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Disease on EC 5.6.1.8 - myosin ATPase

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DISEASE
TITLE OF PUBLICATION
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Acidosis
Acidosis affects muscle contraction by slowing the rates myosin attaches to and detaches from actin.
Acidosis decreases the Ca2+ sensitivity of thin filaments by preventing the first actomyosin interaction.
Acidosis has no effect on the ATP cost of contraction in cat fast- and slow-twitch skeletal muscles.
Acidosis modifies effects of phosphorylated tropomyosin on the actin-myosin interaction in the myocardium.
Acute myopathy with selective degeneration of myosin filaments following status asthmaticus treated with methylprednisolone and vecuronium.
Acute myopathy with selective lysis of myosin filaments.
Ca++-sensitizing mutations in troponin, Pi and 2-deoxyATP alter the depressive effect of acidosis on regulated thin filament velocity.
The effects of phosphate and acidosis on regulated thin-filament velocity in an in vitro motility assay.
Acquired Immunodeficiency Syndrome
A node organization in the actomyosin contractile ring generates tension and aids stability.
A series of related nucleotide analogues that aids optimization of fluorescence signals in probing the mechanism of P-loop ATPases, such as actomyosin.
Amino acids 519-524 of Dictyostelium myosin II form a surface loop that aids actin binding by facilitating a conformational change.
Detection of natural autoantibodies in the serum of anti-HIV-positive individuals.
Myosin subfragment binding for the localization of actin-like microfilaments in cultured cells. A light and electron microscope study.
Response to Zambon et al.
The myosin co-chaperone UNC-45 is required for skeletal and cardiac muscle function in zebrafish.
Acute Coronary Syndrome
Cardiac involvement in malignant syndrome in Parkinson's disease.
Cardiac Myosin Binding Protein-C Autoantibodies are Potential Early Indicators of Cardiac Dysfunction and Patient Outcome in Acute Coronary Syndrome.
Creatine kinase isoenzyme MB mass, cardiac troponin T, and myosin light chain isotype 1 as serological markers of myocardial injury and their prognostic importance in acute coronary syndrome.
Prevalence of autoantibodies against contractile proteins in coronary artery disease and their clinical implications.
Acute Lung Injury
A self-organized actomyosin drives multiple intercellular junction disruption and directly promotes neutrophil recruitment in lipopolysaccharide-induced acute lung injury.
Endothelial cell-secreted MIF reduces pericyte contractility and enhances neutrophil extravasation.
miR-144-mediated Inhibition of ROCK1 Protects against LPS-induced Lung Endothelial Hyperpermeability.
Non-muscle myosin II knockdown improves survival and therapeutic effects of implanted bone marrow-derived mesenchymal stem cells in lipopolysaccharide-induced acute lung injury.
RhoA and Rho-kinase dependent and independent signals mediate TGF-beta-induced pulmonary endothelial cytoskeletal reorganization and permeability.
The HSP90 Inhibitor, AUY-922, Protects and Repairs Human Lung Microvascular Endothelial Cells from Hydrochloric Acid-Induced Endothelial Barrier Dysfunction.
Adenocarcinoma
Characterizing optical coherence tomography speckle fluctuation spectra of mammary organoids during suppression of intracellular motility.
Comparison of the efficiency of transgelin, smooth muscle myosin, and CD31 antibodies for the assessment of vascular tumor invasion and free tumor deposits in gastric, pancreatic, and colorectal adenocarcinomas.
Cytoplasmic actomyosin fibrils in tissue culture cells: direct proof of contractility by visualization of ATP-induced contraction in fibrils isolated by laser micro-beam dissection.
Dependence of metastatic cancer cell invasion on MLCK-catalyzed phosphorylation of myosin regulatory light chain.
Hierarchical cluster analysis of myoepithelial/basal cell markers in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma.
Identification of myosin in human epithelial cancers with immunofluorescence.
Inhibition of pancreatic adenocarcinoma cellular invasiveness by blebbistatin: a novel myosin II inhibitor.
Intermediate-sized filaments and specific markers in a human salivary gland adenocarcinoma cell line and its nude mouse tumors.
MYL6B drives the capabilities of proliferation, invasion, and migration in rectal adenocarcinoma through the EMT process.
Myofibroblasts are responsible for the desmoplastic reaction surrounding human pancreatic carcinomas.
Non-muscle myosin heavy chain as a possible target for protein encoded by metastasis-related mts-1 gene.
Proteomic analysis of stage I primary lung adenocarcinoma aimed at individualisation of postoperative therapy.
Adenocarcinoma of Lung
Expression of ERCC1, TYMS, RRM1, TUBB3, non-muscle myosin II, myoglobin and MyoD1 in lung adenocarcinoma pleural effusions predicts survival in patients receiving platinum-based chemotherapy.
Irradiation-tolerant lung cancer cells acquire invasive ability dependent on dephosphorylation of the myosin regulatory light chain.
MYBPH inhibits NM IIA assembly via direct interaction with NMHC IIA and reduces cell motility.
MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis.
Adenolymphoma
[Salivary gland adenolymphomas as seen in current histochemical and immunomorphological research]
Adenoma
Immunohistochemical study of myofibroblasts in normal colonic mucosa, hyperplastic polyps, and adenomatous colorectal polyps.
Myoepitheliomas and myoepithelial adenomas of salivary gland origin. Immunohistochemical evaluation of filament proteins, S-100 alpha and beta, glial fibrillary acidic proteins, neuron-specific enolase, and lactoferrin.
Non-muscle myosin heavy chain 9 maintains intestinal homeostasis by preventing epithelium necroptosis and colitis adenoma formation.
Normal and neoplastic myoepithelial cells in salivary glands: an immunohistochemical study.
Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome.
Adenoma, Islet Cell
Myofibroblasts are responsible for the desmoplastic reaction surrounding human pancreatic carcinomas.
Adenoma, Pleomorphic
Immunolocalization of three novel smooth muscle-specific proteins in salivary gland pleomorphic adenoma: assessment of the morphogenetic role of myoepithelium.
Normal and neoplastic myoepithelial cells in salivary glands: an immunohistochemical study.
Search for specific markers of neoplastic epithelial duct and myoepithelial cell lines established from human salivary gland and characterization of their growth in vitro.
The myoepithelial immunophenotype in 135 benign and malignant salivary gland tumors other than pleomorphic adenoma.
[An immunoelectron microscopic study of the myoepithelial cells in salivary gland pleomorphic adenoma]
[Histogenesis of pleomorphic adenomas of the salivary glands]
Adenomyosis
Phenotypic characterization of adenomyosis occurring at the inner and outer myometrium.
Adenoviridae Infections
Nuclear actin and myosins in adenovirus infection.
Up-regulation of Rhoa/Rho kinase pathway by translationally controlled tumor protein in vascular smooth muscle cells.
AIDS-Related Complex
Detection of natural autoantibodies in the serum of anti-HIV-positive individuals.
Albinism
Abnormally Small Neuromuscular Junctions in the Extraocular Muscles From Subjects With Idiopathic Nystagmus and Nystagmus Associated With Albinism.
Albinism, Oculocutaneous
Interactions between SNP alleles at multiple loci contribute to skin color differences between caucasoid and mongoloid subjects.
Albuminuria
Polymorphisms in the Nonmuscle Myosin Heavy Chain 9 Gene (MYH9) Are Associated with Albuminuria in Hypertensive African Americans: The HyperGEN Study.
Altitude Sickness
Effect of intermittent high altitude hypoxia on the structure and enzymatic activity of cardiac myosin.
Alzheimer Disease
Amyloid ? peptide stimulates platelet activation through RhoA-dependent modulation of actomyosin organization.
Filamin-A and Myosin VI colocalize with fibrillary Tau protein in Alzheimer's disease and FTDP-17 brains.
Amyloidosis
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Amyotrophic Lateral Sclerosis
Absolute quantification of myosin heavy chain isoforms by selected reaction monitoring can underscore skeletal muscle changes in a mouse model of amyotrophic lateral sclerosis.
Defects in optineurin- and myosin VI-mediated cellular trafficking in amyotrophic lateral sclerosis.
Human extraocular muscles in ALS.
Impact of Amyotrophic Lateral Sclerosis on Slow Tonic Myofiber Composition in Human Extraocular Muscles.
Increased expression of Myosin binding protein H in the skeletal muscle of amyotrophic lateral sclerosis patients.
Myogenesis in human denervated muscle biopsies.
VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.
Anemia
Mild Maternal Iron Deficiency Anemia Induces Hearing Impairment Associated with Reduction of Ribbon Synapse Density and Dysregulation of VGLUT3, Myosin VIIa, and Prestin Expression in Young Guinea Pigs.
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Anemia, Iron-Deficiency
Mild Maternal Iron Deficiency Anemia Induces Hearing Impairment Associated with Reduction of Ribbon Synapse Density and Dysregulation of VGLUT3, Myosin VIIa, and Prestin Expression in Young Guinea Pigs.
Aneurysm
A longitudinal immunohistochemical study of the healing of experimental aneurysms after embolization with platinum coils.
Augmented expression of atrial myosin light chain 1 in ventricular aneurysms of human: enzyme immunoassay for atrial myosin light chain 1.
Congenital ductus arteriosus aneurysm in association with MYH11 mutation: a case report.
Enhanced embryonic nonmuscle myosin heavy chain isoform and matrix metalloproteinase expression in aortic abdominal aneurysm with rapid progression.
The Effect of Myosin Light Chain Kinase on the Occurrence and Development of Intracranial Aneurysm.
Aneurysm, Dissecting
A deletion mutation in myosin heavy chain 11 causing familial thoracic aortic dissection in two Japanese pedigrees.
Biochemical diagnosis of aortic dissection: from bench to bedside.
Biomarker-assisted diagnosis of acute aortic dissection: how far we have come and what to expect.
Diagnosis of aortic dissection by immunoassay for circulating smooth muscle myosin.
Diagnostic implications of elevated levels of smooth-muscle myosin heavy-chain protein in acute aortic dissection. The smooth muscle myosin heavy chain study.
Immunoscintigraphy of aortic dissection with 99mTc-labeled murine anti-smooth muscle myosin monoclonal antibody in rats.
Novel biochemical diagnostic method for aortic dissection. Results of a prospective study using an immunoassay of smooth muscle myosin heavy chain.
Pathophysiology, diagnosis, and management of aortic dissection.
[Aortic dissection]
[Increased serum concentration of myosin heavy chain in aortic dissection: discussion of 2 cases]
[Radioimmunoimaging of aortic dissection and acute bowel infarction with radiolabeled [correction of radioiodinated] murine antismooth muscle myosin antibody.
Angina Pectoris
Increase in serum cardiac myosin light chain I associated with elective percutaneous transluminal coronary angioplasty in patients with ischemic heart disease.
Myoglobin, creatine kinase-B isoenzyme, and myosin light chain release in patients with unstable angina pectoris.
[The effect of myosin from the human myocardium on quantitative T-lymphocyte values--active rosettes in patients with myocardial infarct and stenocardia]
Angina, Unstable
Circulating cardiac myosin light chains in patients with angina at rest: identification of a high risk subgroup.
Immunoscintigraphy for detecting acute myocardial infarction without electrocardiographic changes.
Level of ventricular myosin light chains 1 and 2 determined by ELISA in serum of patients with acute myocardial infarction.
Myoglobin, creatine kinase-B isoenzyme, and myosin light chain release in patients with unstable angina pectoris.
Prognostic significance of the number of leads with ST depression during an anginal attack in high risk patients with unstable angina.
[The determination of myocardial necrosis in unstable angina by the immunoradiometric measurement of circulating myosin]
Angiomyoma
Smooth and skeletal muscle myosins in spindle cell tumors of soft tissue. An immunohistochemical study.
Aortic Aneurysm
Characterization of aortic aneurysms in cardiovascular disease patients harboring Porphyromonas gingivalis.
Lenvatinib halts aortic aneurysm growth by restoring smooth muscle cell contractility.
LncRNA Sox2ot modulates the progression of thoracic aortic aneurysm by regulating miR-330-5p/Myh11.
Aortic Aneurysm, Abdominal
Proteomic analysis of aortic smooth muscle cell secretions reveals an association of myosin heavy chain 11 with abdominal aortic aneurysm.
Aortic Aneurysm, Thoracic
A deleterious MYH11 mutation causing familial thoracic aortic dissection.
An HDAC9-MALAT1-BRG1 complex mediates smooth muscle dysfunction in thoracic aortic aneurysm.
Rare, nonsynonymous variant in the smooth muscle-specific isoform of myosin heavy chain, MYH11, R247C, alters force generation in the aorta and phenotype of smooth muscle cells.
Aortic Coarctation
Humoral factor(s) produced by pressure overload enhance cardiac hypertrophy and natriuretic peptide expression.
Propranolol causes a paradoxical enhancement of cardiomyocyte foetal gene response to hypertrophic stimuli.
Aortic Diseases
Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and Dissections.
Genetic approaches to identify pathological limitations in aortic smooth muscle contraction.
[Increased serum concentration of myosin heavy chain in aortic dissection: discussion of 2 cases]
Aortic Valve Disease
Cardiac catheterization and other imaging modalities in the evaluation of valvular heart disease.
Hemodynamic performance and myosin light chain-1 expression of the hypertrophied left ventricle in aortic valve disease before and after valve replacement.
Aortic Valve Insufficiency
Effects of the cardiac myosin activator Omecamtiv-mecarbil on severe chronic aortic regurgitation in Wistar rats.
Myofibrillar protein turnover in cardiac hypertrophy due to aortic regurgitation.
Myosin isoenzyme changes in several models of rat cardiac hypertrophy.
Relationship between myosin isoenzyme composition, hemodynamics, and myocardial structure in various forms of human cardiac hypertrophy.
The myosin activator omecamtiv mecarbil improves wall stress in a rat model of chronic aortic regurgitation.
Aortic Valve Stenosis
Changes in LV papillary muscle performance and myosin composition with aortic insufficiency in rats.
Contractile function, myosin ATPase activity and isozymes in the hypertrophied pig left ventricle after a chronic progressive pressure overload.
Differential responses of canine myosin ATPase activity and tissue gases in the pressure-overloaded ventricle dependent upon degree of obstruction: mild versus severe pulmonic and aortic stenosis.
Dissociation of left ventricular hypertrophy, beta-myosin heavy chain gene expression, and myosin isoform switch in rats after ascending aortic stenosis.
Distinct Expression of Nonmuscle Myosin IIB in Pulmonary Arteries of Patients With Aortic Stenosis vs Insufficiency Undergoing a Ross Procedure.
Heart failure-associated changes in RNA splicing of sarcomere genes.
Implications of myocardial transformation for cardiac energetics.
Myocardial gene expression of microRNA-133a and myosin heavy and light chains, in conjunction with clinical parameters, predict regression of left ventricular hypertrophy after valve replacement in patients with aortic stenosis.
Myosin heavy chain expression and atrophy in rat skeletal muscle during transition from cardiac hypertrophy to heart failure.
Myosin isoenzyme changes in several models of rat cardiac hypertrophy.
Physiological adaptation of the heart to pathological overloading.
Pressure Overload Is Associated With Low Levels of Troponin I and Myosin Binding Protein C Phosphorylation in the Hearts of Patients With Aortic Stenosis.
[Total and contractile protein synthesis during experimental cardiac hypertrophy]
Appendicitis
Preoperative use of platelets in a 6-year-old with acute appendicitis and a myosin heavy chain 9-related disorder: a case report and review of literature.
Arrhythmias, Cardiac
A Novel Alpha Cardiac Actin (ACTC1) Mutation Mapping to a Domain in Close Contact with Myosin Heavy Chain Leads to a Variety of Congenital Heart Defects, Arrhythmia and Possibly Midline Defects.
Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector.
Subarachnoid hemorrhage and myocardial damage clinical and experimental studies.
The Transcription Factor ETV1 Induces Atrial Remodeling and Arrhythmia.
Arterial Occlusive Diseases
Expression of myosin heavy chain isoforms in skeletal muscle of patients with peripheral arterial occlusive disease.
Arteriosclerosis
cDNA cloning of a myosin heavy chain isoform in embryonic smooth muscle and its expression during vascular development and in arteriosclerosis.
Glabridin attenuates endothelial dysfunction and permeability, possibly via the MLCK/p-MLC signaling pathway.
Melatonin Attenuates Aortic Endothelial Permeability and Arteriosclerosis in Streptozotocin-Induced Diabetic Rats: Possible Role of MLCK- and MLCP-Dependent MLC Phosphorylation.
Phenotypic modulation of neointimal smooth muscle cells during the evolution of transplant renal arteriosclerosis determined via myosin heavy chain expression.
Arthralgia
Crocin Attenuates Joint Pain and Muscle Dysfunction in Osteoarthritis Rat.
Arthritis, Rheumatoid
Autoantibodies against cytoskeletal proteins in rheumatoid arthritis.
Counter-regulation of regulatory T cells by autoreactive CD8+ T cells in rheumatoid arthritis.
Myosin autoantibodies reacting with selective muscle fiber types.
Myosin IXB gene region and gluten intolerance: linkage to coeliac disease and a putative dermatitis herpetiformis association.
S100A4 regulates the Src-tyrosine kinase dependent differentiation of Th17 cells in rheumatoid arthritis.
The characteristics of antibodies of mice immunized by human unconventional myosin 1c.
Arthrogryposis
A novel TNNI2 mutation causes Freeman-Sheldon syndrome in a Chinese family with an affected adult with only facial contractures.
Correction: Two novel mutations in myosin binding protein C slow causing distal arthrogryposis type 2 in two large Han Chinese families may suggest important functional role of immunoglobulin domain C2.
Drosophila myosin mutants model the disparate severity of type 1 and type 2B distal arthrogryposis and indicate an enhanced actin affinity mechanism.
Embryonic myosin heavy-chain mutations cause distal arthrogryposis and developmental myosin myopathy that persists postnatally.
Evaluation of embryonic and perinatal myosin gene mutations and the etiology of congenital idiopathic clubfoot.
Hereditary myosin myopathies.
Heterozygous variants in MYBPC1 are associated with an expanded neuromuscular phenotype beyond arthrogryposis.
Loss of actomyosin regulation in distal arthrogryposis myopathy due to mutant myosin binding protein-C slow.
Mutations in embryonic myosin heavy chain (MYH3) cause Freeman-Sheldon syndrome and Sheldon-Hall syndrome.
Myosin binding protein C1: a novel gene for autosomal dominant distal arthrogryposis type 1.
Myosin Binding Protein-C Slow Phosphorylation is Altered in Duchenne Dystrophy and Arthrogryposis Myopathy in Fast-Twitch Skeletal Muscles.
Novel deletion of lysine 7 expands the clinical, histopathological and genetic spectrum of TPM2-related myopathies.
The embryonic myosin R672C mutation that underlies Freeman-Sheldon syndrome impairs crossbridge detachment and cycling in adult muscle.
Two novel mutations in Myosin binding protein C slow causing distal arthrogryposis type 2 in two large han chinese families may suggest important functional role of immunoglobulin domain c2.
Asthma
A nonmuscle myosin light chain kinase-dependent gene signature in peripheral blood mononuclear cells is linked to human asthma severity and exacerbation status.
Airway smooth muscle in asthma. Perturbed equilibria of myosin binding.
Anticholinergic agents in asthma: chronic bronchodilator therapy, relief of acute severe asthma, reduction of chronic viral inflammation and prevention of airway remodeling.
Association Study of Myosin Heavy Chain 15 Polymorphisms with Asthma Susceptibility in Chinese Han.
Biophysical basis for airway hyperresponsiveness.
Circulating MicroRNAs: Association with Lung Function in Asthma.
Disrupting actin-myosin-actin connectivity in airway smooth muscle as a treatment for asthma?
Filament evanescence of myosin II and smooth muscle function.
Intrapulmonary airway smooth muscle is hyperreactive with a distinct proteome in asthma.
Myosin, transgelin, and myosin light chain kinase: expression and function in asthma.
ZIP kinase, a key regulator of myosin protein phosphatase 1.
Astrocytoma
Role of myosin II activity and the regulation of myosin light chain phosphorylation in astrocytomas.
Atherosclerosis
2-amino-phenoxazine-3-one attenuates glucose-induced augmentation of embryonic form of myosin heavy chain, endothelin-1 and plasminogen activator inhibitor-1 in human umbilical vein endothelial cells.
A nifedipine-sensitive smooth muscle cell population is present in the atherosclerotic rabbit aorta.
Computational pharmacology and bioinformatics to explore the potential mechanism of Schisandra against atherosclerosis.
Differentially expressed soluble proteins in aortic cells from atherosclerosis-susceptible and resistant pigeons.
Further evaluation of immunocytochemical staining in the diagnosis of early myocardial ischaemic/hypoxic damage.
Glabridin attenuates endothelial dysfunction and permeability, possibly via the MLCK/p-MLC signaling pathway.
Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis.
Immunohistochemical analysis of target proteins of Rho-kinase in a mouse model of accelerated atherosclerosis.
Impact of nifedipine on vascular smooth muscle cell differentiation. Implications for atherogenesis.
Importance of NAD(P)H oxidase-mediated oxidative stress and contractile type smooth muscle myosin heavy chain SM2 at the early stage of atherosclerosis.
Increased Plasma Levels of Myosin Heavy Chain 11 Is Associated with Atherosclerosis.
Intracellular signaling by 8-epi-prostaglandin F2 alpha is mediated by thromboxane A2/prostaglandin endoperoxide receptors in porcine carotid arteries.
Myosin isoform expression and smooth muscle cell heterogeneity in normal and atherosclerotic rabbit aorta.
Neutralization of S100A4 induces stabilization of atherosclerotic plaques: role of smooth muscle cells.
Phenotypic modulation of smooth muscle cells during progression of human atherosclerosis as determined by altered expression of myosin heavy chain isoforms.
Prolonged inhibition of nitric oxide synthesis in Yoshida hyperlipidemic rat: aorta functional and structural properties.
Structure and characterization of the 5'-flanking region of the mouse smooth muscle myosin heavy chain (SM1/2) gene.
Substrates of Factor XIII-A: roles in thrombosis and wound healing.
Tropomyosin 4 expression is enhanced in dedifferentiating smooth muscle cells in vitro and during atherogenesis.
[Relationship between the concentration of antibodies to myosin heavy chains in serum and symptomatic carotid atherosclerosis]
Atrial Fibrillation
A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation.
Antibodies against myosin in sera of patients with idiopathic paroxysmal atrial fibrillation.
Association of the MYH6 Gene Polymorphism with the Risk of Atrial Fibrillation and Warfarin Anticoagulation Therapy.
Familial hypertrophic cardiomyopathy and atrial fibrillation caused by Arg663His beta-cardiac myosin heavy chain mutation.
Functional genomic study on atrial fibrillation using cDNA microarray and two-dimensional protein electrophoresis techniques and identification of the myosin regulatory light chain isoform reprogramming in atrial fibrillation.
Long-term outcome of 4 Korean families with hypertrophic cardiomyopathy caused by 4 different mutations.
Reprogramming of the human atrial transcriptome in permanent atrial fibrillation: expression of a ventricular-like genomic signature.
Rs4968309 in Myosin Light Chain 4 (MYL4) Associated With Atrial Fibrillation Onset and Predicts Clinical Outcomes After Catheter Ablation in Atrial Fibrillation Patients Without Structural Heart Disease.
Autoimmune Diseases
A missense mutation in MYH1 is associated with susceptibility to immune-mediated myositis in Quarter Horses.
An abnormal adherence of monocytes to fibronectin in thyroid autoimmunity has consequences for cell polarization and the development of veiled cells.
Analysis of heart-infiltrating T-cell clonotypes in experimental autoimmune myocarditis in rats.
Identification of a 48 kDa form of unconventional myosin 1c in blood serum of patients with autoimmune diseases.
IgG subclass reactivity to human cardiac myosin in cardiomyopathy patients is indicative of a Th1-like autoimmune disease.
Liver-Specific siRNA-Mediated Stat3 or C3 Knockdown Improves the Outcome of Experimental Autoimmune Myocarditis.
MYO9B polymorphisms in multiple sclerosis.
Myocarditis-inducing epitope of myosin binds constitutively and stably to I-Ak on antigen-presenting cells in the heart.
T cell mimicry and epitope specificity of cross-reactive T cell clones from rheumatic heart disease.
The characteristics of antibodies of mice immunized by human unconventional myosin 1c.
Avitaminosis
[The effect of alpha-tocopherol on changes in contractile and enzymic properties of myosin induced by avitaminosis K]
Bacterial Infections
Intestinal epithelial cell protein phosphorylation in enteropathogenic Escherichia coli diarrhoea.
Moesin and myosin IIA modulate phagolysosomal biogenesis in macrophages.
Bardet-Biedl Syndrome
A class III myosin expressed in the retina is a potential candidate for Bardet-Biedl syndrome.
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
The cloning and developmental expression of unconventional myosin IXA (MYO9A) a gene in the Bardet-Biedl syndrome (BBS4) region at chromosome 15q22-q23.
Biliary Atresia
Actin and myosin deposition around bile canaliculi: a predictor of clinical outcome in biliary atresia.
Blindness
EIAV-Based Retinal Gene Therapy in the shaker1 Mouse Model for Usher Syndrome Type 1B: Development of UshStat.
Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B.
Hereditary Retinal Dystrophy.
Myosin VIIa participates in opsin transport through the photoreceptor cilium.
Myosins and pathology: genetics and biology.
Novel myosin VI isoform is abundantly expressed in retina.
Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes.
Blister
A novel proteolytic cleavage of ROCK 1 in cell death: Not only by caspases 3 and 7 but also by caspase 2.
A short history of blebbing.
Apoptotic and necrotic blebs in epithelial cells display similar neck diameters but different kinase dependency.
Blebbistain, a myosin II inhibitor, as a novel strategy to regulate detrusor contractility in a rat model of partial bladder outlet obstruction.
Blebbistatin Modulates Prostatic Cell Growth and Contractility through Myosin II Signaling.
Blebs lead the way: how to migrate without lamellipodia.
Blebs on the move.
Blebs produced by actin-myosin contraction during apoptosis release damage-associated molecular pattern proteins before secondary necrosis occurs.
Bradykinin enhances invasion of malignant glioma into the brain parenchyma by inducing cells to undergo amoeboid migration.
Cell Blebbing in Confined Microfluidic Environments.
Cell mechanics control rapid transitions between blebs and lamellipodia during migration.
Cell migration: fibroblasts find a new way to get ahead.
Cell motility through plasma membrane blebbing.
Cell Surface Mechanochemistry and the Determinants of Bleb Formation, Healing, and Travel Velocity.
Correction: Interaction of c-Cbl with Myosin IIA Regulates Bleb Associated Macropinocytosis of Kaposi's Sarcoma-Associated Herpesvirus.
Death-associated protein kinase (DAPK) and signal transduction: blebbing in programmed cell death.
Deficiency of the 15-kDa selenoprotein led to cytoskeleton remodeling and non-apoptotic membrane blebbing through a RhoA/ROCK pathway.
Differential role of nonmuscle myosin II isoforms during blebbing of MCF-7 cells.
Diffusion of GPI-anchored proteins is influenced by the activity of dynamic cortical actin.
DMPK is a New Candidate Mediator of Tumor Suppressor p53-Dependent Cell Death.
Dynamic modes of the cortical actomyosin gel during cell locomotion and division.
Effects of the myosin inhibitor 2,3-butanedione monoxime (BDM) on cell shape, locomotion and fluid pinocytosis in human polymorphonuclear leucocytes.
Endoplasmic reticulum chaperone Gp96 controls actomyosin dynamics and protects against pore-forming toxins.
In vitro and in vivo relaxation of corpus cavernosum smooth muscle by the selective myosin II inhibitor, blebbistatin.
Inhibiting myosin-ATPase reveals a dynamic range of mitochondrial respiratory control in skeletal muscle.
Interaction of c-Cbl with myosin IIA regulates Bleb associated macropinocytosis of Kaposi's sarcoma-associated herpesvirus.
Involvement of ?- and ?-actin isoforms in actin cytoskeleton organization and migration abilities of bleb-forming human colon cancer cells.
Ischemia disrupts myosin I beta in renal tubules.
Membrane Blebbing Is Required for Mesenchymal Precursor Migration.
Myosin II-interacting guanine nucleotide exchange factor promotes bleb retraction via stimulating cortex reassembly at the bleb membrane.
Myosin IIA drives membrane bleb retraction.
Myosin IIB and F-Actin Control Apical Vacuolar Morphology and Histamine-Induced Trafficking of H,K-ATPase-Containing Tubulovesicles in Gastric Parietal Cells.
Myosin light chain kinase and Src control membrane dynamics in volume recovery from cell swelling.
Quantitating membrane bleb stiffness using AFM force spectroscopy and an optical sideview setup.
Quantitative Measurements of HIV-1 and Dextran Capture by Human Monocyte-derived Dendritic Cells (MDDCs).
Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression.
RacB regulates cytoskeletal function in Dictyostelium spp.
Relation between cell activity and the distribution of cytoplasmic actin and myosin.
Role of cortical tension in bleb growth.
Temporary increase in plasma membrane tension coordinates the activation of exocytosis and contraction during cell spreading.
The actin-myosin cytoskeleton mediates reversible agonist-induced membrane blebbing.
The role and regulation of blebs in cell migration.
Transition from mesenchymal to bleb-based motility is predominantly exhibited by CD133-positive subpopulation of fibrosarcoma cells.
Tropomyosin and caldesmon regulate cytokinesis speed and membrane stability during cell division.
Bone Resorption
Myosin II antibodies inhibit the resorption activity of isolated rat osteoclasts.
Bradycardia
Tyrosine hydroxylase is expressed during early heart development and is required for cardiac chamber formation.
[Factors predictive of early mortality after acute myocardial infarction]
Brain Diseases
Heterogeneity, distribution and endogenous phosphate content of KCl-myosins prepared from different parts of human brain.
Input-specific regulation of hippocampal circuit maturation by non-muscle myosin IIB.
Brain Edema
Adrenomedullin Reduces Secondary Injury and Improves Outcome in Rats with Fluid Percussion Brain Injury.
Recombinant Osteopontin Stabilizes Smooth Muscle Cell Phenotype via Integrin Receptor/Integrin-Linked Kinase/Rac-1 Pathway After Subarachnoid Hemorrhage in Rats.
Brain Injuries
Inhibition of myosin light chain kinase reduces NADPH oxidase-mediated oxidative injury in rat brain following cerebral ischemia/reperfusion.
Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness.
Brain Ischemia
Effects of insulin-like growth factor 1 on muscle atrophy and motor function in rats with brain ischemia.
Brain Neoplasms
The role of myosin II in glioma invasion of the brain.
Breast Neoplasms
?E-catenin is a candidate tumor suppressor for the development of E-cadherin-expressing lobular-type breast cancer.
A Proteomic Study of Myosin II Motor Proteins during Tumor Cell Migration.
Adipokine Leptin Co-operates With Mechanosensitive Ca2 +-Channels and Triggers Actomyosin-Mediated Motility of Breast Epithelial Cells.
CD44v(3,8-10) is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells.
Differential Depth Sensing Reduces Cancer Cell Proliferation via Rho-Rac-Regulated Invadopodia.
Differential Turnover of Myosin Chaperone UNC-45A Isoforms Increases in Metastatic Human Breast Cancer.
Distinct roles of nonmuscle myosin II isoforms in the regulation of MDA-MB-231 breast cancer cell spreading and migration.
DT-13 inhibits breast cancer cell migration via non-muscle myosin II-A regulation in tumor microenvironment synchronized adaptations.
Elevated expression of myosin X in tumours contributes to breast cancer aggressiveness and metastasis.
Exploiting differential effects of actomyosin contractility to control cell sorting among breast cancer cells.
Fluid flow-induced activation of subcellular AMPK and its interaction with FAK and Src.
Glabridin, an isoflavan from licorice root, inhibits migration, invasion and angiogenesis of MDA-MB-231 human breast adenocarcinoma cells by inhibiting focal adhesion kinase/Rho signaling pathway.
Heterogeneous distribution of actin, myosin, fibronectin and basement membrane antigens in primary and metastatic human breast cancer.
HSP47 promotes metastasis of breast cancer by interacting with myosin IIA via the unfolded protein response transducer IRE1?.
Identification of myosin in human epithelial cancers with immunofluorescence.
Identification of TG100-115 as a new and potent TRPM7 kinase inhibitor, which suppresses breast cancer cell migration and invasion.
Immunohistochemical studies on myoepithelial changes in breast tumors.
Induction of hypertrophy in vitro by mechanical loading in adult rabbit myocardium.
Integrin ?1, myosin light chain kinase and myosin IIA are required for activation of PI3K-AKT signaling following MEK inhibition in metastatic triple negative breast cancer.
Integrin alpha2-beta1 Mediates Tyrosine Phosphorylation of Vascular Endothelial Cadherin Induced by Invasive Breast Cancer Cells.
Ki-67 Membranous Staining: Biologically Relevant or an Artifact of Multiplexed Immunofluorescent Staining.
Lentivirus-Mediated Knockdown of Myosin VI Inhibits Cell Proliferation of Breast Cancer Cell.
Long non-coding RNA TUSC8 inhibits breast cancer growth and metastasis via miR-190b-5p/MYLIP axis.
LPA(1) -induced migration requires nonmuscle myosin II light chain phosphorylation in breast cancer cells.
Multi-sample deformability cytometry of cancer cells.
Myocardin-related transcription factor A is up-regulated by 17?-estradiol and promotes migration of MCF-7 breast cancer cells via transactivation of MYL9 and CYR61.
Myosin 1e promotes breast cancer malignancy by enhancing tumor cell proliferation and stimulating tumor cell de-differentiation.
Myosin IIa activation is crucial in breast cancer derived galectin-1 mediated tolerogenic dendritic cell differentiation.
Myosin IIA suppresses glioblastoma development in a mechanically sensitive manner.
Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2.
Myosin phosphorylation on stress fibers predicts contact guidance behavior across diverse breast cancer cells.
Non-Muscle Myosin II Isoforms Have Different Functions in Matrix Rearrangement by MDA-MB-231 Cells.
Non-muscle myosin IIA is post-translationally modified by interferon-stimulated gene 15 in breast cancer cells.
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Platelet-derived extracellular vesicles regulate cell cycle progression and cell migration in breast cancer cells.
Protease-activated receptor 2 promotes actomyosin dependent transforming microvesicles generation from human breast cancer.
Quinolinate Phosphoribosyltransferase Promotes Invasiveness of Breast Cancer Through Myosin Light Chain Phosphorylation.
SKELETAL MUSCLE ATROPHY AND DYSFUNCTION IN BREAST CANCER PATIENTS: ROLE FOR CHEMOTHERAPY-DERIVED OXIDANT STRESS.
The CDC42 effector protein MRCK? autophosphorylates on Threonine 1108.
The role of non-muscle myosin IIA in aggregation and invasion of human MCF-7 breast cancer cells.
Up-regulation of transcription of smooth muscle myosin alkali light chain by ethanol in human breast cancer cells.
Bronchial Spasm
Inhaled corticosteroids modulate the (+)insert smooth muscle myosin heavy chain in the equine asthmatic airways.
Perturbed equilibrium of myosin binding in airway smooth muscle and its implications in bronchospasm.
Capsule Opacification
Effect of H-7 on Secondary Cataract After Phacoemulsification in the Live Rabbit Eye.
Carcinogenesis
Actomyosin contractility modulates Wnt signaling through adherens junction stability.
Clinical phenotypes and molecular genetic mechanisms of Carney complex.
Extracellular matrix protein-1 secretory isoform promotes ovarian cancer through increasing alternative mRNA splicing and stemness.
Functional Characterization of Hepatitis B Virus X Protein Based on the Inhibition of Tumorigenesis in Nude Mice Injected with CCL13-HBx Cells.
GOLPH2 and MYO6: putative prostate cancer markers localized to the Golgi apparatus.
In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1-Rok-Myosin-II and JNK signalling.
Lentivirus-Mediated Knockdown of Myosin VI Inhibits Cell Proliferation of Breast Cancer Cell.
Long non-coding RNA (LncRNA) MRPL23-AS1 promotes tumor progression and carcinogenesis in osteosarcoma by activating Wnt/?-catenin signaling via inhibiting microRNA miR-30b and upregulating myosin heavy chain 9 (MYH9).
Mutation of perinatal myosin heavy chain associated with a Carney complex variant.
Myosin IIA suppresses glioblastoma development in a mechanically sensitive manner.
Myosins as fundamental components during tumorigenesis: diverse and indispensable.
NMIIA promotes tumorigenesis and prevents chemosensitivity in colorectal cancer by activating AMPK/mTOR pathway.
The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis.
Carcinoma
4H12, a Murine Monoclonal Antibody Directed against Myosin Heavy Chain-9 Expressed on Acinar Cell Carcinoma of Pancreas with Potential Therapeutic Application
Aberrant expression of MYH9 and E-cadherin in esophageal squamous cell carcinoma and their relationship to vasculogenic mimicry.
Analysis of Contractility and Invasion Potential of Two Canine Mammary Tumor Cell Lines.
Anti-smooth muscle antibodies (ASMAs) and anti-cytoskeleton antibodies (ACTAs) in liver diseases: a comparison of classical indirect immunofluorescence with ELISA.
Clinical significance of myosin in colorectal cancer.
Conditional deletion of nonmuscle myosin II-A in mouse tongue epithelium results in squamous cell carcinoma.
Dedifferentiation of stromal smooth muscle as a factor in prostate carcinogenesis.
Diagnostic utility of p75 neurotrophin receptor (p75NTR) as a marker of breast myoepithelial cells.
Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas.
Discriminating the earliest stages of mammary carcinoma using myoepithelial and proliferative markers.
Distribution of calponin and smooth muscle myosin heavy chain in fine-needle aspiration biopsies of the breast.
Distribution of myoepithelial cells and basement membrane proteins in the normal breast and in benign and malignant breast diseases.
Effects of Ultra-high doserate FLASH Irradiation on the Tumor Microenvironment in Lewis Lung Carcinoma: Role of Myosin Light Chain.
EphrinA1 activates a Src/focal adhesion kinase-mediated motility response leading to rho-dependent actino/myosin contractility.
Epithelial-myoepithelial carcinoma: an immunocytochemical study.
Evaluation of myosin VI, E-cadherin and beta-catenin immunostaining in renal cell carcinoma.
Expression and prognostic significance of MYL9 in esophageal squamous cell carcinoma.
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells.
Global Quantitative Proteomics reveal Deregulation of Cytoskeletal and Apoptotic Signalling Proteins in Oral Tongue Squamous Cell Carcinoma.
Hierarchical cluster analysis of myoepithelial/basal cell markers in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma.
Identification of the Myosin Heavy Polypeptide 9 as a Downstream Effector of the Proprotein Convertases in the Human Colon Carcinoma HT-29 Cells.
Identification of tumor-associated proteins in oral tongue squamous cell carcinoma by proteomics.
Immunohistochemical distinction of invasive from noninvasive breast lesions: a comparative study of p63 versus calponin and smooth muscle myosin heavy chain.
Immunohistochemical identification of actomyosin-containing (myoepithelial) cells in non-neoplastic and neoplastic tissues.
Immunohistochemical studies on expression of human vascular smooth muscle myosin heavy chain isoforms in normal mammary glands, benign mammary disorders and mammary carcinomas.
Immunohistochemical study of primary and recurrent basal cell and metatypical carcinomas of the skin.
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Immunophenotypic overlap between adenoid cystic carcinoma and collagenous spherulosis of the breast: potential diagnostic pitfalls using myoepithelial markers.
Increase of contractile proteins in human cancer cells.
Knockdown of Myosin 6 inhibits proliferation of oral squamous cell carcinoma cells.
Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer.
LIF mediates proinvasive activation of stromal fibroblasts in cancer.
Loss of E-Cadherin-Dependent Cell-Cell Adhesion and the Development and Progression of Cancer.
Metastatic basal cell carcinoma exhibits reduced actin expression.
MYH9 promotes cell metastasis via inducing Angiogenesis and Epithelial Mesenchymal Transition in Esophageal Squamous Cell Carcinoma.
Myosin 1b promotes cell proliferation, migration, and invasion in cervical cancer.
Myosin 5a regulates tumor migration and epithelial-mesenchymal transition in esophageal squamous cell carcinoma: utility as a prognostic factor.
Myosin from pancreatic acinar carcinoma cells. Isolation, characterization and demonstration of heavy- and light-chain phosphorylation.
Non-muscle myosin II as a predictive factor in head and neck squamous cell carcinoma.
Non-Muscle Myosin IIa Heavy Chain Links Squamous-Cell Carcinoma of the Head and Neck to the DNA Damage Response.
Non-muscle myosin IIB is critical for nuclear translocation during 3D invasion.
Normal and neoplastic myoepithelial cells in salivary glands: an immunohistochemical study.
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Proteome of Metastatic Canine Mammary Carcinomas: Similarities to and Differences from Human Breast Cancer (†).
S100A4/Nonmuscle Myosin IIA/p53 Axis Contributes to Aggressive Features in Ovarian High-Grade Serous Carcinoma.
Salivary epithelial-myoepithelial carcinomas of intercalated ducts: a clinical, electron microscopic, and immunocytochemical study.
The localization of cytoskeletal proteins and thyroglobulin in thyroid microcarcinoma in comparison with clinically manifested thyroid carcinoma.
The proportions of fiber types in human external urethral sphincter: electrophoretic analysis of myosin.
The stressed cytoskeleton: How actin dynamics can shape stress-related consequences on synaptic plasticity and complex behavior.
Use of immunohistochemistry in the diagnosis of problematic breast lesions.
Vimentin and Non-Muscle Myosin IIA are Members of the Neural Precursor Cell Expressed Developmentally Down-Regulated 9 (NEDD9) Interactome in Head and Neck Squamous Cell Carcinoma Cells.
[Immunocytochemical study of the myoepithelial cells in fibrocystic disease and ductal carcinoma of the breast]
[Immunoelectron microscopic and immunohistochemical study of adenoid cystic carcinoma of the salivary gland]
[The contractile filament system of carcinoma cells. Immunofluorescent and electron microscopic study]
Carcinoma in Situ
Diagnostic utility of p75 neurotrophin receptor (p75NTR) as a marker of breast myoepithelial cells.
Carcinoma, Acinar Cell
4H12, a Murine Monoclonal Antibody Directed against Myosin Heavy Chain-9 Expressed on Acinar Cell Carcinoma of Pancreas with Potential Therapeutic Application
Myosin from pancreatic acinar carcinoma cells. Isolation, characterization and demonstration of heavy- and light-chain phosphorylation.
Carcinoma, Adenoid Cystic
Hierarchical cluster analysis of myoepithelial/basal cell markers in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma.
Immunohistochemical identification of actomyosin-containing (myoepithelial) cells in non-neoplastic and neoplastic tissues.
Immunophenotypic overlap between adenoid cystic carcinoma and collagenous spherulosis of the breast: potential diagnostic pitfalls using myoepithelial markers.
Normal and neoplastic myoepithelial cells in salivary glands: an immunohistochemical study.
[Immunoelectron microscopic and immunohistochemical study of adenoid cystic carcinoma of the salivary gland]
Carcinoma, Basal Cell
Metastatic basal cell carcinoma exhibits reduced actin expression.
Carcinoma, Ductal
Diagnostic utility of p75 neurotrophin receptor (p75NTR) as a marker of breast myoepithelial cells.
Myoepithelial cell staining patterns of papillary breast lesions: from intraductal papillomas to invasive papillary carcinomas.
Use of immunohistochemistry in the diagnosis of problematic breast lesions.
Carcinoma, Ehrlich Tumor
Actin-like filaments in Ehrlich ascites tumor cells and their reaction with heavy meromyosin.
Fluorescence and electron microscopic study of intracellular F-actin in concanavalin A-treated and cytochalasin B-treated Ehrlich ascites tumor cells.
Possible interrelationship between changes in F-actin and myosin II, protein phosphorylation, and cell volume regulation in Ehrlich ascites tumor cells.
Purification of myosin from Ehrlich ascites tumour cells (phosphorylation of its light chain and heavy chain).
Shrinkage insensitivity of NKCC1 in myosin II-depleted cytoplasts from Ehrlich ascites tumor cells.
Carcinoma, Embryonal
Actin and myosin expression during development of cardiac muscle from cultured embryonal carcinoma cells.
Organization of non-muscle myosin during early murine embryonic differentiation.
Carcinoma, Hepatocellular
Cooperation of fibronectin with lysophosphatidic acid induces motility and transcellular migration of rat ascites hepatoma cells.
HBx-upregulated MAFG-AS1 promotes cell proliferation and migration of hepatoma cells by enhancing MAFG expression and stabilizing nonmuscle myosin IIA.
Knockdown of myosin VI inhibits proliferation of hepatocellular carcinoma cells in vitro.
MR-1 modulates proliferation and migration of human hepatoma HepG2 cells through myosin light chains-2 (MLC2)/focal adhesion kinase (FAK)/Akt signaling pathway.
The cytoskeletal inhibitors latrunculin A and blebbistatin exert antitumorigenic properties in human hepatocellular carcinoma cells by interfering with intracellular HuR trafficking.
The purification and quantitation of myosin from cultured cells.
Carcinoma, Intraductal, Noninfiltrating
Morphologic, molecular and microenvironment factors associated with stromal invasion in breast ductal carcinoma in situ: Role of myoepithelial cells.
Myoepithelial cell staining patterns of papillary breast lesions: from intraductal papillomas to invasive papillary carcinomas.
Phenotypic alterations in ductal carcinoma in situ-associated myoepithelial cells: biologic and diagnostic implications.
Use of immunohistochemistry in the diagnosis of problematic breast lesions.
Carcinoma, Lewis Lung
Effects of Ultra-high doserate FLASH Irradiation on the Tumor Microenvironment in Lewis Lung Carcinoma: Role of Myosin Light Chain.
Carcinoma, Lobular
Diagnostic utility of p75 neurotrophin receptor (p75NTR) as a marker of breast myoepithelial cells.
[Role of myoepithelial cells in the histogenesis of lobular breast cancer]
Carcinoma, Non-Small-Cell Lung
Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer.
Carcinoma, Ovarian Epithelial
miR-6089/MYH9/?-catenin/c-Jun negative feedback loop inhibits ovarian cancer carcinogenesis and progression.
MYH9 overexpression correlates with clinicopathological parameters and poor prognosis of epithelial ovarian cancer.
Carcinoma, Papillary
Diagnostic utility of p75 neurotrophin receptor (p75NTR) as a marker of breast myoepithelial cells.
Myoepithelial cell staining patterns of papillary breast lesions: from intraductal papillomas to invasive papillary carcinomas.
New trends of immunohistochemistry for making differential diagnosis of breast lesions.
Papillary carcinoma of the breast: an overview.
Carcinoma, Renal Cell
Evaluation of myosin VI, E-cadherin and beta-catenin immunostaining in renal cell carcinoma.
Identification of myosin in human epithelial cancers with immunofluorescence.
The stressed cytoskeleton: How actin dynamics can shape stress-related consequences on synaptic plasticity and complex behavior.
Carcinoma, Squamous Cell
Conditional deletion of nonmuscle myosin II-A in mouse tongue epithelium results in squamous cell carcinoma.
Differential phosphorylation events associated with phorbol ester effects on acceleration versus inhibition of cell growth.
Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas.
Myosin 1b promotes cell proliferation, migration, and invasion in cervical cancer.
Non-muscle myosin II as a predictive factor in head and neck squamous cell carcinoma.
ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma.
Vimentin and Non-Muscle Myosin IIA are Members of the Neural Precursor Cell Expressed Developmentally Down-Regulated 9 (NEDD9) Interactome in Head and Neck Squamous Cell Carcinoma Cells.
Carcinosarcoma
Role of Rho, Rac, and Rho-kinase in phosphorylation of myosin light chain, development of polarity, and spontaneous migration of Walker 256 carcinosarcoma cells.
S100A4/non-muscle myosin II signaling regulates epithelial-mesenchymal transition and stemness in uterine carcinosarcoma.
Cardiomegaly
A ternary complex of transcription factors, Nishéd and NFATc4, and co-activator p300 bound to an intronic sequence, intronic regulatory element, is pivotal for the up-regulation of myosin light chain-2v gene in cardiac hypertrophy.
Alpha 1-adrenergic stimulation of cardiac gene transcription in neonatal rat myocardial cells. Effects on myosin light chain-2 gene expression.
Alpha-skeletal muscle actin mRNA's accumulate in hypertrophied adult rat hearts.
Alterations of substances (DNA, myoglobin, myosin, protein) in experimentally induced cardiac hypertrophy and under the influence of drugs (isoproterenol, cytostatics, strophanthin).
Altered myosin isozyme patterns from pressure-overloaded and thyrotoxic hypertrophied rabbit hearts.
Angiotensin II maintains, but does not mediate, isoproterenol-induced cardiac hypertrophy in rats.
Angiotensin type 2 receptor agonist compound 21 reduces vascular injury and myocardial fibrosis in stroke-prone spontaneously hypertensive rats.
Antithetical accumulation of myosin heavy chain but not alpha-actin mRNA isoforms during early stages of pressure-overload-induced rat cardiac hypertrophy.
Apigenin Attenuates Experimental Autoimmune Myocarditis by Modulating Th1/Th2 Cytokine Balance in Mice.
Are calcineurin genes associated with endurance phenotype traits?
ATPase activity of the cross-linked complex between cardiac myosin subfragment 1 and actin in several models of chronic overloading. A new approach to the biochemistry of contractility.
Biochemical characterization of ventricular myosin from spontaneously hypertensive turkeys.
Biochemical correlates of cardiac hypertrophy. V. Labeling of collagen, myosin, and nuclear DNA during experimental myocardial hypertrophy in the rat.
Canine cardiac myosin with special reference to pressure overload cardiac hypertrophy. II. Myosin ATPase.
Canine cardiac myosin with special referrence to pressure overload cardiac hypertrophy. I. Subunit composition.
Cardiac hypertrophy alters expression of Na+,K(+)-ATPase subunit isoforms at mRNA and protein levels in rat myocardium.
Cardiac hypertrophy and failure--a disease of adaptation. Modifications in membrane proteins provide a molecular basis for arrhythmogenicity.
Cardiac hypertrophy: old concepts, new perspectives.
Cardiac myosin: preparation, ATPase in chronic heart hypertrophy.
Cardiomyopathic mutations in essential light chain reveal mechanisms regulating the super relaxed state of myosin.
Chagas' disease: polyspecificity of antibodies against Trypanosoma cruzi acidic antigens.
Changes in myosin and creatine kinase mRNA levels with cardiac hypertrophy and hypothyroidism.
Changes in myosin isozyme expression during cardiac hypertrophy in hyperthyroid rabbits.
Characterization of the decreased ATPase activity of rat cardiac actomyosin in isoproterenol-induced cardiac hypertrophy.
Chronic cardiac reactions. II. Mechanical and energetic consequences of myocardial transformation versus ventricular dilatation in the chronically pressure-loaded heart.
Contractile systolic and diastolic dysfunction in renin-induced hypertensive cardiomyopathy.
Control of myosin heavy chain expression in cardiac hypertrophy.
Correlation of myosin heavy chain expression in the rat with cAMP in different models of hypertension-induced cardiac hypertrophy.
Cross-bridge kinetics in myofibrils containing familial hypertrophic cardiomyopathy R58Q mutation in the regulatory light chain of myosin.
Deletion of Kv?1.1 subunit leads to electrical and haemodynamic changes causing cardiac hypertrophy in female murine hearts.
Dexamethasone induced cardiac hypertrophy in newborn rats is accompanied by changes in myosin heavy chain phenotype and gene transcription.
Differences in myosin isoform expression in the subepicardial and subendocardial myocardium during cardiac hypertrophy in the rat.
Different distributions of microtubules, desmin filaments and isomyosins during the onset of cardiac hypertrophy in the rat.
Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes.
Dissociation of cardiac hypertrophy, myosin heavy chain isoform expression, and natriuretic peptide production in DOCA-salt rats.
Effect of aging and hypertension on beta-myosin heavy chain in heart of spontaneously hypertensive rats.
Effect of cytosol on the regulation of expression of myosin heavy chain genes during cardiac hypertrophy.
Effect of long-term treatment with beta-blocker on cardiac hypertrophy in SHR.
Effect of sodium deprivation on cardiac hypertrophy in spontaneously hypertensive rats: influence of aging.
Effects of chronic dobutamine administration on hearts of normal and hypertensive rats.
Effects of delapril hydrochloride on the myocardium of spontaneously hypertensive rats.
Effects of long term treatment with an alpha 1 adrenoceptor blocker on cardiac hypertrophy, contractility, and myosin isoenzymes in spontaneously hypertensive rats.
Effects of Modest Hypoxia and Exercise on Cardiac Function, Sleep-Activity, Negative Geotaxis Behavior of Aged Female Drosophila.
Effects of regression of cardiac hypertrophy on myocardial contractility and ventricular myosin isoenzymes.
Endocrine and cardiac paracrine actions of insulin-like growth factor-I (IGF-I) during thyroid dysfunction in the rat: is IGF-I implicated in the mechanism of heart weight/body weight change during abnormal thyroid function?
Endogenous endothelin-1 mediates cardiac hypertrophy and switching of myosin heavy chain gene expression in rat ventricular myocardium.
Epigenetic control of exercise training-induced cardiac hypertrophy by miR-208.
Follistatin Attenuates Myocardial Fibrosis in Diabetic Cardiomyopathy via the TGF-?-Smad3 Pathway.
Genetic analysis of the Irx4 gene in hypertrophic cardiomyopathy.
Gonadectomy and hormonal replacement changes systolic blood pressure and ventricular myosin isoenzyme pattern of spontaneously hypertensive rats.
gp130 plays a critical role in pressure overload-induced cardiac hypertrophy.
Guanine nucleotide exchange factor-like factor (Rlf) induces gene expression and potentiates alpha 1-adrenergic receptor-induced transcriptional responses in neonatal rat ventricular myocytes.
Hemodynamics and mitochondrial energy metabolism in right heart hypertrophy after acute hypoxic stress.
Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism.
Impaired skeletal muscle performance in the early stage of cardiac pressure overload in rabbits: beneficial effects of angiotensin-converting enzyme inhibition.
Inactivation of Myosin binding protein C homolog in zebrafish as a model for human cardiac hypertrophy and diastolic dysfunction.
Increased synthesis of the phosphorylated form of the myosin light chains in cardiac hypertrophy in the rat.
Induced Pluripotent Stem Cell-Derived Cardiomyocytes from a Patient with MYL2-R58Q-Mediated Apical Hypertrophic Cardiomyopathy Show Hypertrophy, Myofibrillar Disarray, and Calcium Perturbations.
Insulin-like growth factor-I induces hypertrophy with enhanced expression of muscle specific genes in cultured rat cardiomyocytes.
Insulin-like growth factor-II induces hypertrophy with increased expression of muscle specific genes in cultured rat cardiomyocytes.
Investigating the relaxation rate, following diazo-2 photolysis, of a skinned trabecular preparation from guinea-pig hypertrophied left ventricle.
Investigating the relaxation, following diazo-2 laser flash photolysis, of a skinned trabecular preparation from SHR hypertrophied left ventricle.
Iron overload exacerbates age-associated cardiac hypertrophy in a mouse model of hemochromatosis.
Isomyosin distribution in normal and pressure-overloaded rat ventricular myocardium. An immunohistochemical study.
Isoproterenol-induced cardiomegaly: assessment of myocardial protein content, actomyosin ATPase and heart rate.
Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis.
l-Arginine Attenuates Cardiac Dysfunction, But Further Down-Regulates ?-Myosin Heavy Chain Expression in Isoproterenol-Induced Cardiomyopathy.
Lrrc10 is required for early heart development and function in zebrafish.
Male sex aggravates the phenotype in mouse models of hypertrophic cardiomyopathy.
Mep1a contributes to Ang II-induced cardiac remodeling by promoting cardiac hypertrophy, fibrosis and inflammation.
miR-155 functions downstream of angiotensin II receptor subtype 1 and calcineurin to regulate cardiac hypertrophy.
Modification of subcellular organelles in pressure-overloaded heart by etomoxir, a carnitine palmitoyltransferase I inhibitor.
Modulation of angiotensin II-mediated cardiac remodeling by the MEF2A target gene Xirp2.
Modulation of contractility in human cardiac hypertrophy by myosin essential light chain isoforms.
Modulation of in vivo cardiac hypertrophy with insulin-like growth factor-1 and angiotensin-converting enzyme inhibitor: relationship between change in myosin isoform and progression of left ventricular dysfunction.
Molecular manifestations of cardiac hypertrophy in the spontaneously hypertensive rat effects of antihypertensive treatments.
Multidimensional structure-function relationships in human ?-cardiac myosin from population-scale genetic variation.
Myocardial contractility and energetics in cardiac hypertrophy and its regression.
Myocardial contractility and left ventricular myosin isoenzyme pattern in cardiac hypertrophy due to chronic volume overload.
Myocardial contractility and ventricular myosin isoenzymes as influenced by cardiac hypertrophy and its regression.
Myofibrillar protein turnover in cardiac hypertrophy due to aortic regurgitation.
Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation in Drosophila.
Myosin heavy chain expression and atrophy in rat skeletal muscle during transition from cardiac hypertrophy to heart failure.
Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals.
Myosin isoenzyme changes in several models of rat cardiac hypertrophy.
Myosin isoenzymes in normal and hypertrophied human ventricular myocardium.
Myosin light chain phosphorylation in cardiac hypertrophy and failure due to myocardial infarction.
Myosin regulatory light chain phosphorylation attenuates cardiac hypertrophy.
Myosin synthesis and degradation during development of cardiac hypertrophy in the rabbit.
Nonsynchronous accumulation of alpha-skeletal actin and beta-myosin heavy chain mRNAs during early stages of pressure-overload--induced cardiac hypertrophy demonstrated by in situ hybridization.
Overexpression of the serotonin 5-HT2B receptor in heart leads to abnormal mitochondrial function and cardiac hypertrophy.
Peripheral benzodiazepine receptor ligand Ro5-4864 inhibits isoprenaline-induced cardiac hypertrophy in rats.
Pharmacokinetics, antitumor and cardioprotective effects of liposome-encapsulated phenylaminoethyl selenide in human prostate cancer rodent models.
Preventive training does not interfere with mRNA-encoding myosin and collagen expression during pulmonary arterial hypertension.
Progression and regression of cardiac hypertrophy in hypertensive rats: biochemical and molecular changes in ventricular myosin.
Recombinant cardiac myosin fragment induces experimental autoimmune myocarditis via activation of Th1 and Th17 immunity.
Recovery of left ventricular function following in vivo reexpression of cardiac myosin binding protein C.
Regional myosin heavy chain expression in volume and pressure overload induced cardiac hypertrophy.
Regression of cardiac hypertrophy and myosin isoenzyme patterns by losartan and captopril in renovascular hypertensive rats.
Regression of cardiac hypertrophy in spontaneously hypertensive rats by enalapril and the expression of contractile proteins.
Regular exercise improves cardiac contractile activation by modulating MHC isoforms and SERCA activity in orchidectomized rats.
Regulation of antisense RNA expression during cardiac MHC gene switching in response to pressure overload.
Regulation of expression of contractile proteins with cardiac hypertrophy and failure.
Regulation of myosin heavy chain expression in the hearts of hypertensive rats by testosterone.
Relationship between myosin isoenzyme composition, hemodynamics, and myocardial structure in various forms of human cardiac hypertrophy.
Remodeling of the heart in hypertrophy in animal models with myosin essential light chain mutations.
Replacement of myosin during development of cardiac hypertrophy.
Reversible epigenetic modifications of the two cardiac myosin heavy chain genes during changes in expression.
Skeletal muscle myosin heavy chain expression in rats with monocrotaline-induced cardiac hypertrophy and failure. Relation to blood flow and degree of muscle atrophy.
Species correlations between cardiac isomyosins. A comparison of electrophoretic and immunological properties.
Structural and functional properties of myosin associated with the compensatory cardiac hypertrophy in the rabbit.
Studies on adenosine triphosphatase activity of rat cardiac myosin in isoproterenol-induced cardiac hypertrophy.
Studies on the substructure of myosin in cardiac hypertrophy. Characterization of light chains.
Studies on the superprecipitation of actomyosin in isoproterenol-induced cardiac hypertrophy.
Subcellular remodeling and heart dysfunction in cardiac hypertrophy due to pressure overload.
Sucrose feeding prevents changes in myosin isoenzymes and sarcoplasmic reticulum Ca2+-pump ATPase in pressure-loaded rat heart.
The cardiac beta-myosin heavy chain isogene is induced selectively in alpha 1-adrenergic receptor-stimulated hypertrophy of cultured rat heart myocytes.
The molecular biology of heart failure.
The morphology of myosin in cardiac hypertrophy.
The mTOR/p70S6K signal transduction pathway plays a role in cardiac hypertrophy and influences expression of myosin heavy chain genes in vivo.
The myosin gene switching in human cardiac hypertrophy.
The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart.
The stretch-activation response may be critical to the proper functioning of the mammalian heart.
Thyroxine-induced cardiomegaly: assessment of nucleic acid, protein content and myosin ATPase of rat heart.
Troponin I phosphorylation and myofilament calcium sensitivity during decompensated cardiac hypertrophy.
Ubiquitin-protein ligase E3a (UBE3A) as a new biomarker of cardiac hypertrophy in cell models.
Unchanged myosin kinase activity in hypertrophied rat heart.
Ventricular myosin pattern of spontaneously hypertensive turkeys is unaffected by labetalol treatment.
[Genetic changes and clinical management in familial hypertrophic cardiomyopathy]
[Molecular basis for heart failure]
[Myosin and cardiac hypertrophy]
[Parameter of contractility, myosin-ATPase and heart hypertrophy in a slowly increasing blood pressure load of the guinea pig's heart. Studies on development of chronic heart hypertrophy model for small laboratory animals]
[Regulation of the myosin heavy chain gene expression during cardiac hypertrophy induced by pressure-overload]
[The advances of research for cardiac contractile proteins structure and function]
[Variation of mechanical and biochemical parameters of pressure-loaded rabbit hearts following chronic administration of dipyridamole]
Cardiomyopathies
A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart.
A Cardiomyopathy Mutation in the Myosin Essential Light Chain Alters Actomyosin Structure.
