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Information on EC 5.6.1.3 - plus-end-directed kinesin ATPase
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5.6.1.3 plus-end-directed kinesin ATPaseIUBMB Comments
Kinesins are a family of motor proteins that move unidirectionally along microtubules as they hydrolyse ATP. The enzymes described here move towards the plus end of the microtubule, in contrast to EC 5.6.1.2, dynein ATPase and EC 5.6.1.4, minus-end-directed kinesin ATPase. They are involved in organelle movement in mitosis and meiosis, and also power vesicular trafficking toward the synapse in neurons. The motor domain, which contains the ATP- and microtubule-binding activities, is located at the N-terminus while the C-terminus links to the cargo being transported.
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Word Map
- 5.6.1.3
- microtubule
- spindle
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cargo
- dynein
- axon
-
mitosis
- drosophila
- tubulin
- myosin
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microtubule-based
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anterograde
-
cytokinesis
- cytoskeleton
- actin
-
bipolar
- cilia
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single-molecule
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glide
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depolymerization
- centrosome
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microtubule-associated
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retrograde
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coiled-coil
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metaphase
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anaphase
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interphase
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gliding
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mechanochemical
- kinetochore
-
microtubule-dependent
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intraflagellar
- plus-ends
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microtubule-binding
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protofilaments
- medicine
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microtubule-organizing
- pharmacology
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dynactin
-
astral
-
mtocs
-
midzone
- axoneme
-
ciliogenesis
-
monopolar
- cdc20
-
aurora
-
prometaphase
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depolymerase
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actin-based
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force-generating
- midbody
- ciliopathies
The enzyme appears in viruses and cellular organisms
Synonyms
kinesin, kinesin-1, kif3a, kinesin-5, kif1a, kif11, kif4a, kifc1, kinesin-2, kif5b, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
kinesin
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric ester
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SYSTEMATIC NAME
IUBMB Comments
kinesin ATP phosphohydrolase (plus-end-directed)
Kinesins are a family of motor proteins that move unidirectionally along microtubules as they hydrolyse ATP. The enzymes described here move towards the plus end of the microtubule, in contrast to EC 5.6.1.2, dynein ATPase and EC 5.6.1.4, minus-end-directed kinesin ATPase. They are involved in organelle movement in mitosis and meiosis, and also power vesicular trafficking toward the synapse in neurons. The motor domain, which contains the ATP- and microtubule-binding activities, is located at the N-terminus while the C-terminus links to the cargo being transported.
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CAS REGISTRY NUMBER
COMMENTARY
9000-83-3
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + H2O + a kinesin associated with a microtubule at position n
ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
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?
additional information
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the KVD motif of kinesin Kif2C interacts directly with tubulin. ATP hydrolysis in Kif2C is not required for tubulin release
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?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + H2O + a kinesin associated with a microtubule at position n
ADP + phosphate + a kinesin associated with a microtubule at position n+1 (toward the plus end)
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-
?
additional information
?
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the KVD motif of kinesin Kif2C interacts directly with tubulin. ATP hydrolysis in Kif2C is not required for tubulin release
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-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
tubulin-vinblastine assemblies
stimulation of the ATPase activity of the enzyme
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
The large GTPase Mx1 binds KIF5B for cargo transport along microtubules.
Acrocallosal Syndrome
Olfactory bulb and olfactory tract abnormalities in acrocallosal syndrome and Greig cephalopolysyndactyly syndrome.
Acrocallosal Syndrome
Structural insights into human Kif7, a kinesin involved in Hedgehog signalling.
Acrocephalosyndactylia
Developmental expression of specific genes detected in high-quality cDNA libraries from single human preimplantation embryos.
Acute Kidney Injury
Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia.
Adenocarcinoma
A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian adenocarcinomas.
Adenocarcinoma
KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling.
Adenocarcinoma
Kinesin Eg5 Targeting Inhibitors as a New Strategy for Gastric Adenocarcinoma Treatment.
Adenocarcinoma
Preliminary study on the clinical significance of kinesin Kif18a in nonsmall cell lung cancer: An analysis of 100 cases.
Adenocarcinoma
Prognostic Significance of KIF11 and KIF14 Expression in Pancreatic Adenocarcinoma.
Adenocarcinoma of Lung
A rare KIF5B-ALK fusion variant in a lung adenocarcinoma patient who responded to crizotinib and acquired the ALK L1196M mutation after resistance: a case report.
Adenocarcinoma of Lung
A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing.
Adenocarcinoma of Lung
Cabozantinib for the treatment of non-small cell lung cancer with KIF5B-RET fusion. An example of swift repositioning.
Adenocarcinoma of Lung
Clinical Significance And Integrative Analysis Of Kinesin Family Member 18B In Lung Adenocarcinoma.
Adenocarcinoma of Lung
Co-expression network analysis identified KIF2C in association with progression and prognosis in lung adenocarcinoma.
Adenocarcinoma of Lung
Genome?wide investigation of the clinical significance and prospective molecular mechanisms of kinesin family member genes in patients with lung adenocarcinoma.
Adenocarcinoma of Lung
High EGFR_1 Inside-Out Activated Inflammation-Induced Motility through SLC2A1-CCNB2-HMMR-KIF11-NUSAP1-PRC1-UBE2C.
Adenocarcinoma of Lung
High KIF2A expression promotes proliferation, migration and predicts poor prognosis in lung adenocarcinoma.
Adenocarcinoma of Lung
High kinesin family member 18A expression correlates with poor prognosis in primary lung adenocarcinoma.
Adenocarcinoma of Lung
Identification of KIF4A and its effect on the progression of lung adenocarcinoma based on the bioinformatics analysis.
Adenocarcinoma of Lung
Increased KIF15 Expression Predicts a Poor Prognosis in Patients with Lung Adenocarcinoma.
Adenocarcinoma of Lung
Integrated analysis reveals key genes with prognostic value in lung adenocarcinoma.
Adenocarcinoma of Lung
KIF11 Serves as an Independent Prognostic Factor and Therapeutic Target for Patients With Lung Adenocarcinoma.
Adenocarcinoma of Lung
Kinesin 12 (KIF15) contributes to the development and tumorigenicity of prostate cancer.
Adenocarcinoma of Lung
Kinesin Family Member 18A (KIF18A) Contributes to the Proliferation, Migration, and Invasion of Lung Adenocarcinoma Cells In Vitro and In Vivo.
Adenocarcinoma of Lung
Kinesin KIF4A is associated with chemotherapeutic drug resistance by regulating intracellular trafficking of lung resistance-related protein.
Adenocarcinoma of Lung
Oncogenic Function of a KIF5B-MET Fusion Variant in Non-Small Cell Lung Cancer.
Adenocarcinoma of Lung
Overexpression of KIF18A promotes cell proliferation, inhibits apoptosis, and independently predicts unfavorable prognosis in lung adenocarcinoma.
Adenocarcinoma of Lung
Progress in Discovery of KIF5B-RET Kinase Inhibitors for the Treatment of Non-Small-Cell Lung Cancer.
Adenocarcinoma of Lung
RET expression and detection of KIF5B/RET gene rearrangements in Japanese lung cancer.
Adenocarcinoma of Lung
Therapeutic Targeting of the Premetastatic Stage in Human Lung-to-Brain Metastasis.
Adenomatous Polyposis Coli
A reconstituted mammalian APC-kinesin complex selectively transports defined packages of axonal mRNAs.
Adenomatous Polyposis Coli
A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila.
Adenomatous Polyposis Coli
APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity.
Adenomatous Polyposis Coli
Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia-like phenotypes in mice.
Adenomatous Polyposis Coli
Proto-Oncogenic Src Phosphorylates EB1 to Regulate the Microtubule-Focal Adhesion Crosstalk and Stimulate Cell Migration.
Adenomatous Polyposis Coli
Suppression of kinesin expression disrupts adenomatous polyposis coli (APC) localization and affects beta-catenin turnover in young adult mouse colon (YAMC) epithelial cells.
Adenomatous Polyposis Coli
Tumour Suppressor Adenomatous Polyposis Coli (APC) localisation is regulated by both Kinesin-1 and Kinesin-2.
African Swine Fever
Transport of African swine fever virus from assembly sites to the plasma membrane is dependent on microtubules and conventional kinesin.
Alopecia
Exploring the possibility of predicting human head hair greying from DNA using whole-exome and targeted NGS data.
Alzheimer Disease
Amyloid-beta-dependent phosphorylation of collapsin response mediator protein-2 dissociates kinesin in Alzheimer's disease.
Alzheimer Disease
Association study of three polymorphisms of kinesin light-chain 1 gene with Alzheimer's disease.
Alzheimer Disease
Atlas stumbled: kinesin light chain-1 variant E triggers a vicious cycle of axonal transport disruption and amyloid-? generation in Alzheimer's disease.
Alzheimer Disease
GSK3? Impairs KIF1A Transport in a Cellular Model of Alzheimer's Disease but Does Not Regulate Motor Motility at S402.
Alzheimer Disease
Inhibition of interleukin-1? plays a protective role in Alzheimer's disease by promoting microRNA-9-5p and downregulating targeting protein for xenopus kinesin-like protein 2.
Alzheimer Disease
Kinesin gene variability may affect tau phosphorylation in early Alzheimer's disease.
Alzheimer Disease
Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer's disease and regulates axonal transport and processing of the amyloid precursor protein.
Alzheimer Disease
Kinesin light chain-1 variant E disrupts axonal transport and A? generation in Alzheimer's disease (comment on DOI 10.1002/bies.201400131).
Alzheimer Disease
Levels of kinesin light chain and dynein intermediate chain are reduced in the frontal cortex in Alzheimer's disease: implications for axoplasmic transport.
Alzheimer Disease
LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer's disease brains.
Alzheimer Disease
Overexpression of Kinesin Superfamily Motor Proteins in Alzheimer's Disease.
Alzheimer Disease
Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking.
Alzheimer Disease
Presenilin influences Glycogen Synthase Kinase-3beta (GSK-3?) for kinesin-1 and dynein function during axonal transport.
Alzheimer Disease
The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites.
Alzheimer Disease
The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport.
Alzheimer Disease
Up-regulation of kinesin light-chain 1 gene expression by acetyl-L-carnitine: therapeutic possibility in Alzheimer's disease.
Alzheimer Disease
Variability in the kinesin light chain 1 gene may influence risk of age-related cataract.
Amyotrophic Lateral Sclerosis
Cohort Analysis of 67 Charcot-Marie-Tooth Italian Patients: Identification of New Mutations and Broadening of Phenotype Expression Produced by Rare Variants.
Amyotrophic Lateral Sclerosis
Generation of two induced pluripotent stem cell (iPSC) lines from an ALS patient with simultaneous mutations in KIF5A and MATR3 genes.
Amyotrophic Lateral Sclerosis
Genetic and functional analysis of KIF5A variants in Japanese patients with sporadic amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Genotype-phenotype correlations of KIF5A stalk domain variants.
Amyotrophic Lateral Sclerosis
KIF5A and ALS2 Variants in a Family With Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis.
Amyotrophic Lateral Sclerosis
Kinesin Expression in the Central Nervous System of Humans and Transgenic hSOD1G93A Mice with Amyotrophic Lateral Sclerosis.
Amyotrophic Lateral Sclerosis
Molecular analysis and clinical diversity of distal hereditary motor neuropathy.
Amyotrophic Lateral Sclerosis
Mutation analysis of KIF5A in Chinese amyotrophic lateral sclerosis patients.
Amyotrophic Lateral Sclerosis
Mutation screening of the KIF5A gene in Chinese patients with amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Splice-site mutations in KIF5A in the Japanese case series of amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Sural biopsy to detect the axonal cytoskeleton defects in KIF5A-related Charcot-Marie-Tooth disease type 2.
Amyotrophic Lateral Sclerosis
Whole exome sequencing and the clinician: we need clinical skills and functional validation in variant filtering.
Amyotrophic Lateral Sclerosis
Whole-exome sequencing identified novel KIF5A mutations in Chinese patients with amyotrophic lateral sclerosis and Charcot-Marie-Tooth type 2.
Anaphylaxis
Kinesin-1 controls mast cell degranulation and anaphylaxis through PI3K-dependent recruitment to the granular Slp3/Rab27b complex.
Anemia
A nuclear kinesin-like protein interacts with and stimulates the activity of the leucine-rich nuclear export signal of the human immunodeficiency virus type 1 rev protein.
Anemia
Congenital dyserythropoietic anemia type III (CDA III) is caused by a mutation in kinesin family member, KIF23.
Anemia, Dyserythropoietic, Congenital
Congenital dyserythropoietic anemia type III (CDA III) is caused by a mutation in kinesin family member, KIF23.
Anthrax
Quickening the pace of anthrax research: three advances point towards possible therapies.
Apnea
Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta.
Apnea
KIF5A mutations cause an infantile onset phenotype including severe myoclonus with evidence of mitochondrial dysfunction.
Asthma
Genetic variations in KIFC1 and the risk of aspirin exacerbated respiratory disease in a Korean population: an association analysis.
Asthma
Identification of KIF3A as a novel candidate gene for childhood asthma using RNA expression and population allelic frequencies differences.
Asthma
Identification of two early life eczema and non-eczema phenotypes with high risk for asthma development.
Asthma
KIF3A genetic variation is associated with pediatric asthma in the presence of eczema independent of allergic rhinitis.
Asthma
KIF3A knockdown sensitizes bronchial epithelia to apoptosis and aggravates airway inflammation in asthma.
Asthma
KIF3A, a Cilia Structural Gene on Chromosome 5q31, and Its Polymorphisms Show an Association with Aspirin Hypersensitivity in Asthma.
Asthma
MicroRNA-145-5p promotes asthma pathogenesis by inhibiting kinesin family member 3A expression in mouse airway epithelial cells.
Astrocytoma
Expression of targeting protein for Xenopus kinesin-like protein 2 is associated with progression of human malignant astrocytoma.
Ataxia
BNIP-2 binds phosphatidylserine, localizes to vesicles, and is transported by kinesin-1.
Ataxia
Cayman ataxia protein caytaxin is transported by kinesin along neurites through binding to kinesin light chains.
Ataxia
Defective kinesin binding of TUBB2A causes progressive spastic ataxia syndrome resembling sacsinopathy.
Ataxia
Heterozygous KIF1A variants underlie a wide spectrum of neurodevelopmental and neurodegenerative disorders.
Ataxia
Neuronal KIF5b deletion induces striatum-dependent locomotor impairments and defects in membrane presentation of dopamine D2 receptors.
Autoimmune Diseases
Association of KIF21B genetic polymorphisms with ankylosing spondylitis in a Chinese Han population of Shandong Province.
Autoimmune Diseases
Identification of Orch3, a locus controlling dominant resistance to autoimmune orchitis, as kinesin family member 1C.
Autoimmune Diseases
IRF5, PTPN22, CD28, IL2RA, KIF5A, BLK and TNFAIP3 genes polymorphisms and lupus susceptibility in a cohort from the Egypt Delta; relation to other ethnic groups.
Bardet-Biedl Syndrome
Kinesin 1 regulates cilia length through an interaction with the Bardet-Biedl syndrome related protein CCDC28B.
Bardet-Biedl Syndrome
Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport.
Bone Diseases, Metabolic
Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia.
Bone Diseases, Metabolic
Impairment of Primary Cilia Contributes to Visceral Adiposity of High Fat Diet-Fed Mice.
Bone Neoplasms
Kinesin superfamily protein 17 contributes to the development of bone cancer pain by participating in NR2B transport in the spinal cord of mice.
Brain Diseases
De novo mutations in KIF1A cause progressive encephalopathy and brain atrophy.
Brain Injuries
Neuroprotection Exerted by Netrin-1 and Kinesin Motor KIF1A in Secondary Brain Injury following Experimental Intracerebral Hemorrhage in Rats.
Brain Injuries, Traumatic
Immunolocalization of dynein, dynactin, and kinesin in the cerebral tissue as a possible supplemental diagnostic tool for traumatic brain injury in postmortem examination.
Brain Ischemia
Kinesin-1 Regulates Extrasynaptic Targeting of NMDARs and Neuronal Vulnerability Toward Excitotoxicity.
Brain Ischemia
[Effect of hypothermia on activities of tubule motor protein and constructure protein after cerebral ischemia in gerbils].
Brain Neoplasms
Integrative analysis of KIF4A, 9, 18A, and 23 and their clinical significance in low-grade glioma and glioblastoma.
Brain Neoplasms
KIF11 inhibition for glioblastoma treatment: reason to hope or a struggle with the brain?
Breast Neoplasms
A multi-layer inference approach to reconstruct condition-specific genes and their regulation.
Breast Neoplasms
A role for kinesin-1 subunits KIF5B/KLC1 in regulating epithelial mesenchymal plasticity in breast tumorigenesis.
Breast Neoplasms
An integrated bioinformatical analysis to evaluate the role of KIF4A as a prognostic biomarker for breast cancer.
Breast Neoplasms
Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells.
Breast Neoplasms
Breast tumor kinase BRK requires kinesin-2 subunit KAP3A in modulation of cell migration.
Breast Neoplasms
Central spindle proteins and mitotic kinesins are direct transcriptional targets of MuvB, B-MYB and FOXM1 in breast cancer cell lines and are potential targets for therapy.
Breast Neoplasms
Centrosome Clustering Is a Tumor-selective Target for the Improvement of Radiotherapy in Breast Cancer Cells.
Breast Neoplasms
Chromosomally unstable tumor cells specifically require KIF18A for proliferation.
Breast Neoplasms
Circular RNA KIF4A promotes cell migration, invasion and inhibits apoptosis through miR-152/ZEB1 axis in breast cancer.
Breast Neoplasms
Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer.
Breast Neoplasms
Differential promoter methylation of kinesin family member 1a in plasma is associated with breast cancer and DNA repair capacity.
Breast Neoplasms
Distinct Diagnostic and Prognostic Values of Kinesin Family Member Genes Expression in Patients with Breast Cancer.
Breast Neoplasms
Down-regulation of KIF2A inhibits gastric cancer cell invasion via suppressing MT1-MMP.
Breast Neoplasms
Effects of TPX2 gene on radiotherapy sensitization in breast cancer stem cells.
Breast Neoplasms
Enhanced expression of KIF4A in colorectal cancer is associated with lymph node metastasis.
Breast Neoplasms
Genetic and functional analyses do not explain the association of high PRC1 expression with poor survival of breast carcinoma patients.
Breast Neoplasms
High expression of KIF3A is a potential new parameter for the diagnosis and prognosis of breast cancer.
Breast Neoplasms
High KIF2A expression promotes proliferation, migration and predicts poor prognosis in lung adenocarcinoma.
Breast Neoplasms
High kinesin family member 18A expression correlates with poor prognosis in primary lung adenocarcinoma.
Breast Neoplasms
Human Mitotic Centromere-Associated Kinesin Is Targeted by MicroRNA 485-5p/181c and Prognosticates Poor Survivability of Breast Cancer.
Breast Neoplasms
Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.
Breast Neoplasms
Identification of epithelial-mesenchymal transition-related circRNA-miRNA-mRNA ceRNA regulatory network in breast cancer.
Breast Neoplasms
Identification of five hub genes as monitoring biomarkers for breast cancer metastasis in silico.
Breast Neoplasms
Identification of key genes unique to the luminal a and basal-like breast cancer subtypes via bioinformatic analysis.
Breast Neoplasms
Identification of Potential Crucial Genes and Key Pathways in Breast Cancer Using Bioinformatic Analysis.
Breast Neoplasms
Identification of potential prognostic biomarkers for breast cancer using WGCNA and PPI integrated techniques.
Breast Neoplasms
Impact of kinesin Eg5 inhibition by 3,4-dihydropyrimidin-2(1H)-one derivatives on various breast cancer cell features.
Breast Neoplasms
Involvement of kinesin family member 2C/mitotic centromere-associated kinesin overexpression in mammary carcinogenesis.
Breast Neoplasms
KIF11 Functions as an Oncogene and Is Associated with Poor Outcomes from Breast Cancer.
Breast Neoplasms
KIF11 is required for proliferation and self-renewal of docetaxel resistant triple negative breast cancer cells.
Breast Neoplasms
KIF14 mRNA expression is a predictor of grade and outcome in breast cancer.
Breast Neoplasms
Kinesin 12 (KIF15) contributes to the development and tumorigenicity of prostate cancer.
