protein p97.
Muscular Diseases
The Role of the N-Domain in the ATPase Activity of the Mammalian AAA ATPase p97/VCP.
Muscular Dystrophies
Adenylate cyclase in muscular dystrophy.
Muscular Dystrophies
Characterization of ATPase in sarcoplasmic reticulum from two strains of dystrophic mice.
Muscular Dystrophies
Erythrocyte flexibility, ATPase activities and Ca efflux in patients with Duchenne muscular dystrophy, myotonic muscular dystrophy and congenital myotonia.
Muscular Dystrophies
Erythrocyte ghost (Na+ + K+) ATPase activity in mice with hereditary muscular dystrophy (strain C57 BL/64J/dy).
Muscular Dystrophies
Erythrocyte membrane cation-stimulated ATPase activities in myotonic muscular dystrophy.
Muscular Dystrophies
Na+ + K+ ATPase of erythrocyte membrane in progressive muscular dystrophy.
Muscular Dystrophies
[ATPase systems of the skeletal muscle sarcolemma in E-avitaminotic muscular dystrophy]
Muscular Dystrophies
[Availability of Mg2+, Na+, and K+-ATPase in the nuclei of the skeletal muscles of rabbits normally and during experimental muscular dystrophy]
Muscular Dystrophies
[Changes in the ATP-ase activity of skeletal muscle nuclei of rabbits with dystrophy and following their delipidation]
Muscular Dystrophies
[Histochemistry of skeletal muscle ATPase in neuromuscular diseases, with special reference to progressive muscular dystrophy]
Muscular Dystrophies
[Mg 2+, Ca 2+-ATPase of skeletal muscle nuclei in normal rabbits and in rabbits with experimental muscular dystrophy]
Muscular Dystrophy, Duchenne
Adenylate cyclase and ATPase activities in red cell membranes of patients and genetic carriers of Duchenne muscular dystrophy.
Muscular Dystrophy, Duchenne
Erythrocyte flexibility, ATPase activities and Ca efflux in patients with Duchenne muscular dystrophy, myotonic muscular dystrophy and congenital myotonia.
Muscular Dystrophy, Duchenne
Erythrocyte-ghost Ca2+-stimulated Mg2+-dependent adenosine triphosphatase in Duchenne muscular dystrophy.
Muscular Dystrophy, Duchenne
Histochemical fibre typing and ultrastructure of the small fibres in Duchenne muscular dystrophy.
Muscular Dystrophy, Duchenne
Importance of monitoring calcium & calcium related properties in carrier detection for Duchenne muscular dystrophy.
Muscular Dystrophy, Duchenne
Increased sarcolipin expression and decreased sarco(endo)plasmic reticulum Ca(2+) uptake in skeletal muscles of mouse models of Duchenne muscular dystrophy.
Muscular Dystrophy, Duchenne
Na+ + K+ ATPase of erythrocyte membranes in Duchenne muscular dystrophy.
Muscular Dystrophy, Duchenne
The significance of type 2C muscle fibers in Duchenne muscular dystrophy.
Muscular Dystrophy, Facioscapulohumeral
SMCHD1 mutation spectrum for facioscapulohumeral muscular dystrophy type 2 (FSHD2) and Bosma arhinia microphthalmia syndrome (BAMS) reveals disease-specific localisation of variants in the ATPase domain.
Myasthenia Gravis
Successful salvage chemotherapy with amrubicin for invasive thymoma associated with myasthenia gravis.
Mycoses
A Comprehensive Review on DNA Gyrase Inhibitors.
Mycosis Fungoides
[A comparative study of the quantitative distribution and ultrastructure of Langerhans cells in the epidermis of patients with chronic benign dermatoses and mycosis fungoides]
Myelodysplastic Syndromes
Amplification of ERBB2, RARA, and TOP2A genes in a myelodysplastic syndrome transforming to acute myeloid leukemia.
Myelodysplastic Syndromes
Association of Chemotherapy for Solid Tumors With Development of Therapy-Related Myelodysplastic Syndrome or Acute Myeloid Leukemia in the Modern Era.
Myelodysplastic Syndromes
Epigenetic Combination Therapy for Children With Secondary Myelodysplastic Syndrome (MDS)/Acute Myeloid Leukemia (AML) and Concurrent Solid Tumor Relapse.
Myelodysplastic Syndromes
Panhandle PCR approaches to cloning MLL genomic breakpoint junctions and fusion transcript sequences.
Myelodysplastic Syndromes
Potential role for DNA topoisomerase II poisons in the generation of t(11;20)(p15;q11) translocations.
Myelodysplastic Syndromes
Predictors of outcome following myeloablative allo-SCT for therapy-related myelodysplastic syndrome and AML.
Myelodysplastic Syndromes
Rearrangement of the Myeloid/Lymphoid Leukemia Gene in Therapy-Related Myelodysplastic Syndrome in Patients Previously Treated with Agents Targeting DNA Topoisomerase II.
Myelodysplastic Syndromes
Second malignancies following adjuvant chemotherapy: 6-year results from a Belgian randomized study comparing cyclophosphamide, methotrexate and 5-fluorouracil (CMF) with an anthracycline-based regimen in adjuvant treatment of node-positive breast cancer patients.
Myelodysplastic Syndromes
T-cell acute lymphoblastic leukemia as a secondary leukemia after a 3-year remission of acute myelocytic leukemia.
Myelodysplastic Syndromes
Therapy-related leukemia and myelodysplastic syndrome: a large-scale Japanese study of clinical and cytogenetic features as well as prognostic factors.
Myelodysplastic Syndromes
Treatment-related myelodysplasia in patients with primary brain tumors.
Myelodysplastic Syndromes
[Chromosome translocations and leukemias induced by inhibitors of topoisomerase II anticarcinogenic drugs]
Myeloproliferative Disorders
Translocation (3;21)(q26;q22) in therapy-related myelodysplasia following drugs targeting DNA-topoisomerase II combined with alkylating agents, and in myeloproliferative disorders undergoing spontaneous leukemic transformation.
Myocardial Infarction
(-)Epigallocatechingallate protects the mitochondria against the deleterious effects of lipids, calcium and adenosine triphosphate in isoproterenol induced myocardial infarcted male Wistar rats.
Myocardial Infarction
Captopril treatment improves the sarcoplasmic reticular Ca(2+) transport in heart failure due to myocardial infarction.
Myocardial Infarction
Cardiomyopathies and mitochondrial DNA mutations.
Myocardial Infarction
Cardioprotective effect of salvianolic acid B on large myocardial infarction mediated by reversing upregulation of leptin, endothelin pathways, and abnormal expression of SERCA2a, phospholamban in rats.
Myocardial Infarction
Cardioprotective Effects of Combined Therapy with Hyperbaric Oxygen and Diltiazem Pretreatment on Myocardial Ischemia-Reperfusion Injury in Rats.
Myocardial Infarction
Decreased expression of cardiac sarcoplasmic reticulum Ca(2+)-pump ATPase in congestive heart failure due to myocardial infarction.
Myocardial Infarction
Effect of Atorvastatin Treatment on Isoproterenol-Induced Myocardial Infarction in Rats.
Myocardial Infarction
Electron microscopic studies on ATPase activities in myocardial infarction.
Myocardial Infarction
Electron microscopic studies on the ATPase activity in myocardial infarction -changes in the early myocardial infarction.
Myocardial Infarction
Gastrodin Pretreatment Impact on Sarcoplasmic Reticulum Calcium Transport ATPase (SERCA) and Calcium Phosphate (PLB) Expression in Rats with Myocardial Ischemia Reperfusion.
Myocardial Infarction
Influence of apelin-12 on troponin levels and the rate of MACE in STEMI patients.
Myocardial Infarction
Influence of long-term treatment of imidapril on mortality, cardiac function, and gene expression in congestive heart failure due to myocardial infarction.
Myocardial Infarction
Modification of myosin gene expression by imidapril in failing heart due to myocardial infarction.
Myocardial Infarction
Modification of myosin protein and gene expression in failing hearts due to myocardial infarction by enalapril or losartan.
Myocardial Infarction
Myocardial adaptive changes and damage in ischemic heart disease.
Myocardial Infarction
Protective Effect of Betaine on Changes in the Levels of Membrane-bound ATPase activity and Mineral Status in Experimentally Induced Myocardial Infarction in Wistar Rats.
Myocardial Infarction
Quantitative relationship between global left ventricular thallium uptake and blood flow: effects of propranolol, ouabain, dipyridamole, and coronary artery occlusion.
Myocardial Infarction
Sarcoplasmic reticular Ca2+ pump ATPase activity in congestive heart failure due to myocardial infarction.
Myocardial Infarction
Targeted antioxidant treatment decreases cardiac alternans associated with chronic myocardial infarction.
Myocardial Infarction
[ATPase activity of the heart microsomes, the regulation of calcium transport in the microsomes and the calmodulin content in experimental myocardial infarct]
Myocardial Infarction
[Ca2+-dependent phosphorylation and ATPase activity of cardiac muscle myosin in experimental myocardial infarction]
Myocardial Infarction
[Effect of chemical sympathectomy on ATPase activity and peroxidation of lipids of erythrocyte membrane in rats with myocardial infarction]
Myocardial Infarction
[Effect of riboxine on the ATPase activity and adenine nucleotide content in the myocardium in experimental myocardial infarct]
Myocardial Infarction
[Energy-rich phosphorus compounds, and creatinase and ATPase activity of the heart muscle in experimental myocardial infarction]
Myocardial Infarction
[Peculiarities in the application of the Wachstein and Meisel method for histochemical ATPase demonstration in experimental myocardial infarct]
Myocardial Ischemia
ATPase activity, IF1 content, and proton conductivity of ESMP from control and ischemic slow and fast heart-rate hearts.
Myocardial Ischemia
Cardiogenic endotoxin shock: coronary flow and contractile protein dysfunction as determinants of depressed cardiac contractility.
Myocardial Ischemia
Degradation of the cardiac sarcoplasmic reticulum in acute myocardial ischemia.
Myocardial Ischemia
Electron microscopic studies on the ATPase activity in myocardial infarction -changes in the early myocardial infarction.
Myocardial Ischemia
Endoxin-mediated myocardial ischemia reperfusion injury in rats in vitro.
Myocardial Ischemia
Expression of NTPDase1 and caveolins in human cardiovascular disease.
Myocardial Ischemia
Gastrodin Pretreatment Impact on Sarcoplasmic Reticulum Calcium Transport ATPase (SERCA) and Calcium Phosphate (PLB) Expression in Rats with Myocardial Ischemia Reperfusion.
Myocardial Ischemia
IF1 function in situ in uncoupler-challenged ischemic rabbit, rat, and pigeon hearts.
Myocardial Ischemia
Mitochondrial inner membrane enzyme defects in porcine myocardial ischemia.
Myocardial Ischemia
Ultrastructural changes in the sarcoplasmic reticulum in acute myocardial ischemia.
Myocardial Ischemia
Ultrastructure of the sarcoplasmic reticulum in the ischemic myocardium.
Myocardial Ischemia
[Changes in acetylcholinesterase and ATPase activity and certain structural features of the erythrocyte membrane in experimental myocardial ischemia]
Myocardial Ischemia
[Effect of myocardial ischemia on the ATPase system]
Myocardial Ischemia
[The effect of the alimentary factor on erythrocyte ATPase activity in ischemic heart disease patients]
Myocardial Stunning
C-terminal truncation of cardiac troponin I causes divergent effects on ATPase and force: implications for the pathophysiology of myocardial stunning.
Myocardial Stunning
Effect of global myocardial stunning on Ca2(+)-sensitive myofibrillar ATPase activity and creatine kinase kinetics.
Myocardial Stunning
Effect of myocardial stunning on thiol status, myofibrillar ATPase and troponin I proteolysis.
Myocardial Stunning
Maintained contractile reserve in a transgenic mouse model of myocardial stunning.
Myocardial Stunning
Myocardial stunning is associated with impaired calcium uptake by sarcoplasmic reticulum.
Myocardial Stunning
Sarcoplasmic reticulum in globally stunned adult and newborn myocardium.
Myocardial Stunning
Stunned myocardium has increased mitochondrial NADH oxidase and ATPase activities.
Myocarditis
Investigations of cardiac sarcolemmal ATPase activity in rabbits with acute myocarditis produced by scorpion venom (Buthus tamulus).
Myocarditis
SR-Ca2+ ATPase as an autoimmunogen in experimental myocarditis.
Myocarditis
Ultrastructural study of experimental myocarditis induced by cardiovirus (EMCV-M) in swine.
Myositis
Clinical and histopathological features of myopathies in Japanese patients with anti-SRP autoantibodies.
Myotonia
Erythrocyte ghosts (Na+ + K+) ATPase activity in Duchenne's dystrophy and myotonia.
Myotonia
Sarcoplasmic reticulum ATPase in tibialis anterior muscle from rats with experimental myotonia.
Myotonia
Type 2B muscle fibre deficiency in myotonia and paramyotonia congenita. A genetically determined histochemical fibre type pattern?
Myotonia Congenita
Erythrocyte flexibility, ATPase activities and Ca efflux in patients with Duchenne muscular dystrophy, myotonic muscular dystrophy and congenital myotonia.
Myotonia Congenita
Erythrocyte ghosts (Na+ + K+) ATPase activity in Duchenne's dystrophy and myotonia.
Myotonia Congenita
[Na+ + K+] Mg2+-ATPase of muscle plasma membranes in Duchenne muscular dystrophy.
Myotonic Disorders
Ionic transporting systems of skeletal muscle in relation with innervation and their involvement in myotonic diseases.
Myotonic Dystrophy
Characterization of sarcoplasmic reticulum Ca(2+) ATPase pumps in muscle of patients with myotonic dystrophy and with hypothyroid myopathy.
Myotonic Dystrophy
Erythrocyte ghosts (Na+ + K+) ATPase activity in Duchenne's dystrophy and myotonia.
Myotonic Dystrophy
Erythrocyte membrane abnormalities in human myotonic dystrophy.
Myotonic Dystrophy
Ion transport in human skeletal muscle cells: disturbances in myotonic dystrophy and Brody's disease.
Myotonic Dystrophy
Mechanisms of statin-induced myalgia assessed by physiogenomic associations.
Myotonic Dystrophy
Myotonic dystrophy: fragility of band 3 membrane protein upon resealing of erythrocyte ghosts and the normality of ATPase activity, sialic acid content, and spectrin extractability of ghosts.
Myotonic Dystrophy
[Na+ + K+] Mg2+-ATPase of muscle plasma membranes in Duchenne muscular dystrophy.
Nasopharyngeal Carcinoma
Decreased drug accumulation without increased drug efflux in a novel MRP-overexpressing multidrug-resistant cell line.
Nasopharyngeal Carcinoma
Inhibition of telomerase activity by PKC inhibitors in human nasopharyngeal cancer cells in culture.
Nasopharyngeal Carcinoma
TOP2A overexpression as a poor prognostic factor in patients with nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Topoisomerase IIa deregulation in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
[Experimental studies on treatment of nasopharyngeal carcinoma with combination regimen of hydroxycamptothecin and etoposide]
Nasopharyngeal Carcinoma
[Expression of topoisomerase IIalpha in nasopharyngeal carcinoma and its clinical significance]
Neoplasm Metastasis
Amplification of HER-2/neu and topoisomerase IIalpha in primary and metastatic breast cancer.
Neoplasm Metastasis
Antimetastatic Activities and Mechanisms of Bisdioxopiperazine Compounds.
Neoplasm Metastasis
ATAD2 expression increases [18F]Fluorodeoxyglucose uptake value in lung adenocarcinoma via AKT-GLUT1/HK2 pathway.
Neoplasm Metastasis
ATAD2 overexpression is associated with progression and prognosis in colorectal cancer.
Neoplasm Metastasis
Bioinformatics analysis identified hub genes in prostate cancer tumorigenesis and metastasis.
Neoplasm Metastasis
Comparison of topoisomerase-IIalpha gene status between primary breast cancer and corresponding distant metastatic sites.
Neoplasm Metastasis
Correlations of ICAM-1 gene polymorphisms with susceptibility and multidrug resistance in colorectal cancer in a Chinese population.
Neoplasm Metastasis
CORRELATIONSHIP OF CATHEPSIN D AND TOPOISOMERASE II ALPHA WITH NUCLEAR GRADING IN BREAST CANCERS.
Neoplasm Metastasis
DNA topoisomerase II alpha and Ki-67 in human adrenocortical neoplasms: a possible marker of differentiation between adenomas and carcinomas.
Neoplasm Metastasis
DNA Topoisomerase II-alpha as a marker of cell proliferation in endocrine and other neoplasms.
Neoplasm Metastasis
DNA topoisomerase II-alpha as a proliferation marker in human gliomas: correlation with PCNA expression and patient survival.
Neoplasm Metastasis
Effect of LINAC radiosurgery on regional cerebral blood flow, glucose metabolism and sodium-potassium AtPase in skull base meningiomas and metastasis.
Neoplasm Metastasis
ER, HER2, and TOP2A expression in primary tumor, synchronous axillary nodes, and asynchronous metastases in breast cancer.
Neoplasm Metastasis
Expression Patterns of Biomarkers in Primary Tumors and Corresponding Metastases in Breast Cancer.
Neoplasm Metastasis
Extensive analysis of the molecular biomarkers excision repair cross complementing 1, ribonucleotide reductase M1, ?-tubulin III, thymidylate synthetase, and topoisomerase II? in breast cancer: Association with clinicopathological characteristics.
Neoplasm Metastasis
Gene expression profiles in cells transformed by overexpression of the IGF-I receptor.
Neoplasm Metastasis
HER2 and TOP2A Gene Amplification and Protein Expression in Upper Tract Urothelial Carcinomas.
Neoplasm Metastasis
High expression of TOP2A in hepatocellular carcinoma is associated with disease progression and poor prognosis.
Neoplasm Metastasis
Histone Deacetylase Inhibitor Treatment Increases the Expression of the Plasma Membrane Ca(2+) Pump PMCA4b and Inhibits the Migration of Melanoma Cells Independent of ERK.
Neoplasm Metastasis
ICRF-187 rescue in etoposide treatment in vivo. A model targeting high-dose topoisomerase II poisons to CNS tumors.
Neoplasm Metastasis
Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation.
Neoplasm Metastasis
Joint detection of multiple immunohistochemical indices and clinical significance in breast cancer.
Neoplasm Metastasis
Knockdown of OLA1, a regulator of oxidative stress response, inhibits motility and invasion of breast cancer cells.
Neoplasm Metastasis
LASS2 inhibits growth and invasion of bladder cancer by regulating ATPase activity.
Neoplasm Metastasis
Long non?coding RNA?DUXAP8 regulates TOP2A in the growth and metastasis of osteosarcoma via microRNA?635.
Neoplasm Metastasis
MicroRNAs associated with lung squamous cell carcinoma: New prognostic biomarkers and therapeutic targets.
Neoplasm Metastasis
MiRNA-145-5p expression and prospective molecular mechanisms in the metastasis of prostate cancer.
Neoplasm Metastasis
Multi-Omics Characterization of the 4T1 Murine Mammary Gland Tumor Model.
Neoplasm Metastasis
Multidrug resistance protein and topoisomerase 2 alpha expression in non-small cell lung cancer are related with brain metastasis postoperatively.
Neoplasm Metastasis
New prognostic markers revealed by evaluation of genes correlated with clinical parameters in Wilms tumors.
Neoplasm Metastasis
Obg-like ATPase 1 inhibited oral carcinoma cell metastasis through TGF?/SMAD2 axis in vitro.
Neoplasm Metastasis
P-Gp and TOPO II Expression and Their Clinical Significance in Colon Cancer.
Neoplasm Metastasis
Plasma membrane calcium ATPase expression in human colon multistep carcinogenesis.
Neoplasm Metastasis
Pleiotropic over-expression of multidrug-resistance-related genes is correlated to MYCN and max mRNA accumulation during tumour progression in the IGR-N-91 human neuroblastoma model.
Neoplasm Metastasis
Polyketides from the marine-derived fungus Aspergillus falconensis: In silico and in vitro cytotoxicity studies.
Neoplasm Metastasis
Potential role for the Metnase transposase fusion gene in colon cancer through the regulation of key genes.
Neoplasm Metastasis
Prognostic value of FHIT, CTNNB1, and MUC1 expression in non-small cell lung cancer.
Neoplasm Metastasis
Prognostic value of proliferation in pleomorphic soft tissue sarcomas: a new look at an old measure.
Neoplasm Metastasis
Prognostic value of Topoisomerase II in female breast cancer.
Neoplasm Metastasis
Quantitative protein expression of blood-brain barrier transporters in the vasculature of brain metastases of patients with lung and breast cancer.
Neoplasm Metastasis
Reciprocal activation between ATPase inhibitory factor 1 and NF-?B drives hepatocellular carcinoma angiogenesis and metastasis.
Neoplasm Metastasis
Silencing of LASS2/TMSG1 enhances invasion and metastasis capacity of prostate cancer cell.
Neoplasm Metastasis
The Inhibition of miR-144-3p on Cell Proliferation and Metastasis by Targeting TOP2A in HCMV-Positive Glioblastoma Cells.
Neoplasm Metastasis
The prognostic significance of topoisomerase II alpha protein in early stage luminal breast cancer.
Neoplasm Metastasis
The role of the cancer stem cell marker CD271 in DNA damage response and drug resistance of melanoma cells.
Neoplasm Metastasis
Therapeutic effect of pirarubicin-based chemotherapy for osteosarcoma patients with lung metastasis.
Neoplasm Metastasis
TOP2A induces malignant character of pancreatic cancer through activating ?-catenin signaling pathway.
Neoplasm Metastasis
TOP2A overexpression as a poor prognostic factor in patients with nasopharyngeal carcinoma.
Neoplasm Metastasis
TOP2A Promotes Lung Adenocarcinoma Cells' Malignant Progression and Predicts Poor Prognosis in Lung Adenocarcinoma.
Neoplasm Metastasis
Topoisomerase II alpha expression in breast ductal invasive carcinomas and correlation with clinicopathological variables.
Neoplasm Metastasis
Topoisomerase II alpha expression in esophageal squamous cell carcinoma.
Neoplasm Metastasis
Topoisomerase II alpha promotes gallbladder cancer proliferation and metastasis through activating phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway.
Neoplasm Metastasis
Topoisomerase II alpha--a fundamental prognostic factor in breast carcinoma.
Neoplasm Metastasis
Topoisomerase IIalpha expression in breast cancer: correlation with outcome variables.
Neoplasm Metastasis
Topoisomerase IIalpha expression in pituitary adenomas and carcinomas: relationship to tumor behavior.
Neoplasm Metastasis
Topoisomerase IIalpha in Wilms' tumour: gene alterations and immunoexpression.
Neoplasm Metastasis
Vacuolar H+ ATPase expression and activity is required for Rab27B-dependent invasive growth and metastasis of breast cancer.
Neoplasm Metastasis
[Comparative study of Coptidis Rhizoma and Aconiti Kusnezoffii Radix on cell differentiation in lewis lung cancer].
Neoplasm Metastasis
[Correlation between aneuploidy of chromosome 17, over-expression of TP53 and TOPIIalpha, and the clinicopathological features and diagnosis of gastric adenocarcinoma]
Neoplasm Metastasis
[Efficacy of hepatic arterial infusion of adriamycin and mitomycin C mixed with degradable starch microspheres for liver metastasis of colorectal cancer--correlation with the mRNA expression of DNA topoisomerase-IIalpha and glutathione-S transferase-pi in primary lesions]
Neoplasm Metastasis
[Expression and significance of P-glycoprotein, glutathione S-transferase-pi and Topoisomerase II in gastric carcinomas]
Neoplasm Metastasis
[Expression of glutathione S-transferase-pi and DNA topoisomerase II alpha and their implications in colorectal carcinoma]
Neoplasm Metastasis
[Expression of topoisomerase II alpha in human colorectal carcinoma and its significance.]
Neoplasm Metastasis
[Expression of topoisomerase IIalpha in nasopharyngeal carcinoma and its clinical significance]
Neoplasm Metastasis
[The expression of ki-67, topoIIalpha in laryngeal squamous cell carcinoma]
Neoplasm, Residual
Prognostic significance of CD3+ tumor-infiltrating lymphocytes in ovarian carcinoma.
Neoplasms
(S)-Erypoegin K, an isoflavone isolated from Erythrina poeppigiana, is a novel inhibitor of topoisomerase II?: Induction of G2 phase arrest in human gastric cancer cells.
Neoplasms
1,25-Dihydroxyvitamin D3 enhances the susceptibility of breast cancer cells to doxorubicin-induced oxidative damage.
Neoplasms
10,11-Methylenedioxycamptothecin, a topoisomerase I inhibitor of increased potency: DNA damage and correlation to cytotoxicity in human colon carcinoma (HT-29) cells.
Neoplasms
2-APCAs, the Novel Microtubule Targeting Agents Active Against Distinct Cancer Cell Lines.
Neoplasms
2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy]-propionic acid (XK469) inhibition of topoisomerase IIbeta is not sufficient for therapeutic response in human Waldenstrom's macroglobulinemia xenograft model.
Neoplasms
2-[4-(7-chloro-2-quinoxalinyloxyphenoxy]-propionic acid (XK469), an inhibitor of topoisomerase (Topo) IIbeta, up-regulates Topo IIalpha and enhances Topo IIalpha-mediated cytotoxicity.
Neoplasms
3-(Dipropylamino)-5-hydroxybenzofuro[2,3-f]quinazolin-1(2H)-one (DPA-HBFQ-1) plays an inhibitory role on breast cancer cell growth and progression.
Neoplasms
31P nuclear magnetic resonance measurements of ATPase kinetics in malignant tumors.
Neoplasms
332?Molecular Characteristics of Tumor Infiltrating Front in Glioblastoma: Insights Into Molecular Heterogeneity and Implications on Targeted Therapy.
Neoplasms
5k, a novel beta-O-demethyl-epipodophyllotoxin analogue, inhibits the proliferation of cancer cells in vitro and in vivo via the induction of G2 arrest and apoptosis.
Neoplasms
64Cu-azabicyclo[3.2.2]nonane thiosemicarbazone complexes: radiopharmaceuticals for PET of topoisomerase II expression in tumors.
Neoplasms
9-Amino acridine pharmacokinetics, brain distribution, and in vitro/in vivo efficacy against malignant glioma.
Neoplasms
9-Bromo-2,3-diethylbenzo[de]chromene-7,8-dione (MSN54): A novel non-intercalative topoisomerase II catalytic inhibitor.
Neoplasms
?9-THC increases endogenous AHA1 expression in rat cerebellum and may modulate CB1 receptor function during chronic use.
Neoplasms
?III-tubulin overexpression is linked to aggressive tumor features and genetic instability in urinary bladder cancer.
Neoplasms
A "Double-Edged" Scaffold: Antitumor Power within the Antibacterial Quinolone.
Neoplasms
A 3-gene proliferation score (TOP-FOX-67) can re-classify histological grade-2, ER-positive breast cancers into low- and high-risk prognostic categories.
Neoplasms
A benzophenazine derivative, N-beta-dimethylaminoethyl 9-carboxy-5-hydroxy-10-methoxy-benzo[a]phenazine-6-carboxamide, as a new antitumor agent against multidrug-resistant and sensitive tumors.
Neoplasms
A bufadienolide derived androgen receptor antagonist with inhibitory activities against prostate cancer cells.
Neoplasms
A case of gastric-type adenoma with chief cell and parietal cell differentiation surrounded by complete intestinal metaplasia.
Neoplasms
A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin.
Neoplasms
A critical role of interleukin-10 in the response of bovine macrophages to infection by Mycobacterium avium subsp paratuberculosis.
Neoplasms
A diagnostic tool for monitoring multidrug resistance expression in human tumor tissues.
Neoplasms
A dual topoisomerase inhibitor, TAS-103, induces apoptosis in human cancer cells.
Neoplasms
A general characteristic of tumor mitochondria: leakage of endogenous Mg2+ on incubation with uncoupler and resultant reduction of uncoupler-stimulated ATPase activity.
Neoplasms
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors.
Neoplasms
A homeopathic nosode, Hepatitis C 30 demonstrates anticancer effect against liver cancer cells in vitro by modulating telomerase and topoisomerase II activities as also by promoting apoptosis via intrinsic mitochondrial pathway.
Neoplasms
A lack of detectable modification of topoisomerase II activity in a series of human tumor cell lines expressing only low levels of etoposide resistance.
Neoplasms
A molecular 'signature' of primary breast cancer cultures; patterns resembling tumor tissue.
Neoplasms
A molecular classification of papillary renal cell carcinoma.
Neoplasms
A new class of naphthalimide-based antitumor agents that inhibit topoisomerase II and induce lysosomal membrane permeabilization and apoptosis.
Neoplasms
A new generation of MDR modulating agents with dual activity: P-gp inhibitor and iNOS inducer agents.
Neoplasms
A new topoisomerase II inhibitor, BE-22179, produced by a streptomycete. I. Producing strain, fermentation, isolation and biological activity.
Neoplasms
A novel carbazole topoisomerase II poison, ER-37328: potent tumoricidal activity against human solid tumors in vitro and in vivo.
Neoplasms
A novel class of tubulin inhibitors that exhibit potent antiproliferation and in vitro vessel-disrupting activity.
Neoplasms
A novel homogenous assay for topoisomerase II action and inhibition.
Neoplasms
A novel Hsp70 inhibitor specifically targeting the cancer-related Hsp70-Bim protein-protein interaction.
Neoplasms
A novel ligand in lymphocyte-mediated cytotoxicity: expression of the beta subunit of H+ transporting ATP synthase on the surface of tumor cell lines.
Neoplasms
A novel peroxisome proliferator-activated receptor alpha/gamma agonist, BPR1H0101, inhibits topoisomerase II catalytic activity in human cancer cells.
Neoplasms
A Novel Synthetic Dihydroindeno[1,2-b] Indole Derivative (LS-2-3j) Reverses ABCB1- and ABCG2-Mediated Multidrug Resistance in Cancer Cells.
Neoplasms
A novel topoisomerase inhibitor, daurinol, suppresses growth of HCT116 cells with low hematological toxicity compared to etoposide.
Neoplasms
A peptide fraction from germinated soybean protein down-regulates PTTG1 and TOP2A mRNA expression, inducing apoptosis in cervical cancer cells.
Neoplasms
A phase 1 open-label, accelerated dose-escalation study of the hypoxia-activated prodrug AQ4N in patients with advanced malignancies.
Neoplasms
A phase I and translational study of sequential administration of the topoisomerase I and II inhibitors topotecan and etoposide.
Neoplasms
A phase I study of topotecan followed sequentially by doxorubicin in patients with advanced malignancies.
Neoplasms
A phase II study of Epirubicin in oxaliplatin-resistant patients with metastatic colorectal cancer and TOP2A gene amplification.
Neoplasms
A phase II study of razoxane, an antiangiogenic topoisomerase II inhibitor, in renal cell cancer with assessment of potential surrogate markers of angiogenesis.
Neoplasms
A phase II trial of ganetespib, a heat shock protein 90 Hsp90) inhibitor, in patients with docetaxel-pretreated metastatic castrate-resistant prostate cancer (CRPC)-a prostate cancer clinical trials consortium (PCCTC) study.
Neoplasms
A phytochemical investigation of Alchornea latifolia.
Neoplasms
A protein factor from Xenopus oocytes with simian virus 40 large tumor antigen-like DNA supercoiling activity.
Neoplasms
A proteomic approach to identifying new drug targets (potentiating topoisomerase II poisons).
Neoplasms
A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication.
Neoplasms
A selective and sensitive stability-Indicating HPLC method for the validated assay of etoposide from commercial dosage form and polymeric tubular nanocarriers.
Neoplasms
A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity.
Neoplasms
A small molecule inhibitor of ATPase activity of HSP70 induces apoptosis and has antitumor activities.
Neoplasms
A study of proliferative markers and tumor suppressor gene proteins in different grades of ependymomas.
Neoplasms
A study of the expression of four chemoresistance-related genes in human primary and metastatic brain tumours.
Neoplasms
A three-dimensional quantitative structure-activity relationship study of the inhibition of the ATPase activity and the strand passing catalytic activity of topoisomerase IIalpha by substituted purine analogs.
Neoplasms
A TOP2A-derived cancer panel drives cancer progression in papillary renal cell carcinoma.
Neoplasms
A topoisomerase II inhibitor, NK109, induces DNA single- and double-strand breaks and apoptosis.
Neoplasms
A topoisomerase II poison screen of ethnomedicinal Thai plants using a yeast cell-based assay.
Neoplasms
A two-drug model for etoposide action against human topoisomerase IIalpha.
Neoplasms
A type-II DNA topoisomerase and a catenating protein from the transplantable VX2 carcinoma.
Neoplasms
A unifying model of the cell proliferation emphasizing plasma membrane fluxes.
Neoplasms
ABCG2 (breast cancer resistance protein/mitoxantrone resistance-associated protein) ATPase assay: a useful tool to detect drug-transporter interactions.
Neoplasms
Aberrant DNA topoisomerase II activity, radioresistance and inherited susceptibility to cancer.
Neoplasms
Aberrations of ERBB2 and TOP2A genes in breast cancer.
Neoplasms
Accumulation of radioisotopes with tumor affinity. II. Comparison of the tumor accumulation of 67Ga-citrate and 201Tl-chloride in vitro.
Neoplasms
Acidic pH induces topoisomerase II-mediated DNA damage.
Neoplasms
Action of the antitumor and antispermatogenic agent lonidamine on electron transport in Ehrlich ascites tumor mitochondria.
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Activated cofilin colocalises with Arp2/3 complex in apoptotic blebs during programmed cell death.
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Activation of ATM and Histone H2AX Phosphorylation Induced by Mitoxantrone But Not by Topotecan is Prevented by the Antioxidant N-acetyl-L-Cysteine.
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Activation of clinically used anthracyclines by the formaldehyde-releasing prodrug pivaloyloxymethyl butyrate.
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Activity of M3814, an Oral DNA-PK Inhibitor, In Combination with Topoisomerase II Inhibitors in Ovarian Cancer Models.
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Activity of NK 611, a new epipodophyllotoxin derivative, against colony forming units from freshly explanted human tumours in vitro.
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Activity of the polyamine-vectorized anti-cancer drug F14512 against pediatric glioma and neuroblastoma cell lines.
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Acute myeloid leukemia as a second malignancy: report of 9 pediatric patients in a single institution in Argentina.
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Additive effect of adenovirus-mediated E2F-1 gene transfer and topoisomerase II inhibitors on apoptosis in human osteosarcoma cells.
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Adenosine triphosphatase activity of crystalline inclusions in alveolar soft part sarcoma. An ultrahistochemical study of a case.
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Adenovirus-mediated human topoisomerase IIalpha gene transfer increases the sensitivity of etoposide-resistant human and mouse breast cancer cells.
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Adenovirus-mediated human topoisomerase IIalpha gene transfer increases the sensitivity of etoposide-resistant human breast cancer cells.
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Adjuvant chemotherapy in early breast cancer.
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Advanced nanoscale carrier-based approaches to overcome biopharmaceutical issues associated with anticancer drug 'Etoposide'.
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Aggressive silent corticotroph adenoma progressing to pituitary carcinoma: the role of temozolomide therapy.
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ALL-1 gene rearrangements in DNA topoisomerase II inhibitor-related leukemia in children.
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ALL-1/MLL1, a homologue of Drosophila TRITHORAX, modifies chromatin and is directly involved in infant acute leukaemia.
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alpha-Methylacyl coenzyme A racemase, Ki-67, and topoisomerase IIalpha in cystoprostatectomies with incidental prostate cancer.
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Alteration of topoisomerase II-alpha gene in human breast cancer: association with responsiveness to anthracycline-based chemotherapy.
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Alterations in the TOP2A and HER2 genes: association with adjuvant anthracycline sensitivity in human breast cancers.
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Altered expression of resistance associated genes in hepatoblastoma xenografts incorporated into mice following treatment with adriamycin or cisplatin.
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Altered Expression Pattern of Topoisomerase IIalpha in Ovarian Tumor Epithelial and Stromal Cells after Platinum-Based Chemotherapy.
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Altered topoisomerase IIalpha and multidrug resistance-associated protein levels during drug selection: adaptations to increasing drug pressure.
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Ameliorative effect of ferruginol on isoprenaline hydrochloride-induced myocardial infarction in rats.
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Ammonium tetrathiomolybdate enhances the antitumor effect of cisplatin via the suppression of ATPase copper transporting beta in head and neck squamous cell carcinoma.
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Amplicons in breast cancers analyzed by multiplex ligation-dependent probe amplification and fluorescence In Situ hybridization.
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Amplification and deletion of topoisomerase IIalpha associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer.
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Amplification and overexpression of topoisomerase IIalpha predict response to anthracycline-based therapy in locally advanced breast cancer.
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Amplification of ERBB2, RARA, and TOP2A genes in a myelodysplastic syndrome transforming to acute myeloid leukemia.
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Amplification of HER-2 in gastric carcinoma: association with Topoisomerase IIalpha gene amplification, intestinal type, poor prognosis and sensitivity to trastuzumab.
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Amplification of HER-2/neu and topoisomerase IIalpha in primary and metastatic breast cancer.
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Amplification of HER2 and TOP2A and deletion of TOP2A genes in a series of Taiwanese breast cancer.
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Amplification of HER2 and TOP2A and deletion of TOP2A genes in breast cancer investigated by new FISH probes.
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Amplification of the TOP2A gene does not predict high levels of topoisomerase II alpha protein in human breast tumor samples.
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Amplification of the topoisomerase II alpha gene in a non-small cell lung cancer cell line and characterisation of polymorphisms at the human topoisomerase II alpha and beta loci in normal tissue.
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Amplification of TOP2A and HER-2 genes in breast cancers occurring in patients harbouring BRCA1 germline mutations.
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Amsacrine-induced lesions in DNA and their modulation by novobiocin and 2,4-dinitrophenol.
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An efficient one-pot synthesis of benzothiazolo-4?-anilino-podophyllotoxin congeners: DNA topoisomerase-II inhibition and anticancer activity.
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An Integrated Drosophila Model System Reveals Unique Properties for F14512, a Novel Polyamine-Containing Anticancer Drug That Targets Topoisomerase II.
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An Msh3 ATPase domain mutation has no effect on MMR function.
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Analysis of bisdioxopiperazine dexrazoxane binding to human DNA topoisomerase II alpha: decreased binding as a mechanism of drug resistance.
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Analysis of EGFR, HER2, and TOP2A gene status and chromosomal polysomy in gastric adenocarcinoma from Chinese patients.
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Analysis of ERBB2 and TOP2A gene status using fluorescence in situ hybridization versus immunohistochemistry in localized breast cancer.
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Analysis of inhibition of topoisomerase IIalpha and cancer cell proliferation by ingenolEZ.
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Analysis of type of cell death induced by topoisomerase inhibitor SN-38 in human oral squamous cell carcinoma cell lines.
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Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements.
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Angiogenesis determines blood flow, metabolism, growth rate, and ATPase kinetics of tumors growing in an irradiated bed: 31P and 2H nuclear magnetic resonance studies.
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Anthracycline-induced cardiotoxicity: A case report and review of literature.
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Anti-tumour activities of a new benzo[c]phenanthridine agent, 2,3-(methylenedioxy)-5-methyl-7-hydroxy-8-methoxybenzo[c]phena nthridini um hydrogensulphate dihydrate (NK109), against several drug-resistant human tumour cell lines.
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Antiangiogenic and antitumoral activity of phenyl-3-(2-chloroethyl)ureas: a class of soft alkylating agents disrupting microtubules that are unaffected by cell adhesion-mediated drug resistance.
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Anticancer Activity and Topoisomerase II Inhibition of Naphthalimides with ?-Hydroxylalkylamine Side-Chains of Different Lengths.
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Antimetastatic Activities and Mechanisms of Bisdioxopiperazine Compounds.
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Antiproliferative prostaglandins and the MRP/GS-X pump role in cancer immunosuppression and insight into new strategies in cancer gene therapy.
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Antisense inhibition of P-glycoprotein expression using peptide-oligonucleotide conjugates.
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Antitumor activity of ER-37328, a novel carbazole topoisomerase II inhibitor.
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Antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga.
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Antitumor activity of XR5944, a novel and potent topoisomerase poison.
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Antitumor agents. 194. Synthesis and biological evaluations of 4-beta-mono-, -di-, and -trisubstituted aniline-4'-O-demethyl-podophyllotoxin and related compounds with improved pharmacological profiles.
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Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4beta-[(4' '-benzamido)-amino]-4'-o-demethyl-epipodophyllotoxin derivatives.
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Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents.
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Apoptosis and cancer chemotherapy.
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Apoptosis is the most efficient death-pathway in tumor cells after topoisomerase II inhibition.
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Apoptotic and proliferative activity in ovarian benign, borderline and malignant tumors.
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Appearance of aberrant mitosis in murine leukemia cells upon combined treatment with low concentrations of cisplatin and teniposide.
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Application of Albumin-embedded Magnetic Nanoheaters for Release of Etoposide in Integrated Chemotherapy and Hyperthermia of U87-MG Glioma Cells.
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Application of mRNA regulatory regions to improve tumor specificity of transgene expression.
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Application of topoisomerase assays in the evaluation of natural products as antitumor agents.
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AQP5 silencing suppresses p38 MAPK signaling and improves drug resistance in colon cancer cells.
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Are topoisomerase II inhibitor-induced micronuclei in vitro a predictive marker for the compounds' ability to cause secondary leukemias after treatment?
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Assays to predict the genotoxicity of the chromosomal mutagen etoposide -- focussing on the best assay.
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Assessment of cell proliferation in renal cell carcinoma using dual-phase (18)F-fluorodeoxyglucose PET/CT.
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Assessment of drug-induced dysregulations among seven resistance-associated genes in human tumour cell lines.
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Assessment of Topoisomerase II ? Status in Breast Cancer by Quantitative PCR, Gene Expression Microarrays, Immunohistochemistry, and Fluorescence in Situ Hybridization.
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Association between HER2, TOP2A, and response to anthracycline-based preoperative chemotherapy in high-risk primary breast cancer.
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Association between p53 expression and Bcl-2, P-glycoprotein, topoisomerase II alpha, thymidylate synthase and thymidine phosphorylase as potential therapeutic targets in colorectal cancer patients.
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Association of low tumor RNA integrity with response to chemotherapy in breast cancer patients.
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Association of Topoisomerase II (TOP2A) and Dual-Specificity Phosphatase 6 (DUSP6) Single Nucleotide Polymorphisms with Radiation Treatment Response and Prognosis of Lung Cancer in Han Chinese.
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ATAD2 expression increases [18F]Fluorodeoxyglucose uptake value in lung adenocarcinoma via AKT-GLUT1/HK2 pathway.
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ATAD2 is overexpressed in gastric cancer and serves as an independent poor prognostic biomarker.
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ATAD2 overexpression is associated with progression and prognosis in colorectal cancer.
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ATAD2 predicts poor outcomes in patients with ovarian cancer and is a marker of proliferation.