A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia.
A Failure to Communicate: MYOSIN RESIDUES INVOLVED IN HYPERTROPHIC CARDIOMYOPATHY AFFECT INTER-DOMAIN INTERACTION.
A Novel Alpha Cardiac Actin (ACTC1) Mutation Mapping to a Domain in Close Contact with Myosin Heavy Chain Leads to a Variety of Congenital Heart Defects, Arrhythmia and Possibly Midline Defects.
A novel mutation expands the genetic and clinical spectrum of MYH7-related myopathies.
A variable domain near the ATP-binding site in Drosophila muscle myosin is part of the communication pathway between the nucleotide and actin-binding sites.
Adenosine diphosphate effect on contractility of human muscle actomyosin: inhibition by ethanol and acetaldehyde.
Advanced Evolution of Pathogenesis Concepts in Cardiomyopathies.
All-atom molecular dynamics simulations of actin-myosin interactions: a comparative study of cardiac ? myosin, ? myosin, and fast skeletal muscle myosin.
Altered interactions between cardiac myosin binding protein-C and ?-cardiac actin variants associated with cardiomyopathies.
Altered myofilament stoichiometry in response to heart failure in a cardioprotective ?-myosin heavy chain transgenic rabbit model.
Antigen-Based Nano-Immunotherapy Controls Parasite Persistence, Inflammatory and Oxidative Stress, and Cardiac Fibrosis, the Hallmarks of Chronic Chagas Cardiomyopathy, in A Mouse Model of Trypanosoma cruzi Infection.
Atomic model of the human cardiac muscle myosin filament.
Autoimmunity in Chagas' disease. Identification of cardiac myosin-B13 Trypanosoma cruzi protein crossreactive T cell clones in heart lesions of a chronic Chagas' cardiomyopathy patient.
Autosomal recessive cardiomyopathy and sudden cardiac death associated with variants in MYL3.
A Dutch MYH7 founder mutation, p.(Asn1918Lys), is associated with early onset cardiomyopathy and congenital heart defects.
Biological, biochemical, and kinetic effects of mutations of the cardiomyopathy loop of Dictyostelium myosin II: importance of ALA400.
Calcium sensitivity and myosin light chain pattern of atrial and ventricular skinned cardiac fibers from patients with various kinds of cardiac disease.
cAPK-phosphorylation controls the interaction of the regulatory domain of cardiac myosin binding protein C with myosin-S2 in an on-off fashion.
Cardiac antigen-specific autoantibody production is associated with cardiomyopathy in Trypanosoma cruzi-infected mice.
Cardiac myosin heavy chain isoform exchange alters the phenotype of cTnT-related cardiomyopathies in mouse hearts.
Cardiomyopathic mutations in essential light chain reveal mechanisms regulating the super relaxed state of myosin.
Cardiomyopathy - An approach to the autoimmune background.
Cardiomyopathy associated with noninsulin-dependent diabetes.
Cardiomyopathy mutations impact the actin-activated power stroke of human cardiac myosin.
Cardiomyopathy mutations in the tail of beta cardiac myosin modify the coiled-coil structure and affect integration into thick filaments in muscle sarcomeres in adult cardiomyocytes.
Cardiomyopathy mutations reveal variable region of myosin converter as major element of cross-bridge compliance.
Cardiomyopathy-associated mutations in tropomyosin differently affect actin-myosin interaction at single-molecule and ensemble levels.
Cardiomyopathy: A Systematic Review of Disease-Causing Mutations in Myosin Heavy Chain 7 and Their Phenotypic Manifestations.
Changes in essential myosin light chain isoform expression provide a molecular basis for isometric force regulation in the failing human heart.
Characterization and distribution of myosin variants in normal and pathological human hearts.
Consequences of unlocking the cardiac myosin molecule in human myocarditis and cardiomyopathies.
Construction and characterization of the alpha form of a cardiac myosin heavy chain cDNA clone and its developmental expression in the Syrian hamster.
Contractile and cytoskeletal content, structure, and mRNA levels with tachycardia-induced cardiomyopathy.
Crossbridge Recruitment Capacity of Wild-Type and Hypertrophic Cardiomyopathy-Related Mutant Troponin-T Evaluated by X-ray Diffraction and Mechanical Study of Cardiac Skinned Fibers.
Cytoskeletal-antigen specific immunoliposomes: preservation of myocardial viability.
Deciphering the super relaxed state of human ?-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers.
Digenic mutational inheritance of the integrin alpha 7 and the myosin heavy chain 7B genes causes congenital myopathy with left ventricular non-compact cardiomyopathy.
Direct and Indirect Involvement of MicroRNA-499 in Clinical and Experimental Cardiomyopathy.
Distribution of cardiac myosin isozymes in cardiomyopathy: immunohistochemical and gene analysis.
Drosophila model of myosin myopathy rescued by overexpression of a TRIM-protein family member.
Dysfunction of Myosin Light-Chain 4 (MYL4) Leads to Heritable Atrial Cardiomyopathy With Electrical, Contractile, and Structural Components: Evidence From Genetically-Engineered Rats.
Effect of trimetazidine and verapamil on the cardiomyopathic hamster myosin phenotype.
Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human ?-cardiac myosin.
Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector.
Essential light chain S195 phosphorylation is required for cardiac adaptation under physical stress.
Evidence of autoantibodies against cardiac troponin I and sarcomeric myosin in peripartum cardiomyopathy.
Expression of atrial myosin light chains but not alpha-myosin heavy chains is correlated in vivo with increased ventricular function in patients with hypertrophic obstructive cardiomyopathy.
Fiber types and myosin types in human atrial and ventricular myocardium. An anatomical description.
From Genetic Mutations to Molecular Basis of Heart Failure Treatment: An Overview of the Mechanism and Implication of the Novel Modulators for Cardiac Myosin.
Heart failure-associated changes in RNA splicing of sarcomere genes.
Heat stress in rat adriamycin cardiomyopathy: heat shock protein 25 and Myosin accumulation.
Hereditary heart disease: pathophysiology, clinical presentation, and animal models of HCM, RCM, and DCM associated with mutations in cardiac myosin light chains.
Hereditary myosin myopathies.
Histochemistry of ventricular heavy-chain myosins in cardiomyopathic Syrian hamsters treated with D-600.
HLA and beta-myosin heavy chain do not influence susceptibility to Chagas disease cardiomyopathy.
Homozygous mutation in MYH7 in myosin storage myopathy and cardiomyopathy.
Human disease caused by loss of fast IIa myosin heavy chain due to recessive MYH2 mutations.
Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the Drosophila heart.
Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alpha-cardiac myosin in the laser trap assay.
Hypoxic right ventricular cardiomyopathy. A morphological and pathogenetic study on the myocardial atrophy and fatty infiltration.
Identification of pathogenic gene mutations in LMNA and MYBPC3 that alter RNA splicing.
IgG subclass reactivity to human cardiac myosin in cardiomyopathy patients is indicative of a Th1-like autoimmune disease.
Impact of pregnancy-related heart failure on humoral immunity: clinical relevance of G3-subclass immunoglobulins in peripartum cardiomyopathy.
Impact of regulatory light chain mutation K104E on the ATPase and motor properties of cardiac myosin.
Impaired myosin isoform shift and calcium transients contribute to cellular pathogenesis of rat cirrhotic cardiomyopathy.
In the Thick of It: HCM-Causing Mutations in Myosin Binding Proteins of the Thick Filament.
In vitro rescue study of a malignant familial hypertrophic cardiomyopathy phenotype by pseudo-phosphorylation of myosin regulatory light chain.
Increased myosin heavy chain-beta with atrial expression of ventricular light chain-2 in canine cardiomyopathy.
Indium-111 antimyosin monoclonal antibody Fab imaging in patients with cardiomyopathy.
Inherited cardiomyopathies as a troponin disease.
Mechanical defects of muscle fibers with myosin light chain mutants that cause cardiomyopathy.
Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy.
Modulating Beta-Cardiac Myosin Function at the Molecular and Tissue Levels.
Modulation of cardiac performance by motor protein gene transfer.
Molecular and Functional Effects of a Splice Site Mutation in the MYL2 Gene Associated with Cardioskeletal Myopathy and Early Cardiac Death in Infants.
Molecular mechanisms of cardiomyopathy phenotypes associated with myosin light chain mutations.
Molecular mimicry between cardiac myosin and Trypanosoma cruzi antigen B13: identification of a B13-driven human T cell clone that recognizes cardiac myosin.
Mutations in the skeletal muscle alpha-actin gene in patients with actin myopathy and nemaline myopathy.
Mutations in the slow skeletal muscle fiber myosin heavy chain gene (MYH7) cause laing early-onset distal myopathy (MPD1).
MYH7 mutation associated with two phenotypes of myopathy.
MYH7-related disorders in two Bulgarian families: Novel variants in the same region associated with different clinical manifestation and disease penetrance.
Myofibroblast-Specific TGF? Receptor II Signaling in the Fibrotic Response to Cardiac Myosin Binding Protein C-Induced Cardiomyopathy.
Myosin binding protein C: implications for signal-transduction.
Myosin binding protein-C activates thin filaments and inhibits thick filaments in heart muscle cells.
Myosin light chain mutation causes autosomal recessive cardiomyopathy with mid-cavitary hypertrophy and restrictive physiology.
Myosin storage myopathy with cardiomyopathy.
Myosin VI and cardiomyopathy: Left ventricular hypertrophy, fibrosis, and both cardiac and pulmonary vascular endothelial cell defects in the Snell's waltzer mouse.
Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains.
Myosin VI facilitates connexin 43 gap junction accretion.
Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene.
New application of myocardial antimyosin scintigraphy: diagnosis of myocardial disease in polymyositis.
Novel Adult-Onset Systolic Cardiomyopathy Due to MYH7 E848G Mutation in Patient-Derived Induced Pluripotent Stem Cells.
Novel Mutations Widen the Phenotypic Spectrum of Slow Skeletal/?-Cardiac Myosin (MYH7) Distal Myopathy.
Novel phenotypic variant in the MYH7 spectrum due to a stop-loss mutation in the C-terminal region: a case report.
Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation.
Phenotype and prognostic correlations of the converter region mutations affecting the ? myosin heavy chain.
Phosphorylation status of regulatory proteins and functional characteristics in myocardium of dilated cardiomyopathy of Syrian hamsters.
Poor Myocardial Compaction in a Patient with Recessive MYL2 Myopathy.
Pressure Overload Is Associated With Low Levels of Troponin I and Myosin Binding Protein C Phosphorylation in the Hearts of Patients With Aortic Stenosis.
Protein metabolism in alcoholism: effects on specific tissues and the whole body.
Protein-protein interactions in actin-myosin binding and structural effects of R405Q mutation: a molecular dynamics study.
Pseudophosphorylation of cardiac myosin regulatory light chain: a promising new tool for treatment of cardiomyopathy.
Ramipril restores PPAR?/? and PPAR? expressions and reduces cardiac NADPH oxidase but fails to restore cardiac function and accompanied myosin heavy chain ratio shift in severe anthracycline-induced cardiomyopathy in rat.
Redox-sensitive residue in the actin-binding interface of myosin.
Reduced length-dependent cross-bridge recruitment in skinned fiber preparations of human failing myocardium.
Regulatory light chain mutations associated with cardiomyopathy affect myosin mechanics and kinetics.
Regulatory proteins in hamster cardiomyopathy.
Role of cytokines in autoimmune myocarditis and cardiomyopathy.
Sarcomere mutations in cardiomyopathy with left ventricular hypertrabeculation.
Several cardiomyopathy causing mutations on tropomyosin either destabilize the active state of actomyosin or alter the binding properties of tropomyosin.
Some cardiomyopathy-causing troponin I mutations stabilize a functional intermediate actin state.
Structural and functional impact of site-directed methionine oxidation in myosin.
Structure, stability and dynamics of the central domain of cardiac myosin binding protein C (MyBP-C): implications for multidomain assembly and causes for cardiomyopathy.
The Cardiac Myosin Binding Protein C Arg502Trp Mutation. A Common Cause of Hypertrophic Cardiomyopathy.
The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy.
The regulatory effects of tropomyosin and troponin-I on the interaction of myosin loop regions with F-actin.
The Structure of Acto-Myosin.
The structure, function, and turnover of cardiac myosin in normal and myopathic Syrian hamsters.
The UNC-45 Chaperone Is Critical for Establishing Myosin-Based Myofibrillar Organization and Cardiac Contractility in the Drosophila Heart Model.
Three-dimensional structure of the human myosin thick filament: clinical implications.
Transgenic expression of replication-restricted enteroviral genomes in heart muscle induces defective excitation-contraction coupling and dilated cardiomyopathy.
Truncation of vertebrate striated muscle myosin light chains disturbs calcium-induced structural transitions in synthetic myosin filaments.
Two Drosophila Myosin Transducer Mutants with Distinct Cardiomyopathies Have Divergent ADP and Actin Affinities.
Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the Myosin motor.
Variable phenotypic expression and onset in MYH14 distal hereditary motor neuropathy phenotype in a large, multigenerational North American family.
Ventricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy.
[Molecular biology in cardiovascular medicine]
[Role of atrial myosin light chains in modulating the functional properties of myocardium]
[The human genome--chromosome 14]
Cardiomyopathy, Alcoholic
A comparative investigation into the effect of chronic alcohol feeding on the myocardium of normotensive and hypertensive rats: an electrophoretic and biochemical study.
Acetaldehyde and alcoholic cardiomyopathy: lessons from the ADH and ALDH2 transgenic models.
Autoantibodies against human ventricular myosin in sera of patients with acute and chronic myocarditis.
Cardiomyopathy, Dilated
A Complete Absence of Missense Mutation in Myosin Regulatory and Essential Light Chain Genes of South Indian Hypertrophic and Dilated Cardiomyopathies.
A troponin T variant linked with pediatric dilated cardiomyopathy reduces the coupling of thin filament activation to myosin and calcium binding.
Abnormal expression of histocompatibility and mitochondrial antigens by cardiac tissue from patients with myocarditis and dilated cardiomyopathy.
Adverse events in families with hypertrophic or dilated cardiomyopathy and mutations in the MYBPC3 gene.
Allele-Specific Silencing of Mutant Myh6 Transcripts in Mice Suppresses Hypertrophic Cardiomyopathy.
Altered expression of titin and contractile proteins in failing human myocardium.
Altered interactions between cardiac myosin binding protein-C and ?-cardiac actin variants associated with cardiomyopathies.
Analysis of structural proteins from biopsied human myocardium with special emphasis on methodology.
Antibodies against myosin in sera of patients with idiopathic paroxysmal atrial fibrillation.
Autoimmunity to alpha myosin in a subset of patients with idiopathic dilated cardiomyopathy.
Calcium sensitivity and myosin light chain pattern of atrial and ventricular skinned cardiac fibers from patients with various kinds of cardiac disease.
Cardiac autoantibodies in dilated cardiomyopathy become undetectable with disease progression.
Cardiac autoantibodies to myosin and other heart-specific autoantigens in myocarditis and dilated cardiomyopathy.
Cardiac myosin autoantibodies and acute rejection after heart transplantation in patients with dilated cardiomyopathy.
Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model.
Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function.
Cardiovascular gene expression profiles of dioxin exposure in zebrafish embryos.
Changes in essential myosin light chain isoform expression provide a molecular basis for isometric force regulation in the failing human heart.
Circulating levels of myocardial proteins predict future deterioration of congestive heart failure.
Clinical significance and pathogenic role of anti-cardiac myosin autoantibody in dilated cardiomyopathy.
Clinical significance of antibodies against tropomyosin, actin and myosin in patients with dilated cardiomyopathy.
cMyBP-C was decreased via KLHL3-mediated proteasomal degradation in congenital heart diseases.
Comparative effects of torasemide and furosemide on gap junction proteins and cardiac fibrosis in a rat model of dilated cardiomyopathy.
Congenital myopathies are mainly associated with a mild cardiac phenotype.
Consequences of unlocking the cardiac myosin molecule in human myocarditis and cardiomyopathies.
Converter domain mutations in myosin alter structural kinetics and motor function.
Coordinate changes in Myosin heavy chain isoform gene expression are selectively associated with alterations in dilated cardiomyopathy phenotype.
Coxsackievirus B3 induces T regulatory cells, which inhibit cardiomyopathy in tumor necrosis factor-alpha transgenic mice.
Development of dilated cardiomyopathy in Bmal1-deficient mice.
Digenic inheritance of mutations in the cardiac troponin (TNNT2) and cardiac beta myosin heavy chain (MYH7) as the cause of severe dilated cardiomyopathy.
Dilated cardiomyopathy mutation in the converter domain of human cardiac myosin alters motor activity and response to omecamtiv mecarbil.
Dilated cardiomyopathy myosin mutants have reduced force-generating capacity.
Disease mutations in striated muscle myosins.
Distribution of cardiac myosin isozymes in cardiomyopathy: immunohistochemical and gene analysis.
Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human ?-cardiac myosin.
Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes.
Elevated rates of force development and MgATP binding in F764L and S532P myosin mutations causing dilated cardiomyopathy.
Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector.
Establishing disease causality for a novel gene variant in familial dilated cardiomyopathy using a functional in-vitro assay of regulated thin filaments and human cardiac myosin.
Evaluation of 15 candidate genes for dilated cardiomyopathy in the Newfoundland dog.
Evidence for autoimmunity to myosin and other heart-specific autoantigens in patients with dilated cardiomyopathy and their relatives.
Expression of Normally Repressed Myosin Heavy Chain 7b in the Mammalian Heart Induces Dilated Cardiomyopathy.
Fatal Eosinophilic Myocarditis Develops in the Absence of IFN-? and IL-17A.
FR167653 suppresses the progression of experimental autoimmune myocarditis.
Heart failure-associated changes in RNA splicing of sarcomere genes.
Homozygous MYH7 R1820W mutation results in recessive myosin storage myopathy: Scapuloperoneal and respiratory weakness with dilated cardiomyopathy.
Human cardiac myosin autoantibodies impair myocyte contractility: a cause-and-effect relationship.
Human cardiac myosin light chains: sequence comparisons between myosin LC1 and LC2 from normal and idiopathic dilated cardiomyopathic hearts.
Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alpha-cardiac myosin in the laser trap assay.
Hypertrophic and Dilated Cardiomyopathy: Four Decades of Basic Research on Muscle Lead to Potential Therapeutic Approaches to These Devastating Genetic Diseases.
Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin.
Identification and validation of selective upregulation of ventricular myosin light chain type 2 mRNA in idiopathic dilated cardiomyopathy.
Identification of alpha- and beta-cardiac myosin heavy chain isoforms as major autoantigens in dilated cardiomyopathy.
Immunoglobulin G3 cardiac myosin autoantibodies correlate with left ventricular dysfunction in patients with dilated cardiomyopathy: immunoglobulin G3 and clinical correlates.
Immunopathogenesis of dilated cardiomyopathies.
Impact of pregnancy-related heart failure on humoral immunity: clinical relevance of G3-subclass immunoglobulins in peripartum cardiomyopathy.
Impaired muscle morphology in a Drosophila model of myosin storage myopathy was supressed by overexpression of an E3 ubiquitin ligase.
Increased myosin heavy chain-beta with atrial expression of ventricular light chain-2 in canine cardiomyopathy.
Interplay Between the Effects of Dilated Cardiomyopathy Mutation (R206L) and the Protein Kinase C Phosphomimic (T204E) of Rat Cardiac Troponin T Are Differently Modulated by ?- and ?-Myosin Heavy Chain Isoforms.
Lack of T cell response to cardiac myosin and a reduced response to PPD in patients with idiopathic dilated cardiomyopathy.
Laing early onset distal myopathy: slow myosin defect with variable abnormalities on muscle biopsy.
Light chain 2 profile and activity of human ventricular myosin during dilated cardiomyopathy. Identification of a causal agent for impaired myocardial function.
Liver-Specific siRNA-Mediated Stat3 or C3 Knockdown Improves the Outcome of Experimental Autoimmune Myocarditis.
Maximal actomyosin ATPase activity and in vitro myosin motility are unaltered in human mitral regurgitation heart failure.
Mutation screening in dilated cardiomyopathy: prominent role of the beta myosin heavy chain gene.
Myocarditis: Infection Versus Autoimmunity.
Myocarditogenic epitopes and autoimmune myocarditis.
Myofibrillar protein structure and assembly during idiopathic dilated cardiomyopathy.
Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation in Drosophila.
Myosin transducer mutations differentially affect motor function, myofibril structure, and the performance of skeletal and cardiac muscles.
Novel familial dilated cardiomyopathy mutation in MYL2 affects the structure and function of myosin regulatory light chain.
Omecamtiv Mecarbil, a Cardiac Myosin Activator, Increases Ca2+ Sensitivity in Myofilaments With a Dilated Cardiomyopathy Mutant Tropomyosin E54K.
Pathogenesis and therapy of autoimmunity-induced dilated cardiomyopathy.
Preclinical in vitro and in vivo pharmacokinetic properties of danicamtiv, a new targeted myosin activator for the treatment of dilated cardiomyopathy.
Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene.
Proteomics study on the effect of silybin on cardiomyopathy in obese mice.
Quercetin offers cardioprotection against progression of experimental autoimmune myocarditis by suppression of oxidative and endoplasmic reticulum stress via endothelin-1/MAPK signalling.
Sarcomere protein gene mutations and inherited heart disease: a beta-cardiac myosin heavy chain mutation causing endocardial fibroelastosis and heart failure.
Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modified
Selective requirement of myosin light chain 2v in embryonic heart function.
Spontaneous myocarditis mimicking human disease occurs in the presence of an appropriate MHC and non-MHC background in transgenic mice.
Subclass specificity of autoantibodies against myosin in patients with idiopathic dilated cardiomyopathy: pro-inflammatory antibodies in DCM patients.
The effect of intravenous immunoglobulins on the progression of experimental autoimmune myocarditis in the rat.
The genetic basis of pediatric cardiovascular disease.
The idiopathic dilated cardiomyopathy in man. A biochemical and molecular study on myosin.
The possible value of synthetic peptides in the diagnosis and therapy of myocarditis and dilated cardiomyopathy.
The UNC-45 Chaperone Is Critical for Establishing Myosin-Based Myofibrillar Organization and Cardiac Contractility in the Drosophila Heart Model.
Two-dimensional electrophoresis of heart muscle proteins in human cardiomyopathies.
Ventricular myosin light chain-2 gene expression in developing heart of chicken embryos.
Whole-exome sequencing reveals doubly novel heterozygous Myosin Binding Protein C and Titin mutations in a Chinese patient with severe dilated cardiomyopathy.
[ATP activity of myocardial actomyosin complex in patients with dilated cardiomyopathy]
[Autoantibodies against cardiac myosin in patients with myocarditis and dilated cardiomyopathy]
[Autoantibodies: new upstream targets of paroxysmal atrial fibrillation in patients with congestive heart failure]
[Changes in composition of cardiac myosin light chains in dilated cardiomyopathy: effect on functional properties]
[Changes in the composition of cardiac muscle myosin light chains during cardiac diseases].
[Clinical assessment of serum myosin light chain I in patients with dilated cardiomyopathy]
[Mutations genes in primarly cardiomyopathies].
[Role of atrial myosin light chains in modulating the functional properties of myocardium]
Cardiomyopathy, Hypertrophic
17-year follow-up study of a patient with obstructive hypertrophic cardiomyopathy with a deletion mutation in the cardiac myosin binding protein C gene.
?-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity.
?-Myosin heavy chain variant Val606Met causes very mild hypertrophic cardiomyopathy in mice, but exacerbates HCM phenotypes in mice carrying other HCM mutations.
A conserved negatively charged amino acid modulates function in human nonmuscle myosin IIA.
A Failure to Communicate: MYOSIN RESIDUES INVOLVED IN HYPERTROPHIC CARDIOMYOPATHY AFFECT INTER-DOMAIN INTERACTION.
A founder MYBPC3 mutation results in HCM with a high risk of sudden death after the fourth decade of life.
A Hypertrophic Cardiomyopathy-associated MYBPC3 Mutation Common in Populations of South Asian Descent Causes Contractile Dysfunction.
A missense mutation in the beta myosin heavy chain gene is a predictor of premature sudden death in patients with hypertrophic cardiomyopathy.
A molecular screening strategy based on beta-myosin heavy chain, cardiac myosin binding protein C and troponin T genes in Italian patients with hypertrophic cardiomyopathy.
A novel de novo mutation of ?-cardiac myosin heavy chain gene found in a twelve-year-old boy with hypertrophic cardiomyopathy.
A Novel Method of Determining the Functional Effects of a Minor Genetic Modification of a Protein.
A novel missense mutation in the myosin binding protein-C gene is responsible for hypertrophic cardiomyopathy with left ventricular dysfunction and dilation in elderly patients.
A novel Myosin essential light chain mutation causes hypertrophic cardiomyopathy with late onset and low expressivity.
A single serine in the carboxyl terminus of cardiac essential myosin light chain-1 controls cardiomyocyte contractility in vivo.
A small molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle.
A substitution mutation in the myosin binding protein C gene in ragdoll hypertrophic cardiomyopathy.
Ablation of cardiac myosin-binding protein-C accelerates stretch activation in murine skinned myocardium.
Ablation of the N terminus of cardiac essential light chain promotes the super-relaxed state of myosin and counteracts hypercontractility in hypertrophic cardiomyopathy mutant mice.
Abnormal blood pressure response to exercise occurs more frequently in hypertrophic cardiomyopathy patients with the R92W troponin T mutation than in those with myosin mutations.
Accumulation and assembly of myosin in hypertrophic cardiomyopathy with the 403 Arg to Gln beta-myosin heavy chain mutation.
Actin-associated proteins and cardiomyopathy-the 'unknown' beyond troponin and tropomyosin.
Adverse events in families with hypertrophic or dilated cardiomyopathy and mutations in the MYBPC3 gene.
Allele-Selective Knockdown of MYH7 Using Antisense Oligonucleotides.
Allele-Specific Silencing of Mutant Myh6 Transcripts in Mice Suppresses Hypertrophic Cardiomyopathy.
Allosteric effects of cardiac troponin TNT1 mutations on actomyosin binding: A novel pathogenic mechanism for hypertrophic cardiomyopathy.
Altered actin binding with myosin mutation in hypertrophic cardiomyopathy and sudden death.
Altered C10 domain in cardiac myosin binding protein-C results in hypertrophic cardiomyopathy.
Altered expression of early cardiac marker genes in circulating cells of patients with hypertrophic cardiomyopathy.
An Investigation of the Molecular Mechanism of Double cMyBP-C Mutation in a Patient with End-Stage Hypertrophic Cardiomyopathy.
Analysis of structural proteins from biopsied human myocardium with special emphasis on methodology.
Ascribing novel functions to the sarcomeric protein, myosin binding protein H (MyBPH) in cardiac sarcomere contraction.
Association of A31P and A74T Polymorphisms in the Myosin Binding Protein C3 Gene and Hypertrophic Cardiomyopathy in Maine Coon and Other Breed Cats.
Association of the myosin binding protein C3 mutation (MYBPC3 R820W) with cardiac death in a survey of 236 Ragdoll cats.
Beta myosin heavy chain mutations R403QLW, V606M, K615N and R663H in patients with hypertrophic cardiomyopathy.
Binding of myosin binding protein-C to myosin subfragment S2 affects contractility independent of a tether mechanism.
Biophysical properties of human ?-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy.
Blocking cardiac growth in hypertrophic cardiomyopathy induces cardiac dysfunction and decreased survival only in males.
C0 and C1 N-terminal Ig domains of myosin binding protein C exert different effects on thin filament activation.
Cardiac and skeletal actin substrates uniquely tune cardiac myosin strain-dependent mechanics.
Cardiac contractility, motor function, and cross-bridge kinetics in N47K-RLC mutant mice.
Cardiac myosin binding protein C insufficiency leads to early onset of mechanical dysfunction.
Cardiac Myosin Binding Protein-C Mutations in Families with Hypertrophic Cardiomyopathy: Disease Expression in Relation to Age, Gender, and Long Term Outcome.
Cardiac myosin binding protein-C variants in paediatric-onset hypertrophic cardiomyopathy: natural history and clinical outcomes.
Cardiac myosin heavy chains lacking the light chain binding domain cause hypertrophic cardiomyopathy in mice.
Cardiac myosin light chain-2: a novel essential component of thick-myofilament assembly and contractility of the heart.
Cardiac myosin super relaxation (SRX): a perspective on fundamental biology, human disease and therapeutics.
Cardiomyopathy mutations reveal variable region of myosin converter as major element of cross-bridge compliance.
Characteristics and prognostic implications of myosin missense mutations in familial hypertrophic cardiomyopathy.
Characteristics of the beta myosin heavy chain gene Ala26Val mutation in a Chinese family with hypertrophic cardiomyopathy.
Clinical Utility of a Phenotype Enhanced MYH7-Specific Variant Classification Framework in Hypertrophic Cardiomyopathy Genetic Testing.
cMyBP-C was decreased via KLHL3-mediated proteasomal degradation in congenital heart diseases.
Coexistence of mitochondrial DNA and beta myosin heavy chain mutations in hypertrophic cardiomyopathy with late congestive heart failure.
Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice.
Contractile protein mutations and heart disease.
Contractility parameters of human ?-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function.
Correction to: Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy.
Crystal structure of the C1 domain of cardiac myosin binding protein-C: implications for hypertrophic cardiomyopathy.
Depletion of zebrafish essential and regulatory myosin light chains reduces cardiac function through distinct mechanisms.
Development of induced pluripotent stem cells from a patient with hypertrophic cardiomyopathy who carries the pathogenic myosin heavy chain 7 mutation p.Arg403Gln.
Differential methylation of CpG sites in two isoforms of myosin binding protein C, an important hypertrophic cardiomyopathy gene.
Direct detection of the myosin super-relaxed state and interacting-heads motif in solution.
Disease mutations in striated muscle myosins.
Double heterozygosity for mutations in the beta-myosin heavy chain and in the cardiac myosin binding protein C genes in a family with hypertrophic cardiomyopathy.
E258K HCM-causing mutation in cardiac MyBP-C reduces contractile force and accelerates twitch kinetics by disrupting the cMyBP-C and myosin S2 interaction.
Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human ?-Cardiac Myosin.
Effects of MYBPC3 loss-of-function mutations preceding hypertrophic cardiomyopathy.
Electromyographic evidence of subclinical myopathy in hypertrophic cardiomyopathy.
Emerging pharmacologic and structural therapies for hypertrophic cardiomyopathy.
Exclusion of cardiac myosin heavy chain and actin gene involvement in hypertrophic cardiomyopathy of several French families.
Expression of atrial myosin light chains but not alpha-myosin heavy chains is correlated in vivo with increased ventricular function in patients with hypertrophic obstructive cardiomyopathy.
Familial hypertrophic cardiomyopathy mutations in the regulatory light chains of myosin affect their structure, Ca2+ binding, and phosphorylation.
Functional characterization of the human atrial essential myosin light chain (hALC-1) in a transgenic rat model.
Gene expression patterns in transgenic mouse models of hypertrophic cardiomyopathy caused by mutations in myosin regulatory light chain.
Generation of an induced pluripotent stem cell line from a hypertrophic cardiomyopathy patient with a pathogenic myosin binding protein C (MYBPC3) p.Arg502Trp mutation.
Generation of an induced pluripotential stem cell (iPSC) line from a patient with hypertrophic cardiomyopathy carrying myosin binding protein C (MYBPC3) c.3369-3370 insC mutation.
Genetic Dissection of Hypertrophic Cardiomyopathy with Myocardial RNA-Seq.
Genetic polymorphisms in the renin-angiotensin-aldosterone system associated with expression of left ventricular hypertrophy in hypertrophic cardiomyopathy: a study of five polymorphic genes in a family with a disease causing mutation in the myosin binding protein C gene.
Genetic testing for risk stratification in hypertrophic cardiomyopathy and long QT syndrome: fact or fiction?
Genotype-phenotype correlation between the cardiac myosin binding protein C mutation A31P and hypertrophic cardiomyopathy in a cohort of Maine Coon cats: a longitudinal study.
Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice.
Heat shock proteins and small nucleolar RNAs are dysregulated in a Drosophila model for feline hypertrophic cardiomyopathy.
Heterologous expression of a cardiomyopathic myosin that is defective in its actin interaction.
HSC70 is a chaperone for wild-type and mutant cardiac myosin binding protein C.
Human atrial myosin light chain 1 expression attenuates heart failure.
Hypertrophic cardiomyopathy ?-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state.
Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light.
Hypertrophic cardiomyopathy associated E22K mutation in myosin regulatory light chain decreases calcium-activated tension and stiffness and reduces myofilament Ca2+ sensitivity.
Hypertrophic cardiomyopathy associated Lys104Glu mutation in the myosin regulatory light chain causes diastolic disturbance in mice.
Hypertrophic cardiomyopathy caused by a novel alpha-tropomyosin mutation (V95A) is associated with mild cardiac phenotype, abnormal calcium binding to troponin, abnormal myosin cycling, and poor prognosis.
Hypertrophic cardiomyopathy disease results from disparate impairments of cardiac myosin function and auto-inhibition.
Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice.
Hypertrophic cardiomyopathy in young Maine Coon cats caused by the p.A31P cMyBP-C mutation--the clinical significance of having the mutation.
Hypertrophic cardiomyopathy mutation R58Q in the myosin regulatory light chain perturbs thick filament-based regulation in cardiac muscle.
Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin.
Hypertrophic cardiomyopathy-related beta-myosin mutations cause highly variable calcium sensitivity with functional imbalances among individual muscle cells.
Hypertrophic cardiomyopathy: an update.
Hypertrophic cardiomyopathy: failure to demonstrate mutations in exon 13 of the cardiac beta myosin heavy-chain gene.
Identification of a mutation in the beta cardiac myosin heavy chain gene in a family with hypertrophic cardiomyopathy.
Identification of a mutation near a functional site of the beta cardiac myosin heavy chain gene in a family with hypertrophic cardiomyopathy.
Identification of an Arg403Gln beta myosin heavy chain gene mutation in a Portuguese family with hypertrophic cardiomyopathy.
Identification of novel interactions between domains of Myosin binding protein-C that are modulated by hypertrophic cardiomyopathy missense mutations.
Identification of two novel mutations in the ventricular regulatory myosin light chain gene (MYL2) associated with familial and classical forms of hypertrophic cardiomyopathy.
Impact of the Myosin Modulator Mavacamten on Force Generation and Cross-Bridge Behavior in a Murine Model of Hypercontractility.
In vitro and in vivo pharmacokinetic characterization of mavacamten, a first-in-class small molecule allosteric modulator of beta cardiac myosin.
In vivo cardiac Myosin binding protein C gene transfer rescues myofilament contractile dysfunction in cardiac Myosin binding protein C null mice.
Independent origin of identical beta cardiac myosin heavy-chain mutations in hypertrophic cardiomyopathy.
Insights into human beta-cardiac myosin function from single molecule and single cell studies.
Interaction of F-actin with synthetic peptides spanning the loop region of human cardiac beta-myosin heavy chain containing Arg403.
Isometric tension and mutant myosin heavy chain content in single skeletal myofibers from hypertrophic cardiomyopathy patients.
M-class hypertrophic cardiomyopathy cardiac actin mutations increase calcium sensitivity of regulated thin filaments.
Malalignment of the sarcomeric filaments in hypertrophic cardiomyopathy with cardiac myosin heavy chain gene mutation.
Male sex aggravates the phenotype in mouse models of hypertrophic cardiomyopathy.
Mavacamten decreases maximal force and Ca2+ sensitivity in the N47K-myosin regulatory light chain mouse model of hypertrophic cardiomyopathy.
Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial.
Mavacamten preserves length-dependent contractility and improves diastolic function in human engineered heart tissue.
Mavacamten rescues increased myofilament calcium sensitivity and dysregulation of Ca2+ flux caused by thin filament hypertrophic cardiomyopathy mutations.
Mavacamten stabilizes an autoinhibited state of two-headed cardiac myosin.
Mavacamten Treatment for Obstructive Hypertrophic Cardiomyopathy: A Clinical Trial.
Mavacamten: a novel small molecule modulator of ?-cardiac myosin for treatment of hypertrophic cardiomyopathy.
Micro-exons of the cardiac myosin binding protein C gene: flanking introns contain a disproportionately large number of hypertrophic cardiomyopathy mutations.
Microsatellite marker analysis in the treatment and diagnosis of familial hypertrophic cardiomyopathy.
Missense mutation of the beta-cardiac myosin heavy-chain gene in hypertrophic cardiomyopathy.
Modulating myosin function to treat hypertrophic cardiomyopathy.
Modulation of cardiac performance by motor protein gene transfer.
Molecular basis of hypertrophic and dilated cardiomyopathy.
Molecular biology of human muscle disease.
Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human ?-cardiac myosin motor function.
Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C.
Molecular genetics of hypertrophic cardiomyopathy.
Multidimensional structure-function relationships in human ?-cardiac myosin from population-scale genetic variation.
Mutation of V896M in cardiac myosin binding protein-c gene in two Chinese families with hypertrophic cardiomyopathy.
Mutation that causes hypertrophic cardiomyopathy increases force production in human ?-cardiac myosin.
Mutations in myosin S2 alter cardiac myosin-binding protein-C interaction in hypertrophic cardiomyopathy in a phosphorylation-dependent manner.
Mutations in the motor domain modulate myosin activity and myofibril organization.
Mutations of the beta myosin heavy chain gene in hypertrophic cardiomyopathy: critical functional sites determine prognosis.
Mutations of ventricular essential myosin light chain disturb myosin binding and sarcomeric sorting.
MyBP-C: one protein to govern them all.
MYBPC3 truncation mutations enhance actomyosin contractile mechanics in human hypertrophic cardiomyopathy.
MYH7-related disorders in two Bulgarian families: Novel variants in the same region associated with different clinical manifestation and disease penetrance.
MYH7-related myopathies: clinical, histopathological and imaging findings in a cohort of Italian patients.
Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C.
Myosin binding protein C (MYBPC) and hypertrophic cardiomyopathy: role of altered C10 domain.
Myosin binding protein C mutations and compound heterozygosity in hypertrophic cardiomyopathy.
Myosin binding protein C phosphorylation in normal, hypertrophic and failing human heart muscle.
Myosin Modulation in Hypertrophic Cardiomyopathy and Systolic Heart Failure: Getting Inside the Engine.
Myosin Modulators: The New Era of Medical Therapy for Systolic Heart Failure and Hypertrophic Cardiomyopathy.
Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties.
Myosin mutations in hypertrophic cardiomyopathy and functional implications.
Myosin regulatory light chain mutation found in hypertrophic cardiomyopathy patients increases isometric force production in transgenic mice.
Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy.
Myosin VI Is a Mediator of the p53-Dependent Cell Survival Pathway.
Myosins: Domain Organisation, Motor Properties, Physiological Roles and Cellular Functions.
Nanomechanical Phenotypes in Cardiac Myosin-Binding Protein C Mutants That Cause Hypertrophic Cardiomyopathy.
Naturally Occurring Biventricular Noncompaction in an Adult Domestic Cat.
New cardiac and skeletal protein aggregate myopathy associated with combined MuRF1 and MuRF3 mutations.
Novel association of hypertrophic cardiomyopathy, sensorineural deafness, and a mutation in unconventional myosin VI (MYO6).
Novel missense mutation in cardiac beta myosin heavy chain gene found in a Japanese patient with hypertrophic cardiomyopathy.
Phosphomimetic cardiac myosin-binding protein C partially rescues a cardiomyopathy phenotype in murine engineered heart tissue.
Phosphomimetic-mediated in vitro rescue of hypertrophic cardiomyopathy linked to R58Q mutation in myosin regulatory light chain.
Point mutations in human beta cardiac myosin heavy chain have differential effects on sarcomeric structure and assembly: an ATP binding site change disrupts both thick and thin filaments, whereas hypertrophic cardiomyopathy mutations display normal assembly.
Preserved cross-bridge kinetics in human hypertrophic cardiomyopathy patients with MYBPC3 mutations.
Pressure Overload Is Associated With Low Levels of Troponin I and Myosin Binding Protein C Phosphorylation in the Hearts of Patients With Aortic Stenosis.
Prolonged cross-bridge binding triggers muscle dysfunction in a Drosophila model of myosin-based hypertrophic cardiomyopathy.
Protein-protein interactions in actin-myosin binding and structural effects of R405Q mutation: a molecular dynamics study.
Proteomics study on the effect of silybin on cardiomyopathy in obese mice.
Re: Association of A31P and A74T polymorphisms in the myosin binding protein C3 gene and hypertrophic cardiomyopathy in Maine Coon and other breed cats.
Relationship between myosin isoenzyme composition, hemodynamics, and myocardial structure in various forms of human cardiac hypertrophy.
Research progress of myosin heavy chain genes in human genetic diseases.
Resolving myoarchitectural disarray in the mouse ventricular wall with diffusion spectrum magnetic resonance imaging.
Review: Metabolic cardiomyopathy and conduction system defects in children.
Role of common sarcomeric gene polymorphisms in genetic susceptibility to left ventricular dysfunction.
Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly.
Screening mutations in myosin binding protein C3 gene in a cohort of patients with Hypertrophic Cardiomyopathy.
Selected mutations in the myosin binding protein C gene in the Polish population of patients with hypertrophic cardiomyopathy.
Skeletal muscle expression and abnormal function of beta-myosin in hypertrophic cardiomyopathy.
Slow Cardiac Myosin Regulatory Light Chain 2 (MYL2) was Down-Expressed in Chronic Heart Failure Patients.
Slow cardiac myosin regulatory light chain 2 (MYL2) was down-expressed in chronic heart failure patients.
Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain.
Sporadic hypertrophic cardiomyopathy due to de novo myosin mutations.
Structure-function relationships in myosin binding protein-C: taking off the blinders and collaring hypertrophic cardiomyopathy.
Symptomatic distal myopathy with cardiomyopathy due to a MYH7 mutation.
Synthetic thick filaments: A new avenue for better understanding the myosin super-relaxed state in healthy, disease, and mavacamten-treated cardiac systems.
Synthetic thick filaments: A new avenue for better understanding the myosin super-relaxed state in healthy, diseased, and mavacamten-treated cardiac systems.
Systematic analysis of the regulatory and essential myosin light chain genes: genetic variants and mutations in hypertrophic cardiomyopathy.
The A31P missense mutation in cardiac myosin binding protein C alters protein structure but does not cause haploinsufficiency.
The Cardiac Myosin Binding Protein C Arg502Trp Mutation. A Common Cause of Hypertrophic Cardiomyopathy.
The cardiac myosin heavy chain Arg-403-->Gln mutation that causes hypertrophic cardiomyopathy does not affect the actin- or ATP-binding capacities of two size-limited recombinant myosin heavy chain fragments.
The cMyBP-C HCM variant L348P enhances thin filament activation through an increased shift in tropomyosin position.
The electrocardiogram is a more sensitive indicator than echocardiography of hypertrophic cardiomyopathy in families with a mutation in the MYH7 gene.
The genetic basis of pediatric cardiovascular disease.
The HCM-causing Y235S cMyBPC mutation accelerates contractile function by altering C1 domain structure.
The HCM-linked W792R mutation in cardiac myosin binding protein-C reduces C6 FnIII domain stability.
The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin.
The hypertrophic cardiomyopathy myosin mutation R453C alters ATP binding and hydrolysis of human cardiac ?-myosin.
The in vitro motility activity of beta-cardiac myosin depends on the nature of the beta-myosin heavy chain gene mutation in hypertrophic cardiomyopathy.
The left and right ventricle of a patient with a R723G mutation of the beta-myosin heavy chain and severe hypertrophic cardiomyopathy show no differences in the expression of myosin mRNA.
The molecular biology and pathophysiology of hypertrophic cardiomyopathy due to mutations in the beta myosin heavy chains and the essential and regulatory light chains.
The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy.
The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy.
The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations.
The R249Q hypertrophic cardiomyopathy myosin mutation decreases contractility in Drosophila by impeding force production.
Thick Filament Mechano-Sensing in Skeletal and Cardiac Muscles: A Common Mechanism Able to Adapt the Energetic Cost of the Contraction to the Task.
Three perspectives on the molecular basis of hypercontractility caused by hypertrophic cardiomyopathy mutations.
Three-dimensional structure of the human myosin thick filament: clinical implications.
Tuning the human heart molecular motors by myosin light chains.
Unexpectedly low mutation rates in beta-myosin heavy chain and cardiac myosin binding protein genes in italian patients with hypertrophic cardiomyopathy.
Variable cardiac myosin binding protein-C expression in the myofilaments due to MYBPC3 mutations in hypertrophic cardiomyopathy.
Whole exome sequencing combined with integrated variant annotation prediction identifies a causative myosin essential light chain variant in hypertrophic cardiomyopathy.
[A novel hot-spot mutation S236G in the cardiac myosin binding protein C gene in Chinese patient with hypertrophic cardiomyopathy]
[Clinical and molecular genetics of hypertrophic cardiomyopathy]
[Genetics of hereditary cardiopathies]
[Link between cardiac myosin binding protein-C gene mutation of Pro1208fs and Gly507 Arg and hypertrophic cardiomyopathy in Chinese patients]
[Molecular genetics of cardiovascular diseases]
[Mutation analysis of beta myosin heavy chain gene in hypertrophic cardiomyopathy families].
[Mutations genes in primarly cardiomyopathies].
[Novel Val606Met mutation in beta myosin heavy chain gene in Chinese pedigrees with familiar hypertrophic cardiomyopathy]
[P1208fs mutation in the cardiac myosin binding protein C is associated with hypertrophic cardiomyopathy in a Chinese pedigree].
[Research of markers for the genes of the heavy chain of cardiac beta-myosin and myosin binding protein C in relatives of patients with hypertrophic cardiomyopathy.]
Cardiomyopathy, Hypertrophic, Familial
A cardiac myosin binding protein C mutation in the Maine Coon cat with familial hypertrophic cardiomyopathy.
A disease locus for familial hypertrophic cardiomyopathy maps to chromosome 1q3.
A familial hypertrophic cardiomyopathy alpha-tropomyosin mutation causes severe cardiac hypertrophy and death in mice.
A locus for familial hypertrophic cardiomyopathy is closely linked to the cardiac myosin heavy chain genes, CRI-L436, and CRI-L329 on chromosome 14 at q11-q12.
A molecular basis for familial hypertrophic cardiomyopathy: a beta cardiac myosin heavy chain gene missense mutation.
A molecular basis for familial hypertrophic cardiomyopathy: an alpha/beta cardiac myosin heavy chain hybrid gene.
A mouse model of familial hypertrophic cardiomyopathy.
A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy.
A myosin missense mutation, not a null allele, causes familial hypertrophic cardiomyopathy.
A new missense mutation, Arg719Gln, in the beta-cardiac heavy chain myosin gene of patients with familial hypertrophic cardiomyopathy.
A novel mutation of the beta myosin heavy chain gene responsible for familial hypertrophic cardiomyopathy.
A p.R870H mutation in the beta-cardiac myosin heavy chain 7 gene causes familial hypertrophic cardiomyopathy in several members of an Indian family.
A previously undescribed de novo insertion-deletion mutation in the beta myosin heavy chain gene in a kindred with familial hypertrophic cardiomyopathy.
A trinucleotide repeat combination polymorphism in the cardiac alpha myosin heavy chain (MYH6) gene.
A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy.
Allelic imbalance and haploinsufficiency in MYBPC3-linked hypertrophic cardiomyopathy.
Altered cardiac troponin T in vitro function in the presence of a mutation implicated in familial hypertrophic cardiomyopathy.
Altered interactions among thin filament proteins modulate cardiac function.
An alpha-cardiac myosin heavy chain gene mutation impairs contraction and relaxation function of cardiac myocytes.
An evaluation of ribonuclease protection assays for the detection of beta-cardiac myosin heavy chain gene mutations.
cAPK-phosphorylation controls the interaction of the regulatory domain of cardiac myosin binding protein C with myosin-S2 in an on-off fashion.
Cardiac myosin binding protein C phosphorylation in cardiac disease.
Cardiac myosin binding protein-C gene splice acceptor site mutation is associated with familial hypertrophic cardiomyopathy.
Cardiac myosin heavy chains lacking the light chain binding domain cause hypertrophic cardiomyopathy in mice.
Cardiomyopathy-linked myosin regulatory light chain mutations disrupt myosin strain-dependent biochemistry.
Cardiomyopathy: molecular and immunological aspects (review).
Cardiovascular molecular genetics.
Cell-intrinsic functional effects of the ?-cardiac myosin Arg-403-Gln mutation in familial hypertrophic cardiomyopathy.
Characteristics and prognostic implications of myosin missense mutations in familial hypertrophic cardiomyopathy.
Characterization of mutant myosins of Dictyostelium discoideum equivalent to human familial hypertrophic cardiomyopathy mutants. Molecular force level of mutant myosins may have a prognostic implication.
Clinical and prognostic evaluation of familial hypertrophic cardiomyopathy in two South African families with different cardiac beta myosin heavy chain gene mutations.
Clinical features and prognostic implications of familial hypertrophic cardiomyopathy related to the cardiac myosin-binding protein C gene.
Comparison of two murine models of familial hypertrophic cardiomyopathy.
Computational analysis of folding and mutation properties of C5 domain of myosin binding protein C.
Cross-bridge kinetics in myofibrils containing familial hypertrophic cardiomyopathy R58Q mutation in the regulatory light chain of myosin.
Data on whole length myosin binding protein C stabilizes myosin S2 as measured by gravitational force spectroscopy.
Deletion of the myopathy loop of Dictyostelium myosin II and its impact on motor functions.
Diastolic dysfunction and altered energetics in the alphaMHC403/+ mouse model of familial hypertrophic cardiomyopathy.
Diastolic dysfunction in familial hypertrophic cardiomyopathy transgenic model mice.
Different expressivity of a ventricular essential myosin light chain gene Ala57Gly mutation in familial hypertrophic cardiomyopathy.
Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium.
Discrete effects of A57G-myosin essential light chain mutation associated with familial hypertrophic cardiomyopathy.
Diversity and similarity of motor function and cross-bridge kinetics in papillary muscles of transgenic mice carrying myosin regulatory light chain mutations D166V and R58Q.
Early expression of a malignant phenotype of familial hypertrophic cardiomyopathy associated with a Gly716Arg myosin heavy chain mutation in a Korean family.
Early remodeling of repolarizing K(+) currents in the ?MHC(403/+) mouse model of familial hypertrophic cardiomyopathy.
Effects of R92 mutations in mouse cardiac troponin T are influenced by changes in myosin heavy chain isoform.
Enhanced myosin function due to a point mutation causing a familial hypertrophic cardiomyopathy.
Familial hypertrophic cardiomyopathy and atrial fibrillation caused by Arg663His beta-cardiac myosin heavy chain mutation.
Familial hypertrophic cardiomyopathy can be characterized by a specific pattern of orientation fluctuations of actin molecules .
Familial hypertrophic cardiomyopathy mutations in the regulatory light chains of myosin affect their structure, Ca2+ binding, and phosphorylation.
Familial hypertrophic cardiomyopathy: from mutations to functional defects.
Familial hypertrophic cardiomyopathy: Functional effects of myosin mutation R723G in cardiomyocytes.
Fluorescence Lifetime of Actin in the Familial Hypertrophic Cardiomyopathy Transgenic Heart (dagger).
Functional analysis of myosin missense mutations in familial hypertrophic cardiomyopathy.
Functional analysis of myosin mutations that cause familial hypertrophic cardiomyopathy.
Functional analysis of the mutations in the human cardiac beta-myosin that are responsible for familial hypertrophic cardiomyopathy. Implication for the clinical outcome.
Functional and spectroscopic studies of a familial hypertrophic cardiomyopathy mutation in Motif X of cardiac myosin binding protein-C.
Functional consequences of mutations in the myosin heavy chain at sites implicated in familial hypertrophic cardiomyopathy.
Functional consequences of mutations in the smooth muscle myosin heavy chain at sites implicated in familial hypertrophic cardiomyopathy.
Functional studies of individual myosin molecules.
Gender and aging in a transgenic mouse model of hypertrophic cardiomyopathy.
Genetic variant affecting the myosin light chain 2 related to familial hypertrophic cardiomyopathy.
Genotype-phenotype correlations in familial hypertrophic cardiomyopathy. A comparison between mutations in the cardiac protein-C and the beta-myosin heavy chain genes.
Heterologous expression of wild-type and mutant beta-cardiac myosin changes the contractile kinetics of cultured mouse myotubes.
Hypertrophic cardiomyopathy associated Lys104Glu mutation in the myosin regulatory light chain causes diastolic disturbance in mice.
Hypothesis and theory: mechanical instabilities and non-uniformities in hereditary sarcomere myopathies.
Identification of a mutation near a functional site of the beta cardiac myosin heavy chain gene in a family with hypertrophic cardiomyopathy.
Identification of novel protein kinase A phosphorylation sites in the M-domain of human and murine cardiac myosin binding protein-C using mass spectrometry analysis.
Identification of two novel mutations in the ventricular regulatory myosin light chain gene (MYL2) associated with familial and classical forms of hypertrophic cardiomyopathy.
Impact of familial hypertrophic cardiomyopathy-linked mutations in the NH2 terminus of the RLC on ?-myosin cross-bridge mechanics.
Impaired contractile function due to decreased cardiac myosin binding protein C content in the sarcomere.
Impairment of the ubiquitin-proteasome system by truncated cardiac myosin binding protein C mutants.
In vitro rescue study of a malignant familial hypertrophic cardiomyopathy phenotype by pseudo-phosphorylation of myosin regulatory light chain.
In vivo analysis of an essential myosin light chain mutation linked to familial hypertrophic cardiomyopathy.
In vivo modeling of myosin binding protein C familial hypertrophic cardiomyopathy.
Inclusion body myositis coexisting with hypertrophic cardiomyopathy: an autopsy study.
Independent origin of identical beta cardiac myosin heavy-chain mutations in hypertrophic cardiomyopathy.
Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein.
Isoform transitions of the myosin binding protein C family in developing human and mouse muscles: lack of isoform transcomplementation in cardiac muscle.
Lack of evidence of exon 13 mutations in the beta cardiac myosin heavy chain gene with familial hypertrophic cardiomyopathy in Japan.
Laing early onset distal myopathy: slow myosin defect with variable abnormalities on muscle biopsy.
Low sequence variation in the gene encoding the human beta-myosin heavy chain.
Malignant familial hypertrophic cardiomyopathy D166V mutation in the ventricular myosin regulatory light chain causes profound effects in skinned and intact papillary muscle fibers from transgenic mice.
Malignant familial hypertrophic cardiomyopathy in a family with a 453Arg-->Cys mutation in the beta-myosin heavy chain gene: coexistence of sudden death and end-stage heart failure.
Mechanical defects of muscle fibers with myosin light chain mutants that cause cardiomyopathy.
Mice expressing mutant myosin heavy chains are a model for familial hypertrophic cardiomyopathy.
Missense mutation of the beta-cardiac myosin heavy-chain gene in hypertrophic cardiomyopathy.
Missing pieces: myosin binding protein C truncations in familial hypertrophic cardiomyopathy.
Molecular pathology of familial hypertrophic cardiomyopathy caused by mutations in the cardiac myosin binding protein C gene.
Mutation of the myosin converter domain alters cross-bridge elasticity.
Mutations in cardiac myosin heavy chain genes cause familial hypertrophic cardiomyopathy.
Mutations in the cardiac myosin binding protein-C gene on chromosome 11 cause familial hypertrophic cardiomyopathy.
Mutations in the genes for cardiac troponin T and alpha-tropomyosin in hypertrophic cardiomyopathy.
Mutations in the motor domain modulate myosin activity and myofibril organization.
Myosin binding protein C, a phosphorylation-dependent force regulator in muscle that controls the attachment of myosin heads by its interaction with myosin S2.
Myosin binding protein C: structural abnormalities in familial hypertrophic cardiomyopathy.
Myosin cross-bridges do not form precise rigor bonds in hypertrophic heart muscle carrying troponin t mutations.
Myosin filament 3D structure in mammalian cardiac muscle.
Myosin light chain mutations in familial hypertrophic cardiomyopathy: phenotypic presentation and frequency in Danish and South African populations.
Myosin regulatory light chain E22K mutation results in decreased cardiac intracellular calcium and force transients.
Myosins and pathology: genetics and biology.
N232S, G741R and D778G beta-cardiac myosin mutants, implicated in familial hypertrophic cardiomyopathy, do not disrupt myofibrillar organisation in cultured myotubes.
Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene.
Organization and sequence of human cardiac myosin binding protein C gene (MYBPC3) and identification of mutations predicted to produce truncated proteins in familial hypertrophic cardiomyopathy.
Phenotypic deficits in mice expressing a myosin binding protein C lacking the titin and myosin binding domains.
Phosphorylation of human cardiac troponin I G203S and K206Q linked to familial hypertrophic cardiomyopathy affects actomyosin interaction in different ways.
Possible gene dose effect of a mutant cardiac beta-myosin heavy chain gene on the clinical expression of familial hypertrophic cardiomyopathy.
Preclinical diagnosis of familial hypertrophic cardiomyopathy by genetic analysis of blood lymphocytes.
Prognostic implications of novel beta cardiac myosin heavy chain gene mutations that cause familial hypertrophic cardiomyopathy.
Prolonged Ca2+ and force transients in myosin RLC transgenic mouse fibers expressing malignant and benign FHC mutations.
R403Q and L908V mutant beta-cardiac myosin from patients with familial hypertrophic cardiomyopathy exhibit enhanced mechanical performance at the single molecule level.
Relation between QT duration and maximal wall thickness in familial hypertrophic cardiomyopathy.
Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy.
Sarcomere protein gene mutations in hypertrophic cardiomyopathy of the elderly.
Single molecule detection approach to muscle study: kinetics of a single cross-bridge during contraction of muscle.
Single molecule kinetics in the familial hypertrophic cardiomyopathy D166V mutant mouse heart.
Single-molecule mechanics of R403Q cardiac myosin isolated from the mouse model of familial hypertrophic cardiomyopathy.
Species-specific differences in the Pro-Ala rich region of cardiac myosin binding protein-C.
Sporadic hypertrophic cardiomyopathy due to de novo myosin mutations.
Stability and kinetic properties of C5-domain from myosin binding protein C and its mutants.
Structural interpretation of the mutations in the beta-cardiac myosin that have been implicated in familial hypertrophic cardiomyopathy.
The 3-state model of muscle regulation revisited: is a fourth state involved?
The cardiac myosin heavy chain Arg-403-->Gln mutation that causes hypertrophic cardiomyopathy does not affect the actin- or ATP-binding capacities of two size-limited recombinant myosin heavy chain fragments.
The E22K mutation of myosin RLC that causes familial hypertrophic cardiomyopathy increases calcium sensitivity of force and ATPase in transgenic mice.
The molecular and cellular biology of heart failure.
The pathogenesis of familial hypertrophic cardiomyopathy: early and evolving effects from an alpha-cardiac myosin heavy chain missense mutation.
The R403Q Myosin Mutation Implicated in Familial Hypertrophic Cardiomyopathy Causes Disorder at the Actomyosin Interface.
The structure of isolated cardiac Myosin thick filaments from cardiac Myosin binding protein-C knockout mice.
The two heads of smooth muscle myosin are enzymatically independent but mechanically interactive.
Tissue Doppler imaging in Maine Coon cats with a mutation of myosin binding protein C with or without hypertrophy.
Variability in the ratio of mutant to wildtype myosin heavy chain present in the soleus muscle of patients with familial hypertrophic cardiomyopathy. A new approach for the quantification of mutant to wildtype protein.
Zebrafish cardiac muscle thick filaments: isolation technique and three-dimensional structure.
[Cardiac contractile proteins]
[Genetic heterogeneity of myosin heavy chain 7 gene G823E mutation in familial hypertrophic cardiomyopathy in Chinese]
[Molecular biology in cardiovascular medicine]
[Molecular genetics of cardiovascular diseases]
[Mutations in beta myosin heavy chain gene: two mutations in Chinese with familial hypertrophic cardiomyopathy and the correlation between the genotype and phenotype]
[Structural analysis of cardiac beta myosin heavy chain gene in familial hypertrophic cardiomyopathy]
[The Val606Met mutation of human beta myosin heavy chain in a Chinese familial hypertrophic cardiomyopathy family]
Cardiomyopathy, Restrictive
A de novo mutation of the beta cardiac myosin heavy chain gene in an infantile restrictive cardiomyopathy.
A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila.
Allele-Specific Silencing Ameliorates Restrictive Cardiomyopathy Attributable to a Human Myosin Regulatory Light Chain Mutation.
Hypercontractile mutant of ventricular myosin essential light chain leads to disruption of sarcomeric structure and function and results in restrictive cardiomyopathy in mice.
Mutations in human cardiac troponin I that are associated with restrictive cardiomyopathy affect basal ATPase activity and the calcium sensitivity of force development.
Myosin transducer mutations differentially affect motor function, myofibril structure, and the performance of skeletal and cardiac muscles.
Cardiotoxicity
Administration of chromium(III) and manganese(II) as a potential protective approach against daunorubicin-induced cardiotoxicity: in vitro and in vivo experimental evidence.
Biological activity of cordifene: on myosin: a model for conjugated alpha-methylene ketone group's cardiac toxicity.
Biomarker panel of cardiac and skeletal muscle troponins, fatty acid binding protein 3 and myosin light chain 3 for the accurate diagnosis of cardiotoxicity and musculoskeletal toxicity in rats.
Candesartan cilexetil protects from cardiac myosin induced cardiotoxicity via reduction of endoplasmic reticulum stress and apoptosis in rats: involvement of ACE2-Ang (1-7)-mas axis.
Determination of light-chain myosin in pregnancy and under tocolysis.
Dexrazoxane pre-treatment protects skinned rat cardiac trabeculae against delayed doxorubicin-induced impairment of crossbridge kinetics.
Doxorubicin induces detrusor smooth muscle impairments through myosin dysregulation, leading to a risk of lower urinary tract dysfunction.
Doxorubicin-induced carbonylation and degradation of cardiac myosin binding protein C promote cardiotoxicity.
Exercise preconditioning protects against doxorubicin-induced cardiac dysfunction.
Fluorescence spectra of cardiac myosin and in vivo experiment: studies on daunorubicin-induced cardiotoxicity.