Breast Neoplasms
Kinesin Family Deregulation Coordinated by Bromodomain Protein ANCCA and Histone Methyltransferase MLL for Breast Cancer Cell Growth, Survival, and Tamoxifen Resistance.
Breast Neoplasms
Kinesin family member 11 contributes to the progression and prognosis of human breast cancer.
Breast Neoplasms
Kinesin Family Member 11 Enhances the Self-Renewal Ability of Breast Cancer Cells by Participating in the Wnt/?-Catenin Pathway.
Breast Neoplasms
Kinesin family member 11 is a potential therapeutic target and is suppressed by microRNA-30a in breast cancer.
Breast Neoplasms
Kinesin superfamily: roles in breast cancer, patient prognosis and therapeutics.
Breast Neoplasms
Kinesin-1 translocation: Surprising differences between bovine brain and MCF7-derived microtubules.
Breast Neoplasms
Knockdown of kinesin KIF11 abrogates directed migration in response to epidermal growth factor-mediated chemotaxis.
Breast Neoplasms
Local anesthetics inhibit kinesin motility and microtentacle protrusions in human epithelial and breast tumor cells.
Breast Neoplasms
Multi-institutional study of nuclear KIFC1 as a biomarker of poor prognosis in African American women with triple-negative breast cancer.
Breast Neoplasms
Overexpression of kinesin superfamily members as prognostic biomarkers of breast cancer.
Breast Neoplasms
Overexpression of kinesins mediates docetaxel resistance in breast cancer cells.
Breast Neoplasms
Positive expression of KIF20A indicates poor prognosis of glioma patients.
Breast Neoplasms
Prognostic and clinicopathological significance of kinesin family member C1 in various cancers: A meta-analysis.
Breast Neoplasms
Silencing of KIF3B Suppresses Breast Cancer Progression by Regulating EMT and Wnt/?-Catenin Signaling.
Breast Neoplasms
Specific kinesin expression profiles associated with taxane resistance in basal-like breast cancer.
Breast Neoplasms
Suppression of KIF3A inhibits triple negative breast cancer growth and metastasis by repressing Rb-E2F signaling and epithelial-mesenchymal transition.
Breast Neoplasms
Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF-? signaling.
Breast Neoplasms
The kinesin Eg5 inhibitor K858 induces apoptosis and reverses the malignant invasive phenotype in human glioblastoma cells.
Breast Neoplasms
The kinesin Eg5 inhibitor K858 induces apoptosis but also survivin-related chemoresistance in breast cancer cells.
Breast Neoplasms
The Role of CHK1 Varies with the Status of Oestrogen-receptor and Progesterone-receptor in the Targeted Therapy for Breast Cancer.
Breast Neoplasms
The role of Kif4A in doxorubicin-induced apoptosis in breast cancer cells.
Breast Neoplasms
ZNF367-induced transcriptional activation of KIF15 accelerates the progression of breast cancer.
Carcinogenesis
A role for kinesin-1 subunits KIF5B/KLC1 in regulating epithelial mesenchymal plasticity in breast tumorigenesis.
Carcinogenesis
Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women.
Carcinogenesis
An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma.
Carcinogenesis
Bioinformatic analysis identifies potentially key differentially expressed genes in oncogenesis and progression of clear cell renal cell carcinoma.
Carcinogenesis
Clinicopathological Significance and Antitumor Effect of MPHOSPH1 in Testicular Germ Cell Tumor.
Carcinogenesis
Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.
Carcinogenesis
Down-regulation of KIF2A inhibits gastric cancer cell invasion via suppressing MT1-MMP.
Carcinogenesis
Elevated expression of KIF18A enhances cell proliferation and predicts poor survival in human clear cell renal carcinoma.
Carcinogenesis
Expression of KIF18A Is Associated with Increased Tumor Stage and Cell Proliferation in Prostate Cancer.
Carcinogenesis
High expression of KIF3A is a potential new parameter for the diagnosis and prognosis of breast cancer.
Carcinogenesis
High kinesin family member 18A expression correlates with poor prognosis in primary lung adenocarcinoma.
Carcinogenesis
Identification of therapeutic targets and mechanisms of tumorigenesis in non-small cell lung cancer using multiple-microarray analysis.
Carcinogenesis
Identifying common prognostic factors in genomic cancer studies: a novel index for censored outcomes.
Carcinogenesis
Increased KIF15 Expression Predicts a Poor Prognosis in Patients with Lung Adenocarcinoma.
Carcinogenesis
Integrated analysis reveals candidate mRNA and their potential roles in uterine leiomyomas.
Carcinogenesis
Involvement of kinesin family member 2C/mitotic centromere-associated kinesin overexpression in mammary carcinogenesis.
Carcinogenesis
KIF11 as a potential cancer prognostic marker promotes tumorigenesis in children with Wilms tumor.
Carcinogenesis
KIF11 is upregulated in colorectal cancer and silencing of it impairs tumor growth and sensitizes colorectal cancer cells to oxaliplatin via p53/GSK3? signaling.
Carcinogenesis
KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer.
Carcinogenesis
KIF15 promotes pancreatic cancer proliferation via the MEK-ERK signalling pathway.
Carcinogenesis
KIF20A silence inhibits the migration, invasion and proliferation of non-small cell lung cancer and regulates the JNK pathway.
Carcinogenesis
KIF2A Overexpression and Its Association with Clinicopathologic Characteristics and Poor Prognoses in Patients with Gastric Cancer.
Carcinogenesis
KIF2A overexpression and its association with clinicopathologic characteristics and unfavorable prognosis in colorectal cancer.
Carcinogenesis
KIF3A binds to ?-arrestin for suppressing Wnt/?-catenin signalling independently of primary cilia in lung cancer.
Carcinogenesis
Kif4A mediate the accumulation and reeducation of THP-1 derived macrophages via regulation of CCL2-CCR2 expression in crosstalking with OSCC.
Carcinogenesis
Kinesin 12 (KIF15) contributes to the development and tumorigenicity of prostate cancer.
Carcinogenesis
Kinesin family member 3A inhibits the carcinogenesis of non-small cell lung cancer and prolongs survival.
Carcinogenesis
Kinesin family member KIF18A is a critical cellular factor that regulates the differentiation and activation of dendritic cells.
Carcinogenesis
Kinesin motor protein KIFC1 is a target protein of miR-338-3p and associated with poor prognosis and progression of renal cell carcinoma.
Carcinogenesis
Micronuclei in Kif18a mutant mice form stable micronuclear envelopes and do not promote tumorigenesis.
Carcinogenesis
MiR-127-3p targets KIF3B to inhibit the development of oral squamous cell carcinoma.
Carcinogenesis
Molecular characterization of a KIF3A-like kinesin gene in the testis of the Chinese fire-bellied newt Cynops orientalis.
Carcinogenesis
Novel intergenic KIF5B-MET fusion variant in a patient with gastric cancer: A case report.
Carcinogenesis
Overexpression of KIF20A confers malignant phenotype of lung adenocarcinoma by promoting cell proliferation and inhibiting apoptosis.
Carcinogenesis
Parkin regulates Eg5 expression by Hsp70 ubiquitination-dependent inactivation of c-Jun NH2-terminal kinase.
Carcinogenesis
Roles of kinesin superfamily proteins in colorectal cancer carcinogenesis (Review).
Carcinogenesis
Screening and Identification of Potential Biomarkers in Hepatitis B Virus-Related Hepatocellular Carcinoma by Bioinformatics Analysis.
Carcinogenesis
Silencing of KIF18B restricts proliferation and invasion and enhances the chemosensitivity of breast cancer via modulating Akt/GSK-3?/?-catenin pathway.
Carcinogenesis
Stable knockdown of Kif5b in MDCK cells leads to epithelial-mesenchymal transition.
Carcinogenesis
Suppression of KIF3A inhibits triple negative breast cancer growth and metastasis by repressing Rb-E2F signaling and epithelial-mesenchymal transition.
Carcinogenesis
Suppression of KIF3B Expression Inhibits Human Hepatocellular Carcinoma Proliferation.
Carcinogenesis
Targeted deletion of Kif18a protects from colitis-associated colorectal (CAC) tumors in mice through impairing Akt phosphorylation.
Carcinogenesis
Targeting protein for Xenopus kinesin-like protein 2 knockdown enhances radiation sensitivity of human lung squamous carcinoma cell.
Carcinogenesis
The role of kinesin family proteins in tumorigenesis and progression: potential biomarkers and molecular targets for cancer therapy.
Carcinogenesis
TPX2 level correlates with cholangiocarcinoma cell proliferation, apoptosis, and EMT.
Carcinogenesis
[Expression of KIF18A in gastric cancer and its association with prognosis].
Carcinoma
A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian adenocarcinomas.
Carcinoma
A five-gene signature predicts overall survival of patients with papillary renal cell carcinoma.
Carcinoma
ALK rearranged renal cell carcinoma (ALK-RCC): a multi-institutional study of twelve cases with identification of novel partner genes CLIP1, KIF5B and KIAA1217.
Carcinoma
AURKA mRNA expression is an independent predictor of poor prognosis in patients with non-small cell lung cancer.
Carcinoma
Bioinformatics Analysis of KIF1A Expression and Gene Regulation Network in Ovarian Carcinoma.
Carcinoma
Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells.
Carcinoma
Down-regulation of KIF2A inhibits gastric cancer cell invasion via suppressing MT1-MMP.
Carcinoma
Elevated expression of KIF18A enhances cell proliferation and predicts poor survival in human clear cell renal carcinoma.
Carcinoma
Expression of Kif5b protein is significantly associated with the progression, recurrence and prognosis of oral squamous cell carcinoma.
Carcinoma
Expression of microtubule-associated protein TPX2 in human gastric carcinoma and its prognostic significance.
Carcinoma
High KIF2A expression promotes proliferation, migration and predicts poor prognosis in lung adenocarcinoma.
Carcinoma
High kinesin family member 11 expression predicts poor prognosis in patients with clear cell renal cell carcinoma.
Carcinoma
Immune responses against tumour-associated antigen-derived cytotoxic T lymphocyte epitopes in cholangiocarcinoma patients.
Carcinoma
Increased KIF15 Expression Predicts a Poor Prognosis in Patients with Lung Adenocarcinoma.
Carcinoma
KIF-2C expression is correlated with poor prognosis of operable esophageal squamous cell carcinoma male patients.
Carcinoma
KIF4A enhanced cell proliferation and migration via Hippo signaling and predicted a poor prognosis in esophageal squamous cell carcinoma.
Carcinoma
KIF4A Promotes Clear Cell Renal Cell Carcinoma (ccRCC) Proliferation in vitro and in vivo.
Carcinoma
Kinesin family member 11 is a potential therapeutic target and is suppressed by microRNA-30a in breast cancer.
Carcinoma
Kinesin family member 4A: a potential predictor for progression of human oral cancer.
Carcinoma
Kinesin motor protein KIFC1 is a target protein of miR-338-3p and associated with poor prognosis and progression of renal cell carcinoma.
Carcinoma
Metal-proteinase ADAM12, kinesin 14 and checkpoint suppressor 1 as new molecular markers of laryngeal carcinoma.
Carcinoma
MiR-127-3p targets KIF3B to inhibit the development of oral squamous cell carcinoma.
Carcinoma
Overexpression of KIFC1 and its association with spheroid formation in esophageal squamous cell carcinoma.
Carcinoma
Preliminary study on the clinical significance of kinesin Kif18a in nonsmall cell lung cancer: An analysis of 100 cases.
Carcinoma
Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis.
Carcinoma
Prognostic and clinicopathological significance of kinesin family member C1 in various cancers: A meta-analysis.
Carcinoma
Relation between the expression of mitotic centromere-associated kinesin and the progression of squamous cell carcinoma of the tongue.
Carcinoma
The kinesin motor protein KIF4A as a potential therapeutic target in renal cell carcinoma.
Carcinoma
The Overexpression of Kinesin Superfamily Protein 2A (KIF2A) was Associated with the Proliferation and Prognosis of Esophageal Squamous Cell Carcinoma.
Carcinoma
YAP/TEAD4-induced KIF4A contributes to the progression and worse prognosis of esophageal squamous cell carcinoma.
Carcinoma, Basal Cell
Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis.
Carcinoma, Ductal
Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women.
Carcinoma, Hepatocellular
A genetic variant at KIF1B predicts clinical outcome of HBV-related hepatocellular carcinoma in Chinese.
Carcinoma, Hepatocellular
ASPM combined with KIF11 promotes the malignant progression of hepatocellular carcinoma via the Wnt/?-catenin signaling pathway.
Carcinoma, Hepatocellular
Association between KIF1B (rs17401966) polymorphism and hepatocellular carcinoma susceptibility: a meta-analysis.
Carcinoma, Hepatocellular
Association between KIF1B rs17401966 genetic polymorphism and hepatocellular carcinoma susceptibility: an updated meta-analysis.
Carcinoma, Hepatocellular
Association between KIF1B rs17401966 polymorphism and hepatocellular carcinoma risk: a meta-analysis involving 17,210 subjects.
Carcinoma, Hepatocellular
Correction to: KIFC1 is activated by TCF-4 and promotes hepatocellular carcinoma pathogenesis by regulating HMGA1 transcriptional activity.
Carcinoma, Hepatocellular
Downregulation of KIF1B mRNA in hepatocellular carcinoma tissues correlates with poor prognosis.
Carcinoma, Hepatocellular
Effects of interactions between environmental factors and KIF1B genetic variants on the risk of hepatocellular carcinoma in a Chinese cohort.
Carcinoma, Hepatocellular
FOXM1 promotes hepatocellular carcinoma progression by regulating KIF4A expression.
Carcinoma, Hepatocellular
Genetic polymorphism of the kinesin-like protein KIF1B gene and the risk of hepatocellular carcinoma.
Carcinoma, Hepatocellular
GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers.
Carcinoma, Hepatocellular
HBV-Related Hepatocellular Carcinoma Susceptibility Gene KIF1B Is Not Associated with Development of Chronic Hepatitis B.
Carcinoma, Hepatocellular
High KIF18A expression correlates with unfavorable prognosis in primary hepatocellular carcinoma.
Carcinoma, Hepatocellular
Host genetic variants influencing the clinical course of hepatitis B virus infection.
Carcinoma, Hepatocellular
Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer.
Carcinoma, Hepatocellular
Increased KIF21B expression is a potential prognostic biomarker in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Inhibition of kinesin family member 20B sensitizes hepatocellular carcinoma cell to microtubule-targeting agents by blocking cytokinesis.
Carcinoma, Hepatocellular
KIF11 Promotes Proliferation of Hepatocellular Carcinoma among Patients with Liver Cancers.
Carcinoma, Hepatocellular
KIF15 Expression in Tumor-associated Monocytes Is a Prognostic Biomarker in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
KIF15 Promotes Proliferation and Growth of Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
KIF18B promotes hepatocellular carcinoma progression through activating Wnt/?-catenin-signaling pathway.
Carcinoma, Hepatocellular
KIF20A mRNA and its product MKlp2 are increased during hepatocyte proliferation and hepatocarcinogenesis.
Carcinoma, Hepatocellular
KIF2C promotes the proliferation of hepatocellular carcinoma cells in vitro and in vivo.
Carcinoma, Hepatocellular
KIF2C: a novel link between Wnt/?-catenin and mTORC1 signaling in the pathogenesis of hepatocellular carcinoma.
Carcinoma, Hepatocellular
KIFC1 is activated by TCF-4 and promotes hepatocellular carcinoma pathogenesis by regulating HMGA1 transcriptional activity.
Carcinoma, Hepatocellular
KIFC1 promotes the proliferation of hepatocellular carcinoma in vitro and in vivo.
Carcinoma, Hepatocellular
KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling.
Carcinoma, Hepatocellular
KIFC1, a novel potential prognostic factor and therapeutic target in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Kinesin 12 (KIF15) contributes to the development and tumorigenicity of prostate cancer.
Carcinoma, Hepatocellular
Kinesin family member 15 promotes cancer stem cell phenotype and malignancy via reactive oxygen species imbalance in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Kinesin family member 2C aggravates the progression of hepatocellular carcinoma and interacts with competing endogenous RNA.
Carcinoma, Hepatocellular
Kinesin family member 2C promotes hepatocellular carcinoma growth and metastasis via activating MEK/ERK pathway.
Carcinoma, Hepatocellular
Kinesin family members KIF2C/4A/10/11/14/18B/20A/23 predict poor prognosis and promote cell proliferation in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Kinesin superfamily protein expression and its association with progression and prognosis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Meta-analysis of the correlation between the rs17401966 polymorphism in kinesin family member 1B and susceptibility to hepatitis B virus related hepatocellular carcinoma.
Carcinoma, Hepatocellular
miR-450b-5p loss mediated KIF26B activation promoted hepatocellular carcinoma progression by activating PI3K/AKT pathway.
Carcinoma, Hepatocellular
Overexpression of CDCA5, KIF4A, TPX2, and FOXM1 Coregulated Cell Cycle and Promoted Hepatocellular Carcinoma Development.
Carcinoma, Hepatocellular
Prognostic and clinicopathological significance of kinesin family member C1 in various cancers: A meta-analysis.
Carcinoma, Hepatocellular
Replication of genome wide association studies on hepatocellular carcinoma susceptibility loci in a Chinese population.
Carcinoma, Hepatocellular
Role of single nucleotide polymorphisms of KIF1B gene in HBV-associated viral hepatitis.
Carcinoma, Hepatocellular
Silencing of KIF14 interferes with cell cycle progression and cytokinesis by blocking the p27(Kip1) ubiquitination pathway in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Suppression of KIF3B Expression Inhibits Human Hepatocellular Carcinoma Proliferation.
Carcinoma, Hepatocellular
The clinical value of kinesin superfamily protein 2A in hepatocellular carcinoma.
Carcinoma, Hepatocellular
The KIF1B (rs17401966) Single Nucleotide Polymorphism is not Associated with the Development of HBV-related Hepatocellular Carcinoma in Thai Patients.
Carcinoma, Hepatocellular
The role of kinesin KIF18A in the invasion and metastasis of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Upregulate KIF4A Enhances Proliferation, Invasion of Hepatocellular Carcinoma and Indicates poor prognosis Across Human Cancer Types.
Carcinoma, Hepatocellular
Upregulation of kinesin family member 4A enhanced cell proliferation via activation of Akt signaling and predicted a poor prognosis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
[The relationship between the KIF1B (rs17401966) single nucleotide polymorphism and the genetic susceptibility to Hepatocellular carcinoma].
Carcinoma, Intraductal, Noninfiltrating
Age-specific gene expression signatures for breast tumors and cross-species conserved potential cancer progression markers in young women.
Carcinoma, Non-Small-Cell Lung
Activation of KIF4A as a prognostic biomarker and therapeutic target for lung cancer.
Carcinoma, Non-Small-Cell Lung
AURKA mRNA expression is an independent predictor of poor prognosis in patients with non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
AURKA, DLGAP5, TPX2, KIF11 and CKAP5: Five specific mitosis-associated genes correlate with poor prognosis for non-small cell lung cancer patients.
Carcinoma, Non-Small-Cell Lung
Expressions of Kif2c and Ki-67 in non-small cell lung cancer and their relationship with invasion and metastasis.
Carcinoma, Non-Small-Cell Lung
High KIF11 expression is associated with poor outcome of NSCLC.
Carcinoma, Non-Small-Cell Lung
KIF2C exerts an oncogenic role in nonsmall cell lung cancer and is negatively regulated by miR-325-3p.
Carcinoma, Non-Small-Cell Lung
KIF5B/RET fusion gene in surgically-treated adenocarcinoma of the lung.
Carcinoma, Non-Small-Cell Lung
KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling.
Carcinoma, Non-Small-Cell Lung
Kinesin family member 2A high expression correlates with advanced tumor stages and worse prognosis in non-small cell lung cancer patients.
Carcinoma, Non-Small-Cell Lung
Kinesin family member 2A promotes cancer cell viability, mobility, stemness, and chemoresistance to cisplatin by activating the PI3K/AKT/VEGF signaling pathway in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Kinesin family member 3A inhibits the carcinogenesis of non-small cell lung cancer and prolongs survival.
Carcinoma, Non-Small-Cell Lung
Kinesin family member 3C (KIF3C) is a novel non-small cell lung cancer (NSCLC) oncogene whose expression is modulated by microRNA-150-5p (miR-150-5p) and microRNA-186-3p (miR-186-3p).