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ATAD2 silencing decreases VEGFA secretion through targeting has-miR-520a to inhibit angiogenesis in colorectal cancer.
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ATM deficiency is associated with sensitivity to PARP1 and ATR inhibitors in lung adenocarcinoma.
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ATPase activity of P-glycoprotein related to emergence of drug resistance in Ehrlich ascites tumor cell lines.
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ATPase inhibitory factor 1 expression is an independent prognostic factor in non-small cell lung cancer.
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ATPase inhibitory factor 1 is a prognostic marker and contributes to proliferation and invasion of human gastric cancer cells.
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Author Correction: EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors.
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Autoantibody to DNA topoisomerase II in primary liver cancer
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Autocrine Adenosine regulates tumor polyfunctional CD73+CD4+ effector T cells devoid of immune checkpoints.
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Autotaxin (lysoPLD/NPP2) protects fibroblasts from apoptosis through its enzymatic product, lysophosphatidic acid, utilizing albumin-bound substrate.
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Azatoxin derivatives with potent and selective action on topoisomerase II.
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B1, a novel topoisomerase II inhibitor, induces apoptosis and cell cycle G1 arrest in lung adenocarcinoma A549 cells.
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Bactericidal activity of alveolar macrophages is suppressed by V-ATPase inhibition.
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BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.
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BAF complexes facilitate decatenation of DNA by topoisomerase II?.
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Barbigerone reverses multidrug resistance in breast MCF-7/ADR cells.
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bcl-2 protein inhibits etoposide-induced apoptosis through its effects on events subsequent to topoisomerase II-induced DNA strand breaks and their repair.
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Becatecarin (Helsinn Healthcare).
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Binding of anticancer drug adriamycin to parallel G-quadruplex DNA [d-(TTAGGGT)]4 comprising human telomeric DNA leads to thermal stabilization: A multiple spectroscopy study.
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Binding of etoposide to topoisomerase II in the absence of DNA: decreased affinity as a mechanism of drug resistance.
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Bioassay-Guided Isolation of Two Flavonoids from Derris scandens with Topoisomerase II Poison Activity.
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Biochemical modulation of cytotoxic drugs by cytokines: molecular mechanisms in experimental oncology.
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Bioinformatics analysis shows that TOP2A functions as a key candidate gene in the progression of cervical cancer.
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Bipartite nuclear localization signals in the C terminus of human topoisomerase II alpha.
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BIRICODAR (VX-710; Incel): an effective chemosensitizer in neuroblastoma.
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BN 80927: a novel homocamptothecin with inhibitory activities on both topoisomerase I and topoisomerase II.
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Breast cancer after mantle irradiation for Hodgkin's disease: correlation of clinical, pathologic, and molecular features including loss of heterozygosity at BRCA1 and BRCA2.
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BRG1 mutations found in human cancer cell lines inactivate Rb-mediated cell cycle arrest.
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BRG1 mutations found in human cancer cell lines inactivate Rb-mediated cell-cycle arrest.
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BRM: the core ATPase subunit of SWI/SNF chromatin-remodelling complex-a tumour suppressor or tumour-promoting factor?
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c-erbB2 and topoisomerase IIalpha protein expression independently predict poor survival in primary human breast cancer: a retrospective study.
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c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function.
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C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.
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Calcium transport by plasma membranes from a glucose-responsive rat insulinoma.
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Cancer cell adaptation to chemotherapy.
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Cancer Resistance to Type II Topoisomerase Inhibitors.
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Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors.
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Cancer therapy shapes the fitness landscape of clonal hematopoiesis.
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Candidate biomarkers predictive of anthracycline and taxane efficacy against breast cancer.
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Cardiac glycosides in cancer research and cancer therapy.
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Catalytic Inhibition of Human DNA Topoisomerase II by Interactions of Grape Cell Culture Polyphenols.
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Catalytic inhibition of topoisomerase II by a novel rationally designed ATP-competitive purine analogue.
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Catalytic inhibitors of DNA topoisomerase II suppress the androgen receptor signaling and prostate cancer progression.
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Catalytic inhibitors of topoisomerase II differently modulate the toxicity of anthracyclines in cardiac and cancer cells.
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Catalytic topoisomerase II inhibitors in cancer therapy.
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CB-6644 Is a Selective Inhibitor of the RUVBL1/2 Complex with Anticancer Activity.
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CD26/dipeptidyl peptidase IV as a novel therapeutic target for cancer and immune disorders.
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CEF is superior to CMF for tumours with TOP2A aberrations: a Subpopulation Treatment Effect Pattern Plot (STEPP) analysis on Danish Breast Cancer Cooperative Group Study 89D.
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Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells.
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Cellular proliferative fraction measured with topoisomerase IIalpha predicts malignancy in endocrine pancreatic tumors.
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Cellular resistance to the antitumor DNA topoisomerase II inhibitor S16020-2: importance of the N-[2(Dimethylamino)ethyl]carbamoyl side chain.
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Cellular responses to methyl-N-[4-9-acridinylamino)-2-methoxyphenyl] carbamate hydrochloride, an analogue of amsacrine active against non-proliferating cells.
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cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.
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Changes in membrane microdomains and caveolae constituents in multidrug-resistant cancer cells.
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Changes in subcellular distribution of topoisomerase IIalpha correlate with etoposide resistance in multicell spheroids and xenograft tumors.
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Changes in WT1 splicing are associated with a specific gene expression profile in Wilms' tumour.
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Changes of Topoisomerase II{alpha} Expression in Breast Tumors after Neoadjuvant Chemotherapy Predicts Relapse-Free Survival.
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Changing picture of cellular drug resistance in human leukemia.
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Characteristic sequence motifs located at the genomic breakpoints of the translocation t(X;18) in synovial sarcomas.
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Characteristics of adenine nucleotide fluxes and transport in human tumor mitochondria.
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Characterization of a DNA topoisomerase IIalpha gene rearrangement in adriamycin-resistant P388 leukemia: expression of a fusion messenger RNA transcript encoding topoisomerase IIalpha and the retinoic acid receptor alpha locus.
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Characterization of cellular accumulation and toxicity of illudin S in sensitive and nonsensitive tumor cells.
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Characterization of genomic breakpoints in MLL and CBP in leukemia patients with t(11;16).
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Characterization of human NSCLC cell line with innate etoposide-resistance mediated by cytoplasmic localization of topoisomerase II alpha.
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Characterization of salvicine-resistant lung adenocarcinoma A549/SAL cell line.
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Characterization of the human topoisomerase IIbeta (TOP2B) promoter activity: essential roles of the nuclear factor-Y (NF-Y)- and specificity protein-1 (Sp1)-binding sites.
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Characterization of therapy-related acute leukemia in hereditary breast-ovarian carcinoma patients: role of BRCA1 mutation and topoisomerase II-directed therapy.
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Characterization of topoisomerase II ? and minichromosome maintenance protein 2 expression in anal carcinoma.
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Characterization of topoisomerase II alpha gene amplification and deletion in breast cancer.
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Chemopreventive effect of piperine on modulating lipid peroxidation and membrane bound enzymes in benzo(a)pyrene induced lung carcinogenesis.
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Chemopreventive Potential of Flavonoid Extracts from Plantation-Bred and Wild Aronia melanocarpa (Black Chokeberry) Fruits
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Chiral high-performance liquid chromatographic analysis of the enantiomers of XK469, a new antitumor agent, in plasma and urine.
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Chiral pharmacokinetics and inversion of enantiomers of a new quinoxaline topoisomerase IIbeta poison in the rat.
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Chromatin remodelling at the topoisomerase II-beta promoter is associated with enhanced sensitivity to etoposide in human neuroblastoma cell lines.
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Chromatin-remodeling complex SWI/SNF controls multidrug resistance by transcriptionally regulating the drug efflux pump ABCB1.
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Chromosome 17 centromere duplication and responsiveness to anthracycline-based neoadjuvant chemotherapy in breast cancer.
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Ciprofloxacin as a prophylactic agent against prostate cancer: a "two hit" hypothesis.
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Ciprofloxacin-induced G(2) arrest and apoptosis in TK6 lymphoblastoid cells is not dependent on DNA double-strand break formation.
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Cisplatin-induced endoreduplication in CHO cells: DNA damage and inhibition of topoisomerase II.
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Claudin-4, mitogen-activated protein kinase kinase 4, and stratifin are markers of gastric adenocarcinoma precursor lesions.
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Cleavage of Plasmid DNA by Eukaryotic Topoisomerase II.
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Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94.
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Clinical and Steroidogenic Characteristics of Aldosterone-Producing Adenomas With ATPase or CACNA1D Gene Mutations.
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Clinical applications of anticancer drugs targeted to topoisomerase II.
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Clinical characterization for proliferation and metastasis in advanced hepatocellular carcinoma patients.
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Clinical evaluation of developed PCR-based method with hydrolysis probes for TOP2A copy number evaluation in breast cancer samples.
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Clinical resistance to topoisomerase-targeted drugs.
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Clinical significance of P-class pumps in cancer.
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Clinical significance of the increased multidrug resistance-associated protein (MRP) gene expression in patients with primary breast cancer.
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Clinical significance of topoisomerase-II expression in patients with advanced non-small cell lung cancer treated with amrubicin.
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Clinicopathological significance of human apurinic/apyrimidinic endonuclease 1 (APE1) expression in oestrogen-receptor-positive breast cancer.
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Clinicopathological Significance of the Proliferation Markers Ki67, RacGAP1, and Topoisomerase 2 Alpha in Breast Cancer.
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Co-amplification of erbB2, topoisomerase II alpha and retinoic acid receptor alpha genes in breast cancer and allelic loss at topoisomerase I on chromosome 20.
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Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole hsp90 inhibitors.
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Colorectal carcinomas with high microsatellite instability: defining a distinct immunologic and molecular entity with respect to prognostic markers.
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Combination phenylbutyrate/gemcitabine therapy effectively inhibits in vitro and in vivo growth of NSCLC by intrinsic apoptotic pathways.
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Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90.
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Combined treatment with temozolomide and methoxyamine: blocking apurininc/pyrimidinic site repair coupled with targeting topoisomerase IIalpha.
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Comparative evaluation of three proliferation markers, Ki-67, TOP2A, and RacGAP1, in bronchopulmonary neuroendocrine neoplasms: Issues and prospects.
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Comparative value of tumour grade, hormonal receptors, Ki-67, HER-2 and topoisomerase II alpha status as predictive markers in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy.
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Comparison of DNA topoisomerase II alpha expression in small cell and nonsmall cell carcinoma of the lung. In search of a mechanism of chemotherapeutic response.
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Comparison of immunohistochemical and fluorescence in situ hybridization assessment for HER-2/neu status in Taiwanese breast cancer patients.
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Comparison of multidrug resistance gene expression levels with malignant potentials and influence of chemotherapy in urothelial cancers.
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Comparison of the mRNA expression of factors related to drug resistance in lung tumors and adjacent normal tissue.
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Comparison of topoisomerase-IIalpha gene status between primary breast cancer and corresponding distant metastatic sites.
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Complex alternative splicing of the smarca2 gene suggests the importance of smarca2-B variants.
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Components of intrinsic drug resistance in the rat hepatoma.
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Computational screening of chalcones acting against topoisomerase II? and their cytotoxicity towards cancer cell lines.
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Concentration-dependent variable effects of etoposide on the cell cycle of CML cells.
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Concentration-response studies of the chromosome-damaging effects of topoisomerase II inhibitors determined in vitro using human TK6 cells.
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Concurrent inhibition of enzymatic activity and NF-Y-mediated transcription of Topoisomerase-II? by bis-DemethoxyCurcumin in cancer cells.
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Conditional expression of wild-type topoisomerase II complements a mutant enzyme in mammalian cells.
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Contemporary Challenges in the Design of Topoisomerase II Inhibitors for Cancer Chemotherapy.
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Coordinate changes in drug resistance and drug-induced conformational transitions in altered-function mutants of the multidrug transporter P-glycoprotein.
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Copy number variation and high expression of DNA topoisomerase II alpha predict worse prognosis of cancer: a meta-analysis.
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Correlation between chromosome damage and apoptosis induced by fludarabine and idarubicin in normal human lymphocytes.
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Correlation between ER, PR, HER-2, Bcl-2, p53, proliferative and apoptotic indexes with HER-2 gene amplification and TOP2A gene amplification and deletion in four molecular subtypes of breast cancer.
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Correlation between p53, c-erbB-2, and topoisomerase II alpha expression, DNA ploidy, hormonal receptor status and proliferation in 356 node-negative breast carcinomas: prognostic implications.
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Correlation between Topo II alpha expression and chemosensitivity testing for Topo II-targeting drugs in gynaecological carcinomas.
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Correlation of tissue inhibitor of metalloproteinase-2 with proliferative activity and patients' survival in breast cancer.
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Correlations of ICAM-1 gene polymorphisms with susceptibility and multidrug resistance in colorectal cancer in a Chinese population.
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Correlations of TOP2A gene aberrations and expression of topoisomerase II? protein and TOP2A mRNA expression in primary breast cancer: a retrospective study of 86 cases using fluorescence in situ hybridization and immunohistochemistry.
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CORRELATIONSHIP OF CATHEPSIN D AND TOPOISOMERASE II ALPHA WITH NUCLEAR GRADING IN BREAST CANCERS.
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Correspondence re: M. Provencio, et al. the topoisomerase IIa expression correlates with survival in patients with advanced Hodgkin's lymphoma. Clin. Cancer Res., 9: 1406-1411, 2003.
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Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death.
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Cross-resistance to diverse drugs is associated with primary cisplatin resistance in ovarian cancer cell lines.
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Culprit and victim -- DNA topoisomerase II.
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Curcumin as a DNA topoisomerase II poison.
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Curcumin downregulates H19 gene transcription in tumor cells.
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Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells.
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Cyclins D1 and D3 and topoisomerase II alpha in inactive pituitary adenomas.
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Cysteine metabolic circuitries: druggable targets in cancer.
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Cytochemical markers of murine leukemias and lymphomas.
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Cytoplasmic localization of a mutant M(r) 160,000 topoisomerase II alpha is associated with the loss of putative bipartite nuclear localization signals in a drug-resistant human lung cancer cell line.
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Cytotoxic activity of topoisomerase II inhibitors in primary cultures of tumor cells from patients with human hematologic and solid tumors.
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Cytotoxicity and cell death mechanisms induced by the polyamine-vectorized anti-cancer drug F14512 targeting topoisomerase II.
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Cytotoxicity and cellular uptake of doxorubicin and its formamidine derivatives in HL60 sensitive and HL60/MX2 resistant cells.
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Cytotoxicity and inhibitory properties against topoisomerase II of doxorubicin and its formamidine derivatives.
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Cytotoxicity and preliminary mode of action studies of novel 2-aryl-4-thiopyrone-based organometallics.
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Cytotoxicity mediated by tumor necrosis factor in variant subclones of the ME-180 cervical carcinoma line: modulation by specific inhibitors of DNA topoisomerase II.
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Cytotoxicity of bioactive polymeric fractions from grape cell culture on human hepatocellular carcinoma, murine leukemia and non-cancerous PK15 kidney cells.
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Daunorubicin, a topoisomerase II poison, suppresses viral production of hepatitis B virus by inducing cGAS-dependent innate immune response.
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Decreased DNA topoisomerase II in daunorubicin-resistant Ehrlich ascites tumor cells.
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Decreased glycolytic metabolism accelerates apoptosis in response to 2-acetyl furanonaphthoquinone in K1735 melanoma irrespective of bcl-2 overexpression.
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Decreased levels of topoisomerase II alpha in human renal cell carcinoma lines resistant to etoposide.
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Defining functional drug-interaction domains on topoisomerase II by exploiting mechanistic differences between drug classes.
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Degron mediated BRM/SMARCA2 depletion uncovers novel combination partners for treatment of BRG1/SMARCA4-mutant cancers.
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Depletion of the ER chaperone ENPL-1 sensitizes C. elegans to the anticancer drug cisplatin.
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Deregulated levels of RUVBL1 induce transcription-dependent replication stress.
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Derivative of 5-cyano-6-phenylpyrimidin antagonizes ABCB1- and ABCG2-mediated multidrug resistance.
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Design and synthesis of 3,5-substituted 1,2,4-oxadiazoles as catalytic inhibitors of human DNA topoisomerase II?.
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Design and synthesis of conformationally constrained hydroxylated 4-phenyl-2-aryl chromenopyridines as novel and selective topoisomerase II-targeted antiproliferative agents.
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Design and synthesis of novel 2,4-diaryl-5H-indeno[1,2-b]pyridine derivatives, and their evaluation of topoisomerase inhibitory activity and cytotoxicity.
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Design, Synthesis and Anti-Tumor Activity of Novel Benzimidazole-Chalcone Hybrids as Non-Intercalative Topoisomerase II Catalytic Inhibitors.
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Design, synthesis and bioevaluation of inhibitors targeting HSP90-CDC37 protein-protein interaction based on a hydrophobic core.
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Design, synthesis and biological evaluation of novel perimidine o-quinone derivatives as non-intercalative topoisomerase II catalytic inhibitors.
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Design, Synthesis and Cancer Cell Growth Inhibition Evaluation of New Aminoquinone Hybrid Molecules.
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Design, synthesis and evaluation of new marine alkaloid-derived pentacyclic structures with anti-tumoral potency.
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Design, synthesis, and biological evaluation of ellipticine-estradiol conjugates.
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Design, synthesis, and evaluation of psorospermin/quinobenzoxazine hybrids as structurally novel antitumor agents.
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Design, synthesis, bioevaluation of LFC- and PA-tethered anthraquinone analogues of mitoxantrone.
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Design, synthesis, dynamic docking, biochemical characterization, and in vivo pharmacokinetics studies of novel topoisomerase II poisons with promising antiproliferative activity.
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Detection of gene amplification in archival breast cancer specimens by laser-assisted microdissection and quantitative real-time polymerase chain reaction.
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Detection of human topoisomerase II alpha in cell lines and tissues: characterization of five novel monoclonal antibodies.
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Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors.
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Detection of the ATPase activity of the molecular chaperones Hsp90 and Hsp72 using the TranscreenerTM ADP assay kit.
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Determinants of response to the DNA topoisomerase II inhibitors doxorubicin and etoposide in human lung cancer cell lines.
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Development and characterization of five cell models for chemoresistance studies of human ovarian carcinoma.
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Development and validation of a liquid chromatography-mass spectrometry (LC-MS) assay for the determination of the anti-cancer agent N-[2-(dimethylamino)ethyl]-2,6-dimethyl-1-oxo-1,2-dihydrobenzo[b]-1,6-naphthyridine-4-carboxamide (SN 28049).
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Development of Furo[2,3-b]quinoline Derivatives with Anti-Breast Cancer Property by Targeting Topoisomerase II.
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Development of novel alkylating drugs as anticancer agents.
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Dexrazoxane (ICRF-187).
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Dibutyltin(IV) complexes containing arylazobenzoate ligands: chemistry, in vitro cytotoxic effects on human tumor cell lines and mode of interaction with some enzymes.
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Dicentrine Analogue-Induced G2/M Arrest and Apoptosis through Inhibition of Topoisomerase II Activity in Human Cancer Cells.
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Dietary factors and the risk for acute infant leukemia: evaluating the effects of cocoa-derived flavanols on DNA topoisomerase activity.
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Differences between normal and ras-transformed NIH-3T3 cells in expression of the 170kD and 180kD forms of topoisomerase II.
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Differential cytotoxic effects of docetaxel in a range of mammalian tumor cell lines and certain drug resistant sublines in vitro.
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Differential effects of 2,4-dinitrophenol and valinomycin (+ K+) on uncoupler-stimulated ATPase of human tumor mitochondria.
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Differential effects of amsacrine and epipodophyllotoxins on topoisomerase II cleavage in the human c-myc protooncogene.
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Differential expression of DNA topoisomerase II alpha and II beta genes between small cell and non-small cell lung cancer.
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Differential expression of DNA topoisomerases in non-small cell lung cancer and normal lung.
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Differential expression of the drug resistance markers DNA topoisomerase II alpha and glutathione S-transferase-pi in the histological compartments of Wilms' tumors.
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Differential expression of the topoisomerase II alpha and beta genes in human breast cancers.
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Differential expression of topoisomerase IIalpha protein in salivary gland carcinomas: histogenetic and prognostic implications.
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Differential gene expression in colon carcinoma cells and tissues detected with a cDNA array.
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Differential immunohistochemical staining for DNA topoisomerase II alpha and beta in human tissues and for DNA topoisomerase II beta in non-Hodgkin's lymphomas.
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Differential increase in topoisomerase II in simian virus 40-infected cells.
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Differential induction of secondary DNA fragmentation by topoisomerase II inhibitors in human tumor cell lines with amplified c-myc expression.
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Differential protein expression using proteomics from a crustacean brine shrimp (Artemia sinica) under CO2-driven seawater acidification.
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Differential sensitivity of human gastric cancer ATPase and normal gastric mucosa ATPase to the synthetic mammalian lignan analogue 2,3-dibenzylbutane-1,4-diol (hattalin).
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Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients.
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Direct demonstration of high affinity interactions of immunosuppressant drugs with the drug binding site of the human P-glycoprotein.
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Direct Monitoring of the Strand Passage Reaction of DNA Topoisomerase II Triggers Checkpoint Activation.
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Discovery and development of pyrazole-scaffold Hsp90 inhibitors.
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Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification.
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Discovery of New Catalytic Topoisomerase II Inhibitors for Anticancer Therapeutics.
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Discovery of Novel Topoisomerase II Inhibitors by Medicinal Chemistry Approaches.
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Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers.
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Diverging effects of 5-HT3 receptor antagonists ondansetron and granisetron on estramustine-inhibited cellular potassium transport.
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DNA copy number changes in high-grade malignant peripheral nerve sheath tumors by array CGH.
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DNA damage and apoptosis induced by a potent orally podophyllotoxin derivative in breast cancer.
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DNA damage following combination of radiation with the bioreductive drug AQ4N: possible selective toxicity to oxic and hypoxic tumour cells.
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DNA damage signals induction of fas ligand in tumor cells.
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DNA intercalating anti-tumour agents.
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DNA Repair Gene Patterns as Prognostic and Predictive Factors in Molecular Breast Cancer Subtypes.
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DNA sequence selectivity of topoisomerases and topoisomerase poisons.
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DNA strand breaks induced by the anti-topoisomerase II bis-dioxopiperazine ICRF-193.
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DNA topoisomerase 1 and 2A function as oncogenes in liver cancer and may be direct targets of nitidine chloride.
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DNA topoisomerase I and II expression in drug resistant germ cell tumours.
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DNA topoisomerase I and IIalpha expression in penile carcinomas: assessing potential tumour chemosensitivity.
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DNA topoisomerase II alpha and Ki-67 in human adrenocortical neoplasms: a possible marker of differentiation between adenomas and carcinomas.
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DNA topoisomerase II alpha gene expression under transcriptional control in etoposide/teniposide-resistant human cancer cells.
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DNA topoisomerase II as a potential factor in drug resistance of human malignancies.
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DNA topoisomerase II as a target for cancer chemotherapy.
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DNA Topoisomerase II Enzymes as Molecular Targets for Cancer Chemotherapy.
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DNA topoisomerase II immunostaining in human leukemia and rhabdomyosarcoma cell lines and their responses to topoisomerase II inhibitors.
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DNA topoisomerase II inhibitors induce macrophage ABCA1 expression and cholesterol efflux-An LXR-dependent mechanism.
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DNA topoisomerase II mutations and resistance to anti-tumor drugs.
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DNA topoisomerase II, genotoxicity, and cancer.
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DNA topoisomerase II-alpha and cyclin A immunoexpression in meningiomas and its prognostic significance: an analysis of 263 cases.
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DNA Topoisomerase II-alpha as a marker of cell proliferation in endocrine and other neoplasms.
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DNA topoisomerase II-alpha as a proliferation marker in astrocytic neoplasms of the central nervous system: correlation with MIB1 expression and patient survival.
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DNA topoisomerase II-alpha as a proliferation marker in human gliomas: correlation with PCNA expression and patient survival.
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DNA topoisomerase II-alpha immunoreactivity as a marker of tumor aggressiveness in invasive breast cancer.
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DNA topoisomerase II-dependent cytotoxicity of alkylaminoanthraquinones and their N-oxides.
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DNA topoisomerase II: a primer on the enzyme and its unique role as a multidrug target in cancer chemotherapy.
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DNA Topoisomerase II? contributes to the early steps of adipogenesis in 3T3-L1 cells.
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DNA topoisomerase IIalpha (TOP2A) inhibitors up-regulate fatty acid synthase gene expression in SK-Br3 breast cancer cells: in vitro evidence for a 'functional amplicon' involving FAS, Her-2/neu and TOP2A genes.
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DNA topoisomerase IIalpha and -beta expression in human ovarian cancer.
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DNA topoisomerase IIalpha and Her-2/neu gene dosages in pediatric malignant gliomas.
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DNA topoisomerase IIalpha expression and the response toprimary chemotherapy in breast cancer.
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DNA topoisomerase IIalpha expression correlates with cell proliferation but not with recurrence in intracranial meningiomas.
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DNA topoisomerase IIalpha expression in optic pathway gliomas of childhood.
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DNA topoisomerase IIalpha in multiple myeloma: a marker of cell proliferation and not drug resistance.
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DNA topoisomerase IIalpha predicts progression-free and overall survival in pediatric malignant non-brainstem gliomas.
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DNA topoisomerase IIalpha protein and mRNA expression in intracranial meningiomas.
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DNA topoisomerase: the mechanism of resistance to DNA topoisomerase II inhibitor VP-16.
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DNA topoisomerases in cancer chemotherapy: using enzymes to generate selective DNA damage.
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DNA-dependent protein kinase in leukaemia cells and correlation with drug sensitivity.
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DNA-intercalating ligands as anti-cancer drugs: prospects for future design.
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DOC45, a novel DNA damage-regulated nucleocytoplasmic ATPase that is overexpressed in multiple human malignancies.
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Does the primary site really matter? Profiling mucinous ovarian cancers of uncertain primary origin (MO-CUP) to personalise treatment and inform the design of clinical trials.
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Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers.
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Dose escalation study to evaluate safety, tolerability and efficacy of intravenous etoposide phosphate administration in 27 dogs with multicentric lymphoma.
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Down-regulation of topoisomerase II alpha is caused by up-regulation of GRP78.
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Down-regulation of topoisomerase II by camptothecin does not prevent additive activity of the topoisomerase II inhibitor etoposide in vitro.
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Down-regulation of topoisomerase IIalpha in CEM cells selected for merbarone resistance is associated with reduced expression of Sp3.
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Doxorubicin induces an extensive transcriptional and metabolic rewiring in yeast cells.
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Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management.
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Drivers of topoisomerase II poisoning mimic and complement cytotoxicity in AML cells.
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Drug Design Targeting T-Cell Factor-Driven Epithelial-Mesenchymal Transition as a Therapeutic Strategy for Colorectal Cancer.
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Drug resistance gene expression and chemotherapy sensitivity detection in Chinese women with different molecular subtypes of breast cancer.
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Drug resistance to topoisomerase II inhibitors.
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Drug resistance-associated factors in primary and secondary glioblastomas and their precursor tumors.
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Drug-induced apoptosis is delayed and reduced in XPD lymphoblastoid cell lines: possible role of TFIIH in p53-mediated apoptotic cell death.
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Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin.
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Drug-resistance gene expression and progression of astrocytic tumors.
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Drug-stimulated ATPase activity of the human P-glycoprotein.
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Drugging the 'undruggable'. Therapeutic targeting of protein-DNA interactions with the use of computer-aided drug discovery methods.
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DTA0100, dual topoisomerase II and microtubule inhibitor, evades paclitaxel resistance in P-glycoprotein overexpressing cancer cells.
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Dual antibacterial and anticancer activity of 4-benzoyl-1-dichlorobenzoylthiosemicarbazide derivatives.
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Dual functions of a monoclonal antibody against cell surface F1F0 ATP synthase on both HUVEC and tumor cells.
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Dual functions of the homeoprotein DLX4 in modulating responsiveness of tumor cells to topoisomerase II-targeting drugs.
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Dual inhibition of topoisomerase II and tubulin polymerization by azatoxin, a novel cytotoxic agent.
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Dual Inhibition of Topoisomerase II and Tyrosine Kinases by the Novel Bis-Fluoroquinolone Chalcone-Like Derivative HMNE3 in Human Pancreatic Cancer Cells.
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Dual Inhibitors of Human DNA Topoisomerase II and Other Cancer-Related Targets.
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Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type.
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Dual mode of binding of anti cancer drug epirubicin to G-quadruplex [d-(TTAGGGT)]4 containing human telomeric DNA sequence induces thermal stabilization.
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Dual modes of death induced by etoposide in human epithelial tumor cells allow Bcl-2 to inhibit apoptosis without affecting clonogenic survival.
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Dual Targeting of Histone Deacetylase and Topoisomerase II with Novel Bifunctional Inhibitors.
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Dual targeting of microtubule and topoisomerase II by ?-carboline derivative YCH337 for tumor proliferation and growth inhibition.
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E1A specifically enhances sensitivity to topoisomerase IIalpha targeting anticancer drug by up-regulating the promoter activity.
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E2F-dependent repression of topoisomerase II regulates heterochromatin formation and apoptosis in cells with melanoma-prone mutation.
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EBNA1 may prolong G(2)/M phase and sensitize HER2/neu-overexpressing ovarian cancer cells to both topoisomerase II-targeting and paclitaxel drugs.
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Effect of a novel inhibitory mAb against beta-subunit of F1F0 ATPase on HCC.
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Effect of CD26/dipeptidyl peptidase IV on Jurkat sensitivity to G2/M arrest induced by topoisomerase II inhibitors.
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Effect of germinated soy protein on the growth of HeLa cervical cancer cells in female athymic mice.
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Effect of inhibitors of poly(ADP-ribose) polymerase on the induction of GRP78 and subsequent development of resistance to etoposide.
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Effect of Propionibacterium acnes or BCG on enzyme activities in spleen lymphocytes of Donryu strain rats.
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Effect of the different phosphorylated Smad2 protein localizations on the invasive breast carcinoma phenotype.
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Effect of yerba mate (Ilex paraguariensis) tea on topoisomerase inhibition and oral carcinoma cell proliferation.
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Effects of chronic growth hormone hypersecretion on intrinsic contractility, energetics, isomyosin pattern, and myosin adenosine triphosphatase activity of rat left ventricle.
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Effects of cinobufacini injection on cell proliferation and the expression of topoisomerases in human HepG-2 hepatocellular carcinoma cells.
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Effects of DNA topoisomerase II inhibitors on human bone marrow progenitor cells.
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Effects of ER-37328 on primary tumor, liver metastasis, and life span in a murine colon 38 orthotopic transplantation model.
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Effects of HER-2/neu on chemosensitivity of tumor cells.
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Effects of mutations within the SV40 large T antigen ATPase/p53 binding domain on viral replication and transformation.
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Effects of the DNA topoisomerase II inhibitor merbarone in male mouse meiotic divisions in vivo: cell cycle arrest and induction of aneuploidy.
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Effects of topoisomerases inhibitors protoberberine on Leishmania donovani growth, macrophage function, and infection.
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Effects of wild-type p53 expression on the quantity and activity of topoisomerase IIalpha and beta in various human cancer cell lines.
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Efficacy and Safety of CAP7.1 as Second-Line Treatment for Advanced Biliary Tract Cancers: Data from a Randomised Phase II Study.
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Efficacy of Acylfulvene Illudin analogues against a metastatic lung carcinoma MV522 xenograft nonresponsive to traditional anticancer agents: retention of activity against various mdr phenotypes and unusual cytotoxicity against ERCC2 and ERCC3 DNA helicase-deficient cells.
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Efficacy of substituted 9-aminoacridine derivatives in small cell lung cancer.
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Eg5 inhibitor YL001 induces mitotic arrest and inhibits tumor proliferation.
Neoplasms
Eg5 targeting agents: From new anti-mitotic based inhibitor discovery to cancer therapy and resistance.
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Electromagnetic modulation of biological processes: ATPase function and DNA production by Raji cancer cells in vitro.
Neoplasms
Electron microscopic study of the ATPase activity of the BAI strain A (myeloblastosis) avian tumor virus.
Neoplasms
Elevated cyclooxygenase-2 expression correlates with diminished survival in carcinoma of the cervix treated with radiotherapy.
Neoplasms
Elevated expression of DNA topoisomerase II in camptothecin-resistant human tumor cell lines.
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Elevated TOP2A and UBE2C expressions correlate with poor prognosis in patients with surgically resected lung adenocarcinoma: a study based on immunohistochemical analysis and bioinformatics.
Neoplasms
Elevated TRIP13 drives the AKT/mTOR pathway to induce the progression of hepatocellular carcinoma via interacting with ACTN4.
Neoplasms
Elevations of DNA topoisomerase I in transitional cell carcinoma of the urinary bladder: correlation with DNA topoisomerase II-alpha and p53 expression.
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Endogenous tumor necrosis factor enhances topoisomerase II inhibitors activity in human ovarian cancer cell lines.
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Endostatin has ATPase activity, which mediates its antiangiogenic and antitumor activities.
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Enhanced B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II poison-resistant cancer cells.
Neoplasms
Enhanced drug internalization and therapeutic efficacy of PEGylated nanoparticles by one-step formulation with anti-mPEG bispecific antibody in intrinsic drug-resistant breast cancer.
Neoplasms
Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity.
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Enhanced expression of the DNA topoisomerase II gene in response to heat shock stress in human epidermoid cancer KB cells.
Neoplasms
Enhanced sensitivity to 1-beta-D-arabinofuranosylcytosine and topoisomerase II inhibitors in tumor cell lines harboring activated ras oncogenes.
Neoplasms
Enhanced sensitivity to tumor necrosis factor-alpha in doxorubicin-resistant tumor cell lines due to down-regulated c-erbB2.
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Enhanced topoisomerase I activity and increased topoisomerase II alpha content in cisplatin-resistant cancer cell lines.
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Enhancing the antiproliferative effect of topoisomerase II inhibitors using a polypeptide inhibitor of c-Myc.
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Enzyme histochemical study on bone tumors.
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Epigenetic Combination Therapy for Children With Secondary Myelodysplastic Syndrome (MDS)/Acute Myeloid Leukemia (AML) and Concurrent Solid Tumor Relapse.
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Epigenetically maintained SW13+ and SW13- subtypes have different oncogenic potential and convert with HDAC1 inhibition.
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Epigenetics and cancer: altered chromatin remodeling via Snf5 loss leads to aberrant cell cycle regulation.
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ER, HER2, and TOP2A expression in primary tumor, synchronous axillary nodes, and asynchronous metastases in breast cancer.
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ERK1/2 signaling plays an important role in topoisomerase II poison-induced G2/M checkpoint activation.
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Establishment and Characterisation by Expression Microarray of Patient-Derived Xenograft Panel of Human Pancreatic Adenocarcinoma Patients.
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Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer.
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Etoposide induces heritable chromosomal aberrations and aneuploidy during male meiosis in the mouse.
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Etoposide quinone is a covalent poison of human topoisomerase II?.
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Etoposide quinone is a redox-dependent topoisomerase II poison.
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Etoposide, topoisomerase II and cancer.
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Etoposide-induced cytogenotoxicity in mouse spermatogonia and its potential transmission.
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Etoposide-induced DNA cleavage in human leukemia cells.
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Etoposide-induced PC12 cell death: apoptotic morphology without oligonucleosomal DNA fragmentation or dependency upon de novo protein synthesis.
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Etoposide-mediated glioblastoma cell death: dependent or independent on the expression of its target, topoisomerase II alpha?
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Evaluating the specificity of antisense oligonucleotide conjugates. A DNA array analysis.
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Evaluation of GL331 in combination with paclitaxel: GL331's interference with paclitaxel-induced cell cycle perturbation and apoptosis.
Neoplasms
Evaluation of pemetrexed and etoposide as therapeutic regimens for human papillomavirus-positive oral and oropharyngeal cancer.
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Evaluation of S9788 as a potential modulator of drug resistance against human tumour sublines expressing differing resistance mechanisms in vitro.
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Evaluation of the predictive value of topoisomerase II alpha in patients with breast carcinoma.
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Evaluation of the prognostic role of centromere 17 gain and HER2/topoisomerase II alpha gene status and protein expression in patients with breast cancer treated with anthracycline-containing adjuvant chemotherapy: pooled analysis of two Hellenic Cooperative Oncology Group (HeCOG) phase III trials.
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Evaluation of topoisomerase II, ki-67, and P53 expression in non-muscle-invasive urothelial carcinoma and their clinical significance.
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Evaluation of topoisomerase IIa expression in pancreatic ductal adenocarcinoma: a pilot study using chromogenic in situ hybridization and immunohistochemistry on tissue microarrays.
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Evidence for a mutant allele of the gene for DNA topoisomerase II in adriamycin-resistant P388 murine leukemia cells.
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Evidence for predictive role of BRCA1 and bTUBIII in gastric cancer.
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Evidence of a reduced DNA topoisomerase II mRNA expression after ionizing radiation.
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Evoked effects of PGE2 and PGA2 on lipid fluidity and Ca2+-stimulated ATPase of Walker-256 tumor microsomal membranes.
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Evolution from heterozygous to homozygous KIT mutation in gastrointestinal stromal tumor correlates with the mechanism of mitotic nondisjunction and significant tumor progression.
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Ex vivo characterization of XR11576 (MLN576) against ovarian cancer and other solid tumors.
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Ex vivo effects of the dual topoisomerase inhibitor tafluposide (F 11782) on cells isolated from fresh tumor samples taken from patients with cancer.
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Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix-assisted laser desorption/ionisation mass spectrometry.
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Experimental antitumour activity of S 16020-2 in a panel of human tumours.
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Experimental evaluation of the usefulness of 201Tl-chloride scintigraphy for monitoring radiotherapeutic effects.
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Experimental solid tumour activity of N-[2-(dimethylamino)ethyl]-acridine-4-carboxamide.
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Exploring weak ligand-protein interactions by long-lived NMR states: improved contrast in fragment-based drug screening.
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Expression and clinical significance of multidrug resistance proteins in brain tumors.
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Expression and inhibition of BRD4, EZH2 and TOP2A in neurofibromas and malignant peripheral nerve sheath tumors.
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Expression and integrity of DNA topoisomerase II isoforms does not explain generic drug resistance in malignant mesothelioma.
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Expression and relationship between topoisomerase I and II alpha genes in tumor and normal tissues in esophageal, gastric and colon cancers.
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Expression of a molecular marker panel as a prognostic tool in gastric cancer patients treated postoperatively with docetaxel and irinotecan. A study of the Hellenic Cooperative Oncology Group.
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Expression of acidosis-dependent genes in human cancer nests.
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Expression of Bcl-2 in human epithelial tumor (HeLa) cells enhances clonogenic survival following exposure to 5-fluoro-2'-deoxyuridine or staurosporine, but not following exposure to etoposide or doxorubicin.
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Expression of cell proliferation markers in pituitary adenomas--correlation and clinical relevance of MIB-1 and anti-topoisomerase-IIalpha.
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Expression of cellular apoptosis susceptibility protein in serous ovarian carcinoma: a clinicopathologic and immunohistochemical study.
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Expression of cyclin A and topoisomerase IIalpha of oligodendrogliomas is correlated with tumour grade, MIB-1 labelling index and survival.
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Expression of DNA topoisomerase I and DNA topoisomerase II-alpha in carcinoma of the colon.
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Expression of DNA topoisomerase I in neoplasms of the kidney: correlation with histological grade, proliferation, and patient survival.
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Expression of DNA topoisomerase I, DNA topoisomerase II-alpha, and p53 in metastatic malignant melanoma.
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Expression of DNA topoisomerase IIalpha and topoisomerase IIbeta genes predicts survival and response to chemotherapy in patients with small cell lung cancer.
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Expression of DNA topoisomerase IIalpha in thyroid neoplasia.
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Expression of drug resistance related proteins in sarcomas of the pulmonary artery and poorly differentiated leiomyosarcomas of other origin.
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Expression of E-cadherin, beta-catenin and topoisomerase IIalpha in leiomyosarcomas.
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Expression of human DNA Topoisomerase II-alpha in squamous cell carcinoma of the larynx and its correlation with clinicopathologic variables.
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Expression of human MCM6 and DNA Topo II alpha in craniopharyngiomas and its correlation with recurrence of the tumor.
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Expression of Ki-67, topoisomerase IIalpha and c-MYC in astrocytic tumors: correlation with the histopathological grade and proliferative status.
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Expression of M2 macrophage markers YKL-39 and CCL18 in breast cancer is associated with the effect of neoadjuvant chemotherapy.
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Expression of MDR1, GST-pi and topoisomerase II as an indicator of clinical response to adriamycin.
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Expression of multidrug resistance-related genes (mdrl, MRP, GST-pi and DNA topoisomerase II) in urothelial cancers.
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Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways.
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Expression of P-glycoprotein and multidrug resistance associated protein in Ehrlich ascites tumor cells after fractionated irradiation.
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Expression of p270 (ARID1A), a component of human SWI/SNF complexes, in human tumors.
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Expression of the Na(+)/K(+)-transporting ATPase gamma subunit FXYD2 in renal tumors.
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Expression of the Topoisomerase II Alpha (TOP2A) Gene in Lung Adenocarcinoma Cells and the Association with Patient Outcomes.
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Expression of topoisomerase II alpha and beta in an adenocarcinoma cell line carrying amplified topoisomerase II alpha and retinoic acid receptor alpha genes.
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EXPRESSION OF TOPOISOMERASE II ALPHA, KI67 AND P53 IN PRIMARY NON-MUSCLE-INVASIVE UROTHELIAL BLADDER CARCINOMA.
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Expression of topoisomerase II and Ki-67 in cervical carcinoma--clinicopathological study using immunohistochemistry.
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Expression of topoisomerase IIalpha is associated with rapid cell proliferation, aneuploidy, and c-erbB2 overexpression in breast cancer.
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Expression of topoisomerase IIalpha, Ki-67, proliferating cell nuclear antigen, p53, and argyrophilic nucleolar organizer regions in vulvar squamous lesions.
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Expression, domain structure, and enzymatic properties of an active recombinant human DNA topoisomerase II beta.
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Expression, regulation and clinical relevance of the ATPase inhibitory factor 1 in human cancers.
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Extensive analysis of the molecular biomarkers excision repair cross complementing 1, ribonucleotide reductase M1, ?-tubulin III, thymidylate synthetase, and topoisomerase II? in breast cancer: Association with clinicopathological characteristics.
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Extra copies of chromosomes 16 and X in invasive breast carcinomas are related to aggressive phenotype and poor prognosis.
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EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors.
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F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system.
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Facilitating Akt clearance via manipulation of Hsp70 activity and levels.
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Factors contributing to adriamycin sensitivity in human xenograft tumors: the relationship between expression of the MDR1, GST-pi and topoisomerase II genes and tumor sensitivity to adriamycin.
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FANCM regulates repair pathway choice at stalled replication forks.