The effects of N-acetylcysteine on cisplatin induced cardiotoxicity.
Voluntary wheel running in rats receiving doxorubicin: effects on running activity and cardiac myosin heavy chain.
Cardiovascular Abnormalities
Molecular aspects of cardiac hypertrophy.
Cardiovascular Diseases
Cardiac myosin super relaxation (SRX): a perspective on fundamental biology, human disease and therapeutics.
Expression of the beta (slow)-isoform of MHC in the adult mouse heart causes dominant-negative functional effects.
Humoral immune response against contractile proteins (actin and myosin) during cardiovascular disease.
Inhibition of myosin IIA-actin interaction prevents ischemia/reperfusion induced cardiomyocytes apoptosis through modulating PINK1/Parkin pathway and mitochondrial fission.
Measurement of Rho-associated kinase (ROCK) activity in humans: Validity of leukocyte p-MBS/t-MBS in comparison with vascular response to fasudil.
Proteomic analysis of right and left cardiac ventricles under aerobic conditions and after ischemia/reperfusion.
SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells.
[Molecular genetics of cardiovascular diseases]
Carney Complex
Clinical phenotypes and molecular genetic mechanisms of Carney complex.
Mutation of perinatal myosin heavy chain associated with a Carney complex variant.
Carotid Artery Diseases
[Relationship between the concentration of antibodies to myosin heavy chains in serum and symptomatic carotid atherosclerosis]
Cataract
Correlation between the clinical phenotype of MYH9-related disease and tissue distribution of class II nonmuscle myosin heavy chains.
Generation and characterization of mice with Myh9 deficiency.
Life without double-headed non-muscle myosin II motor proteins.
Megakaryocyte and platelet abnormalities in a patient with a W33C mutation in the conserved SH3-like domain of myosin heavy chain IIA.
Melanosomes in pigmented epithelia maintain eye lens transparency during zebrafish embryonic development.
Mutations in non-muscle myosin 2A disrupt the actomyosin cytoskeleton in Sertoli cells and cause male infertility.
Non-muscle myosin heavy chain IIA and IIB interact and co-localize in living cells: Relevance for MYH9-related disease.
Non-muscle myosin IIA is required for the development of the zebrafish glomerulus.
Pathogenetic mechanisms of hematological abnormalities of patients with MYH9 mutations.
Regional-specific alterations in cell-cell junctions, cytoskeletal networks and myosin-mediated mechanical cues coordinate collectivity of movement of epithelial cells in response to injury.
The myosin chaperone UNC45B is involved in lens development and autosomal dominant juvenile cataract.
Celiac Disease
A family-based study does not confirm the association of MYO9B with celiac disease in the Italian population.
Association analysis of MYO9B gene polymorphisms with celiac disease in a Swedish/Norwegian cohort.
Association analysis of myosin IXB and type 1 diabetes.
Association between the MYO9B polymorphisms and celiac disease risk: a meta-analysis.
Genetic variation in myosin IXB is associated with ulcerative colitis.
Myo9B is associated with an increased risk of Barrett's esophagus and esophageal adenocarcinoma.
Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect.
Central Nervous System Diseases
Ginsenoside Rg1 Protects against Oxidative Stress-induced Neuronal Apoptosis through Myosin IIA-actin Related Cytoskeletal Reorganization.
Cerebral Palsy
Higher amount of MyHC IIX in a wrist flexor in tetraplegic compared to hemiplegic cerebral palsy.
Higher Expression of Myosin Heavy Chain IIx in Wrist Flexors in Cerebral Palsy.
Cerebrovascular Disorders
CCM2 and PAK4 act downstream of atrial natriuretic peptide signaling to promote cell spreading.
Moyamoya-like cerebrovascular disease in a child with a novel mutation in myosin heavy chain 11.
Chagas Cardiomyopathy
HLA and beta-myosin heavy chain do not influence susceptibility to Chagas disease cardiomyopathy.
Chagas Disease
A monoclonal antibody to Trypanosoma cruzi trypomastigotes recognizes a myosin tail epitope.
Autoimmunity in Chagas disease cardiopathy: biological relevance of a cardiac myosin-specific epitope crossreactive to an immunodominant Trypanosoma cruzi antigen.
Autoimmunity in Chagas' disease. Identification of cardiac myosin-B13 Trypanosoma cruzi protein crossreactive T cell clones in heart lesions of a chronic Chagas' cardiomyopathy patient.
Autoimmunity in Chagas' disease: specific inhibition of reactivity of CD4+ T cells against myosin in mice chronically infected with Trypanosoma cruzi.
Chagas' disease: polyspecificity of antibodies against Trypanosoma cruzi acidic antigens.
HLA and beta-myosin heavy chain do not influence susceptibility to Chagas disease cardiomyopathy.
Molecular mimicry between cardiac myosin and Trypanosoma cruzi antigen B13: identification of a B13-driven human T cell clone that recognizes cardiac myosin.
Myosin autoimmunity is not essential for cardiac inflammation in acute Chagas' disease.
Serum proteomic signature of human chagasic patients for the identification of novel potential protein biomarkers of disease.
T-cell molecular mimicry in Chagas disease: identification and partial structural analysis of multiple cross-reactive epitopes between Trypanosoma cruzi B13 and cardiac myosin heavy chain.
The Functional Characterization of TcMyoF Implicates a Family of Cytostome-Cytopharynx Targeted Myosins as Integral to the Endocytic Machinery of Trypanosoma cruzi.
Charcot-Marie-Tooth Disease
Effects of exercise and creatine on myosin heavy chain isoform composition in patients with Charcot-Marie-Tooth disease.
Nerve-dependent changes in skeletal muscle myosin heavy chain after experimental denervation and cross-reinnervation and in a demyelinating mouse model of Charcot-Marie-Tooth disease type 1A.
Cholera
Mechanisms of cholera toxin prevention of thrombin- and PMA-induced endothelial cell barrier dysfunction.
Regulation of acetylcholine receptor by cyclic AMP.
Cholestasis
Actomyosin contractility drives bile regurgitation as an early response during obstructive cholestasis.
Compound Heterozygous Myosin 5B (Myo5b) Mutation with Early Onset Progressive Cholestasis and No Intestinal Failure.
Defects in myosin VB are associated with a spectrum of previously undiagnosed low ?-glutamyltransferase cholestasis.
Monoclonal antibodies to rabbit hepatocyte myosin that cross-react with human liver myosin.
Mutations in Myosin 5B in Children With Early-onset Cholestasis.
Choriocarcinoma
Glycosyl modification facilitates homo- and hetero-oligomerization of the serotonin transporter. A specific role for sialic acid residues.
The purification and quantitation of myosin from cultured cells.
Choroideremia
Hereditary Retinal Dystrophy.
Cleft Lip
Association among polymorphisms at MYH9, environmental factors, and nonsyndromic orofacial clefts in western China.
Cleft lip with or without cleft palate: implication of the heavy chain of non-muscle myosin IIA.
Cleft Palate
Association among polymorphisms at MYH9, environmental factors, and nonsyndromic orofacial clefts in western China.
Cleft lip with or without cleft palate: implication of the heavy chain of non-muscle myosin IIA.
Deletion of the T-box transcription factor gene, Tbx1, in mice induces differential expression of genes associated with cleft palate in humans.
Clubfoot
Evaluation of embryonic and perinatal myosin gene mutations and the etiology of congenital idiopathic clubfoot.
Coinfection
Discovery of Viral Myosin Genes With Complex Evolutionary History Within Plankton.
Endomembranes and myosin mediate assembly into tubules of Pns10 of Rice dwarf virus and intercellular spreading of the virus in cultured insect vector cells.
Colitis
An abnormal rate of actin myosin cross-bridge cycling in colonic smooth muscle associated with experimental colitis.
Cortactin deficiency causes increased RhoA/ROCK1-dependent actomyosin contractility, intestinal epithelial barrier dysfunction, and disproportionately severe DSS-induced colitis.
IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction.
Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor.
Non-muscle myosin heavy chain 9 maintains intestinal homeostasis by preventing epithelium necroptosis and colitis adenoma formation.
Nonmuscle Myosin IIA Regulates Intestinal Epithelial Barrier in vivo and Plays a Protective Role During Experimental Colitis.
The class I myosin MYO1D binds to lipid and protects against colitis.
Colitis, Ulcerative
Adrenomedullin improves intestinal epithelial barrier function by downregulating myosin light chain phosphorylation in ulcerative colitis rats.
Association between genetic variants in myosin IXB and Crohn's disease.
Genetic variation in myosin IXB is associated with ulcerative colitis.
Myo9B is associated with an increased risk of Barrett's esophagus and esophageal adenocarcinoma.
Colonic Neoplasms
Brush border Myosin Ia has tumor suppressor activity in the intestine.
Cell fusion promotes chemoresistance in metastatic colon carcinoma.
Identification of the Myosin Heavy Polypeptide 9 as a Downstream Effector of the Proprotein Convertases in the Human Colon Carcinoma HT-29 Cells.
Induction of the stem-like cell regulator CD44 by Rho kinase inhibition contributes to the maintenance of colon cancer-initiating cells.
nm23-H1 reduces in vitro cell migration and the liver metastatic potential of colon cancer cells by regulating myosin light chain phosphorylation.
X-radiation enhances the collagen type I strap formation and migration potentials of colon cancer cells.
Color Vision Defects
Hereditary Retinal Dystrophy.
Colorectal Neoplasms
Brush border Myosin Ia has tumor suppressor activity in the intestine.
Brush border myosin Ia inactivation in gastric but not endometrial tumors.
Clinical significance of myosin in colorectal cancer.
Downregulation of myosin VI reduced cell growth and increased apoptosis in human colorectal cancer.
Evaluation of Parameters for Cancer-Induced Sarcopenia in Patients Autopsied after Death from Colorectal Cancer.
Identification of differential proteins in colorectal cancer cells treated with caffeic acid phenethyl ester.
Loss of Myosin Vb in colorectal cancer is a strong prognostic factor for disease recurrence.
Myosin Motors: Novel Regulators and Therapeutic Targets in Colorectal Cancer.
Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome.
Upregulation of myosin Va by Snail is involved in cancer cell migration and metastasis.
Vincristine promotes migration and invasion of colorectal cancer HCT116 cells through RhoA/ROCK/ Myosin light chain pathway.
Communicable Diseases
Cardiac myosin super relaxation (SRX): a perspective on fundamental biology, human disease and therapeutics.
Confusion
MicroRNA-200 family governs ovarian inclusion cyst formation and mode of ovarian cancer spread.
Congenital Abnormalities
Correlation between the clinical phenotype of MYH9-related disease and tissue distribution of class II nonmuscle myosin heavy chains.
Proteomics-based identification of novel proteins in temporal tendons of patients with masticatory muscle tendon-aponeurosis hyperplasia.
Vitamin C enhances vitamin E status and reduces oxidative stress indicators in sea bass larvae fed high DHA microdiets.
Contracture
Abnormal Activation of BMP Signaling Causes Myopathy in Fbn2 Null Mice.
Bioluminescent measurement in single cardiomyocytes of sudden cytosolic ATP depletion coincident with rigor.
Botulinum Toxin Type A Inhibits ?-Smooth Muscle Actin and Myosin II Expression in Fibroblasts Derived From Scar Contracture.
Clinical phenotypes and molecular genetic mechanisms of Carney complex.
Consequences of impeding in mitochondrial function in Physarum polycephalum. I. Reversible effects of anoxia, KCN, and influences of the Ca2+ ionophore A-23187.
Contractile and structural reactions to impediments of Ca2+-homeostasis in Physarum polycephalum.
Diastolic tension of rat cardiac muscle during deficiency of oxygen and glucose. Stress-strain relationships and reversibility.
Drosophila myosin mutants model the disparate severity of type 1 and type 2B distal arthrogryposis and indicate an enhanced actin affinity mechanism.
Effects of caffeine and tetracaine on outer hair cell shortening suggest intracellular calcium involvement.
Force and myosin light chain phosphorylation in dog airway smooth muscle activated in different ways.
Hereditary inclusion-body myopathies.
Mechanism of action of endothelin in rat cardiac muscle: cross-bridge kinetics and myosin light chain phosphorylation.
Modulation of rigor and myosin ATPase activity in rat cardiomyocytes.
Mutations in embryonic myosin heavy chain (MYH3) cause Freeman-Sheldon syndrome and Sheldon-Hall syndrome.
MYH3-associated distal arthrogryposis zebrafish model is normalized with para-aminoblebbistatin.
Myosin heavy chain expression in muscles of two cases of lethal congenital contracture syndrome.
Myosin heavy chain mutations that cause Freeman-Sheldon syndrome lead to muscle structural and functional defects in Drosophila.
Prolonged myosin binding increases muscle stiffness in Drosophila models of Freeman-Sheldon syndrome.
Remodelling of the heart after myocardial infarction.
Shortening velocity, myosin light chain phosphorylation and Ca2+ dependence of force during metabolic inhibition in smooth muscle of rat portal vein.
Studies on structural changes of F-actin and myosin in living, intact and damaged muscle fibres by means of polarized ultraviolet fluorescence microscopy.
[Experimental study of actin and myosin in the scar tissue]
[Myocardial mechanical injury in acute ischemia: a pathophysiologic and histopathologic review]
[The calcium pump in the sarcolemma controls smooth muscle relaxation]
Coronary Artery Disease
Altered expression of smooth muscle and non-muscle myosin heavy chain isoforms in rejected hearts: a sensitive marker for acute rejection and graft coronary arteriosclerosis.
Beta-myosin heavy chain myocytes are more resistant to changes in power output induced by ischemic conditions.
Circulating cardiac myosin light chains in patients with angina at rest: identification of a high risk subgroup.
Novel genes in LDL metabolism--a comprehensive overview.
Reduced cardiac myofibrillar Mg-ATPase activity without changes in myosin isozymes in patients with end-stage heart failure.
The utility of four biochemical markers in the triage of chest pain patients.
Ultrastructural findings in cardiac transplant recipients.
[Fractional composition of myocardial proteins and the adenosine triphosphate activity of myosin in hypertension and coronary atherosclerosis]
Coronary Disease
Calcium sensitivity and myosin light chain pattern of atrial and ventricular skinned cardiac fibers from patients with various kinds of cardiac disease.
Increased calcium sensitivity of chemically skinned human atria by myosin light chain kinase.
Relationship between myosin isoenzyme composition, hemodynamics, and myocardial structure in various forms of human cardiac hypertrophy.
[Cytotoxic effect of the lymphocytes in ischemic heart disease]
Coronary Occlusion
Alterations to myofibrillar protein function in nonischemic regions of the heart early after myocardial infarction.
Ca2+ sensitivity change and troponin loss in cardiac natural actomyosin after coronary occlusion.
Protection of ischemic myocardium in dogs using intracoronary 2,3-butanedione monoxime (BDM).
Regional changes in cardiac structural proteins in myocardial infarction: biochemical and histologic correlates.
Crohn Disease
Association between genetic variants in myosin IXB and Crohn's disease.
Myosin IXb variants and their pivotal role in maintaining the intestinal barrier: a study in Crohn's disease.
Cryptorchidism
Clinically Differentiated Abnormalities of the Architecture and Expression of Myosin Isoforms of the Human Cremaster Muscle in Cryptorchidism and Retractile Testis.
Embryonic myosin heavy chain and troponin T isoforms remain in the cremaster muscle of adult rat cryptorchidism induced with flutamide.
Orchidopexy restores morphometric-stereologic changes in the caput epididymis and daily sperm production in cryptorchidic mice, although sperm transit time and fertility parameters remain impaired.
Reduced expression of androgen receptor and Myosin heavy chain mRNA in cremaster muscle of boys with nonsyndromic cryptorchidism.
Cryptosporidiosis
[Cardiomyocyte myosin heavy chain composition change after cryptosporidial gastroenteritis].
Cushing Syndrome
Cushing's syndrome in early infancy due to isolated sporadic bilateral micronodular adrenocortical disease associated with myosin heavy chain 8 mutation: diagnostic challenges, too many!
Cystic Fibrosis
Defective CFTR apical endocytosis and enterocyte brush border in myosin VI-deficient mice.
Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells.
Myosin VI regulates endocytosis of the cystic fibrosis transmembrane conductance regulator.
{alpha}AP2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine.
Cysts
An actomyosin clamp assembled by the Amphiphysin-Rho1-Dia/DAAM-Rok pathway reinforces somatic cell membrane folded around spermatid heads.
Apical polarity proteins recruit the RhoGEF Cysts to promote junctional myosin assembly.
Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension.
Cystic Biliary Atresia and Choledochal Cysts Are Distinct Histopathologic Entities.
Dynein light chain 1 functions in somatic cyst cells regulate spermatogonial divisions in Drosophila.
MicroRNA-200 family governs ovarian inclusion cyst formation and mode of ovarian cancer spread.
Myosin II regulates the shape of three-dimensional intestinal epithelial cysts.
Protein phosphatase 1ß limits ring canal constriction during Drosophila germline cyst formation.
SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility.
The role of the actomyosin cytoskeleton in coordination of tissue growth during Drosophila oogenesis.
Transcription by RNA polymerase II during Acanthamoeba differentiation.
Withdrawal of skeletal muscle cells from cell cycle progression triggers differentiation of Toxoplasma gondii towards the bradyzoite stage.
[Salivary gland adenolymphomas as seen in current histochemical and immunomorphological research]
Cytomegalovirus Infections
An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking.
Analysis of the interactions between Rab GTPases and class V myosins.
Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3.
Cell differentiation is disrupted by MYO5B loss through Wnt/Notch imbalance.
Challenges of Microvillus Inclusion Disease in the NICU.
Defects in myosin VB are associated with a spectrum of previously undiagnosed low ?-glutamyltransferase cholestasis.
Drebrin E depletion in human intestinal epithelial cells mimics Rab8a loss of function.
Editing Myosin VB Gene to Create Porcine Model of Microvillus Inclusion Disease, With Microvillus-lined Inclusions and Alterations in Sodium Transporters.
Extraintestinal manifestations in an infant with microvillus inclusion disease: complications or features of the disease?
Functional characterization of mutations in the myosin Vb gene associated with microvillus inclusion disease.
Glucocorticoids and myosin5b loss of function induce heightened PKA signaling in addition to membrane traffic defects.
Identification of intestinal ion transport defects in microvillus inclusion disease.
Loss of MYO5B Leads to Reductions in Na+ Absorption with Maintenance of CFTR-dependent Cl- Secretion in Enterocytes.
Microvillus inclusion disease: loss of Myosin vb disrupts intracellular traffic and cell polarity.
Mouse cytomegalovirus infection induces antibodies which cross-react with virus and cardiac myosin: a model for the study of molecular mimicry in the pathogenesis of viral myocarditis.
Mutations in Myosin 5B in Children With Early-onset Cholestasis.
MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity.
Myosin 5b loss of function leads to defects in polarized signaling: implication for microvillus inclusion disease pathogenesis and treatment.
Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease.
Deaf-Blind Disorders
Abnormal phagocytosis by retinal pigmented epithelium that lacks myosin VIIa, the Usher syndrome 1B protein.
Dual Adeno-Associated Virus Vectors Result in Efficient In Vitro and In Vivo Expression of an Oversized Gene, MYO7A.
Effects of shaker-1 mutations on myosin-VIIa protein and mRNA expression.
Myosin VIIa participates in opsin transport through the photoreceptor cilium.
Usher I syndrome: unravelling the mechanisms that underlie the cohesion of the growing hair bundle in inner ear sensory cells.
[Usher syndrome type I and the differentiation of inner ear sensory cells' hair bundles]
Deafness
A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth.
A humanized mouse model, demonstrating progressive hearing loss caused by MYO6 p.C442Y, is inherited in a semi-dominant pattern.
A millennial myosin census.
A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells.
A novel allele of myosin VIIa reveals a critical function for the C-terminal FERM domain for melanosome transport in retinal pigment epithelial cells.
A novel type of myosin encoded by the mouse deafness gene shaker-2.
A point mutation in the SH1 helix alters elasticity and thermal stability of myosin II.
A type VII myosin encoded by the mouse deafness gene shaker-1.
A unique point mutation in the PMP22 gene is associated with Charcot-Marie-Tooth disease and deafness.
Advances in the understanding of MYH9 disorders.
Age-related changes in cochlear gene expression in normal and shaker 2 mice.
Analysis of two Arab families reveals additional support for a DFNB2 nonsyndromic phenotype of MYO7A.
Association of unconventional myosin MYO15 mutations with human nonsyndromic deafness DFNB3.
Autosomal dominant non-syndromic deafness caused by a mutation in the myosin VIIA gene.
Characterization of a Myosin VII MyTH/FERM Domain.
Characterization of a novel ENU-generated myosin VI mutant mouse strain with congenital deafness and vestibular dysfunction.
Characterization of a novel MYO3A missense mutation associated with a dominant form of late onset hearing loss.
Characterization of the human and mouse unconventional myosin XV genes responsible for hereditary deafness DFNB3 and shaker 2.
Characterization of unconventional MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice.
Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth.
Cloning and chromosomal localization of MYO15A to chromosome 5 of the dog (Canis familiaris).
Correction of deafness in shaker-2 mice by an unconventional myosin in a BAC transgene.
Correlation between the clinical phenotype of MYH9-related disease and tissue distribution of class II nonmuscle myosin heavy chains.
Detection of unique neutrophil non-muscle myosin heavy chain-A localization by immunofluorescence analysis in MYH9 disorder presented with macrothrombocytopenia without leukocyte inclusions and deafness.
Development of primary axosomatic endings in the anteroventral cochlear nucleus of mice.
Discovery of MYH14 as an important and unique deafness gene causing prelingually severe autosomal dominant nonsyndromic hearing loss.
Drosophila myosin VIIA is a high duty ratio motor with a unique kinetic mechanism.
Effects of shaker-1 mutations on myosin-VIIa protein and mRNA expression.
Electroretinographic anomalies in mice with mutations in Myo7a, the gene involved in human Usher syndrome type 1B.
ENU mutagenesis and the search for deafness genes.
Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B.
Expression of myosin VIIA during mouse embryogenesis.
FERM domain-containing unconventional myosin VIIA interacts with integrin ?5 subunit and regulates ?v?5-mediated cell adhesion and migration.
Generation and characterization of mice with Myh9 deficiency.
Genomic structure of the human unconventional myosin VI gene.
How are the cellular functions of myosin VI regulated within the cell?
Human deafness mutation of myosin VI (C442Y) accelerates the ADP dissociation rate.
Human myosin VIIA responsible for the Usher 1B syndrome: a predicted membrane-associated motor protein expressed in developing sensory epithelia.
Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9.
Identification of a Novel Mutation in the Myosin VIIA Motor Domain in a Family with Autosomal Dominant Hearing Loss (DFNA11).
Life without double-headed non-muscle myosin II motor proteins.
Loss of cargo binding in the human myosin VI deafness mutant (R1166X) increases actin filament binding.
Mariner is defective in myosin VIIA: a zebrafish model for human hereditary deafness.
Megakaryocyte and platelet abnormalities in a patient with a W33C mutation in the conserved SH3-like domain of myosin heavy chain IIA.
Multiple mutations of MYO1A, a cochlear-expressed gene, in sensorineural hearing loss.
Mutation analysis of the mouse myosin VIIA deafness gene.
Mutation spectrum of MYO7A and evaluation of a novel nonsyndromic deafness DFNB2 allele with residual function.
Mutations in non-muscle myosin 2A disrupt the actomyosin cytoskeleton in Sertoli cells and cause male infertility.
Mutations in the myosin VIIA gene cause non-syndromic recessive deafness.
MYO6, the human homologue of the gene responsible for deafness in Snell's waltzer mice, is mutated in autosomal dominant nonsyndromic hearing loss.
Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filaments.
Myosin VI and cardiomyopathy: Left ventricular hypertrophy, fibrosis, and both cardiac and pulmonary vascular endothelial cell defects in the Snell's waltzer mouse.
Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains.
Myosin VI deafness mutation prevents the initiation of processive runs on actin.
Myosin VI Is a Mediator of the p53-Dependent Cell Survival Pathway.
Myosin VI is required for E-cadherin-mediated border cell migration.
Myosin VI is required for structural integrity of the apical surface of sensory hair cells in zebrafish.
Myosin VI is required for the proper maturation and function of inner hair cell ribbon synapses.
Myosin VIIA defects, which underlie the Usher 1B syndrome in humans, lead to deafness in Drosophila.
Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly.
Myosin XVa localizes to the tips of inner ear sensory cell stereocilia and is essential for staircase formation of the hair bundle.
Myosin-X: a molecular motor at the cell's fingertips.
Myosins and deafness.
Myosins and pathology: genetics and biology.
Myosins: Domain Organisation, Motor Properties, Physiological Roles and Cellular Functions.
MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes.
Non-muscle myosin IIA is required for the development of the zebrafish glomerulus.
Novel association of hypertrophic cardiomyopathy, sensorineural deafness, and a mutation in unconventional myosin VI (MYO6).
Novel myosin VI isoform is abundantly expressed in retina.
Pathogenetic mechanisms of hematological abnormalities of patients with MYH9 mutations.
Phenotypic and expression analysis of a novel spontaneous myosin VI null mutant mouse.
Physical and functional interaction between protocadherin 15 and myosin VIIa in mechanosensory hair cells.
Prioritized sequencing of the second exon of MYO15A reveals a new mutation segregating in a Pakistani family with moderate to severe hearing loss.
Protein 4.1 expression in the developing hair cells of the mouse inner ear.
Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8.
Searching for evidence of DFNB2.
Shaker-1 mutations reveal roles for myosin VIIA in both development and function of cochlear hair cells.
Sisyphus, the Drosophila myosin XV homolog, traffics within filopodia transporting key sensory and adhesion cargos.
Stereocilia defects in waltzer (Cdh23), shaker1 (Myo7a) and double waltzer/shaker1 mutant mice.
Targeting of the hair cell proteins cadherin 23, harmonin, myosin XVa, espin, and prestin in an epithelial cell model.
The 133-kDa N-terminal domain enables myosin 15 to maintain mechanotransducing stereocilia and is essential for hearing.
The acquisition of mechano-electrical transducer current adaptation in auditory hair cells requires myosin VI.
The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 human deafness.
The curious incident of a cavum velum interpositum cyst in twins of a mother carrying May-Hegglin anomaly: a case report and short literature review.
The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals.
The motor and tail regions of myosin XV are critical for normal structure and function of auditory and vestibular hair cells.
The mouse Snell's waltzer deafness gene encodes an unconventional myosin required for structural integrity of inner ear hair cells.
The shaker-1 mouse myosin VIIa deafness mutation results in a severely reduced rate of the ATP hydrolysis step.
Unconventional myosins and the genetics of hearing loss.
Unravelling the genetics of deafness.
Vertebrate myosin VIIb is a high duty ratio motor adapted for generating and maintaining tension.
Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex.
Whirler mutant hair cells have less severe pathology than shaker 2 or double mutants.
Whole-exome sequencing to identify the cause of congenital sensorineural hearing loss in carriers of a heterozygous GJB2 mutation.
[Mutation screening in selected exons of myosin 7a gene in prelingual non-syndromic hearing impairment patients]
Death, Sudden, Cardiac
Autosomal recessive cardiomyopathy and sudden cardiac death associated with variants in MYL3.
Identification of novel protein kinase A phosphorylation sites in the M-domain of human and murine cardiac myosin binding protein-C using mass spectrometry analysis.
Induced Pluripotent Stem Cell-Derived Cardiomyocytes from a Patient with MYL2-R58Q-Mediated Apical Hypertrophic Cardiomyopathy Show Hypertrophy, Myofibrillar Disarray, and Calcium Perturbations.
Long-term outcome of 4 Korean families with hypertrophic cardiomyopathy caused by 4 different mutations.
Multidimensional structure-function relationships in human ?-cardiac myosin from population-scale genetic variation.
Prolonged Ca2+ and force transients in myosin RLC transgenic mouse fibers expressing malignant and benign FHC mutations.
Decompression Sickness
A model to account for the elastic element in muscle crossbridges in terms of a bending myosin rod.
An unexpectedly large working stroke from chymotryptic fragments of myosin II.
Atomic force microscopy of the myosin molecule.
Effects of phosphorylation by myosin light chain kinase on the structure of Limulus thick filaments.
Proteolytic fragmentation of Dictyostelium myosin and localization of the in vivo heavy chain phosphorylation site.
Skip residues correlate with bends in the myosin tail.
Structural dynamics of the myosin relay helix by time-resolved EPR and FRET.
Transient Pinning and Pulling: A Mechanism for Bending Microtubules.
Dehydration
COAGULATION OF MYOSIN BY DEHYDRATION.
PARAMETERS OF TEXTURE CHANGE IN PROCESSED FISH: CROSS-LINKAGE OF PROTEINS.
Reversible inactivation of myosin subfragment 1 activity by mechanical immobilization.
THE COAGULATION OF MYOSIN IN MUSCLE.
The effect of precipitation and dehydration on the physiologic and enzymatic properties of myosin and actomyosin.
Demyelinating Diseases
Accelerated repair of demyelinated CNS lesions in the absence of non-muscle myosin IIB.
Unconventional Myosin ID is Involved in Remyelination After Cuprizone-Induced Demyelination.
Y-39983, a Selective Rho-Kinase Inhibitor, Attenuates Experimental Autoimmune Encephalomyelitis via Inhibition of Demyelination.
Dengue
Life without double-headed non-muscle myosin II motor proteins.
Use of a tandem affinity purification assay to detect interactions between West Nile and dengue viral proteins and proteins of the mosquito vector.
Dental Pulp Calcification
Planar polarization of the denticle field in the Drosophila embryo: Roles for Myosin II (Zipper) and Fringe.
Dermatitis Herpetiformis
Myosin IXB gene region and gluten intolerance: linkage to coeliac disease and a putative dermatitis herpetiformis association.
Dermatitis, Atopic
Myosin heavy chain, a novel allergen for fish allergy in patients with atopic dermatitis.
Dermatitis, Phototoxic
Resolution doubling in live, multicellular organisms via multifocal structured illumination microscopy.
Dermatomyositis
Cardiac troponin and beta-type myosin heavy chain concentrations in patients with polymyositis or dermatomyositis.
Cytokines in juvenile dermatomyositis pathophysiology: potential and challenge.
Diffuse pruritic erythema as a clinical manifestation in anti-SAE antibody-associated dermatomyositis: a case report and literature review.
Recent developments in immunomodulatory peptides in juvenile rheumatic diseases: from trigger to dimmer?
Recurrent juvenile dermatomyositis and cutaneous necrotizing arteritis with molecular mimicry between streptococcal type 5 M protein and human skeletal myosin.
Self epitopes shared between human skeletal myosin and Streptococcus pyogenes M5 protein are targets of immune responses in active juvenile dermatomyositis.
Diabetes Insipidus, Nephrogenic
Sequence-specific "gene signatures" can be obtained by PCR with single specific primers at low stringency.
Diabetes Mellitus
Association between polymorphism rs2032487 in the non-muscle myosin heavy chain IIA gene (MHY9) and chronic kidney disease secondary to type 2 diabetes mellitus in a population of the Canary Islands.
Diabetes mellitus and hypothyroidism induce changes in myosin isoenzyme distribution in the rat heart--do alterations in fuel flux mediate these changes?
Diabetes mellitus induces changes in cardiac myosin of the rat.
Diabetes-induced changes of proteins synthesized by adult cardiac myocytes are partially reversed by insulin.
Fructose feeding increases Ca++-activated myosin ATPase activity and changes myosin isoenzyme distribution in the diabetic rat heart.
Influence of thyroid hormone administration on myosin ATPase activity and myosin isoenzyme distribution in the heart of diabetic rats.
Loss of fast-twitch isomyosins in skeletal muscles of the diabetic rat.
Melatonin Attenuates Aortic Endothelial Permeability and Arteriosclerosis in Streptozotocin-Induced Diabetic Rats: Possible Role of MLCK- and MLCP-Dependent MLC Phosphorylation.
Methyl palmoxirate increases Ca2+-myosin ATPase activity and changes myosin isoenzyme distribution in the diabetic rat heart.
Myosin Va but Not nNOS? is Significantly Reduced in Jejunal Musculomotor Nerve Terminals in Diabetes Mellitus.
New diagnostic and therapeutic possibilities for diastolic heart failure.
Non-enzymatic glycosylation of myosin: effects of diabetes and ageing.
Proposed regulation of gene expression by glucose in rodent heart.
Suo Quan Wan Protects Mouse From Early Diabetic Bladder Dysfunction by Mediating Motor Protein Myosin Va and Transporter Protein SLC17A9.
[Fibrinolysis modulators]
Diabetes Mellitus, Experimental
Responses of mouse fast and slow skeletal muscle to streptozotocin diabetes: myosin isoenzymes and phosphorous metabolites.
Diabetes Mellitus, Type 1
Altered calcium signaling in colonic smooth muscle of type 1 diabetic mice.
Association analysis of myosin IXB and type 1 diabetes.
Skeletal muscle myosin heavy chain synthesis in type 1 diabetes.
Smooth muscle myosin expression, isoform composition, and functional activities in rat corpus cavernosum altered by the streptozotocin-induced type 1 diabetes.
Diabetes Mellitus, Type 2
Association between polymorphism rs2032487 in the non-muscle myosin heavy chain IIA gene (MHY9) and chronic kidney disease secondary to type 2 diabetes mellitus in a population of the Canary Islands.
Expression profiling of insulin action in human myotubes: induction of inflammatory and pro-angiogenic pathways in relationship with glycogen synthesis and type 2 diabetes.
Human genome comparison of paretic and nonparetic vastus lateralis muscle in patients with hemiparetic stroke.
Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD.
Phosphorylation of myosin light chain in resting platelets from NIDDM patients is enhanced: correlation with spontaneous aggregation.
Suo Quan Wan Protects Mouse From Early Diabetic Bladder Dysfunction by Mediating Motor Protein Myosin Va and Transporter Protein SLC17A9.
The expression of myosin heavy chain (MHC) genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes.
Diabetic Cardiomyopathies
Activation of PPAR-? in the early stage of heart failure maintained myocardial function and energetics in pressure-overload heart failure.
Changes in crossbridge mechanical properties in diabetic rat cardiomyopathy.
ENGINEERED HEART TISSUE MODEL OF DIABETIC MYOCARDIUM.
Myosin heads are displaced from actin filaments in the in situ beating rat heart in early diabetes.
Myosin light-chain phosphorylation in diabetic cardiomyopathy in rats.
Regulation of contractile proteins in diabetic heart.
Therapy with Astragalus polysaccharides rescues lipotoxic cardiomyopathy in MHC-PPAR? mice.
Troponin subunits contribute to altered myosin ATPase activity in diabetic cardiomyopathy.
Diabetic Ketoacidosis
Cardiac antibody production to self-antigens in children and adolescents during and following the correction of severe diabetic ketoacidosis.
Diabetic Nephropathies
Pilot study of an association between a common variant in the non-muscle myosin heavy chain 9 (MYH9) gene and type 2 diabetic nephropathy in a Taiwanese population.
Diabetic Retinopathy
[Contractile elements in proliferative retinal diseases]
Diphtheria
[Myosin and diphtheria toxin.]
Disseminated Intravascular Coagulation
N-Methyl-3,4-methylendioxymethamphetamine (MDMA)-related coagulopathy and rhabdomyolysis: A case series and literature review.
Distal Myopathies
A de novo mutation of the MYH7 gene in a large Chinese family with autosomal dominant myopathy.
A novel mutation expands the genetic and clinical spectrum of MYH7-related myopathies.
A novel MYH7 mutation occurring independently in French and Norwegian Laing distal myopathy families and de novo in one Finnish patient.
A1603P and K1617del, Mutations in ?-Cardiac Myosin Heavy Chain that Cause Laing Early-Onset Distal Myopathy, Affect Secondary Structure and Filament Formation In Vitro and In Vivo.
Complex sarcolemmal invaginations mimicking myotendinous junctions in a case of Laing early-onset distal myopathy.
Hereditary myosin myopathies.
Laing early onset distal myopathy: slow myosin defect with variable abnormalities on muscle biopsy.
Laing Myopathy: Report of 4 New Families With Novel MYH7 Mutations, Double Mutations, and Severe Phenotype.
Muscle fibre type composition in distal myopathy (Welander). An analysis with enzyme- and immuno-histochemical, gel-electrophoretic and ultrastructural techniques.
Mutations in the slow skeletal muscle fiber myosin heavy chain gene (MYH7) cause laing early-onset distal myopathy (MPD1).
MYH7 mutation associated with two phenotypes of myopathy.
MYH7-related disorders in two Bulgarian families: Novel variants in the same region associated with different clinical manifestation and disease penetrance.
MYH7-related myopathies: clinical, histopathological and imaging findings in a cohort of Italian patients.
Myosinopathies: pathology and mechanisms.
New phenotype and pathology features in MYH7-related distal myopathy.
Novel Mutations Widen the Phenotypic Spectrum of Slow Skeletal/?-Cardiac Myosin (MYH7) Distal Myopathy.
Novel phenotypic variant in the MYH7 spectrum due to a stop-loss mutation in the C-terminal region: a case report.
Research progress of myosin heavy chain genes in human genetic diseases.
Symptomatic distal myopathy with cardiomyopathy due to a MYH7 mutation.
Thick filament diseases.
Variable phenotypic expression and onset in MYH14 distal hereditary motor neuropathy phenotype in a large, multigenerational North American family.
Zaspopathy in a large classic late-onset distal myopathy family.
Double Outlet Right Ventricle
Nonmuscle myosin II-B is required for normal development of the mouse heart.
Regulation of human heart contractility by essential myosin light chain isoforms.
Ductus Arteriosus, Patent
A deleterious MYH11 mutation causing familial thoracic aortic dissection.
Genetic basis of thoracic aortic aneurysms and dissections: potential relevance to abdominal aortic aneurysms.
Incomplete segregation of MYH11 variants with thoracic aortic aneurysms and dissections and patent ductus arteriosus.
Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus.
SWI/SNF complexes containing Brahma or Brahma-related gene 1 play distinct roles in smooth muscle development.
Dwarfism
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Recent Advances in Understanding Plant Myosin Function: Life in the Fast Lane.
Dwarfism, Pituitary
Hereditary pituitary dwarfism in mice affects skeletal and cardiac myosin isozyme transitions differently.
Dyskinesias
Abnormal movement of tropomyosin and response of myosin heads and actin during the ATPase cycle caused by the Arg167His, Arg167Gly and Lys168Glu mutations in TPM1 gene.
Virulence and functions of myosin II are inhibited by overexpression of light meromyosin in Entamoeba histolytica.
Dyslipidemias
The MYLIP p.N342S polymorphism is associated with response to lipid-lowering therapy in Brazilian patients with familial hypercholesterolemia.
Dystocia
Uterine expression of smooth muscle alpha- and gamma-actin and smooth muscle myosin in bitches diagnosed with uterine inertia and obstructive dystocia.
Dystonia
Dystonia musculorum mutation and myosin heavy chain expression in skeletal and cardiac muscles.
Echinococcosis
[Organ pathology in chronic tissue-dwelling helminthic infections: role of blood and tissue eosinophilia, immunoglobulinemia E, G4, and immune response-inducing factors]
Elephantiasis, Filarial
Differential recognition of two cloned Brugia malayi antigens by antibody class.
Localization of paramyosin, myosin, and a heat shock protein 70 in larval and adult Brugia malayi.
Molecular cloning, purification and characterisation of myosin of human lymphatic filarial parasite Brugia malayi.
Empyema
Myocardin is Involved in Mesothelial-Mesenchymal Transition of Human Pleural Mesothelial Cells.
Encephalomyelitis
CD24 and myosin light polypeptide 2 are involved in prevention of experimental autoimmune encephalomyelitis by myelin basic protein-pulsed dendritic cells.
In situ detection of autoreactive CD4 T cells in brain and heart using major histocompatibility complex class II dextramers.
The motorized RhoGAP myosin IXb (Myo9b) in leukocytes regulates experimental autoimmune encephalomyelitis induction and recovery.
Encephalomyelitis, Autoimmune, Experimental
CD24 and myosin light polypeptide 2 are involved in prevention of experimental autoimmune encephalomyelitis by myelin basic protein-pulsed dendritic cells.
In situ detection of autoreactive CD4 T cells in brain and heart using major histocompatibility complex class II dextramers.
The motorized RhoGAP myosin IXb (Myo9b) in leukocytes regulates experimental autoimmune encephalomyelitis induction and recovery.
Endocardial Fibroelastosis
Sarcomere protein gene mutations and inherited heart disease: a beta-cardiac myosin heavy chain mutation causing endocardial fibroelastosis and heart failure.
Endometriosis
Identification of biomarkers for endometriosis in eutopic endometrial cells from patients with endometriosis using a proteomics approach.
Identification of endometriosis-associated genes and pathways based on bioinformatic analysis.
Eosinophilia
Inversion and deletion of 16q22 defined by array CGH, FISH, and RT-PCR in a patient with AML.
Lymphoplasmacytic lymphoma/Waldenström macroglobulinemia with inv(16)(p13q22) as a sole genetic abnormality.
Toxic neuropathies and myopathies.
Eosinophilia-Myalgia Syndrome
Toxic neuropathies and myopathies.
Epiretinal Membrane
Actin filaments in contracting preretinal membranes.
Microfilaments in preretinal membrane cells of proliferative vitreoretinopathy.
Epstein-Barr Virus Infections
Nonmuscle myosin heavy chain IIA mediates Epstein-Barr virus infection of nasopharyngeal epithelial cells.
Erectile Dysfunction
Myosin Va plays a role in nitrergic smooth muscle relaxation in gastric fundus and corpora cavernosa of penis.
Escherichia coli Infections
Phosphorylation of myosin light chain at distinct sites and its association with the cytoskeleton during enteropathogenic Escherichia coli infection.
Esophageal Achalasia
Myosin heavy chain composition and fiber size of the cricopharyngeus muscle in patients with achalasia and normal subjects.
Esophageal Neoplasms
Nonmuscle myosin IIA is associated with poor prognosis of esophageal squamous cancer.
Esophageal Squamous Cell Carcinoma
Aberrant expression of MYH9 and E-cadherin in esophageal squamous cell carcinoma and their relationship to vasculogenic mimicry.
Expression and prognostic significance of MYL9 in esophageal squamous cell carcinoma.
MYH9 promotes cell metastasis via inducing Angiogenesis and Epithelial Mesenchymal Transition in Esophageal Squamous Cell Carcinoma.
Myosin 5a regulates tumor migration and epithelial-mesenchymal transition in esophageal squamous cell carcinoma: utility as a prognostic factor.
Essential Hypertension
The role of the adrenal cortex in human essential hypertension: keynote address.
Exotropia
Ultrastructure of medial rectus muscles in patients with intermittent exotropia.
Extranodal Extension
Comparison of the efficiency of transgelin, smooth muscle myosin, and CD31 antibodies for the assessment of vascular tumor invasion and free tumor deposits in gastric, pancreatic, and colorectal adenocarcinomas.
Fasciculation
A micropatterned coculture system for axon guidance reveals that Slit promotes axon fasciculation and regulates the expression of L1CAM.
Fasciitis
Differential expression of smooth muscle myosin, smooth muscle actin, h-caldesmon, and calponin in the diagnosis of myofibroblastic and smooth muscle lesions of skin and soft tissue.
Proliferative myositis and fasciitis. Report of five cases with an ultrastructural and immunohistochemical study.
Fetal Growth Retardation
Nutrition-hormone receptor-gene interactions: implications for development and disease.
Fibroma
Characterization of antibodies to smooth muscle myosin kinase and their use in localizing myosin kinase in nonmuscle cells.
Collagen modulates cell shape and cytoskeleton of embryonic corneal and fibroma fibroblasts: distribution of actin, alpha-actinin, and myosin.
Differential expression of smooth muscle myosin, smooth muscle actin, h-caldesmon, and calponin in the diagnosis of myofibroblastic and smooth muscle lesions of skin and soft tissue.
Infantile digital fibromatosis. Identification of actin filaments in cytoplasmic inclusions by heavy meromyosin binding.
Fibrosarcoma
[Mechanism of endothelial Rho/Rho kinase in extravascular Migration of fibrosarcoma cell]
Frontotemporal Dementia
Filamin-A and Myosin VI colocalize with fibrillary Tau protein in Alzheimer's disease and FTDP-17 brains.
VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.
Gait Disorders, Neurologic
Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness.
Gallstones
The study on the relationship between the expression of calponin and gallstone formation.
Gastroenteritis
[Cardiomyocyte myosin heavy chain composition change after cryptosporidial gastroenteritis].
Gastrointestinal Diseases
Myo9B is associated with an increased risk of Barrett's esophagus and esophageal adenocarcinoma.
The Regulation of Intestinal Mucosal Barrier by Myosin Light Chain Kinase/Rho Kinases.
Gastrointestinal Stromal Tumors
Embryonic form of smooth muscle myosin heavy chain (SMemb/MHC-B) in gastrointestinal stromal tumor and interstitial cells of Cajal.
Expression of embryonic-form smooth muscle myosin heavy chain in a gastrointestinal stromal tumor of the greater omentum.
Gastroparesis
Myosin Va plays a role in nitrergic smooth muscle relaxation in gastric fundus and corpora cavernosa of penis.
Genetic Diseases, Inborn
Cochlear implantation in a patient with Epstein syndrome.
Homology modeling and global computational mutagenesis of human myosin VIIa.
Hypertrophic and Dilated Cardiomyopathy: Four Decades of Basic Research on Muscle Lead to Potential Therapeutic Approaches to These Devastating Genetic Diseases.
Late Manifestation of Massive Jejunal and Cecal Varices Post Liver and Small Bowel Transplantation in a Patient With Microvillus Inclusion Disease.
MYH9-related disorders: report on a patient of Greek origin presenting with macroscopic hematuria and presenile cataract, caused by an R1165C mutation.
Research progress of myosin heavy chain genes in human genetic diseases.
Successful Renal Transplantation in MYH9-Related Disorder With Severe Macrothrombocytopenia: First Report in Korea.
Gitelman Syndrome
Heterogeneous expression of nonmuscle myosin heavy chain-B in mesangial cells of patients with Gitelman's syndrome.
Glaucoma
Blebbistatin, a novel inhibitor of myosin II ATPase activity, increases aqueous humor outflow facility in perfused enucleated porcine eyes.
Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin.
Deletion of myosin VI causes slow retinal optic neuropathy and age-related macular degeneration (AMD)-relevant retinal phenotype.
Did myocilin evolve from two different primordial proteins?
Dose- and time-dependent effects of actomyosin inhibition on live mouse outflow resistance and aqueous drainage tissues.
Scleral fibroblast response to experimental glaucoma in mice.
Glaucoma, Open-Angle
Cloning and characterization of subtracted cDNAs from a human ciliary body library encoding TIGR, a protein involved in juvenile open angle glaucoma with homology to myosin and olfactomedin.
Did myocilin evolve from two different primordial proteins?
Glioblastoma
Coordination of glioblastoma cell motility by PKC?.
Expression pattern and prognostic significance of myosin light chain 9 (MYL9): a novel biomarker in glioblastoma.
Myosin 10 Regulates Invasion, Mitosis, and Metabolic Signaling in Glioblastoma.
Myosin IIA suppresses glioblastoma development in a mechanically sensitive manner.
Glioma
Direct inhibition of myosin II effectively blocks glioma invasion in the presence of multiple motogens.
Effect of Rho-associated kinase inhibition on actin cytoskeleton structure and calcium response in glioma C6 cells.
Glioma cell migration on three-dimensional nanofiber scaffolds is regulated by substrate topography and abolished by inhibition of STAT3 signaling.
Glioma migration can be blocked by nontoxic inhibitors of myosin II.
Inhibition of myosin II triggers morphological transition and increased nuclear motility.
Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity.
Isolation and characterization of myosin from cloned rat glioma and mouse neuroblastoma cells.
Mechanical Durotactic Environment Enhances Specific Glioblastoma Cell Responses.
Mer receptor tyrosine kinase promotes invasion and survival in glioblastoma multiforme.
MSAP enhances migration of C6 glioma cells through phosphorylation of the myosin regulatory light chain.
Myosin Heavy Chain 10 (MYH10) Gene Silencing Reduces Cell Migration and Invasion in the Glioma Cell Lines U251, T98G, and SHG44 by Inhibiting the Wnt/?-Catenin Pathway.
Myosin VI contributes to malignant proliferation of human glioma cells.
Pyr3 Induces Apoptosis and Inhibits Migration in Human Glioblastoma Cells.
Retraction notice to: Myosin VI contributes to malignant proliferation of human glioma cells.
Role of lysophosphatidic acid and rho in glioma cell motility.
Shifting the optimal stiffness for cell migration.
The role of myosin II in glioma invasion of the brain.
The role of myosin II in glioma invasion: A mathematical model.
Glomerulonephritis
Advances in the understanding of MYH9 disorders.
CKD in MYH9-related disorders.
Elevated levels of IgG specific antimyosin antibodies in acute rheumatic fever (ARF): differential profiles of antibodies to myosin and soluble myocardial antigens in ARF, acute glomerulonephritis and group A streptococcal pharyngitis.
Epitopes of streptococcal M proteins shared with cardiac myosin.
Genetics, clinical and pathological features of glomerulonephritis associated with mutations of nonmuscle myosin IIA (Fechtner syndrome).
Increased expression of a brain/embryo-type myosin heavy chain isoform (MIIB2) in mesangial proliferative glomerulonephritis.
Mesangial expression of a nonmuscle myosin heavy chain, SMemb, is associated with glomerular sclerosis and renal prognosis in IgA nephropathy.
Non-muscle myosin heavy chain IIA and IIB interact and co-localize in living cells: Relevance for MYH9-related disease.
Pathogenetic mechanisms of hematological abnormalities of patients with MYH9 mutations.
Safety evaluation of GX-12. A new DNA vaccine for HIV infection in rodents.
Glomerulonephritis, IGA
Increased expression of a brain/embryo-type myosin heavy chain isoform (MIIB2) in mesangial proliferative glomerulonephritis.
Mesangial expression of a nonmuscle myosin heavy chain, SMemb, is associated with glomerular sclerosis and renal prognosis in IgA nephropathy.
Polymorphisms in the nonmuscle myosin heavy chain 9 gene (MYH9) are associated with the progression of IgA nephropathy in Chinese.
Glomerulosclerosis, Focal Segmental
Effects of FSGS-associated mutations on the stability and function of myosin-1 in fission yeast.
Essential hypertension and risk of nephropathy: a reappraisal.
Glomerular nonmuscle-type myosin heavy-chain isoform gene expression in glomerulosclerosis.
MYH9 and APOL1 are both associated with sickle cell disease nephropathy.
Nonmuscle Myosin II Regulates the Morphogenesis of Metanephric Mesenchyme-Derived Immature Nephrons.
Patients with Epstein-Fechtner syndromes owing to MYH9 R702 mutations develop progressive proteinuric renal disease.
Podocyte expression of nonmuscle myosin heavy chain-IIA decreases in idiopathic nephrotic syndrome, especially in focal segmental glomerulosclerosis.
Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans.
Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans.
Polymorphisms in the Nonmuscle Myosin Heavy Chain 9 Gene (MYH9) Are Associated with Albuminuria in Hypertensive African Americans: The HyperGEN Study.
Rho-GTPase Activating Protein myosin MYO9A identified as a novel candidate gene for monogenic focal segmental glomerulosclerosis.
Glomus Tumor
Cytoskeletal characterization of arteriovenous epithelioid cells.
Glomus tumor cells: evaluation of smooth muscle and endothelial cell properties.
Glomus tumor of the cheek: an immunohistochemical demonstration of actin and myosin.
Glucose Intolerance
Human genome comparison of paretic and nonparetic vastus lateralis muscle in patients with hemiparetic stroke.
Glycogen Storage Disease Type V
McArdle disease does not affect skeletal muscle fibre type profiles in humans.
Gout
ALPK1 phosphorylates myosin IIA modulating TNF-? trafficking in gout flares.
Corrigendum: ALPK1 phosphorylates myosin IIA modulating TNF-? trafficking in gout flares.
Graves Disease
Leukocyte migration test for the study of immune reactivity in cases of Graves disease associated with infiltrative ophthalmopathy.
Graves Ophthalmopathy
Leukocyte migration test for the study of immune reactivity in cases of Graves disease associated with infiltrative ophthalmopathy.
Head and Neck Neoplasms
MicroRNA-363 targets myosin 1B to reduce cellular migration in head and neck cancer.
The tumor suppressor capability of p53 is dependent on non-muscle myosin IIA function in head and neck cancer.
Hearing Disorders
Mariner is defective in myosin VIIA: a zebrafish model for human hereditary deafness.
Hearing Loss
A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIA.
A Mutation in Myo15 Leads to Usher-Like Symptoms in LEW/Ztm-ci2 Rats.
A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells.
A new compartment at stereocilia tips defined by spatial and temporal patterns of myosin IIIa expression.
A novel missense variant in MYO3A is associated with autosomal dominant high-frequency hearing loss in a German family.
A novel MYO6 splice site mutation causes autosomal dominant sensorineural hearing loss type DFNA22 with a favourable outcome after cochlear implantation.
A novel nonsense mutation in MYO6 is associated with progressive nonsyndromic hearing loss in a Danish DFNA22 family.
A novel splice site mutation of myosin VI in mice leads to stereociliary fusion caused by disruption of actin networks in the apical region of inner ear hair cells.
An introduction to the genetics of normal and defective hearing.
Analysis of DNA elements that modulate myosin VIIA expression in humans.
Anesthetic Management of Living-Donor Renal Transplantation in a Patient With Epstein Syndrome Using Rotational Thromboelastometry: A Case Report.
Are MYO1C and MYO1F associated with hearing loss?
Chaperone-enhanced purification of unconventional myosin 15, a molecular motor specialized for stereocilia protein trafficking.
Cloning and developmental expression of nonmuscle myosin IIA (Myh9) in the mammalian inner ear.
Cloning and distribution of myosin 3B in the mouse retina: Differential distribution in cone outer segments.
Discovery of MYH14 as an important and unique deafness gene causing prelingually severe autosomal dominant nonsyndromic hearing loss.
Erratum: analysis of DNA elements that modulate myosin VIIa expression in humans.
Expression of Myh9 in the mammalian cochlea: localization within the stereocilia.
From flies' eyes to our ears: mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30.
Functional Role of Class III Myosins in Hair Cells.
Genetic association of MYH genes with hereditary hearing loss in Korea.
Genetic causes of hearing loss.
Genetic heterogeneity of deafness phenotypes linked to DFNA4.
Genotype-phenotype relationship in three cases with overlapping 19p13.12 microdeletions.
Identification and functional study of a new missense mutation in the motor head domain of myosin VIIA in a family with autosomal dominant hearing impairment (DFNA11).
Identification and molecular modelling of a mutation in the motor head domain of myosin VIIA in a family with autosomal dominant hearing impairment (DFNA11).
Identification of a Novel Mutation in the Myosin VIIA Motor Domain in a Family with Autosomal Dominant Hearing Loss (DFNA11).
Identification of novel variants in the Myosin VIIA gene of patients with nonsyndromic hearing loss from Taiwan.
Impaired calmodulin binding of myosin-7A causes autosomal dominant hearing loss (DFNA11).
Inhibition of Myo6 gene expression by co?expression of a mutant of transcription factor POU4F3 (BRN?3C) in hair cells.
Localization in stereocilia, plasma membrane, and mitochondria suggests diverse roles for NMHC-IIa within cochlear hair cells.
Loss of cargo binding in the human myosin VI deafness mutant (R1166X) increases actin filament binding.
Mild Maternal Iron Deficiency Anemia Induces Hearing Impairment Associated with Reduction of Ribbon Synapse Density and Dysregulation of VGLUT3, Myosin VIIa, and Prestin Expression in Young Guinea Pigs.
Mouse class III myosins: kinase activity and phosphorylation sites.
Mutations in the gamma-actin gene (ACTG1) are associated with dominant progressive deafness (DFNA20/26).
Mutations of MYO6 are associated with recessive deafness, DFNB37.
MYO15A (DFNB3) mutations in Turkish hearing loss families and functional modeling of a novel motor domain mutation.
Nonmuscle myosin heavy-chain gene MYH14 is expressed in cochlea and mutated in patients affected by autosomal dominant hearing impairment (DFNA4).
Novel mutations in MYTH4-FERM domains of myosin 15 are associated with autosomal recessive nonsyndromic hearing loss.
Novel mutations of MYO15A associated with profound deafness in consanguineous families and moderately severe hearing loss in a patient with Smith-Magenis syndrome.
Novel myosin mutations for hereditary hearing loss revealed by targeted genomic capture and massively parallel sequencing.
Phenotype of DFNA11: a nonsyndromic hearing loss caused by a myosin VIIA mutation.
Prioritized sequencing of the second exon of MYO15A reveals a new mutation segregating in a Pakistani family with moderate to severe hearing loss.
Proteomic analysis of the organ of corti using nanoscale liquid chromatography coupled with tandem mass spectrometry.
Reinforcement of a minor alternative splicing event in MYO7A due to a missense mutation results in a mild form of retinopathy and deafness.
Spectrum of MYO7A Mutations in an Indigenous South African Population Further Elucidates the Nonsyndromic Autosomal Recessive Phenotype of DFNB2 to Include Both Homozygous and Compound Heterozygous Mutations.
The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals.
The effect of novel mutations on the structure and enzymatic activity of unconventional myosins associated with autosomal dominant non-syndromic hearing loss.
The R941L mutation in MYH14 disrupts mitochondrial fission and associates with peripheral neuropathy.
Unconventional myosin VIIA is a novel A-kinase-anchoring protein.
Unconventional myosins and the genetics of hearing loss.
Variable hearing impairment in a DFNB2 family with a novel MYO7A missense mutation.
Variable phenotypic expression and onset in MYH14 distal hereditary motor neuropathy phenotype in a large, multigenerational North American family.
[Mutation screening in selected exons of myosin 7a gene in prelingual non-syndromic hearing impairment patients]
[Myosin VI: involvement in hereditary hearing loss]
Hearing Loss, Sensorineural
A genotypic ascertainment approach to refute the association of MYO1A variants with non-syndromic deafness.
Modification of human hearing loss by plasma-membrane calcium pump PMCA2.
Myo1c mutations associated with hearing loss cause defects in the interaction with nucleotide and actin.
myosin 7aa(-/-) mutant zebrafish show mild photoreceptor degeneration and reduced electroretinographic responses.
Non-muscle myosin heavy chain IIA and IIB interact and co-localize in living cells: Relevance for MYH9-related disease.
Nonmuscle Myosin Heavy Chain IIA Mutation Predicts Severity and Progression of Sensorineural Hearing Loss in Patients With MYH9-Related Disease.
Reinforcement of a minor alternative splicing event in MYO7A due to a missense mutation results in a mild form of retinopathy and deafness.
Heart Arrest
Different intracellular compartmentations of cardiac troponins and myosin heavy chains: a causal connection to their different early release after myocardial damage.
Heart Defects, Congenital
A Novel Alpha Cardiac Actin (ACTC1) Mutation Mapping to a Domain in Close Contact with Myosin Heavy Chain Leads to a Variety of Congenital Heart Defects, Arrhythmia and Possibly Midline Defects.
Alpha-cardiac myosin heavy chain (MYH6) mutations affecting myofibril formation are associated with congenital heart defects.
A Dutch MYH7 founder mutation, p.(Asn1918Lys), is associated with early onset cardiomyopathy and congenital heart defects.
Cardiac troponin T is necessary for normal development in the embryonic chick heart.
Coexpression of alpha and beta myosin heavy-chain isoforms in atria of neonates and infants with congenital heart disease.
Congenital Heart Disease Linked to Maternal Autoimmunity against Cardiac Myosin.
Ebstein's Anomaly: Genetics, Clinical Manifestations, and Management.
Expression of ventricular myosin subunits in the atria of children with congenital heart malformations.
Functional characterization of the human atrial essential myosin light chain (hALC-1) in a transgenic rat model.
Human atrial myosin light chain 1 expression attenuates heart failure.
Nonmuscle myosin II-B is required for normal development of the mouse heart.
Regulation of human heart contractility by essential myosin light chain isoforms.
[Restriction fragment length polymorphism analysis of ventricular myosin light chain 1 gene in families with congenital heart disease]
Heart Diseases
A myosin missense mutation, not a null allele, causes familial hypertrophic cardiomyopathy.
A striking common O-linked N-acetylglucosaminyl moiety between cruzipain and myosin.
A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy.
Applications of anticardiac myosin monoclonal antibodies in the diagnosis of heart disease.
Autoantibodies against human ventricular myosin in sera of patients with acute and chronic myocarditis.
Autoantibodies in hypertrophic cardiomyopathy and their clinical significance.
Autoantibodies specific for the cardiac myosin isoform are found in mice susceptible to Coxsackievirus B3-induced myocarditis.
Autoimmune myocarditis, valvulitis, and cardiomyopathy.
Calcium sensitivity and myosin light chain pattern of atrial and ventricular skinned cardiac fibers from patients with various kinds of cardiac disease.
Cardiac myosin autoimmunity in acute Chagas' heart disease.
Cardiac myosin binding protein C phosphorylation in cardiac disease.
Cardiac myosin heavy chains lacking the light chain binding domain cause hypertrophic cardiomyopathy in mice.
Cardiac myosin induces myocarditis in genetically predisposed mice.
Cardiac myosin-induced myocarditis: target recognition by autoreactive T cells requires prior activation of cardiac interstitial cells.
Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions.
Cellular and molecular mechanisms of murine autoimmune myocarditis.
Characterization of myosin from patients with asymmetric septal hypertrophy.
Chlamydia infections and heart disease linked through antigenic mimicry.
CK-1827452, a sarcomere-directed cardiac myosin activator for acute and chronic heart disease.
Combined analysis of cross-reacting antibodies anti-?1AR and anti-B13 in advanced stages of Chagas heart disease.
Congenital Heart Disease Linked to Maternal Autoimmunity against Cardiac Myosin.
Consequences of unlocking the cardiac myosin molecule in human myocarditis and cardiomyopathies.
Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice.
Contractile protein mutations and heart disease.
Depressed cardiac tension cost in experimental diabetes is due to altered myosin heavy chain isoform expression.