Carcinoma, Non-Small-Cell Lung
Kinesin superfamily protein 21B acts as an oncogene in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Novel genetic variants in KIF16B and NEDD4L in the endosome-related genes are associated with nonsmall cell lung cancer survival.
Carcinoma, Non-Small-Cell Lung
Preliminary study on the clinical significance of kinesin Kif18a in nonsmall cell lung cancer: An analysis of 100 cases.
Carcinoma, Non-Small-Cell Lung
Prognostic and clinicopathological significance of kinesin family member C1 in various cancers: A meta-analysis.
Carcinoma, Non-Small-Cell Lung
The overexpression of KIFC1 was associated with the proliferation and prognosis of non-small cell lung cancer.
Carcinoma, Ovarian Epithelial
A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian adenocarcinomas.
Carcinoma, Ovarian Epithelial
Low expression of KIF7 indicates poor prognosis in epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Overexpression of kinesin family member 20A is associated with unfavorable clinical outcome and tumor progression in epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Polymorphisms in the kinesin-like factor 1 B gene and risk of epithelial ovarian cancer in Eastern Chinese women.
Carcinoma, Renal Cell
A five-gene signature predicts overall survival of patients with papillary renal cell carcinoma.
Carcinoma, Renal Cell
ALK rearranged renal cell carcinoma (ALK-RCC): a multi-institutional study of twelve cases with identification of novel partner genes CLIP1, KIF5B and KIAA1217.
Carcinoma, Renal Cell
DAB2IP modulates primary cilia formation associated with renal tumorigenesis.
Carcinoma, Renal Cell
Elevated expression of KIF18A enhances cell proliferation and predicts poor survival in human clear cell renal carcinoma.
Carcinoma, Renal Cell
High kinesin family member 11 expression predicts poor prognosis in patients with clear cell renal cell carcinoma.
Carcinoma, Renal Cell
KIF4A Promotes Clear Cell Renal Cell Carcinoma (ccRCC) Proliferation in vitro and in vivo.
Carcinoma, Renal Cell
Kinesin motor protein KIFC1 is a target protein of miR-338-3p and associated with poor prognosis and progression of renal cell carcinoma.
Carcinoma, Renal Cell
The kinesin motor protein KIF4A as a potential therapeutic target in renal cell carcinoma.
Carcinoma, Squamous Cell
Down-regulation of KIF2A inhibits gastric cancer cell invasion via suppressing MT1-MMP.
Carcinoma, Squamous Cell
High KIF2A expression promotes proliferation, migration and predicts poor prognosis in lung adenocarcinoma.
Carcinoma, Squamous Cell
Immune responses against tumour-associated antigen-derived cytotoxic T lymphocyte epitopes in cholangiocarcinoma patients.
Carcinoma, Squamous Cell
Increased KIF15 Expression Predicts a Poor Prognosis in Patients with Lung Adenocarcinoma.
Carcinoma, Squamous Cell
Preliminary study on the clinical significance of kinesin Kif18a in nonsmall cell lung cancer: An analysis of 100 cases.
Carcinoma, Squamous Cell
Relation between the expression of mitotic centromere-associated kinesin and the progression of squamous cell carcinoma of the tongue.
Carcinoma, Squamous Cell
Targeting protein for Xenopus kinesin-like protein 2 knockdown enhances radiation sensitivity of human lung squamous carcinoma cell.
Cardiomegaly
Hypertrophy induced KIF5B controls mitochondrial localization and function in neonatal rat cardiomyocytes.
Cataract
Association of a rare haplotype in Kinesin light chain 1 gene with age-related cataract in a han chinese population.
Cataract
The link between apolipoprotein E, presenilin 1, and kinesin light chain 1 gene polymorphisms and age-related cortical cataracts in the Chinese population.
Cataract
Variability in the kinesin light chain 1 gene may influence risk of age-related cataract.
Cerebellar Ataxia
A novel KIF5A gene variant causes spastic paraplegia and cerebellar ataxia.
Cerebral Hemorrhage
Neuroprotection Exerted by Netrin-1 and Kinesin Motor KIF1A in Secondary Brain Injury following Experimental Intracerebral Hemorrhage in Rats.
Charcot-Marie-Tooth Disease
A Novel Mutation in the Stalk Domain of KIF5A Causes a Slowly Progressive Atypical Motor Syndrome.
Charcot-Marie-Tooth Disease
Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins.
Charcot-Marie-Tooth Disease
Biochemical and molecular characterization of diseases linked to motor proteins.
Charcot-Marie-Tooth Disease
Charcot-Marie-Tooth disease and related neuropathies: mutation distribution and genotype-phenotype correlation.
Charcot-Marie-Tooth Disease
Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta.
Charcot-Marie-Tooth Disease
Extended phenotypic spectrum of KIF5A mutations: From spastic paraplegia to axonal neuropathy.
Charcot-Marie-Tooth Disease
New structural variations responsible for Charcot-Marie-Tooth disease: The first two large KIF5A deletions detected by CovCopCan software.
Charcot-Marie-Tooth Disease
The kinesin superfamily protein Rab6KIFL is not involved in the pathophysiology of Charcot-Marie-Tooth disease type 4C.
Charcot-Marie-Tooth Disease
Unique function of Kinesin Kif5A in localization of mitochondria in axons.
Charcot-Marie-Tooth Disease
[Intracellular transport proteins: classification, structure and function of kinesins].
Chickenpox
Pseudorabies Virus Infection Accelerates Degradation of the Kinesin-3 Motor KIF1A.
Cholangiocarcinoma
Identification of key genes associated with the progression of intrahepatic cholangiocarcinoma using weighted gene co-expression network analysis.
Cholangiocarcinoma
Proteomic analysis to identify plasma orosomucoid 2 and kinesin 18A as potential biomarkers of cholangiocarcinoma.
Cholangiocarcinoma
TPX2 level correlates with cholangiocarcinoma cell proliferation, apoptosis, and EMT.
Ciliopathies
A ciliopathy with hydrocephalus, isolated craniosynostosis, hypertelorism, and clefting caused by deletion of Kif3a.
Ciliopathies
KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms.
Ciliopathies
Loss of function mutations in KIF14 cause severe microcephaly and kidney development defects in humans and zebrafish.
Ciliopathies
Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy.
Ciliopathies
Novel Insights Into the Phenotypical Spectrum of KIF11-Associated Retinopathy, Including a New Form of Retinal Ciliopathy.
Ciliopathies
Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function.
Cleft Palate
A ciliopathy with hydrocephalus, isolated craniosynostosis, hypertelorism, and clefting caused by deletion of Kif3a.
Colitis
Discovery and Validation of Methylation Biomarkers for Ulcerative Colitis Associated Neoplasia.
Colonic Diseases
Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway.
Colonic Neoplasms
A unique gene having homology with the kinesin family member 18A encodes a tumour-associated antigen recognised by cytotoxic T lymphocytes from HLA-A2+ colon cancer patients.
Colonic Neoplasms
Bioinformatics Analysis of Prognostic miRNA Signature and Potential Critical Genes in Colon Cancer.
Colonic Neoplasms
Downregulated KIF3B Induced by miR-605-3p Inhibits the Progression of Colon Cancer via Inactivating Wnt/?-Catenin.
Colonic Neoplasms
Kinesin Superfamily Member 18B (KIF18B) Promotes Cell Proliferation in Colon Adenocarcinoma.
Colorectal Neoplasms
A survey of methylated candidate tumor suppressor genes in nasopharyngeal carcinoma.
Colorectal Neoplasms
Aberrant KIF23 expression is associated with adverse clinical outcome and promotes cellular malignant behavior through the Wnt/?-catenin signaling pathway in Colorectal Cancer.
Colorectal Neoplasms
Chromosomally unstable tumor cells specifically require KIF18A for proliferation.
Colorectal Neoplasms
Correlation of gene methylation in surgical margin imprints with locoregional recurrence in head and neck squamous cell carcinoma.
Colorectal Neoplasms
Down-regulation of KIF2A inhibits gastric cancer cell invasion via suppressing MT1-MMP.
Colorectal Neoplasms
Elevated kinesin family member 26B is a prognostic biomarker and a potential therapeutic target for colorectal cancer.
Colorectal Neoplasms
Enhanced expression of KIF4A in colorectal cancer is associated with lymph node metastasis.
Colorectal Neoplasms
Evidence of Colorectal Cancer-Associated Mutation in MCAK: A Computational Report.
Colorectal Neoplasms
High kinesin family member 18A expression correlates with poor prognosis in primary lung adenocarcinoma.
Colorectal Neoplasms
KIF11 Is Required for Spheroid Formation by Oesophageal and Colorectal Cancer Cells.
Colorectal Neoplasms
KIF11 is upregulated in colorectal cancer and silencing of it impairs tumor growth and sensitizes colorectal cancer cells to oxaliplatin via p53/GSK3? signaling.
Colorectal Neoplasms
KIF14 promotes cell proliferation via activation of Akt and is directly targeted by miR-200c in colorectal cancer.
Colorectal Neoplasms
KIF4A facilitates cell proliferation via induction of p21-mediated cell cycle progression and promotes metastasis in colorectal cancer.
Colorectal Neoplasms
KIFC1 regulates ZWINT to promote tumor progression and spheroid formation in colorectal cancer.
Colorectal Neoplasms
Kinesin 18A expression clinical relevance to colorectal cancer progression.
Colorectal Neoplasms
LEF-AS1 participates in occurrence of colorectal cancer through adsorbing miR-505 and promoting KIF3B expression.
Colorectal Neoplasms
Mitotic centromere-associated kinesin is a novel marker for prognosis and lymph node metastasis in colorectal cancer.
Colorectal Neoplasms
Pseudopod-associated protein KIF20B promotes Gli1-induced epithelial-mesenchymal transition modulated by pseudopodial actin dynamic in human colorectal cancer.
Colorectal Neoplasms
Roles of kinesin superfamily proteins in colorectal cancer carcinogenesis (Review).
Colorectal Neoplasms
Somatic frameshift mutations of cancer-related genes KIF3C and BARD1 in colorectal cancers.
Colorectal Neoplasms
Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma.
Colorectal Neoplasms
[Establishment of a targeting protein for Xenopus kinesin-like protein 2 C' terminal SBP-3 x Flag tagged HCT 116 colorectal cancer cell model].
Congenital Abnormalities
'Kinesinopathies': emerging role of the kinesin family member genes in birth defects.
Contracture
Mobility Characteristics of Children with Spastic Paraplegia Due to a Mutation in the KIF1A Gene.
Coronary Artery Disease
Investigation of KIF6 Trp719Arg in a Case-Control Study of Coronary Artery Disease in Western Indians.
Coronary Artery Disease
Kinesin family member 6 variant Trp719Arg does not associate with angiographically defined coronary artery disease in the Ottawa Heart Genomics Study.
Coronary Artery Disease
Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies.
Coronary Disease
A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study.
Coronary Disease
Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials.
Coronary Disease
Impact of KIF6 Polymorphism rs20455 on Coronary Heart Disease Risk and Effectiveness of Statin Therapy in 100 Patients from Southern Iran.
Coronary Disease
Survival bias and drug interaction can attenuate cross-sectional case-control comparisons of genes with health outcomes. An example of the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism versus coronary heart disease.
Craniosynostoses
A ciliopathy with hydrocephalus, isolated craniosynostosis, hypertelorism, and clefting caused by deletion of Kif3a.
Cysts
Abnormal photoreceptor outer segment development and early retinal degeneration in kif3a mutant zebrafish.
Cysts
Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia.
Cysts
Combined deletion of Vhl, Trp53 and Kif3a causes cystic and neoplastic renal lesions.
Cysts
Loss of Glis2/NPHP7 causes kidney epithelial cell senescence and suppresses cyst growth in the Kif3a mouse model of cystic kidney disease.
Cysts
Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis.
Cysts
Primary cilia of inv/inv mouse renal epithelial cells sense physiological fluid flow: bending of primary cilia and Ca2+ influx.
Deafness
A novel KIF5A mutation in an Italian family marked by spastic paraparesis and congenital deafness.
Deglutition Disorders
KIF5A mutations cause an infantile onset phenotype including severe myoclonus with evidence of mitochondrial dysfunction.
Dehydration
Proteome Analysis of Dormancy-Released Seeds of Fraxinus mandshurica Rupr. in Response to Re-Dehydration under Different Conditions.
Dehydration
Role of the ERK signaling pathway in regulating vasopressin secretion in dehydrated rats.
Dementia
Tau proteins harboring neurodegeneration-linked mutations impair kinesin translocation in vitro.
Demyelinating Diseases
Sarcotubular Myopathy Due to Novel TRIM32 Mutation in Association with Multiple Sclerosis.
Dent Disease
CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease.
Dermatitis, Atopic
Association Of Kif3a, But Not Ovol1 And Actl9, With Atopic Eczema In Italian Patients.
Dermatitis, Atopic
Correlation of KIF3A and OVOL1, but not ACTL9, with atopic dermatitis in Chinese pediatric patients.
Dermatitis, Atopic
Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk.
Dermatitis, Contact
Machine-learning-driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis.
Diabetes Mellitus, Type 1
Diabetes induces changes in KIF1A, KIF5B and dynein distribution in the rat retina: implications for axonal transport.
Diabetes Mellitus, Type 2
Genetic variants of IDE-KIF11-HHEX at 10q23.33 associated with type 2 diabetes risk: a fine-mapping study in Chinese population.
Diabetes Mellitus, Type 2
The Effects of Combined Exercise Training (Resistance-Aerobic) on Serum Kinesin and Physical Function in Type 2 Diabetes Patients with Diabetic Peripheral Neuropathy (Randomized Controlled Trials).
Diabetic Cardiomyopathies
Mitochondrial Arrest on the Microtubule Highway-A Feature of Heart Failure and Diabetic Cardiomyopathy?
DiGeorge Syndrome
A Novel Mutation of KIF11 in a Child with 22q11.2 Deletion Syndrome Associated with MCLMR.
Digestive System Neoplasms
Clinical value of Xenopus kinesin-like protein 2 as a prognostic marker in patients with digestive system cancers: a systematic review and meta-analysis.
Down Syndrome
Altered expression of KIF17, a kinesin motor protein associated with NR2B trafficking, may mediate learning deficits in a Down syndrome mouse model.
Drug Resistant Epilepsy
RNA-seq analysis of hippocampal tissues reveals novel candidate genes for drug refractory epilepsy in patients with MTLE-HS.
Dwarfism
Brittle Culm12, a dual-targeting Kinesin-4 protein, controls cell cycle progression and wall properties in rice.
Dwarfism
Mutation of Rice BC12/GDD1, Which Encodes a Kinesin-Like Protein That Binds to a GA Biosynthesis Gene Promoter, Leads to Dwarfism with Impaired Cell Elongation.
Eczema
Identification of two early life eczema and non-eczema phenotypes with high risk for asthma development.
Eczema
KIF3A genetic variation is associated with pediatric asthma in the presence of eczema independent of allergic rhinitis.
Endometrial Neoplasms
Identification of molecular markers and signaling pathway in endometrial cancer in Hong Kong Chinese women by genome-wide gene expression profiling.
Endometrial Neoplasms
Kinesin Family Member C1 (KIFC1) Accelerates Proliferation and Invasion of Endometrial Cancer Cells Through Modulating the PI3K/AKT Signaling Pathway.
Endometrial Neoplasms
Macrophage ER? promoted invasion of endometrial cancer cell by mTOR/KIF5B -mediated epithelial to mesenchymal transition.
Endometrial Neoplasms
MiR-29a-5p inhibits proliferation and invasion and induces apoptosis in endometrial carcinoma via targeting TPX2.
Endometrial Neoplasms
STAT1-induced upregulation of lncRNA LINC01123 predicts poor prognosis and promotes the progression of endometrial cancer through miR-516b/KIF4A.
Epilepsy
A Novel de novo KIF1A Mutation in a Patient with Autism, Hyperactivity, Epilepsy, Sensory Disturbance, and Spastic Paraplegia.
Epilepsy
A Rare KIF1A Missense Mutation Enhances Synaptic Function and Increases Seizure Activity.
Epilepsy
Challenges in the clinical interpretation of small de novo copy number variants in neurodevelopmental disorders.
Epilepsy
De novo mutations in the motor domain of KIF1A cause cognitive impairment, spastic paraparesis, axonal neuropathy, and cerebellar atrophy.
Epilepsy
Interaction of different proteins with GABAA receptor and their modulatory effect on inhibitory neural transmission leads to epilepsy.
Epilepsy
Molecular motor KIF5A is essential for GABA(A) receptor transport, and KIF5A deletion causes epilepsy.
Epilepsy
Mutations of KIF5C cause a neurodevelopmental disorder of infantile-onset epilepsy, absent language, and distinctive malformations of cortical development.
Epilepsy
Phenotype description in KIF5C gene hot-spot mutations responsible for malformations of cortical development (MCD).
Epilepsy
Preliminary report for Epilepsia Open A case of West syndrome with severe global developmental delay and confirmed KIF5A gene variant.
Epilepsy
Variants in KIF2A cause broad clinical presentation; the computational structural analysis of a novel variant in a patient with a cortical dysplasia, complex, with other brain malformations 3.
Epilepsy, Rolandic
Evaluation of candidate genes in a Chinese cohort of atypical Rolandic epilepsy.
Equine Infectious Anemia
A nuclear kinesin-like protein interacts with and stimulates the activity of the leucine-rich nuclear export signal of the human immunodeficiency virus type 1 rev protein.
Esophageal Neoplasms
KIF18A knockdown reduces proliferation, migration, invasion and enhances radiosensitivity of esophageal cancer.
Esophageal Neoplasms
MicroRNA-2053 involves in the progression of esophageal cancer by targeting KIF3C.
Esophageal Squamous Cell Carcinoma
KIF-2C expression is correlated with poor prognosis of operable esophageal squamous cell carcinoma male patients.
Esophageal Squamous Cell Carcinoma
KIF4A enhanced cell proliferation and migration via Hippo signaling and predicted a poor prognosis in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Overexpression of KIFC1 and its association with spheroid formation in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Prognostic and clinicopathological significance of kinesin family member C1 in various cancers: A meta-analysis.
Esophageal Squamous Cell Carcinoma
The Overexpression of Kinesin Superfamily Protein 2A (KIF2A) was Associated with the Proliferation and Prognosis of Esophageal Squamous Cell Carcinoma.
Esophageal Squamous Cell Carcinoma
YAP/TEAD4-induced KIF4A contributes to the progression and worse prognosis of esophageal squamous cell carcinoma.
Familial Exudative Vitreoretinopathies
A mouse model for Kinesin Family Member 11 (Kif11)-associated familial exudative vitreoretinopathy.
Familial Exudative Vitreoretinopathies
Detection and quantification of a KIF11 mosaicism in a subject presenting familial exudative vitreoretinopathy with microcephaly.
Familial Exudative Vitreoretinopathies
Genotype Phenotype Correlation and Variability in Microcephaly Associated With Chorioretinopathy or Familial Exudative Vitreoretinopathy.
Familial Exudative Vitreoretinopathies
Identification of novel KIF11 mutations in patients with familial exudative vitreoretinopathy and a phenotypic analysis.
Familial Exudative Vitreoretinopathies
KIF11 mutations are a common cause of autosomal dominant familial exudative vitreoretinopathy.
Familial Exudative Vitreoretinopathies
Mutations in LRP5,FZD4, TSPAN12, NDP, ZNF408, or KIF11 Genes Account for 38.7% of Chinese Patients With Familial Exudative Vitreoretinopathy.
Familial Exudative Vitreoretinopathies
Novel variants in familial exudative vitreoretinopathy patients with KIF11 mutations and the Genotype-Phenotype correlation.
Familial Exudative Vitreoretinopathies
Phenotypic overlap between familial exudative vitreoretinopathy and microcephaly, lymphedema, and chorioretinal dysplasia caused by KIF11 mutations.
Familial Exudative Vitreoretinopathies
Retinal Features of Family Members With Familial Exudative Vitreoretinopathy Caused By Mutations in KIF11 Gene.
Familial Exudative Vitreoretinopathies
Spectrum of Variants in 389 Chinese Probands With Familial Exudative Vitreoretinopathy.
Fanconi Anemia
Screening and Identification of Therapeutic Targets for Pulmonary Arterial Hypertension Through Microarray Technology.
Fasciculation
Kinesin-1-mediated axonal transport of CB1 receptors is required for cannabinoid-dependent axonal growth and guidance.