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FBXW7 mediates chemotherapeutic sensitivity and prognosis in NSCLCs.
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Features of potentially predictive biomarkers of chemotherapeutic efficacy in small cell lung cancer.
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Flurazepam inhibits the P-glycoprotein transport function: an insight to revert multidrug-resistance phenotype.
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Formaldehyde-activated Pixantrone is a monofunctional DNA alkylator that binds selectively to CpG and CpA doublets.
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Formaldehyde-releasing prodrugs in combination with adriamycin can overcome cellular drug resistance.
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Fostriecin: a review of the preclinical data.
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Free radical scavengers can differentially modulate the genotoxicity of amsacrine in normal and cancer cells.
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From Bacteria to Cancer: A Benzothiazole-Based DNA Gyrase B Inhibitor Redesigned for Hsp90 C-Terminal Inhibition.
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From the Cover: Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.
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Fully human anti-CD39 antibody potently inhibits ATPase activity in cancer cells via uncompetitive allosteric mechanism.
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Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells.
Neoplasms
Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers.
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Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complex.
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Further SAR studies on bicyclic basic merbarone analogues as potent antiproliferative agents.
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Fusion protein of ATPase domain of Hsc70 with TRP2 acting as a tumor vaccine against B16 melanoma.
Neoplasms
Gastrointestinal stromal tumors - quantitative detection of the Ki-67, TPX2, TOP2A, and hTERT telomerase subunit mRNA levels to determine a proliferation activity and a potential for aggressive biological behavior.
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Gemcitabine plus conventional-dose epirubicin versus gemcitabine plus cisplatin as first-line chemotherapy for stage IIIB/IV non-small cell lung carcinoma--a randomized phase II trial.
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Gene copy mapping of the ERBB2/TOP2A region in breast cancer.
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Gene expression analysis for predicting gemcitabine sensitivity in pancreatic cancer patients.
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Gene expression of DNA topoisomerases I, II alpha and II beta and response to cisplatin-based chemotherapy in advanced ovarian carcinoma.
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Gene expression of topoisomerase II alpha (TOP2A) by microarray analysis is highly prognostic in estrogen receptor (ER) positive breast cancer.
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Gene expression profiles in cells transformed by overexpression of the IGF-I receptor.
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Gene expression profiling of breast cancer patients treated with docetaxel, doxorubicin, and cyclophosphamide within the GEPARTRIO trial: HER-2, but not topoisomerase II alpha and microtubule-associated protein tau, is highly predictive of tumor response.
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Gene Silencing Associated with SWI/SNF Complex Loss during NSCLC Development.
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Genetic and epigenetic screening for gene alterations of the chromatin-remodeling factor, SMARCA4/BRG1, in lung tumors.
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Genome-Wide Identification and Characterization of Novel Factors Conferring Resistance to Topoisomerase II Poisons in Cancer.
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Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines.
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Genomic landscape of small cell carcinoma of the breast contrasted to small cell carcinoma of the lung.
Neoplasms
Global analysis of gene expression signature and diagnostic/prognostic biomarker identification of hepatocellular carcinoma.
Neoplasms
Glucose-regulated stresses cause degradation of DNA topoisomerase IIalpha by inducing nuclear proteasome during G1 cell cycle arrest in cancer cells.
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Glucose-regulated stresses confer resistance to VP-16 in human cancer cells through a decreased expression of DNA topoisomerase II.
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Glutathione metabolism and glutathione S-conjugate export ATPase (MRP1/GS-X pump) activity in cancer. I. Differential expression in human cancer cell lines.
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Glutathione metabolism and glutathione S-conjugate export ATPase (MRP1/GS-X pump) activity in cancer. II. Cell-to-cell variability, relation with cellular activation state and functional absence of GS-X pump in lymphocytes.
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Going through the motions: the ATPase cycle of p97.
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Gossypol Interferes with Both Type I and Type II Topoisomerase Activities Without Generating Strand Breaks.
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Grade-dependent effects on cell cycle progression and apoptosis in response to doxorubicin in human bladder cancer cell lines.
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Granzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis.
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Green tea catechins augment the antitumor activity of doxorubicin in an in vivo mouse model for chemoresistant liver cancer.
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Growth-related elevations of DNA topoisomerase II levels found in Dunning R3327 rat prostatic adenocarcinomas.
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GSH-targeted nanosponges increase doxorubicin-induced toxicity "in vitro" and "in vivo" in cancer cells with high antioxidant defenses.
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HBXIP regulates etoposide-induced cell cycle checkpoints and apoptosis in MCF-7 human breast carcinoma cells.
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Hematologic abnormalities and acute myeloid leukemia in children and adolescents administered intensified chemotherapy for the Ewing sarcoma family of tumors.
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Hepatic dearterialization in 3'-methyl-4-dimethylaminoazo-benzene-induced hepatocellular carcinoma with special reference to circulatory dynamics and mitochondrial functions.
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HER-2 amplification and topoisomerase IIalpha gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil.
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HER-2 and TOP2A coamplification in urinary bladder cancer.
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HER-2 and topo-isomerase IIalpha as predictive markers in a population of node-positive breast cancer patients randomly treated with adjuvant CMF or epirubicin plus cyclophosphamide.
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HER-2/neu and topoisomerase IIalpha in breast cancer.
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HER2 and TOP2A amplification in a hospital-based cohort of breast cancer patients: associations with patient and tumor characteristics.
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HER2 and TOP2A Gene Amplification and Protein Expression in Upper Tract Urothelial Carcinomas.
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HER2 and topoisomerase IIalpha: possible predictors of response to neoadjuvant chemotherapy for breast cancer patients.
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HER2 expression and efficacy of preoperative paclitaxel/FAC chemotherapy in breast cancer.
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HER2, TOP2A, and TIMP-1 and responsiveness to adjuvant anthracycline-containing chemotherapy in high-risk breast cancer patients.
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Herpesviral G protein-coupled receptors activate NFAT to induce tumor formation via inhibiting the SERCA calcium ATPase.
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Heterogeneous expression of DNA topoisomerase II alpha isoforms in tumor cell lines.
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HIF1?-dependent upregulation of ATAD2 promotes proliferation and migration of stomach cancer cells in response to hypoxia.
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High antineoplastic activity of new heterocyclic compounds in cancer cells with resistance against classical DNA topoisomerase II-targeting drugs.
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High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer.
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High expression of TOP2A in hepatocellular carcinoma is associated with disease progression and poor prognosis.
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High expression of topoisomerase-II predicts favorable clinical outcomes in patients with relapsed small cell lung cancers receiving amrubicin.
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High levels of topoisomerase IIalpha protein expression in diffuse large B-cell lymphoma are associated with high proliferation, germinal center immunophenotype, and response to treatment.
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High risk of leukemia after short-term dose-intensive chemotherapy in young patients with solid tumors.
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High topoisomerase IIalpha expression associates with high proliferation rate and and poor prognosis in oligodendrogliomas.
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High-resolution genomic and expression analyses of copy number alterations in HER2-amplified breast cancer.
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Histochemical characteristics of spontaneous and chemically induced hepatocellular neoplasms in mice and the development of neoplasms with gamma-glutamyl transpeptidase activity during phenobarbital exposure.
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Histochemical evidence of adenosine triphosphatase activity in glomus tumor--report of a case.
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Histochemistry of liver tumors induced by diethylnitrosamine and differential sex susceptibility to carcinogenesis in Oryzias latipes.
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Histologic and genomic features of breast cancers with alterations affecting the SWI/SNF (SMARC) genes.
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HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha.
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Honokiol Bis-Dichloroacetate Is a Selective Allosteric Inhibitor of the Mitochondrial Chaperone TRAP1.
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HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H(+) ATPase.
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Hsp70 and the Unfolded Protein Response as a Challenging Drug Target and an Inspiration for Probe Molecule Development.
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Human cortical distal nephron: distribution of electrolyte and water transport pathways.
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Human cytomegalovirus (HCMV) IE1 plays role in resistance to apoptosis with etoposide in cancer cell line by Cdk2 accumulation.
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Human DNA topoisomerase I: An anticancer drug target present in human sarcomas.
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Human DNA topoisomerase II-alpha.
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Human DNA topoisomerase II-alpha: a new marker of cell proliferation in invasive breast cancer.
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Human homologue of the Drosophila discs large tumor suppressor protein forms an oligomer in solution. Identification of the self-association site.
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Human topoisomerase II alpha as a prognostic biomarker in cancer chemotherapy.
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Hybrid Graphene-Gold Nanoparticle-based Nucleic Acid Conjugates for Cancer-Specific Multimodal Imaging and Combined Therapeutics.
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Hypersensitivity of nonhomologous DNA end-joining mutants to VP-16 and ICRF-193: implications for the repair of topoisomerase II-mediated DNA damage.
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Hypoxia-selective targeting by the bioreductive prodrug AQ4N in patients with solid tumors: results of a phase I study.
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ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells.
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ICRF-187 rescue in etoposide treatment in vivo. A model targeting high-dose topoisomerase II poisons to CNS tumors.
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Idarubicin Stimulates Cell Cycle- and TET2-Dependent Oxidation of DNA 5-Methylcytosine in Cancer Cells.
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Identification and validation of prognostic markers in breast cancer with the complementary use of array-CGH and tissue microarrays.
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Identification of a novel amplicon at distal 17q containing the BIRC5/SURVIVIN gene in malignant peripheral nerve sheath tumours.
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Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach.
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Identification of a potential topoisomerase II "hotspot" DNA region in the DEK gene in two t(6;9)-positive therapy-related myeloid neoplasms.
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Identification of collaborative activities with oxidative phosphorylation in bipolar disorder.
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Identification of decatenation G2 checkpoint impairment independently of DNA damage G2 checkpoint in human lung cancer cell lines.
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Identification of differentially expressed genes in normal and tumor human gastric tissue.
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Identification of differentially expressed genes in pulmonary adenocarcinoma by using cDNA array.
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Identification of Five Genes as a Potential Biomarker for Predicting Progress and Prognosis in Adrenocortical Carcinoma.
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Identification of functional nuclear export sequences in human topoisomerase IIalpha and beta.
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Identification of key biomarkers associated with development and prognosis in patients with ovarian carcinoma: evidence from bioinformatic analysis.
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Identification of key candidate genes for colorectal cancer by bioinformatics analysis.
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Identification of molecular target genes and key pathways in hepatocellular carcinoma by bioinformatics analysis.
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Identification of New Hsp90 Inhibitors: Structure Based Virtual Screening, Molecular Dynamic Simulation, Synthesis and Biological Evaluation.
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Identification of potent catalytic inhibitors of human DNA topoisomerase II by structure-based virtual screening.
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Identification of potent virtual leads and ADME prediction of isoxazolidine podophyllotoxin derivatives as topoisomerase II and tubulin inhibitors.
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Identification of R2TP complex of Leishmania donovani and Plasmodium falciparum using genome wide in-silico analysis.
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Identification of Tumor Antigen AF20 as Glycosylated Transferrin Receptor 1 in Complex with Heat Shock Protein 90 and/or Transporting ATPase.
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Identification of two different states of P-glycoprotein in its catalytic cycle: role of the linker region in the transition between these two states.
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Image analysis using the fluorochromasia assay to quantify tumor drug sensitivity.
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Immunohistochemical analysis of p16INK4a, p14ARF, p18INK4c, p21CIP1, p27KIP1 and p73 expression in 271 meningiomas correlation with tumor grade and clinical outcome.
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Immunohistochemical and two-parameter flow cytometric studies of DNA topoisomerase II alpha in human epithelial ovarian carcinoma and germ cell tumor.
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Immunohistochemical detection of DNA topoisomerase IIalpha, P-glycoprotein and multidrug resistance protein (MRP) in small-cell and non-small-cell lung cancer.
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Immunohistochemical detection of P glycoprotein, glutathione S transferase and DNA topoisomerase II in human tumors.
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Immunohistochemical expression of topoisomerase IIalpha (Topo IIalpha) and multidrug resistance-associated protein (MRP), plus chemosensitivity testing, as chemotherapeutic indices of ovarian and endometrial carcinomas.
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Immunohistochemical localization of transport mediators in Wilms' tumor: comparison with fetal and mature human kidney.
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Immunohistochemical staining for DNA topoisomerase I, DNA topoisomerase II-alpha and p53 in gastric carcinomas.
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Immunohistochemical staining for DNA topoisomerase II in frozen and formalin-fixed paraffin-embedded human tissues.
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Immunohistochemical staining for DNA topoisomerase II in non-Hodgkin's lymphomas.
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Immunohistochemical staining for DNA topoisomerase II-alpha in benign, premalignant, and malignant lesions of the prostate.
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Immunohistochemical staining for DNA topoisomerase IIa in Hodgkin's disease.
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Immunohistochemical study of DNA topoisomerase II in human gastric disorders.
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Immunohistochemical study of Ki-67 and DNA topoisomerase II in human endometrium.
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Immunohistochemical study on topoisomerase IIalpha, Ki-67 and cytokeratin-19 in oral lichen planus lesions.
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Impact of histone deacetylase inhibitor valproic acid on the anticancer effect of etoposide on neuroblastoma cells.
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Improved anti-tumor reactivity with monoclonal anti-idiotypic antibody conjugated to syngeneic mouse red blood cells.
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Improved targeting of brain tumors using dexrazoxane rescue of topoisomerase II combined with supralethal doses of etoposide and teniposide.
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In Search of a Cure for Proteostasis-Addicted Cancer: A AAA Target Revealed.
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In situ generation of biocompatible amorphous calcium carbonate onto cell membrane to block membrane transport protein - A new strategy for cancer therapy via mimicking abnormal mineralization.
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In vitro and in vivo analysis of B-Myb in basal-like breast cancer.
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In vitro and in vivo reversal of cancer cell multidrug resistance by the semi-synthetic antibiotic tiamulin.
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In vitro anti-cancer activity of doxorubicin against human RNA helicase, DDX3.
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In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities.
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In vivo exposure to four ellipticine derivatives with topoisomerase inhibitory activity results in chromosome clumping and sister chromatid exchange in murine bone marrow cells.
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In vivo inhibition of the mitochondrial H+-ATP synthase in neurons promotes metabolic preconditioning.
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In vivo synergy between topoisomerase II and histone deacetylase inhibitors: predictive correlates.
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Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97.
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Incorporating cell proliferation kinetics into models for cancer risk assessment.
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Increased content of natural ATPase inhibitor in tumor mitochondria.
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Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints.
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Increased Expression of c-Met is Associated with Chemotherapy-Resistant Breast Cancer and Poor Clinical Outcome.
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Increased phosphorylation of DNA topoisomerase II in etoposide-resistant mutants of human cancer KB cells.
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Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout cells to antitumor triazoloacridone C-1305 is associated with permanent G2 cell cycle arrest.
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Increased topoisomerase IIalpha expression in colorectal cancer is associated with advanced disease and chemotherapeutic resistance via inhibition of apoptosis.
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Increased uptake of antisense oligonucleotides by delivery as double stranded complexes.
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Individualized chemotherapy guided by the expression of ERCC1, RRM1, TUBB3, TYMS and TOP2A genes versus classic chemotherapy in the treatment of breast cancer: A comparative effectiveness study.
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Induction of apoptosis in cholangiocarcinoma by an andrographolide analogue is mediated through topoisomerase II alpha inhibition.
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Induction of apoptosis of human tumor cells by a 4,9-diazapyrenium derivative and its affects on topoisomerase-II action.
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Induction of ATM activation, histone H2AX phosphorylation and apoptosis by etoposide: relation to cell cycle phase.
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Induction of topoisomerase II-mediated DNA cleavage by a protoberberine alkaloid, berberrubine.
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Infant acute lymphoblastic leukemia with t(11;16)(q23;p13.3) and lineage switch into acute monoblastic leukemia.
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Inhibition of AKT-Signaling Sensitizes Soft Tissue Sarcomas (STS) and Gastrointestinal Stromal Tumors (GIST) to Doxorubicin via Targeting of Homology-Mediated DNA Repair.
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Inhibition of angiogenesis involves in anticancer activity of riccardin D, a macrocyclic bisbibenzyl, in human lung carcinoma.
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Inhibition of CD39 Enzymatic Function at the Surface of Tumor Cells Alleviates Their Immunosuppressive Activity.
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Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor.
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Inhibition of DNA topoisomerase II by imidazoacridinones, new antineoplastic agents with strong activity against solid tumors.
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Inhibition of FGFR2-Signaling Attenuates a Homology-Mediated DNA Repair in GIST and Sensitizes Them to DNA-Topoisomerase II Inhibitors.
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Inhibition of fibroblast growth factor receptor-signaling sensitizes imatinib-resistant gastrointestinal stromal tumors to low doses of topoisomerase II inhibitors.
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Inhibition of Human Topoisomerases I and II by Simocyclinone D8.
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Inhibition of intracellular topoisomerase II by antitumor bis(2,6-dioxopiperazine) derivatives: mode of cell growth inhibition distinct from that of cleavable complex-forming type inhibitors.
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Inhibition of membrane Na(+)-K+ Atpase of the brain, liver and RBC in rats administered di(2-ethyl hexyl) phthalate (DEHP) a plasticizer used in polyvinyl chloride (PVC) blood storage bags.
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Inhibition of N-methyl-N-nitrosourea-induced mammary tumors in rats by the soybean isoflavones.
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Inhibition of NF-kappaB and proteasome activity in tumors: can we improve the therapeutic potential of topoisomerase I and topoisomerase II poisons.
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Inhibition of p38 MAPK-Dependent Excision Repair Cross-Complementing 1 Expression Decreases the DNA Repair Capacity to Sensitize Lung Cancer Cells to Etoposide.
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Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen.
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Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation.
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Inhibition of topoisomerase II ? activity and induction of apoptosis in mammalian cells by semi-synthetic andrographolide analogues.
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Inhibition of topoisomerase II activity and its effect on nucleolar structure and function.
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Inhibition of topoisomerase II by 8-chloro-adenosine triphosphate induces DNA double-stranded breaks in 8-chloro-adenosine-exposed human myelocytic leukemia K562 cells.
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Inhibition of topoisomerase II? sensitizes FaDu cells to ionizing radiation by diminishing DNA repair.
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Inhibition of topoisomerase IIalpha expression by transforming growth factor-beta1 is abrogated by the papillomavirus E7 protein.
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Inhibition of topoisomerases by antitumor prostaglandins.
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Inhibition of tumor angiogenesis by oral etoposide.
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Inhibition of V-ATPases and Carbonic Anhydrases as Interference Strategy with Tumor Acidification Processes.
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Inhibition of Vascular Calcification.
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Inhibitors of mTOR overcome drug resistance from topoisomerase II inhibitors in solid tumors.
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Inhibitors of topoisomerase II as pH-dependent modulators of etoposide-mediated cytotoxicity.
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Inhibitors of topoisomerase II prevent cytokine-induced expression of vascular cell adhesion molecule-1, while augmenting the expression of endothelial leukocyte adhesion molecule-1 on human umbilical vein endothelial cells.
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Inhibitors of topoisomerase II: structure-activity relationships and mechanism of action of podophyllin congeners.
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Inhibitory effect of coenzyme Q on eukaryotic DNA polymerase gamma and DNA topoisomerase II activities on the growth of a human cancer cell line.
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Inhibitory effect of riccardin D on growth of human non-small cell lung cancer: In vitro and in vivo studies.
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Inhibitory effects of a major soy isoflavone, genistein, on human DNA topoisomerase II activity and cancer cell proliferation.
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Inhibitory effects of docosyl p-coumarate on DNA topoisomerase activity and human cancer cell growth.
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Inhibitory effects of low molecular weight polyphenolics from Inonotus obliquus on human DNA topoisomerase activity and cancer cell proliferation.
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Integrated Bioinformatics Analysis of the Clinical Value and Biological Function of ATAD2 in Hepatocellular Carcinoma.
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Integrated clinicopathological features and gene microarray analysis of pancreatic neuroendocrine tumors.
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Interaction between tumor suppressor adenomatous polyposis coli and topoisomerase IIalpha: implication for the G2/M transition.
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Interaction of recombinant human tumor necrosis factor and etoposide in human lung cancer cell lines.
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Interactions between the Etoposide Derivative F14512 and Human Type II Topoisomerases: Implications for the C4 Spermine Moiety in Promoting Enzyme-Mediated DNA Cleavage.
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Interference with topoisomerase IIalpha potentiates melphalan cytotoxicity.
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Interlinked DNA nano-circles for measuring topoisomerase II activity at the level of single decatenation events.
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Intracellular accumulation of thallium as a marker of cisplatin cytotoxicity in nonsmall cell lung carcinoma: an application of inductively coupled plasma mass spectrometry.
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Intracellular ionic changes during hyperthermia of tumor cells in the presence of lanthanum.
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Intracellular molecular interactions of antitumor drug amsacrine (m-AMSA) as revealed by surface-enhanced Raman spectroscopy.
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Intracellular pH regulation in oral squamous cell carcinoma is mediated by increased V-ATPase activity via over-expression of the ATP6V1C1 gene.
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Intracranial hemangiopericytomas: correlation of topoisomerase IIalpha expression with biologic behavior.
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Intrinsic expression of drug resistance-associated factors in meningiomas.
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Inversion of chromosome 11 inv(11)(p15q22), as a recurring chromosomal aberration associated with de novo and secondary myeloid malignancies: identification of a P1 clone spanning the 11q22 breakpoint.
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Ionizing radiation and teniposide increase p21(waf1/cip1) and promote Rb dephosphorylation but fail to suppress E2F activity in MCF-7 breast tumor cells.
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Irinotecan and radiation in vitro and in vivo.
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Irradiation of rainbow trout at early life stages results in a proteomic legacy in adult gills. Part B; the effect of a second radiation dose, after one year, on the proteomic responses in the irradiated and non-irradiated bystander fish.
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Is age an independent risk factor for chemically induced acute myelogenous leukemia in children?
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IS METABOLIC ACTIVATION OF TOPOISOMERASE II POISONS IMPORTANT IN THE MECHANISM OF CYTOTOXICITY?
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Isolation and characterization of plasma membranes from transplantable human astrocytoma, oat cell carcinoma, and melanomas.
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Isolation and purification of normal and malignant colonic plasma membranes.
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Isolation of cDNA clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24.
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Isolation of cDNAs encoding chicken homologues of the yeast SNF2 and Drosophila Brahma proteins.
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Joint detection of multiple immunohistochemical indices and clinical significance in breast cancer.
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Ki-67 immunolabeling index is an accurate predictor of outcome in patients with intracranial ependymoma.
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Ki-S1--a prognostic marker for hypopharyngeal carcinoma with potential predictive value for response to chemotherapy.
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Kinesin family member 18B regulates the proliferation and invasion of human prostate cancer cells.
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Kinetics and regulation of cytochrome P450-mediated etoposide metabolism.
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Knockdown of OLA1, a regulator of oxidative stress response, inhibits motility and invasion of breast cancer cells.
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Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and gamma radiation.
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KW-2170 (Kyowa Hakko Kogyo).
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Lack of independent prognostic and predictive value of centromere 17 copy number changes in breast cancer patients with known HER2 and TOP2A status.
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Lanostanoids from Fungi: A Group of Potential Anticancer Compounds.
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Large-scale integration of microarray data reveals genes and pathways common to multiple cancer types.
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Leukemogenic rearrangements at the mixed lineage leukemia gene (MLL)-multiple rather than a single mechanism.
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Leukocyte 8-oxo-7,8-dihydro-2'-deoxyguanosine and comet assay in epirubicin-treated patients.
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Ligand Binding, Unbinding and Allosteric Effects: Deciphering Small-Molecule Modulation of HSP90.
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LncRNA SNHG3 promotes clear cell renal cell carcinoma proliferation and migration by upregulating TOP2A.
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Long non-coding RNAs in the doxorubicin resistance of cancer cells.
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Loss of BRG1 induces CRC cell senescence by regulating p53/p21 pathway.
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Loss of switch/sucrose non-fermenting complex protein expression is associated with dedifferentiation in endometrial carcinomas.
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Low expression of MRP1/GS-X pump ATPase in lymphocytes of Walker 256 tumour-bearing rats is associated with cyclopentenone prostaglandin accumulation and cancer immunodeficiency.
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Low-level TOP2A amplification in prostate cancer is associated with HER2 duplication, androgen resistance, and decreased survival.
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Lycobetaine acts as a selective topoisomerase II beta poison and inhibits the growth of human tumour cells.
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Lymphatic and blood vessel morphometry in invasive breast carcinomas: relation with proliferation and VEGF-C and -D proteins expression.
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Lymphocyte ATPase activity in patients with carcinoma of the larynx. A follow-up study on 45 patients.
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Mafosfamide induces DNA fragmentation and apoptosis in human T-lymphocytes. A possible mechanism of its immunosuppressive action.
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Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: evidence for genomic instability.
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Mammalian Chromatin Remodeling Complex SWI/SNF Is Essential for Enhanced Expression of the Albumin Gene during Liver Development.
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Mammalian protein homologous to VAT-1 of Torpedo californica: isolation from Ehrlich ascites tumor cells, biochemical characterization, and organization of its gene.
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Marinactinones A-C, new ?-pyrones from marine actinomycete Marinactinospora thermotolerans SCSIO 00606.
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Marked intratumoral heterogeneity of c-myc and cyclinD1 but not of c-erbB2 amplification in breast cancer.
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Markers for Sebaceoma Show a Spectrum of Cell Cycle Regulators, Tumor Suppressor Genes, and Oncogenes.
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Massive parallel DNA pyrosequencing analysis of the tumor suppressor BRG1/SMARCA4 in lung primary tumors.
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Maternal exposure to potential inhibitors of DNA topoisomerase II and infant leukemia (United States): a report from the Children's Cancer Group.
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Mcl-1 cleavage and sustained phosphorylation of c-Jun-N-terminal kinase mediate melanoma apoptosis induced by 2-acetyl furanonaphthoquinone: roles of Bcl-2 and p53.
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Mdm2 selectively suppresses DNA damage arising from inhibition of topoisomerase II independent of p53.
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Measurement of Drug-Stabilized Topoisomerase II Cleavage Complexes by Flow Cytometry.
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Measuring the Effect of Chemicals on the Growth and Reproduction of Caenorhabditis elegans.
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Mechanism and In Vitro Pharmacology of TAK1 Inhibition by (5Z)-7-Oxozeaenol.
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Mechanism of 201thallium-chloride uptake in tumor cells and its relationship to potassium channels.
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Mechanism of action and antitumor activity of (S)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7 H- pyridol[1,2,3-de]-[1,4]benzothiazine-6-carboxylic acid (WIN 58161).
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Mechanism of action of DNA topoisomerase inhibitors.
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Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme.
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Mechanism of action of key enzymes associated with cancer propagation and their inhibition by various chemotherapeutic agents.
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Mechanism of repair of 5'-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2.
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Mechanisms associated with cell adhesion mediated drug resistance (CAM-DR) in hematopoietic malignancies.
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Mechanisms of action of teniposide (VM-26) and comparison with etoposide (VP-16).
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Mechanisms of multidrug resistance in human tumor cells. The roles of P-glycoprotein, DNA topoisomerase II, and other factors.
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Mechanisms of resistance to drugs that inhibit DNA topoisomerases.
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Mechanisms regulating resistance to inhibitors of topoisomerase II.
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Megabase pair deletions in mutant mammalian cells following exposure to amsacrine, an inhibitor of DNA topoisomerase II.
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Merbarone induces activation of caspase-activated DNase and excision of chromosomal DNA loops from the nuclear matrix.
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Merkel cell carcinomas: expression of S-phase kinase-associated protein 2 (Skp2), p27, and proliferation markers.
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Mesenteric lymph reperfusion exacerbates spleen injury caused by superior mesenteric artery occlusion shock.
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Metabolic and non-metabolic pathways that control cancer resistance to anthracyclines.
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Mice with spontaneous mammary tumors develop type-specific neutralizing and cytotoxic antibodies against the mouse mammary tumor virus envelope protein gp52.
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Microsatellite status and cell cycle associated markers in rectal cancer patients undergoing a combined regimen of 5-FU and CPT-11 chemotherapy and radiotherapy.
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Millepachine, a potential topoisomerase II inhibitor induces apoptosis via activation of NF-?B pathway in ovarian cancer.
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MiR-599 targeting TOP2A inhibits the malignancy of bladder cancer cells.
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Mitochondria malfunctions as mediators of stem-cells' related carcinogenesis: a hypothesis that supports the highly conserved profile of carcinogenesis.
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Mitochondrial DNA somatic mutations (point mutations and large deletions) and mitochondrial DNA variants in human thyroid pathology: a study with emphasis on Hürthle cell tumors.
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Mitochondrial functional changes during hepatic hyperplasia and azo dye carcinogenesis.
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Mitosin and DNA topoisomerase IIalpha: two novel proliferation markers in the prognostication of diffuse astrocytoma patient survival.
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Mitotic bypass via an occult cell cycle phase following DNA topoisomerase II inhibition in p53 functional human tumor cells.
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MLL partner genes in secondary acute lymphoblastic leukemia: report of a new partner PRRC1 and review of the literature.
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Mms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase II.
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Model system for DNA replication of a plasmid DNA containing the autonomously replicating sequence from Saccharomyces cerevisiae.
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Modeling cancer genomic data in yeast reveals selection against ATM function during tumorigenesis.
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Modulation of DNA topoisomerase II alpha promoter activity by members of the Sp (specificity protein) and NF-Y (nuclear factor Y) families of transcription factors.
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Modulation of etoposide cytotoxicity and DNA strand scission in L1210 and 8226 cells by polyamines.
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Modulation of key regulators of mitosis linked to chromosomal instability is an early event in ochratoxin A carcinogenicity.
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Modulation of P-glycoprotein-Mediated Anticancer Drug Accumulation, Cytotoxicity, and ATPase Activity by Flavonoid Interactions.
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Modulation of S-100 genes response to growth conditions in human epithelial tumor cells.
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Modulatory effects of metformin on mutagenicity and epithelial tumor incidence in doxorubicin-treated Drosophila melanogaster.
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Molecular analysis of 13 cases of MLL/11q23 secondary acute leukemia and identification of topoisomerase II consensus-binding sequences near the chromosomal breakpoint of a secondary leukemia with the t(4;11).
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Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis.
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Molecular analysis of the topoisomerase II alpha gene and its expression in human ovarian cancer.
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Molecular and cellular interactions between intoplicine, DNA, and topoisomerase II studied by surface-enhanced Raman scattering spectroscopy.
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Molecular and Pharmacologic Properties of the Anticancer Quinolone Derivative Vosaroxin: A New Therapeutic Agent for Acute Myeloid Leukemia.
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Molecular basis of the interaction of novel tributyltin(IV) 2/4-[(E)-2-(aryl)-1-diazenyl]benzoates endowed with an improved cytotoxic profile: synthesis, structure, biological efficacy and QSAR studies.
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Molecular cytogenetic analysis in mouse sperm of chemically induced aneuploidy: studies with topoisomerase II inhibitors.
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Molecular differential analysis of uterine leiomyomas and leiomyosarcomas through weighted gene network and pathway tracing approaches.
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Molecular Dissection of 17q12 Amplicon in Upper Gastrointestinal Adenocarcinomas.
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Molecular dissection of 17q12 amplicon in upper gastrointestinal adenocarcinomas.
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Molecular Docking based analysis to elucidate the DNA Topoisomerase II? as the potential target for the Ganoderic acid, A natural therapeutic agent in cancer therapy.
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Molecular imaging: new applications for biochemistry.
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Molecular subtypes of breast cancer and amplification of topoisomerase II alpha: predictive role in dose intensive adjuvant chemotherapy.
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Molecular-guided therapy predictions reveal drug resistance phenotypes and treatment alternatives in malignant peripheral nerve sheath tumors.
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MORC3 Forms Nuclear Condensates through Phase Separation.
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mRNA expression of topoisomerase II in human tumors and normal tissues.
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Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray.
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Multidrug Resistance in Primary Tumors and Metastases in Patients with Esophageal Squamous Cell Carcinoma.
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Multidrug resistance protein and topoisomerase 2 alpha expression in non-small cell lung cancer are related with brain metastasis postoperatively.
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Multidrug resistance proteins and topoisomerase IIalpha expression in colon cancer: association with metastatic potential.
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Multidrug sensitivity phenotype of human lung cancer cells associated with topoisomerase II expression.
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Multidrug-resistant cancer cells contain two populations of P-glycoprotein with differently stimulated P-gp ATPase activities: evidence from atomic force microscopy and biochemical analysis.
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Multifactorial Approach to Predicting Resistance to Anthracyclines.
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Multifactorial involvement of multidrug resistance-associated [correction of resistance] protein, DNA topoisomerase II and glutathione/glutathione-S-transferase in nonP-glycoprotein-mediated multidrug resistance in human bladder cancer cells.
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Multiplatform profiling of meningioma provides molecular insight and prioritization of drug targets for rational clinical trial design.
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Multiple drug resistance parameter expression in ovarian cancer.
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Multiple gene expression analysis reveals distinct differences between G2 and G3 stage breast cancers, and correlations of PKC eta with MDR1, MRP and LRP gene expression.
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Multiple polysaccharide-drug complex-loaded liposomes: A unique strategy in drug loading and cancer targeting.
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Multiple Rad5 activities mediate sister chromatid recombination to bypass DNA damage at stalled replication forks.
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Multiplication of Chromosome 17 Centromere Is Associated with Prognosis in Patients with Invasive Breast Cancers Exhibiting Normal HER2 and TOP2A Status.
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Multispectroscopic methods reveal different modes of interaction of anti cancer drug mitoxantrone with Poly(dG-dC).Poly(dG-dC) and Poly(dA-dT).Poly(dA-dT).
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Mutation frequency and spectrum in lymphocytes of small cell lung cancer patients receiving etoposide chemotherapy.
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Mutation P732L in human DNA topoisomerase IIbeta abolishes DNA cleavage in the presence of calcium and confers drug resistance.
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Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution.
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Mutual regulation of MDM4 and TOP2A in cancer cell proliferation.
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MYC copy gain, chromosomal instability and PI3K activation as potential markers of unfavourable outcome in trastuzumab-treated patients with metastatic breast cancer.
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N-thioalkylcarbazoles derivatives as new anti-proliferative agents: synthesis, characterisation and molecular mechanism evaluation.
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Na+/K+ ATPase inhibitors in cancer.
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Naphthalene diimide-polyamine hybrids as antiproliferative agents: Focus on the architecture of the polyamine chains.
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Naphthalimides exhibit in vitro antiproliferative and antiangiogenic activities by inhibiting both topoisomerase II (topo II) and receptor tyrosine kinases (RTKs).
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NCX-4040, a Unique Nitric Oxide Donor, Induces Reversal of Drug-Resistance in Both ABCB1- and ABCG2-Expressing Multidrug Human Cancer Cells.
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Necroptosis induced by RIPK3 requires MLKL but not Drp1.
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New analogues of AHMA as potential antitumor agents: synthesis and biological activity.
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New aspects of cellular thallium uptake: Tl+-Na+-2Cl(-)-cotransport is the central mechanism of ion uptake.
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New benzoxanthone derivatives as topoisomerase inhibitors and DNA cross-linkers.
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New fluorescence-based high-throughput screening assay for small molecule inhibitors of tyrosyl-DNA phosphodiesterase 2 (TDP2).
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New insights into diagnosis and therapeutic options for proliferative hepatoblastoma.
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New insights into the mechanism of force generation by kinesin-5 molecular motors.
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New modulated design, docking and synthesis of carbohydrate-conjugate heterobimetallic CuII-SnIV complex as potential topoisomerase II inhibitor: in vitro DNA binding, cleavage and cytotoxicity against human cancer cell lines.
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New understanding of the role of anthracyclines in early-stage breast cancer: patient selection considerations.
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Nitric oxide inhibits ATPase activity and induces resistance to topoisomerase II-poisons in human MCF-7 breast tumor cells.
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Nitric oxide inhibits topoisomerase II activity and induces resistance to topoisomerase II-poisons in human tumor cells.
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Nitric oxide reverses drug resistance by inhibiting ATPase activity of p-glycoprotein in human multi-drug resistant cancer cells.
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NK314, a novel topoisomerase II inhibitor, induces rapid DNA double-strand breaks and exhibits superior antitumor effects against tumors resistant to other topoisomerase II inhibitors.
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NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform.
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Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction.
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Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II.
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Novel actions of inhibitors of DNA topoisomerase II in drug-resistant tumor cells.
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Novel carbamate analogues of amsacrine with activity against non-cycling murine and human tumour cells.
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Novel chemically modified oligonucleotides provide potent inhibition of P-glycoprotein expression.
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Novel Deazaflavin Analogues Potently Inhibited Tyrosyl DNA Phosphodiesterase 2 (TDP2) and Strongly Sensitized Cancer Cells toward Treatment with Topoisomerase II (TOP2) Poison Etoposide.
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Novel indolizino[8,7-b]indole hybrids as anti-small cell lung cancer agents: Regioselective modulation of topoisomerase II inhibitory and DNA crosslinking activities.
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Novel molecular markers of malignancy in histologically normal and benign breast.
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Novel tetra-acridine derivatives as dual inhibitors of topoisomerase II and the human proteasome.
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Nuclear factor-Y binding to the topoisomerase IIalpha promoter is inhibited by both the p53 tumor suppressor and anticancer drugs.
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Numerical analysis of etoposide induced DNA breaks.
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Obg-like ATPase 1 (OLA1) overexpression predicts poor prognosis and promotes tumor progression by regulating P21/CDK2 in hepatocellular carcinoma.
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Obg-like ATPase 1 inhibited oral carcinoma cell metastasis through TGF?/SMAD2 axis in vitro.
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OBG-like ATPase 1 inhibition attenuates angiotensin II-induced hypertrophic response in human ventricular myocytes via GSK-3beta/beta-catenin signalling.
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Obg-like ATPase 1 regulates global protein serine/threonine phosphorylation in cancer cells by suppressing the GSK3?-inhibitor 2-PP1 positive feedback loop.
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Observation of a Transient Reaction Intermediate Illuminates the Mechanochemical Cycle of the AAA-ATPase p97.
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Oestrogen potentiates topoisomerase-II-mediated cytotoxicity in an activated subpopulation of human breast cancer cells: implications for cytotoxic drug resistance in solid tumours.
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OLA1 is a potential prognostic molecular biomarker for endometrial cancer and promotes tumor progression.
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Oncocytic carcinoma of the salivary gland in a dog.
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Oncofetal HMGA2 attenuates genotoxic damage induced by topoisomerase II target compounds through the regulation of local DNA topology.
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Oncogene amplification in transforming myelodysplasia.
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Oncogenesis Caused by Loss of the SNF5 Tumor Suppressor Is Dependent on Activity of BRG1, the ATPase of the SWI/SNF Chromatin Remodeling Complex.
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Oncogenic potential of ATAD2 in stomach cancer and insights into the protein-protein interactions at its AAA?+?ATPase domain and bromodomain.
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Oncogenic Y-box binding protein-1 as an effective therapeutic target in drug-resistant cancer.
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Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide.
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Optimization of New Catalytic Topoisomerase II Inhibitors as an Anti-Cancer Therapy.
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Oral etoposide for recurrent/progressive sarcomas of childhood.
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Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells.
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Over-expression of TOP2A as a prognostic biomarker in patients with glioma.
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Over-Expression of Topoisomerase IIalpha is Related to the Grade of Cervical Intraepithelial Neoplasia (CIN) and High-Risk Human Papillomavirus (HPV), but does not Predict Prognosis in Cervical Cancer or HPV Clearance after Cone Treatment.
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Overexpression and role of the ATPase and putative DNA helicase RuvB-like 2 in human hepatocellular carcinoma.
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Overexpression of ATAD2 indicates Poor Prognosis in Oral Squamous Cell Carcinoma.
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Overexpression of Mitochondrial IF1 Prevents Metastatic Disease of Colorectal Cancer by Enhancing Anoikis and Tumor Infiltration of NK Cells.
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Overexpression of P-glycoprotein and alterations in topoisomerase II in P388 mouse leukemia cells selected in vivo for resistance to mitoxantrone.
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Overexpression of the ATPase Inhibitory Factor 1 Favors a Non-metastatic Phenotype in Breast Cancer.
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Overexpression of the BRIP1 ameliorates chemosensitivity to cisplatin by inhibiting Rac1 GTPase activity in cervical carcinoma HeLa cells.
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Overexpression of topoisomerase II alpha protein is a factor for poor prognosis in patients with luminal B breast cancer.
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Oxidative phosphorylation and ATPase activities of human tumor mitochondria.
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Oxygen uptake, ATPase activity, and superoxide dismutase activity in isolated rat liver mitochondria are not influenced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.
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p-53 gene mutations as a predictive marker in a population of advanced breast cancer patients randomly treated with doxorubicin or docetaxel in the context of a phase III clinical trial.
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P-glycoprotein effect on the properties of its natural lipid environment probed by Raman spectroscopy and Langmuir-Blodgett technique.
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P-glycoprotein expression and DNA topoisomerase I and II activity in benign tumors of the ovary and in malignant tumors of the ovary, before and after platinum/cyclophosphamide chemotherapy.
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P68 RNA helicase as a molecular target for cancer therapy.
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p97/VCP is highly expressed in the stem-like cells of breast cancer and controls cancer stemness partly through the unfolded protein response.
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Partial characterization of human leukemia U-937 cell sublines resistant to 9-nitrocamptothecin.
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Patterns and genomic correlates of PD-L1 expression in patients with biliary tract cancers.
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PGE2 and PGA2 affect the allosteric properties and the activities of calmodulin-dependent guanylate cyclase and Ca2+-stimulated ATPase of Walker-256 tumour microsomal membranes.
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Pharmacokinetic optimisation of treatment with oral etoposide.
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Pharmacokinetic study of cisplatin and infusional etoposide phosphate in advanced breast cancer with correlation of response to topoisomerase IIalpha expression.
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Pharmacokinetics and distribution of SN 28049, a novel DNA binding anticancer agent, in mice.
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Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity.
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Phase I and pharmacologic study of sequential topotecan, carboplatin, and etoposide.
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Phase I and pharmacologic study of sequential topotecan-carboplatin-etoposide in patients with extensive stage small cell lung cancer.
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Phase I Clinical Pharmacology Study of F14512, a New Polyamine-Vectorized Anticancer Drug, in Naturally Occurring Canine Lymphoma.
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Phase I dose-escalation study of F14512, a polyamine-vectorized topoisomerase II inhibitor, in patients with platinum-refractory or resistant ovarian cancer.
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Phase I evaluation of sequential topoisomerase targeting with irinotecan/cisplatin followed by etoposide in patients with advanced malignancy.
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Phase I study of tumor necrosis factor-alpha and actinomycin D in pediatric patients with cancer: a Children's Cancer Group study.
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Phase I trial of histone deacetylase inhibition by valproic acid followed by the topoisomerase II inhibitor epirubicin in advanced solid tumors: a clinical and translational study.
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Phase II multicenter trial of voreloxin as second-line therapy in chemotherapy-sensitive or refractory small cell lung cancer.