Disease mutations in striated muscle myosins.
Doxorubicin-Induced Cardiotoxicity in Collaborative Cross (CC) Mice Recapitulates Individual Cardiotoxicity in Humans.
Effects of cardiac Myosin binding protein-C on actin motility are explained with a drag-activation-competition model.
Effects of mavacamten on Ca2+ -sensitivity of contraction as sarcomere length varied in human myocardium.
Functions of myosin light chain-2 (MYL2) in cardiac muscle and disease.
Genome-wide compendium and functional assessment of in vivo heart enhancers.
Hereditary heart disease: pathophysiology, clinical presentation, and animal models of HCM, RCM, and DCM associated with mutations in cardiac myosin light chains.
High-Resolution Cryo-EM Structure of the Cardiac Actomyosin Complex.
Hypertrophic cardiomyopathy ?-cardiac myosin mutation (P710R) leads to hypercontractility by disrupting super relaxed state.
Identification of alpha- and beta-cardiac myosin heavy chain isoforms as major autoantigens in dilated cardiomyopathy.
Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice.
Induction of autoimmune myocarditis in interleukin-2-deficient mice.
Induction of autoimmune valvular heart disease by recombinant streptococcal m protein.
Isolation and characterization of myosin from subjects with asymmetric septal hypertrophy.
Mavacamten decreases maximal force and Ca2+ sensitivity in the N47K-myosin regulatory light chain mouse model of hypertrophic cardiomyopathy.
Modulating Beta-Cardiac Myosin Function at the Molecular and Tissue Levels.
Molecular mechanisms of cardiomyopathy phenotypes associated with myosin light chain mutations.
Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease.
Muscle myosin filaments: cores, crowns and couplings.
Myocardial adaptive changes and damage in ischemic heart disease.
Myofilament dysfunction in cardiac disease from mice to men.
Myosin filament-based regulation of the dynamics of contraction in heart muscle.
Myosin heavy chain composition and the economy of contraction in healthy and diseased human myocardium.
Myosin isoenzymes in normal and hypertrophied human ventricular myocardium.
Myosin regulatory light chain (RLC) phosphorylation change as a modulator of cardiac muscle contraction in disease.
Nasal cardiac myosin peptide treatment and OX40 blockade protect mice from acute and chronic virally-induced myocarditis.
Neural/Bayes network predictor for inheritable cardiac disease pathogenicity and phenotype.
Prevention of autoimmune myocarditis through the induction of antigen-specific peripheral immune tolerance.
Regulatory light chain mutants linked to heart disease modify the cardiac myosin lever arm.
Rs4968309 in Myosin Light Chain 4 (MYL4) Associated With Atrial Fibrillation Onset and Predicts Clinical Outcomes After Catheter Ablation in Atrial Fibrillation Patients Without Structural Heart Disease.
Sarcomere protein gene mutations and inherited heart disease: a beta-cardiac myosin heavy chain mutation causing endocardial fibroelastosis and heart failure.
Second-harmonic generation and two-photon-excited autofluorescence microscopy of cardiomyocytes: quantification of cell volume and myosin filaments.
Structure, stability and dynamics of the central domain of cardiac myosin binding protein C (MyBP-C): implications for multidomain assembly and causes for cardiomyopathy.
T cell mimicry in inflammatory heart disease.
T cells in cardiac myosin-induced myocarditis.
The N-Terminal Domains of Myosin Binding Protein C Can Bind Polymorphically to F-Actin.
The pathogenesis of postinfectious myocarditis.
Thick Filament Mechano-Sensing in Skeletal and Cardiac Muscles: A Common Mechanism Able to Adapt the Energetic Cost of the Contraction to the Task.
Too much of a good thing.
Uncured PDMS inhibits myosin in vitro motility in a microfluidic flow cell.
Viral myocarditis.
[Changes in the regulatory domain of the myosin head observed in some heart diseases]
[Composition of myosin light chains from the human myocardium: prospects for diagnosis of cardiac diseases]
[Contractile myocardial proteins in patients with acquired heart defects]
Heart Failure
A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia.
A high-performance liquid chromatography assay for quantification of cardiac myosin heavy chain isoform protein expression.
A New Approach to Inotropic Therapy in the Treatment of Heart Failure: Cardiac Myosin Activators.
A novel approach to improve cardiac performance: cardiac myosin activators.
A spontaneous model for autoimmune myocarditis using the human MHC molecule HLA-DQ8.
Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation.
Activation of PPAR-? in the early stage of heart failure maintained myocardial function and energetics in pressure-overload heart failure.
Acute Treatment With Omecamtiv Mecarbil to Increase Contractility in Acute Heart Failure: The ATOMIC-AHF Study.
Adenylate kinase-catalyzed phosphotransfer in the myocardium : increased contribution in heart failure.
Allosteric modulation of cardiac myosin dynamics by omecamtiv mecarbil.
alpha-Adrenergic response and myofilament activity in mouse hearts lacking PKC phosphorylation sites on cardiac TnI.
Alterations in myosin heavy chain isoform gene expression during the transition from compensatory hypertrophy to congestive heart failure in rats.
Alterations in skeletal muscle gene expression in the rat with chronic congestive heart failure.
Altered C10 domain in cardiac myosin binding protein-C results in hypertrophic cardiomyopathy.
Altered expression of myosin heavy chain in human skeletal muscle in chronic heart failure.
Altered myofilament stoichiometry in response to heart failure in a cardioprotective ?-myosin heavy chain transgenic rabbit model.
Altered sarcoplasmic reticulum Ca2(+)-ATPase gene expression in the human ventricle during end-stage heart failure.
Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility.
Beneficial effects on skeletal muscle of the angiotensin II type 1 receptor blocker irbesartan in experimental heart failure.
Calcium sensitivity and myosin light chain pattern of atrial and ventricular skinned cardiac fibers from patients with various kinds of cardiac disease.
Carbonylation of atrial myosin prolongs its interaction with actin.
Cardiac alterations at the myofibrillar level: is a redistribution of the myosin isoenzyme pattern decisive for cardiac failure in haemodynamic overload?
Cardiac contractile proteins in hypertrophied and failing guinea pig heart.
Cardiac muscle organization revealed in 3-D by imaging whole-mount mouse hearts using two-photon fluorescence and confocal microscopy.
Cardiac Myosin Activation with Gene Therapy Produces Sustained Inotropic Effects and May Treat Heart Failure with Reduced Ejection Fraction.
Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure.
Cardiac Myosin Activator Omecamtiv Mecarbil Improves Left Ventricular Myocardial Deformation in Chronic Heart Failure: The COSMIC-HF Trial.
Cardiac myosin activators for heart failure therapy: focus on omecamtiv mecarbil.
Cardiac Myosin Activators for the Treatment of Heart Failure: Stop Now or Push Ahead?
Cardiac myosin and congestive heart failure in the dog.
Cardiac myosin-Th17 responses promote heart failure in human myocarditis.
Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions.
Cardiomyopathy in transgenic myf5 mice.
Cardiomyopathy mutations impact the actin-activated power stroke of human cardiac myosin.
Chagas' disease: polyspecificity of antibodies against Trypanosoma cruzi acidic antigens.
Changes in contractile and non-contractile proteins, intracellular Ca2+ and ultrastructures during the development of right ventricular hypertrophy and failure in rats.
Changes in myofibrillar protein composition of human diaphragm elicited by congestive heart failure.
Changes in skeletal muscle myosin heavy chain isoform content during congestive heart failure.
Characterization of cardiac hypertrophy and heart failure due to volume overload in the rat.
Chemical characterization of cardiac myosin from normal dogs and from dogs with chronic congestive heart failure.
Chronic congestive heart failure elicits adaptations of endurance exercise in diaphragmatic muscle.
Chronic heart failure decreases cross-bridge kinetics in single skeletal muscle fibres from humans.
Chronic heart failure-induced skeletal muscle atrophy, necrosis, and changes in myogenic regulatory factors.
Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure (COSMIC-HF): a phase 2, pharmacokinetic, randomised, placebo-controlled trial.
Circulating concentrations of cardiac proteins indicate the severity of congestive heart failure.
Circulating levels of myocardial proteins predict future deterioration of congestive heart failure.
CK-1827452, a sarcomere-directed cardiac myosin activator for acute and chronic heart disease.
Clinical trials update from Heart Rhythm 2008 and Heart Failure 2008: ATHENA, URGENT, INH study, HEART and CK-1827452.
Clinical trials update from the Heart Failure Society of America meeting: FIX-CHF-4, selective cardiac myosin activator and OPT-CHF.
cMyBPC phosphorylation modulates the effect of omecamtiv mecarbil on myocardial force generation.
Coexistence of mitochondrial DNA and beta myosin heavy chain mutations in hypertrophic cardiomyopathy with late congestive heart failure.
Combining New Classes of Drugs for HFrEF: from Trials to Clinical Practice.
Comprehensive in vitro pro-arrhythmic assays demonstrate that omecamtiv mecarbil has low pro-arrhythmic risk.
Congenital myopathies are mainly associated with a mild cardiac phenotype.
Current concepts in clinical therapeutics: congestive heart failure.
Cytokines that regulate autoimmune myocarditis.
Diagnostic and Prognostic Value of Plasma Levels of Cardiac Myosin Binding Protein-C as a Novel Biomarker in Heart Failure.
Diaphragm single-fiber weakness and loss of myosin in congestive heart failure rats.
Differences in myosin isoform expression in the subepicardial and subendocardial myocardium during cardiac hypertrophy in the rat.
Differential effects of exercise training in men and women with chronic heart failure.
Dilated cardiomyopathy mutation in the converter domain of human cardiac myosin alters motor activity and response to omecamtiv mecarbil.
Direct Myosin Activation by Omecamtiv Mecarbil for Heart Failure with Reduced Ejection Fraction.
Dose-dependent electrophysiological effects of the myosin activator omecamtiv mecarbil in canine ventricular cardiomyocytes.
Down-regulation of MyoD gene expression in rat diaphragm muscle with heart failure.
Downregulation of myogenic microRNAs in sub-chronic but not in sub-acute model of daunorubicin-induced cardiomyopathy.
Effect of Ejection Fraction on Clinical Outcomes in Patients Treated With Omecamtiv Mecarbil in GALACTIC-HF.
Effect of heart failure on skeletal muscle myofibrillar protein content, isoform expression and calcium sensitivity.
Effect of Omecamtiv Mecarbil on the Pharmacokinetics of Metformin, a Probe Substrate for MATE1/MATE2-K, in Healthy Subjects.
Effect of sodium deprivation on cardiac hypertrophy in spontaneously hypertensive rats: influence of aging.
Effect of Varying Degrees of Hepatic Impairment on the Pharmacokinetics of Omecamtiv Mecarbil.
Effect of Varying Degrees of Renal Impairment on the Pharmacokinetics of Omecamtiv Mecarbil.
Effects of danicamtiv, a novel cardiac myosin activator, in heart failure with reduced ejection fraction: experimental data and clinical results from a phase 2a trial.
Effects of induced hyperthyroidism in normal and cardiomyopathic hamsters.
Effects of myosin heavy chain manipulation in experimental heart failure.
Effects of omecamtiv mecarbil on calcium-transients and contractility in a translational canine myocyte model.
Effects of Omecamtiv Mecarbil on Symptoms and Health-Related Quality of Life in Patients With Chronic Heart Failure: Results From the COSMIC-HF Study.
Elevated intraoperative expression of ventricular myosin light chain predicts heart failure after valve replacement surgery.
Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector.
Evaluation of drug-drug interaction potential between omecamtiv mecarbil and rosuvastatin, a BCRP substrate, with a clinical study in healthy subjects and using a physiologically-based pharmacokinetic model.
Fish oil selectively improves heart function in a mouse model of lipid-induced cardiomyopathy.
Frequency-dependent effects of omecamtiv mecarbil on cell shortening of isolated canine ventricular cardiomyocytes.
From Bench to Bedside: New Approaches to Therapeutic Discovery for Heart Failure.
From Genetic Mutations to Molecular Basis of Heart Failure Treatment: An Overview of the Mechanism and Implication of the Novel Modulators for Cardiac Myosin.
Functional consequences of sarcomeric protein abnormalities in failing myocardium.
G protein-coupled receptor kinases 2 and 5 are differentially expressed in rat skeletal muscle and remain unchanged following beta2-agonist administration.
Glycosylation and cross-linkage of cardiac myosin in diabetic subjects: a post-mortem study.
Heart failure alters MyoD and MRF4 expressions in rat skeletal muscle.
Heart failure drug changes the mechanoenzymology of the cardiac myosin powerstroke.
Heart Failure Drug Modifies the Intrinsic Dynamics of the Pre-Power Stroke State of Cardiac Myosin.
Heart failure-induced diaphragm myopathy.
Heart failure-induced skeletal myopathy in spontaneously hypertensive rats.
Heart failure-potential new targets for therapy.
Heart failure.
Heart failure: Cardiac myosin activator shows promise in phase II trial.
Heavy long-term ethanol consumption induces an alpha- to beta-myosin heavy chain isoform transition in rat.
Hemodynamics and mitochondrial energy metabolism in right heart hypertrophy after acute hypoxic stress.
HFpEF, a Disease of the Vasculature: A Closer Look at the Other Half.
How phosphorylated can it get? Cardiac myosin binding protein C phosphorylation in heart failure.
Human atrial myosin light chain 1 expression attenuates heart failure.
Human cardiac myosin heavy chain isoforms in fetal and failing adult atria and ventricles.
Impaired myosin isoform shift and calcium transients contribute to cellular pathogenesis of rat cirrhotic cardiomyopathy.
Improved exercise tolerance after losartan and enalapril in heart failure: correlation with changes in skeletal muscle myosin heavy chain composition.
Improvement of cardiac function by a cardiac Myosin activator in conscious dogs with systolic heart failure.
Increased Ca(2+) -sensitivity of myofibrillar tension in ischemic versus dilated cardiomyopathy.
Increased myosin heavy chain-beta with atrial expression of ventricular light chain-2 in canine cardiomyopathy.
Induction by left ventricular overload and left ventricular failure of the human Jumonji gene (JARID2) encoding a protein that regulates transcription and reexpression of a protective fetal program.
Inhibition of Smooth Muscle Myosin as a Novel Therapeutic Target for Hypertension.
Inotropes in cardiac patients: update 2011.
Left ventricular performance and remodeling in rabbits after myocardial infarction. Effects of a thyroid hormone analogue.
Liver-Specific siRNA-Mediated Stat3 or C3 Knockdown Improves the Outcome of Experimental Autoimmune Myocarditis.
Long-term outcome of 4 Korean families with hypertrophic cardiomyopathy caused by 4 different mutations.
Losartan decreases p42/44 MAPK signaling and preserves LZ+ MYPT1 expression.
Losartan inhibits myosin isoform shift after myocardial infarction in rats.
Maximal actomyosin ATPase activity and in vitro myosin motility are unaltered in human mitral regurgitation heart failure.
Mechanisms underlying skeletal muscle weakness in human heart failure: alterations in single fiber myosin protein content and function.
Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil.
Modulation of cardiac performance by motor protein gene transfer.
Multidimensional structure-function relationships in human ?-cardiac myosin from population-scale genetic variation.
Myocardial infarction, heart failure and sympathetic nervous system activity: new pharmacological approaches that affect neurohumoral activation.
Myosin from failing and non-failing human ventricles exhibit similar contractile properties.
Myosin heavy chain expression and atrophy in rat skeletal muscle during transition from cardiac hypertrophy to heart failure.
Myosin heavy chain gene expression in human heart failure.
Myosin heavy chain synthesis during the progression of chronic tachycardia induced heart failure in rabbits.
Myosin heavy chain synthesis is increased in a rabbit model of heart failure.
Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy.
Myosin structure, allostery, and mechano-chemistry.
Myosin synthesis in chronic heart failure.
New diagnostic and therapeutic possibilities for diastolic heart failure.
New perspective in heart failure management: could myosin activators be the answer?
Novel cardiac myosin activators for acute heart failure.
Novel markers for heart failure diagnosis and prognosis.
Novel therapies in acute and chronic heart failure.
Obesity-associated cardiac pathogenesis in broiler breeder hens: Development of metabolic cardiomyopathy2,3.
Omecamtiv mecarbil activates ryanodine receptors from canine cardiac but not skeletal muscle.
Omecamtiv mecarbil attenuates length-tension relationship in healthy rat myocardium and preserves it in monocrotaline-induced pulmonary heart failure.
Omecamtiv mecarbil does not prolong QTc intervals at therapeutic concentrations.
Omecamtiv Mecarbil in Chronic Heart Failure with Reduced Ejection Fraction, GALACTIC-HF: Baseline Characteristics and Comparison with Contemporary Clinical Trials.
Omecamtiv mecarbil: a new cardiac myosin activator for the treatment of heart failure.
Omecamtiv Mecarbil: A Novel Mechanistic and Therapeutic Approach to Chronic Heart Failure Management.
Opposite diastolic effects of omecamtiv mecarbil versus dobutamine and ivabradine co-treatment in pigs with acute ischemic heart failure.
Overt expression of AP-1 reduces alpha myosin heavy chain expression and contributes to heart failure from chronic volume overload.
Oxidative stress of myosin contributes to skeletal muscle dysfunction in rats with chronic heart failure.
Peroxynitrite inhibits myofibrillar protein function in an in vitro assay of motility.
Pharmacokinetic Drug-Drug Interaction Study of Omecamtiv Mecarbil With Omeprazole, a Proton Pump Inhibitor, in Healthy Subjects.
Pharmacokinetic Evaluation of the CYP3A4 and CYP2D6 Drug-Drug Interaction and CYP3A4 Induction Potential of Omecamtiv Mecarbil: Two Open-Label Studies in Healthy Subjects.
Pharmacokinetics, Disposition, and Biotransformation of [14C]Omecamtiv Mecarbil in Healthy Male Subjects after a Single Intravenous or Oral Dose.
Pharmacokinetics, Tolerability, and Safety of Single and Multiple Omecamtiv Mecarbil Doses in Healthy Japanese and Caucasian Subjects.
Pilot study identifying myosin heavy chain 7, desmin, insulin-like growth factor 7, and annexin A2 as circulating biomarkers of human heart failure.
Plasmid-based transient human stromal cell-derived factor-1 gene transfer improves cardiac function in chronic heart failure.
Population pharmacokinetic-pharmacodynamic modeling of omecamtiv mecarbil, a cardiac myosin activator, in healthy volunteers and patients with stable heart failure.
Possible involvement of microRNAs (miR-135a?) in heart failure associated with 25bp deletion in MYBPC3 (cardiac myosin binding protein C) gene.
Proteasome inhibition improves diaphragm function in congestive heart failure rats.
Random myosin loss along thick-filaments increases myosin attachment time and the proportion of bound myosin heads to mitigate force decline in skeletal muscle.
Reduced cardiac myofibrillar Mg-ATPase activity without changes in myosin isozymes in patients with end-stage heart failure.
Reduced cardiac myosin adenosinetriphosphatase activity in dogs with spontaneously occurring heart failure.
Relation of circulating cardiac myosin light chain 1 isoform in stable severe congestive heart failure to survival and treatment with flosequinan.
Relative Bioavailability of Omecamtiv Mecarbil Pediatric Minitablet Formulations in Healthy Adult Subjects.
Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy.
Ribonucleotide reductase-mediated increase in dATP improves cardiac performance via myosin activation in a large animal model of heart failure.
Role of actin and myosin in the mechanism of the decrease of myocardial contractility and efficiency of energy transformation by myocardial myofibrils in chronic heart failure in humans.
Sarcomere protein gene mutations and inherited heart disease: a beta-cardiac myosin heavy chain mutation causing endocardial fibroelastosis and heart failure.
Skeletal muscle contractile protein function is preserved in human heart failure.
Skeletal muscle molecular alterations precede whole-muscle dysfunction in NYHA Class II heart failure patients.
Skeletal muscle myofibrillar mRNA expression in heart failure: relationship to local and circulating hormones.
Skeletal muscle myofibrillar protein metabolism in heart failure: relationship to immune activation and functional capacity.
Skeletal muscle myofibrillar protein oxidation and exercise capacity in heart failure.
Skeletal muscle myofibrillar protein oxidation in heart failure and the protective effect of Carvedilol.
Skeletal muscle myosin heavy chains in heart failure: correlation between magnitude of the isozyme shift, exercise capacity, and gas exchange measurements.
Skeletal Single Muscle Fiber Myosin Heavy Chain Composition and IGF-1 mRNA Expression with Heart Failure: 669: May 31 8:45 AM 9:00 AM.
Slow Cardiac Myosin Regulatory Light Chain 2 (MYL2) was Down-Expressed in Chronic Heart Failure Patients.
Slow cardiac myosin regulatory light chain 2 (MYL2) was down-expressed in chronic heart failure patients.
Specific changes in skeletal muscle myosin heavy chain composition in cardiac failure: differences compared with disuse atrophy as assessed on microbiopsies by high resolution electrophoresis.
Studies of actomyosin from cardiac muscle of dogs with experimental congestive heart failure.
Subclass specificity of autoantibodies against myosin in patients with idiopathic dilated cardiomyopathy: pro-inflammatory antibodies in DCM patients.
Superprecipitation of hybrid actomyosin containing pathologic actin from failing hearts of adults and infants.
Switchability and minimal effect of food on pharmacokinetics of modified release tablet strengths of omecamtiv mecarbil, a cardiac myosin activator.
Synthesis and 18F-labeling of the analogues of Omecamtiv Mecarbil as a potential cardiac myosin imaging agent with PET.
The amino acid composition of actin and myosin and Ca2+-activated myosin adenosine triphosphatase in chronic canine congestive heart failure.
The effect of moderate exercise training on skeletal muscle myosin heavy chain distribution in chronic heart failure.
The Ku protein complex interacts with YY1, is up-regulated in human heart failure, and represses alpha myosin heavy-chain gene expression.
The Murine Model of Mucopolysaccharidosis IIIB Develops Cardiopathies over Time Leading to Heart Failure.
The potential role of MLC phosphatase and MAPK signalling in the pathogenesis of vascular dysfunction in heart failure.
The slow cardiac Myosin regulatory light chain in heart failure.
The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans.
Thick filament proteins and performance in human heart failure.
Translation of Cardiac Myosin Activation with 2-deoxy-ATP to Treat Heart Failure via an Experimental Ribonucleotide Reductase-Based Gene Therapy.
Ventricular fibrillation following autologous intramyocardial cell therapy for inherited cardiomyopathy.
[A disorder of myocardial contractile function in acute experimental coronary failure: the submolecular mechanisms and the action of cardiac glycosides]
[Autoantibodies: new upstream targets of paroxysmal atrial fibrillation in patients with congestive heart failure]
[Cardiomyocyte myosin heavy chain composition change after cryptosporidial gastroenteritis].
[Effects of Salvianolate on Myosin Heavy Chain in Cardiomyocytes of Congestive Heart Failure Rats].
[Mid-term prognostic value of plasma heavy-chain myosin in thrombolysed myocardial infarction]
[Myosin isoforms in skeletal muscle in patients with chronic heart decompensation: distribution and correlation with with exercise tolerance]
[Structural and functional changes in myosin in chronic coronary insufficiency]
[The advances of research for cardiac contractile proteins structure and function]
[The prognostic value of type-1 myosin heavy chain in the skeletal muscle of patients with chronic heart failure of a mild-moderate degree]
Heart Failure, Diastolic
Cardiac myosin binding protein C and MAP-kinase activating death domain-containing gene polymorphisms and diastolic heart failure.
Heart Failure, Systolic
A New Approach to Inotropic Therapy in the Treatment of Heart Failure: Cardiac Myosin Activators.
Cardiac Myosin Activation for the Treatment of Systolic Heart Failure.
Cardiac myosin activation part 1: From concept to clinic.
Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure.
Cardiac myosin activation: a potential therapeutic approach for systolic heart failure.
Cardiac Myosin Activators in Systolic Heart Failure: More Friend than Foe?
Design and synthesis of sulfonamidophenylethylamides as novel cardiac myosin activator.
Design and synthesis of sulfonamidophenylethylureas as novel cardiac myosin activator.
Effects of omecamtiv mecarbil on failing human ventricular trabeculae and interaction with (-)-noradrenaline.
Exploration of flexible phenylpropylurea scaffold as novel cardiac myosin activators for the treatment of systolic heart failure.
Identification of diphenylalkylisoxazol-5-amine scaffold as novel activator of cardiac myosin.
Improvement of cardiac function by a cardiac Myosin activator in conscious dogs with systolic heart failure.
Molecular mechanisms underlying deoxy-ADP.Pi activation of pre-powerstroke myosin.
Myosin Modulation in Hypertrophic Cardiomyopathy and Systolic Heart Failure: Getting Inside the Engine.
Myosin Modulators: The New Era of Medical Therapy for Systolic Heart Failure and Hypertrophic Cardiomyopathy.
Omecamtiv Mecarbil Slows Myosin Kinetics in Skinned Rat Myocardium at Physiological Temperature.
Structural basis for drug-induced allosteric changes to human ?-cardiac myosin motor activity.
Targeted and Controlled Drug Delivery to a Rat Model of Heart Failure Through a Magnetic Nanocomposite.
The effect of the cardiac myosin activator, omecamtiv mecarbil, on right ventricular structure and function in chronic systolic heart failure (COSMIC-HF).
The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial.
The novel cardiac myosin activator omecamtiv mecarbil increases the calcium sensitivity of force production in isolated cardiomyocytes and skeletal muscle fibres of the rat.
Heart Septal Defects, Atrial
Cardiac troponin T is necessary for normal development in the embryonic chick heart.
Mutation in myosin heavy chain 6 causes atrial septal defect.
Heart Septal Defects, Ventricular
Expression of ventricular myosin subunits in the atria of children with congenital heart malformations.
Heart Valve Diseases
Increased calcium sensitivity of chemically skinned human atria by myosin light chain kinase.
Induction of myocarditis and valvulitis in lewis rats by different epitopes of cardiac myosin and its implications in rheumatic carditis.
Pathology and pathogenesis of rheumatic heart disease.
Relationship between the myofibrillar ATPase activity of human biopsy material and hemodynamic parameters.
[Changes in the composition of cardiac muscle myosin light chains during cardiac diseases].
Hemangioma
Immunohistochemical evaluation of factor VIII related antigen, filament proteins and lectin binding in haemangiomas.
Hemangioma, Cavernous, Central Nervous System
CCM2 and PAK4 act downstream of atrial natriuretic peptide signaling to promote cell spreading.
Hematologic Neoplasms
Targeting Actomyosin Contractility Suppresses Malignant Phenotypes of Acute Myeloid Leukemia Cells.
Hemiplegia
Disuse of anterior tibial muscle during locomotion and increased proportion of type II fibres in hemiplegia.
Hemophilia A
Novel exomic rare variants associated with venous thrombosis.
Hepatitis
A novel combination of promoter and enhancers increases transgene expression in vascular smooth muscle cells in vitro and coronary arteries in vivo after adenovirus-mediated gene transfer.
Anti-smooth muscle antibodies (ASMAs) and anti-cytoskeleton antibodies (ACTAs) in liver diseases: a comparison of classical indirect immunofluorescence with ELISA.
Human CMV immediate-early enhancer: a useful tool to enhance cell-type-specific expression from lentiviral vectors.
Reaction of hepatitis antisera with actomyosin.
Sera with high levels of anti-smooth muscle and anti-mitochondrial antibodies frequently bind to cytoskeleton proteins.
Hepatitis B
Autoantibodies and circulating immune complexes in sera from patients with hepatitis B virus-related chronic liver disease.
Immunohistological investigations of PAS-negative globular intracisternal hyalin in human liver biopsy specimens.
Hepatitis C
Life without double-headed non-muscle myosin II motor proteins.
Non-muscle myosin as target antigen for human autoantibodies in patients with hepatitis C virus-associated chronic liver diseases.
Hepatitis, Chronic
Sera with high levels of anti-smooth muscle and anti-mitochondrial antibodies frequently bind to cytoskeleton proteins.
Hermanski-Pudlak Syndrome
Analysis of platelet cytoskeleton assembly during platelet activation in Hermansky-Pudlak syndrome and thrombasthenia.
Hernias, Diaphragmatic, Congenital
Effect of nitrofen in the final stages of development of the diaphragm muscle in rats.
Myocardium expression of connexin 43, SERCA2a, and myosin heavy chain isoforms are preserved in nitrofen-induced congenital diaphragmatic hernia rat model.
Pulmonary expression of vascular endothelial growth factor and myosin isoforms in rats with congenital diaphragmatic hernia.
Herpes Simplex
Distribution of actin and myosin in a rat neuronal cell line infected with herpes simplex virus.
Evidence of a role for nonmuscle myosin II in herpes simplex virus type 1 egress.
Myosin Va enhances secretion of herpes simplex virus 1 virions and cell surface expression of viral glycoproteins.
Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1.
Nonmuscle myosin heavy chain IIb mediates herpes simplex virus 1 entry.
Organization of cytoskeleton elements during herpes simplex virus type 1 infection of human fibroblasts: an immunofluorescence study.
Herpes Zoster
Characterization of epithelial cell shedding from human small intestine.
Localization of actin and myosin in the rat oocyte and follicular wall by immunofluorescence.
MiRNA-155-5p Reduces Corneal Epithelial Permeability by Remodeling Epithelial Tight Junctions during Corneal Wound Healing.
The Traditional Chinese Medicine Compound, GRS, Alleviates Blood-Brain Barrier Dysfunction.
Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways.
Hirschsprung Disease
Novel smooth muscle markers reveal abnormalities of the intestinal musculature in severe colorectal motility disorders.
Histiocytoma, Benign Fibrous
Expression of desmin and smooth muscle myosin heavy chain in dermatofibromas.
Histiocytoma, Malignant Fibrous
Smooth and skeletal muscle myosins in spindle cell tumors of soft tissue. An immunohistochemical study.
Hoarseness
Variable phenotypic expression and onset in MYH14 distal hereditary motor neuropathy phenotype in a large, multigenerational North American family.
Hodgkin Disease
miR-155 regulates HGAL expression and increases lymphoma cell motility.
Huntington Disease
Fast-to-Slow Transition of Skeletal Muscle Contractile Function and Corresponding Changes in Myosin Heavy and Light Chain Formation in the R6/2 Mouse Model of Huntington's Disease.
Hydrocephalus
A proteomics approach to characterizing human submandibular gland cell lines by fluorescent two-dimensional differential in-gel electrophoresis.
Loss of cell adhesion causes hydrocephalus in nonmuscle myosin II-B-ablated and mutated mice.
Myosin IXa Regulates Epithelial Differentiation and Its Deficiency Results in Hydrocephalus.
Structural abnormalities develop in the brain after ablation of the gene encoding nonmuscle myosin II-B heavy chain.
Hyperglycemia
Altered myosin light-chain phosphorylation in resting platelets from premenopausal women with diabetes.
Maternal hyperglycemia leads to fetal cardiac hyperplasia and dysfunction in a rat model.
The effect of streptozotocin-induced diabetes in rats on cardiac contractile proteins.
Zinc-induced cardiomyocyte relaxation in a rat model of hyperglycemia is independent of myosin isoform.
Hyperinsulinism
Impact of hyperinsulinemia on myosin heavy chain gene regulation.
Hyperlipidemias
Involvement of NADPH oxidases and non-muscle myosin light chain in senescence of endothelial progenitor cells in hyperlipidemia.
Phosphorylation of Nonmuscle Myosin Light Chain Promotes Endothelial Injury in Hyperlipidemic Rats Through a Mechanism Involving Downregulation of Dimethylarginine Dimethylaminohydrolase 2.
Pyrogallol-Phloroglucinol-6,6-Bieckolon Attenuates Vascular Smooth Muscle Cell Proliferation and Phenotype Switching in Hyperlipidemia through Modulation of Chemokine Receptor 5.
[Molecular biology in cardiovascular medicine]
Hyperlipoproteinemia Type I
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Hyperlipoproteinemia Type II
Distribution of actin, myosin and actin binding protein in platelets of patients with hyperlipoproteinemia.
Hyperlipoproteinemias
Distribution of actin, myosin and actin binding protein in platelets of patients with hyperlipoproteinemia.
Hypersensitivity
Captopril ameliorates myocarditis in acute experimental Chagas disease.
Captopril prevents experimental autoimmune myocarditis.
Cardiac myosin autoimmunity in acute Chagas' heart disease.
Lactobacillus farciminis treatment suppresses stress induced visceral hypersensitivity: a possible action through interaction with epithelial cell cytoskeleton contraction.
Meat allergy.
Myosin heavy chain, a novel allergen for fish allergy in patients with atopic dermatitis.
Nonmuscle myosin IIB links cytoskeleton to IRE1? signaling during ER stress.
Shellfish allergy: unmet needs in diagnosis and treatment.
SM2(+/-) male mice are predisposed to develop urinary tract obstruction and hyper contractility of the bladder smooth muscle upon ageing.
The comprehensive pathophysiological changes in a novel rat model of postinflammatory visceral hypersensitivity.
The role of the adrenal cortex in human essential hypertension: keynote address.
[Autoimmune changes in various rheumatic diseases]
Hypersensitivity, Delayed
[Cytotoxic effect of the lymphocytes in ischemic heart disease]
[Delayed hypersensitivity in rheumatism studied using human cardiac myosin]
Hypertension
Adaptation of cardiac myosin and creatine kinase to chronic hypoxia: role of anorexia and hypertension.
Age dependent changes in myosin ATPase activity in the myocardium of spontaneously hypertensive rats.
Age-related difference in cardiac adaptation to chronic hypertension in rats, with and without nifedipine treatment.
Alterations in cardiac myosin isozymes associated with aging and chronic hypertension: their modulation with nifedipine.
Altered expression of troponin T isoforms in mild left ventricular hypertrophy in the rabbit.
Arterial muscle myosin heavy chains and light chains in spontaneous hypertension.
Association of MYH9 Polymorphisms with Hypertension in Patients with Chronic Kidney Disease in China.
Chronic hypertension changes myosin isoenzyme pattern and decreases myosin phosphorylation in the rat heart.
Chronic swimming reverses cardiac dysfunction and myosin abnormalities in hypertensive rats.
Complete cDNA sequence of rat atrial myosin light chain 1: patterns of expression during development and with hypertension.
Correlation between total catecholamine content and redistribution of myosin isoenzymes in pressure loaded ventricular myocardium of the spontaneously hypertensive rat.
Correlation of myosin heavy chain expression in the rat with cAMP in different models of hypertension-induced cardiac hypertrophy.
Dietary omega-3 fatty acids attenuate myocardial arrhythmogenic factors and propensity of the heart to lethal arrhythmias in a rodent model of human essential hypertension.
Differential roles of AT1 and AT2 receptor subtypes in vascular trophic and phenotypic changes in response to stimulation with angiotensin II.
Dissociation of cardiac hypertrophy, myosin heavy chain isoform expression, and natriuretic peptide production in DOCA-salt rats.
Effect of aging and hypertension on myosin biochemistry and gene expression in the rat heart.
Effect of antihypertensive treatment on the left ventricular isomyosin profile in one-clip, two kidney hypertensive rats.
Effect of swimming training on cardiac function and myosin ATPase activity in SHR.
Effects of bunitrolol on myocardial contractility and left ventricular myosin isoenzyme pattern.
Effects of chronic dobutamine administration on hearts of normal and hypertensive rats.
Effects of lipopolysaccharide on vascular reactivity and mortality in rats.
Endothelial contractility - an undecided problem in vascular research.
Essential hypertension and risk of nephropathy: a reappraisal.
Factors regulating myocardial hypertrophy in hypertension.
Fiber type populations and Ca2+-activation properties of single fibers in soleus muscles from SHR and WKY rats.
Genome-wide linkage analysis of serum creatinine in three isolated European populations.
High-sugar diets increase cardiac dysfunction and mortality in hypertension compared to low-carbohydrate or high-starch diets.
Humoral factor(s) produced by pressure overload enhance cardiac hypertrophy and natriuretic peptide expression.
Identification of Genetic Factors Underlying the Association between Sodium Intake Habits and Hypertension Risk.
Implications of myocardial transformation for cardiac energetics.
Increased rat myocardial type VI collagen in diabetes mellitus and hypertension.
Influence of long-term arotinolol treatment on myocardial mechanics and ventricular myosin isoenzymes in spontaneously hypertensive rats.
Inhibition of Smooth Muscle Myosin as a Novel Therapeutic Target for Hypertension.
Intracellular signal transduction for vasoactive peptides in hypertension.
Involvement of Ras-regulated myosin light chain phosphorylation in the captopril effects in spontaneously hypertensive rats.
Isomyosin distribution in normal and pressure-overloaded rat ventricular myocardium. An immunohistochemical study.
Left ventricular regional variations in myosin isoform shift in Dahl salt-sensitive hypertensive rats.
Molecular mechanisms of neuronal nitric oxide synthase in cardiac function and pathophysiology.
Myosin cross-bridge dynamics in patients with hypertension and concentric left ventricular remodeling.
Non-muscle myosin light chain promotes endothelial progenitor cells senescence and dysfunction in pulmonary hypertensive rats through up-regulation of NADPH oxidase.
Physiologic cardiac hypertrophy corrects contractile protein abnormalities associated with pathologic hypertrophy in rats.
Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans.
Preventive training does not interfere with mRNA-encoding myosin and collagen expression during pulmonary arterial hypertension.
Radiotelemetric characterization of overweight-associated rises in blood pressure and heart rate.
Redistribution of myosin VI from top to base of proximal tubule microvilli during acute hypertension.
Regulation of antisense RNA expression during cardiac MHC gene switching in response to pressure overload.
RNA editing of Filamin A pre-mRNA regulates vascular contraction and diastolic blood pressure.
Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II.
Src Family Kinases (SFK) Mediate Angiotensin II-Induced Myosin Light Chain Phosphorylation and Hypertension.
The influence of cold stress on the myosin heavy chain expression of cardiac and smooth muscle in normotensive and spontaneously hypertensive female rats.
The potential role of myosin motor proteins in mediating the subcellular distribution of NHE3 in the renal proximal tubule.
Troponin T switching in the developing rat heart.
Vascular changes in DOCA hypertension. Influence of a low protein diet.
Ventricular myosin light chain 1 is developmentally regulated and does not change in hypertension.
ZIP kinase, a key regulator of myosin protein phosphatase 1.
[Autoantibodies: new upstream targets of paroxysmal atrial fibrillation in patients with congestive heart failure]
[Changes in heart genome expression in hypertensive diseases]
[Changes in ventricular myosin in 2 different models of arterial hypertension]
[Changes of cardiac myosin in spontaneously hypertensive rats and control rats, during the various stages of development of essential arterial hypertension]
[Fractional composition of myocardial proteins and the adenosine triphosphate activity of myosin in hypertension and coronary atherosclerosis]
Hypertension, Portal
Blebbistatin inhibits contraction and accelerates migration in mouse hepatic stellate cells.
Distinct roles for non-muscle myosin II isoforms in mouse hepatic stellate cells.
Impaired agonist-dependent myosin phosphorylation and decreased RhoA in rat portal hypertensive mesenteric vasculature.
Hypertension, Pulmonary
Changes in myosin heavy chain and its localization in rat heart in association with hypobaric hypoxia-induced pulmonary hypertension.
Different biventricular remodelling of myosin and collagen in pulmonary hypertension.
Microvessel precursor smooth muscle cells express head-inserted smooth muscle myosin heavy chain (SM-B) isoform in hyperoxic pulmonary hypertension.
Rho kinase-mediated vasoconstriction in pulmonary hypertension.
Smooth muscle myosin inhibition: a novel therapeutic approach for pulmonary hypertension.
Hypertension, Renal
Characteristics of arterial myosin in experimental renal hypertension in the dog.
Chronic swimming reverses cardiac dysfunction and myosin abnormalities in hypertensive rats.
Inhibition of Smooth Muscle Myosin as a Novel Therapeutic Target for Hypertension.
Mechanisms behind myocardial depression in rat renal hypertension.
Myocardial changes during the progression of left ventricular pressure-overload by renal hypertension or aortic constriction: myosin, myosin ATPase and collagen.
Hypertension, Renovascular
Alterations in gene expression in the rat heart after chronic pathological and physiological loads.
Altered Ca2+ dynamics in single cardiac myocytes from renovascular hypertensive rats.
Effects of regression of cardiac hypertrophy on myocardial contractility and ventricular myosin isoenzymes.
Effects of systolic overload and swim training on cardiac mechanics and biochemistry in rats.
Hyperthyroidism
2,3-Butanedione monoxime increases contractile efficiency in the rabbit ventricle.
All members of the MHC multigene family respond to thyroid hormone in a highly tissue-specific manner.
Antagonistic effects of chronic low frequency stimulation and thyroid hormone on myosin expression in rat fast-twitch muscle.
Aortic intimal thickening and myosin isoform expression in hyperthyroid rabbits.
Biochemical and morphological study of cardiac hypertrophy. Effects of thyroxine on enzyme activities in the rat myocardium.
Carbonylation of atrial myosin prolongs its interaction with actin.
Changes in myosin isozyme expression during cardiac hypertrophy in hyperthyroid rabbits.
Changes in skeletal muscle protein metabolism and myosin heavy chain isoform messenger ribonucleic acid abundance after treatment of hyperthyroidism.
Comparative studies of atrial and ventricular myosin from normal, thyrotoxic, and thyroidectomized rabbits.
Comparison of myosin heavy chains in atria and ventricles from hyperthyroid, hypothyroid, and euthyroid rabbits.
Competitive control of myosin expression: hypertrophy vs. hyperthyroidism.
Contractility and myosin isoform compositions of skeletal muscles and muscle cells from rats treated with thyroid hormone for 0, 4 and 8 weeks.
Coordinated fast-to-slow transitions of myosin and SERCA isoforms in chronically stimulated muscles of euthyroid and hyperthyroid rabbits.
Cross-bridge and calcium behavior in ferret papillary muscle in different thyroid states.
Decreased contractile efficiency and increased nonmechanical energy cost in hyperthyroid rabbit heart. Relation between O2 consumption and systolic pressure-volume area or force-time integral.
Different time course of changes in sarcoplasmic reticulum and myosin isoforms in rat soleus muscle at early stage of hyperthyroidism.
Distribution of myosin heavy chain mRNA in normal and hyperthyroid heart.
Effect of hyperthyroidism on the orbicularis oculi muscle in rabbits.
Effect of the thyroid state on the enzymatic characteristics of cardiac myosin. A difference in behavior of rat and rabbit cardiac myosin.
Effect of thyroid state on cardiac myosin P-light chain phosphorylation during exercise.
Energetics of isometric force development in control and volume-overload human myocardium. Comparison with animal species.
Expression of rabbit ventricular alpha-myosin heavy chain messenger RNA sequences in atrial muscle.
Fiber-specific regulation of Ca(2+)-ATPase isoform expression by thyroid hormone in rat skeletal muscle.
Hormonal influences on cardiac myosin ATPase activity and myosin isoenzyme distribution.
Hyperthyroid dog left ventricle has the same oxygen consumption versus pressure-volume area (PVA) relation as euthyroid dog.
Immunological and biochemical evidence for atrial-like isomyosin in thyrotoxic rabbit ventricle.
Influence of hyperthyroidism on glycerol-extracted cardiac muscle from rabbits.
Influence of hyperthyroidism on maximal shortening velocity and myosin isoform distribution in skeletal muscles.
Influence of hyperthyroidism on the superprecipitation response and Ca2+-sensitivity of natural actomyosin in cardiac and skeletal muscle.
Influence of the thyroid state on myocardial myosin in the adult pig heart.
Influence of thyroid status on the differentiation of slow and fast muscle phenotypes.
Interaction of hyperthyroidism and hindlimb suspension on skeletal myosin heavy chain expression.
Isolation and characterization of two molecular variants of myosin heavy chain from rabbit ventricle. Change in their content during normal growth and after treatment with thyroid hormone.
Kinetic comparison of normal and thyrotoxic bovine cardiac myosin subfragment-1.
Local diversity of myosin expression in mammalian atrial muscles. Variations depending on age and thyroid state in the rat and the rabbit.
Modulation by the thyroid state of intracellular calcium and contractility in ferret ventricular muscle.
Molecular defects in cardiac myofibrillar proteins due to thyroid hormone imbalance and diabetes.
Myosin and SERCA isoform expression in denervated slow-twitch muscle of euthyroid and hyperthyroid rabbits.
Myosin heavy chain of immature soleus muscle grafts adapts to hyperthyroidism more than to physical activity.
Novel transitions in MHC isoforms: separate and combined effects of thyroid hormone and mechanical unloading.
Oxidation of myosin heavy chain and reduction in force production in hyperthyroid rat soleus.
Reconstitution of heavy chain and light chain 1 in cardiac subfragment-1 from hyperthyroid and euthyroid rabbit hearts.
Recovery after cardioplegia in the hypertrophic rat heart.
Regulation by thyroid hormones of terminal differentiation in the skeletal dorsal muscle. I. Neonate mouse.
Single fiber analyses of type IIA myosin heavy chain distribution in hyper- and hypothyroid soleus.
Sliding velocity of isolated rabbit cardiac myosin correlates with isozyme distribution.
Slow-to-fast transitions in myosin expression of rat soleus muscle by phasic high-frequency stimulation.
The dual effect of thyroid hormones on contractile properties of rat myocardium.
The Effect of Experimental Hyperthyroidism on Characteristics of Actin-Myosin Interaction in Fast and Slow Skeletal Muscles.
The influence of thyroid hormone on myosin isoform composition and shortening velocity of single skeletal muscle fibres with special reference to ageing and gender.
Thyroid hormone effects on contractility and myosin composition of soleus muscle and single fibres from young and old rats.
Thyroid hormone regulation of MHC isoform composition and myofibrillar ATPase activity in rat skeletal muscles.
Thyroid hormone-induced alterations in phospholamban-deficient mouse hearts.
Thyroidal and neural control of myosin transitions during development of rat fast and slow muscles.
Thyroxine-induced cardiomegaly: assessment of nucleic acid, protein content and myosin ATPase of rat heart.
Ventricular and aortic myosin in hypothyroid and hyperthyroid broad breasted white turkeys.
[Cardiac myosins and myocardial contraction]
[Cardiopulmonary involvement in thyroid gland diseases]
Hypertriglyceridemia
Distribution of actin, myosin and actin binding protein in platelets of patients with hyperlipoproteinemia.
Hypertrophy, Left Ventricular
Alterations in cardiac myosin isozymes associated with aging and chronic hypertension: their modulation with nifedipine.
Beta-receptor blockade decreases carnitine palmitoyl transferase I activity in dogs with heart failure.
Cardiac hypertrophy in the ferret increases expression of the Na(+)-K(+)-ATPase alpha 1- but not alpha 3-isoform.
Changes in ventricular myosin properties during broad breasted white turkey (BBWT) development.
Differences in echocardiography, blood pressure, stroke volume, maximal power and profile of genes related to cardiac hypertrophy in elite road cyclists.
Dissociation of left ventricular hypertrophy, beta-myosin heavy chain gene expression, and myosin isoform switch in rats after ascending aortic stenosis.
Effect of antihypertensive treatment on the left ventricular isomyosin profile in one-clip, two kidney hypertensive rats.
Genetic polymorphisms in the renin-angiotensin-aldosterone system associated with expression of left ventricular hypertrophy in hypertrophic cardiomyopathy: a study of five polymorphic genes in a family with a disease causing mutation in the myosin binding protein C gene.
Low carbohydrate/high-fat diet attenuates cardiac hypertrophy, remodeling, and altered gene expression in hypertension.
Myocardial gene expression of microRNA-133a and myosin heavy and light chains, in conjunction with clinical parameters, predict regression of left ventricular hypertrophy after valve replacement in patients with aortic stenosis.
Myosin VI and cardiomyopathy: Left ventricular hypertrophy, fibrosis, and both cardiac and pulmonary vascular endothelial cell defects in the Snell's waltzer mouse.
Prolonged Ca2+ and force transients in myosin RLC transgenic mouse fibers expressing malignant and benign FHC mutations.
Rapid transient analysis of myosin cross-bridge kinetics in hypertrophied hearts.
Regression of cardiac hypertrophy in spontaneously hypertensive rats by enalapril and the expression of contractile proteins.
Relationship between the myofibrillar ATPase activity of human biopsy material and hemodynamic parameters.
Hypertrophy, Right Ventricular
Left ventricular remodelling following experimental myocardial infarction.
Modulation of myosin in right ventricular hypertrophy.
Hypoalphalipoproteinemias
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Hypocalcemia
Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors.
Hypogonadism
The effect of androgen status on skeletal muscle myosin heavy chain mRNA and protein levels in rats recovering from immobilization.
Hypokinesia
Arrest of developmental conversion of type II to type I fibres after suspension hypokinesia.
Myosin subunits and contractile properties of single fibers from hypokinetic rat muscles.
Hypophosphatemia
Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors.
Hypotension
Mechanical and biochemical alterations of aorta induced by hydralazine hypotension.
[Treatment of heart failure patients with inotropic drugs: beyond traditional agents].
Hypothyroidism
A monoclonal antibody to the embryonic myosin heavy chain of rat skeletal muscle.
All members of the MHC multigene family respond to thyroid hormone in a highly tissue-specific manner.
Alterations in phenotypic and contractile properties of the rat diaphragm: influence of hypothyroidism.
Changes in myosin and creatine kinase mRNA levels with cardiac hypertrophy and hypothyroidism.
Comparison of normal, hypodynamic, and hyperdynamic mouse hearts using isolated work-performing heart preparations.
Control of myosin heavy chain expression: interaction of hypothyroidism and hindlimb suspension.
Cyclic AMP regulation of myosin isozymes in mammalian cardiac muscle.
Diabetes mellitus and hypothyroidism induce changes in myosin isoenzyme distribution in the rat heart--do alterations in fuel flux mediate these changes?
Diminished Ca2+ sensitivity of skinned cardiac muscle contractility coincident with troponin T-band shifts in the diabetic rat.
Effect of amiodarone on rat heart myosin isoenzymes.
Effect of diabetes and hypothyroidism on the predominance of cardiac myosin heavy chains synthesized in vivo or in a cell-free system.
Effect of Fetal Hypothyroidism on Cardiac Myosin Heavy Chain Expression in Male Rats.
Effect of hypothyroidism on myosin heavy chain expression in rat pharyngeal dilator muscles.
Effects of exercise on protein synthesis and myosin heavy chain gene expression in hypothyroid rats.
Effects of hypothyroidism on maximum specific force in rat diaphragm muscle fibers.
Effects of hypothyroidism on myosin heavy chain composition and fibre types of fast skeletal muscles in a small marsupial, Antechinus flavipes.
Effects of hypothyroidism on myosin isozyme transitions in developing rat muscle.
Effects of perinatal undernutrition on elimination of immature myosin isoforms in the rat diaphragm.
Evidence for a direct action of thyroid hormone in specifying muscle properties.
Heterogeneity of alpha-cardiac myosin heavy chains in a small marsupial, Antechinus flavipes, and the effect of hypothyroidism on its ventricular myosins.
Hypothyroid-mediated changes in adult rat diaphragm muscle contractile properties and MHC isoform expression.
Hypothyroidism alters diaphragm muscle development.
Induction and stability of the adult myosin phenotype in striated muscles of dwarf mice after chronic thyroid hormone treatment.
Influence of the thyroid state on myocardial myosin in the adult pig heart.
Influence of thyroid hormone administration on myosin ATPase activity and myosin isoenzyme distribution in the heart of diabetic rats.
Long-term amiodarone treatment causes cardioselective hypothyroid-like alteration in gene expression profile.
Modulation by the thyroid state of intracellular calcium and contractility in ferret ventricular muscle.
Molecular defects in cardiac myofibrillar proteins due to thyroid hormone imbalance and diabetes.
Muscle LIM protein is upregulated in fast skeletal muscle during transition toward slower phenotypes.
Quantification of MyoD, myogenin, MRF4 and Id-1 by reverse-transcriptase polymerase chain reaction in rat muscles--effects of hypothyroidism and chronic low-frequency stimulation.
Regulation of an Antisense RNA with the Transition of Neonatal to IIb Myosin Heavy Chain during Postnatal Development and Hypothyroidism in Rat Skeletal Muscle.
Response of slow and fast muscle to hypothyroidism: maximal shortening velocity and myosin isoforms.
Reversible epigenetic modifications of the two cardiac myosin heavy chain genes during changes in expression.
Sarcomeric myosin heavy chain gene family: organization and pattern of expression.
Signaling pathways responsible for fetal gene induction in the failing human heart: evidence for altered thyroid hormone receptor gene expression.
Single-fiber myosin heavy chain polymorphism during postnatal development: modulation by hypothyroidism.
Structural and functional aspects of the actomyosin complex from fast-twitch muscle of euthyroid and hypothyroid rats.
The prevalence of autoantibodies to: myosin, troponin, tropomyosin and myoglobin in patients with circulating triiodothyronine and thyroxine autoantibodies (THAA).
Troponin T switching in the developing rat heart.
Zinc-induced cardiomyocyte relaxation in a rat model of hyperglycemia is independent of myosin isoform.
[Clinical assessment of serum myosin light chain I in patients with dilated cardiomyopathy]
[Serum myosin light chain I concentration in patients with primary hypothyroidism]
Ileus
Hesperidin alleviates rat postoperative ileus through anti-inflammation and stimulation of Ca(2+)-dependent myosin phosphorylation.
Hypertonic saline modulation of intestinal tissue stress and fluid balance.
Infarction, Middle Cerebral Artery
Following OGD/R, Annexin 1 Nuclear Translocation and Subsequent Induction of Apoptosis in Neurons Are Assisted by Myosin IIA in a TRPM7 Kinase-Dependent Manner.
NMMHC IIA triggers neuronal autophagic cell death by promoting F-actin-dependent ATG9A trafficking in cerebral ischemia/reperfusion.
Infections
A "Driver Switchover" Mechanism of Influenza Virus Transport from Microfilaments to Microtubules.
A cardiac myosin-specific autoimmune response is induced by immunization with Trypanosoma cruzi proteins.
A post-invasion role for Chlamydia type III effector TarP in modulating the dynamics and organization of host cell focal adhesions.
A subtype of cerebrovascular pericytes is associated with blood-brain barrier disruption that develops during normal aging and simian immunodeficiency virus infection.
Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes.
Antigenic complementarity between coxsackie virus and streptococcus in the induction of rheumatic heart disease and autoimmune myocarditis.
Autoantibodies to cardiac myosin in mouse cytomegalovirus myocarditis.
Autoimmune myocarditis.
Cardiac myosin autoimmunity in acute Chagas' heart disease.
Cardiac myosin induces myocarditis in genetically predisposed mice.
Caspase activation contributes to endotoxin-induced diaphragm weakness.
Characterization of anti-heart antibodies in mice after infection with coxsackie B3 virus.
Cholangiocyte myosin IIB is required for localized aggregation of sodium glucose cotransporter 1 to sites of Cryptosporidium parvum cellular invasion and facilitates parasite internalization.
Coiled-coil irregularities and instabilities in group A Streptococcus M1 are required for virulence.
Common and unique gene expression signatures of human macrophages in response to four strains of Mycobacterium avium that differ in their growth and persistence characteristics.
Comparative proteomic investigation of Marsupenaeus japonicus hepatopancreas challenged with Vibrio parahaemolyticus and white spot syndrome virus.
Comparison between autoantibodies arising during Trypanosoma cruzi infection in mice and natural autoantibodies.
Coxsackievirus B3 infection leads to the generation of cardiac myosin heavy chain-?-reactive CD4 T cells in A/J mice.
Coxsackievirus induced myocarditis in mice: cardiac myosin autoantibodies do not cross-react with the virus.
Cryptococcus neoformans virulence is enhanced after growth in the genetically malleable host Dictyostelium discoideum.
Discovery of the genes in response to white spot syndrome virus (WSSV) infection in Fenneropenaeus chinensis through cDNA microarray.
Effective adenovirus-mediated gene expression in adult murine skeletal muscle.
Enteropathogenic Escherichia coli-induced myosin light chain phosphorylation alters intestinal epithelial permeability.
EphrinA2 regulates clathrin mediated KSHV endocytosis in fibroblast cells by coordinating integrin-associated signaling and c-Cbl directed polyubiquitination.
Expression of a mutation causing hypertrophic cardiomyopathy disrupts sarcomere assembly in adult feline cardiac myocytes.
From infection to autoimmunity.
Functional role for the class IX myosin myr5 in epithelial cell infection by Shigella flexneri.
Genetic complexity of autoimmune myocarditis.
Hepatic Interferon-?3 (IFNL3) Gene Expression Reveals Not to Be Attenuated in Non-Favorable IFNL3 rs4803217 or IFNL4 rs368234815 Minor Allele Carriers in Chronic Hepatitis C.
High Transcriptional Activity and Diverse Functional Repertoires of Hundreds of Giant Viruses in a Coastal Marine System.
Host cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the F protein.
Immunization with Brugia malayi Myosin as Heterologous DNA Prime Protein Boost Induces Protective Immunity against B. malayi Infection in Mastomys coucha.
Immunization with the recombinant myosin regulatory light chain (FhrMRLC) in Adjuplex® adjuvant elicits a Th1-biased immune response and a reduction of parasite burden in Fasciola hepatica infected rats.
Impairing the function of MLCK, myosin Va or myosin Vb disrupts Rhinovirus B14 replication.
Improvement of the yields of recombinant actin and myosin V-HMM in the insect cell/baculovirus system by the addition of nutrients to the high-density cell culture.
In Vivo nonlinear optical imaging of immune responses: tissue injury and infection.
Induced paternal effects mimic cytoplasmic incompatibility in Drosophila.
Induction of antigen specific peripheral humoral tolerance to cardiac myosin does not prevent CB3-mediated autoimmune myocarditis.
Infection with Moloney murine sarcoma virus inhibits myogenesis and alters the myogenic-associated (2'-5')oligoadenylate synthetase expression and activity.
Inhibition by stabilization: targeting the Plasmodium falciparum aldolase-TRAP complex.
Inhibition of MLC phosphorylation restricts replication of influenza virus--a mechanism of action for anti-influenza agents.
Interaction of c-Cbl with myosin IIA regulates Bleb associated macropinocytosis of Kaposi's sarcoma-associated herpesvirus.
Intestinal epithelial cell protein phosphorylation in enteropathogenic Escherichia coli diarrhoea.
Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase-dependent fashion.
Loss of FGF receptor 1 signaling reduces skeletal muscle mass and disrupts myofiber organization in the developing limb.
Mapping Autoantibodies in Children With Acute Rheumatic Fever.
MicroRNA let-7f-5p Inhibits Porcine Reproductive and Respiratory Syndrome Virus by Targeting MYH9.
Moesin and myosin IIA modulate phagolysosomal biogenesis in macrophages.
Mouse cytomegalovirus infection induces antibodies which cross-react with virus and cardiac myosin: a model for the study of molecular mimicry in the pathogenesis of viral myocarditis.
MYH9 is an Essential Factor for Porcine Reproductive and Respiratory Syndrome Virus Infection.
Myocarditis: Infection Versus Autoimmunity.
Myosin autoimmunity is not essential for cardiac inflammation in acute Chagas' disease.
Myosin heavy chain is a dominant parasite antigen recognized by antibodies in sera from donors with filarial infections.
Myosin Va enhances secretion of herpes simplex virus 1 virions and cell surface expression of viral glycoproteins.
Myosins VIII and XI play distinct roles in reproduction and transport of tobacco mosaic virus.
Non-muscle myosin as target antigen for human autoantibodies in patients with hepatitis C virus-associated chronic liver diseases.
Non-muscle Myosin II: Role in Microbial Infection and Its Potential as a Therapeutic Target.
Nonmuscle myosin heavy chain IIA is a critical factor contributing to the efficiency of early infection of severe fever with thrombocytopenia syndrome virus.
Organization of cytoskeleton elements during herpes simplex virus type 1 infection of human fibroblasts: an immunofluorescence study.
Osteoprotegerin is sensitive to actomyosin tension in human periodontal ligament fibroblasts.
Overexpression of Six1 leads to retardation of myogenic differentiation in C2C12 myoblasts.
Parasites, proteomics and performance: effects of gregarine gut parasites on dragonfly flight muscle composition and function.
Phosphorylation is required for myosin regulatory light chain (PmMRLC) to control yellow head virus infection in shrimp hemocytes.
Phosphorylation of myosin light chain at distinct sites and its association with the cytoskeleton during enteropathogenic Escherichia coli infection.
Phosphorylation of Nonmuscle myosin II-A regulatory light chain resists Sendai virus fusion with host cells.
Polar localizing class V myosin chitin synthases are essential during early plant infection in the plant pathogenic fungus Ustilago maydis.
Polyomavirus genome and polyomavirus enhancer-driven gene expression during myogenesis.
Productive Entry of Foot-and-Mouth Disease Virus via Macropinocytosis Independent of Phosphatidylinositol 3-Kinase.
Proteases from Schistosoma mansoni cercariae cleave IgE at solvent exposed interdomain regions.
Rac1 and Cdc42 GTPases cross-talk regulates formation of filopodia required for Dengue virus type-2 entry into HMEC-1 cells.
Recent advances in the management of autoimmune myocarditis: insights from animal studies.
Rhinovirus C15 Induces Airway Hyperresponsiveness Via Calcium Mobilization in Airway Smooth Muscle.
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
Schistosoma japonicum myosin: cloning, expression and vaccination studies with the homologue of the S. mansoni myosin fragment IrV-5.
Soft-shelled turtle iridovirus enters cells via cholesterol-dependent, clathrin-mediated endocytosis as well as macropinocytosis.
Spontaneous autoimmune myocarditis and cardiomyopathy in HLA-DQ8.NODAbo transgenic mice.
Spontaneous myocarditis mimicking human disease occurs in the presence of an appropriate MHC and non-MHC background in transgenic mice.
Src-dependent Tyrosine Phosphorylation of Non-muscle Myosin Heavy Chain-IIA Restricts Listeria monocytogenes Cellular Infection.
The enteropathogenic E. coli effector EspB facilitates microvillus effacing and antiphagocytosis by inhibiting myosin function.
The molecular mechanism of induction of unfolded protein response by Chlamydia.
The Myosin5-mediated Actomyosin Motility System is Required for Verticillium Pathogenesis of Cotton.