Fasciculation
Localized Phosphorylation of a Kinesin-1 Adaptor by a Capsid-Associated Kinase Regulates HIV-1 Motility and Uncoating.
Fasciculation
Structural analysis of intermolecular interactions in the kinesin adaptor complex fasciculation and elongation protein zeta 1/ short coiled-coil protein (FEZ1/SCOCO).
Fowlpox
Interaction of poxvirus intracellular mature virion proteins with the TPR domain of kinesin light chain in live infected cells revealed by two photon-induced Fluorescence Resonance Energy Transfer Fluorescence Lifetime Imaging Microscopy.
Frontotemporal Dementia
Mutation analysis of KIF5A in Chinese amyotrophic lateral sclerosis patients.
Frontotemporal Dementia
Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease.
Gait Disorders, Neurologic
Monoallelic KIF1A-related disorders: a multicenter cross sectional study and systematic literature review.
Gallbladder Neoplasms
KIF11 promotes cell proliferation via ERBB2/PI3K/AKT signaling pathway in gallbladder cancer.
Gastrointestinal Neoplasms
Prognostic and clinical value of Targeting protein for Xenopus kinesin-like protein 2 in patients with gastrointestinal tract cancers: A meta-analysis.
Genetic Diseases, Inborn
Identification, partial characterization, and genetic mapping of kinesin-like protein genes in mouse.
Glaucoma
The Effect of Adjuvant Dimethylenastron, a Mitotic Kinesin Eg5 Inhibitor, in Experimental Glaucoma Filtration Surgery.
Glioblastoma
An interphase pool of KIF11 localizes at the basal bodies of primary cilia and a reduction in KIF11 expression alters cilia dynamics.
Glioblastoma
Confocal investigation on colocalization between tubulin posttranslational modifications and associated proteins in rat C6 glioma cells.
Glioblastoma
Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.
Glioblastoma
Enhancing Brain Retention of a KIF11 Inhibitor Significantly Improves its Efficacy in a Mouse Model of Glioblastoma.
Glioblastoma
Further Investigation About Copy Number Variations and Methylation of AURKA, KIF4A, and NUSAP1 in Glioblastoma.
Glioblastoma
Identification of Driver Genes and Key Pathways of Glioblastoma Shows JNJ-7706621 as a Novel Antiglioblastoma Drug.
Glioblastoma
Identification of Potential Biomarkers in Glioblastoma through Bioinformatic Analysis and Evaluating Their Prognostic Value.
Glioblastoma
Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells.
Glioblastoma
Integrative analysis of KIF4A, 9, 18A, and 23 and their clinical significance in low-grade glioma and glioblastoma.
Glioblastoma
KIF11 inhibition for glioblastoma treatment: reason to hope or a struggle with the brain?
Glioblastoma
Kinesin Family Member C1 Increases Temozolomide Resistance of Glioblastoma Through Promoting DNA Damage Repair.
Glioblastoma
The kinesin Eg5 inhibitor K858 induces apoptosis and reverses the malignant invasive phenotype in human glioblastoma cells.
Glioblastoma
The Microarray Gene Profiling Analysis of Glioblastoma Cancer Cells Reveals Genes Affected by Fak Inhibitor Y15 and Combination of Y15 and Temozolomide.
Glioblastoma
The mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastoma.
Glioblastoma
Upregulation of KIF11 in TP53 Mutant Glioma Promotes Tumor Stemness and Drug Resistance.
Glioma
Effect of N-1 arylation of monastrol on kinesin Eg5 inhibition in glioma cell lines.
Glioma
HDAC6 Signaling at Primary Cilia Promotes Proliferation and Restricts Differentiation of Glioma Cells.
Glioma
Identification of KIF15 as a potential therapeutic target and prognostic factor for glioma.
Glioma
Integrative analysis of KIF4A, 9, 18A, and 23 and their clinical significance in low-grade glioma and glioblastoma.
Glioma
Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways.
Glioma
KIF1B promotes glioma migration and invasion via cell surface localization of MT1-MMP.
Glioma
KIF23 enhances cell proliferation in pancreatic ductal adenocarcinoma and is a potent therapeutic target.
Glioma
KIF23 is an independent prognostic biomarker in glioma, transcriptionally regulated by TCF-4.
Glioma
KIF3C is associated with favorable prognosis in glioma patients and may be regulated by PI3K/AKT/mTOR pathway.
Glioma
KIF3C Promotes Proliferation, Migration, and Invasion of Glioma Cells by Activating the PI3K/AKT Pathway and Inducing EMT.
Glioma
Kinesin family member 14 is a candidate prognostic marker for outcome of glioma patients.
Glioma
Kinesin family member 2C (KIF2C/MCAK) is a novel marker for prognosis in human gliomas.
Glioma
Kinesin superfamily protein-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in human leukocyte antigen-A24+ glioma patients.
Glioma
Knockdown of circHIPK3 Facilitates Temozolomide Sensitivity in Glioma by Regulating Cellular Behaviors Through miR-524-5p/KIF2A-Mediated PI3K/AKT Pathway.
Glioma
MicroRNA-1294 inhibits the proliferation and enhances the chemosensitivity of glioma to temozolomide via the direct targeting of TPX2.
Glioma
MicroRNA-424 inhibits cell migration, invasion and epithelial-mesenchymal transition in human glioma by targeting KIF23 and functions as a novel prognostic predictor.
Glioma
The mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastoma.
Glioma
Upregulation of KIF11 in TP53 Mutant Glioma Promotes Tumor Stemness and Drug Resistance.
Heart Defects, Congenital
Overexpression of Kif1A in the Developing Drosophila Heart Causes Valvar and Contractility Defects: Implications for Human Congenital Heart Disease.
Heart Diseases
Survival bias and drug interaction can attenuate cross-sectional case-control comparisons of genes with health outcomes. An example of the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism versus coronary heart disease.
Hematologic Neoplasms
Impaired angiogenesis and tumor development by inhibition of the mitotic kinesin Eg5.
Hepatitis
Role of single nucleotide polymorphisms of KIF1B gene in HBV-associated viral hepatitis.
Hepatitis B
A genetic variant at KIF1B predicts clinical outcome of HBV-related hepatocellular carcinoma in Chinese.
Hepatitis B
Association between KIF1B rs17401966 genetic polymorphism and hepatocellular carcinoma susceptibility: an updated meta-analysis.
Hepatitis B
GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers.
Hepatitis B
HBV-Related Hepatocellular Carcinoma Susceptibility Gene KIF1B Is Not Associated with Development of Chronic Hepatitis B.
Hepatitis B
Meta-analysis of the correlation between the rs17401966 polymorphism in kinesin family member 1B and susceptibility to hepatitis B virus related hepatocellular carcinoma.
Hepatitis B
Replication of genome wide association studies on hepatocellular carcinoma susceptibility loci in a Chinese population.
Hepatitis B
Role of single nucleotide polymorphisms of KIF1B gene in HBV-associated viral hepatitis.
Hepatitis B, Chronic
HBV-Related Hepatocellular Carcinoma Susceptibility Gene KIF1B Is Not Associated with Development of Chronic Hepatitis B.
Hepatitis C
PNPLA3 and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies and severity of underlying liver diseases.
Hepatitis C
Replication of genome wide association studies on hepatocellular carcinoma susceptibility loci in a Chinese population.
Hereditary Sensory and Autonomic Neuropathies
A de novo dominant mutation in KIF1A associated with axonal neuropathy, spasticity and autism spectrum disorder.
Hereditary Sensory and Autonomic Neuropathies
KIF1A variants are a frequent cause of autosomal dominant hereditary spastic paraplegia.
Hereditary Sensory and Autonomic Neuropathies
KIF1A, an Axonal Transporter of Synaptic Vesicles, Is Mutated in Hereditary Sensory and Autonomic Neuropathy Type 2.
Herpes Simplex
Association of the herpes simplex virus type 1 Us11 gene product with the cellular kinesin light-chain-related protein PAT1 results in the redistribution of both polypeptides.
Herpes Simplex
Centripetal transport of herpes simplex virus in human retinal pigment epithelial cells in vitro.
Herpes Simplex
Herpes Simplex Virus 1 US3 Phosphorylates Cellular KIF3A To Downregulate CD1d Expression.
Herpes Simplex
Herpes simplex virus tegument protein US11 interacts with conventional kinesin heavy chain.
Herpes Simplex
Herpes simplex virus type 2 membrane protein UL56 associates with the kinesin motor protein KIF1A.
Herpes Simplex
Kinesin-1 Proteins KIF5A, -5B, and -5C Promote Anterograde Transport of Herpes Simplex Virus Enveloped Virions in Axons.
Herpes Simplex
Pseudorabies Virus Infection Accelerates Degradation of the Kinesin-3 Motor KIF1A.
Herpes Simplex
The Basic Domain of Herpes Simplex Virus 1 pUS9 Recruits Kinesin-1 To Facilitate Egress from Neurons.
Herpes Zoster
Pseudorabies Virus Infection Accelerates Degradation of the Kinesin-3 Motor KIF1A.
Hirschsprung Disease
Quantitative Proteomics Reveals Association of Neuron Projection Development Genes ARF4, KIF5B, and RAB8A With Hirschsprung Disease.
Huntington Disease
Interrogating Emergent Transport Properties for Molecular Motor Ensembles: A Semi-analytical Approach.
Hydrocephalus
A ciliopathy with hydrocephalus, isolated craniosynostosis, hypertelorism, and clefting caused by deletion of Kif3a.
Hypercholesterolemia
Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C.
Hyperglycemia
Targeted Inactivation of Kinesin-1 in Pancreatic {beta}-Cells in vivo Leads to Insulin Secretory Deficiency.
Hypersensitivity
Altered expression of ubiquitous kinesin heavy chain results in resistance to etoposide and hypersensitivity to colchicine: mapping of the domain associated with drug response.
Hypersensitivity
KIF3A, a Cilia Structural Gene on Chromosome 5q31, and Its Polymorphisms Show an Association with Aspirin Hypersensitivity in Asthma.
Hypersensitivity
Kinesin Kif2C in regulation of DNA double strand break dynamics and repair.
Hypersensitivity
TORC1 kinase and the S-phase cyclin Clb5 collaborate to promote mitotic spindle assembly and DNA replication in S. cerevisiae.
Hypersensitivity
Tozasertib Attenuates Neuropathic Pain by Interfering with Aurora Kinase and KIF11 Mediated Nociception.
Hypertelorism
A ciliopathy with hydrocephalus, isolated craniosynostosis, hypertelorism, and clefting caused by deletion of Kif3a.
Hypertension
Gene-environmental effects behind leukoaraiosis: a silent genetic variant of the kinesin protein can be activated in a subject with poorly controlled long-lasting hypertension.
Hypopigmentation
Postzygotic inactivating mutation of KIF13A located at chromosome 6p22.3 in a patient with a novel mosaic neuroectodermal syndrome.
Hypothyroidism
Thyroid-specific inactivation of KIF3A alters TSH signaling pathway and leads to hypothyroidism.
Immune System Diseases
KIF3A, a Cilia Structural Gene on Chromosome 5q31, and Its Polymorphisms Show an Association with Aspirin Hypersensitivity in Asthma.
Infections
A Botrytis cinerea KLP-7 Kinesin acts as a Virulence Determinant during Plant Infection.
Infections
A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome.
Infections
Antigen Export Reduces Antigen Presentation and Limits T Cell Control of M. tuberculosis.
Infections
Axonopathy Is Associated with Complex Axonal Transport Defects in a Model of Multiple Sclerosis.
Infections
Comparison of Recombinant Proteins of Kinesin 39, Heat Shock Protein 70, Heat Shock Protein 83 and Glycoprotein 63 for Antibody Detection of Leishmania martiniquensis Infection.
Infections
Dynamic Dissection of Dynein and Kinesin-1 Cooperatively Mediated Intercellular Transport of Porcine Epidemic Diarrhea Coronavirus along Microtubule Using Single Virus Tracking.
Infections
Exploiting the kinesin-1 molecular motor to generate a virus membrane penetration site.
Infections
Functional characterisation and drug target validation of a mitotic kinesin-13 in Trypanosoma brucei.
Infections
Glycoproteins gE and gI Are Required for Efficient KIF1A-Dependent Anterograde Axonal Transport of Alphaherpesvirus Particles in Neurons.
Infections
High Transcriptional Activity and Diverse Functional Repertoires of Hundreds of Giant Viruses in a Coastal Marine System.
Infections
HIV-1 capsid exploitation of the host microtubule cytoskeleton during early infection.
Infections
HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus.
Infections
Involvement of microtubular network and its motors in productive endocytic trafficking of mouse polyomavirus.
Infections
KIF5B and Nup358 Cooperatively Mediate the Nuclear Import of HIV-1 during Infection.
Infections
Kinesin-1-mediated capsid disassembly and disruption of the nuclear pore complex promote virus infection.
Infections
Kinesin-3 mediates axonal sorting and directional transport of alphaherpesvirus particles in neurons.
Infections
Pseudorabies Virus Infection Accelerates Degradation of the Kinesin-3 Motor KIF1A.
Infections
Quantitative Mass Spectrometry Identifies Novel Host Binding Partners for Pathogenic Escherichia coli Type III Secretion System Effectors.
Infections
Rotavirus replication is correlated with S/G2 interphase arrest of the host cell cycle.
Infections
Salmonella exploits Arl8B-directed kinesin activity to promote endosome tubulation and cell-to-cell transfer.
Infections
Selective and ATP-competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus.
Infections
siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells.
Infections
Soluble N-ethylmaleimide-sensitive factor attachment protein receptors required during Trypanosoma cruzi parasitophorous vacuole development.
Infections
The Enterohemorrhagic Escherichia coli Effector EspW Triggers Actin Remodeling in a Rac1-Dependent Manner.
Infections
The Pseudomonas syringae Type III Effector HopG1 Induces Actin Remodeling to Promote Symptom Development and Susceptibility during Infection.
Infections
Tobacco mosaic virus movement protein functions as a structural microtubule-associated protein.
Infections
Trypanosoma musculi Infection in Mice Critically Relies on Mannose Receptor-Mediated Arginase Induction by a TbKHC1 Kinesin H Chain Homolog.
Infertility
Germinal Cell Aplasia in Kif18a Mutant Male Mice Due to Impaired Chromosome Congression and Dysregulated BubR1 and CENP-E.
Infertility
Protein Fingerprinting of Seminal Plasma Reveals Dysregulation of Exosome-Associated Proteins in Infertile Men with Unilateral Varicocele.
Inflammatory Bowel Diseases
Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway.
Inflammatory Bowel Diseases
Replication of KIF21B as a susceptibility locus for multiple sclerosis.
Influenza, Human
Selective and ATP-competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus.
Insulin Resistance
Adipose-specific deletion of Kif5b exacerbates obesity and insulin resistance in a mouse model of diet-induced obesity.
Insulin Resistance
Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity.
Insulinoma
The identification, purification, and characterization of a pancreatic beta-cell form of the microtubule adenosine triphosphatase kinesin.
Intellectual Disability
A mouse model for Kinesin Family Member 11 (Kif11)-associated familial exudative vitreoretinopathy.
Intellectual Disability
A Novel de novo KIF1A Mutation in a Patient with Autism, Hyperactivity, Epilepsy, Sensory Disturbance, and Spastic Paraplegia.
Intellectual Disability
A Novel Synergistic Association of Variants in PTRH2 and KIF1A Relates to a Syndrome of Hereditary Axonopathy, Outer Hair Cell Dysfunction, Intellectual Disability, Pancreatic Lipomatosis, Diabetes, Cerebellar Atrophy, and Vertebral Artery Hypoplasia.
Intellectual Disability
A Rare KIF1A Missense Mutation Enhances Synaptic Function and Increases Seizure Activity.
Intellectual Disability
Autosomal dominant transmission of complicated hereditary spastic paraplegia due to a dominant negative mutation of KIF1A, SPG30 gene.
Intellectual Disability
De novo KIF1A mutations cause intellectual deficit, cerebellar atrophy, lower limb spasticity and visual disturbance.
Intellectual Disability
Dendritic mRNA targeting of Jacob and N-methyl-d-aspartate-induced nuclear translocation after calpain-mediated proteolysis.
Intellectual Disability
Heterozygous KIF1A variants underlie a wide spectrum of neurodevelopmental and neurodegenerative disorders.
Intellectual Disability
Identification of microduplications at Xp21.2 and Xq13.1 in neurodevelopmental disorders.
Intellectual Disability
Identification of novel KIF11 mutations in patients with familial exudative vitreoretinopathy and a phenotypic analysis.
Intellectual Disability
Investigation on the isoform selectivity of novel kinesin-like protein 1 (KIF11) inhibitor using chemical feature based pharmacophore, molecular docking, and quantum mechanical studies.
Intellectual Disability
Involvement of the kinesin family members KIF4A and KIF5C in intellectual disability and synaptic function.
Intellectual Disability
KIF11 microdeletion is associated with microcephaly, chorioretinopathy and intellectual disability.
Intellectual Disability
KIF11 mutations are a common cause of autosomal dominant familial exudative vitreoretinopathy.
Intellectual Disability
KIF16B is a candidate gene for a novel autosomal-recessive intellectual disability syndrome.
Intellectual Disability
KIF1A variants are a frequent cause of autosomal dominant hereditary spastic paraplegia.
Intellectual Disability
Microcephaly with or without chorioretinopathy, lymphoedema, or mental retardation (MCLMR): review of phenotype associated with KIF11 mutations.
Intellectual Disability
Mutations in Kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development.
Intellectual Disability
Ocular manifestations of microcephaly with or without chorioretinopathy, lymphedema or intellectual disability (MCLID) syndrome associated with mutations in KIF11.
Intellectual Disability
Phenotypic Expansion in KIF1A-related Dominant Disorders: A Description of Novel Variants and Review of Published Cases.
Intellectual Disability
Phenotypic overlap between familial exudative vitreoretinopathy and microcephaly, lymphedema, and chorioretinal dysplasia caused by KIF11 mutations.
Intellectual Disability
PX Domain-Containing Kinesin KIF16B and Microtubule-Dependent Intracellular Movements.
Intellectual Disability
The Drosophila KIF1A Homolog unc-104 Is Important for Site-Specific Synapse Maturation.
Intellectual Disability
The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules.
Intellectual Disability
The KIF1A homolog Unc-104 is important for spontaneous release, postsynaptic density maturation and perisynaptic scaffold organization.
Intellectual Disability
The novel de novo mutation of KIF1A gene as the cause for Spastic paraplegia 30 in a Japanese case.
Intellectual Disability
Transport of Drosophila fragile X mental retardation protein-containing ribonucleoprotein granules by kinesin-1 and cytoplasmic dynein.
Ischemic Stroke
Evaluation of the genetic variants of kinesin motor protein in ischemic stroke.
Joint Instability
A novel multiple joint dislocation syndrome associated with a homozygous nonsense variant in the EXOC6B gene.
Joint Instability
Recurrent dominant mutations affecting two adjacent residues in the motor domain of the monomeric kinesin KIF22 result in skeletal dysplasia and joint laxity.
Kidney Diseases
Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1.
Kidney Diseases, Cystic
Loss of Glis2/NPHP7 causes kidney epithelial cell senescence and suppresses cyst growth in the Kif3a mouse model of cystic kidney disease.
Kidney Neoplasms
High kinesin family member 11 expression predicts poor prognosis in patients with clear cell renal cell carcinoma.
Leiomyosarcoma
Expression Profiling of the Cellular Processes in Uterine Leiomyomas: Omic Approaches and IGF-2 Association with Leiomyosarcomas.
Leiomyosarcoma
KIF15 upregulation promotes leiomyosarcoma cell growth via promoting USP15-mediated DEK deubiquitylation.
Leishmaniasis
Serodiagnosis of Asian leishmaniasis with a recombinant antigen from the repetitive domain of a Leishmania kinesin.
Leishmaniasis, Visceral
Kinesin motor domain of Leishmania donovani as a future vaccine candidate.
Leishmaniasis, Visceral
Leishmania infantum recombinant kinesin degenerated derived repeat (rKDDR): A novel potential antigen for serodiagnosis of visceral leishmaniasis.
Leukemia
Differential functional interplay of TOGp/XMAP215 and the KinI kinesin MCAK during interphase and mitosis.
Leukemia, Myeloid
Identification of a high-affinity network of secretagogin-binding proteins involved in vesicle secretion.