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Phase II study of taxol, merbarone, and piroxantrone in stage IV non-small-cell lung cancer: The Eastern Cooperative Oncology Group Results.
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Phenotypic characterization of BRCA1 and BRCA2 tumors based in a tissue microarray study with 37 immunohistochemical markers.
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Phenoxodiol (2H-1-benzopyran-7-0,1,3-(4-hydroxyphenyl)), a novel isoflavone derivative, inhibits DNA topoisomerase II by stabilizing the cleavable complex.
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Phorbol regulation of topoisomerases I and II in human leukemia cells. Studies in an additional cell pair sensitive or resistant to phorbol-induced differentiation.
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Phosphatase enzymes. Cytochemical study of pleomorphic adenoma and normal human salivary glands.
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Phosphorylation of DNA topoisomerase II in a human tumor cell line.
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Phosphorylation of Fas-associated death domain contributes to enhancement of etoposide-induced apoptosis in prostate cancer cells.
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Phosphorylation of the beta subunit of Na+K+-ATPase in Ehrlich ascites tumor by a membrane-bound protein kinase.
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Photosensitization of mitochondrial adenosine-triphosphatase and adenylate kinase by hematoporphyrin derivative in vitro.
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Phytochemical naphtho[1,2-b] furan-4,5?dione induced topoisomerase II-mediated DNA damage response in human non-small-cell lung cancer.
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Piceatannol, a stilbene phytochemical, inhibits mitochondrial F0F1-ATPase activity by targeting the F1 complex.
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Pleiotropic over-expression of multidrug-resistance-related genes is correlated to MYCN and max mRNA accumulation during tumour progression in the IGR-N-91 human neuroblastoma model.
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Podophyllotoxin analogs: effects on DNA topoisomerase II, tubulin polymerization, human tumor KB cells, and their VP-16-resistant variants.
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Polyketides from the marine-derived fungus Aspergillus falconensis: In silico and in vitro cytotoxicity studies.
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Polymorphisms in the MLL breakpoint cluster region (BCR).
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Positive response to neoadjuvant cyclophosphamide and doxorubicin in topoisomerase II nonamplified/HER2/neu negative/polysomy 17 absent breast cancer patients.
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Post-transcriptional regulation of the mitochondrial H(+)-ATP synthase: A key regulator of the metabolic phenotype in cancer.
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Potent Anti-Ovarian Cancer with Inhibitor Activities on both Topoisomerase II and V600EBRAF of Synthesized Substituted Estrone Candidates.
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Potential role for DNA topoisomerase II poisons in the generation of t(11;20)(p15;q11) translocations.
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Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties.
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Potentiation of etoposide-induced apoptosis by staurosporine in human tumor cells is associated with events downstream of DNA-protein complex formation.
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Potentiation of TNF-mediated cell killing by mitoxantrone. Relationship to DNA single-strand break formation.
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Potentiation of TNF-mediated cell killing by VP-16: relationship to DNA single-strand break formation.
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Potentiation of topoisomerase I and II inhibitors cell killing by tumor necrosis factor: relationship to DNA strand breakage formation.
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Potentiation of topoisomerase inhibitor-induced DNA strand breakage and cytotoxicity by tumor necrosis factor: enhancement of topoisomerase activity as a mechanism of potentiation.
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Potentiation of tumour necrosis factor-mediated cell killing by VP16 on human ovarian cancer cell lines. In vitro results and clinical implications.
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PRC2-mediated repression of SMARCA2 predicts EZH2 inhibitor activity in SWI/SNF mutant tumors.
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Preclinical Evaluation of Combined Topoisomerase and Proteasome Inhibition Against Pediatric Malignancies.
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Preclinical leads for innovative uses for etoposide.
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Predicting anthracycline benefit: have we made any progress?
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Predicting Anthracycline Benefit: TOP2A and CEP17-Not Only but Also.
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Prediction of ATPase cation transporting 13A2 molecule in Petromyzon marinus and pan-cancer analysis into human tumors from an evolutionary perspective.
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Prediction of new Hsp90 inhibitors based on 3,4-isoxazolediamide scaffold using QSAR study, molecular docking and molecular dynamic simulation.
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Predictive Biomarker Profiling of > 6000 Breast Cancer Patients Shows Heterogeneity in TNBC, With Treatment Implications.
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Predictive factors for anthracycline-based chemotherapy for human breast cancer.
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Predictive markers of anthracycline benefit: a prospectively planned analysis of the UK National Epirubicin Adjuvant Trial (NEAT/BR9601).
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Predictive value of apoptosis, proliferation, HER-2, and topoisomerase IIalpha for anthracycline chemotherapy in locally advanced breast cancer.
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Predictive value of HER-2 and Topoisomerase IIalpha in response to primary doxorubicin in breast cancer.
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Predictive value of topoisomerase II alpha immunostaining in urothelial bladder carcinoma.
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Predictive value of topoisomerase IIalpha and other prognostic factors for epirubicin chemotherapy in advanced breast cancer.
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Predisposition to therapy-related acute leukemia with balanced chromosomal translocations does not result from a major constitutive defect in DNA double-strand break end joining.
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Preferential induction of MLL(Mixed Lineage Leukemia) rearrangements in human lymphocyte cultures treated with etoposide.
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Preferential inhibition by quercetin of mitogen-stimulated thymocyte glucose transport.
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Preliminary experience with personalized and targeted therapy for pediatric brain tumors.
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Preliminary individual adjuvant chemotherapy for primary central nervous system lymphomas based on the expression of drug-resistance genes.
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Profiles of brain metastases: Prioritization of therapeutic targets.
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Prognosis-related molecular markers in pediatric central nervous system tumors.
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Prognostic and predictive value of the combination of TOP2A and HER2 in node-negative tumors 2 cm or smaller (T1N0) breast cancer.
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Prognostic effect of class III ?-tubulin and Topoisomerase-II in patients with advanced thymic carcinoma who received combination chemotherapy, including taxanes or topoisomerase-II inhibitors.
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Prognostic impact of KI67, p53, human epithelial growth factor receptor 2, topoisomerase IIalpha, epidermal growth factor receptor, and nm23 expression of ovarian carcinomas and disseminated tumor cells in the bone marrow.
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Prognostic markers of low-grade squamous intraepithelial lesions: the role of topoisomerase IIalpha and active caspase-3.
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Prognostic relevance of topoisomerase II ? and minichromosome maintenance protein 6 expression in colorectal cancer.
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Prognostic role of topoisomerase-IIalpha in advanced ovarian cancer patients.
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Prognostic significance of DNA topoisomerase IIalpha expression in human hepatocellular carcinoma. .
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Prognostic significance of Ki-67 and topoisomerase IIalpha expression in infiltrating ductal carcinoma of the breast. A multivariate analysis of 863 cases.
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Prognostic significance of sodium-potassium ATPase regulator, FXYD3, in human hepatocellular carcinoma.
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Prognostic Significance of TOP2A Gene Dosage in HER-2-Negative Breast Cancer.
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Prognostic significance of TOP2A in non-small cell lung cancer revealed by bioinformatic analysis.
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Prognostic significance of topoisomerase II alpha and collagen IV immunoexpression in cervical cancer.
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Prognostic Value and Significant Pathway Exploration Associated with TOP2A Involved in Papillary Thyroid Cancer.
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Prognostic value of ATAD3 gene cluster expression in hepatocellular carcinoma.
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Prognostic value of ATPase family, AAA+ domain containing 2 expression in human cancers: A systematic review and meta-analysis.
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Prognostic value of FHIT, CTNNB1, and MUC1 expression in non-small cell lung cancer.
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Prognostic value of immunohistochemical expression of topoisomerase alpha II, MIB-1, p53, E-cadherin, retinoblastoma gene protein product, and HER-2/neu in adrenal and extra-adrenal pheochromocytomas.
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Prognostic value of microsatellite instability determined by immunohistochemical staining of hMSH2 and hMSH6 in urothelial carcinoma of the bladder.
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Prognostic Value of TOP2A Gene Amplification and Chromosome 17 Polysomy in Early Breast Cancer.
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Prognostic value of TOP2A in bladder urothelial carcinoma and potential molecular mechanisms.
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Prognostic value of Topoisomerase II in female breast cancer.
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Prognostic Values of Filamin-A Status for Topoisomerase II Poison Chemotherapy.
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Prognostication of Soft Tissue Sarcomas Based on Chromosome 17q Gene and Protein Status: Evaluation of TOP2A, HER-2/neu, and Survivin.
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Proliferation and invasion of colon cancer cells are suppressed by knockdown of TOP2A.
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Prospects of Wedelolactone as a Chemotherapeutic Agent in Gynecological Cancers; Clue From its In-vitro and In-silico Investigation.
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Prostaglandin A1 inhibits stress-induced NF-kappaB activation and reverses resistance to topoisomerase II inhibitors.
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Prostatic origin of fucosyl transferase in human seminal plasma--a study on healthy controls and on men with infertility or with prostatic cancer.
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Protective effects of proanthocyanidins of grape (Vitis vinifera L.) seeds on DNA damage induced by Doxorubicin in somatic cells of Drosophila melanogaster.
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Protein expression and gene copy number analysis of topoisomerase 2alpha, HER2 and P53 in minimally invasive urothelial carcinoma of the urinary bladder--a multitissue array study with prognostic implications.
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Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours - A prognostic test after surgical resection.
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Protein tyrosine phosphatase activities are involved in apoptotic cancer cell death induced by GL331, a new homolog of etoposide.
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Proteins induced by DNA-damaging agents in cultured Drosophila cells.
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Proteolysis of the mismatch repair protein MLH1 by caspase-3 promotes DNA damage-induced apoptosis.
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Proteolytic Cleavage of the Linker Region of the Human P-glycoprotein Modulates Its ATPase Function.
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Proteomic analysis of infiltrating ductal carcinoma tissues by coupled 2-D DIGE/MS/MS analysis.
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Proteomic analysis of tumor tissue in CT-26 implanted BALB/C mouse after treatment with ascorbic acid.
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Proton pump inhibitors induce apoptosis of human B-cell tumors through a caspase-independent mechanism involving reactive oxygen species.
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Psammaplin A, a natural phenolic compound, has inhibitory effect on human topoisomerase II and is cytotoxic to cancer cells.
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Pulmonary tumor thrombotic microangiopathy from metastatic epithelioid angiosarcoma.
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Quantification and clinical relevance of gene amplification at chromosome 17q12-q21 in human epidermal growth factor receptor 2-amplified breast cancers.
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Quantitation of DNA topoisomerase II alpha messenger ribonucleic acid levels in a small cell lung cancer cell line and two drug resistant sublines using a polymerase chain reaction-aided transcript titration assay.
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Quantitative analysis of topoisomerase II alpha and evaluation of its effects on cell proliferation and apoptosis in glioblastoma cancer stem cells.
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Quantitative and qualitative aspects of topoisomerase I and II alpha and beta in untreated and platinum/cyclophosphamide treated malignant ovarian tumors.
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Quantitative aspects of chemical carcinogenesis and tumor promotion in liver.
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Quantitative microscopy of human DNA topoisomerase II-alpha expression in transitional cell carcinoma of the bladder.
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Quantum dot-based immunofluorescent imaging and quantitative detection of TOP2A and prognostic value in triple-negative breast cancer.
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R16, a novel amonafide analogue, induces apoptosis and G2-M arrest via poisoning topoisomerase II.
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Radiation enhancement by the combined use of topoisomerase I inhibitors, RFS-2000 or CPT-11, and topoisomerase II inhibitor etoposide in human lung cancer cells.
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Radiosensitizing effect of PSMC5, a 19S proteasome ATPase, in H460 lung cancer cells.
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RanBP2: a tumor suppressor with a new twist on TopoII, SUMO, and centromeres.
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Rapid inhibition of ongoing DNA synthesis in human glioma tissue by genistein.
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Ras stimulates DNA topoisomerase II alpha through MEK: a link between oncogenic signaling and a therapeutic target.
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Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1.
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Reactive oxygen species mediate the down-regulation of mitochondrial transcripts and proteins by tumour necrosis factor-alpha in L929 cells.
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Recent Advances in Use of Topoisomerase Inhibitors in Combination Cancer Therapy.
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Recurrent Glioblastomas Exhibit Higher Expression of Biomarkers with Stem-like Properties.
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Reduced expression of DNA topoisomerase II confers resistance to etoposide (VP-16) in small cell lung cancer cell lines established from a refractory tumor of a patient and by in vitro selection.
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Reduced topoisomerase II activity in multidrug-resistant human non-small cell lung cancer cell lines.
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Reduction of drug accumulation and DNA topoisomerase II activity in acquired teniposide-resistant human cancer KB cell lines.
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Regulation and repurposing of nutrient sensing and autophagy in innate immunity.
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Regulation by survivin of cancer cell death induced by F14512, a polyamine-containing inhibitor of DNA topoisomerase II.
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Regulation of apoptosis by androgens in prostate cancer cells.
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Regulation of conidiation and antagonistic properties of the soil-borne plant beneficial fungus Trichoderma virens by a novel proline-, glycine-, tyrosine-rich protein and a GPI-anchored cell wall protein.
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Regulation of DNA topoisomerases during cellular differentiation.
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Regulation of p38 phosphorylation and topoisomerase IIalpha expression in the B-cell lymphoma line Jiyoye by CD26/dipeptidyl peptidase IV is associated with enhanced in vitro and in vivo sensitivity to doxorubicin.
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Regulation of the mouse mammary tumor virus (MMTV) binding site in cultured mammary tissue.
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Regulation of topoisomerase II by murine mastocytoma cells.
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Regulation of topoisomerase II stability and activity by ubiquitination and SUMOylation: clinical implications for cancer chemotherapy.
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Regulation of tumor cell mitochondrial homeostasis by an organelle-specific hsp90 chaperone network.
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Related flavonoids cause cooperative inhibition of the sarcoplasmic reticulum Ca²? ATPase by multimode mechanisms.
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Relation of ETS transcription factor family member ERG, androgen receptor and topoisomerase 2? expression to TMPRSS2-ERG fusion status in prostate cancer.
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Relationship between expression of topoisomerase II isoforms and chemosensitivity in choroidal melanoma.
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Relationship between protein biomarkers of chemotherapy response and microsatellite status, tumor mutational burden, and PD-L1 expression in cancer patients.
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Relationship between Topoisomerase 2A RNA Expression and Recurrence after Adjuvant Chemotherapy for Breast Cancer.
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Relationship between topoisomerase II level and chemosensitivity in human tumor cell lines.
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Relationship of DNA damage signaling to DNA replication following treatment with DNA topoisomerase inhibitors camptothecin/topotecan, mitoxantrone, or etoposide.
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Relationships between rhodamine 123 transport, cell volume, and ion-channel function of P-glycoprotein.
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Relative molecular similarity in selected chemical carcinogens and the nucleoside triphosphate chain.
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Repair of topoisomerase-mediated DNA damage in bacteriophage T4.
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Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancer.
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Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation.
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Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II.
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Resistance of mammalian tumor cells to inhibitors of DNA topoisomerase II.
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Resistance to etoposide in human leukemia HL-60 cells: reduction in drug-induced DNA cleavage associated with hypophosphorylation of topoisomerase II phosphopeptides.
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Resolution and reconstitution of biological pathways from 1919 to 1984.
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Response to epirubicin in patients with superficial bladder cancer and expression of the topoisomerase II alpha and beta genes.
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Restoration of Topoisomerase 2 Function by Complementation of Defective Monomers in Drosophila.
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Restricted-Expressed Proliferation-Associated Protein (Repp86) Expression in Squamous Cell Carcinoma of the Oral Cavity.
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Rethinking medulloblastoma from a targeted therapeutics perspective.
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retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group.
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Reversal of physiological stress-induced resistance to topoisomerase II inhibitors using an inducible phosphorylation site-deficient mutant of I kappa B alpha.
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Ribosomal protein S11 influences glioma response to TOP2 poisons.
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RNAi analysis reveals an unexpected role for topoisomerase II in chromosome arm congression to a metaphase plate.
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Role of an inverted CCAAT element in human topoisomerase IIalpha gene expression in ICRF-187-sensitive and -resistant CEM leukemic cells.
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Role of heat treatment in childhood cancers: distinct resistance profiles of solid tumor cell lines towards combined thermochemotherapy.
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Role of Pd(II)-chitooligosaccharides-Gboxin analog in oxidative phosphorylation inhibition and energy depletion: Targeting mitochondrial dynamics.
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Role of radiotherapy and chemotherapy in the risk of leukemia after childhood cancer: An international pooled analysis.
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Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells.
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Role of Topoisomerases in Pediatric High Grade Osteosarcomas: TOP2A Gene Is One of the Unique Molecular Biomarkers of Chemoresponse.
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RUNX1-MTG16 fusion gene in acute myeloblastic leukemia with t(16;21)(q24;q22): case report and review of the literature.
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RUVBL1-ITFG1 interaction is required for collective invasion in breast cancer.
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RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer.
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Salinomycin-Loaded Iron Oxide Nanoparticles for Glioblastoma Therapy.
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Salt-stable binding of the large T protein to DNA in polyoma virus chromatin.
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Salvicine triggers DNA double-strand breaks and apoptosis by GSH-depletion-driven H2O2 generation and topoisomerase II inhibition.
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Salvicine, a novel topoisomerase II inhibitor, exerts its potent anticancer activity by ROS generation.
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SCF?-TrCP-mediated degradation of TOP2? promotes cancer cell survival in response to chemotherapeutic drugs targeting topoisomerase II.
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Screening and identification of genes associated with cell proliferation in cholangiocarcinoma.
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Secondary acute myeloid leukemia in a child treated for retinoblastoma: A case report with review of literature.
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Secondary acute promyelocytic leukemia following chemotherapy for non-Hodgkin's lymphoma in a child.
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Secondary ALL after Successful Treatment of Ewing's Sarcoma: A Case Report.
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Secondary osteosarcoma in patients previously treated for childhood cancer: Three case reports.
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Secreted heat shock protein-90 (Hsp90) in wound healing and cancer.
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Selection of cancer chemopreventive agents based on inhibition of topoisomerase II activity.
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Semi-synthetic isoflavones as BACE-1 inhibitors against Alzheimer's disease.
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Separation and identification of HSP-associated protein complexes from pancreatic cancer cell lines using 2D CN/SDS-PAGE coupled with mass spectrometry.
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Sequential hepatic histologic and histochemical changes produced by diethylnitrosamine in the rhesus monkey.
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Sequestration of AS-DACA into Acidic Compartments of the Membrane Trafficking System as a Mechanism of Drug Resistance in Rhabdomyosarcoma.
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Serial topoisomerase II expression in primary breast cancer and response to neoadjuvant anthracycline-based chemotherapy.
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Serine 1524 is a major site of phosphorylation on human topoisomerase II alpha protein in vivo and is a substrate for casein kinase II in vitro.
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Serologic analysis of ovarian tumor antigens reveals a bias toward antigens encoded on 17q.
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Serum and hepatic enzyme activity in rats treated with diethylnitrosamine.
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Severe hypoxia induces complete antifolate resistance in carcinoma cells due to cell cycle arrest.
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Signatures of Adverse Pathological Features, Androgen Insensitivity and Metastatic Potential in Prostate Cancer.
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Silencing of ATPase family AAA domain-containing protein 2 inhibits migration and invasion of colorectal cancer cells.
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Simultaneous amplification of HER-2 (ERBB2) and topoisomerase IIalpha (TOP2A) genes--molecular basis for combination chemotherapy in cancer.
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Simultaneous detection of TOP2A and HER2 gene amplification by multiplex ligation-dependent probe amplification in breast cancer.
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Simultaneous quantitation of topoisomerase II alpha and beta isoform mRNAs in lung tumor cells and normal and malignant lung tissue.
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Single-strand conformational polymorphism analysis of the M(r) 170,000 isozyme of DNA topoisomerase II in human tumor cells.
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Singular v dual inhibition of SNF2L and its isoform, SNF2LT, have similar effects on DNA damage but opposite effects on the DNA damage response, cancer cell growth arrest and apoptosis.
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SKP2 confers resistance of pancreatic cancer cells towards TRAIL-induced apoptosis.
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Small-molecule inhibitors targeting eIF4A in leukemia.
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Sodium orthovanadate overcomes sorafenib resistance of hepatocellular carcinoma cells by inhibiting Na+/K+-ATPase activity and hypoxia-inducible pathways.
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Solution structure and dynamics of a complex between DNA and the antitumor bisnaphthalimide LU-79553: intercalated ring flipping on the millisecond time scale.
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Somatic Mutations and Intratumoral Heterogeneity of MYH11 Gene in Gastric and Colorectal Cancers.
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SOX4 and SMARCA4 cooperatively regulate PI3k signaling through transcriptional activation of TGFBR2.
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Soy and breast cancer: focus on angiogenesis.
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SPDEF inhibits prostate carcinogenesis by disrupting a positive feedback loop in regulation of the Foxm1 oncogene.
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STEALTH liposomal CKD-602, a topoisomerase II inhibitor, improves the therapeutic index in human tumor xenograft models.
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Stereo (C7)-dependent topoisomerase II inhibition and tumor growth suppression by a new quinolone, BO-2367.
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Stimulation of the topoisomerase II induced DNA cleavage sites in the c-myc protooncogene by antitumor drugs is associated with gene expression.
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Strategies to circumvent multidrug resistance due to P-glycoprotein or to altered DNA topoisomerase II.
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Strategy of the scientific committee on occupational exposure limits (SCOEL) in the derivation of occupational exposure limits for carcinogens and mutagens.
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Streptonigrin-induced topoisomerase II sites exhibit base preferences in the middle of the enzyme stagger.
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Structural organization of the human TOP2A and TOP2B genes.
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Structural Recognition and Binding Pattern Analysis of Human Topoisomerase II Alpha with Steroidal Drugs: In Silico Study to Switchover the Cancer Treatment.
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Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasome.
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Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms.
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Structure-guided optimization of 4,6-substituted-1,3,5-triazin-2(1H)-ones as catalytic inhibitors of human DNA topoisomerase II?.
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STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion.
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Subcellular distribution of the alpha and beta topoisomerase II-DNA complexes stabilized by VM-26.
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Subcellular localization and cellular pharmacokinetics of MX2, a new morpholino anthracycline in glioma cells using confocal laser scanning microscopy.
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Subependymal giant cell astrocytoma: a clinicopathological study of 23 cases with special emphasis on proliferative markers and expression of p53 and retinoblastoma gene proteins.
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Subpopulations of Langerhans' cells in cervical neoplasia.
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Substituted 4,5'-Bithiazoles as Catalytic Inhibitors of Human DNA Topoisomerase II?.
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Substituted purine analogues define a novel structural class of catalytic topoisomerase II inhibitors.
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Suppression of ATAD2 inhibits hepatocellular carcinoma progression through activation of p53- and p38-mediated apoptotic signaling.
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Suppression of topoisomerase IIalpha expression and function in human cells decreases chromosomal radiosensitivity.
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Suramin inhibits the phosphorylation and catalytic activity of DNA topoisomerase II in human lung cancer cells.
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SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.
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SY 03-3 OVERVIEW OF SOMATIC MUTATIONS AND EPIGENETIC REGULATION OF ALDOSTERONE PRODUCING ADENOMA (APA).
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Synchronous rectal and gastric cancer in a fighter pilot: aeromedical concerns.
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Synergistic antitumor effects of topoisomerase inhibitors and natural cell-mediated cytotoxicity.
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Synergistic enhancement by tumor necrosis factor of in vitro cytotoxicity from chemotherapeutic drugs targeted at DNA topoisomerase II.
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Synergistic inhibition of human cancer cell growth by cytotoxic drugs and mixed backbone antisense oligonucleotide targeting protein kinase A.
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Synergistic interaction between histone deacetylase and topoisomerase II inhibitors is mediated through topoisomerase IIbeta.
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Synergistic interaction of proteasome and topoisomerase II inhibition in multiple myeloma.
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Synthesis and anticancer activities of 6-amino amonafide derivatives.
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Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives. Part 2.
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Synthesis and antiproliferative evaluation of certain indolo[3,2-c]quinoline derivatives.
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Synthesis and antitumor activity of 5-(9-acridinylamino)anisidine derivatives.
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Synthesis and biological activity of 2,4-di-p-phenolyl-6-2-furanyl-pyridine as a potent topoisomerase II poison.
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Synthesis and biological evaluation of histone deacetylase and DNA topoisomerase II-Targeted inhibitors.
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Synthesis and biological evaluation of new derivatives of emodin.
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Synthesis and biological evaluation of novel carbazole-rhodanine conjugates as topoisomerase II inhibitors.
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Synthesis and Biological Evaluation of Novel Ursolic acid Derivatives as Potential Anticancer Prodrugs.
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Synthesis and biological study of a new series of 4'-demethylepipodophyllotoxin derivatives.
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Synthesis and evaluation of (18)F-labeled ATP competitive inhibitors of topoisomerase II as probes for imaging topoisomerase II expression.
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Synthesis and evaluation of new salicylaldehyde-2-picolinylhydrazone Schiff base compounds of Ru(II), Rh(III) and Ir(III) as in vitro antitumor, antibacterial and fluorescence imaging agents.
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Synthesis and evaluation of novel ellipticines as potential anti-cancer agents.
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Synthesis and in vitro screening of phenylbipyridinylpyrazole derivatives as potential antiproliferative agents.
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Synthesis and in-vitro cytotoxicity evaluation of gatifloxacin Mannich bases.
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Synthesis and Mechanism Studies of 1,3-Benzoazolyl Substituted Pyrrolo[2,3-b]pyrazine Derivatives as Nonintercalative Topoisomerase II Catalytic Inhibitors.
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Synthesis of 1-/2-substituted-[1,2,3]triazolo[4,5-g]phthalazine-4,9-diones and evaluation of their cytotoxicity and topoisomerase II inhibition.
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Synthesis of 4?-N-polyaromatic substituted podophyllotoxins: DNA topoisomerase inhibition, anticancer and apoptosis-inducing activities.
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Synthesis of podophyllotoxin congeners as potential DNA topoisomerase II inhibitors.
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Synthesis, Activity, and Pharmacophore Development for Isatin-beta-thiosemicarbazones with Selective Activity toward Multidrug-Resistant Cells.
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Synthesis, cytotoxic activity, DNA topoisomerase-II inhibition, molecular modeling and structure-activity relationship of 9-anilinothiazolo[5,4-b]quinoline derivatives.
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Synthesis, cytotoxicity, and DNA topoisomerase II inhibitory activity of benzofuroquinolinediones.
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Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer.
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Systems Biomedicine of Primary and Metastatic Colorectal Cancer Reveals Potential Therapeutic Targets.
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t(11;16)(q23;p13)/KMT2A-CREBBP in hematologic malignancies: presumptive evidence of myelodysplasia or therapy-related neoplasm?
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T-cell acute lymphoblastic leukemia as a secondary leukemia after a 3-year remission of acute myelocytic leukemia.
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Tamoxifen is a Na(+)-antagonistic inhibitor of Na+/K(+)-transporting ATPase from tumour and normal cells.
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Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer.
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Targeted Luminescent Probes for Precise Upconversion/NIR II Luminescence Diagnosis of Lung Adenocarcinoma.
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Targeted methylation facilitates DNA double strand breaks and enhances cancer suppression: A DNA intercalating/methylating dual-action chimera Amonafidazene.
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Targeting DNA topoisomerase II in cancer chemotherapy.
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Targeting DNA-PK in cancer.
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Targeting Hsp90 in Non-Cancerous Maladies.
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Targeting of topoisomerases for prognosis and drug resistance in ovarian cancer.
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Targeting Proteasomal Pathways by Dietary Curcumin for Cancer Prevention and Treatment.
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Targeting the cytotoxicity of topoisomerase II-directed epipodophyllotoxins to tumor cells in acidic environments.
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Targeting the inverted CCAAT box 2 in the topoisomerase IIalpha promoter by JH-37, an imidazole-pyrrole polyamide hairpin: design, synthesis, molecular biology, and biophysical studies.
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Targeting Topoisomerase II Activity in NSCLC with 9-Aminoacridine Derivatives.
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Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer.
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Teniposide induces nuclear but not mitochondrial DNA degradation.
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Thallium-201 uptake, histopathological differentiation and Na-K ATPase in lung adenocarcinoma.
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The ability of biomarkers to predict systemic progression in men with high-risk prostate cancer treated surgically is dependent on ERG status.
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The activity of topoisomerases is related to the grade and stage in human renal cell carcinoma.
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The antitumor drug F14512 enhances cisplatin and ionizing radiation effects in head and neck squamous carcinoma cell lines.
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The association between the p53/topoisomerase I and p53/ topoisomerase IIalpha immunophenotypes and the progression of ovarian carcinomas.
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The ATAD2 Bromodomain Binds Different Acetylation Marks on the Histone H4 in Similar Fuzzy Complexes.
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The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination.
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The ATPase activity of reptin is required for its effects on tumor cell growth and viability in hepatocellular carcinoma.
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The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth.
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The ATPase VCP Is a Druggable Target for Cancer Therapy.
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The BRG1 ATPase of human SWI/SNF chromatin remodeling enzymes as a driver of cancer.
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The catalytic topoisomerase II inhibitor dexrazoxane induces DNA breaks, ATF3 and the DNA damage response in cancer cells.
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The cell cycle phases of DNA damage and repair initiated by topoisomerase II-targeting chemotherapeutic drugs.
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The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1.
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The clinicopathological and prognostic significance of membrane type 1 matrix metalloproteinase (MT1-MMP) and MMP-9 according to their localization in invasive breast carcinoma.
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The conserved core enzymatic activities and the distinct dynamics of polyomavirus large T antigens.
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The Crabtree effect: a new look at the old problem.
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The cytochrome b5 tail anchors and stabilizes subdomains of human DNA topoisomerase II alpha in the cytoplasm of retrovirally infected mammalian cells.
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The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells.
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The discovery and optimization of novel dual inhibitors of topoisomerase ii and histone deacetylase.
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The distribution and expression of the two isoforms of DNA topoisomerase II in normal and neoplastic human tissues.
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The distribution of immunoreactive topoisomerase II Protein in human tissues and neoplasms.
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The DNA binding polyamine moiety in the vectorized DNA topoisomerase II inhibitor F14512 alters reparability of the consequent enzyme-linked DNA double strand breaks.
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The effect of multidrug resistance modulator HZ08 on pharmacodynamics and pharmacokinetics of adriamycin in xenograft-nude mice.
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The expression of the SWI/SNF ATPase subunits BRG1 and BRM in normal human tissues.
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The expression of transforming growth factor-alpha in cirrhosis, dysplastic nodules, and hepatocellular carcinoma: an immunohistochemical study of 70 cases.
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The FLT3 inhibitor midostaurin selectively resensitizes ABCB1-overexpressing multidrug-resistant cancer cells to conventional chemotherapeutic agents.
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The genetic depletion or the triptolide inhibition of TFIIH in p53-deficient cells induces a JNK-dependent cell death in Drosophila.
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The Golgi calcium pump secretory pathway calcium ATPase 1 (SPCA1) is a key regulator of insulin-like growth factor receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231.
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The HSP90 molecular chaperone - an enigmatic ATPase.
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The impact of therapy-related acute myeloid leukemia (AML) on outcome in 2853 adult patients with newly diagnosed AML.
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The important molecular markers on chromosome 17 and their clinical impact in breast cancer.
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The incidence of topoisomerase II-alpha genomic alterations in adenocarcinoma of the breast and their relationship to human epidermal growth factor receptor-2 gene amplification: a fluorescence in situ hybridization study.
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The influence of DNA methylation on topoisomerase II activity and its possible link with genomic instability in different cell lines of the syrian hamster.
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The influence of hyaluronan-CD44 interaction on topoisomerase II activity and etoposide cytotoxicity in head and neck cancer.
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The Interplay of Cofactor Interactions and Post-translational Modifications in the Regulation of the AAA+ ATPase p97.
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The investigational new drug XK469 induces G(2)-M cell cycle arrest by p53-dependent and -independent pathways.
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The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomerase IIalpha in breast cancer cells.
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The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.
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The measurement of nuclear topoisomerase II inhibition in vitro: a possible tool for detecting resistance on a subcellular level in haematopoietic malignancies.
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The modulating effect of retinoids and a tumor promoter on malignant transformation, sister chromatid exchanges, and Na/K ATPase.
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The p270 (ARID1A/SMARCF1) subunit of mammalian SWI/SNF-related complexes is essential for normal cell cycle arrest.
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The p53 gene in pediatric therapy-related leukemia and myelodysplasia.
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The p53 tumor suppressor stimulates the catalytic activity of human topoisomerase IIalpha by enhancing the rate of ATP hydrolysis.
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The Pathological Response to Anthracycline is Associated with Topoisomerase II? Gene Amplification in the HER2 Breast Cancer Subset.
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The plant diterpene epoxysiderol targets Hsp70 in cancer cells, affecting its ATPase activity and reducing its translocation to plasma membrane.
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The potential mechanism of chemosensitive difference between 2 types of ovarian cancer.
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The preclinical discovery of vosaroxin for the treatment of acute myeloid leukemia.
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The predictors of response to neoadjuvant chemotherapy in patients with locally advanced gastric cancer.
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The prognostic significance of proliferative activity, apoptosis and expression of DNA topoisomerase II alpha in multimodally-treated oesophageal squamous cell carcinoma.
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The prognostic significance of topoisomerase II alpha protein in early stage luminal breast cancer.
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The ras oncogene-mediated sensitization of human cells to topoisomerase II inhibitor-induced apoptosis.
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The related miRNAs involved in doxorubicin resistance or sensitivity of various cancers: an update.
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The relative contribution of CHK1 and CHK2 to Adriamycin-induced checkpoint.
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The resistance of esophageal cancer cells to paclitaxel can be reduced by the knockdown of long noncoding RNA DDX11-AS1 through TAF1/TOP2A inhibition.
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The reversible epigenetic silencing of BRM: implications for clinical targeted therapy.
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The role of ATPase in glycolysis of Ehrlich ascites tumor cells.
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The role of telomeres in Etoposide induced tumor cell death.
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The SET and transposase domain protein Metnase enhances chromosome decatenation: regulation by automethylation.
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The significance of the sequence of administration of topotecan and etoposide.
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The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies.
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The soluble metal-binding domain of the copper transporter ATP7B binds and detoxifies cisplatin.
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The steroidal Na+/K+ ATPase inhibitor 3-[(R)-3-pyrrolidinyl]oxime derivative (3-R-POD) induces potent pro-apoptotic responses in colonic tumor cells.
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The structure and function of NKAIN2-a candidate tumor suppressor.
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The Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage.
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The SUMO-targeted ubiquitin ligase RNF4 localizes to etoposide-exposed mitotic chromosomes: Implication for a novel DNA damage response during mitosis.
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The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation.
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The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription-replication conflicts.
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The topoisomerase II inhibitor teniposide (VM-26) induces apoptosis in unstimulated mature murine lymphocytes.
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The Use of Methods of Computer-Aided Drug Discovery in the Development of Topoisomerase II Inhibitors: Applications and Future Directions.
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The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma.
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The value of TOP2A gene copy number variation as a biomarker in breast cancer: Update of DBCG trial 89D.
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The yeast tumor suppressor homologue Sro7p is required for targeting of the sodium pumping ATPase to the cell surface.
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Therapeutic strategies in male breast cancer: Clinical implications of chromosome 17 gene alterations and molecular subtypes.
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Therapeutic Targeting of Nuclear Export Inhibition in Lung Cancer.
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Therapy-associated lymphoid proliferations.
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Therapy-related acute lymphoblastic leukaemia with MLL rearrangements following DNA topoisomerase II inhibitors, an increasing problem: report on two new cases and review of the literature since 1992.
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Therapy-related acute myelogenous leukemia associated with 11q23 chromosomal abnormalities and topoisomerase II inhibitors: report of four additional cases and brief commentary.
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Therapy-related acute promyelocytic leukemia: a report on 16 cases.
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Therapy-related acute promyelocytic leukemia: a systematic review.
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Therapy-related leukemia and myelodysplastic syndrome: a large-scale Japanese study of clinical and cytogenetic features as well as prognostic factors.
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Therapy-related leukemia following chemoradiotherapy for esophageal cancer.
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Thyroid Hormone Receptor ? Suppression of RUNX2 Is Mediated by Brahma-Related Gene 1-Dependent Chromatin Remodeling.
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TIMP-1 in combination with HER2 and TOP2A for prediction of benefit from adjuvant anthracyclines in high-risk breast cancer patients.
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Tirapazamine: a hypoxia-activated topoisomerase II poison.
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Tissue distribution of the cellular binding protein for the mouse mammary tumour virus.
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TNMplot.com: A Web Tool for the Comparison of Gene Expression in Normal, Tumor and Metastatic Tissues.
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Tobacco mosaic virus delivery of mitoxantrone for cancer therapy.
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TOP2A Amplification and Overexpression in Hepatocellular Carcinoma Tissues.
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TOP2A amplification in breast cancer is a predictive marker of anthracycline-based neoadjuvant chemotherapy efficacy.
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TOP2A and HER2 gene amplification as predictors of response to anthracycline treatment in breast cancer.
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TOP2A copy number and TOP2A expression in uterine benign smooth muscle tumours and leiomyosarcoma.
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TOP2A gene copy gain predicts response of epithelial ovarian cancers to pegylated liposomal doxorubicin: TOP2A as marker of response to PLD in ovarian cancer.
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Top2a identifies and provides epigenetic rationale for novel combination therapeutic strategies for aggressive prostate cancer.
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TOP2A induces malignant character of pancreatic cancer through activating ?-catenin signaling pathway.
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TOP2A is overexpressed and a therapeutic target for adrenocortical carcinoma.
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TOP2A overexpression as a poor prognostic factor in patients with nasopharyngeal carcinoma.
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TOP2A overexpression in hepatocellular carcinoma correlates with early age onset, shorter patients survival and chemoresistance.
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TOP2A Promotes Lung Adenocarcinoma Cells' Malignant Progression and Predicts Poor Prognosis in Lung Adenocarcinoma.
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TOP2A, GGH, and PECAM1 are associated with hematogenous, lymph node, and peritoneal recurrence in stage II/III gastric cancer patients enrolled in the ACTS-GC study.
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TOPOIIalpha and HER-2/neu overexpression/amplification in Barrett's oesophagus, dysplasia and adenocarcinoma.
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Topoisomerase 2 Alpha Cooperates with Androgen Receptor to Contribute to Prostate Cancer Progression.
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Topoisomerase 2? and thymidylate synthase expression in adrenocortical cancer.
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Topoisomerase 2A gene amplification in breast cancer. Critical evaluation of different FISH probes.
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Topoisomerase expression and amplification in solid tumours: Analysis of 24,262 patients.
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Topoisomerase expression in cancer cell lines and clinical samples.
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Topoisomerase II alpha amplification may predict benefit from adjuvant anthracyclines in HER2 positive early breast cancer.
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Topoisomerase II alpha and beta in human tumor cells grown in vitro and in vivo.
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Topoisomerase II alpha and responsiveness of breast cancer to adjuvant chemotherapy.
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Topoisomerase II alpha and telomerase expression in papillary thyroid carcinomas.
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Topoisomerase II alpha as a marker predicting anthracyclines' activity in early breast cancer patients: ready for the primetime?
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Topoisomerase II alpha as a marker predicting the efficacy of anthracyclines in breast cancer: are we at the end of the beginning?
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Topoisomerase II alpha as a universal tumor antigen: antitumor immunity in murine tumor models and H-2K(b)-restricted T cell epitope.
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Topoisomerase II alpha co-amplification with erbB2 in human primary breast cancer and breast cancer cell lines: relationship to m-AMSA and mitoxantrone sensitivity.
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Topoisomerase II alpha expression and the Ki-67 labeling index correlate with prognostic factors in estrogen receptor-positive and human epidermal growth factor type-2-negative breast cancer.
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Topoisomerase II alpha expression correlates with diminished disease-free survival in invasive breast cancer.
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Topoisomerase II alpha expression in acute myeloid leukaemia and its relationship to clinical outcome.
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Topoisomerase II alpha expression in esophageal squamous cell carcinoma.
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Topoisomerase II alpha expression in squamous cell carcinomas of the head and neck.
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Topoisomerase II alpha expression in testicular germ cell tumors.
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Topoisomerase II alpha gene copy loss has adverse prognostic significance in ERBB2-amplified breast cancer: a retrospective study of paraffin-embedded tumor specimens and medical charts.
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Topoisomerase II alpha mRNA and tumour cell proliferation in non-Hodgkin's lymphoma.
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Topoisomerase II alpha promoter trans-activation early in monocytic differentiation of HL-60 human leukemia cells.
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Topoisomerase II alpha promotes gallbladder cancer proliferation and metastasis through activating phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway.
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Topoisomerase II alpha status in renal medullary carcinoma: immuno-expression and gene copy alterations of a potential target of therapy.
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Topoisomerase II alpha--a fundamental prognostic factor in breast carcinoma.
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Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice.
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Topoisomerase II gene mutations in tumors and tumor cell lines with microsatellite instability.
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Topoisomerase II immunostaining as a prognostic marker for survival in ovarian cancer.
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Topoisomerase II inhibition and altered kinetics of formation and repair of nitrosourea and cisplatin-induced DNA interstrand cross-links and cytotoxicity in human glioblastoma cells.
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Topoisomerase II inhibition and cytotoxicity of the anthrapyrazoles DuP 937 and DuP 941 (Losoxantrone) in the National Cancer Institute preclinical antitumor drug discovery screen.
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Topoisomerase II inhibition suppresses the proliferation of telomerase-negative cancers.
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Topoisomerase II inhibitors from the roots of Stellera chamaejasme L.
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Topoisomerase II is regulated by translationally controlled tumor protein for cell survival during organ growth in Drosophila.
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Topoisomerase II is required for mitoxantrone to signal nuclear factor kappa B activation in HL60 cells.
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Topoisomerase II levels and drug response in small cell lung cancer.
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Topoisomerase II poisoning and antineoplastic action by DNA-nonbinding diacetyl and dicarboxaldoxime derivatives of ferrocene.
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Topoisomerase II poisoning by indazole and imidazole complexes of ruthenium.
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Topoisomerase II SUMOylation activates a metaphase checkpoint via Haspin and Aurora B kinases.
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Topoisomerase II-alfa gene as a predictive marker of response to anthracyclines in breast cancer.
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Topoisomerase II-alpha (topoII) and HER2 amplification in breast cancers and response to preoperative doxorubicin chemotherapy.
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Topoisomerase II-alpha expression in different cell cycle phases in fresh human breast carcinomas.
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Topoisomerase II-alpha expression in melanocytic nevi and malignant melanoma.
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Topoisomerase II-alpha gene deletion is not frequent as its amplification in breast cancer.
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Topoisomerase II-mediated DNA cleavage activity induced by ellipticines on the human tumor cell line N417.
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Topoisomerase II? and its role in different biological contexts.
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Topoisomerase II? in chromosome instability and personalized cancer therapy.
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Topoisomerase IIa protein expression analysis in oral squamous cell carcinoma.
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Topoisomerase IIalpha and other drug resistance markers in advanced non-small cell lung cancer.