The nonideal coiled coil of M protein and its multifarious functions in pathogenesis.
Toxoplasma gondii Impairs Myogenesis in vitro, With Changes in Myogenic Regulatory Factors, Altered Host Cell Proliferation and Secretory Profile.
Trichinella spp.: differential expression of acid phosphatase and myofibrillar proteins in infected muscle cells.
Trypanosoma cruzi disrupts myofibrillar organization and intracellular calcium levels in mouse neonatal cardiomyocytes.
Trypanosoma cruzi: predominance of IgG2a in nonspecific humoral response during experimental Chagas' disease.
Unconventional myosin VIIa and vezatin, two proteins crucial for Listeria entry into epithelial cells.
Vaccination with 73kDa recombinant heavy chain myosin generates high level of protection against Brugia malayi challenge in jird and mastomys models.
Verifying the stability of selected genes for normalization in Q PCR experiments of Spodoptera frugiperda cells during AcMNPV infection.
Viral myocarditis.
[Impact of chronic Chlamydia pneumoniae infection on left ventricular remodeling after myocardial infarction]
[Overexpression of Hath1 induces production of hair cell-like cells in greater epithelial ridge cell cultures from postnatal rat cochlea]
[Virus demonstration and pathologic changes in different phases of coxsackievirus B myocarditis in mice]
Inferior Wall Myocardial Infarction
Myocardial infarct size by serum troponin T and myosin light chain 1 concentration.
Infertility
Germ Granules Prevent Accumulation of Somatic Transcripts in the Adult Caenorhabditis elegans Germline.
Life without double-headed non-muscle myosin II motor proteins.
Syncytial germline architecture is actively maintained by contraction of an internal actomyosin corset.
Infertility, Male
Class VI unconventional myosin is required for spermatogenesis in Drosophila.
Mutations in non-muscle myosin 2A disrupt the actomyosin cytoskeleton in Sertoli cells and cause male infertility.
Inflammatory Bowel Diseases
A role for myosin IXb, a motor-RhoGAP chimera, in epithelial wound healing and tight junction regulation.
Aberrant expression of the polarity complex atypical PKC and non-muscle myosin IIA in active and inactive inflammatory bowel disease.
Association analysis of myosin IXB and type 1 diabetes.
Mice lacking myosin IXb, an inflammatory bowel disease susceptibility gene, have impaired intestinal barrier function and superficial ulceration in the ileum.
MYO9B gene polymorphisms are associated with the risk of inflammatory bowel diseases.
Myosin IXB gene region and gluten intolerance: linkage to coeliac disease and a putative dermatitis herpetiformis association.
Myosin Light Chain 9/12 Regulates the Pathogenesis of Inflammatory Bowel Disease.
The association of MYO9B gene in Italian patients with inflammatory bowel diseases.
Influenza, Human
Attempts at detection of actomyosin associated with influenza virus.
Elevated serum myosin light chain I in influenza patients.
Erratum for Elevated Serum Myosin Light Chain I in Influenza Patients.
Inhibition of MLC phosphorylation restricts replication of influenza virus--a mechanism of action for anti-influenza agents.
Role of the actin cytoskeleton during influenza virus internalization into polarized epithelial cells.
Specialized CC-chemokine secretion by Th1 cells in destructive autoimmune myocarditis.
The presence of both antivirus and antiself antibodies in sera from patients with adenovirus and influenza B.
Insulin Resistance
Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions.
Effect of training with different mechanical loadings on MyHC and GLUT4 changes.
Functional roles for myosin 1c in cellular signaling pathways.
Impaired insulin-mediated vasorelaxation in diabetic Goto-Kakizaki rats is caused by impaired Akt phosphorylation.
Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle.
Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men.
Transcriptomic Profiling of Skeletal Muscle Reveals Candidate Genes Influencing Muscle Growth and Associated Lipid Composition in Portuguese Local Pig Breeds.
Intellectual Disability
Identification of mRNA/protein (mRNP) complexes containing Puralpha, mStaufen, fragile X protein, and myosin Va and their association with rough endoplasmic reticulum equipped with a kinesin motor.
Myosin Va controls oligodendrocyte morphogenesis and myelination.
Myosin Va is required for the transport of fragile X mental retardation protein (FMRP) granules.
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Intervertebral Disc Degeneration
Adaptations to the Multifidus Muscle in Response to Experimentally Induced Intervertebral Disc Degeneration.
Intestinal Failure
Compound Heterozygous Myosin 5B (Myo5b) Mutation with Early Onset Progressive Cholestasis and No Intestinal Failure.
Intestinal Obstruction
[Myosin B ATPase activity of the intestinal smooth muscle in intestinal obstruction]
Intestinal Volvulus
Characterization of a muscle-associated antigen from Wuchereria bancrofti.
Comparison of the body wall myosin heavy chain sequences from Onchocerca volvulus and Brugia malayi.
Construction of Onchocerca volvulus cDNA libraries and partial characterization of the cDNA for a major antigen.
Immunological cross-reaction between an Onchocerca paramyosin-like molecule and a microfilaria surface antigen.
Structural characteristics of the Ascaris allergen, ABA-1.
Intracranial Arteriovenous Malformations
Expression of myosin heavy chain isoforms by smooth muscle cells in cerebral arteriovenous malformations.
Iron Overload
Iron overload exacerbates age-associated cardiac hypertrophy in a mouse model of hemochromatosis.
Mechanisms involved in the in vitro contractile dysfunction induced by different concentrations of ferrous iron in the rat myocardium.
Ischemic Contracture
[Experimental studies on a compartment syndrome caused by a tourniquet]
Ischemic Stroke
Direct myosin-2 inhibition enhances cerebral perfusion resulting in functional improvement after ischemic stroke.
Keloid
Admixture mapping identifies a locus at 15q21.2-22.3 associated with keloid formation in African Americans.
Angiotensin-II Mediates Non-Muscle Myosin II Activation and Expression and Contributes to Human Keloid Disease Progression.
Keloids and non-diabetic kidney disease: Similarities and the APOL1-MYH9 haplotype as a possible genetic link.
[Experimental study of actin and myosin in the scar tissue]
Kidney Diseases
APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin.
Background strain and the differential susceptibility of podocyte-specific deletion of Myh9 on murine models of experimental glomerulosclerosis and HIV nephropathy.
Essential hypertension and risk of nephropathy: a reappraisal.
Genetic basis of nondiabetic end-stage renal disease.
Identification of a putative network of actin-associated cytoskeletal proteins in glomerular podocytes defined by co-purified mRNAs.
MYH9 genetic variants associated with glomerular disease: what is the role for genetic testing?
Non-muscle myosin II deletion in the developing kidney causes ureter-bladder misconnection and apical extrusion of the nephric duct lineage epithelia.
Nonmuscle Myosin II Regulates the Morphogenesis of Metanephric Mesenchyme-Derived Immature Nephrons.
Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans.
The Spectrum of MYH9-Associated Nephropathy.
Kidney Failure, Chronic
Association of MYH9 rs3752462 and rs5756168 Polymorphisms With Transplanted Kidney Artery Stenosis.
Coincident idiopathic focal segmental glomerulosclerosis collapsing variant and diabetic nephropathy in an African American homozygous for MYH9 risk variants.
Effects of FSGS-associated mutations on the stability and function of myosin-1 in fission yeast.
Hypertension-associated kidney disease: perhaps no more.
KIDNEY DISEASE GENETICS AND THE IMPORTANCE OF DIVERSITY IN PRECISION MEDICINE.
MYH9 and APOL1 are both associated with sickle cell disease nephropathy.
MYH9 is associated with nondiabetic end-stage renal disease in African Americans.
Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD.
Pilot study of an association between a common variant in the non-muscle myosin heavy chain 9 (MYH9) gene and type 2 diabetic nephropathy in a Taiwanese population.
Polymorphisms in MYH9 are associated with diabetic nephropathy in European Americans.
Polymorphisms in the non-muscle myosin heavy chain 9 gene (MYH9) are strongly associated with end-stage renal disease historically attributed to hypertension in African Americans.
Polymorphisms in the non-muscle myosin heavy chain gene (MYH9) are associated with lower glomerular filtration rate in mixed ancestry diabetic subjects from South Africa.
Polymorphisms in the Nonmuscle Myosin Heavy Chain 9 Gene (MYH9) Are Associated with Albuminuria in Hypertensive African Americans: The HyperGEN Study.
Reduced synthesis of muscle proteins in chronic renal failure.
Sickle cell trait is not independently associated with susceptibility to end-stage renal disease in African Americans.
Leiomyoma
Abnormal expression of leiomyoma cytoskeletal proteins involved in cell migration.
alpha-1-Antitrypsin, alpha-1-antichymotrypsin, actin, and myosin in uterine sarcomas.
Differentiation, proliferation and apoptosis levels in human leiomyoma and leiomyosarcoma.
Endobronchial Smooth Muscle Tumors: A Series of Five Cases Highlighting Pitfalls in Diagnosis.
Establishment of a novel mouse xenograft model of human uterine leiomyoma.
Myosin heavy chain isoform expression in human myometrium: presence of an embryonic nonmuscle isoform in leiomyomas and in cultured cells.
Overexpression of myosin is associated with the development of uterine myoma.
Smooth and skeletal muscle myosins in spindle cell tumors of soft tissue. An immunohistochemical study.
Ulcerated gastric leiomyoma causing massive upper gastrointestinal bleeding: A case report.
Leiomyosarcoma
alpha-1-Antitrypsin, alpha-1-antichymotrypsin, actin, and myosin in uterine sarcomas.
Differentiation, proliferation and apoptosis levels in human leiomyoma and leiomyosarcoma.
Immunoreactivity of paraffin-embedded normal tissues and mesenchymal tumors for smooth muscle myosin.
Indium 111 antimyosin for the detection of leiomyosarcoma and rhabdomyosarcoma.
Metastasis of a myxoid leiomyosarcoma via the renal and hepatic portal circulation in a sarus crane (Grus antigone).
Myosin regulatory light chain phosphorylation is associated with leiomyosarcoma development.
Ni3S2-induced leiomyosarcomas in rabbit skeletal muscle: analysis of the tumoral myosin and its significance in the retrodifferentiation concept.
Pleomorphic and dedifferentiated leiomyosarcoma: clinicopathologic and immunohistochemical study of 41 cases.
Radio-immunodetection of myosarcoma using 111indium antimyosin.
Radioimmunodetection in rhabdo- and leiomyosarcoma with 111In-anti-myosin monoclonal antibody complex.
Smooth and skeletal muscle myosins in spindle cell tumors of soft tissue. An immunohistochemical study.
Leprosy
Autoimmunity to Tropomyosin-Specific Peptides Induced by Mycobacterium leprae in Leprosy Patients: Identification of Mimicking Proteins.
Leukemia
A gene for a myosin peptide is disrupted by the inv(16)(p13q22) in acute nonlymphocytic leukemia M4Eo.
A thirteen?gene set efficiently predicts the prognosis of glioblastoma.
Acceleration of G(1) cooperates with core binding factor beta-smooth muscle myosin heavy chain to induce acute leukemia in mice.
Antigen-induced secretion of histamine and the phosphorylation of myosin by protein kinase C in rat basophilic leukemia cells.
ATP gamma S induces actin and myosin rearrangement during histamine secretion in a rat basophilic leukemia cell line (RBL-2H3).
Enhancement of the phosphorylation of membrane bound myosin light chain by antigen stimulation in rat basophilic leukemia cells.
Expression of a mutant myosin light chain that cannot be phosphorylated increases paracellular permeability.
Frontline Science: Tumor necrosis factor-? stimulation and priming of human neutrophil granule exocytosis.
In situ phosphorylation of human platelet and rat basophilic leukemia cell (RBL-2H3) myosin heavy chain and light chain.
Inversion and deletion of 16q22 defined by array CGH, FISH, and RT-PCR in a patient with AML.
Isolation and characterization of actin and myosin from B-lymphocytic guinea pig leukemia cells.
Leukemogenic potency of the novel FLT3-N676K mutant.
Localization of the gene responsible for the op (osteopetrotic) defect in rats on chromosome 10.
Molecular cloning and sequencing of myosin light chains in human megakaryoblastic leukemia cells.
Myosin-IIA regulates leukemia engraftment and brain infiltration in a mouse model of acute lymphoblastic leukemia.
RT-PCR diagnosis of patients with acute nonlymphocytic leukemia and inv(16)(p13q22) and identification of new alternative splicing in CBFB-MYH11 transcripts.
Smooth muscle type isoform of 20 kDa myosin light chain is expressed in monocyte/macrophage cell lineage.
The inv(16) in acute nonlymphocytic leukemia: a turnabout for myosin heavy chain.
The MYO1F, unconventional myosin type 1F, gene is fused to MLL in infant acute monocytic leukemia with a complex translocation involving chromosomes 7, 11, 19 and 22.
Two distinct mechanisms for redistribution of lymphocyte surface macromolecules. I. Relationship to cytoplasmic myosin.
Leukemia, B-Cell
Isolation and characterization of actin and myosin from B-lymphocytic guinea pig leukemia cells.
Phosphorylation of lymphocyte myosin catalyzed in vitro and in intact cells.
Leukemia, Lymphocytic, Chronic, B-Cell
Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA.
Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed non-muscle myosin heavy chain IIA: implications for patient outcome and cell of origin.
Purification and characterization of actin from normal and chronic lymphocytic leukemia lymphocytes.
Leukemia, Lymphoid
Genome-wide association meta-analysis of circulating odd-numbered chain saturated fatty acids: Results from the CHARGE Consortium.
The selective role of myosin VI in lymphoid leukemia cell migration.
Leukemia, Monocytic, Acute
The MYO1F, unconventional myosin type 1F, gene is fused to MLL in infant acute monocytic leukemia with a complex translocation involving chromosomes 7, 11, 19 and 22.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Interactions of actin, myosin, and an actin-binding protein of chronic myelogenous leukemia leukocytes.
Leukemia, Myeloid
A cofactor protein required for actin activation of myosin Mg2+ATPase activity in leukemic myeloblasts.
Changes in myosin during differentiation of myeloid leukemia cells.
Differentiation of myeloid leukemia cells and changes in their contractile proteins.
Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability.
Multimerization via its myosin domain facilitates nuclear localization and inhibition of core binding factor (CBF) activities by the CBFbeta-smooth muscle myosin heavy chain myeloid leukemia oncoprotein.
Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice.
Leukemia, Myeloid, Acute
A gene for a myosin peptide is disrupted by the inv(16)(p13q22) in acute nonlymphocytic leukemia M4Eo.
Acute myeloid leukemia with Inv (16) produces a chimeric transcription factor with a myosin heavy chain tail.
Composite Small Lymphocytic Lymphoma and Extra-medullary Myeloid Tumor: A Potential Diagnostic Pitfall.
Core binding factor beta-smooth muscle myosin heavy chain chimeric protein involved in acute myeloid leukemia forms unusual nuclear rod-like structures in transformed NIH 3T3 cells.
Core-binding factor beta (CBFbeta), but not CBFbeta-smooth muscle myosin heavy chain, rescues definitive hematopoiesis in CBFbeta-deficient embryonic stem cells.
Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia.
Identification of a region on the outer surface of the CBFbeta-SMMHC myeloid oncoprotein assembly competence domain critical for multimerization.
Identification of the chimeric protein product of the CBFB-MYH11 fusion gene in inv(16) leukemia cells.
Mechanisms of transcriptional repression by the t(8;21)-, t(12;21)-, and inv(16)-encoded fusion proteins.
Molecular insights into PEBP2/CBF beta-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBF beta.
Overexpression of core-binding factor alpha (CBF alpha) reverses cellular transformation by the CBF beta-smooth muscle myosin heavy chain chimeric oncoprotein.
RNA sequencing reveals a unique fusion of the lysine (K)-specific methyltransferase 2A and smooth muscle myosin heavy chain 11 in myelodysplastic syndrome and acute myeloid leukemia.
RT-PCR diagnosis of patients with acute nonlymphocytic leukemia and inv(16)(p13q22) and identification of new alternative splicing in CBFB-MYH11 transcripts.
Structure of the leukemia-associated human CBFB gene.
Targeting Actomyosin Contractility Suppresses Malignant Phenotypes of Acute Myeloid Leukemia Cells.
The inv(16) cooperates with ARF haploinsufficiency to induce acute myeloid leukemia.
The inv(16) in acute nonlymphocytic leukemia: a turnabout for myosin heavy chain.
The leukemic core binding factor beta-smooth muscle myosin heavy chain (CBF beta-SMMHC) chimeric protein requires both CBF beta and myosin heavy chain domains for transformation of NIH 3T3 cells.
Leukemia, Myelomonocytic, Acute
Inversion and deletion of 16q22 defined by array CGH, FISH, and RT-PCR in a patient with AML.
Leukemia, T-Cell
Oncogenic potential of the miR-106-363 cluster and its implication in human T-cell leukemia.
lipoprotein lipase deficiency
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Liver Abscess
Roles of cell adhesion and cytoskeleton activity in Entamoeba histolytica pathogenesis: a delicate balance.
Liver Cirrhosis
Blebbistatin inhibits contraction and accelerates migration in mouse hepatic stellate cells.
Liver Cirrhosis, Biliary
Anti-smooth muscle antibodies (ASMAs) and anti-cytoskeleton antibodies (ACTAs) in liver diseases: a comparison of classical indirect immunofluorescence with ELISA.
Sera with high levels of anti-smooth muscle and anti-mitochondrial antibodies frequently bind to cytoskeleton proteins.
Liver Diseases
Anti-smooth muscle antibodies (ASMAs) and anti-cytoskeleton antibodies (ACTAs) in liver diseases: a comparison of classical indirect immunofluorescence with ELISA.
Autoantibodies and circulating immune complexes in sera from patients with hepatitis B virus-related chronic liver disease.
Non-muscle myosin as target antigen for human autoantibodies in patients with hepatitis C virus-associated chronic liver diseases.
Working capacity and expression of myosin heavy chain isoforms in skeletal muscle of chronic alcoholic men without liver disease after 1 day and 4 weeks of alcohol abstinence.
Liver Neoplasms
LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex.
Long QT Syndrome
[Molecular genetics of cardiovascular diseases]
Lung Injury
A self-organized actomyosin drives multiple intercellular junction disruption and directly promotes neutrophil recruitment in lipopolysaccharide-induced acute lung injury.
A transgenic mouse with vascular endothelial over-expression of the non-muscle myosin light chain kinase-2 isoform is susceptible to inflammatory lung injury: role of sexual dimorphism and age.
Differential modulation of claudin 4 expression and myosin light chain phosphorylation by thyroid function in lung injury.
Interaction of surfactant protein A with cellular myosin.
Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins.
Peroxisome proliferators alter lipid acquisition and elastin gene expression in neonatal rat lung fibroblasts.
Lung Neoplasms
4-Hydroxyhexenal and 4-hydroxynonenal are mediators of the anti-cachectic effect of n-3 and n-6 polyunsaturated fatty acids on human lung cancer cells.
Bovine Genome-wide Association Study for Genetic Elements to Resist the Infection of Foot-and-mouth Disease in the Field.
Genetic alterations responsible for metastatic phenotypes of lung cancer cells.
Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer.
Irradiation-tolerant lung cancer cells acquire invasive ability dependent on dephosphorylation of the myosin regulatory light chain.
KIF13A-regulated RhoB plasma membrane localization governs membrane blebbing and blebby amoeboid cell migration.
Lentivirus-Mediated Silencing of Myosin VI Inhibits Proliferation and Cell Cycle Progression in Human Lung Cancer Cells.
MYO18B, a candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer.
Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression.
Quantitative proteomic analysis identifies CPNE3 as a novel metastasis-promoting gene in NSCLC.
Receptor-interacting Ser/Thr kinase 1 (RIPK1) and myosin IIA-dependent ceramidosomes form membrane pores that mediate blebbing and necroptosis.
Restored expression of the MYO18B gene suppresses orthotopic growth and the production of bloody pleural effusion by human malignant pleural mesothelioma cells in SCID mice.
Substrate stiffness regulates filopodial activities in lung cancer cells.
TGF-?1 Causes EMT by regulating N-Acetyl Glucosaminyl Transferases via Downregulation of Non Muscle Myosin II-A through JNK/P38/PI3K pathway in lung cancer.
Lupus Erythematosus, Systemic
Myosin IXB gene region and gluten intolerance: linkage to coeliac disease and a putative dermatitis herpetiformis association.
Natural autoantibodies in systemic lupus erythematosus.
Lupus Nephritis
The non-muscle Myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans.
Lymphadenopathy
Autoimmune syndrome after induction of neonatal tolerance to alloantigens: analysis of the role of donor T cells in the induction of autoimmunity.
Lymphatic Metastasis
Aberrant Myosin 1b Expression Promotes Cell Migration and Lymph Node Metastasis of HNSCC.
Myosin 5a regulates tumor migration and epithelial-mesenchymal transition in esophageal squamous cell carcinoma: utility as a prognostic factor.
The Bidirectional Regulation between MYL5 and HIF-1? Promotes Cervical Carcinoma Metastasis.
Lymphoma
CDCA7 finely tunes cytoskeleton dynamics to promote lymphoma migration and invasion.
Immunohistochemical localization of smooth muscle myosin in human spleen, lymph node, and other lymphoid tissues. Unique staining patterns in splenic white pulp and sinuses, lymphoid follicles, and certain vasculature, with ultrastructural correlations.
Immunohistochemical study of alveolar and embryonal rhabdomyosarcoma.
Interactions between a lymphoma membrane-associated guanosine 5'-triphosphate-binding protein and the cytoskeleton during receptor patching and capping.
Life without double-headed non-muscle myosin II motor proteins.
Localization of cytoplasmic and skeletal myosins in developing muscle cells by double-label immunofluorescence.
miR-155 regulates HGAL expression and increases lymphoma cell motility.
Morin attenuates dexamethasone-mediated oxidative stress and atrophy in mouse C2C12 skeletal myotubes.
Non-muscle myosin heavy chain (MYH9): a new partner fused to ALK in anaplastic large cell lymphoma.
Paradoxical effect of testosterone supplementation therapy on cardiac ischemia/reperfusion injury in aged rats.
Regulation of receptor capping in mouse lymphoma T cells by Ca2+-activated myosin light chain kinase.
The characteristics of antibodies of mice immunized by human unconventional myosin 1c.
Lymphoma, B-Cell
miR-155 regulates HGAL expression and increases lymphoma cell motility.
Paradoxical effect of testosterone supplementation therapy on cardiac ischemia/reperfusion injury in aged rats.
Lymphoma, Large B-Cell, Diffuse
miR-155 regulates HGAL expression and increases lymphoma cell motility.
Lymphoma, Large-Cell, Anaplastic
Non-muscle myosin heavy chain (MYH9): a new partner fused to ALK in anaplastic large cell lymphoma.
Lymphoma, Non-Hodgkin
Synthetic peptides derived from the nonmuscle myosin light chains are highly specific substrates for protein kinase C.
Macular Degeneration
Deletion of myosin VI causes slow retinal optic neuropathy and age-related macular degeneration (AMD)-relevant retinal phenotype.
Malaria
A GFP-Actin reporter line to explore microfilament dynamics across the malaria parasite lifecycle.
A malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasion.
Actomyosin forces and the energetics of red blood cell invasion by the malaria parasite Plasmodium falciparum.
Actomyosin motor in the merozoite of the malaria parasite, Plasmodium falciparum: implications for red cell invasion.
Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite.
Automated classification of Plasmodium sporozoite movement patterns reveals a shift towards productive motility during salivary gland infection.
Calcium-dependent phosphorylation alters class XIVa myosin function in the protozoan parasite Toxoplasma gondii.
Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility.
Contractile protein system in the asexual stages of the malaria parasite Plasmodium falciparum.
Coupling of Retrograde Flow to Force Production During Malaria Parasite Migration.
Crystal structures of stapled and hydrogen bond surrogate peptides targeting a fully buried protein-helix interaction.
Full-length Plasmodium falciparum myosin A and essential light chain PfELC structures provide new anti-malarial targets.
Interaction and dynamics of the Plasmodium falciparum MTIP-MyoA complex, a key component of the invasion motor in the malaria parasite.
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Plasmodium falciparum coronin organizes arrays of parallel actin filaments potentially guiding directional motility in invasive malaria parasites.
Protein multi-scale organization through graph partitioning and robustness analysis: application to the myosin-myosin light chain interaction.
Quantitative analysis of Plasmodium ookinete motion in three dimensions suggests a critical role for cell shape in the biomechanics of malaria parasite gliding motility.
Regulation of apicomplexan microfilament dynamics by a minimal set of actin-binding proteins.
Targeting a dynamic protein-protein interaction: fragment screening against the malaria myosin A motor complex.
The Binding of Plasmodium falciparum Adhesins and Erythrocyte Invasion Proteins to Aldolase Is Enhanced by Phosphorylation.
The closed MTIP-myosin A-tail complex from the malaria parasite invasion machinery.
The compact conformation of the Plasmodium knowlesi myosin tail interacting protein MTIP in complex with the C-terminal helix of myosin A.
The MTIP-myosin A complex in blood stage malaria parasites.
The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain.
[Method for rapid synchronization of different growth cycles of Plasmodium falciparum in vitro and application in differential gene expression profile of 3D7 after dihydroartemisinin treatment].
Malnutrition
Differential effects of carbohydrate intake on cardiac myosin isoform expression in normal weanling and adult rats.
Effect of exercise during rehabilitation on swimming performance, metabolism and function of muscle in rats.
Effects of perinatal undernutrition on elimination of immature myosin isoforms in the rat diaphragm.
Growth hormone restores aged diaphragm myosin composition and performance after chronic undernutrition.
Nutrition-hormone receptor-gene interactions: implications for development and disease.
Postnatal regulation of myosin heavy chain isoform expression and metabolic enzyme activity by nutrition.
Refeeding reverses cardiac myosin shifts induced by undernutrition in aged rats: modulation by growth hormone.
Malocclusion
Change of mRNA amount of myosin heavy chain in masseter muscle after orthognathic surgery of patients with malocclusion.
Myosin heavy chain protein and gene expression in the masseter muscle of adult patients with distal or mesial malocclusion.
Mastitis
Natural antibodies related to metabolic and mammary health in dairy cows.
Megacolon
Hypertrophy of colonic smooth muscle: contractile proteins, shortening velocity, and regulation.
Hypertrophy of colonic smooth muscle: structural remodeling, chemical composition, and force output.
Novel smooth muscle markers reveal abnormalities of the intestinal musculature in severe colorectal motility disorders.
Melanoma
Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation.
An autophagic deficit in the uterine vessel microenvironment provokes hyperpermeability through deregulated VEGFA, NOS1, and CTNNB1.
Effect of Ninjin'yoeito on the Loss of Skeletal Muscle Function in Cancer-Bearing Mice.
Expression of cytoskeletal components in melanocytic skin lesions. An immunohistochemical study.
Extinction of muscle-specific properties in somatic cell heterokaryons.
Inhibition of dendrite formation in mouse melanocytes transiently transfected with antisense DNA to myosin Va.
Interdependency of cell adhesion, force generation and extracellular proteolysis in matrix remodeling.
KIF13A-regulated RhoB plasma membrane localization governs membrane blebbing and blebby amoeboid cell migration.
Knockdown of myosin VI by lentivirus-mediated short hairpin RNA suppresses proliferation of melanoma.
Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance.
Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis.
Nonmuscle myosin IIA and IIB have distinct functions in the exocytosis-dependent process of cell membrane repair.
P-cadherin counteracts myosin II-B function: implications in melanoma progression.
PKC mediates 12(S)-HETE-induced cytoskeletal rearrangement in B16a melanoma cells.
Procyanidin C1 Inhibits Melanoma Cell Growth by Activating 67-kDa Laminin Receptor Signaling.
Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination.
ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma.
Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin.
Suppression of antifolate resistance by targeting the myosin Va trafficking pathway in melanoma.
TGF-?-Induced Transcription Sustains Amoeboid Melanoma Migration and Dissemination.
The purification and quantitation of myosin from cultured cells.
Unconventional myosin VIIA promotes melanoma progression.
WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion.
Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors.
Melanoma, Experimental
Segregation and activation of myosin IIB creates a rear in migrating cells.
Mesothelioma
h-Caldesmon, a useful positive marker in the diagnosis of pleural malignant mesothelioma, epithelioid type.
Microcephaly
A multidimensional proteomic approach to identify hypertrophy-associated proteins.
The microcephaly protein Asp regulates neuroepithelium morphogenesis by controlling the spatial distribution of myosin II.
Microphthalmos
Clear cell myomelanocytic tumor of the falciform ligament/ligamentum teres: a novel member of the perivascular epithelioid clear cell family of tumors with a predilection for children and young adults.
Migraine Disorders
Network Pharmacology Analysis of the Effects of Achyranthis Bidentatae Radix Plus Semen Vaccariae on Migraine-Induced Erectile Dysfunction.
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Mitral Valve Insufficiency
Acute changes in myosin heavy chain synthesis rate in pressure versus volume overload.
Maximal actomyosin ATPase activity and in vitro myosin motility are unaltered in human mitral regurgitation heart failure.
Mechanisms of cardiac hypertrophy in canine volume overload.
Myocardial force-frequency defect in mitral regurgitation heart failure is reversed by forskolin.
Myosin types in the human heart. An immunofluorescence study of normal and hypertrophied atrial and ventricular myocardium.
[Peculiar mitral periannular cardiac muscle lesion in rabbits with experimentally-induced mitral regurgitation by vagus stimulation: investigation of a collagen increase and a myosin heavy chain isozyme change]
Mitral Valve Stenosis
Myosin types in the human heart. An immunofluorescence study of normal and hypertrophied atrial and ventricular myocardium.
Motor Neuron Disease
Intricate effects of primary motor neuronopathy on contractile proteins and metabolic muscle enzymes as revealed by label-free mass spectrometry.
Mouth Neoplasms
Long noncoding RNA HAR1A regulates oral cancer progression through the alpha-kinase 1, bromodomain 7, and myosin IIA axis.
Quantitative proteomics reveals myosin and actin as promising saliva biomarkers for distinguishing pre-malignant and malignant oral lesions.
Movement Disorders
Role of Myosin Va in the plasticity of the vertebrate neuromuscular junction in vivo.
Mucocutaneous Lymph Node Syndrome
Anti-human cardiac myosin autoantibodies in Kawasaki syndrome.
Mucositis
Patchouli alcohol attenuates 5-fluorouracil-induced intestinal mucositis via TLR2/MyD88/NF-kB pathway and regulation of microbiota.
Multiple Sclerosis
Comparative study of natural autoantibodies in the serum and cerebrospinal fluid of normal individuals and patients with multiple sclerosis and other neurological diseases.
Isolation and identification in human blood serum of the proteins possessing the ability to bind with 48 kDa form of unconventional myosin 1c and their possible diagnostic and prognostic value.
Luminex-Coupled EliFACS: A Multiparametric Method to Enumerate and Functionally Characterize Antigen-Specific T cells in Human Peripheral Blood.
Muscle fiber type-specific myofibrillar actomyosin Ca2+ ATPase activity in multiple sclerosis.
The characteristics of antibodies of mice immunized by human unconventional myosin 1c.
Muscle Hypotonia
Congenital hypotonia due to myosin degeneration.
Myosin degeneration in a congenital myopathy.
Muscle Rigidity
CaATP prolongs strong actomyosin binding and promotes futile myosin stroke.
Muscle Spasticity
Alterations in protein kinase C activity and membrane lipid metabolism in cerebral vasospasm after subarachnoid hemorrhage.
Cellular and molecular mechanisms of coronary artery spasm: lessons from animal models.
Decreased capillarization and a shift to fast myosin heavy chain IIx in the biceps brachii muscle from young adults with spastic paresis.
Immunoblotting of contractile and cytoskeletal proteins of canine basilar artery in vasospasm.
Intraradial administration of fasudil inhibits augmented Rho kinase activity to effectively dilate the spastic radial artery during coronary artery bypass grafting surgery.
Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm.
Spastic tail muscles recover from myofiber atrophy and myosin heavy chain transformations in chronic spinal rats.
[Upregulated Rho-kinase and increased phosphorylation of myosin-binding subunit of myosin phosphates are key players in a porcine coronary artery spasm model with interleukin-1beta]
Muscle Weakness
Acute quadriplegic myopathy: an acquired "myosinopathy".
Differential expression of myosin heavy chain isoforms in the masticatory muscles of dystrophin-deficient mice.
Disrupted myosin cross-bridge cycling kinetics triggers muscle weakness in nebulin-related myopathy.
Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres.
Effects of a R133W beta-tropomyosin mutation on regulation of muscle contraction in single human muscle fibres.
Effects of hindlimb unweighting and aging on rat semimembranosus muscle and myosin.
Electrical Stimulation Prevents Preferential Skeletal Muscle Myosin Loss in Steroid-Denervation Rats.
Expression of the inclusion body myopathy 3 mutation in Drosophila depresses myosin function and stability and recapitulates muscle inclusions and weakness.
Functional effects of nemaline myopathy mutations on human skeletal alpha-actin.
Hereditary myosin myopathies.
Impaired Ca(2+) release contributes to muscle weakness in a rat model of critical illness myopathy.
Loss of muscle strength during sepsis is in part regulated by glucocorticoids and is associated with reduced muscle fiber stiffness.
Mechanical Signaling in the Pathophysiology of Critical Illness Myopathy.
Mechanisms underlying skeletal muscle weakness in human heart failure: alterations in single fiber myosin protein content and function.
Molecular Mechanisms of Muscle Weakness Associated with E173A Mutation in Tpm3.12. Troponin Ca2+ Sensitivity Inhibitor W7 Can Reduce the Damaging Effect of This Mutation.
Molecular Mechanisms of the Deregulation of Muscle Contraction Induced by the R90P Mutation in Tpm3.12 and the Weakening of This Effect by BDM and W7.
Molecular, cellular, and muscle strip mechanics of the mdx mouse diaphragm.
Muscle cell and motor protein function in patients with a IIa myosin missense mutation (Glu-706 to Lys).
Mutations in MYLPF Cause a Novel Segmental Amyoplasia that Manifests as Distal Arthrogryposis.
Myosinopathies: pathology and mechanisms.
Nemaline myopathy-related skeletal muscle ?-actin (ACTA1) mutation, Asp286Gly, prevents proper strong myosin binding and triggers muscle weakness.
New cardiac and skeletal protein aggregate myopathy associated with combined MuRF1 and MuRF3 mutations.
Non-weight bearing-induced muscle weakness: the role of myosin quantity and quality in MHC type II fibers.
Oxidative stress of myosin contributes to skeletal muscle dysfunction in rats with chronic heart failure.
The effect of age on protein metabolism.
The molecular mechanisms of a high Ca2+-sensitivity and muscle weakness associated with the Ala155Thr substitution in Tpm3.12.
[Hypothyroid hypertrophic myopathy following mantle irradiation for Hodgkin's disease. A case]
Muscular Atrophy
1,25-Dihydroxyvitamin D3 Inhibits Lipopolysaccharide-Induced Interleukin-6 Production by C2C12 Myotubes.
A Chalcone from Ashitaba (Angelica keiskei) Stimulates Myoblast Differentiation and Inhibits Dexamethasone-Induced Muscle Atrophy.
A computational model of skeletal muscle metabolism linking cellular adaptations induced by altered loading states to metabolic responses during exercise.
Activin A induces skeletal muscle catabolism via p38? mitogen-activated protein kinase.
Activity influences on soleus muscle myosin during rodent hindlimb suspension.
Acute effects of high-dose methylprednisolone on diaphragm muscle function.
Altered expression of skeletal muscle myosin isoforms in cancer cachexia.
AMP-Activated Protein Kinase as a Key Trigger for the Disuse-Induced Skeletal Muscle Remodeling.
Angiotensin-(1-7) decreases skeletal muscle atrophy induced by angiotensin II through a Mas receptor-dependent mechanism.
Antimuscle atrophy effect of nicotine targets muscle satellite cells partly through an ?7 nicotinic receptor in a murine hindlimb ischemia model.
Apoptosis and changes in contractile protein pattern in the skeletal muscle in heart failure.
Apoptosis in the skeletal muscle of patients with heart failure: investigation of clinical and biochemical changes.
Aspirin alleviates denervation-induced muscle atrophy via regulating the Sirt1/PGC-1? axis and STAT3 signaling.
Atrophy of the tongue following complete versus partial hypoglossal nerve transection in a canine model.
Beneficial effects on skeletal muscle of the angiotensin II type 1 receptor blocker irbesartan in experimental heart failure.
Cancer Cachexia Induces Preferential Skeletal Muscle Myosin Loss When Combined With Denervation.
Changes in PKB/Akt and calcineurin signaling during recovery in atrophied soleus muscle induced by unloading.
Changes in the flow birefringence of myosin as a result of muscular atrophy.
Cholic acid and deoxycholic acid induce skeletal muscle atrophy through a mechanism dependent on TGR5 receptor.
Comparative effects of neurally adjusted ventilatory assist and variable pressure support on lung and diaphragmatic function in a model of acute respiratory distress syndrome: A randomised animal study.
DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy.
Denervation Dynamically Regulates Integrin alpha7 Signaling Pathways and Microscopic Structures in Rats.
Differential regulation of myofibrillar proteins in skeletal muscles of septic mice.
Evidence of MyomiR network regulation of {beta}-myosin heavy chain gene expression during skeletal muscle atrophy.
Expression of developmentally regulated cytoskeleton and cell surface proteins in childhood spinal muscular atrophies.
Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo.
Fermented Feed Modulates Meat Quality and Promotes the Growth of Longissimus Thoracis of Late-Finishing Pigs.
Glucocorticoid-induced muscle atrophy: mechanisms and therapeutic strategies.
Glutamine prevents downregulation of myosin heavy chain synthesis and muscle atrophy from glucocorticoids.
Heart failure-induced skeletal myopathy in spontaneously hypertensive rats.
Identification of Withania somnifera-Silybum marianum-Trigonella foenum-graecum Formulation as a Nutritional Supplement to Contrast Muscle Atrophy and Sarcopenia.
Importance of immunohistochemical evaluation of developmentally regulated myosin heavy chains in human muscle biopsies.
Intermittent reloading does not prevent reduction in iron availability and hepcidin upregulation caused by hindlimb unloading.
Isobavachalcone attenuates myotube atrophy induced by TNF-? through muscle atrophy F-box signaling and the nuclear factor erythroid 2-related factor 2 cascade.
Isoquercitrin Delays Denervated Soleus Muscle Atrophy by Inhibiting Oxidative Stress and Inflammation.
Lactate Overload Inhibits Myogenic Activity in C2C12 Myotubes.
Mechanistic Role of Reactive Oxygen Species and Therapeutic Potential of Antioxidants in Denervation- or Fasting-Induced Skeletal Muscle Atrophy.
Mechano signaling pathways in an experimental intensive critical illness myopathy model.
Molecular and cellular defects of skeletal muscle in an animal model of acute quadriplegic myopathy.
Morin attenuates dexamethasone-mediated oxidative stress and atrophy in mouse C2C12 skeletal myotubes.
Muscle atrophy and preferential loss of myosin in prolonged critically ill patients.
Muscle Changes During Atrophy.
Muscle unloading induces slow to fast transitions in myofibrillar but not mitochondrial properties. Relevance to skeletal muscle abnormalities in heart failure.
Myosin heavy chain turnover and glucocorticoid deterrence by exercise in muscle.
Myricanol rescues dexamethasone-induced muscle dysfunction via a sirtuin 1-dependent mechanism.
N-Acetyl Cysteine attenuates the sarcopenia and muscle apoptosis induced by chronic liver disease.
Pancreatic cancer induces muscle wasting by promoting the release of pancreatic adenocarcinoma upregulated factor.
Plasma from septic shock patients induces loss of muscle protein.
Positive end-expiratory airway pressure does not aggravate ventilator-induced diaphragmatic dysfunction in rabbits.
Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: Underlying mechanisms.
Protective Effects of Clenbuterol against Dexamethasone-Induced Masseter Muscle Atrophy and Myosin Heavy Chain Transition.
Signaling pathways perturbing muscle mass.
Skeletal muscle adaptations to physical inactivity and subsequent retraining in young men.
Skeletal muscle myosin heavy chain expression in rats with monocrotaline-induced cardiac hypertrophy and failure. Relation to blood flow and degree of muscle atrophy.
Skeletal muscle wastage in Crohn's disease: a pathway shared with heart failure?
TGF-? requires the activation of canonical and non-canonical signalling pathways to induce skeletal muscle atrophy.
The mechanical behavior of activated skeletal muscle during stretch: effects of muscle unloading and MyHC isoform shifts.
The preventive effect of ?-carotene on denervation-induced soleus muscle atrophy in mice.
The role of calpains in ventilator-induced diaphragm atrophy.
Thermal preconditioning prevents fiber type transformation of the unloading induced-atrophied muscle in rats.
TNF Receptor-Associated Factor 6 Mediates TNF?-Induced Skeletal Muscle Atrophy in Mice During Aging.
Transgenic overexpression of locally acting insulin-like growth factor-1 inhibits ubiquitin-mediated muscle atrophy in chronic left-ventricular dysfunction.
Upregulation of the CaV 1.1-ryanodine receptor complex in a rat model of critical illness myopathy.
Using Whole Genome Sequencing in an African Subphenotype of Myasthenia Gravis to Generate a Pathogenetic Hypothesis.
[Basic results of an experiment with mammals on the Kosmos-782 biosatellite]
[Change of myosin heavy chain isoform expression and histocytochemical findings in skeletal muscular atrophy due to simulated weightlessness by hindlimb tenotomy]
[Effects of Ligustrazine and Radix Astragali on activities of myosin adenosine triphosphatase of soleus muscle and muscle atrophy in tail-suspended rats]
[Incorporation of radionitrogen-labeled glycine into myosin; role of muscle atrophy and topography.]
[Metabolism of skeletal muscle proteins in experimental hypokinesia in rats]
[The preventive effects of one herbal compound on activities of myosin adenosine triphosphatase of muscle fibers and muscle atrophy in tail-suspended rat].
Muscular Atrophy, Spinal
Myosin heavy chain composition of muscle fibers in spinal muscular atrophy.
Muscular Diseases
A Caenorhabditis elegans model of the myosin heavy chain IIa E706K [corrected] mutation.
A de novo mutation of the MYH7 gene in a large Chinese family with autosomal dominant myopathy.
A Drosophila model of dominant inclusion body myopathy 3 shows diminished myosin kinetics that reduce muscle power and yield myofibrillar defects.
A new de novo missense mutation in MYH2 expands clinical and genetic findings in hereditary myosin myopathies.
A novel missense mutation in the MYH7 gene causes an uncharacteristic phenotype of myosin storage myopathy: a case report.
A novel mutation expands the genetic and clinical spectrum of MYH7-related myopathies.
A novel MYH2 mutation in family members presenting with congenital myopathy, ophthalmoplegia and facial weakness.
A novel MYH7 mutation links congenital fiber type disproportion and myosin storage myopathy.
A novel MYH7 mutation occurring independently in French and Norwegian Laing distal myopathy families and de novo in one Finnish patient.
A Zebrafish Model for a Human Myopathy Associated with Mutation of the Unconventional Myosin MYO18B.
A1603P and K1617del, Mutations in ?-Cardiac Myosin Heavy Chain that Cause Laing Early-Onset Distal Myopathy, Affect Secondary Structure and Filament Formation In Vitro and In Vivo.
Aberrant movement of ?-tropomyosin associated with congenital myopathy causes defective response of myosin heads and actin during the ATPase cycle.
Actin-Myosin Interaction: Structure, Function and Drug Discovery.
Actinopathies and myosinopathies.
Acute myopathy after liver transplantation.
Acute myopathy with selective degeneration of myosin filaments following status asthmaticus treated with methylprednisolone and vecuronium.
Acute myopathy with selective lysis of myosin filaments.
Acute necrotizing myopathy of intensive care: electrophysiological studies.
Acute quadriplegia and loss of muscle myosin in patients treated with nondepolarizing neuromuscular blocking agents and corticosteroids: mechanisms at the cellular and molecular levels.
Acute quadriplegic myopathy unrelated to steroids or paralyzing agents: quantitative EMG studies.
Acute quadriplegic myopathy: analysis of myosin isoforms and evidence for calpain-mediated proteolysis.
Adenosine diphosphate effect on contractility of human muscle actomyosin: inhibition by ethanol and acetaldehyde.
Altered expression of ARPP protein in skeletal muscles of patients with muscular dystrophy, congenital myopathy and spinal muscular atrophy.
Amplitude of the actomyosin power stroke depends strongly on the isoform of the myosin essential light chain.
Apoptosis in the skeletal muscle of rats with heart failure is associated with increased serum levels of TNF-alpha and sphingosine.
Apoptosis of skeletal muscle myofibers and interstitial cells in experimental heart failure.
Arsenic inhibits myogenic differentiation and muscle regeneration.
Association of 25 bp deletion in MYBPC3 gene with left ventricle dysfunction in coronary artery disease patients.
ATOH8: a novel marker in human muscle fiber regeneration.
Autosomal dominant hyaline body myopathy: clinical variability and pathologic findings.
Autosomal dominant myopathy: missense mutation (Glu-706 --> Lys) in the myosin heavy chain IIa gene.
Bi-allelic mutations in uncoordinated mutant number-45 myosin chaperone B are a cause for congenital myopathy.
Biochemical and immunologic studies in a case of congenital myopathy with unusual morphologic features.
Cardiac and skeletal myopathy in beta myosin heavy-chain simian virus 40 tsA58 transgenic mice.
Cautionary note on the use of Caenorhabditis elegans to study muscle phenotypes caused by mutations in the human MYH7 gene.
Change in concentrations of myogenic components of serum during 93 h of strenuous physical exercise.
Clinical approach to the weak patient in the intensive care unit.
Congenital myopathies.
Congenital myopathies: an update.
Congenital myopathy due to myosin heavy chain 2 mutation presenting as chronic aspiration pneumonia in infancy.
Critical illness myopathy in a cervical spine-injured patient.
Critical illness myopathy unrelated to corticosteroids or neuromuscular blocking agents.
Critical illness myopathy: sepsis-mediated failure of the peripheral nervous system.
Deletion of the myopathy loop of Dictyostelium myosin II and its impact on motor functions.
Digenic mutational inheritance of the integrin alpha 7 and the myosin heavy chain 7B genes causes congenital myopathy with left ventricular non-compact cardiomyopathy.
Disrupted myosin cross-bridge cycling kinetics triggers muscle weakness in nebulin-related myopathy.
Distal myosin heavy chain-7 myopathy due to the novel transition c.5566G>A (p.E1856K) with high interfamilial cardiac variability and putative anticipation.
Down-regulation of MyoD gene expression in rat diaphragm muscle with heart failure.
Drosophila model of myosin myopathy rescued by overexpression of a TRIM-protein family member.
Dynamics of actomyosin interactions in relation to the cross-bridge cycle.
Dynamics of myosin degradation in intensive care unit-acquired weakness during severe critical illness.
Early fatal nemaline myopathy: case report and review.
Effect of HIV-1-related protein expression on cardiac and skeletal muscles from transgenic rats.
Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres.
Electrophoretic determination of the myosin/actin ratio in the diagnosis of critical illness myopathy.
Electrophysiologic techniques in critical illness-associated weakness.
Embryonic myosin heavy-chain mutations cause distal arthrogryposis and developmental myosin myopathy that persists postnatally.
Expression of the inclusion body myopathy 3 mutation in Drosophila depresses myosin function and stability and recapitulates muscle inclusions and weakness.
Gene-related protein surplus myopathies.
Heart failure alters MyoD and MRF4 expressions in rat skeletal muscle.
Hereditary myosin myopathies.
Homozygous mutation in MYH7 in myosin storage myopathy and cardiomyopathy.
Homozygous MYH7 R1820W mutation results in recessive myosin storage myopathy: Scapuloperoneal and respiratory weakness with dilated cardiomyopathy.
Homozygous recessive MYH2 mutation mimicking dominant MYH2 associated myopathy.
Human disease caused by loss of fast IIa myosin heavy chain due to recessive MYH2 mutations.
Human muscle proteins: analysis by two-dimensional electrophoresis.
Immunocytochemical analysis of myosin heavy chains in human fetal skeletal muscles.
Immunopathogenesis of dilated cardiomyopathies.
Immunophenotyping of congenital myopathies: disorganization of sarcomeric, cytoskeletal and extracellular matrix proteins.
Impaired autophagy, chaperone expression, and protein synthesis in response to critical illness interventions in porcine skeletal muscle.
Impaired Ca(2+) release contributes to muscle weakness in a rat model of critical illness myopathy.
Impaired muscle morphology in a Drosophila model of myosin storage myopathy was supressed by overexpression of an E3 ubiquitin ligase.
Induced shift in myosin heavy chain expression in myosin myopathy by endurance training.
Inflammation and perturbation of the l-carnitine system in heart failure.
Inherited muscular disorder in mutant Japanese quail (Coturnix coturnix japonica): an immunohistochemical study.
Inhibition of actomyosin ATPase by high concentrations of 5-hydroxytryptamine. Possible basis of lesion in 5HT-induced experimental myopathy.
Intrinsic tryptophan fluorescence identifies specific conformational changes at the actomyosin interface upon actin binding and ADP release.
Jumonji represses alpha-cardiac myosin heavy chain expression via inhibiting MEF2 activity.
Laing early onset distal myopathy: slow myosin defect with variable abnormalities on muscle biopsy.
Laing Myopathy: Report of 4 New Families With Novel MYH7 Mutations, Double Mutations, and Severe Phenotype.
Light chain 2 profile and activity of human ventricular myosin during dilated cardiomyopathy. Identification of a causal agent for impaired myocardial function.
Loss of actomyosin regulation in distal arthrogryposis myopathy due to mutant myosin binding protein-C slow.
Loss of function of myosin chaperones triggers Hsf1-mediated transcriptional response in skeletal muscle cells.
Mechanical Signaling in the Pathophysiology of Critical Illness Myopathy.
Millisecond Conformational Dynamics of Skeletal Myosin II Power Stroke Studied by High-Speed Atomic Force Microscopy.
Molecular and cellular defects of skeletal muscle in an animal model of acute quadriplegic myopathy.
Muscle cell and motor protein function in patients with a IIa myosin missense mutation (Glu-706 to Lys).
Muscular dystrophy and other myopathies. Troponin activity of natural actomyosin from skeletal muscle.
Mutation of the slow myosin heavy chain rod domain underlies hyaline body myopathy.
Mutations and sequence variation in the human myosin heavy chain IIa gene (MYH2).
Mutations at the Same Amino Acid in Myosin that Cause Either Skeletal or Cardiac Myopathy Have Distinct Molecular Phenotypes.
Mutations in either the essential or regulatory light chains of myosin are associated with a rare myopathy in human heart and skeletal muscle.
Mutations in MYH7 cause Multi-minicore Disease (MmD) with variable cardiac involvement.
Mutations in the beta-myosin rod cause myosin storage myopathy via multiple mechanisms.
Mutations in the slow skeletal muscle fiber myosin heavy chain gene (MYH7) cause laing early-onset distal myopathy (MPD1).
MYH2 myopathy, a new case expands the clinical and pathological spectrum of the recessive form.
MYH7 gene mutation in myosin storage myopathy and scapulo-peroneal myopathy.
MYH7 mutation associated with two phenotypes of myopathy.
MYH7-related disorders in two Bulgarian families: Novel variants in the same region associated with different clinical manifestation and disease penetrance.
MYH7-related myopathies: clinical, histopathological and imaging findings in a cohort of Italian patients.
Myo18b is essential for sarcomere assembly in fast skeletal muscle.
Myofibrillar protein and gene expression in acute quadriplegic myopathy.
Myogenic tremor - a novel tremor entity.
Myoimaging in the NGS era: the discovery of a novel mutation in MYH7 in a family with distal myopathy and core-like features - a case report.
Myopathies associated with myosin heavy chain mutations.
Myopathies resulting from mutations in sarcomeric proteins.
Myopathy in critically ill patients.
Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3.
Myosin autoantibodies detected by immunofluorescence.
Myosin Binding Protein-C Slow Phosphorylation is Altered in Duchenne Dystrophy and Arthrogryposis Myopathy in Fast-Twitch Skeletal Muscles.
Myosin changes in experimental 2,4-dichlorophenoxyacetate myopathy.
Myosin degeneration in a congenital myopathy.
Myosin filament 3D structure in mammalian cardiac muscle.
Myosin heavy chain IIa gene mutation E706K is pathogenic and its expression increases with age.
Myosin heavy chain isoform expression is not altered in the pectoralis major muscle in selenium-deficient chickens recovering from exudative diathetic myopathy.
Myosin isoforms and the mechanochemical cross-bridge cycle.
Myosin loss in denervated rat soleus muscle after dexamethasone treatment.
Myosin myopathy with external ophthalmoplegia associated with a novel homozygous mutation in MYH2.
Myosin storage (hyaline body) myopathy: a case report.
Myosin storage myopathy associated with a heterozygous missense mutation in MYH7.
Myosin Storage Myopathy in C. elegans and Human Cultured Muscle Cells.
Myosin storage myopathy mutations yield defective myosin filament assembly in vitro and disrupted myofibrillar structure and function in vivo.
Myosin storage myopathy with cardiomyopathy.
Myosin storage myopathy: slow skeletal myosin (MYH7) mutation in two isolated cases.
Myosin VI localization and expression in striated muscle pathology.
Myosinopathies: pathology and mechanisms.
N lines in a myopathy with myosin loss.
Neurological complications of sepsis: critical illness polyneuropathy and myopathy.
New cardiac and skeletal protein aggregate myopathy associated with combined MuRF1 and MuRF3 mutations.
Next generation sequencing reveals RYR1 mutations in a Chinese central core disease cohort.
Novel mutation in the MYH2 gene in a symptomatic neonate with a hereditary myosin myopathy.
Novel Mutations Widen the Phenotypic Spectrum of Slow Skeletal/?-Cardiac Myosin (MYH7) Distal Myopathy.
Novel phenotypic variant in the MYH7 spectrum due to a stop-loss mutation in the C-terminal region: a case report.
Novel slow-skeletal myosin (MYH7) mutation in the original myosin storage myopathy kindred.
Pathogenic Variants in the Myosin Chaperone UNC-45B Cause Progressive Myopathy with Eccentric Cores.
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Poor Myocardial Compaction in a Patient with Recessive MYL2 Myopathy.
Possible role for nitric oxide dysregulation in critical illness myopathy.
Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: Underlying mechanisms.
Protein aggregation in congenital myopathies.
Protein and mRNA levels of the myosin heavy chain isoforms Ibeta, IIa, IIx and IIb in type I and type II fibre-predominant rat skeletal muscles in response to chronic alcohol feeding.
Rapidly evolving myopathy with myosin-deficient muscle fibers.
Recessive MYH7-related myopathy in two families.
Recessive myosin myopathy with external ophthalmoplegia associated with MYH2 mutations.
Recurrent acute quadriplegic myopathy with myosin deficiency.
Research progress of myosin heavy chain genes in human genetic diseases.
Scoliosis surgery in a patient with "de novo" myosin storage myopathy.
Skeletal muscle wastage in Crohn's disease: a pathway shared with heart failure?
Skip residues modulate the structural properties of the myosin rod and guide thick filament assembly.
Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain.
Striking phenotypic variability in two familial cases of myosin storage myopathy with a MYH7 Leu1793pro mutation.
Structural basis for myopathic defects engendered by alterations in the myosin rod.
Symptomatic distal myopathy with cardiomyopathy due to a MYH7 mutation.
Target resequencing of neuromuscular disease-related genes using next-generation sequencing for patients with undiagnosed early-onset neuromuscular disorders.
The Effect of Nutritional Status in the Pathogenesis of Critical Illness Myopathy (CIM).
The effects of endurance training in persons with a hereditary myosin myopathy.
The Molecular Mechanisms of Mutations in Actin and Myosin that Cause Inherited Myopathy.
The role of immunocytochemistry in congenital myopathies.
The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill.
The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy.
The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins.
Thick and thin filament gene mutations in striated muscle diseases.
Thick filament diseases.
Toxic neuropathies and myopathies.
Ubiquitin expression in acute steroid myopathy with loss of myosin thick filaments.
Upregulation of the CaV 1.1-ryanodine receptor complex in a rat model of critical illness myopathy.
Variable phenotypic expression and onset in MYH14 distal hereditary motor neuropathy phenotype in a large, multigenerational North American family.
VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.
X-ray diffraction from flight muscle with a headless myosin mutation: implications for interpreting reflection patterns.
[Clinical assessment of serum myosin light chain I in patients with dilated cardiomyopathy]
[Distal myopathies]
[Myosin storage myopathy: a rare subtype of protein aggregate myopathies]
[The adaptation of histometry and immunohistochemical detection of fetal myosin as diagnostic methods for stress myopathy in swine]
[The amino acid composition of the myosin and actin of the muscles of animals with hereditary myopathies]
[The Development of Clinical and Morphological Manifestations of Chronic Alcoholic Myopathy in Men with Prolonged Alcohol Intoxication].
Muscular Disorders, Atrophic
Cessation of biomechanical stretch model of C2C12 cells models myocyte atrophy and anaplerotic changes in metabolism using non-targeted metabolomics analysis.
Specific changes in skeletal muscle myosin heavy chain composition in cardiac failure: differences compared with disuse atrophy as assessed on microbiopsies by high resolution electrophoresis.
[Effect of endurance training on the compositions of fiber types and myosin light chains in muscles under disuse atrophy]
[Skeletal musculature modifications and mechanisms of fatigue in chronic heart failure]
Muscular Dystrophies
3H leucine incorporation into myofibrils of normal and dystrophic mouse skeletal muscle.
Abnormal myosin heavy chain variant associated with avian muscular dystrophy.
Affinity proteomics within rare diseases: a BIO-NMD study for blood biomarkers of muscular dystrophies.
Altered cross-bridge properties in skeletal muscle dystrophies.
Biochemical changes in progressive muscular dystrophy. IX. Synthesis of native myosin, actin, and tropomyosin in the skeletal muscle of mouse as a function of muscular dystrophy.
Biochemical changes in progressive muscular dystrophy. XIV. Skeletal muscle myosin mRNA translatability in dystrophic mice.
Continued expression of neonatal myosin heavy chain in adult dystrophic skeletal muscle.
Development of muscle pathology in canine X-linked muscular dystrophy. I. Delayed postnatal maturation of affected and normal muscle as revealed by myosin isoform analysis and utrophin expression.
Distribution of cytoskeletal elements in cultured skin fibroblasts of patients with Duchenne's muscular dystrophy.
Distribution of myosin heavy chain isoforms in muscular dystrophy: insights into disease pathology.
Dystrophin deficiency in canine X-linked muscular dystrophy in Japan (CXMDJ) alters myosin heavy chain expression profiles in the diaphragm more markedly than in the tibialis cranialis muscle.
Expression of myosin isoforms and of desmin, vimentin and titin in Tunisian Duchenne-like autosomal recessive muscular dystrophy.
Expression profiling in the muscular dystrophies: identification of novel aspects of molecular pathophysiology.
Muscular dystrophy and other myopathies. Troponin activity of natural actomyosin from skeletal muscle.
Myosin expression in hypertrophied fast twitch and slow tonic muscles of normal and dystrophic chickens.
MYOSIN FROM MICE WITH HEREDITARY MUSCULAR DYSTROPHY.
Myosin heavy chain in avian muscular dystrophy corresponds to the neonatal isozyme.
Myosin isoforms in normal and dystrophic chickens.
Myosin light chain-1: genetic analysis of three variants found in fast white chicken muscle and investigation of linkage with the muscular dystrophy gene.
Proposed mechanism for the turnover of myosin and its relation to muscular dystrophy.
Recombinant cryptic human fibronectinase cleaves actin and myosin: substrate specificity and possible role in muscular dystrophy.
Restricted expression of cardiac myosin light chain 2A gene in muscular dystrophic condition.
Structure of myosin heavy chain in avian muscular dystrophy.
STUDIES OF MYOSIN IN HEREDITARY MUSCULAR DYSTROPHY IN MICE.
Sulfhydryl and amino acid composition of actin and myosin in hereditary muscular dystrophy of chickens.
Target resequencing of neuromuscular disease-related genes using next-generation sequencing for patients with undiagnosed early-onset neuromuscular disorders.
The interaction of unregulated actin and myosin in avian muscular dystrophy.
Trim32 is a ubiquitin ligase mutated in limb girdle muscular dystrophy type 2H that binds to skeletal muscle myosin and ubiquitinates actin.
Utrophin-dystrophin-deficient mice as a model for Duchenne muscular dystrophy.
[Clinical significance of serum cardiac myosin light chain I in patients with muscular dystrophy]
Muscular Dystrophies, Limb-Girdle
Muscle-Derived Proteins as Serum Biomarkers for Monitoring Disease Progression in Three Forms of Muscular Dystrophy.
Target resequencing of neuromuscular disease-related genes using next-generation sequencing for patients with undiagnosed early-onset neuromuscular disorders.
Trim32 is a ubiquitin ligase mutated in limb girdle muscular dystrophy type 2H that binds to skeletal muscle myosin and ubiquitinates actin.
Muscular Dystrophy, Duchenne
Actomyosin alterations in Duchenne muscular dystrophy.
Ca-activated neutral protease and its inhibitors: in vitro effect on intact myofibrils.
Decreased creatine kinase activity in cultured Duchenne dystrophic muscle cells.
Differential expression of myosin heavy chain isoforms in the masticatory muscles of dystrophin-deficient mice.
Early decrease of IIx myosin heavy chain transcripts in Duchenne muscular dystrophy.
Embryonic myosin is a regeneration marker to monitor utrophin-based therapies for DMD.
Expression of myosin heavy chain isoforms in Duchenne muscular dystrophy patients and carriers.
Fine structural histochemistry of myosin-ATPase activity in the skeletal muscles of Duchenne muscular dystrophy.
Human muscle proteins: analysis by two-dimensional electrophoresis.
Methylprednisolone selectively affects dystrophin expression in human muscle cultures.
Muscle protein analysis. II. Two-dimensional electrophoresis of normal and diseased human skeletal muscle.
Muscle-Derived Proteins as Serum Biomarkers for Monitoring Disease Progression in Three Forms of Muscular Dystrophy.