Leukemia, Myeloid, Acute
Association of kinesin family member 2A with increased disease risk, deteriorative clinical characteristics, and shorter survival profiles in acute myeloid leukemia.
Leukemia, T-Cell
A nuclear kinesin-like protein interacts with and stimulates the activity of the leucine-rich nuclear export signal of the human immunodeficiency virus type 1 rev protein.
Leukodystrophy, Globoid Cell
The sphingolipid psychosine inhibits fast axonal transport in Krabbe disease by activation of GSK3? and deregulation of molecular motors.
Leukoencephalopathies
KIF5A de novo mutation associated with myoclonic seizures and neonatal onset progressive leukoencephalopathy.
Lipomatosis
A Novel Synergistic Association of Variants in PTRH2 and KIF1A Relates to a Syndrome of Hereditary Axonopathy, Outer Hair Cell Dysfunction, Intellectual Disability, Pancreatic Lipomatosis, Diabetes, Cerebellar Atrophy, and Vertebral Artery Hypoplasia.
Lipomatosis
Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis.
Lissencephaly
Phenotype description in KIF5C gene hot-spot mutations responsible for malformations of cortical development (MCD).
Liver Diseases
PNPLA3 and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies and severity of underlying liver diseases.
Liver Diseases, Alcoholic
PNPLA3 and TM6SF2 variants as risk factors of hepatocellular carcinoma across various etiologies and severity of underlying liver diseases.
Liver Neoplasms
A survey of methylated candidate tumor suppressor genes in nasopharyngeal carcinoma.
Liver Neoplasms
High KIF18A expression correlates with unfavorable prognosis in primary hepatocellular carcinoma.
Liver Neoplasms
KIF11 Promotes Proliferation of Hepatocellular Carcinoma among Patients with Liver Cancers.
Liver Neoplasms
Pseudopod-associated protein KIF20B promotes Gli1-induced epithelial-mesenchymal transition modulated by pseudopodial actin dynamic in human colorectal cancer.
Liver Neoplasms
The role of kinesin KIF18A in the invasion and metastasis of hepatocellular carcinoma.
Lung Neoplasms
A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing.
Lung Neoplasms
Activation of KIF4A as a prognostic biomarker and therapeutic target for lung cancer.
Lung Neoplasms
Anaplastic lymphoma kinase as a new target for the treatment of non-small-cell lung cancer.
Lung Neoplasms
AURKA, DLGAP5, TPX2, KIF11 and CKAP5: Five specific mitosis-associated genes correlate with poor prognosis for non-small cell lung cancer patients.
Lung Neoplasms
Corrigendum: KIF3A binds to ?-arrestin for suppressing Wnt/?-catenin signalling independently of primary cilia in lung cancer.
Lung Neoplasms
Detection of RET (rearranged during transfection) variants and their downstream signal molecules in RET rearranged lung adenocarcinoma patients.
Lung Neoplasms
Downregulation of lumican enhanced mitotic defects and aneuploidy in lung cancer cells.
Lung Neoplasms
Expressions of Kif2c and Ki-67 in non-small cell lung cancer and their relationship with invasion and metastasis.
Lung Neoplasms
High expression of kinesin light chain-2, a novel target of miR-125b, is associated with poor clinical outcome of elderly non-small-cell lung cancer patients.
Lung Neoplasms
Identification of a novel KIF13A-RET fusion in lung adenocarcinoma by next-generation sequencing.
Lung Neoplasms
Identification of prognostic markers of lung cancer through bioinformatics analysis and in vitro experiments.
Lung Neoplasms
Impaired DNA double-strand breaks repair by kinesin family member 4A inhibition renders human H1299 non-small-cell lung cancer cells sensitive to cisplatin.
Lung Neoplasms
Increased KIF15 Expression Predicts a Poor Prognosis in Patients with Lung Adenocarcinoma.
Lung Neoplasms
Integrated analysis reveals key genes with prognostic value in lung adenocarcinoma.
Lung Neoplasms
KIF13A-regulated RhoB plasma membrane localization governs membrane blebbing and blebby amoeboid cell migration.
Lung Neoplasms
KIF14 messenger RNA expression is independently prognostic for outcome in lung cancer.
Lung Neoplasms
KIF2C exerts an oncogenic role in nonsmall cell lung cancer and is negatively regulated by miR-325-3p.
Lung Neoplasms
KIF3A binds to ?-arrestin for suppressing Wnt/?-catenin signalling independently of primary cilia in lung cancer.
Lung Neoplasms
KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling.
Lung Neoplasms
Kinesin family member 14: An independent prognostic marker and potential therapeutic target for ovarian cancer.
Lung Neoplasms
Kinesin family member 2A high expression correlates with advanced tumor stages and worse prognosis in non-small cell lung cancer patients.
Lung Neoplasms
Kinesin family member 2A promotes cancer cell viability, mobility, stemness, and chemoresistance to cisplatin by activating the PI3K/AKT/VEGF signaling pathway in non-small cell lung cancer.
Lung Neoplasms
Kinesin family member 3A inhibits the carcinogenesis of non-small cell lung cancer and prolongs survival.
Lung Neoplasms
Kinesin family member 3C (KIF3C) is a novel non-small cell lung cancer (NSCLC) oncogene whose expression is modulated by microRNA-150-5p (miR-150-5p) and microRNA-186-3p (miR-186-3p).
Lung Neoplasms
Kinesin KIF4A is associated with chemotherapeutic drug resistance by regulating intracellular trafficking of lung resistance-related protein.
Lung Neoplasms
Kinesin light chain 4 as a new target for lung cancer chemoresistance via targeted inhibition of checkpoint kinases in the DNA repair network.
Lung Neoplasms
Kinesin superfamily protein 21B acts as an oncogene in non-small cell lung cancer.
Lung Neoplasms
Novel genetic variants in KIF16B and NEDD4L in the endosome-related genes are associated with nonsmall cell lung cancer survival.
Lung Neoplasms
Preliminary study on the clinical significance of kinesin Kif18a in nonsmall cell lung cancer: An analysis of 100 cases.
Lung Neoplasms
Prognostic and clinicopathological significance of kinesin family member C1 in various cancers: A meta-analysis.
Lung Neoplasms
Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells.
Lung Neoplasms
Similarity and difference of pathogenesis among lung cancer subtypes suggested by expression profile data.
Lung Neoplasms
Small non-mucinous bronchioloalveolar carcinoma with anaplastic lymphoma kinase immunoreactivity: a novel ALK fusion gene?
Lung Neoplasms
Systemic and CNS activity of the RET inhibitor vandetanib combined with the mTOR inhibitor everolimus in KIF5B-RET re-arranged non-small cell lung cancer with brain metastases.
Lung Neoplasms
The expression of three genes in primary non-small cell lung cancer is associated with metastatic spread to the brain.
Lung Neoplasms
The overexpression of KIFC1 was associated with the proliferation and prognosis of non-small cell lung cancer.
Lung Neoplasms
Verification of expression of LINC00648 in the serum of lung cancer patients by TCGA database.
Lupus Erythematosus, Systemic
The spindle kinesin-like protein HsEg5 is an autoantigen in systemic lupus erythematosus.
Lymphatic Metastasis
Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer.
Lymphatic Metastasis
Enhanced expression of KIF4A in colorectal cancer is associated with lymph node metastasis.
Lymphatic Metastasis
High expression of KIF3A is a potential new parameter for the diagnosis and prognosis of breast cancer.
Lymphatic Metastasis
High kinesin family member 18A expression correlates with poor prognosis in primary lung adenocarcinoma.
Lymphatic Metastasis
Increased expression levels of AURKA and KIFC1 are promising predictors of progression and poor survival associated with gastric cancer.
Lymphatic Metastasis
KIF15 contributes to cell proliferation and migration in breast cancer.
Lymphatic Metastasis
KIF2C exerts an oncogenic role in nonsmall cell lung cancer and is negatively regulated by miR-325-3p.
Lymphatic Metastasis
Kinesin 18A expression clinical relevance to colorectal cancer progression.
Lymphatic Metastasis
Kinesin family member 2A high expression correlates with advanced tumor stages and worse prognosis in non-small cell lung cancer patients.
Lymphatic Metastasis
Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion.
Lymphatic Metastasis
Mitotic centromere-associated kinesin is a novel marker for prognosis and lymph node metastasis in colorectal cancer.
Lymphatic Metastasis
Preliminary study on the clinical significance of kinesin Kif18a in nonsmall cell lung cancer: An analysis of 100 cases.
Lymphatic Metastasis
Prognostic and clinicopathological significance of kinesin family member C1 in various cancers: A meta-analysis.
Lymphatic Metastasis
Silencing of KIF3B Suppresses Breast Cancer Progression by Regulating EMT and Wnt/?-Catenin Signaling.
Lymphatic Metastasis
Suppression of KIF3A inhibits triple negative breast cancer growth and metastasis by repressing Rb-E2F signaling and epithelial-mesenchymal transition.
Lymphatic Metastasis
Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF-? signaling.
Lymphedema
A mouse model for Kinesin Family Member 11 (Kif11)-associated familial exudative vitreoretinopathy.
Lymphedema
A novel KIF11 mutation in a Turkish patient with microcephaly, lymphedema, and chorioretinal dysplasia from a consanguineous family.
Lymphedema
Autosomal Dominant Microcephaly Associated With Congenital Lymphedema and Chorioretinopathy Due to a Novel Mutation in KIF11.
Lymphedema
Identification of novel KIF11 mutations in patients with familial exudative vitreoretinopathy and a phenotypic analysis.
Lymphedema
Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy.
Lymphedema
Ocular manifestations of microcephaly with or without chorioretinopathy, lymphedema or intellectual disability (MCLID) syndrome associated with mutations in KIF11.
Lymphedema
Phenotypic overlap between familial exudative vitreoretinopathy and microcephaly, lymphedema, and chorioretinal dysplasia caused by KIF11 mutations.
Lymphoma
Micronuclei in Kif18a mutant mice form stable micronuclear envelopes and do not promote tumorigenesis.
Lymphoma
Rapid response of brain metastasis to crizotinib in a patient with KLC1-ALK fusion and MET gene amplification positive non-small cell lung cancer: a case report.
Lymphoma
Small non-mucinous bronchioloalveolar carcinoma with anaplastic lymphoma kinase immunoreactivity: a novel ALK fusion gene?
Lymphoma, B-Cell
Long Non-Coding RNA Paternally Expressed Imprinted Gene 10 (PEG10) Elevates Diffuse Large B-Cell Lymphoma Progression by Regulating Kinesin Family Member 2A (KIF2A) via Targeting MiR-101-3p.
Lymphoma, Large B-Cell, Diffuse
Long Non-Coding RNA Paternally Expressed Imprinted Gene 10 (PEG10) Elevates Diffuse Large B-Cell Lymphoma Progression by Regulating Kinesin Family Member 2A (KIF2A) via Targeting MiR-101-3p.
Lymphoma, T-Cell
Comparative two-dimensional polyacrylamide gel electrophoresis of the salivary proteome of children with autism spectrum disorder.
Macular Degeneration
VEGFR2 Trafficking by KIF13B Is a Novel Therapeutic Target for Wet Age-Related Macular Degeneration.
Malformations of Cortical Development
Beta tubulin isoforms are not interchangeable for rescuing impaired radial migration due to Tubb3 knockdown.
Malformations of Cortical Development
Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly.
Malformations of Cortical Development
Mutations of KIF5C cause a neurodevelopmental disorder of infantile-onset epilepsy, absent language, and distinctive malformations of cortical development.
Malformations of Cortical Development
Phenotype description in KIF5C gene hot-spot mutations responsible for malformations of cortical development (MCD).
Malformations of Cortical Development
Variants in KIF2A cause broad clinical presentation; the computational structural analysis of a novel variant in a patient with a cortical dysplasia, complex, with other brain malformations 3.
Medulloblastoma
Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth.
Medulloblastoma
The kinesin KIF14 is overexpressed in medulloblastoma and downregulation of KIF14 suppressed tumor proliferation and induced apoptosis.
Melanoma
Growth arrest and apoptosis induced by kinesin Eg5 inhibitor K858 and by its 1,3,4-thiadiazoline analogue in tumor cells.
Melanoma
Intravital imaging of SRF and Notch signalling identifies a key role for EZH2 in invasive melanoma cells.
Melanoma
KIF13A-regulated RhoB plasma membrane localization governs membrane blebbing and blebby amoeboid cell migration.
Melanoma
Kinesin family member 18B: A contributor and facilitator in the proliferation and metastasis of cutaneous melanoma.
Melanoma
MicroRNA-203 Regulates Melanosome Transport and Tyrosinase Expression in Melanoma Cells by Targeting Kinesin Superfamily Protein 5b.
Meningioma
KIF11 inhibitors filanesib and ispinesib inhibit meningioma growth in vitro and in vivo.
Mesothelioma
Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma.
Mesothelioma, Malignant
Kinesin family members KIF11 and KIF23 as potential therapeutic targets in malignant pleural mesothelioma.
Microcephaly
A mouse model for Kinesin Family Member 11 (Kif11)-associated familial exudative vitreoretinopathy.
Microcephaly
A novel KIF11 mutation in a Turkish patient with microcephaly, lymphedema, and chorioretinal dysplasia from a consanguineous family.
Microcephaly
Autosomal Dominant Microcephaly Associated With Congenital Lymphedema and Chorioretinopathy Due to a Novel Mutation in KIF11.
Microcephaly
Congenital microcephaly and chorioretinopathy due to de novo heterozygous KIF11 mutations: five novel mutations and review of the literature.
Microcephaly
Cooperation Between Kinesin Motors Promotes Spindle Symmetry and Chromosome Organization in Oocytes.
Microcephaly
Corrigendum to "Congenital microcephaly and chorioretinopathy due to de novo heterozygous KIF11 mutations: Five novel mutations and review of the literature. Am J Med Genet Part A 2014 164A:2879-86".
Microcephaly
Detection and quantification of a KIF11 mosaicism in a subject presenting familial exudative vitreoretinopathy with microcephaly.
Microcephaly
First Report of a de novo 10q23.31q23.33 Microdeletion: Obesity, Intellectual Disability and Microcephaly.
Microcephaly
Genotype Phenotype Correlation and Variability in Microcephaly Associated With Chorioretinopathy or Familial Exudative Vitreoretinopathy.
Microcephaly
Goldberg-Shprintzen syndrome protein KIF1BP is a CITK interactor implicated in cytokinesis.
Microcephaly
Identification of novel KIF11 mutations in patients with familial exudative vitreoretinopathy and a phenotypic analysis.
Microcephaly
Inter-organelle interactions between the ER and mitotic spindle facilitates Zika protease cleavage of human Kinesin-5 and results in mitotic defects.
Microcephaly
Investigation on the isoform selectivity of novel kinesin-like protein 1 (KIF11) inhibitor using chemical feature based pharmacophore, molecular docking, and quantum mechanical studies.
Microcephaly
KIF11 microdeletion is associated with microcephaly, chorioretinopathy and intellectual disability.
Microcephaly
KIF11 mutations are a common cause of autosomal dominant familial exudative vitreoretinopathy.
Microcephaly
Microcephaly with or without chorioretinopathy, lymphoedema, or mental retardation (MCLMR): review of phenotype associated with KIF11 mutations.
Microcephaly
Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy.
Microcephaly
Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly.
Microcephaly
NEW FINDINGS FROM MULTIMODAL FUNDUS IMAGING OVER 3 YEARS OF A PATIENT WITH MICROCEPHALY, CHORIORETINOPATHY, AND KIF11 MUTATION.
Microcephaly
Novel variants in familial exudative vitreoretinopathy patients with KIF11 mutations and the Genotype-Phenotype correlation.
Microcephaly
Ocular manifestations of microcephaly with or without chorioretinopathy, lymphedema or intellectual disability (MCLID) syndrome associated with mutations in KIF11.
Microcephaly
Phenotypic overlap between familial exudative vitreoretinopathy and microcephaly, lymphedema, and chorioretinal dysplasia caused by KIF11 mutations.
Motor Neuron Disease
Disease-associated mutations hyperactivate KIF1A motility and anterograde axonal transport of synaptic vesicle precursors.
Motor Neuron Disease
Kinesin and cytoplasmic dynein in spinal spheroids with motor neuron disease.
Motor Neuron Disease
Kinesin mutations cause motor neuron disease phenotypes by disrupting fast axonal transport in Drosophila.
Mouth Neoplasms
Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer.
Mouth Neoplasms
Kinesin family member 14 in human oral cancer: A potential biomarker for tumoral growth.
Mouth Neoplasms
Kinesin family member 4A: a potential predictor for progression of human oral cancer.
Mouth Neoplasms
Screening for oral premalignancy and cancer: what platform and which biomarkers?
Multiple Myeloma
Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells.
Multiple Myeloma
Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.
Multiple Sclerosis
A cytoskeleton motor protein genetic variant may exert a protective effect on the occurrence of multiple sclerosis: the janus face of the kinesin light-chain 1 56836CC genetic variant.
Multiple Sclerosis
Abundant kif21b is associated with accelerated progression in neurodegenerative diseases.
Multiple Sclerosis
Axonal motor protein KIF5A and associated cargo deficits in multiple sclerosis lesional and normal-appearing white matter.
Multiple Sclerosis
Common genetic variants of the mitochondrial trafficking system and mitochondrial uncoupling proteins affect the development of two slowly developing demyelinating disorders, leukoaraiosis and multiple sclerosis.
Multiple Sclerosis
Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis.
Multiple Sclerosis
Kif1b is essential for mRNA localization in oligodendrocytes and development of myelinated axons.
Multiple Sclerosis
KIF5A and the contribution of susceptibility genotypes as a predictive biomarker for multiple sclerosis.
Multiple Sclerosis
Lack of replication of KIF1B gene in an Italian primary progressive multiple sclerosis cohort.
Multiple Sclerosis
Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis.
Multiple Sclerosis
No influence of KIF1B on neurodegenerative markers in multiple sclerosis.
Multiple Sclerosis
Polymorphic locus rs10492972 of the KIF1B gene association with multiple sclerosis in Russia: Case control study.
Multiple Sclerosis
The autoimmune disease-associated KIF5A, CD226 and SH2B3 gene variants confer susceptibility for multiple sclerosis.
Multiple Sclerosis
The rs10492972 KIF1B polymorphism and disease progression in Greek patients with multiple sclerosis.
Multiple Sclerosis
When is the absence of evidence, evidence of absence? Use of equivalence-based analyses in genetic epidemiology and a conclusion for the KIF1B rs10492972*C allelic association in multiple sclerosis.
Multiple Sclerosis
[Clinical and electrophysiological and molecular genetic characteristics of the course of relapsing-remitting multiple sclerosis].
Multiple Sclerosis, Chronic Progressive
Lack of replication of KIF1B gene in an Italian primary progressive multiple sclerosis cohort.
Multiple Sclerosis, Relapsing-Remitting
[Clinical and electrophysiological and molecular genetic characteristics of the course of relapsing-remitting multiple sclerosis].
Muscle Hypotonia
KIF5A mutations cause an infantile onset phenotype including severe myoclonus with evidence of mitochondrial dysfunction.
Muscle Spasticity
Co-existence of spastic paraplegia-30 with novel KIF1A mutation and spinocerebellar ataxia 31 with intronic expansion of BEAN and TK2 in a family.
Muscle Spasticity
Defective kinesin binding of TUBB2A causes progressive spastic ataxia syndrome resembling sacsinopathy.
Muscle Spasticity
Heterozygous KIF1A variants underlie a wide spectrum of neurodevelopmental and neurodegenerative disorders.
Muscle Spasticity
Intrafamilial variable spastic paraplegia/ataxia/ALS phenotype linked to a novel KIF5A mutation.
Muscle Weakness
Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta.
Muscular Atrophy, Spinal
Adult-onset distal spinal muscular atrophy: a new phenotype associated with KIF5A mutations.
Muscular Atrophy, Spinal
Molecular analysis and clinical diversity of distal hereditary motor neuropathy.
Muscular Atrophy, Spinal
Reply: Adult-onset distal spinal muscular atrophy: a new phenotype associated with KIF5A mutations.
Muscular Atrophy, Spinal
Small molecule suppressors of Drosophila Kinesin deficiency rescue motor axon development in a zebrafish model of spinal muscular atrophy.
Muscular Diseases
Sarcotubular Myopathy Due to Novel TRIM32 Mutation in Association with Multiple Sclerosis.
Myocardial Infarction
Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials.