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Topoisomerase IIalpha expression in breast cancer: correlation with outcome variables.
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Topoisomerase IIalpha expression in mantle cell lymphoma: a marker of cell proliferation and a prognostic factor for clinical outcome.
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Topoisomerase IIalpha expression in pituitary adenomas and carcinomas: relationship to tumor behavior.
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Topoisomerase IIalpha gene (TOP2A) amplification and deletion in cancer--more common than anticipated.
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Topoisomerase IIalpha gene amplification predicts favorable treatment response to tailored and dose-escalated anthracycline-based adjuvant chemotherapy in HER-2/neu-amplified breast cancer: Scandinavian Breast Group Trial 9401.
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Topoisomerase IIalpha gene expression is regulated by the p53 tumor suppressor gene in nonsmall cell lung carcinoma patients.
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Topoisomerase IIalpha gene status and prediction of pathological complete remission after anthracycline-based neoadjuvant chemotherapy in endocrine non-responsive Her2/neu-positive breast cancer.
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Topoisomerase IIalpha in Wilms' tumour: gene alterations and immunoexpression.
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Topoisomerase IIalpha-positive and BRCA1-negative phenotype: association with favorable response to epirubicin-based regimens for human breast cancers.
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Topoisomerase II{alpha} amplification does not predict benefit from dose-intense cyclophosphamide, doxorubicin, and fluorouracil therapy in HER2-amplified early breast cancer: results of CALGB 8541/150013.
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Topoisomerase II{alpha}-dependent and -independent apoptotic effects of dexrazoxane and doxorubicin.
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Topoisomerase inhibitors. A review of their therapeutic potential in cancer.
Neoplasms
Topoisomerase-1 and -2A gene copy numbers are elevated in mismatch repair-proficient colorectal cancers.
Neoplasms
Topoisomerase-II activity in human leukemic and lymphoblastoid cells.
Neoplasms
Topoisomerase-II alpha is upregulated in malignant peripheral nerve sheath tumors and associated with clinical outcome.
Neoplasms
Topotecan increases topoisomerase IIalpha levels and sensitivity to treatment with etoposide in schedule-dependent process.
Neoplasms
Toxicity of the topoisomerase II inhibitors.
Neoplasms
Toxicological evaluation of the topoisomerase inhibitor, etoposide, in the model animal Caenorhabditis elegans and 3T3-L1 normal murine cells.
Neoplasms
Transcription factor c-Jun activation represses mdr-1 gene expression.
Neoplasms
Transcription-induced DNA double strand breaks: both an oncogenic force and potential therapeutic target?
Neoplasms
Translational Control of TOP2A Influences Doxorubicin Efficacy.
Neoplasms
Transmission of an Mls-1a-like superantigen to BALB/c mice by foster-nursing on F1 Mls-1bxa mothers. Sex-influenced onset of clonal deletion.
Neoplasms
Treatment-related myelodysplasia in patients with primary brain tumors.
Neoplasms
Triazoloacridone C-1305 abrogates the restriction checkpoint in cells lacking functional p53 and promotes their accumulation in the G2/M phase of the cell cycle.
Neoplasms
TRIP13 promotes the proliferation and invasion of lung cancer cells via the Wnt signaling pathway and epithelial-mesenchymal transition.
Neoplasms
Triple negative breast cancer--current status and prospective targeted treatment based on HER1 (EGFR), TOP2A and C-MYC gene assessment.
Neoplasms
Triple negative breast cancer: molecular profiling and prognostic impact in adjuvant anthracycline-treated patients.
Neoplasms
Trk inhibitor attenuates the BDNF/TrkB-induced protection of neuroblastoma cells from etoposide in vitro and in vivo.
Neoplasms
Tumor cell resistance to DNA topoisomerase II inhibitors: new developments.
Neoplasms
Tumor cell resistance to topoisomerase II poisons: role for intracellular free calcium in the sensitization by inhibitors or calcium-calmodulin-dependent enzymes.
Neoplasms
Tumor heterogeneity at protein level as an independent prognostic factor in endometrial cancer.
Neoplasms
Tumor necrosis factor and chemotherapeutic drugs targeted at DNA topoisomerase II for the treatment of genitourinary malignancies.
Neoplasms
Tumor necrosis factor enhances the in vitro and in vivo efficacy of chemotherapeutic drugs targeted at DNA topoisomerase II in the treatment of murine bladder cancer.
Neoplasms
Tumor necrosis factor receptor 1 is an ATPase regulated by silencer of death domain.
Neoplasms
Tumor p53 status and response to topoisomerase II inhibitors.
Neoplasms
Tumor rejection antigen gp96/grp94 is an ATPase: implications for protein folding and antigen presentation.
Neoplasms
Tumor Topoisomerase II Alpha Status and Response to Anthracycline-Based Neoadjuvant Chemotherapy in Breast Cancer.
Neoplasms
Tumor- and stromal cell-specific expression of topoisomerase II? and HER-2/neu in primary and recurrent ovarian cancer: Results of a prospective study.
Neoplasms
Tumor-necrosis-factor and DNA topoisomerase-ii inhibitors in human ovarian-cancer - potential role in chemotherapy.
Neoplasms
Tumour promoter tert-butyl-hydroperoxide induces peroxynitrite formation in human erythrocytes.
Neoplasms
Tumour tissue selectivity in the uptake and retention of SN 28049, a new topoisomerase II-directed anticancer agent.
Neoplasms
Tumour Topoisomerase II Alpha Protein Expression and Outcome After Adjuvant Dose-Dense Anthracycline-Based Chemotherapy.
Neoplasms
Turn up the cellular power generator with vitamin E analogue formulation.
Neoplasms
Two-Mechanism Model for the Interaction of Etoposide Quinone with Topoisomerase II?.
Neoplasms
Ultracytochemistry of the cell surface and microfilaments in dimethylhydrazine-induced colonic tumor cells.
Neoplasms
Ultrastructural cytochemistry of phosphatases in the ductal component of pleomorphic adenoma of human parotid and submandibular salivary glands.
Neoplasms
Unidirectional fluxes of rhodamine 123 in multidrug-resistant cells: evidence against direct drug extrusion from the plasma membrane.
Neoplasms
Unlike other chemicals, etoposide (a topoisomerase-II inhibitor) produces peak mutagenicity in primary spermatocytes of the mouse.
Neoplasms
Unravelling the Antiproliferative Activity of 1,2,5-oxadiazole Derivatives.
Neoplasms
Up-regulation of caveolae and caveolar constituents in multidrug-resistant cancer cells.
Neoplasms
Up-regulation of the ATPase inhibitory factor 1 (IF1) of the mitochondrial H+-ATP synthase in human tumors mediates the metabolic shift of cancer cells to a Warburg phenotype.
Neoplasms
UP12, a novel ursolic acid derivative with potential for targeting multiple signaling pathways in hepatocellular carcinoma.
Neoplasms
Upregulation of both heme oxygenase-1 and ATPase inhibitory factor 1 renders tumoricidal activity by synthetic flavonoids via depleting cellular ATP.
Neoplasms
Urothelial carcinoma of the bladder with abundant myxoid stroma: A case report and literature review.
Neoplasms
Using specific cytotoxics with a targeted mind.
Neoplasms
Utilization of fluorescence in situ hybridization with cytokeratin discriminators in TOP2A assessment of chemotherapy-treated patients with breast cancer.
Neoplasms
Vacuolar H(+)-ATPase signaling pathway in cancer.
Neoplasms
Valproic acid induces p21 and topoisomerase-II (alpha/beta) expression and synergistically enhances etoposide cytotoxicity in human glioblastoma cell lines.
Neoplasms
Value of topoisomerase II alpha, MIB-1, p53, E-cadherin, retinoblastoma gene protein product, and HER-2/neu immunohistochemical expression for the prediction of biologic behavior in adrenocortical neoplasms.
Neoplasms
Value of urinary topoisomerase-IIA cell-free DNA for diagnosis of bladder cancer.
Neoplasms
Vanadate is toxic to adherent- growing multidrug-resistant cells.
Neoplasms
Variable ATPase composition of human tumor plasma membranes.
Neoplasms
Virtual prototyping study shows increased ATPase activity of Hsp90 to be the key determinant of cancer phenotype.
Neoplasms
Whole genome expression profiling shows that BRG1 transcriptionally regulates UV inducible genes and other novel targets in human cells.
Neoplasms
Whole-transcriptomic Profile of SK-MEL-3 Melanoma Cells Treated with the Histone Deacetylase Inhibitor: Trichostatin A.
Neoplasms
Why do tumor cells have a high aerobic glycolysis?
Neoplasms
WLS/wntless is essential in controlling dendritic cell homeostasis via a WNT signaling-independent mechanism.
Neoplasms
WRN protects against topo I but not topo II inhibitors by preventing DNA break formation.
Neoplasms
XK469, a selective topoisomerase IIbeta poison.
Neoplasms
Zhankuic Acids A, B and C from Taiwanofungus Camphoratus Act as Cytotoxicity Enhancers by Regulating P-Glycoprotein in Multi-Drug Resistant Cancer Cells.
Neoplasms
Zinc protects against tumor necrosis factor-induced disruption of porcine endothelial cell monolayer integrity.
Neoplasms
[A preliminary study to determine the activity of topoisomerase II in human kidney cancer cells with DNA unknotting method]
Neoplasms
[Abnormality of TOP2A expression and its gene copy number variations in neuroblastic tumors].
Neoplasms
[Adenylate system of rat liver tissue during chemical carcinogenesis]
Neoplasms
[Anthracycline-induced cardiotoxicity]
Neoplasms
[ATPase and 5-nucleotidase in human breast and stomach tumors]
Neoplasms
[ATPase and AMPase activity in the mitochondria of two ascitic tumors: ascites hepatoma of the rat and Ehrlich ascites tumor.]
Neoplasms
[Chromosome translocations and leukemias induced by inhibitors of topoisomerase II anticarcinogenic drugs]
Neoplasms
[Clinical pathological characteristics of 4 cases of gastric gland-derived tumors].
Neoplasms
[Comparative study of Coptidis Rhizoma and Aconiti Kusnezoffii Radix on cell differentiation in lewis lung cancer].
Neoplasms
[Correlation between aneuploidy of chromosome 17, over-expression of TP53 and TOPIIalpha, and the clinicopathological features and diagnosis of gastric adenocarcinoma]
Neoplasms
[Correlation of the expression of MDR genes and MDR genes-coded product with prognosis in laryngopharyngeal malignant melanoma]
Neoplasms
[Difference in 201TlCl accumulation mechanism in brain tumors: a comparison of their Na(+)-K+ ATPase activities]
Neoplasms
[EFFECT OF CORTISONE INJECTIONS ON THE CONTENT OF ATP AND ADP AND ON THE ATPASE ACTIVITY OF ASCITES TUMOR CELLS.]
Neoplasms
[Effect of irradiation on the ATPase activity of the nuclei and mitochondria of ascitic tumor cells]
Neoplasms
[Effect on mouse S180 MDR tumour cell expression correlated factorial matter by 70% ethanol with Huanglian Jiedu Tang]
Neoplasms
[Electron-microscopic histochemistry of phosphohydrolases in the normal mucosa and in the cells of human gastric adenocarcinoma]
Neoplasms
[Epigenetic effects affecting etoposide distribution and metabolism in the human body].
Neoplasms
[Evaluation of malignancy of squamous cell lung cancer by clinico-morphological, immunohistochemical and prognostic study of tumor markers]
Neoplasms
[Expression and significance of MRP, GST-pi, Topo IIalpha, and LRP in gastric carcinoma]
Neoplasms
[Expression and significance of P-glycoprotein, glutathione S-transferase-pi and Topoisomerase II in gastric carcinomas]
Neoplasms
[Expression of ATPase inhibitory factor 1 in normal and pathological tissues of female reproductive system].
Neoplasms
[Expression of glutathione S-transferase-pi and DNA topoisomerase II alpha and their implications in colorectal carcinoma]
Neoplasms
[Expression of individual proteins of mouse mammary gland cancer virus in tumors in mice of various strains]
Neoplasms
[Expression of P-gp, GST-pi and Topo IIalpha in gastric and colorectal cancers and their clinical significance.]
Neoplasms
[Expression of topoisomerase II alpha in human colorectal carcinoma and its significance.]
Neoplasms
[Expression of topoisomerase IIalpha in nasopharyngeal carcinoma and its clinical significance]
Neoplasms
[HCO3-sensitive adenosinetriphosphatase from ascites tumour cells]
Neoplasms
[HCO3-stimulated adenosine triphosphatase in rat ovarian tumor cells]
Neoplasms
[HER-2 and TOP 2A gene amplifications in urinary bladder carcinoma]
Neoplasms
[Histochemical demonstration of glial enzyme activity. II. Reagent and neoplastic glia]
Neoplasms
[Histogenesis of giant cell tumors of bone. comparative, ultrastructural and histo-enzymologic study of osteoforming tumors and malignant and giant cell tumors]
Neoplasms
[Immunohistochemical evaluation of intracranial recurrent meningiomas: correlation of topoisomerase II alpha expression and cell proliferative potential]
Neoplasms
[Immunohistochemical evaluation of topoisomerase IIalpha as proliferation factor in gastric lymphoma]
Neoplasms
[Inhibition of bladder cancer cell growth and angiogenesis by co-blockage of vascular endothelial growth factor and its receptor kdr]
Neoplasms
[Level of cyclic nucleotides (cAMP and cGMP), ATPase activity and calcium ion transport in hamster lymphocytes during tumor growth]
Neoplasms
[Markers of effectiveness of preoperative taxane-based chemotherapy for locally advanced breast cancer].
Neoplasms
[Modifying effect of ionizing radiation on the transmembrane transport of sodium ions in Ehrlich carcinoma tumor cells]
Neoplasms
[Multiple trichoepitheliomas, cylindromas and milia. An entity]
Neoplasms
[Multivariate analysis of the parameters related to recurrence of laryngeal papilloma in adult]
Neoplasms
[Non-neurogenic activators of myocyte contraction and their role in the realization of the accumulative-evacuating functions of the urinary bladder].
Neoplasms
[Predictive molecular marker of distant metastasis in colorectal cancer]
Neoplasms
[Purification and biochemical characteristics of myosin from rat malignant sarcoma-45]
Neoplasms
[Report of two cases with germinoma treated by individual adjuvant chemotherapy based on the mRNA expression of drug-resistance gene]
Neoplasms
[Role of intestinal lymphatic in myocardial injury in rats receiving hemorrhage and lipopolysaccharide challenge]
Neoplasms
[Role of phospholipids, ATPase and pH in the calcification mechanism of neoplasms during combined dihydromonocalcium phosphate and x-ray irradiation treatment]
Neoplasms
[Secondary leukemias: their clinical features, incidence among populations at risk, mechanisms and new strategy for prediction]
Neoplasms
[Some peculiarities of ATPase in tumor mitochondria]
Neoplasms
[Studies of multidrug resistance gene expression and apoptosis in stomach carcinoma]
Neoplasms
[Study of matrine's use on the reversion of obtained multi-drug resistance of mice S80 tumour cell]
Neoplasms
[Study on ATPase of tumor cells--I. A comparison of several ATPase activities]
Neoplasms
[The effect of matrine on the expression of P170 LRP and TOPO II of obtained multi-drug resistance of mouse S180's tumour cell]
Neoplasms
[The effect of tetrandrine on the expression of the P170, LRP and TOPO II in S180's tumor cell induced by chemotherapy in the mice with acquired multi-drug resistance]
Neoplasms
[The effect of topoisomerase II inhibitor, vepesid, on binding of doxorubicin with DNA in tumor cells sensitive to anthracycline]
Neoplasms
[The interference in correlated molecular mechanism obtained multi-drug resistance of mouse S180's tumour cell for different alkaloid]
Neoplasms
[The relationship between abnormal MDR gene expression and chemotherapy response in lymphoid malignancies]
Neoplasms
[The role of stromal components and Ca++ ATPase in pleomorphic adenoma and adenoid cystic carcinoma]
Neoplasms
[Therapy-related acute leukemia: study of 23 pacients.]
Neoplasms
[Topoisomerase IIa expression in correlation with clinical and morphological parameters and proliferation (based on argyrophilic proteins of nucleolar organizer regions and Ki-67 antigen) in lung adenocarcinoma].
Neoplasms
[Topoisomerase IIalpha activity and tumor cell proliferation level from the degree of bromodeoxyuridine label in uterine body leiomyosarcoma].
Neoplasms
[Topoisomerase IIalpha and HER2/neu gene alterations and their correlation in pancreatic ductal adenocarcinomas]
Neoplasms
[Tumor biology of primary breast cancer and minimal residual disease]
Neoplasms
[Ultracytochemical study of the nucleoside phosphatase activity of nuclei of epithelial cells of the gastric mucosa and of stomach cancer cells in humans]
Neoplasms, Germ Cell and Embryonal
DNA topoisomerase I and II expression in drug resistant germ cell tumours.
Neoplasms, Germ Cell and Embryonal
Immunohistochemical and two-parameter flow cytometric studies of DNA topoisomerase II alpha in human epithelial ovarian carcinoma and germ cell tumor.
Neoplasms, Germ Cell and Embryonal
Mutation frequency and spectrum in lymphocytes of small cell lung cancer patients receiving etoposide chemotherapy.
Neoplasms, Germ Cell and Embryonal
The potential mechanism of chemosensitive difference between 2 types of ovarian cancer.
Neoplasms, Germ Cell and Embryonal
Topoisomerase II alpha expression in testicular germ cell tumors.
Neoplasms, Germ Cell and Embryonal
[Report of two cases with germinoma treated by individual adjuvant chemotherapy based on the mRNA expression of drug-resistance gene]
Neoplasms, Glandular and Epithelial
Topoisomerase II alpha: prognostic predictor and cell cycle marker in surface epithelial neoplasms of the ovary and peritoneum.
Neoplasms, Neuroepithelial
Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity.
Neoplasms, Second Primary
Inhibition of topoisomerase II in 32D.3(G) cells by hydroquinone is associated with cell death.
Neoplasms, Second Primary
International Commission for Protection Against Environmental Mutagens and Carcinogens. Mutagenicity and carcinogenicity of topoisomerase-interactive agents.
Neoplasms, Second Primary
Oral etoposide for recurrent/progressive sarcomas of childhood.
Neoplasms, Second Primary
Secondary acute myeloid leukemia in a child treated for retinoblastoma: A case report with review of literature.
Neoplasms, Second Primary
t(11;16)(q23;p13)/KMT2A-CREBBP in hematologic malignancies: presumptive evidence of myelodysplasia or therapy-related neoplasm?
Neoplasms, Second Primary
[Second cancers associated with the cancer treatment and their possible control]
Neoplasms, Squamous Cell
[Evaluation of malignancy of squamous cell lung cancer by clinico-morphological, immunohistochemical and prognostic study of tumor markers]
Nephritis, Interstitial
Expression of DNA topoisomerases in chronic proliferative kidney disease.
Nephrolithiasis
Chronic low level trimethyltin exposure and the risk of developing nephrolithiasis.
Nephrolithiasis
[Lipid peroxidation and Ca-dependent ATPase activity in the microsomal fraction of renal tissue in patients with nephrolithiasis and chronic pyelonephritis]
Nephrosis
Decreased ATPase activity in adriamycin nephrosis is independent of proteinuria.
Nervous System Diseases
Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers.
Nervous System Diseases
Mutation of the mitochrondrially encoded ATPase 6 gene modeled in the ATP synthase of Escherichia coli.
Nervous System Diseases
Schizoid neurochemical pathology-induced membrane Na(+)-K+ ATPase inhibition in relation to neurological disorders.
Nervous System Neoplasms
Treatment-related myelodysplasia in patients with primary brain tumors.
Neuralgia
Peripheral nerve injury induces persistent vascular dysfunction and endoneurial hypoxia, contributing to the genesis of neuropathic pain.
Neuroblastoma
A study of the topoisomerase II activity in HIV-1 replication using the ferrocene derivatives as probes.
Neuroblastoma
Adriamycin promotes neurite outgrowth in the "neurite-minus" N1A-103 mouse neuroblastoma cell line.
Neuroblastoma
ATPase activity of neuroblastoma cells in culture.
Neuroblastoma
Bilirubin toxicity in a neuroblastoma cell line N-115: I. Effects on Na+K+ ATPase, [3H]-thymidine uptake, L-[35S]-methionine incorporation, and mitochondrial function.
Neuroblastoma
BIRICODAR (VX-710; Incel): an effective chemosensitizer in neuroblastoma.
Neuroblastoma
Ca-2+-activated ATPase at the external surface of neuroblastoma cells in culture.
Neuroblastoma
Chromatin remodelling at the topoisomerase II-beta promoter is associated with enhanced sensitivity to etoposide in human neuroblastoma cell lines.
Neuroblastoma
Distinct roles of Topoisomerase II isoforms: DNA damage accelerating alpha, double strand break repair promoting beta.
Neuroblastoma
Dual inhibition of MAGL and type II topoisomerase by N-phenylmaleimides as a potential strategy to reduce neuroblastoma cell growth.
Neuroblastoma
Effect of lithium on the membrane-bound magnesium-dependent ATPase of mouse neuroblastoma cells.
Neuroblastoma
Epigallocatechin gallate inhibits sphere formation of neuroblastoma BE(2)-C cells.
Neuroblastoma
Epolactaene, a novel neuritogenic compound in human neuroblastoma cells, selectively inhibits the activities of mammalian DNA polymerases and human DNA topoisomerase II.
Neuroblastoma
Expression analysis of multidrug resistance associated genes in neuroblastomas.
Neuroblastoma
High-resolution array CGH profiling identifies Na/K transporting ATPase interacting 2 (NKAIN2) as a predisposing candidate gene in neuroblastoma.
Neuroblastoma
Neuroblastoma and treatment-related myelodysplasia/leukemia: the Memorial Sloan-Kettering experience and a literature review.
Neuroblastoma
Poly (ADP-ribose) polymerase induction is an early signal of apoptosis in human neuroblastoma.
Neuroblastoma
Regulation of topoisomerase II alpha and beta in HIV-1 infected and uninfected neuroblastoma and astrocytoma cells: involvement of distinct nordihydroguaretic acid sensitive inflammatory pathways.
Neuroblastoma
TG2 protects neuroblastoma cells against DNA-damage-induced stress, suppresses p53 activation.
Neuroblastoma
The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1.
Neuroblastoma
The effects of trimethyltin on the Ca+2, Mg+2 and Ca+2 + Mg+2-dependent ATPases of human neuroblastoma GM 3320.
Neuroblastoma
Translocations of 17q21 approximately qter in neuroblastoma cell lines infrequently include the topoisomerase IIalpha gene.
Neuroblastoma
[Demonstration of an ATPase sensitive to ouabain on the external surface of the cells of neuroblastomas and of glial cells in culture]
Neuroblastoma
[Proceedings: AtPase activity of C1 300 neuroblastoma cells in culture]
Neuroblastoma
[Study of ATPase (Na+, K+) activity in cultured neuroblastoma cells]
Neurodegenerative Diseases
ATPase activity of p97/valosin-containing protein is regulated by oxidative modification of the evolutionally conserved cysteine 522 residue in Walker A motif.
Neurodegenerative Diseases
Drosophila Valosin-Containing Protein is required for dendrite pruning through a regulatory role in mRNA metabolism.
Neurodegenerative Diseases
Mutations in the Human AAA(+) Chaperone p97 and Related Diseases.
Neurodegenerative Diseases
Polyamine Transport Assay Using Reconstituted Yeast Membranes.
Neurodegenerative Diseases
Prediction of ATPase cation transporting 13A2 molecule in Petromyzon marinus and pan-cancer analysis into human tumors from an evolutionary perspective.
Neurodegenerative Diseases
The T9176G mtDNA mutation severely affects ATP production and results in Leigh syndrome.
Neurodegenerative Diseases
[A challenge for revealing common molecular mechanisms underlying neurodegenerative disorders]
Neuroectodermal Tumors, Primitive
Gene Expression Signatures Identify Novel Therapeutics for Metastatic Pancreatic Neuroendocrine Tumors.
Neurofibroma
Expression and inhibition of BRD4, EZH2 and TOP2A in neurofibromas and malignant peripheral nerve sheath tumors.
Neurofibroma
Topoisomerase-II alpha is upregulated in malignant peripheral nerve sheath tumors and associated with clinical outcome.
Neurofibroma, Plexiform
Expression and inhibition of BRD4, EZH2 and TOP2A in neurofibromas and malignant peripheral nerve sheath tumors.
Neurofibroma, Plexiform
Molecular profiling of malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1, based on large-scale real-time RT-PCR.
Neurofibromatoses
Acute myeloid leukaemia in children.
Neurofibrosarcoma
Expression and inhibition of BRD4, EZH2 and TOP2A in neurofibromas and malignant peripheral nerve sheath tumors.
Neurofibrosarcoma
Genomic and molecular aberrations in malignant peripheral nerve sheath tumor and their roles in personalized target therapy.
Neurofibrosarcoma
Identification of a novel amplicon at distal 17q containing the BIRC5/SURVIVIN gene in malignant peripheral nerve sheath tumours.
Neurofibrosarcoma
Molecular-guided therapy predictions reveal drug resistance phenotypes and treatment alternatives in malignant peripheral nerve sheath tumors.
Neurofibrosarcoma
Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours - A prognostic test after surgical resection.
Neurofibrosarcoma
Systemic Options for Malignant Peripheral Nerve Sheath Tumors.
Neurofibrosarcoma
Topoisomerase-II alpha is upregulated in malignant peripheral nerve sheath tumors and associated with clinical outcome.
Neuroinflammatory Diseases
Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates.
Neuromuscular Diseases
The Caenorhabditis elegans polarity gene ooc-5 encodes a Torsin-related protein of the AAA ATPase superfamily.
Neuromuscular Diseases
[Histochemistry of skeletal muscle ATPase in neuromuscular diseases, with special reference to progressive muscular dystrophy]
Neuronal Ceroid-Lipofuscinoses
Novel interactions of CLN3 protein link Batten disease to dysregulation of fodrin-Na+, K+ ATPase complex.
Neutropenia
Acute myeloid leukaemia in children.
Neutropenia
An Open-Label, Dose-Escalating Phase I Study of Elsamitrucin (SPI 28090) in Treatment of Malignant Solid Tumors in Dogs.
Neutropenia
Camptothecin and Podophyllotoxin Derivatives : Inhibitors of Topoisomerase I and II - Mechanisms of Action, Pharmacokinetics and Toxicity Profile.
Neutropenia
Effect of TOP2A and ERCC1 gene polymorphisms on the efficacy and toxicity of cisplatin and etoposide-based chemotherapy in small cell lung cancer patients.
Neutropenia
Phase I trial of irinotecan and amrubicin with granulocyte colony-stimulating factor support in extensive-stage small-cell lung cancer.
Nevus
INO80 governs superenhancer-mediated oncogenic transcription and tumor growth in melanoma.
Nevus
Molecular classification of melanoma using real-time quantitative reverse transcriptase-polymerase chain reaction.
Nevus
The immunohistochemical profile of Spitz nevi and conventional (non-Spitzoid) melanomas: a baseline study.
Nevus
Topoisomerase II-alpha expression in melanocytic nevi and malignant melanoma.
Nevus, Pigmented
Enhanced expression of Ki-67, topoisomerase IIalpha, PCNA, p53 and p21WAF1/Cip1 reflecting proliferation and repair activity in UV-irradiated melanocytic nevi.
Nevus, Pigmented
Topoisomerase II-alpha expression in melanocytic nevi and malignant melanoma.
Newcastle Disease
Fusion factor and ATPase in a strain of Newcastle disease virus in different hosts.
Non-alcoholic Fatty Liver Disease
Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction.
Obesity
A reproducible procedure for measuring sodium transport in cultured human fibroblasts from normal and obese donors.
Obesity
Catecholamine-stimulated potassium transport in erythrocytes from normal and obese subjects.
Obesity
Changes of ATPase activities in erythrocytes of rats with hypothalamic obesity.
Obesity
Hepatic sodium-potassium-dependent ATPase in obesity.
Obesity
Increased leucocyte Na-K ATPase in obesity: reversal following weight loss.
Obesity
Increased leucocyte Na.K ATPase in obesity: reversal following weight loss.
Obesity
Protective Effect of Gymnema sylvestre Ethanol Extract on High Fat Diet-induced Obese Diabetic Wistar Rats.
Obesity
Regulation of Na+/K+-ATPase by Estradiol and IGF-1 in Cardio-Metabolic Diseases.
Obesity
Spectrophotometric assay of renal ouabain-resistant Na(+)-ATPase and its regulation by leptin and dietary-induced obesity.
Obesity
[Clinical studies on assay for Na-K ATPase in human blood cells. I. Erythrocyte Na-K ATPase assay in patients with thyroid dysfunction and in those with chronic renal failure]
Obesity
[New data on characteristics of the chemism of erythrocytes in patients with metabolic-alimentary obesity]
Odontogenic Cysts
Odontogenic keratocysts: a clinical and histological study with special reference to enzyme histochemistry.
Oligodendroglioma
Expression of cyclin A and topoisomerase IIalpha of oligodendrogliomas is correlated with tumour grade, MIB-1 labelling index and survival.
Oligodendroglioma
Expression of DNA topoisomerase IIalpha in oligodendroglioma.
Oligodendroglioma
High topoisomerase IIalpha expression associates with high proliferation rate and and poor prognosis in oligodendrogliomas.
Oligospermia
Analysis of ejaculates from patients with cystic fibrosis.
Oligospermia
[Eosin Y-sensitive ATPase activity in men's spermatozoids as a biochemical test for oligozoospermia]
Oliguria
Pathophysiology of acute renal failure following living Escherichia coli injection in rats: high-energy metabolism and renal functions.
Oncogene Addiction
Oncogenesis Caused by Loss of the SNF5 Tumor Suppressor Is Dependent on Activity of BRG1, the ATPase of the SWI/SNF Chromatin Remodeling Complex.
Ophthalmoplegia
Hereditary inclusion-body myopathies.
Opportunistic Infections
Reduced Langerhans' cell Ia antigen and ATPase activity in patients with the acquired immunodeficiency syndrome.
Optic Atrophy
Identification of a Dynamic Mitochondrial Protein Complex Driving Cholesterol Import, Trafficking, and Metabolism to Steroid Hormones.
Optic Atrophy
Mitochondrial regulation of macrophage cholesterol homeostasis.
Optic Atrophy, Autosomal Dominant
Drosophila ADCK1 is critical for maintaining mitochondrial structures and functions in the muscle.
Optic Atrophy, Autosomal Dominant
Identification of a Dynamic Mitochondrial Protein Complex Driving Cholesterol Import, Trafficking, and Metabolism to Steroid Hormones.
Optic Atrophy, Autosomal Dominant
Mitochondrial regulation of macrophage cholesterol homeostasis.
Optic Atrophy, Hereditary, Leber
PRICKLE3 linked to ATPase biogenesis manifested Leber's hereditary optic neuropathy.
Optic Nerve Diseases
ATPase Domain AFG3L2 Mutations Alter OPA1 Processing and Cause Optic Neuropathy.
Optic Nerve Diseases
PRICKLE3 linked to ATPase biogenesis manifested Leber's hereditary optic neuropathy.
Oropharyngeal Neoplasms
Evaluation of pemetrexed and etoposide as therapeutic regimens for human papillomavirus-positive oral and oropharyngeal cancer.
Osteitis Deformans
Altered cofactor regulation with disease-associated p97/VCP mutations.
Osteitis Deformans
Enhanced ATPase activities as a primary defect of mutant valosin-containing proteins that cause inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia.
Osteitis Deformans
The N-terminal Region of the Ubiquitin Regulatory X (UBX) Domain-containing Protein 1 (UBXD1) Modulates Interdomain Communication within the Valosin-containing Protein p97.
Osteitis Deformans
The Role of the N-Domain in the ATPase Activity of the Mammalian AAA ATPase p97/VCP.
Osteoarthritis
Histochemical discrimination of HLA-DR positive cell populations in the normal and arthritic synovial lining.
Osteoblastoma
Enhancement of ornithine decarboxylase and Na+, K+ ATPase in osteoblastoma cells by intermittent compression.
Osteomalacia
Calcium ATPase activity in drug-induced osteomalacia.
Osteomyelitis
[Ciprofloxacin in Salmonella infection and abdominal typhoid]
Osteopetrosis
Molecular and cellular basis of lysosomal transmembrane protein dysfunction.
Osteopetrosis
Novel mutations in the TCIRG1 gene encoding the a3 subunit of the vacuolar proton pump in patients affected by infantile malignant osteopetrosis.
Osteoporosis
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Osteoporosis
V-type ATPase proton pump expression during enamel formation.
Osteoporosis
[Basic results of an experiment with mammals on the Kosmos-782 biosatellite]
Osteosarcoma
A high affinity, calmodulin-responsive (Ca2+ + Mg2+)-ATPase in isolated bone cells.
Osteosarcoma
A novel deficiency of mitochondrial ATPase of nuclear origin.
Osteosarcoma
Additive effect of adenovirus-mediated E2F-1 gene transfer and topoisomerase II inhibitors on apoptosis in human osteosarcoma cells.
Osteosarcoma
AHA1 upregulates IDH1 and metabolic activity to promote growth and metastasis and predicts prognosis in osteosarcoma.
Osteosarcoma
Development of acute myeloid leukemia after chemotherapy for osteosarcoma.
Osteosarcoma
Development of nonsymmetrical 1,4-disubstituted anthraquinones that are potently active against cisplatin-resistant ovarian cancer cells.
Osteosarcoma
Effect of the traditional Chinese medicine Qi Teng Xiao Zhuo granules on chronic glomerulonephritis rats studied by using long noncoding RNAs expression profiling.
Osteosarcoma
Flow-based cytometric analysis of cell cycle via simulated cell populations.
Osteosarcoma
Long non?coding RNA?DUXAP8 regulates TOP2A in the growth and metastasis of osteosarcoma via microRNA?635.
Osteosarcoma
microRNA-338-3p inhibits proliferation, migration, invasion, and EMT in osteosarcoma cells by targeting activator of 90 kDa heat shock protein ATPase homolog 1.
Osteosarcoma
Non-SMC Element 2 (NSMCE2) of the SMC5/6 Complex Helps to Resolve Topological Stress.
Osteosarcoma
Role of Topoisomerases in Pediatric High Grade Osteosarcomas: TOP2A Gene Is One of the Unique Molecular Biomarkers of Chemoresponse.
Osteosarcoma
Secondary thyroid papillary carcinoma in osteosarcoma patients: report of two cases.
Osteosarcoma
Selected using bioinformatics and molecular docking analyses, PHA-793887 is effective against osteosarcoma.
Osteosarcoma
The p53 tumor suppressor stimulates the catalytic activity of human topoisomerase IIalpha by enhancing the rate of ATP hydrolysis.
Osteosarcoma
Therapeutic effect of pirarubicin-based chemotherapy for osteosarcoma patients with lung metastasis.
Osteosarcoma
Topoisomerase II expression in osseous tissue.
Osteosarcoma
[Histogenesis of giant cell tumors of bone. comparative, ultrastructural and histo-enzymologic study of osteoforming tumors and malignant and giant cell tumors]
Otitis
[Gyrase inhibitor in the local treatment of the chronically infected middle ear following surgery]
Ototoxicity
Ototoxicity of gyrase antagonist ciprofloxacin?
Ovarian Cysts
Ecto-nucleotidases activities in the contents of ovarian endometriomas: potential biomarkers of endometriosis.
Ovarian Neoplasms
Activity of M3814, an Oral DNA-PK Inhibitor, In Combination with Topoisomerase II Inhibitors in Ovarian Cancer Models.
Ovarian Neoplasms
Altered expression of gamma-glutamylcysteine synthetase, metallothionein and topoisomerase I or II during acquisition of drug resistance to cisplatin in human ovarian cancer cells.
Ovarian Neoplasms
Altered Expression Pattern of Topoisomerase IIalpha in Ovarian Tumor Epithelial and Stromal Cells after Platinum-Based Chemotherapy.
Ovarian Neoplasms
Antibody immunity to the p53 oncogenic protein is a prognostic indicator in ovarian cancer.
Ovarian Neoplasms
ATAD2 predicts poor outcomes in patients with ovarian cancer and is a marker of proliferation.
Ovarian Neoplasms
Characterization of human soft-tissue sarcoma xenografts for use in secondary drug screening.
Ovarian Neoplasms
Contribution of c-erbB-2 and topoisomerase IIalpha to chemoresistance in ovarian cancer.
Ovarian Neoplasms
Curcumin induces apoptosis by inhibiting sarco/endoplasmic reticulum Ca(2+) ATPase activity in ovarian cancer cells.
Ovarian Neoplasms
Development of anthracenyl-amino acid conjugates as topoisomerase I and II inhibitors that circumvent drug resistance.
Ovarian Neoplasms
DNA topoisomerase IIalpha and -beta expression in human ovarian cancer.
Ovarian Neoplasms
Dual functions of the homeoprotein DLX4 in modulating responsiveness of tumor cells to topoisomerase II-targeting drugs.
Ovarian Neoplasms
EBNA1 may prolong G(2)/M phase and sensitize HER2/neu-overexpressing ovarian cancer cells to both topoisomerase II-targeting and paclitaxel drugs.
Ovarian Neoplasms
Endogenous tumor necrosis factor enhances topoisomerase II inhibitors activity in human ovarian cancer cell lines.
Ovarian Neoplasms
Estrogen-regulated gene expression predicts response to endocrine therapy in patients with ovarian cancer.
Ovarian Neoplasms
F14512, a polyamine-vectorized inhibitor of topoisomerase II, exhibits a marked anti-tumor activity in ovarian cancer.
Ovarian Neoplasms
Human DNA topoisomerase II-alpha.
Ovarian Neoplasms
Immunohistochemical and two-parameter flow cytometric studies of DNA topoisomerase II alpha in human epithelial ovarian carcinoma and germ cell tumor.
Ovarian Neoplasms
Improvement of sensitivity to platinum compound with siRNA knockdown of upregulated genes in platinum complex-resistant ovarian cancer cells in vitro.
Ovarian Neoplasms
Integrative analysis of key candidate genes and signaling pathways in ovarian cancer by bioinformatics.
Ovarian Neoplasms
Millepachine, a potential topoisomerase II inhibitor induces apoptosis via activation of NF-?B pathway in ovarian cancer.
Ovarian Neoplasms
MiR-200b-5p inhibits proliferation of ovarian cancer cells by targeting ATAD2 and regulating PI3K/AKT signaling pathway.
Ovarian Neoplasms
Molecular analysis of the topoisomerase II alpha gene and its expression in human ovarian cancer.
Ovarian Neoplasms
Multiple drug resistance parameter expression in ovarian cancer.
Ovarian Neoplasms
Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line.
Ovarian Neoplasms
Paclitaxel inhibits expression of heat shock protein 27 in ovarian and uterine cancer cells.
Ovarian Neoplasms
Phase I dose-escalation study of F14512, a polyamine-vectorized topoisomerase II inhibitor, in patients with platinum-refractory or resistant ovarian cancer.
Ovarian Neoplasms
Potentiation of TNF-mediated cell killing by mitoxantrone. Relationship to DNA single-strand break formation.
Ovarian Neoplasms
Potentiation of topoisomerase I and II inhibitors cell killing by tumor necrosis factor: relationship to DNA strand breakage formation.
Ovarian Neoplasms
Potentiation of tumour necrosis factor-mediated cell killing by VP16 on human ovarian cancer cell lines. In vitro results and clinical implications.
Ovarian Neoplasms
Prognostic impact of KI67, p53, human epithelial growth factor receptor 2, topoisomerase IIalpha, epidermal growth factor receptor, and nm23 expression of ovarian carcinomas and disseminated tumor cells in the bone marrow.
Ovarian Neoplasms
Prognostic role of topoisomerase-IIalpha in advanced ovarian cancer patients.
Ovarian Neoplasms
Proliferation and invasion of colon cancer cells are suppressed by knockdown of TOP2A.
Ovarian Neoplasms
RHPN1?AS1 promotes ovarian carcinogenesis by sponging miR?6884?5p thus releasing TOP2A mRNA.
Ovarian Neoplasms
Sister-chromatid exchanges, chromosomal aberrations and cytotoxicity produced by topoisomerase II-targeted drugs in sensitive (A2780) and resistant (A2780-DX3) human ovarian cancer cells: correlations with the formation of DNA double-strand breaks.
Ovarian Neoplasms
The potential mechanism of chemosensitive difference between 2 types of ovarian cancer.
Ovarian Neoplasms
TOP2A gene copy gain predicts response of epithelial ovarian cancers to pegylated liposomal doxorubicin: TOP2A as marker of response to PLD in ovarian cancer.
Ovarian Neoplasms
TOP2A Promotes Tumorigenesis of High-grade Serous Ovarian Cancer by Regulating the TGF-?/Smad Pathway.
Ovarian Neoplasms
Topoisomerase II immunostaining as a prognostic marker for survival in ovarian cancer.
Ovarian Neoplasms
Tumor- and stromal cell-specific expression of topoisomerase II? and HER-2/neu in primary and recurrent ovarian cancer: Results of a prospective study.
Ovarian Neoplasms
[Expression of c-erbB-2 and topoisomerase II alpha in relation to chemoresistance in ovarian cancer]
Overweight
Peculiarities of the effects of bile acids on atpase activity of the colon mucosa in patients with overweight and irritable bowel syndrome.
Pancreatic Neoplasms
A subset of pancreatic adenocarcinomas demonstrates coamplification of topoisomerase IIalpha and HER2/neu: use of immunolabeling and multicolor FISH for potential patient screening andtreatment.
Pancreatic Neoplasms
Acridine-based agents with topoisomerase II activity inhibit pancreatic cancer cell proliferation and induce apoptosis.
Pancreatic Neoplasms
Dual Inhibition of Topoisomerase II and Tyrosine Kinases by the Novel Bis-Fluoroquinolone Chalcone-Like Derivative HMNE3 in Human Pancreatic Cancer Cells.
Pancreatic Neoplasms
Ectopic expression of the microtubule-dependent motor protein Eg5 promotes pancreatic tumourigenesis.
Pancreatic Neoplasms
Effects of bafilomycin A1, a vacuolar type H+ ATPase inhibitor, on the thermosensitivity of a human pancreatic cancer cell line.
Pancreatic Neoplasms
Gene expression profiling identifies novel key players involved in the cytotoxic effect of Artesunate on pancreatic cancer cells.
Pancreatic Neoplasms
Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer.
Pancreatic Neoplasms
Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-independent pancreatic cancer cell death.
Pancreatic Neoplasms
Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray.
Pancreatic Neoplasms
Nanoparticle-based hyperthermia distinctly impacts production of ROS, expression of Ki-67, TOP2A, and TPX2, and induction of apoptosis in pancreatic cancer.
Pancreatic Neoplasms
Network-based integration of mRNA and miRNA profiles reveals new target genes involved in pancreatic cancer.
Pancreatic Neoplasms
On the role of topoisomerase I in mediating the cytotoxicity of 9-aminoacridine-based anticancer agents.