Myosin light chain components in single muscle fibers of Duchenne muscular dystrophy.
Myosin light chains in Duchenne dystrophy and paraplegic muscle.
Oxandrolone enhances skeletal muscle myosin synthesis and alters global gene expression profile in Duchenne muscular dystrophy.
Specific localization of nesprin-1-?2, the short isoform of nesprin-1 with a KASH domain, in developing, fetal and regenerating muscle, using a new monoclonal antibody.
Superprecipitation and adenosine triphosphatase activity of myosin B in Duchenne muscular dystrophy.
Target resequencing of neuromuscular disease-related genes using next-generation sequencing for patients with undiagnosed early-onset neuromuscular disorders.
[Clinical significance of serum cardiac myosin light chain I in patients with Duchenne muscular dystrophy]
[The development of serum myosin light chain-III assay and evaluation in Duchenne muscular dystrophy]
Muscular Dystrophy, Facioscapulohumeral
Late-onset autosomal dominant limb girdle muscular dystrophy and Paget's disease of bone unlinked to the VCP gene locus.
Muscular Dystrophy, Oculopharyngeal
The oculopharyngeal muscular dystrophy locus maps to the region of the cardiac alpha and beta myosin heavy chain genes on chromosome 14q11.2-q13.
Myalgia
Markers of inflammation and myofibrillar proteins following eccentric exercise in humans.
Myosin heavy chain isoforms influence surface EMG parameters: a study of the trapezius muscle in cleaners with and without myalgia and in healthy teachers.
Rapid adaptation to eccentric exercise-induced muscle damage.
Toxic neuropathies and myopathies.
Myasthenia Gravis
Acetylcholine receptors in human thymic myoid cells in situ: an immunohistological study.
Evaluation of myosin-reactive antibodies from a panel of myasthenia gravis patients.
Inhibition of myosin ATPase activity by human myasthenia gravis antibodies reactive with the acetylcholine receptor.
Myosin and actin containing cells in the human postnatal thymus. Ultrastructural and immunohistochemical findings in normal thymus and in myasthenia gravis.
Thymic B lymphocyte clones from patients with myasthenia gravis secrete monoclonal striational autoantibodies reacting with myosin, alpha actinin, or actin.
Unexpected cross-reactivity between myosin and a main immunogenic region (MIR) of the acetylcholine receptor by antisera obtained from myasthenia gravis patients.
[Humoral antibodies against human musculoskeletal myosin fractions in myasthenia gravis pseudoparalytica]
Myelodysplastic Syndromes
RNA sequencing reveals a unique fusion of the lysine (K)-specific methyltransferase 2A and smooth muscle myosin heavy chain 11 in myelodysplastic syndrome and acute myeloid leukemia.
Myocardial Infarction
A human monoclonal antibody obtained from EBV-transformed B cells with specificity for myosin.
Alterations in cardiac troponin subunits in myocardial infarction.
Applications of anticardiac myosin monoclonal antibodies in the diagnosis of heart disease.
Assay of serum cardiac myosin heavy chain fragments in patients with acute myocardial infarction: determination of infarct size and long-term follow-up.
Assessment of myocardial infarct size by serial changes in serum cardiac myosin light chain II in dogs.
Atrial and brain natriuretic peptides in cardiovascular diseases.
Bispecific enzyme-linked signal-enhanced immunoassay with subattomole sensitivity.
Ca2+ sensitivity change and troponin loss in cardiac natural actomyosin after coronary occlusion.
Calcium-induced structural changes in synthetic myosin filaments of vertebrate striated muscles.
Cardiac functional improvement in rats with myocardial infarction by up-regulating cardiac myosin light chain kinase with neuregulin.
Cardiac myosin binding protein-C is a potential diagnostic biomarker for myocardial infarction.
Cardiac myosin light chain-1 release in acute myocardial infarction is associated with scintigraphic estimates of myocardial scar.
Cellular autoimmunity to cardiac myosin in patients with a recent myocardial infarction.
Changes in serum testosterone levels after myocardial infarction.
Changes of cardiac structural proteins in myocardial infarction.
Circulating cardiac myosin light chains in patients with angina at rest: identification of a high risk subgroup.
Clinical assessment of serum myosin light chains in the diagnosis of acute myocardial infarction.
Comments on "Quantification of myocardial infarct size after coronary reperfusion by serum cardiac myosin light chain II in conscious dogs".
Comprehensive Characterization of Swine Cardiac Troponin T Proteoforms by Top-Down Mass Spectrometry.
Concentration time courses of troponin and myosin subunits after acute myocardial infarction.
Correlation of myocardial necrosis with kinetics of 111In-labeled myosin-specific antibody in isolated rabbit septum.
Deletion of cardiomyocyte mineralocorticoid receptor ameliorates adverse remodeling after myocardial infarction.
Detection of serum cardiac myosin light chains in acute experimental myocardial infarction: radioimmunoassay of cardiac myosin light chains.
Diagnosis of acute myocardial infarction by detection of circulating cardiac myosin light chains.
Different time courses of cardiac contractile proteins after acute myocardial infarction.
Early imaging of experimental myocardial infarction by intracoronary administraion of 131I-labelled anticardiac myosin (Fab')2 fragments.
Effect of anti-cardiac myosin antibody on prognosis of patients with acute myocardial infarction.
Effects of 10- to 12-day treatment with L-thyroxine in rats with myocardial infarction.
Effects of chronic dobutamine on cardiac mechanics and biochemistry after myocardial infarction in rats.
Effects of L-thyroxine in rats with chronic heart failure after myocardial infarction.
Effects of steroid treatment on release of cardiac myosin light chain II in acute myocardial infarction in dogs.
Evaluation of the protective effect of verapamil on reperfusion injury by 111In anticardiac myosin antibody in canine myocardial infarction.
Experimental myocardial infarct imaging following intravenous administration of iodine-131 labeled antibody (Fab')2 fragments specific for cardiac myosin.
Further evaluation of immunocytochemical staining in the diagnosis of early myocardial ischaemic/hypoxic damage.
Humoral immune response against contractile proteins (actin and myosin) during cardiovascular disease.
Identification of cardiac myosin binding protein C as a candidate biomarker of myocardial infarction by proteomic analysis.
Identification of human ventricular myosin heavy chain fragments with monoclonal antibody 2F4 in human sera after myocardial necrosis.
Imaging of myocardial infarction in dogs and humans using monoclonal antibodies specific for human myosin heavy chains.
Immunoradiometric assay of myosin heavy chain fragments in plasma for investigation of myocardial infarction.
Immunoradiometric assay of serum myosin as a marker of myocardial cell damage: methodological and clinical evaluation.
Immunoscintigraphy for detecting acute myocardial infarction without electrocardiographic changes.
Increase in cardiac myosin binding protein-C plasma levels is a sensitive and cardiac-specific biomarker of myocardial infarction.
Increase in serum cardiac myosin light chain I associated with elective percutaneous transluminal coronary angioplasty in patients with ischemic heart disease.
Increased expression and regional differences of atrial myosin light chain 1 in human ventricles with old myocardial infarction. Analyses using two monoclonal antibodies.
Independent prognostic value of serum creatine kinase isoenzyme MB mass, cardiac troponin T and myosin light chain levels in suspected acute myocardial infarction. Analysis of 28 months of follow-up in 196 patients.
Induction of cardiomyocyte apoptosis by anti-cardiac myosin heavy chain antibodies in patients with acute myocardial infarction.
Influence of reperfusion on serum concentrations of cytosolic creatine kinase and structural myosin light chains in acute myocardial infarction.
Level of ventricular myosin light chains 1 and 2 determined by ELISA in serum of patients with acute myocardial infarction.
Levels of ventricular myosin fragments in human sera after myocardial infarction, determined with monoclonal antibodies to myosin heavy chains.
Localization of cardiac myosin-specific antibody in myocardial infarction.
Losartan inhibits myosin isoform shift after myocardial infarction in rats.
Magnetic antibody-linked nanomatchmakers for therapeutic cell targeting.
Measurement of human ventricular myosin light chain-1 by monoclonal solid-phase enzyme immunoassay in patients with acute myocardial infarction.
Modification of myosin gene expression by imidapril in failing heart due to myocardial infarction.
Modification of myosin protein and gene expression in failing hearts due to myocardial infarction by enalapril or losartan.
Monoclonal antibodies specific for human cardiac myosin: selection, characterization and experimental myocardial infarct imaging.
Monoclonal antibody to cardiac myosin: imaging of experimental myocardial infarction.
Myocardial infarct imaging of antibodies to canine cardiac myosin with indium-111-diethylenetriamine pentaacetic acid.
Myocardial infarct size by serum troponin T and myosin light chain 1 concentration.
Myocardial infarct size from serum cardiac myosin light chain. Clinical and experimental studies.
Myocardial infarction and regulatory myosin light chain.
Myocardial uptake of antimyosin antibody compared with serum myosin light chain I levels in patients with myocardial infarction.
Myofibroblasts in reperfused myocardial infarcts express the embryonic form of smooth muscle myosin heavy chain (SMemb).
Myosin isoenzymes in normal and hypertrophied human hearts.
Myosin light chain I grade: a simple marker for the severity and prognosis of patients with acute myocardial infarction.
Myosin light chain phosphorylation in cardiac hypertrophy and failure due to myocardial infarction.
Myosin light chains release in acute myocardial infarction: non-invasive estimation of infarct size.
Myosin: a highly sensitive indicator of myocardial necrosis after cardiac operations.
Natural IgM Blockade Limits Infarct Expansion and Left Ventricular Dysfunction in a Swine Myocardial Infarct Model.
Overexpression of prostaglandin E2 EP4 receptor improves cardiac function after myocardial infarction.
Quantification of myocardial infarct size after coronary reperfusion by serum cardiac myosin light chain II in conscious dogs.
Quantifying cell death in the myocardium: myosin specific antibody in the evaluation of membrane defects.
Quantitative relationship between left ventricular function and serum cardiac myosin light chain I levels after coronary reperfusion in patients with acute myocardial infarction.
Radioimmunoassay of cardiac myosin light chain II in the serum following experimental myocardial infarction.
Radiolabelled monoclonal antibodies against human cardiac myosin.
Regional changes in cardiac structural proteins in myocardial infarction: biochemical and histologic correlates.
Regional reduction in ventricular norepinephrine after healing of experimental myocardial infarction in cats.
Regional variation in rat cardiac myosin isoenzymes and ATPase activity after infarction.
Regional variations in myosin heavy chain concentration after healing of experimental myocardial infarction in cats.
Relationship between energy liberation and utilization in ischemic cardiac muscle.
Serum cardiac myosin light chain II in acute myocardial infarction; distinctive pattern of its appearance and estimation of infarct size.
Serum cardiac troponin T in patients with acute myocardial infarction. Detection of coronary reperfusion and prediction of cardiac function.
Serum levels of cardiac troponin I and troponin T in estimating myocardial infarct size soon after reperfusion.
Thyroid hormone at supra-physiological dose optimizes cardiac geometry and improves cardiac function in rats with old myocardial infarction.
[Acute myocardial infarct: myosin-light-chain liberation and ventricular function]
[Antigen-binding lymphocytes in acute myocardial infarct]
[Assessment of perioperative myocardial damage based on circulating heavy chain myosin fragments]
[Biochemical assessment of the effects of coronary thrombolysis by serum cardiac myosin light chain levels]
[Biochemical diagnosis for acute myocardial infarction; myosin light chain]
[Biochemical markers for acute coronary syndromes]
[Ca2+-dependent phosphorylation and ATPase activity of cardiac muscle myosin in experimental myocardial infarction]
[Cells containing smooth-muscle myosin during healing of myocardial infarction in rats]
[Clinical assessment of human cardiac myosin light chain I in acute myocardial infarction]
[Clinical study on the time courses of serum myosin light chain I levels in patients with acute myocardial infarction: effect of intracoronary thrombolysis on serum myosin light chain I levels]
[Detection of cardiac myosin light chain I by monoclonal antibody in the patients with acute myocardial infarction]
[Determination of myocardial myosin in the diagnosis of myocardial infarction]
[Effect of riboxine on the ATPase activity and adenine nucleotide content in the myocardium in experimental myocardial infarct]
[Estimation of perioperative myocardial infarction in patients under aorto-coronary bypass grafts with plasma level of myosin light chain I and 201Tl SPECT]
[Evaluation of healing process in myocardial infarction by the time course of serum myosin light chain I: the effects of early reperfusion]
[Evaluation of the efficacy of intravenous fibrinolytic treatment in the acute phase of myocardial infarction. Value of the determination of human plasma cardiac myosin]
[Evaluation of the size of thrombolysed myocardial infarction by serum myosin determination]
[Fibronectin and fibrinogen/fibrin at the focus of an experimental myocardial infarct]
[Leukocytolysis with actomyosin in myocardial infarct]
[Mid-term prognostic value of plasma heavy-chain myosin in thrombolysed myocardial infarction]
[Myosin: a necrosis marker: update and trends]
[Reduction of myocardial infarct size by early intracoronary thrombolysis as assessed by serum cardiac myosin light chains and left ventricular function]
[Relationship between early peaking of serum myosin light chain 1 level and washout phenomenon of creatine kinase in acute myocardial infarction]
[The determination of myocardial necrosis in unstable angina by the immunoradiometric measurement of circulating myosin]
[The effect of myosin from the human myocardium on quantitative T-lymphocyte values--active rosettes in patients with myocardial infarct and stenocardia]
[The thrombocytolysis phenomenon in patients with myocardial infarct]
[Three-dimensional display and its quantification of exercise stress myocardial tomography using thallium-201]
[Time-course changes in serum myosin light chain 1 concentration and clinical implication in patients with reperfused acute myocardial infarction]
[Use of monoclonal antibodies against myosin light chain 1 for detecting corresponding antigens in the blood of patients with myocardial infarct]
[Usefulness of serum cardiac myosin light chain I for the estimation of acute myocardial infarction size]
Myocardial Ischemia
ATPase activity and proteolysis of human myocardial actomyosin in ischemia and hypertrophy.
Cardiac myosin autoantibodies and acute rejection after heart transplantation in patients with dilated cardiomyopathy.
Changes of myocardial myoglobin, myosin and creatine kinase in cases of sudden nocturnal death syndrome.
Coupling between myosin ATPase cycle and creatinine kinase cycle facilitates cardiac actomyosin sliding in vitro. A clue to mechanical dysfunction during myocardial ischemia.
Dissociation of myosin light chains and decreased myosin ATPase activity with acidification of synthetic myosin filaments: possible clues to the fate of myosin in myocardial ischemia and infarction.
Increase in serum cardiac myosin light chain I associated with elective percutaneous transluminal coronary angioplasty in patients with ischemic heart disease.
Myocardial adaptive changes and damage in ischemic heart disease.
Myosin light chain phosphorylation during regional myocardial ischemia.
Our experiences with measurement of new potential biomarkers in the diagnosis of latent forms of myocardial ischemia.
Subclass specificity of autoantibodies against myosin in patients with idiopathic dilated cardiomyopathy: pro-inflammatory antibodies in DCM patients.
Transcription-independent Induction of ERBB1 through Hypoxia-inducible Factor 2A Provides Cardioprotection during Ischemia and Reperfusion.
[Contractile activity of the myocardium in chronic coronary insufficiency]
[Effect of verapamil on the molecular characteristics of myocardial actomyosin in experimental ischemia]
[The Ca2+ reactivity and the subunit composition of myocardial actomyosin during the pyromecaine and pyrroxan treatment of experimental ischemia]
[The effect of myosin from the human myocardium on quantitative T-lymphocyte values--active rosettes in patients with myocardial infarct and stenocardia]
Myocardial Stunning
Myosin binding protein C is differentially phosphorylated upon myocardial stunning in canine and rat hearts-- evidence for novel phosphorylation sites.
Reduction in beta-myosin heavy chains in stunned myocardium as assessed by nondenaturing gel electrophoresis.
Myocarditis
11C-methionine PET of myocardial inflammation in a rat model of experimental autoimmune myocarditis.
A CCR1 antagonist prevents the development of experimental autoimmune myocarditis in association with T cell inactivation.
A human monoclonal antibody obtained from EBV-transformed B cells with specificity for myosin.
A longitudinal study of antibody responses to selected host antigens in rheumatic fever and rheumatic heart disease.
A New Mouse Model of Chronic Myocarditis Induced by Recombinant Bacille Calmette-Guèrin Expressing a T-Cell Epitope of Cardiac Myosin Heavy Chain-?.
A novel class II-binding motif selects peptides that mediate organ-specific autoimmune disease in SWXJ, SJL/J, and SWR/J mice.
A novel experimental model of giant cell myocarditis induced in rats by immunization with cardiac myosin fraction.
A peptide fragment of beta cardiac myosin heavy chain (beta-CMHC) can provoke autoimmune myocarditis as well as the corresponding alpha cardiac myosin heavy chain (alpha-CMHC) fragment.
A spontaneous model for autoimmune myocarditis using the human MHC molecule HLA-DQ8.
Advantage of recombinant technology for the identification of cardiac myosin epitope of severe autoimmune myocarditis in Lewis rats.
Allogeneic administration of fetal membrane-derived mesenchymal stem cells attenuates acute myocarditis in rats.
Amelioration of myocarditis by HVEM-overexpressing dendritic cells through induction of IL-10-producing cells.
Amiodarone minimizes experimental autoimmune myocarditis in rats.
An ultrastructural study on experimental autoimmune myocarditis with special reference to effector cells.
Analysis of mitochondrial antigens reveals inner membrane succinate dehydrogenase flavoprotein subunit as autoantigen to antibodies in anti-M7 sera.
Angiotensin II type 1 receptor blocker, valsartan, prevented cardiac fibrosis in rat cardiomyopathy after autoimmune myocarditis.
Animal models for autoimmune myocarditis and autoimmune thyroiditis.
Anti-CD2 monoclonal antibodies prevent the induction of experimental autoimmune myocarditis.
Anti-human cardiac myosin autoantibodies in Kawasaki syndrome.
Anti-inflammatory role of obestatin in autoimmune myocarditis.
Antibodies against myosin in sera of patients with idiopathic paroxysmal atrial fibrillation.
Antimyosin autoantibodies are associated with deterioration of systolic and diastolic left ventricular function in patients with chronic myocarditis.
Attenuation of experimental autoimmune myocarditis by blocking activated T cells through inducible costimulatory molecule pathway.
Attenuation of experimental autoimmune myocarditis by si-RNA mediated CD40 silencing.
Autoantibodies against human ventricular myosin in sera of patients with acute and chronic myocarditis.
Autoantibodies specific for the cardiac myosin isoform are found in mice susceptible to Coxsackievirus B3-induced myocarditis.
Autoantibodies to cardiac myosin in mouse cytomegalovirus myocarditis.
Autoimmune determinants of rheumatic carditis: localization of epitopes in human cardiac myosin.
Autoimmune myocarditis does not require B cells for antigen presentation.
Autoimmune myocarditis, valvulitis, and cardiomyopathy.
Autoimmune myocarditis.
Autoimmunity Against the Heart and Cardiac Myosin in Children With Myocarditis.
Beta2-Adrenergic agonists suppress rat autoimmune myocarditis: potential role of beta2-adrenergic stimulants as new therapeutic agents for myocarditis.
Cannabidiol limits Tcell-mediated chronic autoimmune myocarditis: implications to autoimmune disorders and organ transplantation.
Cardiac alpha-myosin heavy chains differ in their induction of myocarditis. Identification of pathogenic epitopes.
Cardiac autoantibodies to myosin and other heart-specific autoantigens in myocarditis and dilated cardiomyopathy.
Cardiac muscle cell damage through autoimmune mechanism--can cardiac proteins provoke autoimmune myocarditis?
Cardiac myosin and autoimmune myocarditis.
Cardiac myosin and the TH1/TH2 paradigm in autoimmune myocarditis.
Cardiac myosin autoimmunity in acute Chagas' heart disease.
Cardiac myosin induces myocarditis in genetically predisposed mice.
Cardiac myosin-induced myocarditis as a model of postinfectious autoimmunity.
Cardiac myosin-induced myocarditis. Heart autoantibodies are not involved in the induction of the disease.
Cardiac myosin-induced myocarditis: target recognition by autoreactive T cells requires prior activation of cardiac interstitial cells.
Cardiac myosin-Th17 responses promote heart failure in human myocarditis.
Cardioprotective effects of omega 3 fatty acids from fish oil and it enhances autoimmunity in porcine cardiac myosin-induced myocarditis in the rat model.
Cardiosphere-Derived Cells Attenuate Inflammation, Preserve Systolic Function, and Prevent Adverse Remodeling in Rat Hearts With Experimental Autoimmune Myocarditis.
Cellular autoimmunity to cardiac myosin in patients with a recent myocardial infarction.
Cellular infiltrate, major histocompatibility antigen expression and immunopathogenic mechanisms in cardiac myosin-induced myocarditis.
Changes in perfusion and fatty acid metabolism of rat heart with autoimmune myocarditis.
Changes in serum cardiac myosin light chain 1 levels in children with fulminant myocarditis during continuous blood purification.
Characteristics of giant cells and factors related to the formation of giant cells in myocarditis.
Characterization of murine autoimmune myocarditis induced by self and foreign cardiac myosin.
Characterization of T cells infiltrating the heart in rats with experimental autoimmune myocarditis. Their similarity to extrathymic T cells in mice and the site of proliferation.
Chinese medicinal herb Radix Astragali suppresses cardiac contractile dysfunction and inflammation in a rat model of autoimmune myocarditis.
Chronic myocarditis induced by T cells reactive to a single cardiac myosin peptide: persistent inflammation, cardiac dilatation, myocardial scarring and continuous myocyte apoptosis.
Clinical significance and pathogenic role of anti-cardiac myosin autoantibody in dilated cardiomyopathy.
Comparative effects of torasemide and furosemide on gap junction proteins and cardiac fibrosis in a rat model of dilated cardiomyopathy.
Comparison of angiotensin converting enzyme inhibition and angiotensin II receptor blockade for the prevention of experimental autoimmune myocarditis.
Consequences of unlocking the cardiac myosin molecule in human myocarditis and cardiomyopathies.
Coxsackievirus B3 infection leads to the generation of cardiac myosin heavy chain-?-reactive CD4 T cells in A/J mice.
Coxsackievirus B3 infection promotes generation of myeloid dendritic cells from bone marrow and accumulation in the myocardium.
Coxsackievirus B3-induced myocarditis. Characterization of stable attenuated variants that protect against infection with the cardiovirulent wild-type strain.
Coxsackievirus B3-induced myocarditis: infection of females during the estrus phase of the ovarian cycle leads to activation of T regulatory cells.
Coxsackievirus induced myocarditis in mice: cardiac myosin autoantibodies do not cross-react with the virus.
Coxsackievirus-induced chronic myocarditis in murine models.
Critical role for monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha in induction of experimental autoimmune myocarditis and effective anti-monocyte chemoattractant protein-1 gene therapy.
Cryptic epitope identified in rat and human cardiac myosin S2 region induces myocarditis in the Lewis rat.
Curcumin ameliorates experimental autoimmune acute myocarditis in rats as evidenced by decrease in thioredoxin immunoreactivity.
Cytokines that regulate autoimmune myocarditis.
Depressed unloaded sarcomere shortening velocity in acute murine coxsackievirus myocarditis: myocardial remodelling in the absence of necrosis or hypertrophy.
Detection of cardiac myosin heavy chain-?-specific CD4 cells by using MHC class II/IA(k) tetramers in A/J mice.
Direct staining with major histocompatibility complex class II dextramers permits detection of antigen-specific, autoreactive CD4 T cells in situ.
Dissecting mechanisms of innate and acquired immunity in myocarditis.
Effects of atorvastatin on the Th1/Th2 polarization of ongoing experimental autoimmune myocarditis in Lewis rats.
Effects of hepatocyte growth factor in myocarditis rats induced by immunization with porcine cardiac myosin.
Effects of zileuton on the development of autoimmune myocarditis in an experimental rat model.
Erythromycin treatment suppresses myocardial injury in autoimmune myocarditis in rats via suppression of superoxide production.
Exacerbation of autoimmune myocarditis by an immune checkpoint inhibitor is dependent on its time of administration in mice.
Experimental autoimmune myocarditis and its pathomechanism.
Experimental autoimmune myocarditis in A/J mice is an interleukin-4-dependent disease with a Th2 phenotype.
Experimental giant cell myocarditis induced by cardiac myosin immunization.
Experimentally-induced autoimmune myocarditis: production of heart myosin-specific autoantibodies within the inflammatory infiltrate.
Expression of coxsackievirus and adenovirus receptor in hearts of rats with experimental autoimmune myocarditis.
Expression of myosin-class II major histocompatibility complexes in the normal myocardium occurs before induction of autoimmune myocarditis.
Fatal Eosinophilic Myocarditis Develops in the Absence of IFN-? and IL-17A.
Fc receptor-mediated inhibitory effect of immunoglobulin therapy on autoimmune giant cell myocarditis: concomitant suppression of the expression of dendritic cells.
Folate Receptor ? Targeted PET Imaging of Macrophages in Autoimmune Myocarditis.
FR167653 suppresses the progression of experimental autoimmune myocarditis.
From infection to autoimmunity.
Galectin-3 deficiency enhances type 2 immune cell-mediated myocarditis in mice.
Generation of humanized mice susceptible to peptide-induced inflammatory heart disease.
Genetic control of autoimmune myocarditis mediated by myosin-specific antibodies.
Genetic control of Coxsackievirus B3-induced heart-specific autoantibodies associated with chronic myocarditis.
Growth hormone interferes with the progression of myocarditis in rats.
Heart-specific autoantibodies induced by Coxsackievirus B3: identification of heart autoantigens.
Hepatocyte growth factor ameliorates the progression of experimental autoimmune myocarditis: a potential role for induction of T helper 2 cytokines.
Human umbilical cord mesenchymal stem cells alleviate acute myocarditis by modulating endoplasmic reticulum stress and extracellular signal regulated 1/2-mediated apoptosis.
Humoral immune response against contractile proteins (actin and myosin) during cardiovascular disease.
Identification and characterization of the antigen presenting cell in rat autoimmune myocarditis: evidence of bone marrow derivation and non-requirement for MHC class I compatibility with pathogenic T cells.
Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice.
Identification of myocarditogenic peptides derived from cardiac myosin capable of inducing experimental allergic myocarditis in the Lewis rat. The utility of a class II binding motif in selecting self-reactive peptides.
Identification of novel mimicry epitopes for cardiac myosin heavy chain-? that induce autoimmune myocarditis in A/J mice.
Immune tolerance to cardiac myosin induced by anti-CD4 monoclonal antibody in autoimmune myocarditis rats.
Immunoglobulin G3 cardiac myosin autoantibodies correlate with left ventricular dysfunction in patients with dilated cardiomyopathy: immunoglobulin G3 and clinical correlates.
Immunoglobulin treatment suppressed adoptively transferred autoimmune myocarditis in severe combined immunodeficient mice.
Immunohistological analyses of myocardial infiltrating cells in various animal models of myocarditis.
Impaired thymic tolerance to ?-myosin directs autoimmunity to the heart in mice and humans.
In situ detection of autoreactive CD4 T cells in brain and heart using major histocompatibility complex class II dextramers.
In vivo deposition of myosin-specific autoantibodies in the hearts of mice with experimental autoimmune myocarditis.
In vivo lymphocyte-mediated myocardial injuries demonstrated by adoptive transfer of experimental autoimmune myocarditis.
Increased phosphorylation of Ca(2+) handling proteins as a proarrhythmic mechanism in myocarditis.
Induction of antigen specific peripheral humoral tolerance to cardiac myosin does not prevent CB3-mediated autoimmune myocarditis.
Induction of autoimmune myocarditis in interleukin-2-deficient mice.
Induction of multiple heart autoantibodies in mice with coxsackievirus B3- and cardiac myosin-induced autoimmune myocarditis.
Induction of myocarditis and valvulitis in lewis rats by different epitopes of cardiac myosin and its implications in rheumatic carditis.
Inhibition of experimental autoimmune myocarditis: peripheral deletion of TcR Vbeta 8.1, 8.2(+) CD4(+) T cells in TLR-4 deficient mice.
Inhibition of NF-kappaB activation by a novel IKK inhibitor reduces the severity of experimental autoimmune myocarditis via suppression of T-cell activation.
Inhibitory effects of vesnarinone in the progression of myocardial damage in experimental autoimmune myocarditis in rats.
Interferon-? causes cardiac myocyte atrophy via selective degradation of myosin heavy chain in a model of chronic myocarditis.
Interleukin-12 receptor/STAT4 signaling is required for the development of autoimmune myocarditis in mice by an interferon-gamma-independent pathway.
Intravital microscopy -A novel toolin characterizing congestive heart failurein experimental autoimmune myocarditis.
Involvement of Sema4A in the progression of experimental autoimmune myocarditis.
Lessons from animal experiments in myocarditis.
Lisinopril has a cardio-protective effect on experimental acute autoimmune myocarditis in rats.
Liver-Specific siRNA-Mediated Stat3 or C3 Knockdown Improves the Outcome of Experimental Autoimmune Myocarditis.
Localization of CD8 T cell epitope within cardiac myosin heavy chain-?334-352 that induces autoimmune myocarditis in A/J mice.
Localization of porcine cardiac myosin epitopes that induce experimental autoimmune myocarditis.
Longitudinal 18F-FDG PET imaging in a rat model of autoimmune myocarditis.
Low-molecular-weight tumor necrosis factor receptor p55 controls induction of autoimmune heart disease.
Luminex-Coupled EliFACS: A Multiparametric Method to Enumerate and Functionally Characterize Antigen-Specific T cells in Human Peripheral Blood.
Mercury and autoimmunity: implications for occupational and environmental health.
Microarray analysis reveals the role of matrix metalloproteinases in mouse experimental autoimmune myocarditis induced by cardiac myosin peptides.
Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy.
Molecular analysis of polyreactive monoclonal antibodies from rheumatic carditis: human anti-N-acetylglucosamine/anti-myosin antibody V region genes.
Molecular magnetic resonance imaging of activated platelets allows noninvasive detection of early myocarditis in mice.
Molecular mimicry in the autoimmune pathogenesis of rheumatic heart disease.
Monomethoxypolyethylene glycol-modified cardiac myosin treatment blocks the active and passive induction of experimental autoimmune myocarditis.
Mouse cytomegalovirus infection induces antibodies which cross-react with virus and cardiac myosin: a model for the study of molecular mimicry in the pathogenesis of viral myocarditis.
Mouse models of autoimmune diseases - autoimmune myocarditis.
Myocardial infarction triggers chronic cardiac autoimmunity in type 1 diabetes.
Myocarditis-inducing epitope of myosin binds constitutively and stably to I-Ak on antigen-presenting cells in the heart.
Myocarditis: Infection Versus Autoimmunity.
Myocarditogenic epitopes and autoimmune myocarditis.
Myosin autoimmunity is not essential for cardiac inflammation in acute Chagas' disease.
Myosin-induced acute myocarditis is a T cell-mediated disease.
Myosin-primed tolerogenic dendritic cells ameliorate experimental autoimmune myocarditis.
Nasal administration of cardiac myosin suppresses autoimmune myocarditis in mice.
Nasal cardiac myosin peptide treatment and OX40 blockade protect mice from acute and chronic virally-induced myocarditis.
Neutralization of endogenous tumor necrosis factor ameliorates the severity of myosin-induced myocarditis.
Nitric oxide contributes to the progression of myocardial damage in experimental autoimmune myocarditis in rats.
Non-invasive assessment of early and acute myocarditis in a rat model using cardiac magnetic resonance tissue tracking analysis of myocardial strain.
Noninvasive assessment of cardiac abnormalities in experimental autoimmune myocarditis by magnetic resonance microscopy imaging in the mouse.
Oral Tolerization with Cardiac Myosin Peptide (614-629) Ameliorates Experimental Autoimmune Myocarditis: Role of Stat 6 Genes in BALB/CJ Mice.
Pathogenesis and preventive and therapeutic trials in an animal model of dilated cardiomyopathy induced by a virus.
Pathogenesis of myocarditis and dilated cardiomyopathy.
Pathology and pathogenesis of rheumatic heart disease.
Pathophysiology of viral myocarditis: the role of humoral immune response.
Peroxisome proliferator-activated receptor-gamma ligands ameliorate experimental autoimmune myocarditis associated with inhibition of self-sensitive T cells.
Persistence of virus and viral genome in myocardium after coxsackievirus B3-induced murine myocarditis.
Prevention of autoimmune myocarditis through the induction of antigen-specific peripheral immune tolerance.
Prevention of myosin-induced autoimmune myocarditis in mice by anti-L3T4 monoclonal antibody.
Priming the immune system for heart disease: a perspective on group A streptococci.
Protection against experimental autoimmune myocarditis is mediated by interleukin-10-producing T cells that are controlled by dendritic cells.
Protective mechanisms of berberine against experimental autoimmune myocarditis in a rat model.
Quantification and characterization of myosin peptide-specific CD4+ T cells in autoimmune myocarditis.
Quantification of antimyosin antibodies in experimental myocarditis by a new solid phase fluorometric assay.
Quantifying cell death in the myocardium: myosin specific antibody in the evaluation of membrane defects.
Quercetin offers cardioprotection against progression of experimental autoimmune myocarditis by suppression of oxidative and endoplasmic reticulum stress via endothelin-1/MAPK signalling.
Rapamycin ameliorates experimental autoimmune myocarditis.
Rat dilated cardiomyopathy after autoimmune giant cell myocarditis.
Recent advances in the management of autoimmune myocarditis: insights from animal studies.
Recombinant cardiac myosin fragment induces experimental autoimmune myocarditis via activation of Th1 and Th17 immunity.
Reduced unloaded sarcomere shortening velocity and a shift to a slower myosin isoform in acute murine coxsackievirus myocarditis.
Regulation of inflammation and myocardial fibrosis in experimental autoimmune myocarditis.
Resveratrol ameliorates experimental autoimmune myocarditis.
Rethinking Molecular Mimicry in Rheumatic Heart Disease and Autoimmune Myocarditis: Laminin, Collagen IV, CAR, and B1AR as Initial Targets of Disease.
Rheumatic fever pathogenesis: Approach in research needs change.
Serial changes in 14C-deoxyglucose and 201Tl uptake in autoimmune myocarditis in rats.
Serum cardiac troponin T and creatine kinase-MB elevations in murine autoimmune myocarditis.
Sex-specific signaling through Toll-Like Receptors 2 and 4 contributes to survival outcome of Coxsackievirus B3 infection in C57Bl/6 mice.
Significance of pericardial cytokines in giant cell myocarditis in rats--pathological comparison to viral myocarditis in mice.
Single-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis.
Spontaneous myocarditis mimicking human disease occurs in the presence of an appropriate MHC and non-MHC background in transgenic mice.
Strain difference in rats with experimental giant cell myocarditis.
Streptococcal M protein peptide with similarity to myosin induces CD4+ T cell-dependent myocarditis in MRL/++ mice and induces partial tolerance against coxsakieviral myocarditis.
Suppression of inflammation in rat autoimmune myocarditis by S100A8/A9 through modulation of the proinflammatory cytokine network.
Suppression of myosin-induced and adoptively transferred myocarditis by prior treatment with complete Freund's adjuvant.
Susceptibility to autoimmune myocarditis is associated with intrinsic differences in CD4(+) T cells.
T cell mimicry and epitope specificity of cross-reactive T cell clones from rheumatic heart disease.
T cell mimicry in inflammatory heart disease.
T cells in cardiac myosin-induced myocarditis.
T cells in coxsackievirus-induced myocarditis.
T-Cell-dependent antibody response to the dominant epitope of streptococcal polysaccharide, N-acetyl-glucosamine, is cross-reactive with cardiac myosin.
Telmisartan ameliorates experimental autoimmune myocarditis associated with inhibition of inflammation and oxidative stress.
Th1-type immune responses by Toll-like receptor 4 signaling are required for the development of myocarditis in mice with BCG-induced myocarditis.
The effect of early and late treatment with the tyrphostin AG-556 on the progression of experimental autoimmune myocarditis.
The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected]
The pathogenesis of postinfectious myocarditis.
The possible value of synthetic peptides in the diagnosis and therapy of myocarditis and dilated cardiomyopathy.
The protective effects of taurine on experimental autoimmune myocarditis.
The significance of autoimmunity in myocarditis.
Torasemide, a long-acting loop diuretic, reduces the progression of myocarditis to dilated cardiomyopathy.
Transplantation of mesenchymal stem cells attenuates myocardial injury and dysfunction in a rat model of acute myocarditis.
Upregulation of thioredoxin (TRX) expression in giant cell myocarditis in rats.
Viral myocarditis.
Whole-body hyperthermia attenuates experimental autoimmune myocarditis in the rat.
Wild isolates of murine cytomegalovirus induce myocarditis and antibodies that cross-react with virus and cardiac myosin.
[Antimyosin scintigraphy for diagnosis and follow-up of patients with clinically suspected myocarditis]
[Autoantibodies against cardiac myosin in patients with myocarditis and dilated cardiomyopathy]
[Diagnostic Values and Reliability of Cardiac Magnetic Resonance Tissue Tracking 2D and 3D Strain Assessments for Experimental Autoimmune Myocarditis in Rats].
[Dynamic of myocarditis development in rats after injection of cardiac myosine combined with IFA].
[Dynamics of autoimmune myocarditis development in rats].
[Effects of humoral factors on left ventricular remodeling under chronic heart failure]
[The action of a number of cardiac glycosides on an isolated system of myocardial contractile proteins in heart failure due to toxic-allergic myocarditis. The molecular mechanism]
Myoepithelioma
5-Azacytidine induction of stable myoepithelial and acinar cells from a human salivary intercalated duct cell clone.
Immunohistochemical identification of actomyosin-containing (myoepithelial) cells in non-neoplastic and neoplastic tissues.
Induction of other differentiation stages in neoplastic epithelial duct and myoepithelial cells from the human salivary gland grown in athymic nude mice.
Myoepitheliomas and myoepithelial adenomas of salivary gland origin. Immunohistochemical evaluation of filament proteins, S-100 alpha and beta, glial fibrillary acidic proteins, neuron-specific enolase, and lactoferrin.
Myoma
Overexpression of myosin is associated with the development of uterine myoma.
Myopathies, Nemaline
Alpha-actinin and myosin light chains in congenital nemaline myopathy.
Characteristics of myosin in nemaline myopathy.
Congenital myopathies.
Congenital myopathies: an update.
Congenital nemaline myopathy. II. Quantitative changes in alpha-actinin and myosin in skeletal muscle.
Fast to slow change of myosin in nemaline myopathy: electrophoretic and immunologic evidence.
Fast to slow change of myosin in nemaline rod myopathy.
Modulating myosin restores muscle function in a mouse model of nemaline myopathy.
Muscle protein analysis. II. Two-dimensional electrophoresis of normal and diseased human skeletal muscle.
Mutations in Drosophila Myosin Rod Cause Defects in Myofibril Assembly.
Myosin polymorphism in human skeletal muscles.
Nemaline myopathy.
Slow myosin heavy chain isozyme in nemaline myopathy.
Target resequencing of neuromuscular disease-related genes using next-generation sequencing for patients with undiagnosed early-onset neuromuscular disorders.
[A case of nemaline myopathy with uniform type I fiber and unique hybrid pattern of myosin light chains]
Myopathies, Structural, Congenital
A novel MYH7 mutation links congenital fiber type disproportion and myosin storage myopathy.
Centronuclear myopathy heterogeneity: distinction of clinical types by myosin isoform patterns.
Congenital myopathies: an update.
Distinct contractile protein profile in congenital myotonic dystrophy and X-linked myotubular myopathy.
Fetus-like dystrophin expression and other cytoskeletal protein abnormalities in centronuclear myopathies.
Immunophenotyping of congenital myopathies: disorganization of sarcomeric, cytoskeletal and extracellular matrix proteins.
Normal innervation and differentiation of X-linked myotubular myopathy muscle cells in a nerve-muscle coculture system.
Target resequencing of neuromuscular disease-related genes using next-generation sequencing for patients with undiagnosed early-onset neuromuscular disorders.
myosin atpase deficiency
Increased chitin synthesis in response to type II myosin deficiency in Saccharomyces cerevisiae.
Proplatelet formation deficit and megakaryocyte death contribute to thrombocytopenia in Myh9 knockout mice.
Recurrent acute quadriplegic myopathy with myosin deficiency.
Myositis
Adhesion molecule expression in experimental myositis.
Autoantibodies in canine masticatory muscle myositis recognize a novel myosin binding protein-C family member.
C-protein in the skeletal muscle induces severe autoimmune polymyositis in Lewis rats.
Effect of myosin B on guinea pig muscles--light microscopic and immunological aspects.
Evidence for MHC I-restricted CD8(+) T-cell-mediated immunopathology in canine masticatory muscle myositis and polymyositis.
Experimental allergic myositis in SJL/J mice immunized with rabbit myosin B fraction: immunohistochemical analysis and transfer.
Experimental allergic myositis in SJL/J mouse. Reappraisal of immune reaction based on changes after single immunization.
Experimental allergic myositis: strain 13 guinea pig immunised with rabbit myosin B fraction.
Experimental allergic myositis: ultrastructural, histochemical, immunological and immunohistochemical studies.
Experimental autoimmune myositis in SJL/J mice produced by immunization with syngeneic myosin B fraction. Transfer by both immunoglobulin G and T cells.
Inflammatory myopathy--early diagnosis and management by serum myosin light chains measurements.
Inhibition of CX3CL1 (fractalkine) improves experimental autoimmune myositis in SJL/J mice.
Interleukin-37 (IL-37) Suppresses Pertussis Toxin-Induced Inflammatory Myopathy in a Rat Model.
Intravenous immunoglobulin prevents experimental autoimmune myositis in SJL mice by reducing anti-myosin antibody and by blocking complement deposition.
Myosin-induced autoimmune polymyositis in the rat.
Persistent upregulation of the ?-tubulin tubb6, linked to muscle regeneration, is a source of microtubule disorganization in dystrophic muscle.
Proliferative myositis and fasciitis. Report of five cases with an ultrastructural and immunohistochemical study.
Retinoid ameliorates experimental autoimmune myositis, with modulation of Th cell differentiation and antibody production in vivo.
Role of regulatory T cells in a new mouse model of experimental autoimmune myositis.
Safety evaluation of GX-12. A new DNA vaccine for HIV infection in rodents.
Skeletal muscle myosin is the autoantigen for experimental autoimmune myositis.
Toxic neuropathies and myopathies.
Myotonia
Fast to slow transition induced by experimental myotonia in rat EDL muscle.
Isomyosin distribution in skeletal muscles of normal and myotonic goats.
Myotonic Dystrophy
Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics.
Cdc42 antagonizes inductive action of cAMP on cell shape, via effects of the myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) on myosin light chain phosphorylation.
Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase.
Distinct contractile protein profile in congenital myotonic dystrophy and X-linked myotubular myopathy.
DMPK is a New Candidate Mediator of Tumor Suppressor p53-Dependent Cell Death.
DOCK8 Protein Regulates Macrophage Migration through Cdc42 Protein Activation and LRAP35a Protein Interaction.
Expression of late myogenic differentiation markers in sarcoplasmic masses of patients with myotonic dystrophy.
Immunological properties of myosin in myotonic dystrophy.
Late-onset autosomal dominant limb girdle muscular dystrophy and Paget's disease of bone unlinked to the VCP gene locus.
Myosin heavy chain class I molecules are normally expressed in myotonic dystrophy.
Myosin light chains and muscle pathology.
Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization.
Promiscuous expression of myosin in myotonic dystrophy.
Protein synthesis in muscle cultures from patients with myotonic dystrophy. Influence of A23187 ionophore and calcium: preliminary investigation.
Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization.
Myotoxicity
Toxic and Endocrine Myopathies.
Toxic neuropathies and myopathies.
Myxoma
Cardiac myxoma. A retrospective immunohistochemical study.
Cardiac myxomas. An immunohistochemical study using endothelial, histiocytic, and smooth-muscle cell markers.
In situ interleukin-6 transcription in embryonic nonmuscle myosin heavy chain expressing immature mesenchyme cells of cardiac myxoma.
Inherited disposition to cardiac myxoma development.
Nasal Obstruction
Myosin heavy chain expression and muscle adaptation to chronic oral breathing in rat.
Temporary forced oral breathing affects neonates oxygen consumption, carbon dioxide elimination, diaphragm muscles structure and physiological parameters.
Neoplasm Metastasis
4-Hydroxyacetophenone modulates the actomyosin cytoskeleton to reduce metastasis.
Aberrant Myosin 1b Expression Promotes Cell Migration and Lymph Node Metastasis of HNSCC.
Actin as a Target to Reduce Cell Invasiveness in Initial Stages of Metastasis.
Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis.
Akt2/ZEB2 may be a biomarker for exfoliant cells in ascitic fluid in advanced grades of serous ovarian carcinoma.
AQP3 Increases Intercellular Cohesion in NSCLC A549 Cell Spheroids through Exploratory Cell Protrusions.
Asymmetric mode of Ca²?-S100A4 interaction with nonmuscle myosin IIA generates nanomolar affinity required for filament remodeling.
Binding to intracellular targets of the metastasis-inducing protein, S100A4 (p9Ka).
Cancer Cells Resist Mechanical Destruction in Circulation via RhoA/Actomyosin-Dependent Mechano-Adaptation.
Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis.
Capping protein regulator and myosin 1 linker 3 regulates transcription of key cytokines in activated phagocytic cells.
CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis.
Clinical significance of myosin in colorectal cancer.
Effect of Mts1 on the structure and activity of nonmuscle myosin II.
Elevated expression of myosin X in tumours contributes to breast cancer aggressiveness and metastasis.
Expression and prognostic significance of MYL9 in esophageal squamous cell carcinoma.
Expression of cytoskeletal components in melanocytic skin lesions. An immunohistochemical study.
HSP47 promotes metastasis of breast cancer by interacting with myosin IIA via the unfolded protein response transducer IRE1?.
Interaction of metastasis associated Mts1 protein with nonmuscle myosin.
Interaction of metastasis-inducing S100A4 protein in vivo by fluorescence lifetime imaging microscopy.
Long non-coding RNA (LncRNA) MRPL23-AS1 promotes tumor progression and carcinogenesis in osteosarcoma by activating Wnt/?-catenin signaling via inhibiting microRNA miR-30b and upregulating myosin heavy chain 9 (MYH9).
Long non-coding RNA TUSC8 inhibits breast cancer growth and metastasis via miR-190b-5p/MYLIP axis.
Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines.
Mechanics and Actomyosin-Dependent Survival/Chemoresistance of Suspended Tumor Cells in Shear Flow.
MYBPH inhibits vascular smooth muscle cell migration and attenuates neointimal hyperplasia in a rat carotid balloon-injury model.
MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis.
MYLK promotes hepatocellular carcinoma progression through regulating cytoskeleton to enhance epithelial-mesenchymal transition.
Myosin 5a regulates tumor migration and epithelial-mesenchymal transition in esophageal squamous cell carcinoma: utility as a prognostic factor.
Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility.
Myosin isoform expressed in metastatic prostate cancer stimulates cell invasion.
Myosin light chain kinase inhibitors can block invasion and adhesion of human pancreatic cancer cell lines.
Myosin Va plays essential roles in maintaining normal mitosis, enhancing tumor cell motility and viability.
Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis.
Non-muscle myosin II is an independent predictor of overall survival for cystectomy candidates with early-stage bladder cancer.
Non-muscle myosin IIA differentially regulates intestinal epithelial cell restitution and matrix invasion.
Non-muscle myosin IIB is critical for nuclear translocation during 3D invasion.
Non-muscle myosins in tumor progression, cancer cell invasion, and metastasis.
Nonmuscle Myosin II in cancer cell migration and mechanotransduction.
Opposing control of rhabdomyosarcoma growth and differentiation by myogenin and interleukin 4.
Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination.
Rho, ROCK and actomyosin contractility in metastasis as drug targets.
ROCK inhibition promotes microtentacles that enhance reattachment of breast cancer cells.
Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling.
Selective expression of myosin IC Isoform A in mouse and human cell lines and mouse prostate cancer tissues.
Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II.
Skeletal muscle rhabdomyosarcomas in inbred laboratory mice.
TGF-?1 Causes EMT by regulating N-Acetyl Glucosaminyl Transferases via Downregulation of Non Muscle Myosin II-A through JNK/P38/PI3K pathway in lung cancer.
The actin crosslinking protein palladin modulates force generation and mechanosensitivity of tumor associated fibroblasts.
The Bidirectional Regulation between MYL5 and HIF-1? Promotes Cervical Carcinoma Metastasis.
The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis.
The mechanical microenvironment regulates ovarian cancer cell morphology, migration, and spheroid disaggregation.
The Overexpression of NMHC IIA Promoted Invasion and Metastasis of Nasopharyngeal Carcinoma Cells.
TRIM59 deficiency curtails breast cancer metastasis through SQSTM1-selective autophagic degradation of PDCD10.
Upregulation of myosin Va by Snail is involved in cancer cell migration and metastasis.
Neoplasms
4-Hydroxyhexenal and 4-hydroxynonenal are mediators of the anti-cachectic effect of n-3 and n-6 polyunsaturated fatty acids on human lung cancer cells.
In vitro Mesothelial Clearance Assay that Models the Early Steps of Ovarian Cancer Metastasis.
?E-catenin is a candidate tumor suppressor for the development of E-cadherin-expressing lobular-type breast cancer.
A Chalcone from Ashitaba (Angelica keiskei) Stimulates Myoblast Differentiation and Inhibits Dexamethasone-Induced Muscle Atrophy.
A chemical biology screen reveals a role for Rab21-mediated control of actomyosin contractility in fibroblast-driven cancer invasion.
A comparative study of smooth muscle tumors utilizing light and electron microscopy, immunocytochemical staining and enzymatic assay.
A comparative study on the immunolocalization of keratin and myosin in salivary gland tumors.
A human homologue of the Drosophila tumour suppressor gene l(2)gl maps to 17p11.2-12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain.
A leucine-supplemented diet improved protein content of skeletal muscle in young tumor-bearing rats.
A novel role of myosin VI in human prostate cancer.
A Proteomic Study of Myosin II Motor Proteins during Tumor Cell Migration.
A serine-kinase associated with the p127-l(2)gl tumour suppressor of Drosophila may regulate the binding of p127 to nonmuscle myosin II heavy chain and the attachment of p127 to the plasma membrane.
A specific isoform of nonmuscle myosin II-C is required for cytokinesis in a tumor cell line.
A transcriptional cross-talk between RhoA and c-Myc inhibits the RhoA/Rock-dependent cytoskeleton.
A Zebrafish Model for a Human Myopathy Associated with Mutation of the Unconventional Myosin MYO18B.
Abnormal cytodifferentiation in leiomyosarcomas induced with injection of nickel subsulfide into skeletal muscles of rats. Light and electron microscopic observations.
Abnormal expression of leiomyoma cytoskeletal proteins involved in cell migration.
Actin expression in neural crest cell-derived tumors including schwannomas, malignant peripheral nerve sheath tumors, neurofibromas and melanocytic tumors.
Actin-like filaments in Ehrlich ascites tumor cells and their reaction with heavy meromyosin.
Activating Sphingosine-1-phospahte signaling in endothelial cells increases myosin light chain phosphorylation to decrease endothelial permeability thereby inhibiting cancer metastasis.
Activation of Myosin Phosphatase by Epigallocatechin-Gallate Sensitizes THP-1 Leukemic Cells to Daunorubicin.
Activation of RhoA,B,C by Yersinia Cytotoxic Necrotizing Factor (CNFy) induces apoptosis in LNCaP prostate cancer cells.
Active contractility at E-cadherin junctions and its implications for cell extrusion in cancer.
Actomyosin contractililty: force power drives tumor growth.
Actomyosin contractility confers mechanoprotection against TNF?-induced disruption of the intervertebral disc.
Actomyosin drives cancer cell nuclear dysmorphia and threatens genome stability.
Actomyosin tension as a determinant of metastatic cancer mechanical tropism.
Actomyosin-mediated cellular tension drives increased tissue stiffness and ?-catenin activation to induce epidermal hyperplasia and tumor growth.
Acuminolide A: structure and bioactivity of a new polyether macrolide from dinoflagellate Dinophysis acuminata.
Adenoid cystic carcinoma of the breast: prevalence, diagnostic criteria, and histogenesis.
Aggressive angiomyxoma of the vulva. Report of a case.
alpha-1-Antitrypsin, alpha-1-antichymotrypsin, actin, and myosin in uterine sarcomas.
ALPK1 phosphorylates myosin IIA modulating TNF-? trafficking in gout flares.
Alterations of membrane constituents in carcinomas and drug resistant tumour cells.
Altered expression of skeletal muscle myosin isoforms in cancer cachexia.
Alveolar rhabdomyosarcoma in a young female patient metastasizing to the brain.
Alveolar soft part sarcoma. An ultrastructural and immunocytochemical investigation of its histogenesis.
Alveolar soft-part sarcoma: evidence for its myogenic origin and for the involvement of 17q25.
Aminated Fullerene Abrogates Cancer Cell Migration by Directly Targeting Myosin Heavy Chain 9.
An autopsy case of malignant rhabdoid tumor arising from soft parts in the left inguinal region.
Apoptosis in the skeletal muscle of rats with heart failure is associated with increased serum levels of TNF-alpha and sphingosine.
Assessing Tumor Progression Factors by Somatic Gene Transfer into a Mouse Model: Bcl-xL Promotes Islet Tumor Cell Invasion.
Asymmetric mode of Ca²?-S100A4 interaction with nonmuscle myosin IIA generates nanomolar affinity required for filament remodeling.
Basal cells of H-Dunning tumor are myoepithelial cells. A comparative immunohistochemical and ultrastructural study with male accessory sex glands and mammary gland.
Basis for the isoform-specific interaction of myosin phosphatase subunits protein phosphatase 1c beta and myosin phosphatase targeting subunit 1.
Beneficial effects of dimethyl fumarate on experimental autoimmune myocarditis.
Bizarre leiomyoblastoma of the cervix uteri. Immunohistochemical and ultrastructural study.
Blebbistatin, a myosin inhibitor, is phototoxic to human cancer cells under exposure to blue light.
Brush border Myosin Ia has tumor suppressor activity in the intestine.
Brush border myosin Ia inactivation in gastric but not endometrial tumors.
Calcium control of actin-myosin-based contraction in Triton-treated murine bladder tumor cells.
Cancer Cachexia Induces Preferential Skeletal Muscle Myosin Loss When Combined With Denervation.
Cancer Cells Resist Mechanical Destruction in Circulation via RhoA/Actomyosin-Dependent Mechano-Adaptation.
Canine Spindle Cell Mammary Tumor: A Retrospective Study of 67 Cases.
Canopy Homolog 2 as a Novel Molecular Target in Hepatocarcinogenesis.
Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis.
Cardiac and skeletal myopathy in beta myosin heavy-chain simian virus 40 tsA58 transgenic mice.
Cardiac myocyte apoptosis provokes adverse cardiac remodeling in transgenic mice with targeted TNF overexpression.
Cardioprotective effects of early and late aerobic exercise training in experimental pulmonary arterial hypertension.
Catabolic response to stress and injury: implications for regulation.
CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis.
CD44v(3,8-10) is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells.
Cell scientist to watch - Victoria Sanz-Moreno.
Cell-Cell Adhesion and Cytoskeleton Tension Oppose Each Other in Regulating Tumor Cell Aggregation.
Central granular cell odontogenic tumour: report of the first malignant case and review of the literature.
Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase.
Chemotherapeutic resistance: a nano-mechanical point of view.
Chondrosarcoma with additional mesenchymal component (dedifferentiated chondrosarcoma). II. An immunohistochemical and electron microscopic study.
Chronic obstructive pulmonary disease: effects beyond the lungs.
Clear cell myomelanocytic tumor of the falciform ligament/ligamentum teres: a novel member of the perivascular epithelioid clear cell family of tumors with a predilection for children and young adults.
Clinical significance of myosin in colorectal cancer.
Clinicopathological Significance of NMIIA Overexpression in Human Gastric Cancer.
Cluster analysis of immunohistochemical markers in leiomyosarcoma delineates specific anatomic and gender subgroups.
Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.
Comparative phenotypes in rhabdomyosarcomas and developing skeletal muscle.
Comparative proteomic analysis of anti-benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-transformed and normal human bronchial epithelial G0/G1 cells.
Comparison of the efficiency of transgelin, smooth muscle myosin, and CD31 antibodies for the assessment of vascular tumor invasion and free tumor deposits in gastric, pancreatic, and colorectal adenocarcinomas.
Competition between human cells by entosis.
Competition between two high- and low-affinity protein-binding sites in myosin VI controls its cellular function.
Conditional Cardiac Overexpression of S100A6 Attenuates Myocyte Hypertrophy and Apoptosis Following Myocardial Infarction.
Contractile proteins in human cancer cells. Immunofluorescent and electron microscopic study.
Contribution of electron microscopy of cell cultures to the classification of three round cell sarcomas in children.
Correlation of S100A4 expression with invasion and metastasis in oral squamous cell carcinoma.
Coxsackievirus B3 induces T regulatory cells, which inhibit cardiomyopathy in tumor necrosis factor-alpha transgenic mice.
Crystal structure of the S100A4-nonmuscle myosin IIA tail fragment complex reveals an asymmetric target binding mechanism.
Cystic schwannoma of the pancreas.
Cytokines in juvenile dermatomyositis pathophysiology: potential and challenge.
Cytological findings of monophasic synovial sarcoma presenting as a lung mass: report of a case and review of the literature.
Cytoskeletal proteins regulate chromatin access of BR-C transcription factor and Rpd3-Sin3A histone deacetylase complex in Drosophila salivary glands.
Cytoskeleton and motility: an immunohistological and computer simulation analysis of melanocytic skin tumors.
Data on the negative regulation of invadopodia activity by MLCK.
Decreased expression of myosin light chain MYL9 in stroma predicts malignant progression and poor biochemical recurrence-free survival in prostate cancer.
Dedifferentiated leiomyosarcoma of the intestinal tract: histological, ultrastructural and immunohistochemical examinations.
Deficiency in myosin light-chain phosphorylation causes cytokinesis failure and multipolarity in cancer cells.
Degradation and Remodeling of Epitaxially Grown Collagen Fibrils.
Dependence of metastatic cancer cell invasion on MLCK-catalyzed phosphorylation of myosin regulatory light chain.
Different roles of a novel shrimp microRNA in white spot syndrome virus (WSSV) and Vibrio alginolyticus infection.
Differential Influence of IL-9 and IL-17 on Actin Cytoskeleton Regulates the Migration Potential of Human Keratinocytes.
Differential protein expression using proteomics from a crustacean brine shrimp (Artemia sinica) under CO2-driven seawater acidification.
Differentially expressed soluble proteins in aortic cells from atherosclerosis-susceptible and resistant pigeons.
Differentiation, proliferation and apoptosis levels in human leiomyoma and leiomyosarcoma.
Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas.
Direct inhibition of myosin II effectively blocks glioma invasion in the presence of multiple motogens.
Discriminating the earliest stages of mammary carcinoma using myoepithelial and proliferative markers.
Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110?/PIK3CA but not by HER2 or mutant AKT1.
Distinct roles of nonmuscle myosin II isoforms in the regulation of MDA-MB-231 breast cancer cell spreading and migration.
Distribution of myoepithelial cells and basement membrane proteins in the normal breast and in benign and malignant breast diseases.
Diverse matrix metalloproteinase functions regulate cancer amoeboid migration.
Downregulation of CPI-17 contributes to dysfunctional motility in chronic intestinal inflammation model mice and ulcerative colitis patients.
Drosophila nonmuscle myosin II promotes the asymmetric segregation of cell fate determinants by cortical exclusion rather than active transport.
DT-13 inhibits breast cancer cell migration via non-muscle myosin II-A regulation in tumor microenvironment synchronized adaptations.
Dual regulation of tumor necrosis factor-? on myosin light chain phosphorylation in vascular smooth muscle.
Effect of chronic excess of tumour necrosis factor-alpha on contractile proteins in rat skeletal muscle.
Effect of Ninjin'yoeito on the Loss of Skeletal Muscle Function in Cancer-Bearing Mice.
Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres.
Effects of chronic growth hormone hypersecretion on intrinsic contractility, energetics, isomyosin pattern, and myosin adenosine triphosphatase activity of rat left ventricle.
Effects of conditioned media from murine lung cancer cells and human tumor cells on cultured myotubes.
Effects of PAX3-FKHR on malignant phenotypes in alveolar rhabdomyosarcoma.
Effects of Ultra-high doserate FLASH Irradiation on the Tumor Microenvironment in Lewis Lung Carcinoma: Role of Myosin Light Chain.
Elevated expression of myosin X in tumours contributes to breast cancer aggressiveness and metastasis.
Embryonic form of smooth muscle myosin heavy chain (SMemb/MHC-B) in gastrointestinal stromal tumor and interstitial cells of Cajal.
Embryonic myosin heavy chain as a differentiation marker of developing human skeletal muscle and rhabdomyosarcoma. A monoclonal antibody study.
Endobronchial Smooth Muscle Tumors: A Series of Five Cases Highlighting Pitfalls in Diagnosis.
Endothelin-1 stimulates human colonic myofibroblast contraction and migration.
Enhancement of T cell localization in mammary tumors through transient inhibition of T cell myosin function.
Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation.
EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion.
Epidermal growth factor-mediated transient phosphorylation and membrane localization of myosin II-B are required for efficient chemotaxis.
Epithelial junctions maintain tissue architecture by directing planar spindle orientation.
Epstein-Barr Virus-Associated Smooth Muscle Tumors of Larynx: A Clinicopathologic Study and Comprehensive Literature Review of 12 Cases.
Evaluation of myosin VI, E-cadherin and beta-catenin immunostaining in renal cell carcinoma.
Evaluation of Parameters for Cancer-Induced Sarcopenia in Patients Autopsied after Death from Colorectal Cancer.
Expression of CCT6A mRNA in chicken granulosa cells is regulated by progesterone.
Expression of cytoskeletal components in melanocytic skin lesions. An immunohistochemical study.
Expression of embryonic-form smooth muscle myosin heavy chain in a gastrointestinal stromal tumor of the greater omentum.