Myocardial Infarction
Impact of KIF6 Polymorphism rs20455 on Coronary Heart Disease Risk and Effectiveness of Statin Therapy in 100 Patients from Southern Iran.
Myocardial Infarction
The polymorphism Trp719Arg in the kinesin-like protein 6 is associated with the presence of late outgrowth endothelial progenitor cells in acute myocardial infarction.
Myoclonus
KIF5A mutations cause an infantile onset phenotype including severe myoclonus with evidence of mitochondrial dysfunction.
Myositis
The kinesin superfamily motor protein KIF4 is associated with immune cell activation in idiopathic inflammatory myopathies.
Nasal Polyps
KIF3A, a Cilia Structural Gene on Chromosome 5q31, and Its Polymorphisms Show an Association with Aspirin Hypersensitivity in Asthma.
Nasopharyngeal Neoplasms
Overexpression of Kinesin Family Member 20A Correlates with Disease Progression and Poor Prognosis in Human Nasopharyngeal Cancer: A Retrospective Analysis of 105 Patients.
Neoplasm Metastasis
Binding of PLD2-Generated Phosphatidic Acid to KIF5B Promotes MT1-MMP Surface Trafficking and Lung Metastasis of Mouse Breast Cancer Cells.
Neoplasm Metastasis
C-terminal kinesin motor KIFC1 participates in facilitating proper cell division of human seminoma.
Neoplasm Metastasis
Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer.
Neoplasm Metastasis
Elevated expression of KIF18A enhances cell proliferation and predicts poor survival in human clear cell renal carcinoma.
Neoplasm Metastasis
Enhanced expression of KIF4A in colorectal cancer is associated with lymph node metastasis.
Neoplasm Metastasis
Expression of KIF18A Is Associated with Increased Tumor Stage and Cell Proliferation in Prostate Cancer.
Neoplasm Metastasis
Expressions of Kif2c and Ki-67 in non-small cell lung cancer and their relationship with invasion and metastasis.
Neoplasm Metastasis
Gene signatures and prognostic analyses of the Tob/BTG pituitary tumor-transforming gene (PTTG) family in clinical breast cancer patients.
Neoplasm Metastasis
High expression of KIF3A is a potential new parameter for the diagnosis and prognosis of breast cancer.
Neoplasm Metastasis
High kinesin family member 18A expression correlates with poor prognosis in primary lung adenocarcinoma.
Neoplasm Metastasis
Identification by Comprehensive Bioinformatics Analysis of KIF15 as a Candidate Risk Gene for Triple-Negative Breast Cancer.
Neoplasm Metastasis
Identification of five hub genes as monitoring biomarkers for breast cancer metastasis in silico.
Neoplasm Metastasis
Identification of hub genes associated with esophageal cancer progression using bioinformatics analysis.
Neoplasm Metastasis
Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer.
Neoplasm Metastasis
Increased expression levels of AURKA and KIFC1 are promising predictors of progression and poor survival associated with gastric cancer.
Neoplasm Metastasis
KIF11 is upregulated in colorectal cancer and silencing of it impairs tumor growth and sensitizes colorectal cancer cells to oxaliplatin via p53/GSK3? signaling.
Neoplasm Metastasis
KIF11 Serves as an Independent Prognostic Factor and Therapeutic Target for Patients With Lung Adenocarcinoma.
Neoplasm Metastasis
KIF14 promotes tumor progression and metastasis and is an independent predictor of poor prognosis in human gastric cancer.
Neoplasm Metastasis
KIF15 contributes to cell proliferation and migration in breast cancer.
Neoplasm Metastasis
KIF18B promotes tumor progression in osteosarcoma by activating ?-catenin.
Neoplasm Metastasis
KIF20A Affects the Prognosis of Bladder Cancer by Promoting the Proliferation and Metastasis of Bladder Cancer Cells.
Neoplasm Metastasis
KIF20A Predicts Poor Survival of Patients and Promotes Colorectal Cancer Tumor Progression through the JAK/STAT3 Signaling Pathway.
Neoplasm Metastasis
KIF26B, a novel oncogene, promotes proliferation and metastasis by activating the VEGF pathway in gastric cancer.
Neoplasm Metastasis
KIF2C exerts an oncogenic role in nonsmall cell lung cancer and is negatively regulated by miR-325-3p.
Neoplasm Metastasis
KIF2C: a novel link between Wnt/?-catenin and mTORC1 signaling in the pathogenesis of hepatocellular carcinoma.
Neoplasm Metastasis
KIF3B protein expression loss correlates with metastatic ability of prostate cancer.
Neoplasm Metastasis
KIF4A facilitates cell proliferation via induction of p21-mediated cell cycle progression and promotes metastasis in colorectal cancer.
Neoplasm Metastasis
KIFC1 is activated by TCF-4 and promotes hepatocellular carcinoma pathogenesis by regulating HMGA1 transcriptional activity.
Neoplasm Metastasis
KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling.
Neoplasm Metastasis
KIFC1, a novel potential prognostic factor and therapeutic target in hepatocellular carcinoma.
Neoplasm Metastasis
Kinesin 18A expression clinical relevance to colorectal cancer progression.
Neoplasm Metastasis
Kinesin Family Member 11 Enhances the Self-Renewal Ability of Breast Cancer Cells by Participating in the Wnt/?-Catenin Pathway.
Neoplasm Metastasis
Kinesin family member 15 promotes cancer stem cell phenotype and malignancy via reactive oxygen species imbalance in hepatocellular carcinoma.
Neoplasm Metastasis
Kinesin Family Member 18A (KIF18A) Contributes to the Proliferation, Migration, and Invasion of Lung Adenocarcinoma Cells In Vitro and In Vivo.
Neoplasm Metastasis
Kinesin family member 18B: A contributor and facilitator in the proliferation and metastasis of cutaneous melanoma.
Neoplasm Metastasis
Kinesin family member 2A high expression correlates with advanced tumor stages and worse prognosis in non-small cell lung cancer patients.
Neoplasm Metastasis
Kinesin family member 2C promotes hepatocellular carcinoma growth and metastasis via activating MEK/ERK pathway.
Neoplasm Metastasis
Kinesin family member 3A inhibits the carcinogenesis of non-small cell lung cancer and prolongs survival.
Neoplasm Metastasis
Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo.
Neoplasm Metastasis
Kinesin family member 3C (KIF3C) is a novel non-small cell lung cancer (NSCLC) oncogene whose expression is modulated by microRNA-150-5p (miR-150-5p) and microRNA-186-3p (miR-186-3p).
Neoplasm Metastasis
Kinesin family member C1 accelerates bladder cancer cell proliferation and induces epithelial-mesenchymal transition via Akt/GSK3? signaling.
Neoplasm Metastasis
Kinesin-5 Contributes to Spindle-length Scaling in the Evolution of Cancer toward Metastasis.
Neoplasm Metastasis
Knockdown of circHIPK3 Facilitates Temozolomide Sensitivity in Glioma by Regulating Cellular Behaviors Through miR-524-5p/KIF2A-Mediated PI3K/AKT Pathway.
Neoplasm Metastasis
Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion.
Neoplasm Metastasis
Micro1278 Leads to Tumor Growth Arrest, Enhanced Sensitivity to Oxaliplatin and Vitamin D and Inhibits Metastasis via KIF5B, CYP24A1, and BTG2, Respectively.
Neoplasm Metastasis
MiR-19a/miR-96-mediated low expression of KIF26A suppresses metastasis by regulating FAK pathway in gastric cancer.
Neoplasm Metastasis
Mitotic centromere-associated kinesin is a novel marker for prognosis and lymph node metastasis in colorectal cancer.
Neoplasm Metastasis
Preliminary study on the clinical significance of kinesin Kif18a in nonsmall cell lung cancer: An analysis of 100 cases.
Neoplasm Metastasis
Prognostic and clinicopathological significance of kinesin family member C1 in various cancers: A meta-analysis.
Neoplasm Metastasis
PX Domain-Containing Kinesin KIF16B and Microtubule-Dependent Intracellular Movements.
Neoplasm Metastasis
RNA Interference of IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Cell Proliferation and Invasion in Breast Carcinoma Cells.
Neoplasm Metastasis
Silencing of KIF3B Suppresses Breast Cancer Progression by Regulating EMT and Wnt/?-Catenin Signaling.
Neoplasm Metastasis
Suppression of KIF3A inhibits triple negative breast cancer growth and metastasis by repressing Rb-E2F signaling and epithelial-mesenchymal transition.
Neoplasm Metastasis
Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF-? signaling.
Neoplasm Metastasis
The expression of three genes in primary non-small cell lung cancer is associated with metastatic spread to the brain.
Neoplasm Metastasis
The kinesin motor protein KIF4A as a potential therapeutic target in renal cell carcinoma.
Neoplasm Metastasis
The role of kinesin KIF18A in the invasion and metastasis of hepatocellular carcinoma.
Neoplasm Metastasis
TPX2-p53-GLIPR1 regulatory circuitry in cell proliferation, invasion, and tumor growth of bladder cancer.
Neoplasm Metastasis
Upregulate KIF4A Enhances Proliferation, Invasion of Hepatocellular Carcinoma and Indicates poor prognosis Across Human Cancer Types.
Neoplasms
"Snapshots" of ispinesib-induced conformational changes in the mitotic kinesin Eg5.
Neoplasms
3D-QSAR Studies of Dihydropyrazole and Dihydropyrrole Derivatives as Inhibitors of Human Mitotic Kinesin Eg5 Based on Molecular Docking.
Neoplasms
A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian adenocarcinomas.
Neoplasms
A cluster of genes located in 1p36 are down-regulated in neuroblastomas with poor prognosis, but not due to CpG island methylation.
Neoplasms
A germline mutation of the KIF1B beta gene on 1p36 in a family with neural and nonneural tumors.
Neoplasms
A molecular portrait of gastrointestinal stromal tumors: an integrative analysis of gene expression profiling and high-resolution genomic copy number.
Neoplasms
A Monastrol-derived Compound, LaSOM 63, Inhibits Ecto-5'Nucleotidase/CD73 Activity and Induces Apoptotic Cell Death of Glioma Cell Lines.
Neoplasms
A reconstituted mammalian APC-kinesin complex selectively transports defined packages of axonal mRNAs.
Neoplasms
A role for kinesin-1 subunits KIF5B/KLC1 in regulating epithelial mesenchymal plasticity in breast tumorigenesis.
Neoplasms
A role for metaphase spindle elongation forces in correction of merotelic kinetochore attachments.
Neoplasms
A specific gene expression signature for visceral organ metastasis in breast cancer.
Neoplasms
Aberrantly activated Gli2-KIF20A axis is crucial for growth of hepatocellular carcinoma and predicts poor prognosis.
Neoplasms
Acentrosomal spindle organization renders cancer cells dependent on the kinesin HSET.
Neoplasms
Activation of KIF4A as a prognostic biomarker and therapeutic target for lung cancer.
Neoplasms
Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells.
Neoplasms
An integrated bioinformatical analysis to evaluate the role of KIF4A as a prognostic biomarker for breast cancer.
Neoplasms
An intermittent live cell imaging screen for siRNA enhancers and suppressors of a kinesin-5 inhibitor.
Neoplasms
An interphase pool of KIF11 localizes at the basal bodies of primary cilia and a reduction in KIF11 expression alters cilia dynamics.
Neoplasms
Analysis of Cell-Free DNA from 32,989 Advanced Cancers Reveals Novel Co-occurring Activating RET Alterations and Oncogenic Signaling Pathway Aberrations.
Neoplasms
Antiangiogenic Therapeutic Potential of Peptides Derived from the Molecular Motor KIF13B that Transports VEGFR2 to Plasmalemma in Endothelial Cells.
Neoplasms
ARF6-JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion.
Neoplasms
B7-H3 regulates KIF15-activated ERK1/2 pathway and contributes to radioresistance in colorectal cancer.
Neoplasms
Bioinformatics Analysis of KIF1A Expression and Gene Regulation Network in Ovarian Carcinoma.
Neoplasms
C-terminal kinesin motor KIFC1 participates in facilitating proper cell division of human seminoma.
Neoplasms
Cell death response to anti-mitotic drug treatment in cell culture, mouse tumor model and the clinic.
Neoplasms
Centromere-associated protein E: a motor that puts the brakes on the mitotic checkpoint.
Neoplasms
Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
Neoplasms
Chemogenetic evaluation of the mitotic kinesin CENP-E reveals a critical role in triple-negative breast cancer.
Neoplasms
Chromosomally unstable tumor cells specifically require KIF18A for proliferation.
Neoplasms
Clinical Significance And Integrative Analysis Of Kinesin Family Member 18B In Lung Adenocarcinoma.
Neoplasms
Clinical significance of kinesin family member 2A as a facilitating biomarker of disease surveillance and prognostication in cervical cancer patients.
Neoplasms
Clinical value of Xenopus kinesin-like protein 2 as a prognostic marker in patients with digestive system cancers: a systematic review and meta-analysis.
Neoplasms
Clinicopathological relevance of kinesin family member 18A expression in invasive breast cancer.
Neoplasms
Clinicopathological Significance and Antitumor Effect of MPHOSPH1 in Testicular Germ Cell Tumor.
Neoplasms
Co-expression network analysis identified KIF2C in association with progression and prognosis in lung adenocarcinoma.
Neoplasms
Combination of active and inactive siRNA targeting the mitotic kinesin Eg5 impairs silencing efficiency in several cancer cell lines.
Neoplasms
Comparison of the Effects of Monastrol and Oxomonastrol on Human Hepatoma Cell Line HepG2/C3A.
Neoplasms
Comprehensive analysis of microRNA-messenger RNA regulatory network in gemcitabine-resistant bladder cancer cells.
Neoplasms
Concordance between Comprehensive Cancer Genome Profiling in Plasma and Tumor Specimens.
Neoplasms
Consensus transcriptome signature of perineural invasion in pancreatic carcinoma.
Neoplasms
Correlation between BRAF mutation and promoter methylation of TIMP3, RAR?2 and RASSF1A in thyroid cancer.
Neoplasms
Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells.
Neoplasms
Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth.
Neoplasms
Detection of RET (rearranged during transfection) variants and their downstream signal molecules in RET rearranged lung adenocarcinoma patients.
Neoplasms
Dihydropyrazole and dihydropyrrole structures based design of Kif15 inhibitors as novel therapeutic agents for cancer.
Neoplasms
Discovery and Mechanistic Study of a Small Molecule Inhibitor for Motor Protein KIFC1.
Neoplasms
Discovery and Validation of Methylation Biomarkers for Ulcerative Colitis Associated Neoplasia.
Neoplasms
Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening.
Neoplasms
Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.
Neoplasms
Distinct Diagnostic and Prognostic Values of Kinesin Family Member Genes Expression in Patients with Breast Cancer.
Neoplasms
Distinct Mechanisms of Resistance to a CENP-E Inhibitor Emerge in Near-Haploid and Diploid Cancer Cells.
Neoplasms
Distinct retrograde microtubule motor sets drive early and late endosome transport.
Neoplasms
Distinctions between dynamic characteristics of the single EG5 motor protein along neural vs. cancerous microtubules.
Neoplasms
DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables.
Neoplasms
Down-regulation of KIF2A inhibits gastric cancer cell invasion via suppressing MT1-MMP.
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Effects of Eg5 knockdown on human prostate cancer xenograft growth and chemosensitivity.
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Effects of KIF2A on the prognosis of nasopharyngeal carcinoma and nasopharyngeal carcinoma cells.
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Eg5 as a Prognostic Biomarker and Potential Therapeutic Target for Hepatocellular Carcinoma.
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Elevated expression of KIF18A enhances cell proliferation and predicts poor survival in human clear cell renal carcinoma.
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Elevated kinesin family member 26B is a prognostic biomarker and a potential therapeutic target for colorectal cancer.
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Endothelin receptor type B gene promoter hypermethylation in salivary rinses is independently associated with risk of oral cavity cancer and premalignancy.
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Enhanced expression of KIF4A in colorectal cancer is associated with lymph node metastasis.
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Exploring a potential allosteric inhibition mechanism in the motor domain of human Eg-5.
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Expressed sequence tag (EST) phenotyping of HT-29 cells: cloning of ser/thr protein kinase EMK1, kinesin KIF3B, and of transcripts that include Alu repeated elements.
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Expression of KIF18A Is Associated with Increased Tumor Stage and Cell Proliferation in Prostate Cancer.
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Expression of Kif5b protein is significantly associated with the progression, recurrence and prognosis of oral squamous cell carcinoma.
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Expression of targeting protein for Xenopus kinesin-like protein 2 is associated with progression of human malignant astrocytoma.
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Functional analysis of phosphorylation of the mitotic centromere-associated kinesin by Aurora B kinase in human tumor cells.
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GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes.
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Gene expression differences predict treatment outcome of merkel cell carcinoma patients.
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Gene expression of cytokinesis regulators PRC1, KIF14 and CIT has no prognostic role in colorectal and pancreatic cancer.
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Genetic polymorphism of the kinesin-like protein KIF1B gene and the risk of hepatocellular carcinoma.
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Genetic predisposition to neural crest-derived tumors: revisiting the role of KIF1B.
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Germline variant in REXO2 is a novel candidate gene in familial pheochromocytoma.
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Growth arrest and apoptosis induced by kinesin Eg5 inhibitor K858 and by its 1,3,4-thiadiazoline analogue in tumor cells.
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GSG2 (Haspin) promotes development and progression of bladder cancer through targeting KIF15 (Kinase-12).
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HDAC6 Signaling at Primary Cilia Promotes Proliferation and Restricts Differentiation of Glioma Cells.
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High expression of KIF14 is associated with poor prognosis in patients with epithelial ovarian cancer.
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High Expression of KIF20A Is Associated with Poor Overall Survival and Tumor Progression in Early-Stage Cervical Squamous Cell Carcinoma.
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High KIF18A expression correlates with unfavorable prognosis in primary hepatocellular carcinoma.
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High KIF2A expression predicts unfavorable prognosis in diffuse large B cell lymphoma.
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High KIF2A expression promotes proliferation, migration and predicts poor prognosis in lung adenocarcinoma.
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High kinesin family member 11 expression predicts poor prognosis in patients with clear cell renal cell carcinoma.
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High kinesin family member 18A expression correlates with poor prognosis in primary lung adenocarcinoma.
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How Essential Kinesin-5 Becomes Non-Essential in Fission Yeast: Force Balance and Microtubule Dynamics Matter.
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Human Mitotic Centromere-Associated Kinesin Is Targeted by MicroRNA 485-5p/181c and Prognosticates Poor Survivability of Breast Cancer.
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Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.
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Identification and validation of core genes for serous ovarian adenocarcinoma via bioinformatics analysis.
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Identification by Comprehensive Bioinformatics Analysis of KIF15 as a Candidate Risk Gene for Triple-Negative Breast Cancer.
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Identification of a link between the tumour suppressor APC and the kinesin superfamily.
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Identification of cytoskeleton-associated proteins essential for lysosomal stability and survival of human cancer cells.
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Identification of HLA-A24-restricted novel T Cell epitope peptides derived from P-cadherin and kinesin family member 20A.
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Identification of KIF15 as a potential therapeutic target and prognostic factor for glioma.
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Identification of KIF4A and its effect on the progression of lung adenocarcinoma based on the bioinformatics analysis.
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Identification of KIF4A as a pan-cancer diagnostic and prognostic biomarker via bioinformatics analysis and validation in osteosarcoma cell lines.
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Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer.
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Identification of molecular markers and signaling pathway in endometrial cancer in Hong Kong Chinese women by genome-wide gene expression profiling.
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Identification of potential prognostic biomarkers for breast cancer using WGCNA and PPI integrated techniques.
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Identification of prognostic markers by weighted gene co-expression network analysis in non-small cell lung cancer.
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Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen.
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Identifying common prognostic factors in genomic cancer studies: a novel index for censored outcomes.
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Impaired angiogenesis and tumor development by inhibition of the mitotic kinesin Eg5.
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Increased expression levels of AURKA and KIFC1 are promising predictors of progression and poor survival associated with gastric cancer.
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Increased expression of KPNA2 predicts unfavorable prognosis in ovarian cancer patients, possibly by targeting KIF4A signaling.
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Increased KIF15 Expression Predicts a Poor Prognosis in Patients with Lung Adenocarcinoma.
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Increased KIF21B expression is a potential prognostic biomarker in hepatocellular carcinoma.
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Induction of apoptosis by monastrol, an inhibitor of the mitotic kinesin Eg5, is independent of the spindle checkpoint.