Pancreatic Neoplasms
The growth inhibitory effect of gambogic acid on pancreatic cancer cells.
Pancreatic Neoplasms
TOP2A induces malignant character of pancreatic cancer through activating ?-catenin signaling pathway.
Pancreatic Neoplasms
Topoisomerase expression and amplification in solid tumours: Analysis of 24,262 patients.
Pancreatic Neoplasms
Up-regulation of telomerase activity in human pancreatic cancer cells after exposure to etoposide.
Pancreatitis
Allograft steatohepatitis in progressive familial intrahepatic cholestasis type 1 after living donor liver transplantation.
Pancreatitis
Effect of Qingyitang on activity of intracellular Ca2+-Mg2+-ATPase in rats with acute pancreatitis.
Pancreatitis, Chronic
[Topoisomerase IIalpha and HER2/neu gene alterations and their correlation in pancreatic ductal adenocarcinomas]
Papilloma
The bovine papilloma virus E1 protein has ATPase activity essential to viral DNA replication and efficient transformation in cells.
Papilloma
[Multivariate analysis of the parameters related to recurrence of laryngeal papilloma in adult]
Papilloma, Inverted
[Expression and significance of Msx2 and topo II-alpha in sinonasal inverted papilloma].
Papillomavirus Infections
Human papillomavirus infection and expression of ATPase family AAA domain containing 3A, a novel anti-autophagy factor, in uterine cervical cancer.
Papillomavirus Infections
Subpopulations of Langerhans' cells in cervical neoplasia.
Paralysis
A metabolic link between the astrocytic ?2-Na/K ATPase and episodic paralysis.
Paralysis
Astrocyte deletion of ?2-Na/K ATPase triggers episodic motor paralysis in mice via a metabolic pathway.
Paralysis
Clotrimazole, an antimycotic drug, inhibits the sarcoplasmic reticulum calcium pump and contractile function in heart muscle.
Paralysis
Erythrocyte sodium-potassium pump in thyrotoxic periodic paralysis.
Paralysis
In vivo and in vitro sodium pump activity in subjects with thyrotoxic periodic paralysis.
Paralysis
Mechanism of thyrotoxic periodic paralysis.
Paralysis
Thyrotoxic periodic paralysis and polymorphisms of sodium-potassium ATPase genes.
Paraplegia
A pharmacogenetic study of docetaxel and thalidomide in patients with castration-resistant prostate cancer using the DMET genotyping platform.
Parasitic Diseases
Reprint of "The mechanism of negative DNA supercoiling: a cascade of DNA-induced conformational changes prepares gyrase for strand passage".
Parasitic Diseases
The mechanism of negative DNA supercoiling: A cascade of DNA-induced conformational changes prepares gyrase for strand passage.
Paratuberculosis
A critical role of interleukin-10 in the response of bovine macrophages to infection by Mycobacterium avium subsp paratuberculosis.
Paresthesia
Acral paresthesias in the Andes and neurology at sea level.
Paresthesia
Palytoxin Poisoning After Dermal Contact with Zoanthid Coral.
Parkinson Disease
A comprehensive genetic study of the proteasomal subunit S6 ATPase in German Parkinson's disease patients.
Parkinson Disease
A lipid switch unlocks Parkinson's disease-associated ATP13A2.
Parkinson Disease
Atp13a2 Deficiency Aggravates Astrocyte-Mediated Neuroinflammation via NLRP3 Inflammasome Activation.
Parkinson Disease
Digoxin : a model for hypothalamic regulation of neuronal transmission, endocrine function, immunity and cytodifferentiation.
Parkinson Disease
Genetic association study of the P-type ATPase ATP13A2 in late-onset Parkinson's disease.
Parkinson Disease
Impact of recent genetic findings in Parkinson's disease.
Parkinson Disease
Isoprenoid pathway and free radical generation and damage in neuropsychiatric disorders.
Parkinson Disease
Lysosomal dysfunction in Parkinson disease: ATP13A2 gets into the groove.
Parkinson Disease
Pharmacokinetics, Safety, and Tolerability of Orally Administered Ursodeoxycholic Acid in Patients With Parkinson's Disease-A Pilot Study.
Parkinson Disease
Protective and toxic roles of dopamine in Parkinson's disease.
Parkinson Disease
Reduced Cytosolic Calcium as an Early Decisive Cellular State in Parkinson's Disease and Synucleinopathies.
Parkinson Disease
The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein--implications for Parkinson's disease.
Parkinson Disease
Vacuolar protein sorting 4B regulates apoptosis of intestinal epithelial cells via p38 MAPK in Crohn's disease.
Parkinsonian Disorders
Abnormal high-frequency burst firing of cerebellar neurons in rapid-onset dystonia-parkinsonism.
Parkinsonian Disorders
Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration.
Parkinsonian Disorders
Generation of induced pluripotent stem cell line (ZZUi007-A) from a 52-year-old patient with a novel CHCHD2 gene mutation in Parkinson's disease.
Parkinsonian Disorders
Genetic analysis of the ATP1B4 gene in Chinese Han patients with Parkinson's disease.
Parkinsonian Disorders
Novel mutations affecting the Na, K ATPase alpha model complex neurological diseases and implicate the sodium pump in increased longevity.
Parkinsonian Disorders
Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression.
Parkinsonian Disorders
Sex differences in autophagy-mediated diseases: toward precision medicine.
Pemphigus, Benign Familial
A case of generalized Hailey-Hailey disease with fatal liver injury.
Pemphigus, Benign Familial
A family with atypical Hailey Hailey disease--is there more to the underlying genetics than ATP2C1?
Pemphigus, Benign Familial
Effect of Hailey-Hailey Disease mutations on the function of a new variant of human secretory pathway Ca2+/Mn2+-ATPase (hSPCA1).
Pemphigus, Benign Familial
Effects of drugs and anticytokine antibodies on expression of ATP2A2 and ATP2C1 in cultured normal human keratinocytes.
Pemphigus, Benign Familial
Hailey-Hailey disease and tight junctions: Claudins 1 and 4 are regulated by ATP2C1 gene encoding Ca(2+) /Mn(2+) ATPase SPCA1 in cultured keratinocytes.
Pemphigus, Benign Familial
Hailey-Hailey disease: molecular and clinical characterization of novel mutations in the ATP2C1 gene.
Pemphigus, Benign Familial
Lithium suppresses epidermal SERCA2 and PMR1 levels in the rat.
Pemphigus, Benign Familial
Structure/activity Relationship of Thapsigargin Inhibition on the Purified Golgi/secretory Pathway Ca2+/Mn2+ Transport ATPase (SPCA1a).
Peptic Ulcer
Cytotoxic isolates of Helicobacter pylori from peptic ulcer diseases decrease K+-dependent ATPase activity in HeLa cells.
Peptic Ulcer
Role of protective drugs in the prevention of ulcer relapse.
Peptic Ulcer
The biochemical and pharmacological properties of a newly synthesized H+-K+ ATPase inhibitor, 2-dimethylamino-4,5-dihydrothiazolo[4,5:3,4]pyridol-[1,2-a]benzimidazol e.
Peptic Ulcer
[Substituted benzimidazole, inhibiting substance of K+/H+ ATPase of parietal cells--a new principle in the treatment of peptic ulcer]
Peptic Ulcer
[Therapy of peptic ulcer. ATPase inhibitors]
Perinatal Death
Role of topoisomerase IIbeta in the expression of developmentally regulated genes.
Perinatal Death
Topoisomerase IIbeta is required for proper retinal development and survival of postmitotic cells.
Periodontitis
[The ATPase content of the blood neutrophils and lymphocytes in patients with chronic periodontitis]
Peripheral Nervous System Diseases
Endoneurial ATPase activity in Tangier disease and other peripheral neuropathies.
Peripheral Nervous System Diseases
New pathways for an old molecule: The role of the Na(+)-K(+) ATPase pump in peripheral neuropathy.
Peripheral Nervous System Diseases
Novel mutations in ATPase 8, ND1 and ND5 genes associated with peripheral neuropathy of diabetes.
Peritonitis
Alterations in the activities of DNA topoisomerase enzymes and O6-methylguanine-DNA-methyltransferase in septic rat liver.
Peritonitis
[Complicated umbilical hernia in patients with decompensated liver cirrhosis : Concept for risk reduction of repair.]
Perivascular Epithelioid Cell Neoplasms
Acute lymphoblastic leukemia secondary to chemoradiotherapy for perivascular epithelioid cell tumor of uterus.
Peroxisomal Disorders
Marked inhibition of Na+, K(+)- ATPase activity and the respiratory chain by phytanic acid in cerebellum from young rats: possible underlying mechanisms of cerebellar ataxia in Refsum disease.
Peroxisomal Disorders
Molecular snapshots of the Pex1/6 AAA+ complex in action.
Persistent Infection
Topoisomerase IIa protein expression analysis in oral squamous cell carcinoma.
Phenylketonurias
Effects of phenylalanine and its deaminated metabolites on Na+,K+-ATPase activity in synaptosomes from rat brain.
Pheochromocytoma
Blockade of plasma membrane calcium pumping ATPase isoform I impairs nerve growth factor-induced neurite extension in pheochromocytoma cells.
Pheochromocytoma
Copper efflux from murine microvascular cells requires expression of the menkes disease Cu-ATPase.
Pheochromocytoma
Nerve growth factor and epidermal growth factor rescue PC12 cells from programmed cell death induced by etoposide: distinct modes of protection against cell death by growth factors and a protein-synthesis inhibitor.
Pheochromocytoma
Prevention of oxidative injury by flavonoids from stems and leaves of Scutellaria baicalensis Georgi in PC12 cells.
phosphatidylinositol 3-kinase deficiency
Active vacuolar H+ ATPase and functional cycle of Rab5 are required for the vacuolation defect triggered by PtdIns(3,5)P2 loss under PIKfyve or Vps34 deficiency.
Photosensitivity Disorders
Inhibition of the ATPase activity of P-glycoprotein by porphyrin photosensitization of multidrug-resistant cells in vitro.
Photosensitivity Disorders
Photosensitization of mitochondrial adenosine-triphosphatase and adenylate kinase by hematoporphyrin derivative in vitro.
Phyllodes Tumor
Predictors of phyllodes tumours on core biopsy specimens of fibroepithelial neoplasms.
Pituitary Neoplasms
Cyclins D1 and D3 and topoisomerase II alpha in inactive pituitary adenomas.
Pituitary Neoplasms
Expression of cell proliferation markers in pituitary adenomas--correlation and clinical relevance of MIB-1 and anti-topoisomerase-IIalpha.
Pituitary Neoplasms
Identification of the potential therapeutic target gene UBE2C in human hepatocellular carcinoma: An investigation based on GEO and TCGA databases.
Pituitary Neoplasms
Topoisomerase IIalpha expression in pituitary adenomas and carcinomas: relationship to tumor behavior.
Plague
A Yersinia pestis YscN ATPase mutant functions as a live attenuated vaccine against bubonic plague in mice.
Plasmacytoma
[The importance of the ATPase reaction in the diagnosis of plasmacytoma]
Plasmacytoma
[The role of distinct membrane components of the enzyme in the ouabain sensitivity of Na+/K+ ATPase]
Pneumococcal Infections
Nonoptimal DNA topoisomerases allow maintenance of supercoiling levels and improve fitness of Streptococcus pneumoniae.
Pneumocystis Infections
Alteration in expression of the rat mitochondrial ATPase 6 gene during Pneumocystis carinii infection.
Pneumonia
NTPDase1/CD39 and aberrant purinergic signalling in the pathogenesis of COPD.
Pneumonia
The frequency of DNA gyrase and topoisomerase IV mutations, and plasmid-mediated quinolone resistance genes among Escherichia coli and Klebsiella pneumoniae isolated from urinary tract infections in Azerbaijan, Iran.
Poliomyelitis
Fatigue of chronically overused motor units in prior polio patients.
Polycystic Kidney Diseases
Cellular and molecular mechanisms of renal development and tubulogenesis.
Polycystic Kidney Diseases
In vitro modulation of tubular cyst regression in murine polycystic kidney disease.
Polycystic Kidney Diseases
Na-K ATPase activity in murine glucocorticoid induced polycystic kidney disease in vivo.
Polycythemia Vera
Decreased (Ca2+ + Mg2+)-stimulated ATPase activity in erythrocyte membranes from polycythemia vera patients.
Polyneuropathies
Association of diabetic neuropathy with Na/K ATPase gene polymorphism.
Polyuria
The pathophysiology of septic shock: acute renal failure in rats following live E coli injection. A histochemical study of the proximal tubules.
Potassium Deficiency
Effects of low-potassium diet on N-ethylmaleimide-sensitive ATPase in the distal nephron segments.
Potassium Deficiency
Proceedings: Influence of potassium deficiency and chronic treatment with digitoxin on the activity of the (Na+ plus K+)-activated ATPase and digitoxin toxicity.
Poxviridae Infections
Comparative sequence analysis of poxvirus A32 gene encoded ATPase protein and carboxyl terminal heterogeneity of Indian orf viruses.
Pre-Eclampsia
Circulating bufodienolide and cardenolide sodium pump inhibitors in preeclampsia.
Pre-Eclampsia
Digoxin Immune Fab Protects Endothelial Cells from Ouabain-Induced Barrier Injury.
Pre-Eclampsia
Impaired recovery of intracellular calcium and force after activation in isolated myometrial and subcutaneous resistance arteries from women with preeclampsia.
Pre-Eclampsia
Involvement of marinobufagenin in a rat model of human preeclampsia.
Pre-Eclampsia
Marinobufagenin impairs first trimester cytotrophoblast differentiation.
Pre-Eclampsia
Na/K- and Mg-ATPase activity in the placenta and in maternal and cord erythrocytes of pre-eclamptic patients.
Pre-Eclampsia
Preeclampsia and Na,K-ATPase activity of red blood cell ghosts from neonatal and maternal blood.
Pre-Eclampsia
Resibufogenin corrects hypertension in a rat model of human preeclampsia.
Pre-Eclampsia
Role of endogenous digitalis-like factors in the clinical manifestations of severe preeclampsia: a sytematic review.
Pre-Eclampsia
[Histological, morphometric and topochemical analysis of placentas from pregnancies with EPH Gestosis (author's transl)]
Pre-Eclampsia
[Microarray analysis of differentially expressed genes in peripheral leucocytes derived from severe preeclampsia and normotensive pregnancies]
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Acute lymphoid leukemia with t(4;11) (q21;q23) following chemotherapy with cytostatic agents targeting at DNA-topoisomerase II.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
An in vivo topoisomerase II cleavage site and a DNase I hypersensitive site colocalize near exon 9 in the MLL breakpoint cluster region.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
ATP Binding Cassette C1 (ABCC1/MRP1)-mediated drug efflux contributes to disease progression in T-lineage acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Concurrent translocations of MLL and CBFA2 (AML1) genes with new partner breakpoints in a child with secondary myelodysplastic syndrome after treatment of acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Determination of DNA topoisomerase II in newly diagnosed childhood acute lymphoblastic leukemia by immunocytochemistry and RT-PCR.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
DNA topoisomerase: the mechanism of resistance to DNA topoisomerase II inhibitor VP-16.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Drug resistance to DNA topoisomerase I and II inhibitors in human leukemia, lymphoma, and multiple myeloma.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Drug-induced changes in the expression of MDR-associated genes: investigations on cultured cell lines and chemotherapeutically treated leukemias.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Etoposide in the treatment of leukemias.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Immunohistochemical study of DNA topoisomerase II in human gastric disorders.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Impact of Topoisomerase II alpha and spermine on the clinical outcome of children with acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Inversion of chromosome 11 inv(11)(p15q22), as a recurring chromosomal aberration associated with de novo and secondary myeloid malignancies: identification of a P1 clone spanning the 11q22 breakpoint.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Messenger RNA expression of resistance factors and their correlation to the proliferative activity in childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
MLL/AF-1p fusion in therapy-related early pre-B acute lymphoblastic leukemia with t(1;11)(p32;q23) translocation developing in the relapse phase of acute promyelocytic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Modification of topoisomerase genes copy number in newly diagnosed childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Multilocus association of genetic variants in MLL, CREBBP, EP300, and TOP2A with childhood acute lymphoblastic leukemia in Hispanics from Texas.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Relationship of DNA topoisomerase II alpha and beta expression to cytotoxicity of antineoplastic agents in human acute lymphoblastic leukemia cell lines.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Resistance of human leukemic and normal lymphocytes to drug-induced DNA cleavage and low levels of DNA topoisomerase II.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Single-strand conformational polymorphism analysis of the M(r) 170,000 isozyme of DNA topoisomerase II in human tumor cells.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Sulfonoquinovosyl diacylglyceride selectively targets acute lymphoblastic leukemia cells and exerts potent anti-leukemic effects in vivo.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Therapy-associated lymphoid proliferations.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Therapy-induced Deletion in 11q23 Leading to Fusion of KMT2A With ARHGEF12 and Development of B Lineage Acute Lymphoplastic Leukemia in a Child Treated for Acute Myeloid Leukemia Caused by t(9;11)(p21;q23)/KMT2A-MLLT3.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Therapy-related myeloid leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Topoisomerase II alpha gene expression in childhood acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Translocation t(4;11)(q21;q23) and MLL gene rearrangement in acute lymphoblastic leukemia secondary to anti topoisomerase II anticancer agents.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Nationwide survey of therapy-related leukemia in childhood in Japan.
Presbyopia
[Study of the Mechanisms of Maintaining the Transparency of the Lens and Treatment of Its Related Diseases for Making Anti-cataract and/or Anti-presbyopia Drugs].
Prion Diseases
Basic and clinical aspects of copper.
Progeria
The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells.
Prostatic Hyperplasia
Immunohistochemical expression of topoisomerase II alpha and Her-2/neu in prostatic carcinoma and benign prostatic hyperplasia.
Prostatic Hyperplasia
Low-level TOP2A amplification in prostate cancer is associated with HER2 duplication, androgen resistance, and decreased survival.
Prostatic Intraepithelial Neoplasia
alpha-Methylacyl coenzyme A racemase, Ki-67, and topoisomerase IIalpha in cystoprostatectomies with incidental prostate cancer.
Prostatic Intraepithelial Neoplasia
Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements.
Prostatic Intraepithelial Neoplasia
Immunohistochemical staining for DNA topoisomerase II-alpha in benign, premalignant, and malignant lesions of the prostate.
Prostatic Neoplasms
A novel epoxypropoxy flavonoid derivative and topoisomerase II inhibitor, MHY336, induces apoptosis in prostate cancer cells.
Prostatic Neoplasms
Aberrant expression of SWI/SNF catalytic subunits BRG1/BRM is associated with tumor development and increased invasiveness in prostate cancers.
Prostatic Neoplasms
Activation of the tumor metastasis suppressor gene, KAI1, by etoposide is mediated by p53 and c-Jun genes.
Prostatic Neoplasms
alpha-Methylacyl coenzyme A racemase, Ki-67, and topoisomerase IIalpha in cystoprostatectomies with incidental prostate cancer.
Prostatic Neoplasms
Antiandrogens Inhibit ABCB1 Efflux and ATPase Activity and Reverse Docetaxel Resistance in Advanced Prostate Cancer.
Prostatic Neoplasms
ATPase family AAA domain containing 3A is an anti-apoptotic factor and a secretion regulator of PSA in prostate cancer.
Prostatic Neoplasms
BRG1 is a prognostic indicator and a potential therapeutic target for prostate cancer.
Prostatic Neoplasms
Catalytic inhibitors of DNA topoisomerase II suppress the androgen receptor signaling and prostate cancer progression.
Prostatic Neoplasms
Chromatin remodeling ATPase BRG1 and PTEN are synthetic lethal in prostate cancer.
Prostatic Neoplasms
Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2.
Prostatic Neoplasms
Ethonafide-induced cytotoxicity is mediated by topoisomerase II inhibition in prostate cancer cells.
Prostatic Neoplasms
Etoposide and topoisomerase II inhibition for aggressive prostate cancer: Data from a translational study.
Prostatic Neoplasms
Etoposide induces growth arrest and disrupts androgen receptor signaling in prostate cancer cells.
Prostatic Neoplasms
Etoposide sensitivity of human prostatic cancer cell lines PC-3, DU 145 and LNCaP.
Prostatic Neoplasms
Expression of multidrug resistance related proteins and proliferative activity is increased in advanced clinical prostate cancer.
Prostatic Neoplasms
Expression of the non-gastric H+/K+ ATPase ATP12A in normal and pathological human prostate tissue.
Prostatic Neoplasms
Gene expression changes are age-dependent and lobe-specific in the brown Norway rat model of prostatic hyperplasia.
Prostatic Neoplasms
Heteronemin, a Marine Sesterterpenoid-Type Metabolite, Induces Apoptosis in Prostate LNcap Cells via Oxidative and ER Stress Combined with the Inhibition of Topoisomerase II and Hsp90.
Prostatic Neoplasms
Identification of core genes associated with prostate cancer progression and outcome via bioinformatics analysis in multiple databases.
Prostatic Neoplasms
Identification of UBE2C as hub gene in driving prostate cancer by integrated bioinformatics analysis.
Prostatic Neoplasms
In vitro sequence-dependent synergistic effect of suramin and camptothecin.
Prostatic Neoplasms
Induction of DNA damage and ATF3 by retigeric acid B, a novel topoisomerase II inhibitor, promotes apoptosis in prostate cancer cells.
Prostatic Neoplasms
Kinesin family member 18B regulates the proliferation and invasion of human prostate cancer cells.
Prostatic Neoplasms
Low-level TOP2A amplification in prostate cancer is associated with HER2 duplication, androgen resistance, and decreased survival.
Prostatic Neoplasms
Mitoxantrone-related acute myeloblastic leukaemia in a patient with metastatic hormone-refractory prostate cancer.
Prostatic Neoplasms
Novel combination therapy against metastatic and androgen-independent prostate cancer by using gefitinib, tamoxifen and etoposide.
Prostatic Neoplasms
One-pot synthesis of podophyllotoxin-thiourea congeners by employing NH?SO?H/NaI: Anticancer activity, DNA topoisomerase-II inhibition, and apoptosis inducing agents.
Prostatic Neoplasms
Phosphodiesterase Type 5 (PDE5) Inhibitors Sensitize Topoisomerase II Inhibitors in Killing Prostate Cancer Through PDE5-Independent Impairment of HR and NHEJ DNA Repair Systems.
Prostatic Neoplasms
Phosphorylation of Fas-associated death domain contributes to enhancement of etoposide-induced apoptosis in prostate cancer cells.
Prostatic Neoplasms
Pixelated spatial gene expression analysis from tissue.
Prostatic Neoplasms
Prognostication of prostate cancer based on TOP2A protein and gene assessment: TOP2A in prostate cancer.
Prostatic Neoplasms
Proliferation and invasion of colon cancer cells are suppressed by knockdown of TOP2A.
Prostatic Neoplasms
Prostate-specific antigen promoter driven gene therapy targeting DNA polymerase-alpha and topoisomerase II alpha in prostate cancer.
Prostatic Neoplasms
Regulation of apoptosis by androgens in prostate cancer cells.
Prostatic Neoplasms
Relation of ETS transcription factor family member ERG, androgen receptor and topoisomerase 2? expression to TMPRSS2-ERG fusion status in prostate cancer.
Prostatic Neoplasms
Silencing of PSMC2 inhibits development and metastasis of prostate cancer through regulating proliferation, apoptosis and migration.
Prostatic Neoplasms
The ability of biomarkers to predict systemic progression in men with high-risk prostate cancer treated surgically is dependent on ERG status.
Prostatic Neoplasms
The role of calcium, pH, and cell proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer cells induced by thapsigargin.
Prostatic Neoplasms
The structure and function of NKAIN2-a candidate tumor suppressor.
Prostatic Neoplasms
The structure of the nucleus in normal and neoplastic prostate cells: untangling the role of type 2 DNA topoisomerases.
Prostatic Neoplasms
The SWI/SNF ATPase Brm is a gatekeeper of proliferative control in prostate cancer.
Prostatic Neoplasms
TOP2A and EZH2 provide early detection of an aggressive prostate cancer subgroup.
Prostatic Neoplasms
Top2a identifies and provides epigenetic rationale for novel combination therapeutic strategies for aggressive prostate cancer.
Prostatic Neoplasms
TOP2Ahigh is the phenotype of recurrence and metastasis whereas TOP2Aneg cells represent cancer stem cells in prostate cancer.
Prostatic Neoplasms
Topoisomerase 2 Alpha Cooperates with Androgen Receptor to Contribute to Prostate Cancer Progression.
Prostatic Neoplasms
Transcription-induced DNA double strand breaks: both an oncogenic force and potential therapeutic target?
Prostatic Neoplasms
VCP relocalization limits mitochondrial activity, GSH depletion and ferroptosis during starvation in PC3 prostate cancer cells.
Prostatic Neoplasms
WRC-213, an l-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers.
Protein Deficiency
[Effect of dietary protein deficiency on Na and K content and ATPase activity of thymic, splenic, lymphatic, and blood lymphocytes in the rat]
Protein Deficiency
[Effect of protein deficiency on the nucleotide content and ATPase activity in rat tissues]
Protein Deficiency
[Mechanisms of pandrug-resistance of Pseudomonas aeruginosa]
Proteinuria
Decreased ATPase activity in adriamycin nephrosis is independent of proteinuria.
Proteinuria
Mitochondrial DNA deletion of proximal tubules is the result of itai-itai disease.
Proteinuria
Resibufogenin Prevents the Manifestations of Preeclampsia in an Animal Model of the Syndrome.
Pseudohypoaldosteronism
Erythrocyte transmembrane Na and K fluxes in pseudohypoaldosteronism.
Pseudomonas Infections
[Local treatment of Pseudomonas aeruginosa infection of the external ear canal with the gyrase inhibitor Tarivid]
Psoriasis
Langerhans' cells in patients with psoriasis: effect of treatment with PUVA, PUVA bath, etretinate and anthralin.
Psoriasis
Transmembrane cation fluxes and fatty acid composition of erythrocytes in psoriatic patients.
Psoriasis
[Level of oxidative phosphorylation, ATP content, and ATPase activity in the skin at various stages of psoriasis]
Pulmonary Disease, Chronic Obstructive
COPD ELICITS REMODELING OF THE DIAPHRAGM AND VASTUS LATERALIS MUSCLES IN HUMANS.
Pulmonary Disease, Chronic Obstructive
Effect of chronic obstructive pulmonary disease on calcium pump ATPase expression in human diaphragm.
Pulmonary Disease, Chronic Obstructive
Is the purinergic pathway involved in the pathology of COPD? Decreased lung CD39 expression at initial stages of COPD.
Pulmonary Disease, Chronic Obstructive
NTPDase1/CD39 and aberrant purinergic signalling in the pathogenesis of COPD.
Pulmonary Disease, Chronic Obstructive
Oxidative stress and damage to erythrocytes in patients with chronic obstructive pulmonary disease--changes in ATPase and acetylcholinesterase activity.
Pulmonary Disease, Chronic Obstructive
Physiological properties of human diaphragm muscle fibres and the effect of chronic obstructive pulmonary disease.
Pulmonary Edema
Role of endogenous digitalis-like factors in the clinical manifestations of severe preeclampsia: a sytematic review.
Pulmonary Valve Stenosis
Alterations of subunit composition and ATPase activity of myosin in early hypertrophied right ventricles of dogs with mild experimental pulmonic stenosis.
Pulmonary Valve Stenosis
Differential responses of canine myosin ATPase activity and tissue gases in the pressure-overloaded ventricle dependent upon degree of obstruction: mild versus severe pulmonic and aortic stenosis.
Pyelonephritis
[Lipid peroxidation and Ca-dependent ATPase activity in the microsomal fraction of renal tissue in patients with nephrolithiasis and chronic pyelonephritis]
Pyelonephritis
[Mycoplasma hominis. A rare causative agent of acute pyelonephritis]
Pyelonephritis
[Results of ofloxacin treatment of experimental urinary tract infections]
Pyelonephritis
[The suppression of the Ca ATpase activity of rat kidney microsomes under the action of blood plasma as an index of the severity of the status of pyelonephritis patients]
pyruvate kinase deficiency
Enzymatic pattern of glucose metabolic pathways in pyruvate kinase-deficient erythrocytes.
Rabies
The ATPase ATP6V1A facilitates rabies virus replication by promoting virion uncoating and interacting with the viral matrix protein.
Rectal Neoplasms
Human epidermal growth factor receptor-2 and topoisomerase II alpha expressions in rectal cancer.
Rectal Neoplasms
Pretreatment MR-Based Radiomics Signature as Potential Imaging Biomarker for Assessing the Expression of Topoisomerase II alpha (TOPO-II?) in Rectal Cancer.
Refsum Disease
Marked inhibition of Na+, K(+)- ATPase activity and the respiratory chain by phytanic acid in cerebellum from young rats: possible underlying mechanisms of cerebellar ataxia in Refsum disease.
Relative Energy Deficiency in Sport
Enzyme and immunohistochemical assessment of myocardial damage after ischaemia and reperfusion in a closed-chest pig model.
Renal Insufficiency
Biochemical abnormalities of platelets in renal failure. Evidence for decreased platelet serotonin, adenosine diphosphate and Mg-dependent adenosine triphosphatase.
Renal Insufficiency
Effect of dialysis on circulating Na,K ATPase inhibitor in uremic patients.
Renal Insufficiency
Effects of methylguanidine on sodium and organic ion transport.
Renal Insufficiency
Inhibition of Na+,K+-stimulated ATPase in the cochlea of the guinea pig. A potential cause of disturbed inner ear function in terminal renal failure.
Renal Insufficiency
Metabolism of gyrase inhibitors.
Renal Insufficiency
Natriuretic hormone activity in the urine of cirrhotic patients.
Renal Insufficiency
Pathophysiology of acute renal failure following living Escherichia coli injection in rats: high-energy metabolism and renal functions.
Renal Insufficiency
[Clinical studies on assay for Na-K ATPase in human blood cells. I. Erythrocyte Na-K ATPase assay in patients with thyroid dysfunction and in those with chronic renal failure]
Renal Insufficiency
[The endocochlear potential in experimental renal insufficiency]
Renal Insufficiency, Chronic
Ca2+-Mg2+-dependent ATP-ase activity and calcium homeostasis in children with chronic kidney disease.
Renal Insufficiency, Chronic
Erythrocyte membrane ATPase in patients with acute or chronic renal disease.
Renal Insufficiency, Chronic
The endogenous modulators of Ca2+-Mg2+-dependent ATPase in children with chronic kidney disease (CKD).
Renal Insufficiency, Chronic
[Changes in the activity of Na+ K+ ATPase in erythrocytes and immunoreactive plasma digoxin-like substances in chronic renal insufficiency: their relation to blood pressure levels]
Renal Insufficiency, Chronic
[Effect of hemodialysis on erythrocyte acetylcholinesterase and adenosine triphosphatase activity in chronic renal insufficiency]
Renal Insufficiency, Chronic
[Na + -K + dependent ATPase in the erythrocytes of patients with acute and chronic renal insufficiency]
Reperfusion Injury
Effect of ischemic preconditioning on mitochondrial oxidative phosphorylation and high energy phosphates in rat hearts.
Reperfusion Injury
Effect of propofol on mitochondrial ATP content and ATPase activity in hippocampus of rats with cerebral ischemia-reperfusion injury.
Reperfusion Injury
Effect of sevoflurane on the ATPase activity of hippocampal neurons in a rat model of cerebral ischemia-reperfusion injury via the cAMP-PKA signaling pathway.
Reperfusion Injury
Effects of electroacupuncture of different intensities on energy metabolism of mitochondria of brain cells in rats with cerebral ischemia-reperfusion injury.
Reperfusion Injury
Impact of cardiac-specific expression of CD39 on myocardial infarct size in mice.
Reperfusion Injury
Inhibition of heart sarcolemmal Ca(2+)-pump activity by oxygen free radicals.
Reperfusion Injury
Is remote ischaemic preconditioning of benefit to patients undergoing cardiac surgery?
Reperfusion Injury
Low extracellular K(+) increases intracellular Ca(2+) oscillation and injury by activating the reverse mode Na(+)-Ca(2+) exchanger and inhibiting the Na(+), K(+) ATPase in rat cardiomyocytes.
Reperfusion Injury
Role of Mitochondrial Enzymes and Sarcoplasmic ATPase in Cardioprotection Mediated by Aqueous Extract of Desmodium gangeticum (L) DC Root on Ischemic Reperfusion Injury.
Reperfusion Injury
The effect of captopril on membrane bound enzymes in ischemia-reperfusion injury.
Reperfusion Injury
[Effect of cardiomyopeptidin for injection on energy metabolism in isolated hearts of young rats after ischemia-reperfusion injury]
Reperfusion Injury
[Effects of Shenfu injection on prostacyclin, thromboxane A2 and activities of ATPases in rats exposed to hepatic ischemia-reperfusion injury]
Reperfusion Injury
[Study on regulation of tanshinone II(A) on GFAP and ATPase and PDI of cerebral ischemia reperfusion injury in rats].
Respiratory Insufficiency
Congenital myopathy with mosaic fibers and interlacing sarcomeres: a new structural myopathy.
Respiratory Insufficiency
Palytoxin Poisoning After Dermal Contact with Zoanthid Coral.
Respiratory Tract Infections
[Gyrase inhibitor in pneumology. Ofloxacin--a new broad spectrum antibiotic in acute and chronic respiratory tract infections]
Retinal Degeneration
Neurochemical studies on the inherited retinal degeneration of the rat. 3. Hexokinase, phosphofructokinase and atpase in the developing retina.
Retinal Detachment
Digoxin cannot account for the reported association of EKG abnormalities and rhegmatogenous retinal detachment.
Retinitis
A calcium signaling defect in the pathogenesis of a mitochondrial DNA inherited oxidative phosphorylation deficiency.
Retinitis
Diseases resulting from mitochondrial DNA point mutations.
Retinitis
Heterogeneous clinical presentation of the mtDNA NARP/T8993G mutation.
Retinitis
NARP Syndrome: A 20-Year Follow-Up.
Retinitis Pigmentosa
Catalytic activities of mitochondrial ATP synthase in patients with mitochondrial DNA T8993G mutation in the ATPase 6 gene encoding subunit a.
Retinitis Pigmentosa
Heterogeneous clinical presentation of the mtDNA NARP/T8993G mutation.
Retinitis Pigmentosa
Heterogeneous patterns of tissue injury in NARP syndrome.
Retinitis Pigmentosa
Mitochondrial DNA background modifies the bioenergetics of NARP/MILS ATP6 mutant cells.
Retinitis Pigmentosa
Neuroprotective effects of VCP modulators in mouse models of glaucoma.
Retinitis Pigmentosa
Rescue of a deficiency in ATP synthesis by transfer of MTATP6, a mitochondrial DNA-encoded gene, to the nucleus.
Retinitis Pigmentosa
Retinitis Pigmentosa Mutations in Bad Response to Refrigeration 2 (Brr2) Impair ATPase and Helicase Activity.
Retinitis Pigmentosa
Synthesis and preliminary biological evaluations of ionic and nonionic amphiphilic alpha-phenyl-N-tert-butylnitrone derivatives.
Retinitis Pigmentosa
The 8993 mtDNA mutation: heteroplasmy and clinical presentation in three families.
Retinitis Pigmentosa
The aleu207-->arg mutation in F1F0-ATP synthase from Escherichia coli. A model for human mitochondrial disease.
Retinitis Pigmentosa
The neurogenic weakness, ataxia and retinitis pigmentosa (NARP) syndrome mtDNA mutation (T8993G) triggers muscle ATPase deficiency and hypocitrullinaemia.
Retinitis Pigmentosa
The study of the pathogenic mechanism of mitochondrial diseases provides information on basic bioenergetics.
Retinoblastoma
Alterations in the proliferating compartment of gastric mucosa during Helicobacter pylori infection: the putative role of epithelial cells expressing p27(kip1).
Retinoblastoma
Apoptosis and cell cycle-related genes and proteins in classical Hodgkin lymphoma: application of tissue microarray technique.
Retinoblastoma
BRCA1-Mediated Ubiquitination Inhibits Topoisomerase IIalpha Activity in Response to Oxidative Stress.
Retinoblastoma
Coevolution of persistently infecting small DNA viruses and their hosts linked to host-interactive regulatory domains.
Retinoblastoma
Cytotoxic signalling by inhibitors of DNA topoisomerase II.
Retinoblastoma
Functional interaction between human topoisomerase IIalpha and retinoblastoma protein.
Retinoblastoma
High topoisomerase IIalpha expression associates with high proliferation rate and and poor prognosis in oligodendrogliomas.
Retinoblastoma
HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha.
Retinoblastoma
Inhibition of topoisomerase IIalpha expression by transforming growth factor-beta1 is abrogated by the papillomavirus E7 protein.
Retinoblastoma
Ionizing radiation and teniposide increase p21(waf1/cip1) and promote Rb dephosphorylation but fail to suppress E2F activity in MCF-7 breast tumor cells.
Retinoblastoma
Isolation of cDNAs encoding chicken homologues of the yeast SNF2 and Drosophila Brahma proteins.
Retinoblastoma
Mammalian Chromatin Remodeling Complex SWI/SNF Is Essential for Enhanced Expression of the Albumin Gene during Liver Development.
Retinoblastoma
Mapping the transcriptional transactivation function of simian virus 40 large T antigen.
Retinoblastoma
Nodular lesions of monocytic component in myelodysplastic syndrome.
Retinoblastoma
Secondary acute myeloid leukemia in a child treated for retinoblastoma: A case report with review of literature.
Retinoblastoma
Subependymal giant cell astrocytoma: a clinicopathological study of 23 cases with special emphasis on proliferative markers and expression of p53 and retinoblastoma gene proteins.
Retinoblastoma
The retinoblastoma gene and its product are targeted by ICBP90: a key mechanism in the G1/S transition during the cell cycle.
Retinoblastoma
Therapeutic Targeting of Nuclear Export Inhibition in Lung Cancer.
Retinoblastoma
Value of topoisomerase II alpha, MIB-1, p53, E-cadherin, retinoblastoma gene protein product, and HER-2/neu immunohistochemical expression for the prediction of biologic behavior in adrenocortical neoplasms.
Reye Syndrome
Reye syndrome: serum-induced alterations in brain mitochondrial function are blocked by fatty-acid-free albumin.
Rhabdomyolysis
Calcium sensitivity of force production and myofibrillar ATPase activity in muscles from Thoroughbreds with recurrent exertional rhabdomyolysis.
Rhabdomyolysis
Coding sequences of sarcoplasmic reticulum calcium ATPase regulatory peptides and expression of calcium regulatory genes in recurrent exertional rhabdomyolysis.
Rhabdomyosarcoma
DNA topoisomerase II immunostaining in human leukemia and rhabdomyosarcoma cell lines and their responses to topoisomerase II inhibitors.
Rhabdomyosarcoma
Drug-induced DNA hypermethylation and drug resistance in human tumors.
Rhabdomyosarcoma
E-cadherin, b-catenin and topoisomerase II expression in rhabdomyosarcomas.
Rhabdomyosarcoma
Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan.
Rhabdomyosarcoma
Functional interaction between human topoisomerase IIalpha and retinoblastoma protein.
Rhabdomyosarcoma
Sequestration of AS-DACA into Acidic Compartments of the Membrane Trafficking System as a Mechanism of Drug Resistance in Rhabdomyosarcoma.
Rhabdomyosarcoma
Simvastatin-induced compartmentalisation of doxorubicin sharpens up nuclear topoisomerase II inhibition in human rhabdomyosarcoma cells.
Rhabdomyosarcoma
Store-operated Ca(2+) entry in rhabdomyosarcoma cells.
Rhinitis, Allergic
Inhibition of the sodium, potassium adenosine triphosphatase enzyme in peripheral blood mononuclear cells of subjects with allergic rhinitis.
Rickets
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Rickets
Renal sodium transport in vitamin D resistant hypophosphatemic rickets.
RNA Virus Infections
Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6.
RNA Virus Infections
Novel catalytic activity associated with positive-strand RNA virus infection: nucleic acid-stimulated ATPase activity of the plum pox potyvirus helicaselike protein.
Rubella
Rubella vaccine-induced cellular immunity: evidence of associations with polymorphisms in the Toll-like, vitamin A and D receptors, and innate immune response genes.
Salmonella Infections
Salmonella enterica serovar Typhimurium mutants completely lacking the F(0)F(1) ATPase are novel live attenuated vaccine strains.
Sarcoidosis
Autoantibodies to DNA topoisomerase II in cryptogenic fibrosing alveolitis and connective tissue disease.
Sarcoidosis
Mutational analysis of human NOD1 and NOD2 NACHT domains reveals different modes of activation.
Sarcoma
A phase I trial of panobinostat and epirubicin in solid tumors with a dose expansion in patients with sarcoma.
Sarcoma
Acute lymphoblastic leukemia secondary to chemoradiotherapy for perivascular epithelioid cell tumor of uterus.
Sarcoma
Additive effect of adenovirus-mediated E2F-1 gene transfer and topoisomerase II inhibitors on apoptosis in human osteosarcoma cells.
Sarcoma
Antagonism in effectiveness of evofosfamide and doxorubicin through intermolecular electron transfer.
Sarcoma
Drug resistance in the treatment of sarcomas.
Sarcoma
Expression of drug resistance related proteins in sarcomas of the pulmonary artery and poorly differentiated leiomyosarcomas of other origin.
Sarcoma
Expression of E-cadherin, beta-catenin and topoisomerase IIalpha in leiomyosarcomas.
Sarcoma
Inhibition of AKT-Signaling Sensitizes Soft Tissue Sarcomas (STS) and Gastrointestinal Stromal Tumors (GIST) to Doxorubicin via Targeting of Homology-Mediated DNA Repair.
Sarcoma
Pan-Cancer Analysis of Alternative Lengthening of Telomere Activity.
Sarcoma
Prognostic value of proliferation in pleomorphic soft tissue sarcomas: a new look at an old measure.
Sarcoma
Prognostication of Soft Tissue Sarcomas Based on Chromosome 17q Gene and Protein Status: Evaluation of TOP2A, HER-2/neu, and Survivin.
Sarcoma
Sensitivity to TOP2 Targeting Chemotherapeutics Is Regulated by Oct1 and FILIP1L.
Sarcoma
The multifunctional protein fused in sarcoma (FUS) is a coactivator of microphthalmia-associated transcription factor (MITF).
Sarcoma 180
Effect of immunoglobulin G on membrane-bound enzyme activity of sarcoma 180 cells.
Sarcoma, Ewing
E1A sensitizes HER2/neu-overexpressing Ewing's sarcoma cells to topoisomerase II-targeting anticancer drugs.
Sarcoma, Ewing
E1A specifically enhances sensitivity to topoisomerase IIalpha targeting anticancer drug by up-regulating the promoter activity.
Sarcoma, Ewing
Hematologic abnormalities and acute myeloid leukemia in children and adolescents administered intensified chemotherapy for the Ewing sarcoma family of tumors.