Expression of muscle-specific actins and myosin in light microscopically undifferentiated small and dark cell malignancies of soft tissues.
Expression of myosin heavy chain isoforms in mammary epithelial cells and in myofibroblasts from different fibrotic settings during neoplasia.
Expression of the MyoD1 muscle determination gene defines differentiation capability but not tumorigenicity of human rhabdomyosarcomas.
Expression ratio of the TGF?-inducible gene MYO10 is prognostic for overall survival of squamous cell lung cancer patients and predicts chemotherapy response.
Extraskeletal Myxoid Chondrosarcoma of the Vulva With PLAG1 Gene Activation: Molecular Genetic Characterization of 2 Cases.
Fibronectin Modulates Cell Adhesion and Signaling to Promote Single Cell Migration of Highly Invasive Oral Squamous Cell Carcinoma.
Filamin B Enhances the Invasiveness of Cancer Cells into 3D Collagen Matrices.
Filopodia play an important role in the trans-mesothelial migration of ovarian cancer cells.
Fine needle aspiration biopsy diagnosis of rhabdomyosarcoma. An immunocytochemical study.
Fluorescence and electron microscopic study of intracellular F-actin in concanavalin A-treated and cytochalasin B-treated Ehrlich ascites tumor cells.
Food Shortage Causes Differential Effects on Body Composition and Tissue-Specific Gene Expression in Salmon Modified for Increased Growth Hormone Production.
Formoterol attenuates increased oxidative stress and myosin protein loss in respiratory and limb muscles of cancer cachectic rats.
Fourier-domain Jones-matrix mapping of a complex degree of mutual anisotropy in differentiation of biological tissues' pathological states.
From magnesium to magnesium transporters in cancer: TRPM7, a novel signature in tumour development.
Gastrointestinal stromal tumors and KIT-positive mesenchymal cells in the omentum.
GEF-H1 mediates tumor necrosis factor-alpha-induced Rho activation and myosin phosphorylation: role in the regulation of tubular paracellular permeability.
Generation of cells with phenotypes of both intercalated duct-type and myoepithelial cells in human parotid gland adenocarcinoma clonal cells grown in athymic nude mice.
Genome-wide association study and biological pathway analysis of the Eimeria maxima response in broilers.
Genomic Amplification and Functional Dependency of the Gamma Actin Gene ACTG1 in Uterine Cancer.
Genomic Sequencing of Cancer-related Genes in Sinonasal Squamous Cell Carcinoma and Coexisting Inverted Papilloma.
Glioma migration can be blocked by nontoxic inhibitors of myosin II.
Glomus tumor of the cheek: an immunohistochemical demonstration of actin and myosin.
Glomus tumor of the trachea. Immunohistochemical and electron microscopic studies.
Granular cell leiomyosarcoma of the skin.
Growth of tumor emboli within a vessel model reveals dependence on the magnitude of mechanical constraint.
Hepatitis B virus X protein disrupts stress fiber formation and triggers apoptosis.
Heterogeneous distribution of actin, myosin, fibronectin and basement membrane antigens in primary and metastatic human breast cancer.
Hierarchical cluster analysis of myoepithelial/basal cell markers in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma.
High-resolution traction force microscopy.
Histopathological and immunohistochemical studies on nickel sulfide-induced tumors in F344 rats.
HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growth.
How are the cellular functions of myosin VI regulated within the cell?
How myosin organization of the actin cytoskeleton contributes to the cancer phenotype.
HuR translocation to the cytoplasm of cancer cells in actin-independent manner.
Hyalinizing clear cell carcinoma: a case report and review of the literature.
Identification of myosin in human epithelial cancers with immunofluorescence.
Identification of squamous cell carcinoma associated proteins by proteomics and loss of beta tropomyosin expression in esophageal cancer.
Imaging of soft-tissue sarcomas with indium-111-labeled monoclonal antimyosin Fab fragments.
Immunocytochemical features of lens after cataract tissue--signalling molecules (growth factors, cytokines, other signalling molecules), cytoskeleton proteins, cellular and extracellular matrix proteins.
Immunohistochemical examination using the pericyte marker myosin 1B in a perivascular myoid tumor of soft tissue with definitive pericytic differentiation.
Immunohistochemical localization of keratin, vimentin and myosin in salivary gland tumors.
Immunohistochemical study of alveolar and embryonal rhabdomyosarcoma.
Immunohistochemical study of primary and recurrent basal cell and metatypical carcinomas of the skin.
Immunohistologic studies of tumors containing myosin.
Immunophenotype, ras oncogenes and p53 onco-suppressor gene in benzo(a)pyrene induced malignant soft tissue tumours in Wistar rats.
Immunoreactivity of paraffin-embedded normal tissues and mesenchymal tumors for smooth muscle myosin.
Imprint cytology of primary cardiac sarcomas: a report of 3 cases.
Increased cancer stem cell invasion is mediated by myosin IIB and nuclear translocation.
Increased expression of Nonmuscle Myosin IIs is associated with 3MC induced mouse tumor.
Induction of other differentiation stages in neoplastic epithelial duct and myoepithelial cells from the human salivary gland grown in athymic nude mice.
Induction of proteasome expression in skeletal muscle is attenuated by inhibitors of NF-kappaB activation.
Infantile digital fibromatosis. An electron microscopic and immunohistochemical study.
Inhibiting Tumor Fibrosis and Actomyosin through GPCR activation.
Inhibition of Myosin ATPase activity by halogenated pseudilins: a structure-activity study.
Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21(Cip1) expression and hampers tumour cell growth in vitro and in vivo.
Intermediate-sized filaments and specific markers in a human salivary gland adenocarcinoma cell line and its nude mouse tumors.
Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis.
Intramyocardial lipid accumulation in the failing human heart resembles the lipotoxic rat heart.
Intranodal hemorrhagic spindle-cell tumor with "amianthoid" fibers. Report of six cases of a distinctive mesenchymal neoplasm of the inguinal region that simulates Kaposi's sarcoma.
Intravascular glomus tumour: a previously undescribed phenomenon.
Intravital multiphoton imaging reveals multicellular streaming as a crucial component of in vivo cell migration in human breast tumors.
Inverse expression of S100A4 and E-cadherin is associated with metastatic potential in gastric cancer.
Isolation and characterization of clonal cell lines from a transplantable metastasizing rat mammary tumor, TR2CL.
JNK signaling contributes to skeletal muscle wasting and protein turnover in pancreatic cancer cachexia.
Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting.
Knockdown of Myosin 6 inhibits proliferation of oral squamous cell carcinoma cells.
Leiomyosarcoma of the skin with generalized metastases: electron microscopic and immunohistochemical study.
Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer.
Life without double-headed non-muscle myosin II motor proteins.
Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis-associated protein S100A4 (Mts1).
Lithium Chloride Protects against Sepsis-Induced Skeletal Muscle Atrophy and Cancer Cachexia.
LncRNA UCA1 promotes development of gastric cancer via the miR-145/MYO6 axis.
Localization of myosin XVA in endocrine tumors of gut and pancreas.
Localized Rho GTPase activation regulates RNA dynamics and compartmentalization in tumor cell protrusions.
Long non-coding RNA (LncRNA) MRPL23-AS1 promotes tumor progression and carcinogenesis in osteosarcoma by activating Wnt/?-catenin signaling via inhibiting microRNA miR-30b and upregulating myosin heavy chain 9 (MYH9).
Long noncoding RNA HAR1A regulates oral cancer progression through the alpha-kinase 1, bromodomain 7, and myosin IIA axis.
Long-term cigarette smoke exposure inhibits histone deacetylase 2 expression and enhances the nuclear factor-?B activation in skeletal muscle of mice.
Loss of E-Cadherin-Dependent Cell-Cell Adhesion and the Development and Progression of Cancer.
Loss of growth control and differentiation in the fu-1 variant of the L8 line of rat myoblasts.
Loss of MYO5B expression deregulates late endosome size which hinders mitotic spindle orientation.
Loss of myoepithelial cell characteristics in metastasizing rat mammary tumors relative to their nonmetastasizing counterparts.
Loss of Myosin Vb in colorectal cancer is a strong prognostic factor for disease recurrence.
Low-grade (fibromatosis-like) spindle cell carcinoma of the breast.
Macrophages promote matrix protrusive and invasive function of breast cancer cells via MIP-1? dependent upregulation of MYO3A gene in breast cancer cells.
Maternal hyperglycemia leads to fetal cardiac hyperplasia and dysfunction in a rat model.
Matrix rigidity differentially regulates invadopodia activity through ROCK1 and ROCK2.
Mechanics and Actomyosin-Dependent Survival/Chemoresistance of Suspended Tumor Cells in Shear Flow.
Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts.
Membrane-bound ICAM-1 contributes to the onset of proinvasive tumor stroma by controlling acto-myosin contractility in carcinoma-associated fibroblasts.
Menin, a tumor suppressor, associates with nonmuscle myosin II-A heavy chain.
Metastasis of a myxoid leiomyosarcoma via the renal and hepatic portal circulation in a sarus crane (Grus antigone).
Metastasis-associated protein S100A4: spotlight on its role in cell migration.
MicroRNA-200 family governs ovarian inclusion cyst formation and mode of ovarian cancer spread.
Minichromosome maintenance protein 7 regulates phagocytosis in kuruma shrimp Marsupenaeus japonicas against white spot syndrome virus.
Mismatch in mechanical and adhesive properties induces pulsating cancer cell migration in epithelial monolayer.
Modulating malignant epithelial tumor cell adhesion, migration and mechanics with nanorod surfaces.
Modulation of the cytoskeleton and intracellular calcium in leukocytes exhibiting a cancer-associated chemotaxis defect.
Molecular cloning of Kuruma shrimp Marsupenaeus japonicus endonuclease-reverse transcriptase and its positive role in white spot syndrome virus and Vibrio alginolyticus infection.
Molecular mechanisms underlying skeletal muscle weakness in human cancer: reduced myosin-actin cross-bridge formation and kinetics.
Motor protein function in skeletal abdominal muscle of cachectic cancer patients.
Multi-sample deformability cytometry of cancer cells.
Multifocal Histologically Malignant Epstein-Barr Virus-Associated Smooth Muscle Tumor in a Pediatric Transplant Patient With an Indolent Course.
Muscle paralysis and myosin loss in a patient with cancer cachexia.
Muscle wasting and dedifferentiation induced by oxidative stress in a murine model of cachexia is prevented by inhibitors of nitric oxide synthesis and antioxidants.
Muscle-specific gene expression in rhabdomyosarcomas and stages of human fetal skeletal muscle development.
MYBPH inhibits NM IIA assembly via direct interaction with NMHC IIA and reduces cell motility.
MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis.
MYH9 Regulates p53 Stability and Is a Tumor Suppressor in SCC.
MYH9 suppresses melanoma tumorigenesis, metastasis and regulates tumor microenvironment.
MYLK and MYL9 expression in non-small cell lung cancer identified by bioinformatics analysis of public expression data.
MYLK promotes hepatocellular carcinoma progression through regulating cytoskeleton to enhance epithelial-mesenchymal transition.
MYO18B interacts with the proteasomal subunit Sug1 and is degraded by the ubiquitin-proteasome pathway.
Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression.
Myocardial adaptive changes and damage in ischemic heart disease.
Myocardial Structural and Biological Anomalies Induced by High Fat Diet in Psammomys obesus Gerbils.
Myoepithelioma of soft tissue: A cytological-pathological correlation with literature review.
Myoepithelioma of the breast: histologic, immunologic, and electromicroscopic appearance.
Myofibroblastic tumor of soft tissue displaying desmin-positive and actin-negative immunophenotypes.
Myofibroblasts are responsible for the desmoplastic reaction surrounding human pancreatic carcinomas.
Myosin 10 Regulates Invasion, Mitosis, and Metabolic Signaling in Glioblastoma.
Myosin 1b promotes cell proliferation, migration, and invasion in cervical cancer.
Myosin 1C isoform A is a novel candidate diagnostic marker for prostate cancer.
Myosin 1e promotes breast cancer malignancy by enhancing tumor cell proliferation and stimulating tumor cell de-differentiation.
Myosin 5a regulates tumor migration and epithelial-mesenchymal transition in esophageal squamous cell carcinoma: utility as a prognostic factor.
Myosin and myoglobin as tumor markers in the diagnosis of rhabdomyosarcoma. A comparative study.
Myosin from pancreatic acinar carcinoma cells. Isolation, characterization and demonstration of heavy- and light-chain phosphorylation.
Myosin Heavy Chain 10 (MYH10) Gene Silencing Reduces Cell Migration and Invasion in the Glioma Cell Lines U251, T98G, and SHG44 by Inhibiting the Wnt/?-Catenin Pathway.
Myosin Heavy Chain 9: Oncogene or Tumor Suppressor Gene?
Myosin heavy chain degradation during apoptosis in endothelial cells.
Myosin heavy chain is not selectively decreased in murine cancer cachexia.
Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility.
Myosin II governs intracellular pressure and traction by distinct tropomyosin-dependent mechanisms.
Myosin II heavy chain isoforms are phosphorylated in an EGF-dependent manner: involvement of protein kinase C.
Myosin II in Cancer Cells Shapes the Immune Microenvironment.
Myosin II in mechanotransduction: master and commander of cell migration, morphogenesis, and cancer.
Myosin ii light chain phosphorylation regulates membrane localization and apoptotic signaling of tumor necrosis factor receptor-1.
Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion.
Myosin IIA suppresses glioblastoma development in a mechanically sensitive manner.
Myosin isoform expression in rat rhabdomyosarcoma induced by Moloney murine sarcoma virus.
Myosin phosphorylation on stress fibers predicts contact guidance behavior across diverse breast cancer cells.
Myosin regulation in the migration of tumor cells and leukocytes within a three-dimensional collagen matrix.
Myosin structure, allostery, and mechano-chemistry.
Myosin Va plays essential roles in maintaining normal mitosis, enhancing tumor cell motility and viability.
Myosin VI Contains a Compact Structural Motif that Binds to Ubiquitin Chains.
Myosin VI is a modulator of androgen-dependent gene expression.
Myosin VI is differentially regulated by DNA damage in p53- and cell type-dependent manners.
Myosin XVA expression in the pituitary and in other neuroendocrine tissues and tumors.
Myosins as fundamental components during tumorigenesis: diverse and indispensable.
Myosins: Domain Organisation, Motor Properties, Physiological Roles and Cellular Functions.
Neonatal myosin heavy chains are not expressed in Ni-induced rat rhabdomyosarcoma.
Neuroblastoma of parotid gland: report of a case and immunohistochemical characteristics.
Ni3S2-induced leiomyosarcomas in rabbit skeletal muscle: analysis of the tumoral myosin and its significance in the retrodifferentiation concept.
NMIIA promotes tumorigenesis and prevents chemosensitivity in colorectal cancer by activating AMPK/mTOR pathway.
Non-muscle myosin II is an independent predictor of overall survival for cystectomy candidates with early-stage bladder cancer.
Non-muscle myosin IIA differentially regulates intestinal epithelial cell restitution and matrix invasion.
Non-muscle myosin IIB is critical for nuclear translocation during 3D invasion.
Non-muscle myosins in tumor progression, cancer cell invasion, and metastasis.
Nonmuscle Myosin II in cancer cell migration and mechanotransduction.
Nonmuscle myosin IIA and IIB differentially modulate migration and alter gene expression in primary mouse tumorigenic cells.
Nonmuscle myosin IIA is associated with poor prognosis of esophageal squamous cancer.
Novel mechanism for negatively regulating Rho-kinase (ROCK) signaling through Coronin1B protein in neuregulin 1 (NRG-1)-induced tumor cell motility.
Novel SRF-ICA1L Fusions in Cellular Myoid Neoplasms With Potential For Malignant Behavior.
Opposing control of rhabdomyosarcoma growth and differentiation by myogenin and interleukin 4.
Orbital rhabdomyosarcoma: case report with immunohistochemical detection of muscle cell type intermediate filament proteins.
Ovarian cancer spheroids use myosin-generated force to clear the mesothelium.
Overexpression of myosin is associated with the development of uterine myoma.
Overexpression of Myosin Phosphatase Target Subunit 1 (MYPT1) Inhibits Tumor Progression and Metastasis of Gastric Cancer.
Overexpression of myosin VI in prostate cancer cells enhances PSA and VEGF secretion, but has no effect on endocytosis.
Paratesticular Rhabdomyoma: A Morphologically Distinct Sclerosing Variant.
Pathogenesis of early cardiac myocyte damage after severe burns.
Perineal rhabdomyosarcoma in a newborn child: pathological and biochemical studies with emphasis on contractile proteins.
Pharmacological activation of myosin II paralogs to correct cell mechanics defects.
Phenotypic characterization of perivascular myoid cell neoplasms, using myosin 1B, a newly identified human pericyte marker.
Pleomorphic and dedifferentiated leiomyosarcoma: clinicopathologic and immunohistochemical study of 41 cases.
Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics.
Podoplanin drives dedifferentiation and amoeboid invasion of melanoma.
Polyacrylamide gels for invadopodia and traction force assays on cancer cells.
Poorly differentiated desmin-negative and vimentin-positive leiomyosarcoma of the stomach examined by the immunohistochemical and quick-freezing and deep-etching methods.
Possible interrelationship between changes in F-actin and myosin II, protein phosphorylation, and cell volume regulation in Ehrlich ascites tumor cells.
Predicting the survival of patients with lung adenocarcinoma using a four-gene prognosis risk model.
Prevalence of Cytoplasmic Actin Mutations in Diffuse Large B-Cell Lymphoma and Multiple Myeloma: A Functional Assessment Based on Actin Three-Dimensional Structures.
Primary leiomyosarcoma of bone.
Primary leiomyosarcoma of bone. An immunohistochemical and ultrastructural study.
Primary leiomyosarcoma of the maxilla with regional lymph node metastasis. Report of a case and review of the literature.
Production of skeletal muscle elements by cell lines derived from neoplastic rat mammary epithelial stem cells.
Prostatic cystic epithelial-stromal tumors: a report of 2 new cases.
Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells.
Purification of myosin from Ehrlich ascites tumour cells (phosphorylation of its light chain and heavy chain).
Quantification of mutant versus wild-type myosin in human muscle biopsies using nano-LC/ESI-MS.
Quantitative Analysis of Myofibroblast Contraction by Traction Force Microscopy.
Radio-immunodetection of myosarcoma using 111indium antimyosin.
RASSF1C oncogene elicits amoeboid invasion, cancer stemness, and extracellular vesicle release via a SRC/Rho axis.
Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination.
Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin.
Recursive feedback between matrix dissipation and chemo-mechanical signaling drives oscillatory growth of cancer cell invadopodia.
Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment.
Regulation of heterogeneous cancer-associated fibroblasts: the molecular pathology of activated signaling pathways.
Regulation of transendothelial migration of colon cancer cells by E-selectin-mediated activation of p38 and ERK MAP kinases.
Release of nonmuscle myosin II from the cytosolic domain of tumor necrosis factor receptor 2 is required for target gene expression.
Renal myopericytoma: case report and review of literature.
Restored expression of the MYO18B gene suppresses orthotopic growth and the production of bloody pleural effusion by human malignant pleural mesothelioma cells in SCID mice.
Rhabdomyosarcomas in young pigs in a swine breeding farm: a morphologic and immunohistochemical study.
Rho-associated kinase inhibitor reduces tumor recurrence after liver transplantation in a rat hepatoma model.
ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma.
ROCK inhibition promotes microtentacles that enhance reattachment of breast cancer cells.
ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth.
ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo.
ROCK-driven actomyosin contractility induces tissue stiffness and tumor growth.
RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.
S100A4 is activated by RhoA and catalyzes the polymerization of non-muscle myosin, adhesion complex assembly and contraction in airway smooth muscle.
Sclerosing Spindle Cell Rhabdomyosarcoma in an Adult: Report of a New Case and Review of the Literature.
Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling.
Selective expression of myosin IC Isoform A in mouse and human cell lines and mouse prostate cancer tissues.
Shrinkage insensitivity of NKCC1 in myosin II-depleted cytoplasts from Ehrlich ascites tumor cells.
Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II.
Skeletal muscle differentiation in Wilms' tumor. Antibody identification and explant culture.
Skeletal muscle of gastric cancer patients expresses genes involved in muscle regeneration.
Skeletal muscle rhabdomyosarcomas in inbred laboratory mice.
Small GTP-binding protein Rho stimulates the actomyosin system, leading to invasion of tumor cells.
Smooth and skeletal muscle myosins in spindle cell tumors of soft tissue. An immunohistochemical study.
Smooth-muscle myosin mutations in hereditary non-polyposis colorectal cancer syndrome.
Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility.
So-called minute chemodectoma of the lung. An electron microscopic and immunohistochemical study.
Spatial compartmentalization of tumor necrosis factor (TNF) receptor 1-dependent signaling pathways in human airway smooth muscle cells. Lipid rafts are essential for TNF-alpha-mediated activation of RhoA but dispensable for the activation of the NF-kappaB and MAPK pathways.
Specific and reliable detection of Myosin 1C isoform A by RTqPCR in prostate cancer cells.
Spindle cell rhabdomyosarcoma in adults: clinicopathological and immunohistochemical analysis of seven new cases.
Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion.
Structural determinants governing S100A4-induced isoform-selective disassembly of non-muscle myosin II filaments.
Study and detection of potential markers for predicting metastasis into lymph nodes in prostate cancer.
Sulfiredoxin redox-sensitive interaction with S100A4 and non-muscle myosin IIA regulates cancer cell motility.
Targeting Actomyosin Contractility Suppresses Malignant Phenotypes of Acute Myeloid Leukemia Cells.
Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy.
Testicular Dysgenesis Syndrome and Long-Lasting Epigenetic Silencing of Mouse Sperm Genes Involved in the Reproductive System after Prenatal Exposure to DEHP.
TGF-?-Induced Transcription Sustains Amoeboid Melanoma Migration and Dissemination.
The actin cross-linker Filamin/Cheerio mediates tumor malignancy downstream of JNK signaling.
The actin crosslinking protein palladin modulates force generation and mechanosensitivity of tumor associated fibroblasts.
The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis.
The crustin-like peptide plays opposite role in shrimp immune response to Vibrio alginolyticus and white spot syndrome virus (WSSV) infection.
The cytoskeleton in cancer cells in animals and humans.
The Drosophila lethal(2)giant larvae tumor suppressor protein forms homo-oligomers and is associated with nonmuscle myosin II heavy chain.
The Evolution of Duplicated Genes of the Cpi-17/Phi-1 (ppp1r14) Family of Protein Phosphatase 1 Inhibitors in Teleosts.
The expression of MYH9 in osteosarcoma and its effect on the migration and invasion abilities of tumor cell.
The localization of cytoskeletal proteins and thyroglobulin in thyroid microcarcinoma in comparison with clinically manifested thyroid carcinoma.
The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells.
The microRNA profile of prostate carcinoma obtained by deep sequencing.
The NADPH oxidase NOX4 represses epithelial to amoeboid transition and efficient tumour dissemination.
The NMR-based characterization of the FTY720-SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET-PP2A interaction.
The Overexpression of NMHC IIA Promoted Invasion and Metastasis of Nasopharyngeal Carcinoma Cells.
The pathogenesis of postinfectious myocarditis.
The physical map of Mus musculus chromosome 11 reveals evolutionary relationships with different syntenic groups of genes in Homo sapiens.
The role of the cytoskeleton in migration and proliferation of a cultured human gastric cancer cell line using a new metastasis model.
The selective role of myosin VI in lymphoid leukemia cell migration.
The stressed cytoskeleton: How actin dynamics can shape stress-related consequences on synaptic plasticity and complex behavior.
The TRPM7 interactome defines a cytoskeletal complex linked to neuroblastoma progression.
The tumor suppressor capability of p53 is dependent on non-muscle myosin IIA function in head and neck cancer.
The tumor suppressor Lgl1 forms discrete complexes with NMII-A and Par6?-aPKC? that are affected by Lgl1 phosphorylation.
Tissue culture as a diagnostic technique for soft-tissue sarcoma of childhood.
TPA has no influence on the expression of myosin heavy chain isoforms in cultured adult cardiac muscle cells.
TPA-induced differentiation of human rhabdomyosarcoma cells: expression of the myogenic regulatory factors.
TRIM59 deficiency curtails breast cancer metastasis through SQSTM1-selective autophagic degradation of PDCD10.
TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation.
Tumor necrosis factor-alpha increases airway smooth muscle oxidants production through a NADPH oxidase-like system to enhance myosin light chain phosphorylation and contractility.
Tumor necrosis factor-alpha inhibits differentiation of myogenic cells in human urethral rhabdosphincter.
Tumor necrosis factor-alpha-induced activation of RhoA in airway smooth muscle cells: role in the Ca2+ sensitization of myosin light chain20 phosphorylation.
Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter.
Tumor stiffness is unrelated to myosin light chain phosphorylation in cancer cells.
Two forms of tumors in nude mice generated by a neoplastic rat mammary stem cell line.
UNC-45A Is Highly Expressed in the Proliferative Cells of the Mouse Genital Tract and in the Microtubule-Rich Areas of the Mouse Nervous System.
UNC-45A is preferentially expressed in epithelial cells and binds to and co-localizes with interphase MTs.
Unfractionated heparin attenuates endothelial barrier dysfunction via the phosphatidylinositol-3 kinase/serine/threonine kinase/nuclear factor kappa-B pathway.
Unique Cancer Migratory Behaviors in Confined Spaces of Microgroove Topography with Acute Wall Angles.
Unregulated smooth-muscle myosin in human intestinal neoplasia.
Upregulation of myosin Va by Snail is involved in cancer cell migration and metastasis.
Use of Histone Deacetylase 8 (HDAC8), a New Marker of Smooth Muscle Differentiation, in the Classification of Mesenchymal Tumors of the Uterus.
Ventilatory dysfunction in mdx mice: impact of tumor necrosis factor-alpha deletion.
Viable "Haemophilus somnus" induces myosin light-chain kinase-dependent decrease in brain endothelial cell monolayer resistance.
Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA.
Zebrafish Primordial Germ Cell Migration.
ZIP4 Promotes Muscle Wasting and Cachexia in Mice With Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer Cells.
[A case of multifocal inflammatory pseudotumor of the liver]
[A malignant mixed mesodermal tumor of the ovary]
[Actomyosin from a low-differentiation skeletal muscle tumor]
[Actomyosin preparations obtained from a skeletal muscle tumor of low differentiation using the traditional methods of muscle biochemistry]
[Angiomyoma of the retropharyngeal space]
[Diagnosis of leiomyosarcomas using an immunomorphological method]
[Embryonal rhabdomyosarcoma in the male reproductive system: A clinicopathological analysis].
[Immunoelectron microscopic and immunohistochemical study of adenoid cystic carcinoma of the salivary gland]
[Immunohistochemical localization of cytoskeletal proteins and thyroglobulin in thyroid micro cancers]
[Immunohistochemical research on human breast tumors using monoclonal antibodies to intermediate filament proteins. Cancer of the breast]
[Immunohistochemical studies on myosin in malignant tumors of childhood]
[Immunomorphological identification of myoepithelial cells in mixed tumors of the mammary gland in dogs]
[Immunomorphological method in the diagnosis of rhabdomyosarcomas]
[Isolation of actomyosin from a skeletal muscle tumor of low differentiation]
[Leiomyosarcoma metastatizing to the sphenoid bone presenting exophthalmos: a case report]
[Myosin and actin levels in poorly differentiated skeletal muscle tumors]
[Paratesticular rhabdomyosarcoma]
[Purification and biochemical characteristics of myosin from rat malignant sarcoma-45]
[Study of the modification of histidine residues, SH- and epsilon-NH2-groups of rat sarcoma-45 myosin by specific reagents]
[Suppression subtractive hybridization to identify differentially expressed gene between laryngeal tumor and the normal tissue adjacant to the tumor]
[The histogenesis of alveolar soft part sarcoma: a clinicopathological analysis of 135 cases]
[Types of myoepithelial cell proliferation in dyshormonal breast dysplasias and benign breast tumors]
Neoplastic Cells, Circulating
Cancer Cells Resist Mechanical Destruction in Circulation via RhoA/Actomyosin-Dependent Mechano-Adaptation.
Nephritis
Expression of a nonmuscle myosin heavy chain in glomerular cells differentiates various types of glomerular disease in rats.
Generation and characterization of mice with Myh9 deficiency.
Megakaryocyte and platelet abnormalities in a patient with a W33C mutation in the conserved SH3-like domain of myosin heavy chain IIA.
Nephrosclerosis
Expression of nonmuscle myosin heavy chain B (SMemb) in rat allogeneic kidney transplantation.
Nephrosis
Effect of a low-protein diet on expression of non-muscle type myosin heavy-chain isoforms in glomeruli of rats with puromycin aminonucleoside nephrosis.
Glomerular expression of smooth-muscle myosin heavy-chain isoforms in aminonucleoside nephrosis in rats.
Nephrosis, Lipoid
Mechanism Underlying Selective Albuminuria in Minimal Change Nephrotic Syndrome.
Nephrotic Syndrome
Mechanism Underlying Selective Albuminuria in Minimal Change Nephrotic Syndrome.
Podocyte expression of nonmuscle myosin heavy chain-IIA decreases in idiopathic nephrotic syndrome, especially in focal segmental glomerulosclerosis.
Nervous System Autoimmune Disease, Experimental
C-protein in the skeletal muscle induces severe autoimmune polymyositis in Lewis rats.
Experimental autoimmune myositis in SJL/J mice produced by immunization with syngeneic myosin B fraction. Transfer by both immunoglobulin G and T cells.
Inhibition of CX3CL1 (fractalkine) improves experimental autoimmune myositis in SJL/J mice.
Interleukin-37 (IL-37) Suppresses Pertussis Toxin-Induced Inflammatory Myopathy in a Rat Model.
Intravenous immunoglobulin prevents experimental autoimmune myositis in SJL mice by reducing anti-myosin antibody and by blocking complement deposition.
Myosin-induced autoimmune polymyositis in the rat.
Retinoid ameliorates experimental autoimmune myositis, with modulation of Th cell differentiation and antibody production in vivo.
Role of regulatory T cells in a new mouse model of experimental autoimmune myositis.
Skeletal muscle myosin is the autoantigen for experimental autoimmune myositis.
Nervous System Diseases
A role for myosin Va in cerebellar plasticity and motor learning: a possible mechanism underlying neurological disorder in myosin Va disease.
Conventional and Non-Conventional Roles of Non-Muscle Myosin II-Actin in Neuronal Development and Degeneration.
Neural Tube Defects
Folic acid modifies the shape of epithelial cells during morphogenesis via a Folr1 and MLCK dependent mechanism.
Neurilemmoma
Cystic schwannoma of the pancreas.
Neuroblastoma
A unique cellular myosin II exhibiting differential expression in the cerebral cortex.
Actin and myosin synthesis during differentiation of neuroblastoma cells.
Actin detected in mouse neuroblastoma cells by binding of heavy meromyosin.
Immunofluorescence demonstrates the distribution of actin, myosin and intermediate filaments in cultured neuroblastoma cells.
Immunohistochemical study of alveolar and embryonal rhabdomyosarcoma.
Isolation and characterization of myosin from cloned rat glioma and mouse neuroblastoma cells.
MiRNA-335 Suppresses Neuroblastoma Cell Invasiveness By Direct Targeting of Multiple Genes from the non-Canonical TGF-? Signalling Pathway.
Myosin II distribution in neurons is consistent with a role in growth cone motility but not synaptic vesicle mobilization.
Myosin IIA drives neurite retraction.
Neuroblastoma cell lines showing smooth muscle cell phenotypes.
Separate but linked functions of conventional myosins modulate adhesion and neurite outgrowth.
The localization of actin-like fibers in cultured neuroblastoma cells as revealed by heavy meromyosin binding.
[Smooth muscle myosin of SM1 and SM2 isoforms expressing human neuroblastoma cell line of MP-N-MS]
Neurodegenerative Diseases
Myosin structure, allostery, and mechano-chemistry.
Nonmuscle myosin IIB regulates Parkin-mediated mitophagy associated with amyotrophic lateral sclerosis-linked TDP-43.
Neurofibrosarcoma
[A case of multifocal inflammatory pseudotumor of the liver]
Neuroleptic Malignant Syndrome
[Significance of serum myosin light chain-1 level in neuroleptic malignant syndrome]
Neurologic Manifestations
Myosin Va controls oligodendrocyte morphogenesis and myelination.
Neuroma
An aligned nanofiber nerve conduit that inhibits painful traumatic neuroma formation through regulation of the RhoA/ROCK signaling pathway.
Neuromuscular Diseases
A new de novo missense mutation in MYH2 expands clinical and genetic findings in hereditary myosin myopathies.
Analysis of muscle proteins in acute quadriplegic myopathy.
Increased serum myosin light chain 3 level in neuromuscular diseases.
Modulation of Agrin and RhoA Pathways Ameliorates Movement Defects and Synapse Morphology in MYO9A-Depleted Zebrafish.
Specific isomyosin proportions in hyperexcitable and physiologically denervated mouse muscle.
[Significance of serum myosin light chain-1 level in neuroleptic malignant syndrome]
Nevus
Expression of cytoskeletal components in melanocytic skin lesions. An immunohistochemical study.
Non-alcoholic Fatty Liver Disease
Genome-Wide Association Study of Lean Nonalcoholic Fatty Liver Disease Suggests Human Leukocyte Antigen as a Novel Candidate Locus.
non-specific serine/threonine protein kinase deficiency
ROCK1 Deficiency Enhances Protective Effects of Antioxidants against Apoptosis and Cell Detachment.
Obesity
Cardiac contractile dysfunction in Lep/Lep obesity is accompanied by NADPH oxidase activation, oxidative modification of sarco(endo)plasmic reticulum Ca2+-ATPase and myosin heavy chain isozyme switch.
Contractility of permeabilized rat vastus intermedius muscle fibres following high-fat, high-sucrose diet consumption.
Effects of aging and obesity on respiratory muscle phenotype in Zucker rats.
Muscle-Specific Myosin Heavy Chain Shifts in Response to a Long-Term High Fat/High Sugar Diet and Resveratrol Treatment in Nonhuman Primates.
Obesity and aging affects skeletal muscle renin-angiotensin system and myosin heavy chain proportions in pre-diabetic Zucker rats.
Obstetric Labor, Premature
Pharmacologic levels of nitrendipine do not affect actin-myosin interaction in the human uterus and placenta.
Open Bite
Fiber-type differences in masseter muscle associated with different facial morphologies.
Ophthalmoplegia
A novel MYH2 mutation in family members presenting with congenital myopathy, ophthalmoplegia and facial weakness.
Hereditary inclusion-body myopathies.
Myosin myopathy with external ophthalmoplegia associated with a novel homozygous mutation in MYH2.
Recessive myosin myopathy with external ophthalmoplegia associated with MYH2 mutations.
Opisthorchiasis
[Organ pathology in chronic tissue-dwelling helminthic infections: role of blood and tissue eosinophilia, immunoglobulinemia E, G4, and immune response-inducing factors]
Optic Atrophy, Hereditary, Leber
Hereditary Retinal Dystrophy.
Optic Nerve Diseases
Deletion of myosin VI causes slow retinal optic neuropathy and age-related macular degeneration (AMD)-relevant retinal phenotype.
Hereditary Retinal Dystrophy.
Osteoarthritis
Characteristics of the gluteus medius muscle in an asymptomatic patient with radiographic signs of coxarthrosis.
Muscular changes in osteoarthritis of the hip and knee.
Osteoarthritis, Hip
Muscular changes in osteoarthritis of the hip and knee.
Osteoarthritis, Knee
Muscular changes in osteoarthritis of the hip and knee.
Osteolysis
Differential messenger ribonucleic acid expression in aggressive versus linear periprosthetic osteolysis.
Osteoporosis
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Protein metabolism in alcoholism: effects on specific tissues and the whole body.
[Basic results of an experiment with mammals on the Kosmos-782 biosatellite]
Osteosarcoma
Actomyosin, vimentin and LINC complex pull on osteosarcoma nuclei to deform on micropillar topography.
Evaluation of serum osteocalcin and myosin in pediatric patients affected by osteosarcoma and rhabdomyosarcoma.
Identification of potential biomarkers and therapeutic targets for human IgA nephropathy and hypertensive nephropathy by bioinformatics analysis.
Long non-coding RNA (LncRNA) MRPL23-AS1 promotes tumor progression and carcinogenesis in osteosarcoma by activating Wnt/?-catenin signaling via inhibiting microRNA miR-30b and upregulating myosin heavy chain 9 (MYH9).
Mechanosensitive myosin II but not cofilin primarily contributes to cyclic cell stretch-induced selective disassembly of actin stress fibers.
Myosin-18B Promotes the Assembly of Myosin II Stacks for Maturation of Contractile Actomyosin Bundles.
Osteosarcoma cells in tissue culture. III. Actin filament distribution.
The expression of MYH9 in osteosarcoma and its effect on the migration and invasion abilities of tumor cell.
What factors determine the number of nonmuscle myosin II in the sarcomeric unit of stress fibers?
Ototoxicity
Myosin VIIa and otoferlin in cochlear inner hair cells have distinct response to ototoxic exposure.
Myosin VIIA is required for aminoglycoside accumulation in cochlear hair cells.
Ovarian Neoplasms
Akt2/ZEB2 may be a biomarker for exfoliant cells in ascitic fluid in advanced grades of serous ovarian carcinoma.
Alendronate inhibits lysophosphatidic acid-induced migration of human ovarian cancer cells by attenuating the activation of rho.
Diverse functions of myosin VI elucidated by an isoform-specific ?-helix domain.
Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer.
Lysophosphatidic acid induces focal adhesion assembly through Rho/Rho-associated kinase pathway in human ovarian cancer cells.
MicroRNA-200 family governs ovarian inclusion cyst formation and mode of ovarian cancer spread.
Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility.
Ovarian cancer spheroids use myosin-generated force to clear the mesothelium.
Soft drug-resistant ovarian cancer cells migrate via two distinct mechanisms utilizing myosin II-based contractility.
The temporal and spatial expression pattern of Myosin Va, Vb and VI in the mouse ovary.
UNC-45A Is Highly Expressed in the Proliferative Cells of the Mouse Genital Tract and in the Microtubule-Rich Areas of the Mouse Nervous System.
Pancreatic Neoplasms
Differential Contributions of Actin and Myosin to the Physical Phenotypes and Invasion of Pancreatic Cancer Cells.
ROCK signalling induced gene expression changes in mouse pancreatic ductal adenocarcinoma cells.
Targeting Mechanoresponsive Proteins in Pancreatic Cancer: 4-Hydroxyacetophenone Blocks Dissemination and Invasion by Activating MYH14.
Pancreaticobiliary Maljunction
Higher expression of phosphorylated myosin regulatory light chain in the common bile duct in pancreaticobiliary maljunction accompanied by bile duct dilatation in children: a post-mortem observational study.
Pancreatitis
Association analysis of genetic variants in the myosin IXB gene in acute pancreatitis.
Papilloma
New trends of immunohistochemistry for making differential diagnosis of breast lesions.
Papilloma, Intraductal
Diagnostic utility of p75 neurotrophin receptor (p75NTR) as a marker of breast myoepithelial cells.
Intracystic papillary carcinomas of the breast: a reevaluation using a panel of myoepithelial cell markers.
Myoepithelial cell staining patterns of papillary breast lesions: from intraductal papillomas to invasive papillary carcinomas.
Paralysis
Botulinum toxin-induced paralysis leads to slower myosin heavy chain isoform composition and reduced titin content in juvenile rat gastrocnemius muscle.
Long-term changes in myosin heavy chain composition after botulinum toxin a injection into rat medial rectus muscle.
Muscle paralysis and myosin loss in a patient with cancer cachexia.
Mutations in MYLPF Cause a Novel Segmental Amyoplasia that Manifests as Distal Arthrogryposis.
Myofibrillar myopathy caused by a mutation in the motor domain of mouse MyHC IIb.
Myosin heavy chain isoform mRNA and protein levels after long-term paralysis.
Myosin heavy chains in fibers of TTX-paralyzed rat soleus and medial gastrocnemius muscles.
Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: Underlying mechanisms.
Regulation of myosin heavy chain expression in adult rat hindlimb muscles during short-term paralysis: comparison of denervation and tetrodotoxin-induced neural inactivation.
The fraction of strongly bound cross-bridges is increased in mice that carry the myopathy-linked myosin heavy chain mutation MYH4L342Q.
The myosin co-chaperone UNC-45 is required for skeletal and cardiac muscle function in zebrafish.
The UNC-45 chaperone mediates sarcomere assembly through myosin degradation in Caenorhabditis elegans.
Thixotropy of levator palpebrae as the cause of lagophthalmos after peripheral facial nerve palsy.
Parasitemia
Induction of high levels of IgG autoantibodies in mice infected with Plasmodium chabaudi.
Parasite control and skeletal myositis in Trypanosoma cruzi-infected and exercised rats.
Parasitic Diseases
Role of cytokines in autoimmune myocarditis and cardiomyopathy.
Paresis
Decreased capillarization and a shift to fast myosin heavy chain IIx in the biceps brachii muscle from young adults with spastic paresis.
[The Development of Clinical and Morphological Manifestations of Chronic Alcoholic Myopathy in Men with Prolonged Alcohol Intoxication].
Pericarditis
Myosin autoantibodies detected by immunofluorescence.
Peripheral Arterial Disease
Resistance training in patients with peripheral arterial disease: effects on myosin isoforms, fiber type distribution, and capillary supply to skeletal muscle.
Peripheral Nervous System Diseases
Effect of endurance exercise on myosin heavy chain isoform expression in diabetic rats with peripheral neuropathy.
Myosin heavy chain isoform immunolabelling in diabetic rats with peripheral neuropathy.
The R941L mutation in MYH14 disrupts mitochondrial fission and associates with peripheral neuropathy.
Pharyngitis
Comprehensive analysis of antibody responses to streptococcal and tissue antigens in patients with acute rheumatic fever.
Elevated levels of IgG specific antimyosin antibodies in acute rheumatic fever (ARF): differential profiles of antibodies to myosin and soluble myocardial antigens in ARF, acute glomerulonephritis and group A streptococcal pharyngitis.
Reactivity of rheumatic fever and scarlet fever patients' sera with group A streptococcal M protein, cardiac myosin, and cardiac tropomyosin: a retrospective study.
Pheochromocytoma
Myosin and myosin phosphorylation in pheochromocytoma (PC12) cells.
Piebaldism
Analysis of the interactions between Rab GTPases and class V myosins.
Pituitary Neoplasms
Localization of myosin XVA in endocrine tumors of gut and pancreas.
Myosin XVA expression in the pituitary and in other neuroendocrine tissues and tumors.
Placental Insufficiency
[Expression of contractile proteins alpha-actin and myosin of smooth muscle cells and collagen of IV type in human placenta at placental insufficiency in III trimester of pregnancy]
Plasmacytoma
Levels of corticotropin releasing factor-like immunoreactivity in mammalian hypothalamic and extrahypothalamic brain tissue as determined with a monoclonal antibody to the ovine material.
Restricted immunoglobulin variable region (Ig V) gene expression accompanies secondary rearrangements of light chain Ig V genes in mouse plasmacytomas.
Pleural Effusion
Expression of ERCC1, TYMS, RRM1, TUBB3, non-muscle myosin II, myoglobin and MyoD1 in lung adenocarcinoma pleural effusions predicts survival in patients receiving platinum-based chemotherapy.
Pneumonia
LPS-induced lung inflammation is linked to increased epithelial permeability: role of MLCK.
VDR attenuates acute lung injury by blocking Ang-2-Tie-2 pathway and renin-angiotensin system.
Pneumonia, Aspiration
Congenital myopathy due to myosin heavy chain 2 mutation presenting as chronic aspiration pneumonia in infancy.
Polyarteritis Nodosa
Recurrent juvenile dermatomyositis and cutaneous necrotizing arteritis with molecular mimicry between streptococcal type 5 M protein and human skeletal myosin.
Polycystic Kidney Diseases
High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping.
Polycystic Kidney, Autosomal Dominant
Role of the polycystins as mechanosensors of extracellular stiffness.
Polymyositis
Adhesion molecule expression in experimental myositis.
C-protein in the skeletal muscle induces severe autoimmune polymyositis in Lewis rats.
Cardiac troponin and beta-type myosin heavy chain concentrations in patients with polymyositis or dermatomyositis.
Human muscle proteins: analysis by two-dimensional electrophoresis.
Myosin light chains and muscle pathology.
New application of myocardial antimyosin scintigraphy: diagnosis of myocardial disease in polymyositis.
Radioimmunoassay for antibodies to human skeletal muscle myosin in serum from patients with polymyositis.
Role of regulatory T cells in a new mouse model of experimental autoimmune myositis.
Polyneuropathies
Myogenesis in human denervated muscle biopsies.
Prader-Willi Syndrome
A Novel Mutation in the Myosin Binding Protein C Gene in a Prader-Willi Syndrome Pedigree.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Myosin-IIA regulates leukemia engraftment and brain infiltration in a mouse model of acute lymphoblastic leukemia.
The purification and quantitation of myosin from cultured cells.
Prediabetic State
Diastolic dysfunction is initiated by cardiomyocyte impairment ahead of endothelial dysfunction due to increased oxidative stress and inflammation in an experimental prediabetes model.
Pregnancy, Ectopic
Serum levels of myoglobin, creatine phosphokinase, and smooth muscle heavy-chain myosin in patients with ectopic pregnancy.
Serum levels of smooth muscle heavy-chain myosin in patients with ectopic pregnancy.
Pregnancy, Prolonged
[Accumulation of actomyosin and its adenosine triphosphatase activity in the muscle of cervix uteri in prolonged pregnancy]
Progeria
Decreased vascular smooth muscle contractility in Hutchinson-Gilford Progeria Syndrome linked to defective smooth muscle myosin heavy chain expression.
Prognathism
Genetic variation in myosin 1H contributes to mandibular prognathism.
Relationship of the rs10850110 and rs11611277 polymorphisms of the MYO1H gene with non-syndromic mandibular prognathism in the Iranian population.
Prostatic Hyperplasia
Alpha-blockade downregulates myosin heavy chain gene expression in human benign prostatic hyperplasia.
Morphological analogies of fetal prostate stroma and stromal nodules in BPH.
Prostatic Intraepithelial Neoplasia
Selective expression of myosin IC Isoform A in mouse and human cell lines and mouse prostate cancer tissues.
Prostatic Neoplasms
A novel role of myosin VI in human prostate cancer.
Capping protein regulator and myosin 1 linker 3 regulates transcription of key cytokines in activated phagocytic cells.
Decreased expression of myosin light chain MYL9 in stroma predicts malignant progression and poor biochemical recurrence-free survival in prostate cancer.
GOLPH2 and MYO6: putative prostate cancer markers localized to the Golgi apparatus.
High-speed broadband monitoring of cell viscoelasticity in real time shows myosin-dependent oscillations.
Identification of novel ROCK inhibitors with anti-migratory and anti-invasive activities.
Knockdown of myosin VI by lentivirus-mediated short hairpin RNA suppresses proliferation of melanoma.
Multi-sample deformability cytometry of cancer cells.
Myosin 1b promotes cell proliferation, migration, and invasion in cervical cancer.
Myosin 1C isoform A is a novel candidate diagnostic marker for prostate cancer.
Myosin isoform expressed in metastatic prostate cancer stimulates cell invasion.
Myosin superfamily: The multi-functional and irreplaceable factors in spermatogenesis and testicular tumors.
Myosin Va plays essential roles in maintaining normal mitosis, enhancing tumor cell motility and viability.
Myosin VI is a modulator of androgen-dependent gene expression.
NDP52 activates nuclear myosin VI to enhance RNA polymerase II transcription.
Overexpression of myosin VI in prostate cancer cells enhances PSA and VEGF secretion, but has no effect on endocytosis.
PAK1 regulates myosin II-B phosphorylation, filament assembly, localization and cell chemotaxis.
Selective expression of myosin IC Isoform A in mouse and human cell lines and mouse prostate cancer tissues.
Specific and reliable detection of Myosin 1C isoform A by RTqPCR in prostate cancer cells.
Specific Myosins Control Actin Organization, Cell Morphology, and Migration in Prostate Cancer Cells.
The microRNA profile of prostate carcinoma obtained by deep sequencing.
Protein Deficiency
The genetic basis of pediatric cardiovascular disease.
protein-serine/threonine phosphatase deficiency
Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy.
Proteinuria
Modulation of cytoskeletal organization of podocytes during the course of aminonucleoside nephrosis in rats.
Pterygium
Activation of the Sphingosine 1 Phosphate-Rho Pathway in Pterygium and in Ultraviolet-Irradiated Normal Conjunctiva.
Pulmonary Arterial Hypertension
Preventive training does not interfere with mRNA-encoding myosin and collagen expression during pulmonary arterial hypertension.
Pulmonary Disease, Chronic Obstructive
Activation of the ubiquitin-proteasome pathway in the diaphragm in chronic obstructive pulmonary disease.
Altered expression of myosin heavy chain in the vastus lateralis muscle in patients with COPD.
Developmental myosin heavy chains in the adult human diaphragm: coexpression patterns and effect of COPD.
Diaphragm dysfunction in chronic obstructive pulmonary disease.
Does oxidative stress modulate limb muscle atrophy in severe copd patients?
Effect of chronic obstructive pulmonary disease on calcium pump ATPase expression in human diaphragm.
Effects and mechanism of bufei yishen formula in a rat chronic obstructive pulmonary disease model.
Fibre types in skeletal muscles of chronic obstructive pulmonary disease patients related to respiratory function and exercise tolerance.
Myosin heavy chain gene expression changes in the diaphragm of patients with chronic lung hyperinflation.
Oxidized proteins and superoxide anion production in the diaphragm of severe COPD patients.
Parasternal intercostal muscle remodeling in severe chronic obstructive pulmonary disease.
Physiological properties of human diaphragm muscle fibres and the effect of chronic obstructive pulmonary disease.
Restrictions in ATP diffusion within sarcomeres can provoke ATP-depleted zones impairing exercise capacity in chronic obstructive pulmonary disease.
The phosphodiesterase-4 inhibitor roflumilast reverts proteolysis in skeletal muscle cells of patients with COPD cachexia.
Pulmonary Edema
VDR attenuates acute lung injury by blocking Ang-2-Tie-2 pathway and renin-angiotensin system.
[Protective effect of myosin light-chain kinase inhibitor on acute lung injury.]
Pulmonary Embolism
Plasma skeletal muscle myosin phenotypes identified by immunoblotting are associated with pulmonary embolism occurrence in young adults.
Pulmonary Valve Stenosis
Alterations of subunit composition and ATPase activity of myosin in early hypertrophied right ventricles of dogs with mild experimental pulmonic stenosis.
Differential responses of canine myosin ATPase activity and tissue gases in the pressure-overloaded ventricle dependent upon degree of obstruction: mild versus severe pulmonic and aortic stenosis.
Modulation of myosin in right ventricular hypertrophy.
Regulation of human heart contractility by essential myosin light chain isoforms.
Quadriplegia
Acute quadriplegia and loss of muscle myosin in patients treated with nondepolarizing neuromuscular blocking agents and corticosteroids: mechanisms at the cellular and molecular levels.
Neurogenic vs. Myogenic Origin of Acquired Muscle Paralysis in Intensive Care Unit (ICU) Patients: Evaluation of Different Diagnostic Methods.
Renal Insufficiency
Anesthetic Management of Living-Donor Renal Transplantation in a Patient With Epstein Syndrome Using Rotational Thromboelastometry: A Case Report.
Correlation between the clinical phenotype of MYH9-related disease and tissue distribution of class II nonmuscle myosin heavy chains.
Inhibition of Smooth Muscle Myosin as a Novel Therapeutic Target for Hypertension.
[Increased serum levels of human cardiac myosin light chain 1 in patients with renal failure]
Renal Insufficiency, Chronic
Association between polymorphism rs2032487 in the non-muscle myosin heavy chain IIA gene (MHY9) and chronic kidney disease secondary to type 2 diabetes mellitus in a population of the Canary Islands.
Association of MYH9 Polymorphisms with Hypertension in Patients with Chronic Kidney Disease in China.
CKD in MYH9-related disorders.
Polymorphisms in the non-muscle myosin heavy chain gene (MYH9) are associated with lower glomerular filtration rate in mixed ancestry diabetic subjects from South Africa.
Reperfusion Injury
Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury.
Cardiac myosin binding protein-C: a potential early-stage, cardiac-specific biomarker of ischemia-reperfusion injury.
Complement receptor 2, natural antibodies and innate immunity: Inter-relationships in B cell selection and activation.
Degradation of myosin light chain in isolated rat hearts subjected to ischemia-reperfusion injury: a new intracellular target for matrix metalloproteinase-2.
Endothelial Conditional Knockdown of NMMHC IIA (Nonmuscle Myosin Heavy Chain IIA) Attenuates Blood-Brain Barrier Damage During Ischemia-Reperfusion Injury.
Evaluation of the protective effect of verapamil on reperfusion injury by 111In anticardiac myosin antibody in canine myocardial infarction.
Maladaptive Modulations of NLRP3 Inflammasome and Cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial Ischemia/Reperfusion Injury in Mice.
Reperfusion injury to skeletal muscle affects primarily type II muscle fibers.
Viral myocarditis in children.
Respiratory Insufficiency
Acute myopathy with selective degeneration of myosin filaments following status asthmaticus treated with methylprednisolone and vecuronium.
Retinal Degeneration
A class III myosin expressed in the retina is a potential candidate for Bardet-Biedl syndrome.
Distinct roles of the Drosophila ninaC kinase and myosin domains revealed by systematic mutagenesis.
Phenotype of DFNA11: a nonsyndromic hearing loss caused by a myosin VIIA mutation.
The cloning and developmental expression of unconventional myosin IXA (MYO9A) a gene in the Bardet-Biedl syndrome (BBS4) region at chromosome 15q22-q23.
Retinal Diseases
A class III myosin expressed in the retina is a potential candidate for Bardet-Biedl syndrome.
New insights into the regulation of myosin light chain phosphorylation in retinal pigment epithelial cells.
Retinitis Pigmentosa
A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth.
Analysis of DNA elements that modulate myosin VIIA expression in humans.
Electroretinographic anomalies in mice with mutations in Myo7a, the gene involved in human Usher syndrome type 1B.
Erratum: analysis of DNA elements that modulate myosin VIIa expression in humans.
Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B.
Expression of myosin VIIA during mouse embryogenesis.
Hereditary Retinal Dystrophy.
Human myosin VIIA responsible for the Usher 1B syndrome: a predicted membrane-associated motor protein expressed in developing sensory epithelia.
Isobaric Tags for Relative and Absolute Quantitation-Based Proteomic Analysis of Patent and Constricted Ductus Arteriosus Tissues Confirms the Systemic Regulation of Ductus Arteriosus Closure.
myosin 7aa(-/-) mutant zebrafish show mild photoreceptor degeneration and reduced electroretinographic responses.
Retinoblastoma
Activation of Myosin Phosphatase by Epigallocatechin-Gallate Sensitizes THP-1 Leukemic Cells to Daunorubicin.
Exploiting dinucleotide microsatellites conserved among mammalian species.
Expression of late myogenic differentiation markers in sarcoplasmic masses of patients with myotonic dystrophy.
Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development.
KAP regulates ROCK2 and Cdk2 in an RNA-activated glioblastoma invasion pathway.
Sequence-specific binding of recombinant Zbed4 to DNA: insights into Zbed4 participation in gene transcription and its association with other proteins.
Sprouty-2 overexpression in C2C12 cells confers myogenic differentiation properties in the presence of FGF2.
Retinoschisis
Hereditary Retinal Dystrophy.
Retrognathia
Relationship of the rs10850110 and rs11611277 polymorphisms of the MYO1H gene with non-syndromic mandibular prognathism in the Iranian population.
Role of myosin 1H gene polymorphisms in mandibular retrognathism.
Rhabdomyolysis
Myosin heavy-chain fragments and cardiac troponins in the serum in rhabdomyolysis. Diagnostic specificity of new biochemical markers.
N-Methyl-3,4-methylendioxymethamphetamine (MDMA)-related coagulopathy and rhabdomyolysis: A case series and literature review.
Prevalence of the E321G MYH1 variant for immune-mediated myositis and nonexertional rhabdomyolysis in performance subgroups of American Quarter Horses.
The psychoactive drug 25B-NBOMe recapitulates rhabdomyolysis in zebrafish larvae.
Rhabdomyoma
Extracardiac rhabdomyoma: An immunocytochemical study and review of the literature.
Unexpected infant death attributable to cardiac tumor or cardiomyopathy. Immunohistochemical and electron microscopical findings in three cases.
Rhabdomyosarcoma
Alveolar rhabdomyosarcoma in a young female patient metastasizing to the brain.
Antimyosin and antirhabdomyoblast sera: their use for the diagnosis of childhood rhabdomyosarcoma.
Bone marrow metastases in disseminated alveolar rhabdomyosarcoma: case report with ultrastructural study and review.
Cadherin-11 is highly expressed in rhabdomyosarcomas and during differentiation of myoblasts in vitro.
Embryonic myosin heavy chain as a differentiation marker of developing human skeletal muscle and rhabdomyosarcoma. A monoclonal antibody study.
Evaluation of serum osteocalcin and myosin in pediatric patients affected by osteosarcoma and rhabdomyosarcoma.
Expression of developmentally regulated muscle proteins in rhabdomyosarcomas.
Expression of the MyoD1 muscle determination gene defines differentiation capability but not tumorigenicity of human rhabdomyosarcomas.
Fetal heavy chain skeletal myosin. An oncofetal antigen expressed by rhabdomyosarcoma.
Fine needle aspiration biopsy diagnosis of rhabdomyosarcoma. An immunocytochemical study.
Histopathological and immunohistochemical studies on nickel sulfide-induced tumors in F344 rats.
Identification of new genes related to the myogenic differentiation arrest of human rhabdomyosarcoma cells.
Immunohistochemical detection of myogenin and p21 in methylcholanthrene-induced mouse rhabdomyosarcomas.
Immunohistochemical evaluation of chemically induced rhabdomyosarcomas in rats: diagnostic utility of MyoD1.
Immunohistochemical studies of rhabdomyosarcoma.
In vitro differentiation of rhabdomyosarcomas induced by nickel or by Moloney murine sarcoma virus.
Indium 111 antimyosin for the detection of leiomyosarcoma and rhabdomyosarcoma.
Myosin and myoglobin as tumor markers in the diagnosis of rhabdomyosarcoma. A comparative study.
Myosin isoform expression in rat rhabdomyosarcoma induced by Moloney murine sarcoma virus.
Neonatal myosin heavy chains are not expressed in Ni-induced rat rhabdomyosarcoma.
Radio-immunodetection of myosarcoma using 111indium antimyosin.
Rhabdomyosarcoma in a child with massive pleural effusion: cytological diagnosis from pleural fluid.
Smooth and skeletal muscle myosins in spindle cell tumors of soft tissue. An immunohistochemical study.
[A case of multifocal inflammatory pseudotumor of the liver]
[Actomyosin extractable from experimental rat rhabdomyosarcoma.]
[Actomyosin from a low-differentiation skeletal muscle tumor]
[Immunomorphological method in the diagnosis of rhabdomyosarcomas]
[Myosin and actin levels in poorly differentiated skeletal muscle tumors]
Rhabdomyosarcoma, Alveolar
RMZ: a new cell line from a human alveolar rhabdomyosarcoma. In vitro expression of embryonic myosin.
Rhabdomyosarcoma, Embryonal
Development of rhabdomyosarcoma in HER-2/neu transgenic p53 mutant mice.
Expression of muscle-specific actins and myosin in light microscopically undifferentiated small and dark cell malignancies of soft tissues.
Identification of new genes related to the myogenic differentiation arrest of human rhabdomyosarcoma cells.
Immunohistochemical study of alveolar and embryonal rhabdomyosarcoma.
Pleural effusion cytology of embryonal rhabdomyosarcoma.
Rheumatic Diseases
[Delayed hypersensitivity in rheumatism studied using human cardiac myosin]
[Myosin antibody content in rheumatism patients]
[Spreading of antibodies against myosin of cardiac tissue in patients with rheumatism]
Rheumatic Fever
Anti-human cardiac myosin autoantibodies in Kawasaki syndrome.
Autoimmune determinants of rheumatic carditis: localization of epitopes in human cardiac myosin.
Cardiac myosin epitopes for monitoring progression of rheumatic fever.
Cardiac Myosin Epitopes Recognized by Autoantibody in Acute and Convalescent Rheumatic Fever.
Cytotoxic mAb from rheumatic carditis recognizes heart valves and laminin.
Elevated levels of IgG specific antimyosin antibodies in acute rheumatic fever (ARF): differential profiles of antibodies to myosin and soluble myocardial antigens in ARF, acute glomerulonephritis and group A streptococcal pharyngitis.
Epitopes of streptococcal M proteins shared with cardiac myosin.
Human and murine antibodies cross-reactive with streptococcal M protein and myosin recognize the sequence GLN-LYS-SER-LYS-GLN in M protein.
Human monoclonal antibodies reactive with antigens of the group A Streptococcus and human heart.
Induction of myocarditis and valvulitis in lewis rats by different epitopes of cardiac myosin and its implications in rheumatic carditis.
Mimicry in recognition of cardiac myosin peptides by heart-intralesional T cell clones from rheumatic heart disease.
Molecular mimicry in the autoimmune pathogenesis of rheumatic heart disease.
Reactivity of rheumatic fever and scarlet fever patients' sera with group A streptococcal M protein, cardiac myosin, and cardiac tropomyosin: a retrospective study.
[Autoimmune changes in various rheumatic diseases]
Rheumatic Heart Disease
Autoantibodies in the sera of patients with rheumatic heart disease: characterization of myocardial antigens by two-dimensional immunoblotting and N-terminal sequence analysis.
Human and murine antibodies cross-reactive with streptococcal M protein and myosin recognize the sequence GLN-LYS-SER-LYS-GLN in M protein.
Induction of myocarditis and valvulitis in lewis rats by different epitopes of cardiac myosin and its implications in rheumatic carditis.
Mimicry in recognition of cardiac myosin peptides by heart-intralesional T cell clones from rheumatic heart disease.