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Inhibition of KIF14 Suppresses Tumor Cell Growth and Promotes Apoptosis in Human Glioblastoma.
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Inhibition of kinesin motor protein KIFC1 by AZ82 induces multipolar mitosis and apoptosis in prostate cancer cell.
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Inhibition of kinesin-5 improves regeneration of injured axons by a novel microtubule-based mechanism.
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Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells.
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Initial testing of the CENP-E inhibitor GSK923295A by the pediatric preclinical testing program.
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Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer.
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Investigation on the isoform selectivity of novel kinesin-like protein 1 (KIF11) inhibitor using chemical feature based pharmacophore, molecular docking, and quantum mechanical studies.
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K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells.
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KIF-2C expression is correlated with poor prognosis of operable esophageal squamous cell carcinoma male patients.
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KIF11 and KIF15 mitotic kinesins are potential therapeutic vulnerabilities for malignant peripheral nerve sheath tumors.
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KIF11 as a potential cancer prognostic marker promotes tumorigenesis in children with Wilms tumor.
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KIF11 Functions as an Oncogene and Is Associated with Poor Outcomes from Breast Cancer.
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KIF11 inhibition for glioblastoma treatment: reason to hope or a struggle with the brain?
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KIF11 inhibitors filanesib and ispinesib inhibit meningioma growth in vitro and in vivo.
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KIF11 is required for proliferation and self-renewal of docetaxel resistant triple negative breast cancer cells.
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KIF11 is upregulated in colorectal cancer and silencing of it impairs tumor growth and sensitizes colorectal cancer cells to oxaliplatin via p53/GSK3? signaling.
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KIF11 promotes cell proliferation via ERBB2/PI3K/AKT signaling pathway in gallbladder cancer.
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KIF11 Promotes Proliferation of Hepatocellular Carcinoma among Patients with Liver Cancers.
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KIF11 silencing and inhibition induces chromosome instability that may contribute to cancer.
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KIF14 messenger RNA expression is independently prognostic for outcome in lung cancer.
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KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer.
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KIF14 promotes cell proliferation via activation of Akt and is directly targeted by miR-200c in colorectal cancer.
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KIF14 promotes tumor progression and metastasis and is an independent predictor of poor prognosis in human gastric cancer.
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KIF15 Expression in Tumor-associated Monocytes Is a Prognostic Biomarker in Hepatocellular Carcinoma.
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KIF15 facilitates gastric cancer via enhancing proliferation, inhibiting apoptosis, and predict poor prognosis.
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KIF15 nanomechanics and kinesin inhibitors, with implications for cancer chemotherapeutics.
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KIF15 promotes the evolution of gastric cancer cells through inhibition of reactive oxygen species-mediated apoptosis.
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KIF15 upregulation promotes leiomyosarcoma cell growth via promoting USP15-mediated DEK deubiquitylation.
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KIF15-Mediated Stabilization of AR and AR-V7 Contributes to Enzalutamide Resistance in Prostate Cancer.
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KIF18A knockdown reduces proliferation, migration, invasion and enhances radiosensitivity of esophageal cancer.
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KIF1B and NF1 are the most frequently mutated genes in paraganglioma and pheochromocytoma tumors.
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KIF1B promotes glioma migration and invasion via cell surface localization of MT1-MMP.
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KIF20A expression as a prognostic indicator and its possible involvement in the proliferation of ovarian clear?cell carcinoma cells.
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KIF20A mRNA and its product MKlp2 are increased during hepatocyte proliferation and hepatocarcinogenesis.
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KIF20A Predicts Poor Survival of Patients and Promotes Colorectal Cancer Tumor Progression through the JAK/STAT3 Signaling Pathway.
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KIF20A promotes cellular malignant behavior and enhances resistance to chemotherapy in colorectal cancer through regulation of the JAK/STAT3 signaling pathway.
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KIF20A silence inhibits the migration, invasion and proliferation of non-small cell lung cancer and regulates the JNK pathway.
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KIF22 promotes progress of esophageal squamous cell carcinoma cells and is negatively regulated by miR-122.
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KIF23 promotes triple negative breast cancer through activating epithelial-mesenchymal transition.
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KIF26B, a novel oncogene, promotes proliferation and metastasis by activating the VEGF pathway in gastric cancer.
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KIF2A Overexpression and Its Association with Clinicopathologic Characteristics and Poor Prognoses in Patients with Gastric Cancer.
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KIF2A overexpression and its association with clinicopathologic characteristics and unfavorable prognosis in colorectal cancer.
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KIF2A promotes the progression via AKT signaling pathway and is upregulated by transcription factor ETV4 in human gastric cancer.
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KIF2A silencing inhibits the proliferation and migration of breast cancer cells and correlates with unfavorable prognosis in breast cancer.
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KIF2C exerts an oncogenic role in nonsmall cell lung cancer and is negatively regulated by miR-325-3p.
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KIF2C promotes the proliferation of hepatocellular carcinoma cells in vitro and in vivo.
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KIF2C: a novel link between Wnt/?-catenin and mTORC1 signaling in the pathogenesis of hepatocellular carcinoma.
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KIF3a Promotes Proliferation and Invasion via Wnt Signaling in Advanced Prostate Cancer.
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KIF3B protein expression loss correlates with metastatic ability of prostate cancer.
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KIF3C is associated with favorable prognosis in glioma patients and may be regulated by PI3K/AKT/mTOR pathway.
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KIF3C Promotes Proliferation, Migration, and Invasion of Glioma Cells by Activating the PI3K/AKT Pathway and Inducing EMT.
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KIF4A enhanced cell proliferation and migration via Hippo signaling and predicted a poor prognosis in esophageal squamous cell carcinoma.
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KIF4A facilitates cell proliferation via induction of p21-mediated cell cycle progression and promotes metastasis in colorectal cancer.
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KIF4A Promotes Clear Cell Renal Cell Carcinoma (ccRCC) Proliferation in vitro and in vivo.
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KIF4A promotes the development of bladder cancer by transcriptionally activating the expression of CDCA3.
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KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer.
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KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms.
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KIFC1 Inhibitor CW069 Induces Apoptosis and Reverses Resistance to Docetaxel in Prostate Cancer.
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KIFC1 Is Essential for Bipolar Spindle Formation and Genomic Stability in the Primary Human Fibroblast IMR-90 Cell.
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KIFC1 promotes the proliferation of hepatocellular carcinoma in vitro and in vivo.
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KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling.
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KIFC1 regulates ZWINT to promote tumor progression and spheroid formation in colorectal cancer.
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KIFC1, a novel potential prognostic factor and therapeutic target in hepatocellular carcinoma.
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KIFCI, a novel putative prognostic biomarker for ovarian adenocarcinomas: delineating protein interaction networks and signaling circuitries.
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Kinesin 12 (KIF15) contributes to the development and tumorigenicity of prostate cancer.
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Kinesin Family Deregulation Coordinated by Bromodomain Protein ANCCA and Histone Methyltransferase MLL for Breast Cancer Cell Growth, Survival, and Tamoxifen Resistance.
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Kinesin Family Member 11 Enhances the Self-Renewal Ability of Breast Cancer Cells by Participating in the Wnt/?-Catenin Pathway.
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Kinesin family member 11 is a potential therapeutic target and is suppressed by microRNA-30a in breast cancer.
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Kinesin Family Member 11 mRNA Expression Predicts Prostate Cancer Aggressiveness.
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Kinesin family member 15 promotes cancer stem cell phenotype and malignancy via reactive oxygen species imbalance in hepatocellular carcinoma.
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Kinesin Family Member 18A (KIF18A) Contributes to the Proliferation, Migration, and Invasion of Lung Adenocarcinoma Cells In Vitro and In Vivo.
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Kinesin family member 18B regulates the proliferation and invasion of human prostate cancer cells.
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Kinesin family member 20B regulates tongue cancer progression by promoting cell proliferation.
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Kinesin family member 2A high expression correlates with advanced tumor stages and worse prognosis in non-small cell lung cancer patients.
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Kinesin family member 2A promotes cancer cell viability, mobility, stemness, and chemoresistance to cisplatin by activating the PI3K/AKT/VEGF signaling pathway in non-small cell lung cancer.
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Kinesin family member 2C aggravates the progression of hepatocellular carcinoma and interacts with competing endogenous RNA.
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Kinesin family member 3A inhibits the carcinogenesis of non-small cell lung cancer and prolongs survival.
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Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo.
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Kinesin Family Member C1 (KIFC1) Accelerates Proliferation and Invasion of Endometrial Cancer Cells Through Modulating the PI3K/AKT Signaling Pathway.
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Kinesin Family Member C1 (KIFC1) Regulated by Centrosome Protein E (CENPE) Promotes Proliferation, Migration, and Epithelial-Mesenchymal Transition of Ovarian Cancer.
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Kinesin family member C1 accelerates bladder cancer cell proliferation and induces epithelial-mesenchymal transition via Akt/GSK3? signaling.
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Kinesin Family Member C1 Increases Temozolomide Resistance of Glioblastoma Through Promoting DNA Damage Repair.
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Kinesin family member-18A (KIF18A) is a predictive biomarker of poor benefit from endocrine therapy in early ER+?breast cancer.
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Kinesin family members KIF2C/4A/10/11/14/18B/20A/23 predict poor prognosis and promote cell proliferation in hepatocellular carcinoma.
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Kinesin light chain-4 depletion induces apoptosis of radioresistant cancer cells by mitochondrial dysfunction via calcium ion influx.
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Kinesin motor protein KIFC1 is a target protein of miR-338-3p and associated with poor prognosis and progression of renal cell carcinoma.
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Kinesin Superfamily Member 18B (KIF18B) Promotes Cell Proliferation in Colon Adenocarcinoma.
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Kinesin superfamily protein 21B acts as an oncogene in non-small cell lung cancer.
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Kinesin-5 Contributes to Spindle-length Scaling in the Evolution of Cancer toward Metastasis.
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Knockdown of KIF15 promotes cell apoptosis by activating crosstalk of multiple pathways in ovarian cancer: bioinformatic and experimental analysis.
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Knockdown of KIF26B inhibits breast cancer cell proliferation, migration, and invasion.
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Knockdown of Kinase Family 15 Inhibits Cancer Cell Proliferation In vitro and its Clinical Relevance in Triple-Negative Breast Cancer.
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Knockdown of Kinesin Family 15 Inhibits Osteosarcoma through Suppressing Cell Proliferation and Promoting Cell Apoptosis.
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LDL receptor related protein 1 requires the I3 domain of discs-large homolog 1/DLG1 for interaction with the kinesin motor protein KIF13B.
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Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.
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METTL3-mediated m6A modification of KIF3C-mRNA promotes prostate cancer progression and is negatively regulated by miR-320d.
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Micro1278 Leads to Tumor Growth Arrest, Enhanced Sensitivity to Oxaliplatin and Vitamin D and Inhibits Metastasis via KIF5B, CYP24A1, and BTG2, Respectively.
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Micronuclei in Kif18a mutant mice form stable micronuclear envelopes and do not promote tumorigenesis.
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miR-135a acts as a tumor suppressor in gastric cancer in part by targeting KIFC1.
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MiR-19a/miR-96-mediated low expression of KIF26A suppresses metastasis by regulating FAK pathway in gastric cancer.
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MiR-29a-5p inhibits proliferation and invasion and induces apoptosis in endometrial carcinoma via targeting TPX2.
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miR-450b-5p loss mediated KIF26B activation promoted hepatocellular carcinoma progression by activating PI3K/AKT pathway.
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Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive cancer cells.
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Mitotic slippage and expression of survivin are linked to differential sensitivity of human cancer cell-lines to the Kinesin-5 inhibitor monastrol.
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Mobility of the von Hippel-Lindau tumour suppressor protein is regulated by kinesin-2.
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Molecular analysis of plasma DNA for the early detection of lung cancer by quantitative methylation-specific PCR.
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Molecular characterization of tumors from a transgenic mouse adrenal tumor model: comparison with human pheochromocytoma.
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Mutational study of the 1p located genes p18ink4c, Patched-2, RIZ1 and KIF1B in oligodendrogliomas.
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Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl-L-cysteine in tumor derived cell lines.
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Navitoclax (ABT-263) accelerates apoptosis during drug-induced mitotic arrest by antagonizing Bcl-xL.
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New insights into the mechanism of force generation by kinesin-5 molecular motors.
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New MKLP-2 inhibitors in the paprotrain series: Design, synthesis and biological evaluations.
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Novel Allosteric Pathway of Eg5 Regulation Identified through Multivariate Statistical Analysis of Hydrogen-Exchange Mass Spectrometry (HX-MS) Ligand Screening Data.
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Novel photochromic inhibitor for mitotic kinesin Eg5 which forms multiple isomerization states.
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Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14.
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Overexpressed targeting protein for Xklp2 (TPX2) serves as a promising prognostic marker and therapeutic target for gastric cancer.
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Overexpression of autocrine motility factor in metastatic tumor cells: possible association with augmented expression of KIF3A and GDI-beta.
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Overexpression of KIF18A promotes cell proliferation, inhibits apoptosis, and independently predicts unfavorable prognosis in lung adenocarcinoma.
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Overexpression of KIF20A confers malignant phenotype of lung adenocarcinoma by promoting cell proliferation and inhibiting apoptosis.
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Overexpression of KIF23 predicts clinical outcome in primary lung cancer patients.
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Overexpression of Kinesin Family Member 20A Correlates with Disease Progression and Poor Prognosis in Human Nasopharyngeal Cancer: A Retrospective Analysis of 105 Patients.
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Overexpression of kinesin family member 20A is associated with unfavorable clinical outcome and tumor progression in epithelial ovarian cancer.
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Overexpression of TPX2 predicts poor clinical outcome and is associated with immune infiltration in hepatic cell cancer.
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Phase II study to assess the efficacy, safety and tolerability of the mitotic spindle kinesin inhibitor AZD4877 in patients with recurrent advanced urothelial cancer.
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Photocontrol of the mitotic kinesin Eg5 using a novel S-trityl-L-cysteine analogue as a photochromic inhibitor.
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Potentiation of kinesin spindle protein inhibitor-induced cell death by modulation of mitochondrial and death receptor apoptotic pathways.
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Preferential killing of tetraploid tumor cells by targeting the mitotic kinesin Eg5.
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Preliminary study on the clinical significance of kinesin Kif18a in nonsmall cell lung cancer: An analysis of 100 cases.
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Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis.
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Prognostic and clinical value of Targeting protein for Xenopus kinesin-like protein 2 in patients with gastrointestinal tract cancers: A meta-analysis.
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Prognostic and clinicopathological significance of kinesin family member C1 in various cancers: A meta-analysis.
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Prognostic Genes of Breast Cancer Identified by Gene Co-expression Network Analysis.
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Prognostic implications of immune-related eight-gene signature in pediatric brain tumors.
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Prognostic Significance of KIF11 and KIF14 Expression in Pancreatic Adenocarcinoma.
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Prognostic significance of KIF2A and KIF20A expression in human cancer: A systematic review and meta-analysis.
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Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction.
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Properties of kinesin isolated from human prostatic DU 145 tumor cells and bovine brain.
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Protrudin-mediated ER-endosome contact sites promote MT1-MMP exocytosis and cell invasion.
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PX Domain-Containing Kinesin KIF16B and Microtubule-Dependent Intracellular Movements.
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Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate.
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Recent findings and future directions for interpolar mitotic kinesin inhibitors in cancer therapy.
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Reduced expression of CENP-E contributes to the development of hepatocellular carcinoma and is associated with adverse clinical features.
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Regulation of kinesin expression and type IV collagenase secretion in invasive human prostate PC-3 tumor sublines.
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Relevance of aneuploidy for cancer therapies targeting the spindle assembly checkpoint and KIF18A.
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RNA Helicase A Is a Downstream Mediator of KIF1B? Tumor-Suppressor Function in Neuroblastoma.
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Role of single nucleotide polymorphisms of KIF1B gene in HBV-associated viral hepatitis.
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Screening for gene mutations in a 500 kb neuroblastoma tumor suppressor candidate region in chromosome 1p; mutation and stage-specific expression in UBE4B/UFD2.
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Significant decrease of ADP release rate underlies the potent activity of dimethylenastron to inhibit mitotic kinesin Eg5 and cancer cell proliferation.
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Silencing BMI1 eliminates tumor formation of pediatric glioma CD133+ cells not by affecting known targets but by down-regulating a novel set of core genes.
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Silencing KIF18B enhances radiosensitivity: identification of a promising therapeutic target in sarcoma.
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Silencing of KIF14 interferes with cell cycle progression and cytokinesis by blocking the p27(Kip1) ubiquitination pathway in hepatocellular carcinoma.
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Silencing of KIF18B restricts proliferation and invasion and enhances the chemosensitivity of breast cancer via modulating Akt/GSK-3?/?-catenin pathway.
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Silencing of KIF3B Suppresses Breast Cancer Progression by Regulating EMT and Wnt/?-Catenin Signaling.
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Simul-seq: combined DNA and RNA sequencing for whole-genome and transcriptome profiling.
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Single functionalized graphene oxide reconstitutes kinesin mediated intracellular cargo transport and delivers multiple cytoskeleton proteins and therapeutic molecules into the cell.
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Sox17 inhibits hepatocellular carcinoma progression by downregulation of KIF14 expression.
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Specific kinesin expression profiles associated with taxane resistance in basal-like breast cancer.
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STAT1-induced upregulation of lncRNA LINC01123 predicts poor prognosis and promotes the progression of endometrial cancer through miR-516b/KIF4A.
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Structural basis for inhibition of Eg5 by dihydropyrimidines: stereoselectivity of antimitotic inhibitors enastron, dimethylenastron and fluorastrol.
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Structural basis of small molecule ATPase inhibition of a human mitotic kinesin motor protein.
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Structural insights into a unique inhibitor binding pocket in kinesin spindle protein.
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Structure-activity relationship of pyrazolo pyrimidine derivatives as inhibitors of mitotic kinesin Eg5 and anticancer agents.
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Structure-activity relationship of S-trityl-l-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.
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Successful imatinib therapy for neuroendocrine carcinoma with activating Kit mutation: a case study.
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Suppression of KIF14 expression inhibits hepatocellular carcinoma progression and predicts favorable outcome.
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Suppression of KIF3A inhibits triple negative breast cancer growth and metastasis by repressing Rb-E2F signaling and epithelial-mesenchymal transition.
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Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF-? signaling.
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Synthesis and Biological Evaluation of Optimized Inhibitors of the Mitotic Kinesin Kif18A.
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Synthesis of N-(1-(6-acetamido-5-phenylpyrimidin-4-yl) piperidin-3-yl) amide derivatives as potential inhibitors for mitotic kinesin spindle protein.
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Synthetic studies of centromere-associated protein-E (CENP-E) inhibitors: 1.Exploration of fused bicyclic core scaffolds using electrostatic potential map.
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Targeted deletion of Kif18a protects from colitis-associated colorectal (CAC) tumors in mice through impairing Akt phosphorylation.
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Targeting cell cycle by ?-carboline alkaloids in vitro: Novel therapeutic prospects for the treatment of cancer.
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Targeting protein for Xenopus kinesin-like protein 2 knockdown enhances radiation sensitivity of human lung squamous carcinoma cell.
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Targeting the KIF4A/AR Axis to Reverse Endocrine Therapy Resistance in Castration-resistant Prostate Cancer.
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The ATM and ATR kinases regulate centrosome clustering and tumor recurrence by targeting KIFC1 phosphorylation.
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The clinical significance and prognostic value of Xenopus kinesin-like protein 2 expressions in human tumors: A systematic review and meta-analysis.
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The effector domain of human Dlg tumor suppressor acts as a switch that relieves autoinhibition of kinesin-3 motor GAKIN/KIF13B.
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The expression of Eg5 predicts a poor outcome for patients with renal cell carcinoma.
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The identification, purification, and characterization of a pancreatic beta-cell form of the microtubule adenosine triphosphatase kinesin.
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The kinesin KIF14 is overexpressed in medulloblastoma and downregulation of KIF14 suppressed tumor proliferation and induced apoptosis.
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The kinesin KIF1B{beta} acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor.
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The kinesin motor protein KIF4A as a potential therapeutic target in renal cell carcinoma.
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The long non-coding RNA MALAT1 promotes ovarian cancer progression by regulating RBFOX2-mediated alternative splicing.
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The mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastoma.