Sarcoma, Ewing
Preclinical Evaluation of Combined Topoisomerase and Proteasome Inhibition Against Pediatric Malignancies.
Sarcoma, Ewing
Secondary ALL after Successful Treatment of Ewing's Sarcoma: A Case Report.
Sarcoma, Kaposi
Reduced Langerhans' cell Ia antigen and ATPase activity in patients with the acquired immunodeficiency syndrome.
Sarcoma, Synovial
Nuclear expression of Y-box-binding protein-1 correlates with P-glycoprotein and topoisomerase II alpha expression, and with poor prognosis in synovial sarcoma.
Sarcoma, Synovial
Synovial sarcoma cell lines showed reduced DNA repair activity and sensitivity to a PARP inhibitor.
Sarcoma, Yoshida
Inactivation of membrane-bound (Na+ +K+)-ATPase of Yoshida sarcoma cells and cobra venom cytotoxin complex with the glycolipid components of the enzyme system.
Sarcoma, Yoshida
Increased content of natural ATPase inhibitor in tumor mitochondria.
Schistosomiasis mansoni
Effect of praziquantel treatment on brain and kidney ATPase activities in healthy and schistosoma mansoni-infected mice.
Scleroderma, Localized
Anti-DNA topoisomerase IIalpha autoantibodies in localized scleroderma.
Scleroderma, Systemic
Anti-DNA topoisomerase II alpha autoantibodies in Japanese patients with systemic sclerosis.
Scoliosis
Contractile protein studies on platelets from patients with idiopathic scoliosis.
Scoliosis
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Scrapie
Protein Quality Control under Oxidative Stress Conditions.
Seizures
Altered Na+-K+ ATPase immunoreactivity within GABAergic neurons in the gerbil hippocampal complex induced by spontaneous seizure and vigabatrin treatment.
Seizures
Brain cortex Na(+)-K+ ATPase activities in streptozotocin-diabetic and pentylenetetrazol-epileptic rats.
Seizures
Cerebral magnesium and sodium-potassium ATPase following audiogenic seizures in mice.
Seizures
Disruption of the ATP/adenosine balance in CD39(-/-) mice is associated with handling-induced seizures.
Seizures
Epilepsy and membrane Na+K+ATPase: changes in activity using an experimental model of epilepsy.
Seizures
Genetic study of cationic ATPase activities and audiogenic seizure susceptibility in recombinant inbred and congenic strains of mice.
Seizures
In vitro dose dependent inverse effect of nantenine on synaptosomal membrane K+-p-NPPase activity.
Seizures
Muscle and serum adenosine triphosphatase in patients suffering from tetanus.
Seizures
Na+K+ ATPase activity in the rat hippocampus: a study in the pilocarpine model of epilepsy.
Seizures
Neuropathology in Drosophila mutants with increased seizure susceptibility.
Seizures
No evidence of ATP1A2 involvement in 12 multiplex Italian families with benign familial infantile seizures.
Seizures
Predictors and mechanisms of epilepsy occurrence in cerebral gliomas: What to look for in clinicopathology.
Seizures
Relationship of serum ATPase activity and the levels of neuron- specific enolase, S100B and B-cell lymphoma/leukemia-2 with cognitive function after epileptic seizure.
Seizures
Seizure threshold, adrenalectomy and sodium-potassium stimulated ATPase in rat brain.
Seizures
Selective decrease of Na+/k+ -ATPase activity in the brain of hypothyroid rats.
Seizures
[ATPase activity in neurons and neuroglia during convulsions induced by picrotoxin]
Seminoma
A study of topoisomerase activity in human testicular cancers.
Seminoma
Expression of DNA toposiomerase I and DNA topoisomerase II-alpha in testicular seminomas.
Seminoma
Topoisomerase II alpha expression in testicular germ cell tumors.
Sepsis
Alterations in the activities of DNA topoisomerase enzymes and O6-methylguanine-DNA-methyltransferase in septic rat liver.
Sepsis
Alterations of Na+-K+-ATPase, Ca2+-ATPase, and Mg2+-ATPase activities in erythrocyte, muscle, and liver of traumatic and septic patients.
Sepsis
Altered phospholamban-calcium ATPase interaction in cardiac sarcoplasmic reticulum during the progression of sepsis.
Sepsis
Altered phosphorylation and calcium sensitivity of cardiac myofibrillar proteins during sepsis.
Sepsis
Candidate genes and pathogenesis investigation for sepsis-related acute respiratory distress syndrome based on gene expression profile.
Sepsis
Cardiac myofilament protein function is altered during sepsis.
Sepsis
Complement and sepsis-induced heart dysfunction.
Sepsis
Gene Network for Identifying the Entropy Changes of Different Modules in Pediatric Sepsis.
Sepsis
Hypoxia-Inducible Factor-1 ? Regulates the Expression of the Mitochondrial ATPase Inhibitor Protein (IF1) in Rat Liver.
Sepsis
IOX1 activity as sepsis therapy and an antibiotic against multidrug-resistant bacteria.
Sepsis
Melatonin restores the mitochondrial production of ATP in septic mice.
Sepsis
Recombinant ATPase of Virulent Aeromonas hydrophila Protects Channel Catfish Against Motile Aeromonas Septicemia.
Sepsis
Sepsis and burn complicated by sepsis alter cardiac transporter expression.
Sepsis
Septic cardiomyopathy in rat LPS-induced endotoxemia: relative contribution of cellular diastolic Ca(2+) removal pathways, myofibrillar biomechanics properties and action of the cardiotonic drug levosimendan.
Sepsis
The AI-discovered aetiology of COVID-19 and rationale of the irinotecan+ etoposide combination therapy for critically ill COVID-19 patients.
Sepsis
[Impairment in the phosphorylation of Ca(2+)-transport ATPase of rat liver endoplasmic reticulum during sepsis]
Severe Acute Respiratory Syndrome
Coronavirus interactions with the cellular autophagy machinery.
Severe Acute Respiratory Syndrome
Three dimensional model of severe acute respiratory syndrome coronavirus helicase ATPase catalytic domain and molecular design of severe acute respiratory syndrome coronavirus helicase inhibitors.
Shock, Septic
Activity of Na+ and K+ ATPase in the red blood cells of patients with septic shock.
Shock, Septic
Influence of endotoxin on myocardial calcium transport and the effect of augmented venous return.
Shock, Septic
Inosine infusion prevents mortality in endotoxic shock.
Shock, Septic
Relation between muscle Na+K+ ATPase activity and raised lactate concentrations in septic shock: a prospective study.
Shock, Septic
[Impairment in the phosphorylation of Ca(2+)-transport ATPase of rat liver endoplasmic reticulum during sepsis]
Sialic Acid Storage Disease
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Silicosis
[A study of the relation between energy transduction ATPase of mitochondrial membranes and experimental silicosis]
Skin Diseases
SERCA2-Controlled Ca(2+)-Dependent Keratinocyte Adhesion and Differentiation Is Mediated via the Sphingolipid Pathway: A Therapeutic Target for Darier's Disease.
Skin Diseases
[A comparative study of the quantitative distribution and ultrastructure of Langerhans cells in the epidermis of patients with chronic benign dermatoses and mycosis fungoides]
Sleep Deprivation
Comparison of Na-K ATPase activity in rat brain synaptosome under various conditions.
Sleep Deprivation
Effect of rapid eye movement sleep deprivation on rat brain Na-K ATPase activity.
Sleep Deprivation
Increased turnover of Na-K ATPase molecules in rat brain after rapid eye movement sleep deprivation.
Sleep Deprivation
Long term blocking of GABA-A receptor in locus coeruleus by bilateral microinfusion of picrotoxin reduced rapid eye movement sleep and increased brain Na-K ATPase activity in freely moving normally behaving rats.
Sleep Deprivation
Neural mechanism of rapid eye movement sleep generation: Cessation of locus coeruleus neurons is a necessity.
Sleep Deprivation
Possible mechanism of rapid eye movement sleep deprivation induced increase in Na-K ATPase activity.
Sleep Deprivation
Rapid Eye Movement Sleep Deprivation Associated Increase in Na-K ATPase Activity in the Rat Brain is Due to Noradrenaline Induced ?1-Adrenoceptor Mediated Increased ?-Subunit of the Enzyme.
Sleep Deprivation
REM sleep deprivation-induced noradrenaline stimulates neuronal and inhibits glial Na-K ATPase in rat brain: in vivo and in vitro studies.
Sleep Deprivation
Uncompetitive stimulation of rat brain Na-K ATPase activity by rapid eye movement sleep deprivation.
Sleep Deprivation
[Studies of cerebral ATPase activity in sleep deprivation in rats]
Sleep Initiation and Maintenance Disorders
Levofloxacin-induced delirium with psychotic features.
Small Cell Lung Carcinoma
A dual mechanism of action of the anticancer agent F 11782 on human topoisomerase II alpha.
Small Cell Lung Carcinoma
Altered subcellular distribution of topoisomerase II alpha in a drug-resistant human small cell lung cancer cell line.
Small Cell Lung Carcinoma
Altered topoisomerase II alpha in a drug-resistant small cell lung cancer cell line selected in VP-16.
Small Cell Lung Carcinoma
Antagonistic effect of aclarubicin on daunorubicin-induced cytotoxicity in human small cell lung cancer cells: relationship to DNA integrity and topoisomerase II.
Small Cell Lung Carcinoma
Differential expression of DNA topoisomerase II alpha and II beta genes between small cell and non-small cell lung cancer.
Small Cell Lung Carcinoma
Differential sensitivity patterns in small cell lung cancer cell lines: detection and circumvention of resistance to topoisomerase II targeting drugs.
Small Cell Lung Carcinoma
Effect of TOP2A and ERCC1 gene polymorphisms on the efficacy and toxicity of cisplatin and etoposide-based chemotherapy in small cell lung cancer patients.
Small Cell Lung Carcinoma
Efficacy of substituted 9-aminoacridine derivatives in small cell lung cancer.
Small Cell Lung Carcinoma
Expression of DNA topoisomerase IIalpha and topoisomerase IIbeta genes predicts survival and response to chemotherapy in patients with small cell lung cancer.
Small Cell Lung Carcinoma
Expression of Y box-binding protein-1 correlates with DNA topoisomerase IIalpha and proliferating cell nuclear antigen expression in lung cancer.
Small Cell Lung Carcinoma
Growth inhibitory effects of antifolates against an adriamycin-resistant human small cell lung cancer cell line.
Small Cell Lung Carcinoma
Human small cell lung cancer NYH cells resistant to the bisdioxopiperazine ICRF-187 exhibit a functional dominant Tyr165Ser mutation in the Walker A ATP binding site of topoisomerase II alpha.
Small Cell Lung Carcinoma
Human small cell lung cancer NYH cells selected for resistance to the bisdioxopiperazine topoisomerase II catalytic inhibitor ICRF-187 demonstrate a functional R162Q mutation in the Walker A consensus ATP binding domain of the alpha isoform.
Small Cell Lung Carcinoma
Loss of amino acids 1490Lys-Ser-Lys1492 in the COOH-terminal region of topoisomerase IIalpha in human small cell lung cancer cells selected for resistance to etoposide results in an extranuclear enzyme localization.
Small Cell Lung Carcinoma
Mitoxantrone-DNA binding and the induction of topoisomerase II associated DNA damage in multi-drug resistant small cell lung cancer cells.
Small Cell Lung Carcinoma
Multidrug resistance related genes and p53 expression in human non small cell lung cancer.
Small Cell Lung Carcinoma
Multidrug sensitivity phenotype of human lung cancer cells associated with topoisomerase II expression.
Small Cell Lung Carcinoma
Mutation frequency and spectrum in lymphocytes of small cell lung cancer patients receiving etoposide chemotherapy.
Small Cell Lung Carcinoma
Non-P-glycoprotein-mediated multidrug resistance in a small cell lung cancer cell line: evidence for decreased susceptibility to drug-induced DNA damage and reduced levels of topoisomerase II.
Small Cell Lung Carcinoma
Phase II multicenter trial of voreloxin as second-line therapy in chemotherapy-sensitive or refractory small cell lung cancer.
Small Cell Lung Carcinoma
Phase II study of dose-intense chemotherapy with sequential topoisomerase-targeting regimens with irinotecan/oxaliplatin followed by etoposide/carboplatin in chemotherapy naive patients with extensive small cell lung cancer.
Small Cell Lung Carcinoma
Point mutations of the topoisomerase IIalpha gene in patients with small cell lung cancer treated with etoposide.
Small Cell Lung Carcinoma
Quantitation of DNA topoisomerase II alpha messenger ribonucleic acid levels in a small cell lung cancer cell line and two drug resistant sublines using a polymerase chain reaction-aided transcript titration assay.
Small Cell Lung Carcinoma
Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small cell lung carcinoma cell line.
Small Cell Lung Carcinoma
Reduced expression of DNA topoisomerase II confers resistance to etoposide (VP-16) in small cell lung cancer cell lines established from a refractory tumor of a patient and by in vitro selection.
Small Cell Lung Carcinoma
Tirapazamine: a hypoxia-activated topoisomerase II poison.
Small Cell Lung Carcinoma
Topoisomerase II alpha gene expression in childhood acute lymphoblastic leukemia.
Small Cell Lung Carcinoma
Topoisomerase II as a target of VM-26 and 4'-(9-acridinylamino)methanesulfon-m-aniside in atypical multidrug resistant human small cell lung carcinoma cells.
Small Cell Lung Carcinoma
Topoisomerase II levels and drug response in small cell lung cancer.
Small Cell Lung Carcinoma
[Cytotoxic effect of topoisomerase II inhibitors against adriamycin- and etoposide-resistant small cell lung cancer sublines]
Smallpox
Kinetic Study of DNA Topoisomerases by Supercoiling-Dependent Fluorescence Quenching.
Smith-Magenis Syndrome
C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.
Smooth Muscle Tumor
TOP2A copy number and TOP2A expression in uterine benign smooth muscle tumours and leiomyosarcoma.
Smooth Muscle Tumor
[Topoisomerase IIalpha activity and tumor cell proliferation level from the degree of bromodeoxyuridine label in uterine body leiomyosarcoma].
Spastic Paraplegia, Hereditary
A novel insertion mutation in spastin gene is the cause of spastic paraplegia in a Chinese family.
Spastic Paraplegia, Hereditary
ESCRT-III-associated proteins and spastin inhibit protrudin-dependent polarised membrane traffic.
Spastic Paraplegia, Hereditary
Missense mutation of SPAST protein (I344K) results in loss of ATPase activity and prolonged the half-life, implicated in autosomal dominant hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Spastin, the most commonly mutated protein in hereditary spastic paraplegia interacts with Reticulon 1 an endoplasmic reticulum protein.
Spastic Paraplegia, Hereditary
SPG4 gene promoter regulation via Elk1 transcription factor.
Spermatic Cord Torsion
ATPase inhibition by omeprazole reveals role of heat shock proteins on testicular torsion.
Spinal Cord Injuries
Correlation of alterations on Na(+)-K+/Mg+2 ATPase activity, lipid peroxidation and ultrastructural findings following experimental spinal cord injury with and without intravenous methylprednisolone treatment.
Spinal Cord Injuries
Effects of naloxone on sodium- and potassium-activated and magnesium-dependent adenosine-5'-triphosphatase activity and lipid peroxidation and early ultrastructural findings after experimental spinal cord injury.
Spinal Cord Injuries
Effects of trapidil on ATPase, lipid peroxidation, and correlation with ultrastructure in experimental spinal cord injury.
Spinal Cord Injuries
Evaluation of a low dose administration of aspirin, dipyridamol and steroid. Therapeutic effects on motor function and protective effects on Na+-K+-activated ATPase activity against lipid peroxidation in an experimental model of spinal cord injury.
Spinal Cord Injuries
Inhibition of Na+-K+-activated ATPase activity following experimental spinal cord trauma.
Spinal Cord Injuries
Muscle fiber type-specific myofibrillar Ca(2+) ATPase activity after spinal cord injury.
Spinal Cord Injuries
Myofibrillar ATPase activity of feline muscle fibers expressing slow and fast myosin heavy chains.
Spinocerebellar Ataxias
Expanding the clinical and genetic heterogeneity of SPAX5.
Spinocerebellar Ataxias
Mitochondrial tRNALeu/Lys and ATPase 6/8 gene variations in spinocerebellar ataxias.
Spinocerebellar Ataxias
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Spinocerebellar Ataxias
Spinocerebellar ataxia 28: a novel AFG3L2 mutation in a German family with young onset, slow progression and saccadic slowing.
Squamous Cell Carcinoma of Head and Neck
Ammonium tetrathiomolybdate enhances the antitumor effect of cisplatin via the suppression of ATPase copper transporting beta in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Expression of ATP6V1C1 during oral carcinogenesis.
Squamous Cell Carcinoma of Head and Neck
Expression of drug resistance-related genes in head and neck squamous cell carcinomas and normal mucosa.
Squamous Cell Carcinoma of Head and Neck
Expression of multidrug resistance-related genes in oral squamous cell carcinomas.
Squamous Cell Carcinoma of Head and Neck
Immunohistochemical study of DNA topoisomerase I, DNA topoisomerase II alpha, p53, and Ki-67 in oral preneoplastic lesions and oral squamous cell carcinomas.
Squamous Cell Carcinoma of Head and Neck
Radioresistance in a human laryngeal squamous cell carcinoma cell line is associated with DNA methylation changes and topoisomerase II alpha.
Squamous Cell Carcinoma of Head and Neck
Sarcoendoplasmic reticulum Ca(2+) ATPase type 2 downregulated in human oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
The influence of hyaluronan-CD44 interaction on topoisomerase II activity and etoposide cytotoxicity in head and neck cancer.
Squamous Cell Carcinoma of Head and Neck
The significance of Epstein Barr Virus (EBV) & DNA Topoisomerase II alpha (DNA-Topo II alpha) immunoreactivity in normal oral mucosa, Oral Epithelial Dysplasia (OED) and Oral Squamous Cell Carcinoma (OSCC).
Squamous Cell Carcinoma of Head and Neck
Topoisomerase II trapping agent teniposide induces apoptosis and G2/M or S phase arrest of oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Topoisomerase IIa protein expression analysis in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Topoisomerase IIa Protein Expression Patterns in Laryngeal Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
[The expression of ki-67, topoIIalpha in laryngeal squamous cell carcinoma]
Staphylococcal Infections
New aminocoumarin antibiotics as gyrase inhibitors.
Staphylococcal Infections
Role of the extended alpha4 domain of Staphylococcus aureus gyrase A protein in determining low sensitivity to quinolones.
Starvation
Decreased glycolytic metabolism accelerates apoptosis in response to 2-acetyl furanonaphthoquinone in K1735 melanoma irrespective of bcl-2 overexpression.
Starvation
Depletion of topoisomerase II in isolated nuclei during a glucose-regulated stress response.
Starvation
Different cation stresses affect specifically osmotic root hydraulic conductance, involving aquaporins, ATPase and xylem loading of ions in Capsicum annuum, L. plants.
Starvation
Effect of dehydration, starvation and sodium deprivation on microsomal ATPase in the kidney.
Starvation
Effects of starvation, feeding, and time of day on the activity of proton transport adenosine triphosphatase in the parietal cells of the mouse gastric glands.
Starvation
Effects of thyroid hormones on contractility and cation transport in skeletal muscle.
Starvation
Gyrase inhibitors and thymine starvation disrupt the normal pattern of plasmid RK2 localization in Escherichia coli.
Starvation
In vivo activation of the yeast plasma membrane ATPase during nitrogen starvation. Identification of the regulatory domain that controls activation.
Starvation
Influence of age and short-term starvation on the ATPase activity in the developing rat brain.
Starvation
Interaction between glucose-regulated destruction domain of DNA topoisomerase IIalpha and MPN domain of Jab1/CSN5.
Starvation
Mechanisms of action of and resistance to ciprofloxacin.
Starvation
Multiple myeloma cells are protected against dexamethasone-induced apoptosis by insulin-like growth factors.
Starvation
Myofibrillar ATPase activity in the carp Cyprinus carpio: interactions between starvation and environmental temperature.
Starvation
Non-targeted profiling of semi-polar metabolites in Arabidopsis root exudates uncovers a role for coumarin secretion and lignification during the local response to phosphate limitation.
Starvation
Plasmid DNA supercoiling and survival in long-term cultures of Escherichia coli: role of NaCl.
Starvation
Proliferation- and cell cycle-dependent differences in expression of the 170 kilodalton and 180 kilodalton forms of topoisomerase II in NIH-3T3 cells.
Starvation
Proliferation-dependent regulation of DNA topoisomerase II in cultured human cells.
Starvation
Proteasome inhibition circumvents solid tumor resistance to topoisomerase II-directed drugs.
Starvation
Proton pump OsA8 is linked to phosphorus uptake and translocation in rice.
Starvation
Reduced level of ATF is correlated with transcriptional repression of DNA topoisomerase II alpha gene during TPA-induced differentiation of HL-60 cells.
Starvation
Regulatory coordination between two major intracellular homeostatic systems: heat shock response and autophagy.
Starvation
The exchange of calcium in larvae of the mosquito Aedes aegypti.
Starvation
Topoisomerase II expression in osseous tissue.
Starvation
Topoisomerase mutants and physiological conditions control supercoiling and Z-DNA formation in vivo.
Starvation
Transbilayer phosphatidylethanolamine movements in the yeast plasma membrane. Evidence for a protein-mediated, energy-dependent mechanism.
Starvation
VCP relocalization limits mitochondrial activity, GSH depletion and ferroptosis during starvation in PC3 prostate cancer cells.
Starvation
[Adaptive changes in activity of tonoplast H(+)-ATPase from the roots of tomato seedlings under phosphorus starvation]
Starvation
[Differential protein analysis on the root response of rice with high phosphorous uptake efficiency to low phosphorous stress].
Starvation
[Exogenous orthophosphate regulation of ATPase activity of E. coli cells]
Starvation
[Na,K-ATPase activity of erythrocytes of rats during prolonged starvation].
Status Epilepticus
Early life LiCl-pilocarpine-induced status epilepticus reduces acutely hippocampal glutamate uptake and Na(+)/K(+) ATPase activity.
Status Epilepticus
Neuronal-Specific Inhibition of Endoplasmic Reticulum Mg2+/Ca2+ ATPase Ca2+ Uptake in a Mixed Primary Hippocampal Culture Model of Status Epilepticus.
Status Epilepticus
Pilocarpine-induced status epilepticus causes N-methyl-D-aspartate receptor-dependent inhibition of microsomal Mg(2+)/Ca(2+) ATPase-mediated Ca(2+) uptake.
Status Epilepticus
Reduced cortical ecto-ATPase activity in rat brains during prolonged status epilepticus induced by sequential administration of lithium and pilocarpine.
Stomach Neoplasms
ATPase inhibitory factor 1 is a prognostic marker and contributes to proliferation and invasion of human gastric cancer cells.
Stomach Neoplasms
Clinical significance of UGT1A1 polymorphism and expression of ERCC1, BRCA1, TYMS, RRM1, TUBB3, STMN1 and TOP2A in gastric cancer.
Stomach Neoplasms
Coamplified and overexpressed genes at ERBB2 locus in gastric cancer.
Stomach Neoplasms
Comprehensive analysis of expression profiles of long non?coding RNAs with associated ceRNA network involved in gastric cancer progression.
Stomach Neoplasms
Differential sensitivity of human gastric cancer ATPase and normal gastric mucosa ATPase to the synthetic mammalian lignan analogue 2,3-dibenzylbutane-1,4-diol (hattalin).
Stomach Neoplasms
Effects of topoisomerase II inhibitors on gastric cancer cells characterized by different genetic lesions.
Stomach Neoplasms
Expression and potential roles of sodium-potassium ATPase and E-cadherin in human gastric adenocarcinoma.
Stomach Neoplasms
Expression and relationship between topoisomerase I and II alpha genes in tumor and normal tissues in esophageal, gastric and colon cancers.
Stomach Neoplasms
Expression of a molecular marker panel as a prognostic tool in gastric cancer patients treated postoperatively with docetaxel and irinotecan. A study of the Hellenic Cooperative Oncology Group.
Stomach Neoplasms
HER-2 amplification is highly homogenous in gastric cancer.
Stomach Neoplasms
HIF1?-dependent upregulation of ATAD2 promotes proliferation and migration of stomach cancer cells in response to hypoxia.
Stomach Neoplasms
Identification of Potential Biomarkers Involved in Gastric Cancer Through Integrated Analysis of Non-Coding RNA Associated Competing Endogenous RNAs Network.
Stomach Neoplasms
Intact long-type DupA protein in Helicobacter pylori is an ATPase involved in multifunctional biological activities.
Stomach Neoplasms
LncRNA FAM230B Promotes Gastric Cancer Growth and Metastasis by Regulating the miR-27a-5p/TOP2A Axis.
Stomach Neoplasms
Oncogenic potential of ATAD2 in stomach cancer and insights into the protein-protein interactions at its AAA?+?ATPase domain and bromodomain.
Stomach Neoplasms
Prognostic implications of the expression of erbB2, topoisomerase II alpha and thymidylate synthase in metastatic gastric cancer after fluorouracil-based therapy.
Stomach Neoplasms
Prognostic value of expression of Kit67, p53, TopoIIa and GSTP1 for curatively resected advanced gastric cancer patients receiving adjuvant paclitaxel plus capecitabine chemotherapy.
Stomach Neoplasms
Relationship between Topoisomerase II Alpha Overexpression and Prognosis in Chinese Gastric Cancer Patients.
Stomach Neoplasms
Semi-comprehensive analysis of gene amplification in gastric cancers using multiplex ligation-dependent probe amplification and fluorescence in situ hybridization.
Stomach Neoplasms
Significance of MDR-related proteins in the postoperative individualized chemotherapy of gastric cancer.
Stomach Neoplasms
Suppression of P-gp induced multiple drug resistance in a drug resistant gastric cancer cell line by overexpression of Fas.
Stomach Neoplasms
The association between chemosensitivity and Pgp, GST-? and Topo II expression in gastric cancer.
Stomach Neoplasms
The calcium pump PMCA4 prevents epithelial-mesenchymal transition by inhibiting NFATc1-ZEB1 pathway in gastric cancer.
Stomach Neoplasms
The predictors of response to neoadjuvant chemotherapy in patients with locally advanced gastric cancer.
Stomach Neoplasms
TOP2A, GGH, and PECAM1 are associated with hematogenous, lymph node, and peritoneal recurrence in stage II/III gastric cancer patients enrolled in the ACTS-GC study.
Stomach Neoplasms
Topoisomerase IIalpha gene amplification in gastric carcinomas: correlation with the HER2 gene. An immunohistochemical, immunoblotting, and multicolor fluorescence in situ hybridization study.
Stomach Neoplasms
Transcriptional Regulatory Network Analysis for Gastric Cancer Based on mRNA Microarray.
Stomach Neoplasms
Women with chronic follicular gastritis positive for Helicobacter pylori express lower levels of GKN1.
Stomach Neoplasms
[Effects of hydroxycamptothecin and teniposide on proliferation and apoptosis of gastric cancer cell line BGC-823]
Stomach Neoplasms
[Studies of multidrug resistance gene expression and apoptosis in stomach carcinoma]
Stomach Ulcer
A novel use of methylene blue as a pharmacological tool.
Stomach Ulcer
Effects of indomethacin and cold-stress on gastric acid secretion and ulceration. The effects of anti-acid secretory agents in rats.
Stomach Ulcer
Pharmacokinetics of omeprazole in cirrhotic patients.
Stroke
A kinetic model that explains the effect of inorganic phosphate on the mechanics and energetics of isometric contraction of fast skeletal muscle.
Stroke
ATP-dependent Interplay between Local and Global Conformational Changes in the Myosin Motor.
Stroke
Characterization of Empty Adenovirus Particles Assembled in the Absence of a Functional Adenovirus IVa2 Protein.
Stroke
Characterization of the cross-bridge force-generating step using inorganic phosphate and BDM in myofibrils from rabbit skeletal muscles.
Stroke
Direct measurements of the coordination of lever arm swing and the catalytic cycle in myosin V.
Stroke
Distribution of different fibre types in human skeletal muscles. I. Method for the preparation and analysis of cross-sections of whole tibialis anterior.
Stroke
Histone deacetylase activity mediates thermal plasticity in zebrafish (Danio rerio).
Stroke
Inhibition of membrane Na(+)-K+ Atpase of the brain, liver and RBC in rats administered di(2-ethyl hexyl) phthalate (DEHP) a plasticizer used in polyvinyl chloride (PVC) blood storage bags.
Stroke
Kinetic characterization of tail swing steps in the ATPase cycle of Dictyostelium cytoplasmic dynein.
Stroke
Low-dose cardiotonic steroids increase sodium-potassium ATPase activity that protects hippocampal slice cultures from experimental ischemia.
Stroke
Mechanochemical coupling in actomyosin energy transduction studied by in vitro movement assay.
Stroke
Mechanochemical Function of Myosin II: Investigation into the Recovery Stroke and ATP Hydrolysis.
Stroke
Motors in muscle: the function of conventional myosin II.
Stroke
Myosin cross-bridge mechanics: geometrical determinants for continuous sliding.
Stroke
On the regeneration of the actin-myosin power stroke in contracting muscle.
Stroke
Proposed ancestors of phage nucleic acid packaging motors (and cells).
Stroke
Rapid regeneration of the actin-myosin power stroke in contracting muscle.
Stroke
Role of the lever arm in the processive stepping of myosin V.
Stroke
Roles of the hydrophobic triplet in the motor domain of myosin in the interaction between myosin and actin.
Stroke
Single-molecule analysis of the actomyosin motor using nano-manipulation.
Stroke
Skeletal muscle fiber characteristics and oxidative capacity in hemiparetic stroke survivors.
Stroke
Small heat-shock proteins protect from heat-stroke-associated neurodegeneration.
Stroke
Structural Basis for the ATP-Induced Isomerization of Kinesin.
Stroke
Structural mechanism of the recovery stroke in the myosin molecular motor.
Stroke
The Contribution of the Elastic Reaction is Severely Underestimated in Studies on Myofibril Contraction.
Stroke
The gated gait of the processive molecular motor, myosin V.
Stroke
The hypertrophic cardiomyopathy myosin mutation R453C alters ATP binding and hydrolysis of human cardiac ?-myosin.
Stroke
The role of the blood-brain barrier Na-K-2Cl cotransporter in stroke.
Stroke
The stroke size of myosins: a reevaluation.
Stroke
The structural coupling between ATPase activation and recovery stroke in the myosin II motor.
Stroke
The working stroke upon myosin-nucleotide complexes binding to actin.
Stroke
Unraveling a Force-Generating Allosteric Pathway of Actomyosin Communication Associated with ADP and Pi Release.
Stroke
Using optical tweezers to relate the chemical and mechanical cross-bridge cycles.
Stroke
Viral and cellular SOS-regulated motor proteins: dsDNA translocation mechanisms with divergent functions.
Stroke
[ATPase activity and erythrocyte levels of potassium, sodium, calcium and cholesterol and its fractions and esters in patients in the acute period of cerebral stroke]
Stroke
[Change in prostaglandin levels and ATPase activity of cardiac membrane fractions during the formation of cerebral hematomas in animals with a hereditary predisposition to stroke]
Stroke
[The effect of carbacyclin on the ATPase activity in the heart of normotensive and spontaneously hypertensive rats with a hereditary susceptibility to stroke]
Stupor
Short chain fatty acid inhibition of rat brain Na-K adenosine triphosphatase.
Subacute Sclerosing Panencephalitis
Hypothalamic digoxin-mediated model for subacute sclerosing panencephalitis.
Subarachnoid Hemorrhage
Effects of high-dose methylprednisolone on Na(+)-K+ ATPase and lipid peroxidation after experimental subarachnoid hemorrhage.
Subarachnoid Hemorrhage
The effect of deferoxamine on brain lipid peroxide levels and Na-K ATPase activity following experimental subarachnoid hemorrhage.
Superinfection
A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa.
Surgical Wound Infection
Design and development of some thiazole-based flavanoids as novel antibacterial against pathogens causing surgical site infection for possible benefit in bone trauma via inhibition of DNA gyrase.
Syphilis
Mitochondrial antibodies in chronic liver diseases and connective tissue disorders: further characterization of the autoantigens.
Tachycardia
Altered sarcolemmal calcium channel density and Ca(2+)-pump ATPase activity in tachycardia heart failure.
Tangier Disease
Endoneurial ATPase activity in Tangier disease and other peripheral neuropathies.
Tauopathies
Chemical manipulation of hsp70 ATPase activity regulates tau stability.
Teratocarcinoma
A study of topoisomerase activity in human testicular cancers.
Teratocarcinoma
[Effect of inhibitors of topoisomerases and poly(ADP-ribosylation) on homologous and non-homologous integration of exogenous DNA in genes of mammalian somatic cells]
Teratoma
Inhibition of DNA Topoisomerase II Selectively Reduces the Threat of Tumorigenicity Following Induced Pluripotent Stem Cell-Based Myocardial Therapy.
Teratoma
Topoisomerase II alpha expression in testicular germ cell tumors.
Testicular Neoplasms
A study of topoisomerase activity in human testicular cancers.
Testicular Neoplasms
ICRF-187 rescue in etoposide treatment in vivo. A model targeting high-dose topoisomerase II poisons to CNS tumors.
Testicular Neoplasms
Mutation frequency and spectrum in lymphocytes of small cell lung cancer patients receiving etoposide chemotherapy.
Testicular Neoplasms
Therapy related leukemias: susceptibility, prevention and treatment.
Tetanus
Metabolic changes associated with the slowing of relaxation in fatigued mouse muscle.
Tetanus
Modulation of ion gradients and glutamate release in cultured cerebellar granule cells by ouabain.
Tetanus
Muscle and serum adenosine triphosphatase in patients suffering from tetanus.
Thiamine Deficiency
[Effect of thiamine deficiency and excess on activity of NA+, K+, Mg2+-ATPase in plasma membranes of rat liver]
Thrombocytopenia
Intra-erythrocytary enzymes before and after splenectomy.
Thrombosis
Lymphangioma and congenital pulmonary lymphangiectasis: a histologic, immunohistochemical, and clinicopathologic comparison.
Thrombosis
Oral L-arginine administration does not inhibit thrombosis on an experimental model of arterial thrombosis: the effect on the apyrasic activity of the arterial wall.
Thymoma
Prognostic effect of class III ?-tubulin and Topoisomerase-II in patients with advanced thymic carcinoma who received combination chemotherapy, including taxanes or topoisomerase-II inhibitors.
Thymoma
Successful salvage chemotherapy with amrubicin for invasive thymoma associated with myasthenia gravis.
Thymoma
Tumor heterogeneity at protein level as an independent prognostic factor in endometrial cancer.
Thymus Neoplasms
Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency.
Thyroid Cancer, Papillary
Comparative topoisomerase IIa and ki 67 protein expression in papillary thyroid carcinoma based on tissue microarrays and image analysis.
Thyroid Cancer, Papillary
Prognostic Value and Significant Pathway Exploration Associated with TOP2A Involved in Papillary Thyroid Cancer.
Thyroid Cancer, Papillary
Topoisomerase II alpha and telomerase expression in papillary thyroid carcinomas.
Thyroid Carcinoma, Anaplastic
Lack of a point mutation of human DNA topoisomerase II in multidrug-resistant anaplastic thyroid carcinoma cell lines.
Thyroid Diseases
Effects of thyroid hormones on contractility and cation transport in skeletal muscle.
Thyroid Diseases
Evaluation of peripheral metabolic status by determination of Na-K ATPase pump activity in circulating erythrocytes in patients with thyroid diseases and nonthyroidal illnesses.
Thyroid Diseases
p27kip1 expression distinguishes papillary hyperplasia in Graves' disease from papillary thyroid carcinoma.
Thyroid Neoplasms
Integrated Bioinformatics Analysis of Hub Genes and Pathways in Anaplastic Thyroid Carcinomas.
Thyroid Neoplasms
Prognostic Value and Significant Pathway Exploration Associated with TOP2A Involved in Papillary Thyroid Cancer.
Thyrotoxicosis
Contractile, biochemical, and histochemical properties of thyrotoxic rat soleus muscle.
Thyrotoxicosis
Erythrocyte sodium-potassium pump in thyrotoxic periodic paralysis.
Thyrotoxicosis
[Effect of thyroxine on the function of rabbit skeletal muscle sarcoplasmic reticulum]
Tics
Transporter-interfering chemicals inhibit P-glycoprotein of yellowfin tuna (Thunnus albacares).
Tinea
PCR and PCR-RFLP techniques targeting the DNA topoisomerase II gene for rapid clinical diagnosis of the etiologic agent of dermatophytosis.
Tonsillitis
Divalent cation-activated-ATPase and ecto 5'-nucleotidase activities in chronic tonsillitis.
Tourette Syndrome
Hypothalamic digoxin deficiency in obsessive compulsive disorder and la Tourette's syndrome.
transaldolase deficiency
Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency.
Tremor
Acute chlordecone toxicity in rats: a relationship between tremor and ATPase activities.
Tremor
Involvement of brain GABAAR-coupled Cl-/HCO3--ATPase in phenol-induced the head-twitching and tremor responses in rats.
Tricuspid Valve Insufficiency
[Secondary tricuspid insufficiency and right atrial myosin ATPase activity]
Triple Negative Breast Neoplasms
Autophagy-Dependent Sensitization of Triple-Negative Breast Cancer Models to Topoisomerase II Poisons by Inhibition of the Nucleosome Remodeling Factor.
Triple Negative Breast Neoplasms
Clinical significance of topoisomerase 2A expression and gene change in operable invasive breast cancer.
Triple Negative Breast Neoplasms
Combinatorial therapy for triple negative breast cancer using hyperstar polymer-based nanoparticles.
Triple Negative Breast Neoplasms
Expression of p53, Ki-67, E-cadherin, N-cadherin and TOP2A in triple-negative breast cancer.
Triple Negative Breast Neoplasms
Multi-Omics Characterization of the 4T1 Murine Mammary Gland Tumor Model.
Triple Negative Breast Neoplasms
Quantum dot-based immunofluorescent imaging and quantitative detection of TOP2A and prognostic value in triple-negative breast cancer.
Triple Negative Breast Neoplasms
The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation.
Triple Negative Breast Neoplasms
Topoisomerase II ? Gene alteration in Triple Negative Breast Cancer and Its Predictive Role for Anthracycline-Based Chemotherapy (Egyptian NCI Patients)
Triple Negative Breast Neoplasms
[Relevance between TOP2A, EGFR gene expression and efficacy of docetaxel plus epirubicin as neoadjuvant chemotherapy in triple negative breast cancer patients].
Truncus Arteriosus, Persistent
Actin and myosin isoforms in aneural and malformed chick hearts.
Trypanosomiasis
Brain Na+ K+ ATPase and cholesterol in acute experimental trypanosomiasis.
Tuberculosis
A Comprehensive Review on DNA Gyrase Inhibitors.
Tuberculosis
A computational model of the inhibition of Mycobacterium tuberculosis ATPase by a new drug candidate R207910.
Tuberculosis
A monoclonal antibody that inhibits mycobacterial DNA gyrase by a novel mechanism.
Tuberculosis
A novel inhibitor of gyrase B is a potent drug candidate for treatment of tuberculosis and nontuberculosis mycobacterial infections.
Tuberculosis
A novel resistance mutation in eccC5 of the ESX-5 secretion system confers ofloxacin resistance in Mycobacterium tuberculosis.
Tuberculosis
A systematic review of gyrase mutations associated with fluoroquinolone-resistant Mycobacterium tuberculosis and a proposed gyrase numbering system.
Tuberculosis
ABC transporter ATPase of Chlamydophila pneumoniae as a potential vaccine candidate.
Tuberculosis
Activity of 2-(quinolin-4-yloxy)acetamides in mycobacterium tuberculosis clinical isolates and identification of their molecular target by whole genome sequencing.
Tuberculosis
Activity of the mycobacterial proteasomal ATPase mpa is reversibly regulated by pupylation.
Tuberculosis
ADP-dependent conformational changes distinguish Mycobacterium tuberculosis SecA2 from SecA1.
Tuberculosis
An efficient synthesis and biological screening of benzofuran and benzo[d]isothiazole derivatives for Mycobacterium tuberculosis DNA GyrB inhibition.
Tuberculosis
Anti-Mycobacterium tuberculosis Activity of Esters of Quinoxaline 1,4-Di-N-Oxide.
Tuberculosis
Anti-tubercular drug designing by structure based screening of combinatorial libraries.
Tuberculosis
Antimicrobial agent resistance in mycobacteria: molecular genetic insights.
Tuberculosis
Antimycobacterial activities of novel 1-(cyclopropyl/tert-butyl/4-fluorophenyl)-1,4-dihydro- 6-nitro-4-oxo-7-(substituted secondary amino)-1,8-naphthyridine-3-carboxylic acid.
Tuberculosis
Antimycobacterial activities of novel 2-(sub)-3-fluoro/nitro-5,12-dihydro-5-oxobenzothiazolo[3,2-a]quinoline-6-carboxylic acid.
Tuberculosis
Antimycobacterial activities of novel fluoroquinolones.
Tuberculosis
Antimycobacterial and phototoxic evaluation of novel 6-fluoro/nitro-4-oxo-7-(sub)-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid.
Tuberculosis
Assays, surrogates, and alternative technologies for a TB lead identification program targeting DNA gyrase ATPase.
Tuberculosis
ATPase activity of Mycobacterium tuberculosis SecA1 and SecA2 proteins and its importance for SecA2 function in macrophages.
Tuberculosis
B-subunit of phosphate-specific transporter from Mycobacterium tuberculosis is a thermostable ATPase.
Tuberculosis
Benzimidazoles: novel mycobacterial gyrase inhibitors from scaffold morphing.
Tuberculosis
Benzothiazinone-piperazine derivatives as efficient Mycobacterium tuberculosis DNA gyrase inhibitors.
Tuberculosis
Bimodal Actions of a Naphthyridone/Aminopiperidine-Based Antibacterial That Targets Gyrase and Topoisomerase IV.
Tuberculosis
Binding profile of protein-ligand inhibitor complex and structure based design of new potent compounds via computer-aided virtual screening.
Tuberculosis
Biochemical and biophysical characterization of nucleotide binding domain of Trehalose transporter from Mycobacterium tuberculosis.
Tuberculosis
Calcium ATPase signaling: A must include mechanism in the Radar of therapeutics development against Tuberculosis.
Tuberculosis
Chemical classes targeting energy supplying GyrB domain of Mycobacterium tuberculosis.
Tuberculosis
Cloning and nucleotide sequence of Mycobacterium tuberculosis gyrA and gyrB genes and detection of quinolone resistance mutations.
Tuberculosis
ClpX Is Essential and Activated by Single-Strand DNA Binding Protein in Mycobacteria.
Tuberculosis
Conditional Silencing by CRISPRi Reveals the Role of DNA Gyrase in Formation of Drug-Tolerant Persister Population in Mycobacterium tuberculosis.
Tuberculosis
Core component EccB1 of the Mycobacterium tuberculosis type VII secretion system is a periplasmic ATPase.