Rethinking Molecular Mimicry in Rheumatic Heart Disease and Autoimmune Myocarditis: Laminin, Collagen IV, CAR, and B1AR as Initial Targets of Disease.
T cell mimicry and epitope specificity of cross-reactive T cell clones from rheumatic heart disease.
T-Cell-dependent antibody response to the dominant epitope of streptococcal polysaccharide, N-acetyl-glucosamine, is cross-reactive with cardiac myosin.
Rickets
Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors.
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
The content of actomyosin in the skeletal muscle of rats with experimentally induced rickets.
[Actomyosin content of the skeletal muscles in experimental rickets]
Sarcoglycanopathies
Regeneration in sarcoglycanopathies: expression studies of sarcoglycans and other muscle proteins.
Sarcoma
A case of two different tumors in the heart of a dog.
alpha-1-Antitrypsin, alpha-1-antichymotrypsin, actin, and myosin in uterine sarcomas.
Alveolar soft part sarcoma: immunological evidence of rhabdomyoblastic differentiation.
Canine Spindle Cell Mammary Tumor: A Retrospective Study of 67 Cases.
Coenzyme Q10 attenuates platelet integrin ?IIb?3 signaling and platelet hyper-reactivity in ApoE-deficient mice.
Combined small-cell carcinoma of the lung with quadripartite differentiation of epithelial, neuroendocrine, skeletal muscle, and myofibroblastic type.
Differential expression of smooth muscle myosin, smooth muscle actin, h-caldesmon, and calponin in the diagnosis of myofibroblastic and smooth muscle lesions of skin and soft tissue.
Imaging of soft-tissue sarcomas with indium-111-labeled monoclonal antimyosin Fab fragments.
In vitro differentiation of rhabdomyosarcomas induced by nickel or by Moloney murine sarcoma virus.
Infection with Moloney murine sarcoma virus inhibits myogenesis and alters the myogenic-associated (2'-5')oligoadenylate synthetase expression and activity.
MicroRNA-5110 regulates pigmentation by cotargeting melanophilin and WNT family member 1.
Myosin isoform expression in rat rhabdomyosarcoma induced by Moloney murine sarcoma virus.
Physiological control of smooth muscle-specific gene expression through regulated nuclear translocation of serum response factor.
Segregation of a Missense Variant in Enteric Smooth Muscle Actin ?-2 with Autosomal Dominant Familial Visceral Myopathy.
[Effect of vincristine on Mg2+-ATPase activity of actomyosin-like protein from sarcoma-45 and actomyosin from rat skeletal muscle]
Sarcoma, Alveolar Soft Part
Alveolar soft part sarcoma: immunological evidence of rhabdomyoblastic differentiation.
Sarcoma, Avian
Behavior of genes directly injected into the rat heart in vivo.
Identification of potential biomarkers and therapeutic targets for human IgA nephropathy and hypertensive nephropathy by bioinformatics analysis.
Morphological and biochemical analyses of contractile proteins (actin, myosin, caldesmon and tropomyosin) in normal and transformed cells.
Promoter effects of adeno-associated viral vector for transgene expression in the cochlea in vivo.
Sarcoma, Ewing
Immunohistochemical study of alveolar and embryonal rhabdomyosarcoma.
Slow skeletal muscle troponin T, titin and myosin light chain 3 are candidate prognostic biomarkers for Ewing's sarcoma.
Sarcoma, Synovial
Smooth and skeletal muscle myosins in spindle cell tumors of soft tissue. An immunohistochemical study.
Sarcopenia
Analysis of muscle fiber clustering in the diaphragm muscle of sarcopenic mice.
Drastic increase of myosin light chain MLC-2 in senescent skeletal muscle indicates fast-to-slow fibre transition in sarcopenia of old age.
Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans.
Impact of resistance exercise during bed rest on skeletal muscle sarcopenia and myosin isoform distribution.
Protective Effect of Angiotensin 1-7 on Sarcopenia Induced by Chronic Liver Disease in Mice.
Sarcopenia in a mice model of chronic liver disease: role of the ubiquitin-proteasome system and oxidative stress.
The effect of age on protein metabolism.
Scarlet Fever
Reactivity of rheumatic fever and scarlet fever patients' sera with group A streptococcal M protein, cardiac myosin, and cardiac tropomyosin: a retrospective study.
Scoliosis
Contractile protein studies on platelets from patients with idiopathic scoliosis.
Identification of a homozygous frameshift variant in RFLNA in a patient with a typical phenotype of spondylocarpotarsal synostosis syndrome.
Scoliosis surgery in a patient with "de novo" myosin storage myopathy.
Seizures
Bovine Genome-wide Association Study for Genetic Elements to Resist the Infection of Foot-and-mouth Disease in the Field.
Cultured melanocytes from dilute mutant mice exhibit dendritic morphology and altered melanosome distribution.
Myosin Va controls oligodendrocyte morphogenesis and myelination.
Sepsis
Activation of Both the Calpain and Ubiquitin-Proteasome Systems Contributes to Septic Cardiomyopathy through Dystrophin Loss/Disruption and mTOR Inhibition.
Altered phosphorylation and calcium sensitivity of cardiac myofibrillar proteins during sepsis.
Catabolic response to stress and injury: implications for regulation.
Critical illness myopathy: sepsis-mediated failure of the peripheral nervous system.
Differential regulation of myofibrillar proteins in skeletal muscles of septic mice.
Enzymatic changes in myosin regulatory proteins may explain vasoplegia in terminally ill patients with sepsis.
Impact of prolonged sepsis on neural and muscular components of muscle contractions in a mouse model.
Partial inhibition of protein synthesis by Pseudomonas exotoxin A deranges catecholamine sensitivity of cultured rat heart myocytes.
Reduced levels of mRNA for myofibrillar proteins in skeletal muscle from septic rats.
Sepsis stimulates release of myofilaments in skeletal muscle by a calcium-dependent mechanism.
Sepsis-induced myocardial depression is associated with transcriptional changes in energy metabolism and contractile related genes: a physiological and gene expression-based approach.
Sepsis-induced myofibrillar protein catabolism in rat skeletal muscle.
Sepsis: stimulation of energy-dependent protein breakdown resulting in protein loss in skeletal muscle.
Septic cardiomyopathy in rat LPS-induced endotoxemia: relative contribution of cellular diastolic Ca(2+) removal pathways, myofibrillar biomechanics properties and action of the cardiotonic drug levosimendan.
SS31, a mitochondrially targeted antioxidant, prevents sepsis-induced reductions in diaphragm strength and endurance.
The Sick and the Weak: Neuropathies/Myopathies in the Critically Ill.
Severe Fever with Thrombocytopenia Syndrome
Nonmuscle myosin heavy chain IIA is a critical factor contributing to the efficiency of early infection of severe fever with thrombocytopenia syndrome virus.
Shock, Septic
Attenuated platelet aggregation in patients with septic shock is independent from the activity state of myosin light chain phosphorylation or a reduction in Rho kinase-dependent inhibition of myosin light chain phosphatase.
Plasma from septic shock patients induces loss of muscle protein.
Sialic Acid Storage Disease
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Sick Sinus Syndrome
A rare variant in MYH6 is associated with high risk of sick sinus syndrome.
Situs Inversus
DE-Cadherin regulates unconventional Myosin ID and Myosin IC in Drosophila left-right asymmetry establishment.
Developmental expression of Xenopus myosin 1d and identification of a myo1d tail homology that overlaps TH1.
Type ID unconventional myosin controls left-right asymmetry in Drosophila.
Skin Neoplasms
Knockdown of myosin VI by lentivirus-mediated short hairpin RNA suppresses proliferation of melanoma.
Sleep Apnea, Obstructive
Myosin heavy chain proteins are responsible for the development of obstructive sleep apnea syndrome.
Sleep Deprivation
Chronic sleep deprivation alters the myosin heavy chain isoforms in the masseter muscle in rats.
Smooth Muscle Tumor
A comparative study of smooth muscle tumors utilizing light and electron microscopy, immunocytochemical staining and enzymatic assay.
Immunoreactivity of paraffin-embedded normal tissues and mesenchymal tumors for smooth muscle myosin.
Soft Tissue Injuries
Levels of myosin heavy chain fragment in patients with tissue damage.
Spasm
2014 Williams Harvey Lecture: importance of coronary vasomotion abnormalities-from bench to bedside.
Cellular and molecular mechanisms of coronary artery spasm: lessons from animal models.
Enhanced myosin light chain phosphorylations as a central mechanism for coronary artery spasm in a swine model with interleukin-1beta.
Phosphorylated Myosin Light Chain 2 (p-MLC2) as a Molecular Marker of Antemortem Coronary Artery Spasm.
Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm.
Viral myocarditis in children.
[Upregulated Rho-kinase and increased phosphorylation of myosin-binding subunit of myosin phosphates are key players in a porcine coronary artery spasm model with interleukin-1beta]
Spinal Cord Injuries
Changes in detrusor smooth muscle myosin heavy chain mRNA expression following spinal cord injury in the mouse.
Cycling exercise and fetal spinal cord transplantation act synergistically on atrophied muscle following chronic spinal cord injury in rats.
Development and regeneration of the electric organ.
Division of motor units into fast and slow of the basis of profile of 20 Hz unfused tetanus.
Early changes in muscle fiber size and gene expression in response to spinal cord transection and exercise.
Effects of functional electric stimulation cycle ergometry training on lower limb musculature in acute sci individuals.
Myofibrillar ATPase activity of feline muscle fibers expressing slow and fast myosin heavy chains.
Myosin heavy chain isoform and ubiquitin protease mRNA expression after passive leg cycling in persons with spinal cord injury.
Myosin heavy chain isoform mRNA and protein levels after long-term paralysis.
Phenotypic adaptations in human muscle fibers 6 and 24 wk after spinal cord injury.
Prominence of myosin heavy chain hybrid fibers in soleus muscle of spinal cord-transected rats.
Repair of spinal cord transection and its effects on muscle mass and myosin heavy chain isoform phenotype.
Variability in fibre properties in paralysed human quadriceps muscles and effects of training.
[Electroacupuncture Improves Limb Locomotor Function Possibly by Suppressing Rho-ROCK ? Pathway Related Factors in Anterior Horns of Spinal Cord in Rats with Acute Spinal Cord Injury].
Spinal Muscular Atrophies of Childhood
Embryonic and foetal myosins in human skeletal muscle. The presence of foetal myosins in duchenne muscular dystrophy and infantile spinal muscular atrophy.
Myocardial ultrastructural changes in Kugelberg-Welander syndrome.
Werdnig-Hoffmann disease: myosin isoform expression not arrested at prenatal stage of development.
Spinocerebellar Ataxias
Toxicity and endocytosis of spinocerebellar ataxia type 6 polyglutamine domains: role of myosin IIb.
Squamous Cell Carcinoma of Head and Neck
Aberrant Myosin 1b Expression Promotes Cell Migration and Lymph Node Metastasis of HNSCC.
Knockdown of Myosin 6 inhibits proliferation of oral squamous cell carcinoma cells.
Myosin 1b promotes cell proliferation, migration, and invasion in cervical cancer.
Non-muscle myosin II as a predictive factor in head and neck squamous cell carcinoma.
The tumor suppressor capability of p53 is dependent on non-muscle myosin IIA function in head and neck cancer.
Vimentin and Non-Muscle Myosin IIA are Members of the Neural Precursor Cell Expressed Developmentally Down-Regulated 9 (NEDD9) Interactome in Head and Neck Squamous Cell Carcinoma Cells.
[The contractile filament system of carcinoma cells. Immunofluorescent and electron microscopic study]
Stargardt Disease
Hereditary Retinal Dystrophy.
Starvation
Actomyosin content of Physarum plasmodia and detection of immunological cross-reactions with myosins from related species.
Atg1-mediated myosin II activation regulates autophagosome formation during starvation-induced autophagy.
Cellular energetics: actin and myosin abstain from ATP during starvation.
Cloning, purification, crystallization and preliminary crystallographic study of calcium-binding protein 5 from Entamoeba histolytica.
Degradation of transgene-coded and endogenous proteins in the muscles of Caenorhabditis elegans.
Differentiation of rat thymic myoid progenitor cell line established by coculture with human T-lymphotropic virus type-I producing human T cells.
Disproportionate reduction of actin synthesis in hearts of starved rats.
Expression patterns of regulatory lncRNAs and miRNAs in muscular atrophy models induced by starvation in vitro and in vivo.
Immobilization of Jagged1 Enhances Vascular Smooth Muscle Cells Maturation by Activating the Notch Pathway.
Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions.
Metabolic Stress-Induced Activation of AMPK and Inhibition of Constitutive Phosphoproteins Controlling Smooth Muscle Contraction: Evidence for Smooth Muscle Fatigue?
NMMHC IIA triggers neuronal autophagic cell death by promoting F-actin-dependent ATG9A trafficking in cerebral ischemia/reperfusion.
Postprandial resynthesis of myofibrillar proteins is translationally rather than transcriptionally regulated in human skeletal muscle.
Profiles of Physarum Microplasmodial Phosphatase Activity Crucial to Cytoplasmic Streaming and Spherule Formation.
Semi-starvation alters myofibrillar mRNA concentrations to expedite rapid recovery of muscle protein stores following feeding.
Signal transduction events induced by extracellular guanosine 5' triphosphate in excitable cells.
The biosynthesis of plasmodial myosin during starvation of Physarum polycephalum.
Unraveling the role of myosin in forming autophagosomes.
Status Asthmaticus
Acute myopathy with selective degeneration of myosin filaments following status asthmaticus treated with methylprednisolone and vecuronium.
Stomach Neoplasms
Clinicopathological Significance of NMIIA Overexpression in Human Gastric Cancer.
Comprehensive analysis of expression profiles of long non?coding RNAs with associated ceRNA network involved in gastric cancer progression.
Downregulation of non?muscle myosin IIA expression inhibits migration and invasion of gastric cancer cells via the c?Jun N?terminal kinase signaling pathway.
Inhibitory effect of a TGFbeta receptor type-I inhibitor, Ki26894, on invasiveness of scirrhous gastric cancer cells.
LncRNA UCA1 promotes development of gastric cancer via the miR-145/MYO6 axis.
Myosin Heavy Chain-Associated RNA Transcripts Promotes Gastric Cancer Progression Through the miR-4529-5p/ROCK2 Axis.
Overexpression of myosin VI regulates gastric cancer cell progression.
Synergistic combination of DT-13 and topotecan inhibits human gastric cancer via myosin IIA-induced endocytosis of EGF receptor in vitro and in vivo.
The role of the cytoskeleton in migration and proliferation of a cultured human gastric cancer cell line using a new metastasis model.
Strabismus
Histological changes underlying bupivacaine's effect on extra ocular muscle.
The effect of resection on satellite cell activity in rabbit extraocular muscle.
Streptococcal Infections
Autoantibody germ-line gene segment encodes VH and VL regions of a human anti-streptococcal monoclonal antibody recognizing streptococcal M protein and human cardiac myosin epitopes.
Cloning and sequence analysis of a gene encoding a 67-kilodalton myosin-cross-reactive antigen of Streptococcus pyogenes reveals its similarity with class II major histocompatibility antigens.
Induction of myocarditis and valvulitis in lewis rats by different epitopes of cardiac myosin and its implications in rheumatic carditis.
Stroke
A deterministic mechanism producing the loose coupling phenomenon observed in an actomyosin system.
A Drosophila model of dominant inclusion body myopathy 3 shows diminished myosin kinetics that reduce muscle power and yield myofibrillar defects.
A kinetic model that explains the effect of inorganic phosphate on the mechanics and energetics of isometric contraction of fast skeletal muscle.
A model of stereocilia adaptation based on single molecule mechanical studies of myosin I.
A monomeric myosin VI with a large working stroke.
A novel approach to improve cardiac performance: cardiac myosin activators.
A point mutation in the regulatory light chain reduces the step size of skeletal muscle myosin.
A possible mechanism for determining the directionality of myosin molecular motors.
A reverse stroke characterizes the force generation of cardiac myofilaments, leading to an understanding of heart function.
A self-induced translation model of myosin head motion in contracting muscle. I. Force-velocity relation and energy liberation.
A simulation model of the conventional kinesin based on the Driven-by-Detachment mechanism.
A thermodynamic muscle model and a chemical basis for A.V. Hill's muscle equation.
Actin may contribute to the power stroke in the binary actomyosin system.
Actin residue glu(93) is identified as an amino acid affecting myosin binding.
ADP release produces a rotation of the neck region of smooth myosin but not skeletal myosin.
Amplitude of the actomyosin power stroke depends strongly on the isoform of the myosin essential light chain.
An intermediate along the recovery stroke of myosin VI revealed by X-ray crystallography and molecular dynamics.
An Ionic-Chemical-Mechanical Model for Muscle Contraction.
An unexpectedly large working stroke from chymotryptic fragments of myosin II.
Atomically detailed simulation of the recovery stroke in myosin by Milestoning.
Axial and radial forces of cross-bridges depend on lattice spacing.
Basic properties of ATP-induced myosin head movement in hydrated myosin filaments, studied using the gas environmental chamber.
Biological motors: energy storage in myosin molecules.
CaATP prolongs strong actomyosin binding and promotes futile myosin stroke.
CaMKII activity contributes to homeometric autoregulation of the heart: A novel mechanism for the Anrep effect.
Cardiomyopathy mutations impact the actin-activated power stroke of human cardiac myosin.
Cells as liquid motors: Mechanosensitivity emerges from collective dynamics of actomyosin cortex.
Changes at the interface of the N- and C-terminal parts of the heavy chain of myosin subfragment 1.
Changes in the x-ray diffraction pattern from single, intact muscle fibers produced by rapid shortening and stretch.
Changes in the X-ray reflections from contracting muscle during rapid mechanical transients and their structural implications.
Chaperone-enhanced purification of unconventional myosin 15, a molecular motor specialized for stereocilia protein trafficking.
Chaperone-mediated reversible inhibition of the sarcomeric myosin power stroke.
Characterization of the cross-bridge force-generating step using inorganic phosphate and BDM in myofibrils from rabbit skeletal muscles.
Clinical trials update from Heart Rhythm 2008 and Heart Failure 2008: ATHENA, URGENT, INH study, HEART and CK-1827452.
Computational Tool for Ensemble Averaging of Single-Molecule Data.
Considerations on muscle contraction.
Contraction of glycerinated muscle fibers as a function of the ATP concentration.
Correlation between mechanical and enzymatic events in contracting skeletal muscle fiber.
Coupling of lever arm swing and biased Brownian motion in actomyosin.
Cross-bridge action: present views, prospects, and unknowns.
Cross-bridge detachment and attachment following a step stretch imposed on active single frog muscle fibres.
Crossbridge and filament compliance in muscle: implications for tension generation and lever arm swing.
Crystal structure of a vertebrate smooth muscle myosin motor domain and its complex with the essential light chain: visualization of the pre-power stroke state.
Crystal structure of scallop Myosin s1 in the pre-power stroke state to 2.6 a resolution: flexibility and function in the head.
Crystal structure of the motor domain of a class-I myosin.
Detection of single-molecule interactions using correlated thermal diffusion.
Detection of the swings of the lever arm of a myosin motor by fluorescence resonance energy transfer of green and blue fluorescent proteins.
Determination of the myosin step size from mechanical and kinetic data.
Dilated cardiomyopathy mutation in the converter domain of human cardiac myosin alters motor activity and response to omecamtiv mecarbil.
Direct measurements of the coordination of lever arm swing and the catalytic cycle in myosin V.
Direct myosin-2 inhibition enhances cerebral perfusion resulting in functional improvement after ischemic stroke.
Direct observation of the myosin Va recovery stroke that contributes to unidirectional stepping along actin.
Direct real-time detection of the actin-activated power stroke within the myosin catalytic domain.
Direct real-time detection of the structural and biochemical events in the myosin power stroke.
Disrupting the myosin converter-relay interface impairs Drosophila indirect flight muscle performance.
Dissecting Mechanoenzymatic Properties of Processive Myosins with Ultra Force-Clamp Spectroscopy.
Drosophila myosin mutants model the disparate severity of type 1 and type 2B distal arthrogryposis and indicate an enhanced actin affinity mechanism.
Early stages of the recovery stroke in myosin II studied by molecular dynamics simulations.
Effect of fluctuation in step size on actin-myosin sliding motion.
Effect of temperature on the working stroke of muscle myosin.
Elastic distortion of myosin heads and repriming of the working stroke in muscle.
Electron microscopic evidence for the myosin head lever arm mechanism in hydrated myosin filaments using the gas environmental chamber.
Electron microscopic recording of myosin head power stroke in hydrated myosin filaments.
Electron Microscopic Recording of the Power and Recovery Strokes of Individual Myosin Heads Coupled with ATP Hydrolysis: Facts and Implications.
Electron tomography of insect flight muscle in rigor and AMPPNP at 23 degrees C.
Energy economy in the actomyosin interaction: lessons from simple models.
Engineering controllable bidirectional molecular motors based on myosin.
Enhancing diastolic function by strain-dependent detachment of cardiac myosin crossbridges.
Entropic elasticity in the generation of muscle force--a theoretical model.
Exploration of the conformational space of myosin recovery stroke via molecular dynamics.
Fine profile of actomyosin motility fluctuation revealed by using 40-nm probe beads.
Five Alternative Myosin Converter Domains Influence Muscle Power, Stretch Activation, and Kinetics.
Force and number of myosin motors during muscle shortening and the coupling with the release of the ATP hydrolysis products.
Force generation simplified. Insights from laser temperature-jump experiments on contracting muscle fibers.
FRET and optical trapping reveal mechanisms of actin activation of the power stroke and phosphate release in myosin V.
GFP-tagged regulatory light chain monitors single myosin lever-arm orientation in a muscle fiber.
Glycine 699 is pivotal for the motor activity of skeletal muscle myosin.
Heart Failure Drug Modifies the Intrinsic Dynamics of the Pre-Power Stroke State of Cardiac Myosin.
Hemiparetic stroke alters vastus lateralis Myosin heavy chain profiles between the paretic and nonparetic muscles.
Hidden-Markov methods for the analysis of single-molecule actomyosin displacement data: the variance-Hidden-Markov method.
How myosin motors power cellular functions: an exciting journey from structure to function: based on a lecture delivered at the 34th FEBS Congress in Prague, Czech Republic, July 2009.
Human genome comparison of paretic and nonparetic vastus lateralis muscle in patients with hemiparetic stroke.
In vitro actin filament sliding velocities produced by mixtures of different types of myosin.
Induced potential model of muscular contraction mechanism and myosin molecular structure.
Initiation of the power stroke in muscle: insights from the phosphate analog AlF4.
Insertion or deletion of a single residue in the strut sequence of Dictyostelium myosin II abolishes strong binding to actin.
Insight into the mechanism of fast movement of myosin from Chara corallina.
Interactions between relay helix and Src homology 1 (SH1) domain helix drive the converter domain rotation during the recovery stroke of myosin II.
Intradomain distances in the regulatory domain of the myosin head in prepower and postpower stroke states: fluorescence energy transfer.
Investigation into the mechanism of thin filament regulation by transient kinetics and equilibrium binding: Is there a conflict?
Investigation of the Recovery Stroke and ATP Hydrolysis and Changes Caused Due to the Cardiomyopathic Point Mutations in Human Cardiac ? Myosin.
Kinetic analysis of Drosophila muscle myosin isoforms suggests a novel mode of mechanochemical coupling.
Kinetic characterization of nonmuscle myosin IIb at the single molecule level.
Kinetic properties of myosin heavy chain isoforms in single fibers from human skeletal muscle.
Kinetics of ADP dissociation from the trail and lead heads of actomyosin V following the power stroke.
Kinetics of regeneration of cross-bridge power stroke in shortening muscle.
Linear electric traction as an alternative model of the actin/myosin motor.
Load-dependent sliding direction change of a myosin head on an actin molecule and its energetic aspects: Energy borrowing model of a cross-bridge cycle.
Mapping the actin filament with myosin.
Measured and modeled properties of mammalian skeletal muscle: III. the effects of stimulus frequency on stretch-induced force enhancement and shortening-induced force depression.
Mechanics of actomyosin bonds in different nucleotide states are tuned to muscle contraction.
Mechanics of myosin function in white muscle fibres of the dogfish Scyliorhinus canicula.
Mechanics of the power stroke in myosin II.
Mechanics of Vascular Smooth Muscle.
Mechanism of force generation by myosin heads in skeletal muscle.
Mechanism of tension generation in muscle: an analysis of the forward and reverse rate constants.
Mechanistic role of movement and strain sensitivity in muscle contraction.
Mechanochemical coupling in actomyosin energy transduction studied by in vitro movement assay.
Mechanochemical coupling in the myosin motor domain. I. Insights from equilibrium active-site simulations.
Mechanochemical coupling in the myosin motor domain. II. Analysis of critical residues.
Mechanochemical Function of Myosin II: Investigation into the Recovery Stroke and ATP Hydrolysis.
Mechanokinetics of rapid tension recovery in muscle: the Myosin working stroke is followed by a slower release of phosphate.
Metal cation controls phosphate release in the myosin ATPase.
Millisecond Conformational Dynamics of Skeletal Myosin II Power Stroke Studied by High-Speed Atomic Force Microscopy.
Molecular dynamics simulation for the reversed power stroke motion of a myosin subfragment-1.
Molecular dynamics simulation of a myosin subfragment-1 docking with an actin filament.
Molecular mechanical differences between isoforms of contractile actin in the presence of isoforms of smooth muscle tropomyosin.
Molecular modeling of averaged rigor crossbridges from tomograms of insect flight muscle.
Molecular motors: not quite like clockwork.
Motor force homeostasis in skeletal muscle contraction.
Movement of single myosin filaments and myosin step size on an actin filament suspended in solution by a laser trap.
Multidimensional structure-function relationships in human ?-cardiac myosin from population-scale genetic variation.
Multiple- and single-molecule analysis of the actomyosin motor by nanometer-piconewton manipulation with a microneedle: unitary steps and forces.
Muscle proteins--their actions and interactions.
Mutating the converter-relay interface of Drosophila myosin perturbs ATPase activity, actin motility, myofibril stability and flight ability.
Myosin complexed with ADP and blebbistatin reversibly adopts a conformation resembling the start point of the working stroke.
Myosin cross-bridge mechanics: geometrical determinants for continuous sliding.
Myosin head mechanical performance under different conformational change mechanisms.
Myosin individualized: single nucleotide polymorphisms in energy transduction.
Myosin isoforms show different strokes for different blokes.
Myosin lever disposition during length oscillations when power stroke tilting is reduced.
Myosin light chain phosphorylation inhibits muscle fiber shortening velocity in the presence of vanadate.
Myosin S2 origins track evolution of strong binding on actin by azimuthal rolling of motor domain.
Myosin structure: does the tail wag the dog?
Myosin V exhibits a high duty cycle and large unitary displacement.
Myosin VI undergoes a 180{degrees} power stroke implying an uncoupling of the front lever arm.
Myosin VI: a multifunctional motor.
Myosin VI: cellular functions and motor properties.
Myosin with hypertrophic cardiac mutation R712L has a decreased working stroke which is rescued by omecamtiv mecarbil.
Myosin-Specific Adaptations of In vitro Fluorescence Microscopy-Based Motility Assays.
N-terminal splicing extensions of the human MYO1C gene fine-tune the kinetics of the three full-length myosin IC isoforms.
New techniques in linear and non-linear laser optics in muscle research.
Nonlinear elasticity and an 8-nm working stroke of single myosin molecules in myofilaments.
Observation of transient disorder during myosin subfragment-1 binding to actin by stopped-flow fluorescence and millisecond time resolution electron cryomicroscopy: evidence that the start of the crossbridge power stroke in muscle has variable geometry.
Omecamtiv Mecarbil Slows Myosin Kinetics in Skinned Rat Myocardium at Physiological Temperature.
Orientation and dynamics of myosin heads in aluminum fluoride induced pre-power stroke states: an EPR study.
Orientation changes of fluorescent probes at five sites on the myosin regulatory light chain during contraction of single skeletal muscle fibres.
Orientation of intermediate nucleotide states of indane dione spin-labeled myosin heads in muscle fibers.
Orientation of spin labels attached to cross-bridges in contracting muscle fibres.
Overview of the mechanism of cytoskeletal motors based on structure.
Pharmacological activation of myosin II paralogs to correct cell mechanics defects.
Phosphorylation of myosin regulatory light chain has minimal effect on kinetics and distribution of orientations of cross bridges of rabbit skeletal muscle.
Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke.
Rapid regeneration of power stroke in contracting muscle by attachment of second myosin head.
Ratchet-integrated pneumatic actuator (RIPA): A large-stroke soft linear actuator inspired by sarcomere muscle contraction.
Reconciling the working strokes of a single head of skeletal muscle myosin estimated from laser-trap experiments and crystal structures.
Reduced myocardial actomyosin adenosine triphosphatase activity in the ageing male Fischer rat.
Reexamining the origin of the directionality of myosin V.
Regulator of G-Protein Signaling 5 Maintains Brain Endothelial Cell Function in Focal Cerebral Ischemia.
Relationships between chemical and mechanical events during muscular contraction.
Repriming the actomyosin crossbridge cycle.
Reversal of the myosin power stroke induced by fast stretching of intact skeletal muscle fibers.
Reverse conformational changes of the light chain-binding domain of myosin V and VI processive motor heads during and after hydrolysis of ATP by small-angle X-ray solution scattering.
Role of skeletal and smooth muscle myosin light chains.
Role of the lever arm in the processive stepping of myosin V.
Roles of the hydrophobic triplet in the motor domain of myosin in the interaction between myosin and actin.
Searching for kinesin's mechanical amplifier.
Second harmonic generation microscopy probes different states of motor protein interaction in myofibrils.
Selective perturbation of the myosin recovery stroke by point mutations at the base of the lever arm affects ATP hydrolysis and phosphate release.
Simulation of the rapid regeneration of the actin-myosin working stroke with a tight coupling model of muscle contraction.
Simulations of the myosin II motor reveal a nucleotide-state sensing element that controls the recovery stroke.
Single molecule mechanics resolves the earliest events in force generation by cardiac myosin.
Size and speed of the working stroke of cardiac myosin in situ.
Skeletal muscle performance determined by modulation of number of myosin motors rather than motor force or stroke size.
Sliding distance between actin and myosin filaments per ATP molecule hydrolysed in skinned muscle fibres.
Sliding distance of actin filament induced by a myosin crossbridge during one ATP hydrolysis cycle.
Stabilization of the ADP/metaphosphate intermediate during ATP hydrolysis in pre-power stroke myosin: quantitative anatomy of an enzyme.
Step-size of net filament sliding of muscle contraction.
Stochastic dynamics of small ensembles of non-processive molecular motors: the parallel cluster model.
Strain-dependent kinetics of the myosin working stroke, and how they could be probed with optical-trap experiments.
Strong binding of myosin heads stretches and twists the actin helix.
Structural and Computational Insights into a Blebbistatin-Bound Myosin•ADP Complex with Characteristics of an ADP-Release Conformation along the Two-Step Myosin Power Stoke.
Structural change and nucleotide dissociation of Myosin motor domain: dual go model simulation.
Structural changes in myosin motors and filaments during relaxation of skeletal muscle.
Structural coupling of troponin C and actomyosin in muscle fibers.
Structural dynamics of the myosin relay helix by time-resolved EPR and FRET.
Structural kinetics of myosin by transient time-resolved FRET.
Structural mechanism of the recovery stroke in the myosin molecular motor.
Structure-function relation of the myosin motor in striated muscle.
Swing of the lever arm of a myosin motor at the isomerization and phosphate-release steps.
Switch movements and the myosin crossbridge stroke.
Temperature dependence of the force-generating process in single fibres from frog skeletal muscle.
Temperature effect on the chemomechanical regulation of substeps within the power stroke of a single Myosin II.
Tension Recovery following Ramp-Shaped Release in High-Ca and Low-Ca Rigor Muscle Fibers: Evidence for the Dynamic State of AMADP Myosin Heads in the Absence of ATP.
The central domain of UNC-45 chaperone inhibits the myosin power stroke.
The conformation of myosin head domains in rigor muscle determined by X-ray interference.
The contributions of filaments and cross-bridges to sarcomere compliance in skeletal muscle.
The effect of polyethylene glycol on the mechanics and ATPase activity of active muscle fibers.
The effect of the lattice spacing change on cross-bridge kinetics in chemically skinned rabbit psoas muscle fibers. II. Elementary steps affected by the spacing change.
The gated gait of the processive molecular motor, myosin V.
The interrelation between mechanical characteristics of contracting muscle, cross-bridge internal structure, and the mechanism of chemomechanical energy transduction.
The mechanism of the converter domain rotation in the recovery stroke of myosin motor protein.
The Mechanism of the Reverse Recovery Step, Phosphate Release, and Actin Activation of Dictyostelium Myosin II.
The myofilament elasticity and its effect on kinetics of force generation by the myosin motor.
The Myosin C-loop is an Allosteric Actin Contact Sensor in Actomyosin.
The myosin catalytic domain does not rotate during the working power stroke.
The myosin motor in muscle generates a smaller and slower working stroke at higher load.
The myosin power stroke.
The myosin start-of-power stroke state and how actin binding drives the power stroke.
The post-rigor structure of myosin VI and implications for the recovery stroke.
The power stroke causes changes in the orientation and mobility of the termini of essential light chain 1 of myosin.
The power stroke of myosin VI and the basis of reverse directionality.
The prepower stroke conformation of myosin V.
The principal motions involved in the coupling mechanism of the recovery stroke of the myosin motor.
The size and the speed of the working stroke of muscle myosin and its dependence on the force.
The stiffness of rabbit skeletal actomyosin cross-bridges determined with an optical tweezers transducer.
The stroke size of myosins: a reevaluation.
The structural coupling between ATPase activation and recovery stroke in the myosin II motor.
The two mutations of actin-myosin interface and their effect on the dynamics, structures, and functions of skeletal muscle actin.
The working stroke of myosin crossbridges.
The working stroke of the myosin II motor in muscle is not tightly coupled to release of orthophosphate from its active site.
The working stroke upon myosin-nucleotide complexes binding to actin.
Thiol reactivity as a sensor of rotation of the converter in myosin.
Three-dimensional image reconstruction of insect flight muscle. II. The rigor actin layer.
Toward a unified theory of muscle contraction. II: predictions with the mean-field approximation.
Two different rigor complexes of myosin subfragment 1 and actin.
Two independent mechanical events in the interaction cycle of skeletal muscle myosin with actin.
Ultrafast force-clamp spectroscopy of single molecules reveals load dependence of myosin working stroke.
Unconventional Imaging Methods to Capture Transient Structures during Actomyosin Interaction.
Unraveling a Force-Generating Allosteric Pathway of Actomyosin Communication Associated with ADP and Pi Release.
Using optical tweezers to relate the chemical and mechanical cross-bridge cycles.
Visualizing myosin's power stroke in muscle contraction.
Work Done by Titin Protein Folding Assists Muscle Contraction.
X-ray diffraction and electron microscopy from Lethocerus flight muscle partially relaxed by adenylylimidodiphosphate and ethylene glycol.
X-ray diffraction studies of the contractile mechanism in single muscle fibres.
X-ray Diffraction Studies on the Structural Origin of Dynamic Tension Recovery Following Ramp-Shaped Releases in High-Ca Rigor Muscle Fibers.
X-ray interference studies of crossbridge action in muscle contraction: evidence from muscles during steady shortening.
[Are the reciprocal sliding of protofibrils and the shortening of thick filaments during muscle contraction based on a common molecular mechanism?]
[Lever-arm motion and power stroke in myosin motor protein]
[Modulation of S-1 conformation and inhibition of the skeletal muscle S-1-ATPase by calponin of the mussel].
Subarachnoid Hemorrhage
Alterations in protein kinase C activity and membrane lipid metabolism in cerebral vasospasm after subarachnoid hemorrhage.
Attenuation of canine cerebral vasospasm after subarachnoid hemorrhage by protein kinase C inhibitors despite augmented phosphorylation of myosin light chain.
Immunoradiometric assay of serum myosin as a marker of myocardial cell damage: methodological and clinical evaluation.
Myosin light chain phosphorylation and contractile proteins in a canine two-hemorrhage model of subarachnoid hemorrhage.
Synostosis
A postnatal role for embryonic myosin revealed by MYH3 mutations that alter TGF? signaling and cause autosomal dominant spondylocarpotarsal synostosis.
Identification of a homozygous frameshift variant in RFLNA in a patient with a typical phenotype of spondylocarpotarsal synostosis syndrome.
Tachycardia
Myocardial biochemical and hemodynamic adaptations to chronic tachycardia.
Myosin heavy chain synthesis during the progression of chronic tachycardia induced heart failure in rabbits.
[Treatment of heart failure patients with inotropic drugs: beyond traditional agents].
Tachycardia, Ventricular
Subarachnoid hemorrhage and myocardial damage clinical and experimental studies.
Sudden death in mild hypertrophic cardiomyopathy with compound DSG2/DSC2/MYH6 mutations: Revisiting phenotype after genetic assessment in a master runner athlete.
[Factors predictive of early mortality after acute myocardial infarction]
Teratocarcinoma
Expression and localization of villin, fimbrin, and myosin I in differentiating mouse F9 teratocarcinoma cells.
Expression of a murine homeobox gene precedes the induction of c-fos during mesodermal differentiation of P19 teratocarcinoma cells.
Teratoma
Differentiation of murine embryonic stem cells in skeletal muscles of mice.
Timed inhibition of p38MAPK directs accelerated differentiation of human embryonic stem cells into cardiomyocytes.
Testicular Neoplasms
Myoid gonadal stromal tumor: a distinct testicular tumor with peritubular myoid cell differentiation.
Myosin superfamily: The multi-functional and irreplaceable factors in spermatogenesis and testicular tumors.
Myosin Va plays essential roles in maintaining normal mitosis, enhancing tumor cell motility and viability.
Tetanus
A myothermal analysis of the myosin crossbridge cycling rate during isometric tetanus in normal and hypothyroid rat hearts.
A time-resolved X-ray diffraction study of muscle during twitch.
Activation of CD8+ T lymphocytes in insulin-dependent diabetes mellitus.
Activation of T lymphocyte subsets by synthetic TSH receptor peptides and recombinant glutamate decarboxylase in autoimmune thyroid disease and insulin-dependent diabetes.
Analysis of the unfused tetanus course in fast motor units of the rat medial gastrocnemius muscle.
Ca2+ can affect Vmax without changes in myosin light chain phosphorylation in smooth muscle.
Chemical Energetics of contraction in mammalian smooth muscle.
Depression of tetanic force induced by loaded shortening of frog muscle fibres.
Effect of adrenaline on the post-tetanic potentiation in mouse skeletal muscle.
Length-dependence of isometric twitch tension potentiation and myosin phosphorylation in mouse skeletal muscle.
Movements of cross-bridges during and after slow length changes in active frog skeletal muscle.
Myosin light chain phosphorylation does not modulate cross-bridge cycling rate in mouse skeletal muscle.
Myosin light chain phosphorylation during the contraction cycle of frog muscle.
Myosin Va and microtubule-based motors are required for fast axonal retrograde transport of tetanus toxin in motor neurons.
Phosphorylation of the 18,000-dalton light chain of myosin during a single tetanus of frog muscle.
Polyclonal cell activity of a repeat peptide derived from the sequence of an 85-kilodalton surface protein of Trypanosoma cruzi trypomastigotes.
Radial mass transfer of cross-bridges in a tetanized ferret heart muscle.
Structural changes in the myosin filament and cross-bridges during active force development in single intact frog muscle fibres: stiffness and X-ray diffraction measurements.
Structure and function of skeletal muscle in zebrafish early larvae.
Temperature dependence of the force-generating process in single fibres from frog skeletal muscle.
The effects of temperature on the mechanical performance in fatigued single muscle fibers of the frog induced by twitch and tetanus.
The force bearing capacity of frog muscle fibres during stretch: its relation to sarcomere length and fibre width.
The mechanism of the resistance to stretch of isometrically contracting single muscle fibres.
The non-linear elasticity of the muscle sarcomere and the compliance of myosin motors.
Ultraslow myosin molecular motors of placental contractile stem villi in humans.
Tetralogy of Fallot
Cardiac myosin light and heavy chain isotypes in tetralogy of Fallot.
Expression of ventricular myosin subunits in the atria of children with congenital heart malformations.
Nonmuscle myosin II-B is required for normal development of the mouse heart.
Regulation of human heart contractility by essential myosin light chain isoforms.
Thrombasthenia
Analysis of platelet cytoskeleton assembly during platelet activation in Hermansky-Pudlak syndrome and thrombasthenia.
Analysis of VH and VL genes of a monospecific human anti-myosin antibody produced by a B cell from the primary repertoire.
Distribution of myosin, actin and actin-binding protein in thrombasthenic platelets.
Thrombocytopenia
Altered cytoskeleton organization in platelets from patients with MYH9-related disease.
Decreased platelet expression of myosin regulatory light chain polypeptide (MYL9) and other genes with platelet dysfunction and CBFA2/RUNX1 mutation: insights from platelet expression profiling.
First description of somatic mosaicism in MYH9 disorders.
Haematological characteristics of MYH9 disorders due to MYH9 R702 mutations.
Linezolid-Induced Thrombocytopenia Is Caused by Suppression of Platelet Production via Phosphorylation of Myosin Light Chain 2.
Megakaryocyte migration defects due to nonmuscle myosin IIA mutations underlie thrombocytopenia in MYH9-related disease.
Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.
MYH9-related platelet disorders.
MYH9-Related Thrombocytopenia: Four Novel Variants Affecting the Tail Domain of the Non-Muscle Myosin Heavy Chain IIA Associated with a Mild Clinical Evolution of the Disorder.
Non-muscle myosin heavy chain IIA and IIB interact and co-localize in living cells: Relevance for MYH9-related disease.
Nonmuscle myosin heavy chain IIA is a critical factor contributing to the efficiency of early infection of severe fever with thrombocytopenia syndrome virus.
Pal K, Nowak R, Billington N, et al. Megakaryocyte migration defects due to nonmuscle myosin IIA mutations underlie thrombocytopenia in MYH9-related disease. Blood. 2020;135(21):1887-1898.
Perioperative management of MYH9 hereditary macrothrombocytopenia (Fechtner syndrome).
Preoperative use of platelets in a 6-year-old with acute appendicitis and a myosin heavy chain 9-related disorder: a case report and review of literature.
Proplatelet formation deficit and megakaryocyte death contribute to thrombocytopenia in Myh9 knockout mice.
Regulation of platelet myosin light chain (MYL9) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiency.
The value of a native milieu: mutated non-muscle myosin IIA does lead to thrombocytopenia.
Thrombopoietin receptor agonists in hereditary thrombocytopenias.
Thrombosis
Absence of platelet phenotype in mice lacking the motor protein myosin Va.
An inhibitor of myosin II, blebbistatin, suppresses development of arterial thrombosis.
Direct myosin-2 inhibition enhances cerebral perfusion resulting in functional improvement after ischemic stroke.
Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth.
Loss of ATE1-mediated arginylation leads to impaired platelet myosin phosphorylation, clot retraction, and in vivo thrombosis formation.
Myosin IIa is critical for cAMP-mediated endothelial secretion of von Willebrand factor.
NMMHC IIA inhibition impedes tissue factor expression and venous thrombosis via Akt/GSK3?-NF-?B signalling pathways in the endothelium.
Nonmuscle Myosin IIA Regulates Platelet Contractile Forces Through Rho Kinase and Myosin Light-Chain Kinase.
Novel Blood Coagulation Molecules: Skeletal Muscle Myosin and Cardiac Myosin.
Prothrombotic skeletal muscle myosin directly enhances prothrombin activation by binding factors Xa and Va.
Rho GTPase regulation of reactive oxygen species generation and signalling in platelet function and disease.
Substrates of Factor XIII-A: roles in thrombosis and wound healing.
The Myosin II Inhibitor, Blebbistatin, Ameliorates FeCl3-induced Arterial Thrombosis via the GSK3?-NF-?B Pathway.
The Transcription Factor ETV1 Induces Atrial Remodeling and Arrhythmia.
Variations in platelet protein associated with arterial thrombosis.
[Fibrinolysis modulators]
Thymoma
An enzyme-linked immunosorbent assay for antistriational antibodies associated with myasthenia gravis and thymoma: comparison with indirect immunofluorescence.
Anti-skeletal muscle antibodies in the sera from myasthenic patients with thymoma: identification of anti-myosin, actomyosin, actin, and alpha-actinin antibodies by a solid-phase radioimmunoassay and a western blotting analysis.
Autophagy controls neonatal myogenesis by regulating the GH-IGF1 system through a NFE2L2- and DDIT3-mediated mechanism.
Hypertrophic cardiomyopathy and dysregulation of cardiac energetics in a mouse model of biliary fibrosis.
Skeletal muscle-specific Prmt1 deletion causes muscle atrophy via deregulation of the PRMT6-FOXO3 axis.
Thyroid Diseases
The prevalence of autoantibodies to: myosin, troponin, tropomyosin and myoglobin in patients with circulating triiodothyronine and thyroxine autoantibodies (THAA).
Thyroiditis
Natural antibody status in patients with Hashimoto's thyroiditis.
The prevalence of autoantibodies to: myosin, troponin, tropomyosin and myoglobin in patients with circulating triiodothyronine and thyroxine autoantibodies (THAA).
[Immunohistochemical localization of cytoskeletal proteins and thyroglobulin in the follicular cells of Hashimoto's thyroiditis]
Thyrotoxicosis
Acute thyrotoxicosis in the rabbit: changes in cardiac myosin, contractility, and ultrastructure.
Stimulation of cardiac myosin adenosine triphosphatase in thyrotoxicosis.
Toxoplasmosis
Calcium-dependent phosphorylation alters class XIVa myosin function in the protozoan parasite Toxoplasma gondii.
Tremor
Myogenic tremor - a novel tremor entity.
Novel mutations in MYBPC1 are associated with myogenic tremor and mild myopathy.
Trichinellosis
[Organ pathology in chronic tissue-dwelling helminthic infections: role of blood and tissue eosinophilia, immunoglobulinemia E, G4, and immune response-inducing factors]
Tricuspid Valve Insufficiency
[Secondary tricuspid insufficiency and right atrial myosin ATPase activity]
Triple Negative Breast Neoplasms
Integrin ?1, myosin light chain kinase and myosin IIA are required for activation of PI3K-AKT signaling following MEK inhibition in metastatic triple negative breast cancer.
Tuberculosis
An immunosuppressant compound, FK-506, prevents the progression of autoimmune myocarditis in rats.
Cardiosphere-Derived Cells Attenuate Inflammation, Preserve Systolic Function, and Prevent Adverse Remodeling in Rat Hearts With Experimental Autoimmune Myocarditis.
Uremia
Effect of dietary creatine on skeletal muscle myosin heavy chain isoform expression in an animal model of uremia.
Strategies for suppressing muscle atrophy in chronic kidney disease: mechanisms activating distinct proteolytic systems.
Urinary Bladder Diseases
Heterogeneity of bladder myocytes in vitro: modulation of myosin isoform expression.
Urinary Bladder Neck Obstruction
A male murine model of partial bladder outlet obstruction reveals changes in detrusor morphology, contractility and Myosin isoform expression.
Alteration in expression of myosin isoforms in detrusor smooth muscle following bladder outlet obstruction.
Blebbistain, a myosin II inhibitor, as a novel strategy to regulate detrusor contractility in a rat model of partial bladder outlet obstruction.
Contractile protein expression in bladder smooth muscle is a marker of phenotypic modulation after outlet obstruction in the rabbit model.
Deletion of SM-B, the high ATPase isoform of myosin, upregulates the PKC-mediated signal transduction pathway in murine urinary bladder smooth muscle.
Denervation and outlet obstruction induce a net synthesis of contractile and cytoskeletal proteins in the urinary bladder of the male rat.
Enhanced force generation by corpus cavernosum smooth muscle in rabbits with partial bladder outlet obstruction.
Increased corpus cavernosum smooth muscle tone associated with partial bladder outlet obstruction is mediated via Rho-kinase.
Partial bladder outlet obstruction selectively abolishes protein kinase C induced contraction of rabbit detrusor smooth muscle.
Regional alterations in the expression of smooth muscle myosin isoforms in response to partial bladder outlet obstruction.
Urinary Bladder Neoplasms
Calcium control of actin-myosin-based contraction in Triton-treated murine bladder tumor cells.
Non-muscle myosin II is an independent predictor of overall survival for cystectomy candidates with early-stage bladder cancer.
Urinary Bladder, Overactive
Blebbistatin, a Myosin II Inhibitor, Exerts Antidepressant-Like Activity and Suppresses Detrusor Overactivity in an Animal Model of Depression Coexisting with Overactive Bladder.
In vitro and in vivo relaxation of urinary bladder smooth muscle by the selective myosin II inhibitor, blebbistatin.
Suo Quan Wan Protects Mouse From Early Diabetic Bladder Dysfunction by Mediating Motor Protein Myosin Va and Transporter Protein SLC17A9.
Urinary Retention
Social stress in mice induces voiding dysfunction and bladder wall remodeling.
Usher Syndromes
A core cochlear phenotype in USH1 mouse mutants implicates fibrous links of the hair bundle in its cohesion, orientation and differential growth.
Abnormal phagocytosis by retinal pigmented epithelium that lacks myosin VIIa, the Usher syndrome 1B protein.
Ala397Asp mutation of myosin VIIA gene segregating in a Spanish family with type-Ib Usher syndrome.
Analysis of two Arab families reveals additional support for a DFNB2 nonsyndromic phenotype of MYO7A.
Cadherin-23, myosin VIIa and harmonin, encoded by Usher syndrome type I genes, form a ternary complex and interact with membrane phospholipids.
Cargo binding activates myosin VIIA motor function in cells.
Defective myosin VIIA gene responsible for Usher syndrome type 1B.
Detection of a novel Cys628STOP mutation of the myosin VIIA gene in Usher syndrome type Ib.
Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton.
Dual Adeno-Associated Virus Vectors Result in Efficient In Vitro and In Vivo Expression of an Oversized Gene, MYO7A.
Effects of shaker-1 mutations on myosin-VIIa protein and mRNA expression.
Electroretinographic anomalies in mice with mutations in Myo7a, the gene involved in human Usher syndrome type 1B.
Evaluation of the myosin VIIA gene and visual function in patients with Usher syndrome type I.
Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B.
Expression of myosin VIIA during mouse embryogenesis.
Genetic causes of hearing loss.
Genomic structure of the human unconventional myosin VI gene.
Homology modeling and global computational mutagenesis of human myosin VIIa.
Human myosin VIIa is a very slow processive motor protein on various cellular actin structures.
Human myosin VIIA responsible for the Usher 1B syndrome: a predicted membrane-associated motor protein expressed in developing sensory epithelia.
Identification and molecular modelling of a mutation in the motor head domain of myosin VIIA in a family with autosomal dominant hearing impairment (DFNA11).
Identification of a new mutation of the myosin VII head region in Usher syndrome type 1.
Identification of three novel mutations in the MYO7A gene
Identification of three novel mutations in the MYO7A gene.
Impacts of Usher syndrome type IB mutations on human myosin VIIa motor function.
Interactions in the network of Usher syndrome type 1 proteins.
Lentiviral gene replacement therapy of retinas in a mouse model for Usher syndrome type 1B.
Moderate light induced degeneration of rod photoreceptors with delayed transducin translocation in shaker1 mice.
Mutation profile of all 49 exons of the human myosin VIIA gene, and haplotype analysis, in Usher 1B families from diverse origins.
Mutation profile of the MYO7A gene in Spanish patients with Usher syndrome type I.
Mutation spectrum of MYO7A and evaluation of a novel nonsyndromic deafness DFNB2 allele with residual function.
Mutations in myosin VIIA (MYO7A) and usherin (USH2A) in Spanish patients with Usher syndrome types I and II, respectively.
Mutations in the myosin VIIA gene cause a wide phenotypic spectrum, including atypical Usher syndrome.
myosin 7aa(-/-) mutant zebrafish show mild photoreceptor degeneration and reduced electroretinographic responses.
Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction.
Myosin VIIa as a common component of cilia and microvilli.
Myosin VIIA gene: heterogeneity of the mutations responsible for Usher syndrome type IB.
Myosin VIIA mutation screening in 189 Usher syndrome type 1 patients.
Myosin VIIa participates in opsin transport through the photoreceptor cilium.
Myosin VIIa, the product of the Usher 1B syndrome gene, is concentrated in the connecting cilia of photoreceptor cells.
Myosins: Domain Organisation, Motor Properties, Physiological Roles and Cellular Functions.
Novel myosin VI isoform is abundantly expressed in retina.
Outer Retinal Changes Including the Ellipsoid Zone Band in Usher Syndrome 1B due to MYO7A Mutations.
Phenotype of DFNA11: a nonsyndromic hearing loss caused by a myosin VIIA mutation.
Retinal Disease Course in Usher Syndrome 1B due to MYO7A Mutations.
Rhodopsin transport in the membrane of the connecting cilium of mammalian photoreceptor cells.
Role of myosin VIIa and Rab27a in the motility and localization of RPE melanosomes.
Screen for usher syndrome 1B mutations in the ovine myosin VIIa gene.
Shaker-1 mutations reveal roles for myosin VIIA in both development and function of cochlear hair cells.
Structure and Regulation of the Movement of Human Myosin VIIA.
The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals.
The giant spectrin ?V couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route.
The tail binds to the head-neck domain, inhibiting ATPase activity of myosin VIIA.
The usher syndromes.
Twelve novel myosin VIIA mutations in 34 patients with Usher syndrome type I: confirmation of genetic heterogeneity.
Unconventional myosins and the genetics of hearing loss.
Usher I syndrome: unravelling the mechanisms that underlie the cohesion of the growing hair bundle in inner ear sensory cells.
Variable hearing impairment in a DFNB2 family with a novel MYO7A missense mutation.
[Usher syndrome type I and the differentiation of inner ear sensory cells' hair bundles]
Uterine Cervical Neoplasms
Myosin 1b promotes cell proliferation, migration, and invasion in cervical cancer.
The Bidirectional Regulation between MYL5 and HIF-1? Promotes Cervical Carcinoma Metastasis.
Uterine Inertia
Uterine expression of smooth muscle alpha- and gamma-actin and smooth muscle myosin in bitches diagnosed with uterine inertia and obstructive dystocia.
[ATPase activity and fluorescence of myometrial actomyosin in experimental uterine inertia]
Uterine Neoplasms
Genomic Amplification and Functional Dependency of the Gamma Actin Gene ACTG1 in Uterine Cancer.
Uterine Rupture
Morphological estimation of incomplete uterine scar rupture (dehiscence) in post- cesarean deliveries. Immunohistochemical studies.
Vascular Diseases
Between Rho(k) and a Hard Place: The Relation Between Vessel Wall Stiffness, Endothelial Contractility, and Cardiovascular Disease.
Calcium antagonists and vascular smooth muscle cells in atherogenesis.
Myosin gene expression and cell phenotypes in vascular smooth muscle during development, in experimental models, and in vascular disease.
Vascular System Injuries
Alterations in expression of myosin and myosin light chain kinases in response to vascular injury.
Perivascular Delivery of Blebbistatin Reduces Neointimal Hyperplasia Following Carotid Injury in the Mouse.
Vasoplegia
Enzymatic changes in myosin regulatory proteins may explain vasoplegia in terminally ill patients with sepsis.
Vasospasm, Intracranial
Attenuation of canine cerebral vasospasm after subarachnoid hemorrhage by protein kinase C inhibitors despite augmented phosphorylation of myosin light chain.
Interactive role of protein kinase C-delta with rho-kinase in the development of cerebral vasospasm in a canine two-hemorrhage model.
Intracellular calcium, myosin light chain phosphorylation, and contractile force in experimental cerebral vasospasm.
Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm.
The presence of an extractable substance in the CSF of humans with cerebral vasospasm after subarachnoid haemorrhage that correlates with phosphatase inhibition.
Venous Thrombosis
The saponin D39 blocks dissociation of non-muscular myosin heavy chain IIA from TNF receptor 2, suppressing tissue factor expression and venous thrombosis.
[Immunoscintigraphy]
Ventricular Dysfunction
Atrial contractile protein content and function are preserved in patients with coronary artery disease and atrial fibrillation.
Development of dilated cardiomyopathy in Bmal1-deficient mice.
Ventricular Dysfunction, Left
A novel missense mutation in the myosin binding protein-C gene is responsible for hypertrophic cardiomyopathy with left ventricular dysfunction and dilation in elderly patients.
Calcium/calmodulin-dependent protein kinase II couples Wnt signaling with histone deacetylase 4 and mediates dishevelled-induced cardiomyopathy.
Immunoglobulin G3 cardiac myosin autoantibodies correlate with left ventricular dysfunction in patients with dilated cardiomyopathy: immunoglobulin G3 and clinical correlates.
Modulation of in vivo cardiac hypertrophy with insulin-like growth factor-1 and angiotensin-converting enzyme inhibitor: relationship between change in myosin isoform and progression of left ventricular dysfunction.
Ventricular Dysfunction, Right
Recessive MYH6 Mutations in Hypoplastic Left Heart With Reduced Ejection Fraction.
Ventricular Fibrillation
Dietary omega-3 fatty acids attenuate myocardial arrhythmogenic factors and propensity of the heart to lethal arrhythmias in a rodent model of human essential hypertension.
Subarachnoid hemorrhage and myocardial damage clinical and experimental studies.
Transient ventricular fibrillation and myosin heavy chain isoform profile.
Ventricular Outflow Obstruction
Mavacamten - a new disease-specific option for pharmacological treatment of symptomatic patients with hypertrophic cardiomyopathy.
Vesicular Stomatitis
An alternative fixation-processing method for preembedding ultrastructural immunocytochemistry of cytoplasmic antigens: the GBS (glutaraldehyde-borohydride-saponin) procedure.
Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis.
Virus Diseases
Autoimmunity in coxsackievirus infection.
Effect of Deltex-1 on proliferation and differentiation of bone marrow mesenchymal stem cells into smooth muscle cells.
Interaction of c-Cbl with myosin IIA regulates Bleb associated macropinocytosis of Kaposi's sarcoma-associated herpesvirus.
Mouse cytomegalovirus infection induces antibodies which cross-react with virus and cardiac myosin: a model for the study of molecular mimicry in the pathogenesis of viral myocarditis.
Myosins VIII and XI play distinct roles in reproduction and transport of tobacco mosaic virus.
Pathogenesis of myocardial injury in myocarditis and cardiomyopathy.
Phosphorylation is required for myosin regulatory light chain (PmMRLC) to control yellow head virus infection in shrimp hemocytes.
Spontaneous autoimmune myocarditis and cardiomyopathy in HLA-DQ8.NODAbo transgenic mice.
Spontaneous myocarditis mimicking human disease occurs in the presence of an appropriate MHC and non-MHC background in transgenic mice.
The pathogenesis of postinfectious myocarditis.
The significance of autoimmunity in myocarditis.
Use of a tandem affinity purification assay to detect interactions between West Nile and dengue viral proteins and proteins of the mosquito vector.
Vision Disorders
Actin filaments in contracting preretinal membranes.
myosin 7aa(-/-) mutant zebrafish show mild photoreceptor degeneration and reduced electroretinographic responses.
The usher syndromes.
Vitamin A Deficiency
Moderate maternal vitamin A deficiency alters myogenic regulatory protein expression and perinatal organ growth in the rat.
Vitamin D Deficiency
Disrupted expression of genes essential for skeletal muscle fibre integrity and energy metabolism in Vitamin D deficient rats.
Vitamin D deficiency impairs skeletal muscle function in a smoking mouse model.
Vitreoretinopathy, Proliferative
[Contractile elements in proliferative retinal diseases]
von Hippel-Lindau Disease
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus.
Walker-Warburg Syndrome
Target resequencing of neuromuscular disease-related genes using next-generation sequencing for patients with undiagnosed early-onset neuromuscular disorders.
Warts
Cytoskeletal tension inhibits Hippo signaling through an Ajuba-Warts complex.
Fat/Dachsous Signaling Promotes Drosophila Wing Growth by Regulating the Conformational State of the NDR Kinase Warts.
The palmitoyltransferase Approximated promotes growth via the Hippo pathway by palmitoylation of Fat.
West Nile Fever
Use of a tandem affinity purification assay to detect interactions between West Nile and dengue viral proteins and proteins of the mosquito vector.
Whooping Cough
Beneficial role of simvastatin in experimental autoimmune myositis.
Dendritic cells distinguish individual chemokine signals through CCR7 and CXCR4.
Development of an improved animal model of experimental autoimmune myositis.
Dual effects of hexanol and halothane on the regulation of calcium sensitivity in airway smooth muscle.
Interleukin-37 (IL-37) Suppresses Pertussis Toxin-Induced Inflammatory Myopathy in a Rat Model.
Pertussis toxin-induced redistribution of cortical actomyosin and inhibition of phagocytosis in rat Kupffer cells.
Rho-mediated phosphorylation of focal adhesion kinase and myosin light chain in human endothelial cells stimulated with sphingosine 1-phosphate, a bioactive lysophospholipid released from activated platelets.
Wilms Tumor
Effect of growth selection of broilers on breast muscle satellite cell function: Response of satellite cells to NOV, COMP, MYBP-C1, and CSRP3.
Embryonic myosin heavy chain as a differentiation marker of developing human skeletal muscle and rhabdomyosarcoma. A monoclonal antibody study.
Immunohistochemical distinction of endometrial stromal sarcoma and cellular leiomyoma.
Skeletal muscle differentiation in Wilms' tumor. Antibody identification and explant culture.
Wiskott-Aldrich Syndrome
Cdc42 antagonizes Rho1 activity at adherens junctions to limit epithelial cell apical tension.
Cytoskeletal tension actively sustains the migratory T-cell synaptic contact.
Formation of a WIP-, WASp-, actin-, and myosin IIA-containing multiprotein complex in activated NK cells and its alteration by KIR inhibitory signaling.
Mechanisms of host cell exit by the intracellular bacterium Chlamydia.
Role of Rho-GTPases in megakaryopoiesis.
Thrombopoietin receptor agonists in hereditary thrombocytopenias.
UNC-45A Is a Nonmuscle Myosin IIA Chaperone Required for NK Cell Cytotoxicity via Control of Lytic Granule Secretion.