Tuberculosis
Correction: The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1.
Tuberculosis
Crystal structure of DNA gyrase B' domain sheds lights on the mechanism for T-segment navigation.
Tuberculosis
Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase.
Tuberculosis
Crystal structure of the DNA gyrase GyrA N-terminal domain from Mycobacterium tuberculosis.
Tuberculosis
Crystal structure of the N-terminal domain of EccA1 ATPase from the ESX-1 secretion system of Mycobacterium tuberculosis.
Tuberculosis
Crystal structures of Mycobacterium tuberculosis RecA and its complex with ADP-AlF(4): implications for decreased ATPase activity and molecular aggregation.
Tuberculosis
Crystallization and preliminary crystallographic studies of Mycobacterium tuberculosis DNA gyrase B C-terminal domain, part of the enzyme reaction core.
Tuberculosis
Crystallographic observation of the movement of the membrane-distal domain of the T7SS core component EccB1 from Mycobacterium tuberculosis.
Tuberculosis
CtpB is a plasma membrane copper (I) transporting P-type ATPase of Mycobacterium tuberculosis.
Tuberculosis
Description of compensatory gyrA mutations restoring fluoroquinolone susceptibility in Mycobacterium tuberculosis.
Tuberculosis
Design and synthesis of novel quinoline-aminopiperidine hybrid analogues as Mycobacterium tuberculosis DNA gyraseB inhibitors.
Tuberculosis
Design, synthesis and activity against Toxoplasma gondii, Plasmodium spp., and Mycobacterium tuberculosis of new 6-fluoroquinolones.
Tuberculosis
Design, synthesis, biological evaluation of substituted benzofurans as DNA gyraseB inhibitors of Mycobacterium tuberculosis.
Tuberculosis
Development of 2-amino-5-phenylthiophene-3-carboxamide derivatives as novel inhibitors of Mycobacterium tuberculosis DNA GyrB domain.
Tuberculosis
Development of acridine derivatives as selective Mycobacterium tuberculosis DNA gyrase inhibitors.
Tuberculosis
Development of novel N-linked aminopiperidine-based mycobacterial DNA gyrase B inhibitors: Scaffold hopping from known antibacterial leads.
Tuberculosis
Diagnostic accuracy of droplet digital PCR analysis of cerebrospinal fluid for tuberculous meningitis in adult patients.
Tuberculosis
Discovery of Novel Mycobacterial DNA Gyrase B Inhibitors: In Silico and In Vitro Biological Evaluation.
Tuberculosis
Discovery of novel phthalimide analogs: Synthesis, antimicrobial and antitubercular screening with molecular docking studies.
Tuberculosis
DNA gyrase genes in Mycobacterium tuberculosis: a single operon driven by multiple promoters.
Tuberculosis
DNA gyrase inhibition assays are necessary to demonstrate fluoroquinolone resistance secondary to gyrB mutations in Mycobacterium tuberculosis.
Tuberculosis
DNA topoisomerase I and DNA gyrase as targets for TB therapy.
Tuberculosis
Double Mutants in DNA Gyrase Lead to Ofloxacin Resistance in Mycobacterium tuberculosis.
Tuberculosis
Dynamics of fluoroquinolones induced resistance in DNA gyrase of Mycobacterium tuberculosis.
Tuberculosis
Effect of PEG and water-soluble chitosan coating on moxifloxacin-loaded PLGA long-circulating nanoparticles.
Tuberculosis
Effects of conserved residues and naturally occurring mutations on Mycobacterium tuberculosis RecG helicase activity.
Tuberculosis
EmbR, a regulatory protein with ATPase activity, is a substrate of multiple serine/threonine kinases and phosphatase in Mycobacterium tuberculosis.
Tuberculosis
Enabling the (3 + 2) cycloaddition reaction in assembling newer anti-tubercular lead acting through the inhibition of the gyrase ATPase domain: lead optimization and structure activity profiling.
Tuberculosis
Engineering another class of anti-tubercular lead: Hit to lead optimization of an intriguing class of gyrase ATPase inhibitors.
Tuberculosis
Enzymatic activities and DNA substrate specificity of Mycobacterium tuberculosis DNA helicase XPB.
Tuberculosis
Evaluation of antimycobacterial and DNA gyrase inhibition of fluoroquinolone derivatives.
Tuberculosis
Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis.
Tuberculosis
Exploring the gyrase ATPase domain for tailoring newer anti-tubercular drugs: hit to lead optimization of a novel class of thiazole inhibitors.
Tuberculosis
Extending GyrB QRDR definition in Mycobacterium tuberculosis DNA gyrase for assessing FQ resistance in M. tuberculosis.
Tuberculosis
Extending the N-linked aminopiperidine class to the mycobacterial gyrase domain: pharmacophore mapping from known antibacterial leads.
Tuberculosis
First functional characterization of a singly expressed bacterial type II topoisomerase: the enzyme from Mycobacterium tuberculosis.
Tuberculosis
Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase.
Tuberculosis
Fluoroquinolone resistance associated with specific gyrase mutations in clinical isolates of multidrug-resistant Mycobacterium tuberculosis.
Tuberculosis
Fluoroquinolone resistance detection in Mycobacterium tuberculosis with locked nucleic acid probe real-time PCR.
Tuberculosis
Functional analysis of DNA gyrase mutant enzymes carrying mutations at position 88 in the A subunit found in clinical strains of Mycobacterium tuberculosis resistant to fluoroquinolones.
Tuberculosis
Functional interactions between gyrase subunits are optimized in a species-specific manner.
Tuberculosis
Gatifloxacin derivatives: synthesis, antimycobacterial activities, and inhibition of Mycobacterium tuberculosis DNA gyrase.
Tuberculosis
Glutamate racemase from Mycobacterium tuberculosis inhibits DNA gyrase by affecting its DNA-binding.
Tuberculosis
gyrA/B fluoroquinolone resistance allele profiles amongst Mycobacterium tuberculosis isolates from mainland China.
Tuberculosis
Gyrase ATPase domain as an antitubercular drug discovery platform: structure-based design and lead optimization of nitrothiazolyl carboxamide analogues.
Tuberculosis
Gyrase Mutations Are Associated with Variable Levels of Fluoroquinolone Resistance in Mycobacterium tuberculosis.
Tuberculosis
Gyrase mutations in laboratory-selected, fluoroquinolone-resistant mutants of Mycobacterium tuberculosis H37Ra.
Tuberculosis
High Proportion of Fluoroquinolone-Resistant M. tuberculosis Isolates with Novel Gyrase Polymorphisms and a gyrA Region Associated with Fluoroquinolone Susceptibility.
Tuberculosis
Homing events in the gyrA gene of some mycobacteria.
Tuberculosis
Identification of chebulinic acid as potent natural inhibitor of M. tuberculosis DNA gyrase and molecular insights into its binding mode of action.
Tuberculosis
Identification of iron-regulated proteins of Mycobacterium tuberculosis and cloning of tandem genes encoding a low iron-induced protein and a metal transporting ATPase with similarities to two-component metal transport systems.
Tuberculosis
Identification of promising DNA GyrB inhibitors for Tuberculosis using pharmacophore-based virtual screening, molecular docking and molecular dynamics studies.
Tuberculosis
Impact of fluoroquinolone resistance on bactericidal and sterilizing activity of a moxifloxacin-containing regimen in murine tuberculosis.
Tuberculosis
Impact of the E540V amino acid substitution in GyrB of Mycobacterium tuberculosis on quinolone resistance.
Tuberculosis
In silico designing of domain B selective gyrase inhibitors for effective treatment of resistant tuberculosis.
Tuberculosis
In silico study directed towards identification of the key structural features of GyrB inhibitors targeting MTB DNA gyrase: HQSAR, CoMSIA and molecular dynamics simulations.
Tuberculosis
In vitro antituberculosis activities of ACH-702, a novel isothiazoloquinolone, against quinolone-susceptible and quinolone-resistant isolates.
Tuberculosis
Inhibition of DNA gyrase activity by Mycobacterium smegmatis MurI.
Tuberculosis
Inhibition of Mycobacterium tuberculosis topoisomerase I by m-AMSA, a eukaryotic type II topoisomerase poison.
Tuberculosis
Inhibitory activity of quinolones against DNA gyrase of Mycobacterium tuberculosis.
Tuberculosis
Insights into Pyrazinamidase and DNA Gyrase Protein Structures in Resistant and Susceptible Clinical Isolates of Mycobacterium tuberculosis.
Tuberculosis
Intrinsic contributions of polar amino acid residues toward thermal stability of an ABC-ATPase of mesophilic origin.
Tuberculosis
Introducing Broadened Antibacterial Activity to Rhodanine Derivatives Targeting Enoyl-Acyl Carrier Protein Reductase.
Tuberculosis
Mannich reaction derivatives of novobiocin with modulated physiochemical properties and their antibacterial activities.
Tuberculosis
Mechanism of Action of Mycobacterium tuberculosis Gyrase Inhibitors: A Novel Class of Gyrase Poisons.
Tuberculosis
Mechanisms for defining supercoiling set point of DNA gyrase orthologs: II. The shape of the GyrA subunit C-terminal domain (CTD) is not a sole determinant for controlling supercoiling efficiency.
Tuberculosis
Mechanisms of fluoroquinolone monoresistance in Mycobacterium tuberculosis.
Tuberculosis
Mechanisms of fluoroquinolone resistance in Mycobacterium tuberculosis.
Tuberculosis
Modulation of Mycobacterium tuberculosis DnaA protein-adenine-nucleotide interactions by acidic phospholipids.
Tuberculosis
Molecular Characterization of Fluoroquinolone Resistance in Mycobacterium tuberculosis: Functional Analysis of gyrA Mutant at Position 74.
Tuberculosis
Molecular cloning of gyrA and gyrB genes of Mycobacterium tuberculosis: analysis of nucleotide sequence.
Tuberculosis
Molecular modeling of Mycobacterium tuberculosis DNA gyrase and its molecular docking study with gatifloxacin inhibitors.
Tuberculosis
Monoclonal antibodies to mycobacterial DNA gyrase A inhibit DNA supercoiling activity.
Tuberculosis
Moonlighting function of glutamate racemase from Mycobacterium tuberculosis: racemization and DNA gyrase inhibition are two independent activities of the enzyme.
Tuberculosis
Mutagenesis in the alpha3alpha4 GyrA helix and in the Toprim domain of GyrB refines the contribution of Mycobacterium tuberculosis DNA gyrase to intrinsic resistance to quinolones.
Tuberculosis
Mutation in clpC1 encoding an ATP-dependent ATPase involved in protein degradation is associated with pyrazinamide resistance in Mycobacterium tuberculosis.
Tuberculosis
Mycobacterium marinum SecA2 Promotes Stable Granulomas and Induces Tumor Necrosis Factor Alpha In Vivo.
Tuberculosis
Mycobacterium Tuberculosis (MTB) GyrB inhibitors: An attractive approach for developing novel drugs against TB.
Tuberculosis
Mycobacterium tuberculosis Calcium Pump CtpF Modulates the Autophagosome in an mTOR-Dependent Manner.
Tuberculosis
Mycobacterium tuberculosis cell division protein, FtsE, is an ATPase in dimeric form.
Tuberculosis
Mycobacterium tuberculosis ClpC1: characterization and role of the N-terminal domain in its function.
Tuberculosis
Mycobacterium tuberculosis DNA gyrase as a target for drug discovery.
Tuberculosis
Mycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motion.
Tuberculosis
Mycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activity.
Tuberculosis
Mycobacterium tuberculosis Gyrase Inhibitors as a New Class of Antitubercular Drugs.
Tuberculosis
Mycobacterium tuberculosis infection of domesticated Asian elephants, Thailand.
Tuberculosis
Mycobacterium tuberculosis RecA intein, a LAGLIDADG homing endonuclease, displays Mn(2+) and DNA-dependent ATPase activity.
Tuberculosis
Mycobacterium tuberculosis UvrD1 and UvrA proteins suppress DNA strand exchange promoted by cognate and noncognate RecA proteins.
Tuberculosis
Noncytotoxic Pyrrolobenzodiazepine-Ciprofloxacin Conjugate with Activity against Mycobacterium tuberculosis.
Tuberculosis
Novel amide and sulphonamide derivatives of 6-(piperazin-1-yl)phenanthridine as potent Mycobacterium tuberculosis H37Rv inhibitors.
Tuberculosis
Novel gyrase mutations in quinolone-resistant and -hypersusceptible clinical isolates of Mycobacterium tuberculosis: functional analysis of mutant enzymes.
Tuberculosis
Novel N-linked aminopiperidine-based gyrase inhibitors with improved hERG and in vivo efficacy against Mycobacterium tuberculosis.
Tuberculosis
Novel ofloxacin derivatives: synthesis, antimycobacterial and toxicological evaluation.
Tuberculosis
Novel, potent, orally bioavailable and selective mycobacterial ATP synthase inhibitors that demonstrated activity against both replicating and non-replicating M. tuberculosis.
Tuberculosis
Nucleotide-induced conformational change in the catalytic subunit of the phosphate-specific transporter from M. tuberculosis: implications for the ATPase structure.
Tuberculosis
Optimization of pyrrolamides as mycobacterial GyrB ATPase inhibitors: structure-activity relationship and in vivo efficacy in a mouse model of tuberculosis.
Tuberculosis
Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity.
Tuberculosis
Partial complementation of Sinorhizobium meliloti bacA mutant phenotypes by the Mycobacterium tuberculosis BacA protein.
Tuberculosis
Pharmacophore modeling and molecular dynamics approach to identify putative DNA Gyrase B inhibitors for resistant tuberculosis.
Tuberculosis
Phenotypic and genotypic characterization of levofloxacin- and moxifloxacin-resistant Mycobacterium tuberculosis clinical isolates in southern China.
Tuberculosis
Probing the functional tolerance of the b subunit of Escherichia coli ATP synthase for sequence manipulation through a chimera approach.
Tuberculosis
Prokaryotic ubiquitin-like protein pup is intrinsically disordered.
Tuberculosis
Pup, a prokaryotic ubiquitin-like protein, is an intrinsically disordered protein.
Tuberculosis
Purification, crystallization and preliminary X-ray crystallographic studies of the Mycobacterium tuberculosis DNA gyrase ATPase domain.
Tuberculosis
Purification, crystallization and preliminary X-ray crystallographic studies of the Mycobacterium tuberculosis DNA gyrase CTD.
Tuberculosis
Purification, crystallization and preliminary X-ray diffraction experiments on the breakage-reunion domain of the DNA gyrase from Mycobacterium tuberculosis.
Tuberculosis
Recognition of DNA Supercoil Geometry by Mycobacterium tuberculosis Gyrase.
Tuberculosis
Regulation of a nickel-cobalt efflux system and nickel homeostasis in a soil actinobacterium Streptomyces coelicolor.
Tuberculosis
Regulation of the gyr operon of Mycobacterium tuberculosis by overlapping promoters, DNA topology, and reiterative transcription.
Tuberculosis
Replacement of cardiotoxic aminopiperidine linker with piperazine moiety reduces cardiotoxicity? Mycobacterium tuberculosis novel bacterial topoisomerase inhibitors.
Tuberculosis
Resistance-conferring mutations on whole-genome sequencing of fluoroquinolone-resistant and -susceptible M. tuberculosis isolates: a proposed threshold for identifying resistance.
Tuberculosis
Restricted structural gene polymorphism in the Mycobacterium tuberculosis complex indicates evolutionarily recent global dissemination.
Tuberculosis
Role of gyrB Mutations in Pre-extensively and Extensively Drug-Resistant Tuberculosis in Thai Clinical Isolates.
Tuberculosis
Rv2477c is an antibiotic-sensitive manganese-dependent ABC-F ATPase in Mycobacterium tuberculosis.
Tuberculosis
Rv3868 (EccA1), an essential component of the Mycobacterium tuberculosis ESX-1 secretion system, is thermostable.
Tuberculosis
Schiff bases of indoline-2,3-dione: potential novel inhibitors of Mycobacterium tuberculosis (Mtb) DNA gyrase.
Tuberculosis
Sensitivities of ciprofloxacin-resistant Mycobacterium tuberculosis clinical isolates to fluoroquinolones: role of mutant DNA gyrase subunits in drug resistance.
Tuberculosis
Sequence analysis, purification, and study of inhibition by 4-quinolones of the DNA gyrase from Mycobacterium smegmatis.
Tuberculosis
Should moxifloxacin be used for the treatment of extensively drug-resistant tuberculosis? An answer from a murine model.
Tuberculosis
Solution structure and refolding of the Mycobacterium tuberculosis pentapeptide repeat protein MfpA.
Tuberculosis
Specific gyrA gene mutations predict poor treatment outcome in MDR-TB.
Tuberculosis
Strategies for the Discovery and Development of New Antibiotics from Natural Products: Three Case Studies.
Tuberculosis
Structural and ATPase activity analysis of nucleotide binding domain of Rv3870 enzyme of M. tuberculosis ESX-1 system.
Tuberculosis
Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase.
Tuberculosis
Structure-based drug repurposing to inhibit the DNA gyrase of Mycobacterium tuberculosis.
Tuberculosis
Structure-Guided Discovery of Antitubercular Agents That Target the Gyrase ATPase Domain.
Tuberculosis
Synthesis and antimicrobial evaluation of new nitric oxide-donating fluoroquinolone/oxime hybrids.
Tuberculosis
Synthesis and antimycobacterial activities of novel 6-nitroquinolone-3-carboxylic acids.
Tuberculosis
Synthesis and antimycobacterial evaluation of newer 1-cyclopropyl-1,4-dihydro-6-fluoro-7-(substituted secondary amino)-8-methoxy-5-(sub)-4-oxoquinoline-3-carboxylic acids.
Tuberculosis
Synthesis and antimycobacterial evaluation of various 7-substituted ciprofloxacin derivatives.
Tuberculosis
Synthesis and biological evaluation of moxifloxacin-acetyl-1,2,3-1H-triazole-methylene-isatin hybrids as potential anti-tubercular agents against both drug-susceptible and drug-resistant Mycobacterium tuberculosis strains.
Tuberculosis
Synthesis, antimycobacterial activities and phototoxic evaluation of 5H-thiazolo[3,2-a]quinoline-4-carboxylic acid derivatives.
Tuberculosis
Targeting DNA Gyrase to Combat Mycobacterium tuberculosis: An Update.
Tuberculosis
The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring.
Tuberculosis
The Cyclic Peptide Ecumicin Targeting ClpC1 Is Active against Mycobacterium tuberculosis In Vivo.
Tuberculosis
The dimer state of GyrB is an active form: implications for the initial complex assembly and processive strand passage.
Tuberculosis
The DosR Dormancy Regulator of Mycobacterium tuberculosis Stimulates the Na(+)/K (+) and Ca (2+) ATPase Activities in Plasma Membrane Vesicles of Mycobacteria.
Tuberculosis
The ESAT-6/CFP-10 secretion system of Mycobacterium marinum modulates phagosome maturation.
Tuberculosis
The ESX-5 associated eccB-EccC locus is essential for Mycobacterium tuberculosis viability.
Tuberculosis
The intrinsic ATPase activity of Mycobacterium tuberculosis DnaA promotes rapid oligomerization of DnaA on oriC.
Tuberculosis
The key DNA-binding residues in the C-terminal domain of Mycobacterium tuberculosis DNA gyrase A subunit (GyrA).
Tuberculosis
The Molecular Genetics of Fluoroquinolone Resistance in Mycobacterium tuberculosis.
Tuberculosis
The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1.
Tuberculosis
The Mycobacterium tuberculosis DNA gyrase possesses two functional GyrA-boxes.
Tuberculosis
The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action.
Tuberculosis
The pentapeptide repeat proteins MfpAMt and QnrB4 exhibit opposite effects on DNA gyrase catalytic reactions and on the ternary gyrase-DNA-quinolone complex.
Tuberculosis
The role of Ca2+ in the activity of Mycobacterium tuberculosis DNA gyrase.
Tuberculosis
The structural modeling of the interaction between levofloxacin and the Mycobacterium tuberculosis gyrase catalytic site sheds light on the mechanisms of fluoroquinolones resistant tuberculosis in Colombian clinical isolates.
Tuberculosis
Thiazole-aminopiperidine hybrid analogues: design and synthesis of novel Mycobacterium tuberculosis GyrB inhibitors.
Tuberculosis
Three-component, one-pot synthesis of anthranilamide Schiff bases bearing 4-aminoquinoline moiety as Mycobacterium tuberculosis gyrase inhibitors.
Tuberculosis
Transcription facilitated genome-wide recruitment of topoisomerase I and DNA gyrase.
Tuberculosis
Two interacting ATPases protect Mycobacterium tuberculosis from glycerol and nitric oxide toxicity.
Tuberculosis
Unravelling the pleiotropic role of the MceG ATPase in Mycobacterium smegmatis.
Tuberculosis
WQ-3810: A new fluoroquinolone with a high potential against fluoroquinolone-resistant Mycobacterium tuberculosis.
Tuberculosis
[Investigation of Mycobacterium tuberculosis sensitivity to fluoroquinolone, by revealing gyrA gene mutations]
Tuberculosis, Multidrug-Resistant
A novel inhibitor of gyrase B is a potent drug candidate for treatment of tuberculosis and nontuberculosis mycobacterial infections.
Tuberculosis, Multidrug-Resistant
Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.
Tuberculosis, Multidrug-Resistant
In silico study directed towards identification of the key structural features of GyrB inhibitors targeting MTB DNA gyrase: HQSAR, CoMSIA and molecular dynamics simulations.
Tuberculosis, Multidrug-Resistant
Optimization of pyrrolamides as mycobacterial GyrB ATPase inhibitors: structure-activity relationship and in vivo efficacy in a mouse model of tuberculosis.
Tuberculosis, Multidrug-Resistant
Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase.
Tuberculosis, Pulmonary
First-in-Human Evaluation of the Safety, Tolerability, and Pharmacokinetics of SPR720, a Novel Oral Bacterial DNA Gyrase (GyrB) Inhibitor for Mycobacterial Infections.
Typhoid Fever
Study of the role of efflux pump in ciprofloxacin resistance in Salmonella enterica serotype Typhi.
Typhoid Fever
[Ciprofloxacin in Salmonella infection and abdominal typhoid]
Unconsciousness
[Effect of repeated cerebral ischemia induced by lower body negative pressure on neuronal morphology and ions contents, ATPase activity of brain tissue in rats]
Uremia
Abnormal sodium transport in synaptosomes from brain of uremic rats.
Uremia
Alternate reasons for atherogenesis in uremia.
Uremia
An Na, K ATPase inhibitor from ultrafiltrate obtained by hemodialysis of patients with uremia.
Uremia
Effect of dialysis on circulating Na,K ATPase inhibitor in uremic patients.
Uremia
Inhibition of Na+,K+-stimulated ATPase in the cochlea of the guinea pig. A potential cause of disturbed inner ear function in terminal renal failure.
Uremia
Reversal of decreased phosphorylation of sarcoplasmic reticulum calcium transport ATPase by 1,25-dihydroxycholecalciferol in experimental uremia.
Uremia
Studies of subcellular control factors in hearts of uremic rats.
Uremia
[ATPase activity in brain tissue in acute experimental uremia]
Ureteral Obstruction
Changes of renal cortical Na-K ATPase activity, protein, and mRNA expression in ureteral obstruction.
Ureteral Obstruction
Enzyme activity in obstructive uropathy: basis for salt wastage and the acidification defect.
Urinary Bladder Neoplasms
?III-tubulin overexpression is linked to aggressive tumor features and genetic instability in urinary bladder cancer.
Urinary Bladder Neoplasms
Clinical Implications and Prognostic Values of Topoisomerase-II Alpha Expression in Primary Non-Muscle-Invasive Bladder Cancer.
Urinary Bladder Neoplasms
Expression of multidrug resistance-associated protein (MRP), MDR1 and DNA topoisomerase II in human multidrug-resistant bladder cancer cell lines.
Urinary Bladder Neoplasms
HER-2 and TOP2A coamplification in urinary bladder cancer.
Urinary Bladder Neoplasms
LASS2 inhibits growth and invasion of bladder cancer by regulating ATPase activity.
Urinary Bladder Neoplasms
MiR-599 targeting TOP2A inhibits the malignancy of bladder cancer cells.
Urinary Bladder Neoplasms
Mitochondrial DNA mutations in chemical carcinogen-induced rat bladder and human bladder cancer.
Urinary Bladder Neoplasms
Multifactorial involvement of multidrug resistance-associated [correction of resistance] protein, DNA topoisomerase II and glutathione/glutathione-S-transferase in nonP-glycoprotein-mediated multidrug resistance in human bladder cancer cells.
Urinary Bladder Neoplasms
Non-P-glycoprotein-mediated atypical multidrug resistance in a human bladder cancer cell line.
Urinary Bladder Neoplasms
OIP5 Promotes Growth, Metastasis and Chemoresistance to Cisplatin in Bladder Cancer Cells.
Urinary Bladder Neoplasms
Predictive value of topoisomerase II alpha immunostaining in urothelial bladder carcinoma.
Urinary Bladder Neoplasms
Quantitative microscopy of human DNA topoisomerase II-alpha expression in transitional cell carcinoma of the bladder.
Urinary Bladder Neoplasms
Relationship between topoisomerase II level and chemosensitivity in human tumor cell lines.
Urinary Bladder Neoplasms
Response to epirubicin in patients with superficial bladder cancer and expression of the topoisomerase II alpha and beta genes.
Urinary Bladder Neoplasms
Silencing of ATPase Inhibitory Factor 1 Inhibits Cell Growth via Cell Cycle Arrest in Bladder Cancer.
Urinary Bladder Neoplasms
Structural and functional analysis of the control region of the human DNA topoisomerase II alpha gene in drug-resistant cells.
Urinary Bladder Neoplasms
The role of an inverted CCAAT element in transcriptional activation of the human DNA topoisomerase IIalpha gene by heat shock.
Urinary Bladder Neoplasms
Tumor necrosis factor enhances the in vitro and in vivo efficacy of chemotherapeutic drugs targeted at DNA topoisomerase II in the treatment of murine bladder cancer.
Urinary Bladder Neoplasms
[HER-2 and TOP 2A gene amplifications in urinary bladder carcinoma]
Urinary Bladder Neoplasms
[HER-2 and TOP2A gene amplification in urinary bladder cancer]
Urinary Tract Infections
Biological cost of single and multiple norfloxacin resistance mutations in Escherichia coli implicated in urinary tract infections.
Urinary Tract Infections
Co-Incidence of Type II Topoisomerase Mutations and Efflux Expression in High Fluoroquinolone Resistant Enterococcus faecalis Isolated from Urinary Tract Infections.
Urinary Tract Infections
Comparison of minimum inhibitory concentration results for gepotidacin obtained using agar dilution and broth microdilution methods.
Urinary Tract Infections
Incomplete cross-resistance of nalidixic and pipemidic acid-resistant variants of Serratia marcescens against ciprofloxacin, enoxacin, and norfloxacin.
Urinary Tract Infections
Phase 2a Pharmacokinetic, Safety, and Exploratory Efficacy Evaluation of Oral Gepotidacin (GSK2140944) in Female Participants with Uncomplicated Urinary Tract Infection (Acute Uncomplicated Cystitis).
Urinary Tract Infections
The frequency of DNA gyrase and topoisomerase IV mutations, and plasmid-mediated quinolone resistance genes among Escherichia coli and Klebsiella pneumoniae isolated from urinary tract infections in Azerbaijan, Iran.
Urinary Tract Infections
[Ciprofloxacin and therapy of urinary tract infections, including those due to Staphylococcus saprophyticus]
Uterine Cervical Neoplasms
A peptide fraction from germinated soybean protein down-regulates PTTG1 and TOP2A mRNA expression, inducing apoptosis in cervical cancer cells.
Uterine Cervical Neoplasms
Bioinformatics analysis shows that TOP2A functions as a key candidate gene in the progression of cervical cancer.
Uterine Cervical Neoplasms
Effect of germinated soy protein on the growth of HeLa cervical cancer cells in female athymic mice.
Uterine Cervical Neoplasms
First evidence for the contribution of the genetic variations of BRCA1-interacting protein 1 (BRIP1) to the genetic susceptibility of cervical cancer.
Uterine Cervical Neoplasms
Human Papillomavirus E7 Oncoprotein Promotes Proliferation and Migration through the Transcription Factor E2F1 in Cervical Cancer Cells.
Uterine Cervical Neoplasms
Human papillomavirus infection and expression of ATPase family AAA domain containing 3A, a novel anti-autophagy factor, in uterine cervical cancer.
Uterine Cervical Neoplasms
Identification of key genes and pathways of diagnosis and prognosis in cervical cancer by bioinformatics analysis.
Uterine Cervical Neoplasms
Identification of key pathways and genes in the progression of cervical cancer using bioinformatics analysis.
Uterine Cervical Neoplasms
Immunocytochemical study of TOP2A and Ki-67 in cervical smears from women under routine gynecological care.
Uterine Cervical Neoplasms
Integrated analysis reveals down-regulation of SPARCL1 is correlated with cervical cancer development and progression.
Uterine Cervical Neoplasms
Over-Expression of Topoisomerase IIalpha is Related to the Grade of Cervical Intraepithelial Neoplasia (CIN) and High-Risk Human Papillomavirus (HPV), but does not Predict Prognosis in Cervical Cancer or HPV Clearance after Cone Treatment.
Uterine Cervical Neoplasms
Prognostic significance of topoisomerase II alpha and collagen IV immunoexpression in cervical cancer.
Uterine Cervical Neoplasms
The SUMO-targeted ubiquitin ligase RNF4 localizes to etoposide-exposed mitotic chromosomes: Implication for a novel DNA damage response during mitosis.
Uterine Cervical Neoplasms
TOP2A and CENPF are synergistic master regulators activated in cervical cancer.
Uterine Cervical Neoplasms
TOP2A Promotes Cell Migration, Invasion and Epithelial-Mesenchymal Transition in Cervical Cancer via Activating the PI3K/AKT Signaling.
Uterine Cervical Neoplasms
Viral and cellular biomarkers in the diagnosis of cervical intraepithelial neoplasia and cancer.
Uterine Cervical Neoplasms
[Histochemical study of ATPase in cervix cancer]
Uterine Inertia
[ATPase activity and fluorescence of myometrial actomyosin in experimental uterine inertia]
Uterine Neoplasms
Paclitaxel inhibits expression of heat shock protein 27 in ovarian and uterine cancer cells.
Vaccinia
A role for ATP hydrolysis in vaccinia virus early gene transcription. Dissociation of the early transcription factor-promoter complex.
Vaccinia
A yeast-based genetic system for functional analysis of viral mRNA capping enzymes.
Vaccinia
An ATPase component of the transcription elongation complex is required for factor-dependent transcription termination by vaccinia RNA polymerase.
Vaccinia
Biochemical and genetic analysis of the vaccinia virus d5 protein: Multimerization-dependent ATPase activity is required to support viral DNA replication.
Vaccinia
Characterization of the vaccinia virus RNA 5'-triphosphatase and nucleotide triphosphate phosphohydrolase activities. Demonstrate that both activities are carried out at the same active site.
Vaccinia
Cloning of an SNF2/SWI2-related protein that binds specifically to the SPH motifs of the SV40 enhancer and to the HIV-1 promoter.
Vaccinia
DNA-dependent ATPase activity associated with vaccinia virus early transcription factor.
Vaccinia
Fluoroquinolone-dependent DNA supercoiling by Vaccinia topoisomerase I.
Vaccinia
Gene A32 product of vaccinia virus may be an ATPase involved in viral DNA packaging as indicated by sequence comparisons with other putative viral ATPases.
Vaccinia
Genetic evidence for involvement of vaccinia virus DNA-dependent ATPase I in intermediate and late gene expression.
Vaccinia
Goatpoxvirus ATPase activity is increased by dsDNA and decreased by zinc ion.
Vaccinia
Identification of the point mutations in two vaccinia virus nucleoside triphosphate phosphohydrolase I temperature-sensitive mutants and role of this DNA-dependent ATPase enzyme in virus gene expression.
Vaccinia
Identification of the vaccinia virus gene encoding nucleoside triphosphate phosphohydrolase I, a DNA-dependent ATPase.
Vaccinia
Interaction of the vaccinia virus nucleoside triphosphate phosphohydrolase I with linear oligonucleotides.
Vaccinia
Mechanism of inhibition of vaccinia DNA topoisomerase by novobiocin and coumermycin.
Vaccinia
Molecular chaperone Hsp90 is important for vaccinia virus growth in cells.
Vaccinia
Mutational analysis of vaccinia virus nucleoside triphosphate phosphohydrolase I, a DNA-dependent ATPase of the DExH box family.
Vaccinia
On the simultaneous binding of eukaryotic DNA topoisomerase II to a pair of double-stranded DNA helices.
Vaccinia
Proteins encoded by the bovine papillomavirus E1 open reading frame: expression in heterologous systems and in virally transformed cells.
Vaccinia
Purification and characterization of a DNA-dependent ATPase from Escherichia coli.
Vaccinia
Reduced DNA ligase activity in etoposide resistant human lymphatic leukaemia CEM cells.
Vaccinia
Shope fibroma virus. II. Role of the virion-associated nucleases.
Vaccinia
The DNA-dependent ATPase activity of vaccinia virus early gene transcription factor is essential for its transcription activation function.
Vaccinia
The vaccinia virus A18R gene product is a DNA-dependent ATPase.
Vaccinia
UUUUUNU oligonucleotide stimulation of vaccinia virus early gene transcription termination, in trans.
Vaccinia
Vaccinia NPH-I, a DExH-box ATPase, is the energy coupling factor for mRNA transcription termination.
Vaccinia
Vaccinia virion protein I8R has both DNA and RNA helicase activities: implications for vaccinia virus transcription.
Vaccinia
Vaccinia virus DNA ligase recruits cellular topoisomerase II to sites of viral replication and assembly.
Vaccinia
Vaccinia virus early gene transcription termination factors VTF and Rap94 interact with the U9 termination motif in the nascent RNA in a transcription ternary complex.
Vaccinia
Vaccinia virus gene A18R encodes an essential DNA helicase.
Vaccinia
Vaccinia virus nucleoside triphosphate phosphohydrolase I controls early and late gene expression by regulating the rate of transcription.
Vaccinia
Vaccinia virus nucleoside triphosphate phosphohydrolase I is an essential viral early gene transcription termination factor.
Vascular Calcification
Erythrocyte Membrane Bound ATPase and Antioxidant Enzyme Changes Associated with Vascular Calcification is Reduced by Sodium Thiosulfate.
Vascular Calcification
Inhibition of Phosphate-Induced Vascular Smooth Muscle Cell Osteo-/Chondrogenic Signaling and Calcification by Bafilomycin A1 and Methylamine.
Vascular Calcification
Inhibition of Vascular Calcification.
Vascular Calcification
Teniposide regulates the phenotype switching of vascular smooth muscle cells in a miR-21-dependent manner.
Vasculitis, Central Nervous System
Digoxin : a model for hypothalamic regulation of neuronal transmission, endocrine function, immunity and cytodifferentiation.
Ventricular Dysfunction
Human myocardial adenosine triphosphatase activities in health and heart failure.
Ventricular Fibrillation
Myocardial ischaemic/reperfusion injury in the anaesthetized rabbit: comparative effects of halothane and isoflurane.
Ventricular Fibrillation
[Prevention of experimental ventricular fibrillation by Na K ATPase activation]
Vesicular Stomatitis
A non-canonical role of the p97 complex in RIG-I antiviral signaling.
Vesicular Stomatitis
Concanamycin A: a powerful inhibitor of enveloped animal-virus entry into cells.
Viremia
Host competence and helicase activity differences exhibited by West Nile viral variants expressing NS3-249 amino acid polymorphisms.
Virus Diseases
1,3-Dihydroxyacridone derivatives as inhibitors of herpes virus replication.
Virus Diseases
Activation of the human thymidine kinase (TK) promoter by simian virus 40 large T antigen requires both the T antigen pRb family-binding domain and TK promoter sequences resembling E2F-binding sites.
Virus Diseases
Alterations in monovalent cation transport in Sindbis virus-infected chick cells.
Virus Diseases
Coxsackie B1 virus-induced changes in cell membrane-associated functions are not responsible for altered sensitivity to bacterial invasiveness.
Virus Diseases
Helicase ATPase activity of the Tobacco mosaic virus 126-kDa protein modulates replicase complex assembly.
Virus Diseases
Inhibition of topoisomerase IIA (Top2?) induces telomeric DNA damage and T cell dysfunction during chronic viral infection.
Virus Diseases
Koala and wombat gammaherpesviruses encode the first known viral nucleoside triphosphate diphosphohydrolase (NTPDase) homologs and are phylogenetically divergent from all known gammaherpesviruses.
Virus Diseases
Sarco/Endoplasmic Reticulum Ca2+ Transporting ATPase (SERCA) Modulates Autophagic, Inflammatory, and Mitochondrial Responses during Influenza A Virus Infection in Human Lung Cells.
Virus Diseases
Synthesis and evaluation of acridine- and acridone-based anti-herpes agents with topoisomerase activity.
Virus Diseases
The origin-binding domain of the herpes simplex virus type 1 UL9 protein is not required for DNA helicase activity.
Virus Diseases
The Peptide-Binding and ATPase Domains of Recombinant hsc70 Are Required To Interact with Rotavirus and Reduce Its Infectivity.
Virus Diseases
Topoisomerase II from Chlorella virus PBCV-1 has an exceptionally high DNA cleavage activity.
Virus Diseases
TopoisomeraseII? in HIV-1 transactivation.
Virus Diseases
[Characteristics of lipid composition, lipid peroxidation intensity and ATPase activity of lymphocytes in children with acute respiratory viral infections]
Vision Disorders
Reduction of the ATPase inhibitory factor 1 (IF1) leads to visual impairment in vertebrates.
Vitamin A Deficiency
[Effect of vitamin A deficiency on ATPase activity and the transport functions of erythrocyte membranes]
Vitamin A Deficiency
[Permeability of cell membranes of small intestine mucosa and their ATPase activity during vitamin A deficiency and irradiation]
Vitamin E Deficiency
[Fractional composition and activity of ATPase proteins in the aorta of rats with vitamin E deficiency]
Vitiligo
Hydrogen peroxide-mediated oxidative stress disrupts calcium binding on calmodulin: more evidence for oxidative stress in vitiligo.
Vitreoretinopathy, Proliferative
Effects of topoisomerase II inhibitors on retinal pigment epithelium and experimental proliferative vitreoretinopathy.
von Hippel-Lindau Disease
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
von Hippel-Lindau Disease
von Hippel-Lindau syndrome: cloning and identification of the plasma membrane Ca(++)-transporting ATPase isoform 2 gene that resides in the von Hippel-Lindau gene region.
Waldenstrom Macroglobulinemia
2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy]-propionic acid (XK469) inhibition of topoisomerase IIbeta is not sufficient for therapeutic response in human Waldenstrom's macroglobulinemia xenograft model.
Waldenstrom Macroglobulinemia
2-[4-(7-chloro-2-quinoxalinyloxyphenoxy]-propionic acid (XK469), an inhibitor of topoisomerase (Topo) IIbeta, up-regulates Topo IIalpha and enhances Topo IIalpha-mediated cytotoxicity.
Waldenstrom Macroglobulinemia
XK469, a topo IIbeta inhibitor, induces apoptosis in Waldenstrom's macroglobulinemia through multiple pathways.
Wasting Syndrome
Erythrocyte sodium transport in Bartter's syndrome.
Water Intoxication
Sex-dependent changes in blood-brain barrier permeability and brain NA(+),K(+) ATPase activity in rats following acute water intoxication.
Werner Syndrome
Catalytic inhibition of topoisomerase II in Werner's syndrome cell lines enhances chromosomal damage induced by X-rays in the G2 phase of the cell cycle.
Werner Syndrome
Length-dependent degradation of single-stranded 3' ends by the Werner syndrome protein (WRN): implications for spatial orientation and coordinated 3' to 5' movement of its ATPase/helicase and exonuclease domains.
Werner Syndrome
Werner's syndrome lymphoblastoid cells are hypersensitive to topoisomerase II inhibitors in the G2 phase of the cell cycle.
Whooping Cough
D2-like receptor-mediated inhibition of Na+-K+-ATPase activity is dependent on the opening of K+ channels.
Whooping Cough
Effect of adenosine on the ouabain-insensitive Na+-ATPase activity from basolateral membrane of the proximal tubule.
Whooping Cough
Immunochemical localization of a region of chaperonin-60 important for productive interaction with chaperonin-10.
Whooping Cough
Localization of the binding site of an antibody affecting ATPase activity of chaperonin cpn60 from Bordetella pertussis.
Whooping Cough
Requirements for assembly of PtlH with the pertussis toxin transporter apparatus of Bordetella pertussis.
Whooping Cough
Synthetic peptides based on the calmodulin-binding domain of myosin light chain kinase inhibit activation of other calmodulin-dependent enzymes.
Williams Syndrome
Chromatin remodeling by WSTF-ISWI at the replication site: opening a window of opportunity for epigenetic inheritance?
Wilms Tumor
Differential expression of the drug resistance markers DNA topoisomerase II alpha and glutathione S-transferase-pi in the histological compartments of Wilms' tumors.
Wilms Tumor
Expression of multidrug resistance-related protein (mrp-1), lung resistance-related protein (lrp) and topoisomerase-ii (topo-ii) in wilms' tumor: immunohistochemical study using tma methodology.
Wilms Tumor
Topoisomerase IIalpha in Wilms' tumour: gene alterations and immunoexpression.
Xeroderma Pigmentosum
Alteration of a DNA-dependent ATPase activity in xeroderma pigmentosum complementation group C cells.
Xeroderma Pigmentosum
Cellular consequences of overproduction of DNA topoisomerase II in an ataxia-telangiectasia cell line.
Xeroderma Pigmentosum
Characterization of the properties of a human homologue of Escherichia coli RecQ from xeroderma pigmentosum group C and from HeLa cells.
Xeroderma Pigmentosum
Doxorubicin and gamma rays increase the level of DNA topoisomerase IIalpha in nuclei of normal and xeroderma pigmentosum fibroblasts.
Xeroderma Pigmentosum
Irradiation with ultraviolet light and gamma-rays increases the level of DNA topoisomerase II in nuclei of normal and xeroderma pigmentosum fibroblasts.
Xeroderma Pigmentosum
Purification of two DNA-dependent adenosinetriphosphatases having DNA helicase activity from HeLa cells and comparison of the properties of the two enzymes.
Xeroderma Pigmentosum
The effects of inhibitors of topoisomerase II and quinacrine on ultraviolet-light-induced DNA incision in normal and xeroderma pigmentosum fibroblasts.
Zollinger-Ellison Syndrome
Pharmacological management of patients with peptic ulcer disease: prospects for the late 1980's.
Zollinger-Ellison Syndrome
[A case of Zollinger-Ellison syndrome successfully treated with an H+-K+ ATPase inhibitor]
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5.6.2.2 DNA topoisomerase (ATP-hydrolysing)
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