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The motor protein KIF14 inhibits tumor growth and cancer metastasis in lung adenocarcinoma.
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The novel combination of chlorpromazine and pentamidine exerts synergistic antiproliferative effects through dual mitotic action.
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The overexpression of KIFC1 was associated with the proliferation and prognosis of non-small cell lung cancer.
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The role of kinesin family proteins in tumorigenesis and progression: potential biomarkers and molecular targets for cancer therapy.
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The role of kinesin KIF18A in the invasion and metastasis of hepatocellular carcinoma.
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The tumour suppressor DLC2 ensures mitotic fidelity by coordinating spindle positioning and cell-cell adhesion.
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The von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2.
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TPX2 as a Novel Prognostic Indicator and Promising Therapeutic Target in Triple-negative Breast Cancer.
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TPX2 level correlates with cholangiocarcinoma cell proliferation, apoptosis, and EMT.
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Transcriptional and Epigenetic Regulation of KIF14 Overexpression in Ovarian Cancer.
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Translating bioinformatics in oncology: guilt-by-profiling analysis and identification of KIF18B and CDCA3 as novel driver genes in carcinogenesis.
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Triphenylbutanamines: Kinesin spindle protein inhibitors with in vivo antitumor activity.
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Triton X-100-Modified Adenosine Triphosphate-Responsive siRNA Delivery Agent for Antitumor Therapy.
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Tumor necrosis factor induces hyperphosphorylation of kinesin light chain and inhibits kinesin-mediated transport of mitochondria.
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Tumor suppressor KIF1B? regulates mitochondrial apoptosis in collaboration with YME1L1.
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Tumor suppressor protein p53-mediated repression of human mitotic centromere-associated kinesin gene expression is exerted via down-regulation of Sp1 level.
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Tumour Suppressor Adenomatous Polyposis Coli (APC) localisation is regulated by both Kinesin-1 and Kinesin-2.
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Up-regulation of KIF14 is a predictor of poor survival and a novel prognostic biomarker of chemoresistance to paclitaxel treatment in cervical cancer.
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Upregulate KIF4A Enhances Proliferation, Invasion of Hepatocellular Carcinoma and Indicates poor prognosis Across Human Cancer Types.
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Upregulation of KIF11 in TP53 Mutant Glioma Promotes Tumor Stemness and Drug Resistance.
Neoplasms
Upregulation of KIF20A promotes tumor proliferation and invasion in renal clear cell carcinoma and is associated with adverse clinical outcome.
Neoplasms
Upregulation of kinesin family member 4A enhanced cell proliferation via activation of Akt signaling and predicted a poor prognosis in hepatocellular carcinoma.
Neoplasms
Validating the mitotic kinesin Eg5 as a therapeutic target in pancreatic cancer cells and tumor xenografts using a specific inhibitor.
Neoplasms
Whole Exome Sequencing of Multiple Atypical Meningiomas in a Patient without History of Neurofibromatosis Type II: A Case Report.
Neoplasms
YAP/TEAD4-induced KIF4A contributes to the progression and worse prognosis of esophageal squamous cell carcinoma.
Neoplasms
ZNF367-induced transcriptional activation of KIF15 accelerates the progression of breast cancer.
Nervous System Diseases
A de novo dominant mutation in KIF1A associated with axonal neuropathy, spasticity and autism spectrum disorder.
Nervous System Diseases
Expansion of the phenotypic spectrum of de novo missense variants in kinesin family member 1A (KIF1A).
Nervous System Diseases
Genome sequencing uncovers phenocopies in primary progressive multiple sclerosis.
Nervous System Diseases
Kinesin-Binding Protein Controls Microtubule Dynamics and Cargo Trafficking by Regulating Kinesin Motor Activity.
Nervous System Diseases
Kinesins in neurological inherited diseases: a novel motor-domain mutation in KIF5A gene in a patient from Southern Italy affected by hereditary spastic paraplegia.
Nervous System Diseases
The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory.
Nervous System Diseases
The Novel KIF1A Missense Variant (R169T) Strongly Reduces Microtubule Stimulated ATPase Activity and Is Associated With NESCAV Syndrome.
Neuralgia
Tozasertib Attenuates Neuropathic Pain by Interfering with Aurora Kinase and KIF11 Mediated Nociception.
Neuritis
Disruption of Fast Axonal Transport in the Rat Induces Behavioral Changes Consistent With Neuropathic Pain.
Neuroaxonal Dystrophies
Axonal spheroids in ovine neuroaxonal dystrophy are immunopositive to kinesin and dynein.
Neuroblastoma
A germline mutation of the KIF1B beta gene on 1p36 in a family with neural and nonneural tumors.
Neuroblastoma
Age related gene DST represents an independent prognostic factor for MYCN non-amplified neuroblastoma.
Neuroblastoma
Differential expression of minimal residual disease markers in peripheral blood and bone marrow samples from high-risk neuroblastoma patients.
Neuroblastoma
Differential expression of ubiquitous and neuronal kinesin heavy chains during differentiation of human neuroblastoma and PC12 cells.
Neuroblastoma
Early detection of tumor relapse/regrowth by consecutive minimal residual disease monitoring in high-risk neuroblastoma patients.
Neuroblastoma
Expression of KIF3C kinesin during neural development and in vitro neuronal differentiation.
Neuroblastoma
Genetic predisposition to neural crest-derived tumors: revisiting the role of KIF1B.
Neuroblastoma
Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2.
Neuroblastoma
Human kinesin light (beta) chain gene: DNA sequence and functional characterization of its promoter and first exon.
Neuroblastoma
KIF5C: a new binding partner for protein kinase CK2 with a preference for the CK2alpha' subunit.
Neuroblastoma
Minimal residual disease monitoring in neuroblastoma patients based on the expression of a set of real-time RT-PCR markers in tumor-initiating cells.
Neuroblastoma
Mobility of the von Hippel-Lindau tumour suppressor protein is regulated by kinesin-2.
Neuroblastoma
Neuroblast differentiation during development and in neuroblastoma requires KIF1B?-mediated transport of TRKA.
Neuroblastoma
RNA Helicase A Is a Downstream Mediator of KIF1B? Tumor-Suppressor Function in Neuroblastoma.
Neuroblastoma
Therapeutic targeting of KSP in preclinical models of high-risk neuroblastoma.
Neuroblastoma
Tumor suppressor KIF1B? regulates mitochondrial apoptosis in collaboration with YME1L1.
Neuroblastoma
XAF1 promotes neuroblastoma tumor suppression and is required for KIF1B?-mediated apoptosis.
Neurodegenerative Diseases
Autosomal dominant transmission of complicated hereditary spastic paraplegia due to a dominant negative mutation of KIF1A, SPG30 gene.
Neurodegenerative Diseases
Axonal spheroids in ovine neuroaxonal dystrophy are immunopositive to kinesin and dynein.
Neurodegenerative Diseases
Axonal transport and neurodegenerative disease: vesicle-motor complex formation and their regulation.
Neurodegenerative Diseases
Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease.
Neurodegenerative Diseases
Generation of a human induced pluripotent stem cell line (SDUBMSi001-A) from a hereditary spastic paraplegia patient carrying kif1a c.773C>T missense mutation.
Neurodegenerative Diseases
Heterozygous KIF1A variants underlie a wide spectrum of neurodevelopmental and neurodegenerative disorders.
Neurodegenerative Diseases
Kinesin and dynein mechanics: measurement methods and research applications.
Neurodegenerative Diseases
Monoallelic KIF1A-related disorders: a multicenter cross sectional study and systematic literature review.
Neurodegenerative Diseases
Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking.
Neurodegenerative Diseases
Polyglutamylation of tubulin's C-terminal tail controls pausing and motility of kinesin-3 family member KIF1A.
Neurodegenerative Diseases
Reductions in kinesin expression are associated with nitric oxide-induced axonal damage.
Neurodegenerative Diseases
Rotenone-dependent changes of anterograde motor protein expression and mitochondrial mobility in brain areas related to neurodegenerative diseases.
Neurodegenerative Diseases
Tau excess impairs mitosis and kinesin-5 function, leading to aneuploidy and cell death.
Neurodegenerative Diseases
Temporal and tissue specific gene expression patterns of the zebrafish kinesin-1 heavy chain family, kif5s, during development.
Neurodegenerative Diseases
Variants in KIF1A gene in dominant and sporadic forms of hereditary spastic paraparesis.
Neurodegenerative Diseases
[Intracellular transport proteins: classification, structure and function of kinesins].
Neurofibromatoses
The motor protein kinesin-1 links neurofibromin and merlin in a common cellular pathway of neurofibromatosis.
Neurofibrosarcoma
KIF11 and KIF15 mitotic kinesins are potential therapeutic vulnerabilities for malignant peripheral nerve sheath tumors.
Neurologic Manifestations
Dominant transmission of de novo KIF1A motor domain variant underlying pure spastic paraplegia.
Non-alcoholic Fatty Liver Disease
miR-122-5p/KIF5B/AMPK/AKT regulatory network regulates the progression of NAFLD.
Obesity
Adipose-specific deletion of Kif5b exacerbates obesity and insulin resistance in a mouse model of diet-induced obesity.
Obesity
First Report of a de novo 10q23.31q23.33 Microdeletion: Obesity, Intellectual Disability and Microcephaly.
Obesity
Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus.
Ocular Motility Disorders
Human CFEOM1 Mutations Attenuate KIF21A Autoinhibition and Cause Oculomotor Axon Stalling.
Oculomotor Nerve Diseases
Congenital fibrosis of extraocular muscles type 1 with progression of ophthalmoplegia.
Oligodendroglioma
Mutational study of the 1p located genes p18ink4c, Patched-2, RIZ1 and KIF1B in oligodendrogliomas.
Optic Nerve Hypoplasia
Optic nerve hypoplasia in a patient with a de novo KIF1A heterozygous mutation.
Orchitis
Identification of Orch3, a locus controlling dominant resistance to autoimmune orchitis, as kinesin family member 1C.
Osteoporosis
Clinical and molecular characterization of familial exudative vitreoretinopathy associated with microcephaly.
Osteosarcoma
Circular RNA circ_0032462 Enhances Osteosarcoma Cell Progression by Promoting KIF3B Expression.
Osteosarcoma
Identification of KIF4A as a pan-cancer diagnostic and prognostic biomarker via bioinformatics analysis and validation in osteosarcoma cell lines.
Osteosarcoma
Identification of Kinesin Family Member 2A (KIF2A) as a Promising Therapeutic Target for Osteosarcoma.
Osteosarcoma
Kinesins in MAPK cascade: How kinesin motors are involved in the MAPK pathway?
Osteosarcoma
Knockdown of Kinesin Family 15 Inhibits Osteosarcoma through Suppressing Cell Proliferation and Promoting Cell Apoptosis.
Osteosarcoma
Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10.
Ovarian Neoplasms
A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian adenocarcinomas.
Ovarian Neoplasms
Bioinformatics Analysis of KIF1A Expression and Gene Regulation Network in Ovarian Carcinoma.
Ovarian Neoplasms
Clinical relevance of cytoskeleton associated proteins for ovarian cancer.
Ovarian Neoplasms
Cyclin F and KIF20A, FOXM1 target genes, increase proliferation and invasion of ovarian cancer cells.
Ovarian Neoplasms
Identification of an energy metabolism?related gene signature in ovarian cancer prognosis.
Ovarian Neoplasms
Identification of candidate biomarkers and analysis of prognostic values in ovarian cancer by integrated bioinformatics analysis.
Ovarian Neoplasms
Identification of Differentially Expressed Genes (DEGs) Relevant to Prognosis of Ovarian Cancer by Use of Integrated Bioinformatics Analysis and Validation by Immunohistochemistry Assay.
Ovarian Neoplasms
Identification of the Hub Genes Associated with the Prognosis of Ovarian Cancer Patients via Integrated Bioinformatics Analysis and Experimental Validation.
Ovarian Neoplasms
Increased expression of KPNA2 predicts unfavorable prognosis in ovarian cancer patients, possibly by targeting KIF4A signaling.
Ovarian Neoplasms
Integrative analysis of key candidate genes and signaling pathways in ovarian cancer by bioinformatics.
Ovarian Neoplasms
KIF4A knockdown suppresses ovarian cancer cell proliferation and induces apoptosis by downregulating BUB1 expression.
Ovarian Neoplasms
KIFCI, a novel putative prognostic biomarker for ovarian adenocarcinomas: delineating protein interaction networks and signaling circuitries.
Ovarian Neoplasms
Kinesin family member 14: An independent prognostic marker and potential therapeutic target for ovarian cancer.
Ovarian Neoplasms
Kinesin Family Member C1 (KIFC1) Regulated by Centrosome Protein E (CENPE) Promotes Proliferation, Migration, and Epithelial-Mesenchymal Transition of Ovarian Cancer.
Ovarian Neoplasms
Knockdown of KIF15 promotes cell apoptosis by activating crosstalk of multiple pathways in ovarian cancer: bioinformatic and experimental analysis.
Ovarian Neoplasms
miR-29c-3p regulates proliferation and migration in ovarian cancer by targeting KIF4A.
Ovarian Neoplasms
Overexpression of KIF2A is Suppressed by miR-206 and Associated with Poor Prognosis in Ovarian Cancer.
Ovarian Neoplasms
Prognostic and clinicopathological significance of kinesin family member C1 in various cancers: A meta-analysis.
Ovarian Neoplasms
Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma.
Pancreatic Diseases
A Novel Synergistic Association of Variants in PTRH2 and KIF1A Relates to a Syndrome of Hereditary Axonopathy, Outer Hair Cell Dysfunction, Intellectual Disability, Pancreatic Lipomatosis, Diabetes, Cerebellar Atrophy, and Vertebral Artery Hypoplasia.
Pancreatic Neoplasms
A phase I clinical trial of vaccination with KIF20A-derived peptide in combination with gemcitabine for patients with advanced pancreatic cancer.
Pancreatic Neoplasms
Associations between genetic variants of KIF5B, FMN1, and MGAT3 in the cadherin pathway and pancreatic cancer risk.
Pancreatic Neoplasms
Characterization of Novel Diaryloxazole-Based Compounds as Potential Agents to Treat Pancreas Cancer.
Pancreatic Neoplasms
Dimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5.
Pancreatic Neoplasms
Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell.
Pancreatic Neoplasms
Functional analysis of KIF20A, a potential immunotherapeutic target for glioma.
Pancreatic Neoplasms
Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer.
Pancreatic Neoplasms
Increased KIF15 Expression Predicts a Poor Prognosis in Patients with Lung Adenocarcinoma.
Pancreatic Neoplasms
KIF15 promotes pancreatic cancer proliferation via the MEK-ERK signalling pathway.
Pancreatic Neoplasms
KIF20A-mediated RNA granule transport system promotes the invasiveness of pancreatic cancer cells.
Pancreatic Neoplasms
Kinesin 12 (KIF15) contributes to the development and tumorigenicity of prostate cancer.
Pancreatic Neoplasms
Phase I/II clinical trial using HLA-A24-restricted peptide vaccine derived from KIF20A for patients with advanced pancreatic cancer.
Pancreatic Neoplasms
Positive expression of KIF20A indicates poor prognosis of glioma patients.
Pancreatic Neoplasms
Validating the mitotic kinesin Eg5 as a therapeutic target in pancreatic cancer cells and tumor xenografts using a specific inhibitor.
Pancreatitis
The potential role of kinesin and dynein in Golgi scattering and cytoplasmic vacuole formation during acute experimental pancreatitis.
Paraganglioma
KIF1B and NF1 are the most frequently mutated genes in paraganglioma and pheochromocytoma tumors.
Paraganglioma
Whole Exome Sequencing Identifies Novel Genetic Alterations in Patients with Pheochromocytoma/Paraganglioma.
Paralysis
APLIP1, a kinesin binding JIP-1/JNK scaffold protein, influences the axonal transport of both vesicles and mitochondria in Drosophila.
Paralysis
Congenital fibrosis of extraocular muscles type 1 with progression of ophthalmoplegia.
Paralysis
Cytoplasmic dynein, the dynactin complex, and kinesin are interdependent and essential for fast axonal transport.
Paralysis
Identification of an Axonal Kinesin-3 Motor for Fast Anterograde Vesicle Transport that Facilitates Retrograde Transport of Neuropeptides.
Paralysis
Kinesin heavy chain function in Drosophila glial cells controls neuronal activity.
Paraparesis, Spastic
A missense mutation in the coiled-coil domain of the KIF5A gene and late-onset hereditary spastic paraplegia.
Paraparesis, Spastic
A novel KIF5A mutation in an Italian family marked by spastic paraparesis and congenital deafness.
Paraparesis, Spastic
Altered CSF levels of monoamines in hereditary spastic paraparesis 10: A case series.
Paraparesis, Spastic
De novo mutations in the motor domain of KIF1A cause cognitive impairment, spastic paraparesis, axonal neuropathy, and cerebellar atrophy.
Paraparesis, Spastic
Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis.
Paraparesis, Spastic
KIF5A and ALS2 Variants in a Family With Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis.
Paraparesis, Spastic
Usefulness of exome sequencing in the study of spastic paraparesis and cerebellar atrophy: De novo mutation of the KIF1A gene, a new hope in prognosis.
Paraparesis, Spastic
Variants in KIF1A gene in dominant and sporadic forms of hereditary spastic paraparesis.
Paraplegia
A de novo dominant mutation in KIF1A associated with axonal neuropathy, spasticity and autism spectrum disorder.
Paraplegia
A Novel de novo KIF1A Mutation in a Patient with Autism, Hyperactivity, Epilepsy, Sensory Disturbance, and Spastic Paraplegia.
Paraplegia
A novel KIF5a mutation identified in two-family members with spastic paraplegia type 10.
Paraplegia
A novel mutation in KIF5A in a Malian family with spastic paraplegia and sensory loss.
Paraplegia
Dominant transmission of de novo KIF1A motor domain variant underlying pure spastic paraplegia.
Paraplegia
Extended phenotypic spectrum of KIF5A mutations: From spastic paraplegia to axonal neuropathy.
Paraplegia
Genome sequencing uncovers phenocopies in primary progressive multiple sclerosis.
Paraplegia
Heterozygous KIF1A variants underlie a wide spectrum of neurodevelopmental and neurodegenerative disorders.
Paraplegia
Identification of two novel KIF5A mutations in hereditary spastic paraplegia associated with mild peripheral neuropathy.
Paraplegia
KIF1A missense mutations in SPG30, an autosomal recessive spastic paraplegia: distinct phenotypes according to the nature of the mutations.
Paraplegia
KIF1A variants are a frequent cause of autosomal dominant hereditary spastic paraplegia.
Paraplegia
KIF1A-related autosomal dominant spastic paraplegias (SPG30) in Russian families.
Paraplegia
KIF5A de novo mutation associated with myoclonic seizures and neonatal onset progressive leukoencephalopathy.
Paraplegia
KIF5A mutations cause an infantile onset phenotype including severe myoclonus with evidence of mitochondrial dysfunction.
Paraplegia
Kinesins in neurological inherited diseases: a novel motor-domain mutation in KIF5A gene in a patient from Southern Italy affected by hereditary spastic paraplegia.
Paraplegia
Mobility Characteristics of Children with Spastic Paraplegia Due to a Mutation in the KIF1A Gene.
Paraplegia
Mutation in KIF5A c.610C>T Causing Hereditary Spastic Paraplegia with Axonal Sensorimotor Neuropathy.
Paraplegia
Mutations in the motor and stalk domains of KIF5A in spastic paraplegia type 10 and in axonal Charcot-Marie-Tooth type 2.
Paraplegia
Phenotypic Expansion in KIF1A-related Dominant Disorders: A Description of Novel Variants and Review of Published Cases.
Paraplegia
Role of Kinesin-1 in the Pathogenesis of SPG10, a Rare Form of Hereditary Spastic Paraplegia.
Paraplegia
Spastic paraplegia mutation N256S in the neuronal microtubule motor KIF5A disrupts axonal transport in a Drosophila HSP model.
Paraplegia
Targeted high throughput sequencing in hereditary ataxia and spastic paraplegia.
Paraplegia
The novel de novo mutation of KIF1A gene as the cause for Spastic paraplegia 30 in a Japanese case.
Parkinson Disease
Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease.
Parkinsonian Disorders
Whole exome sequencing and the clinician: we need clinical skills and functional validation in variant filtering.
Pemphigoid, Bullous
[Comparison of urinary proteomics between steroid-sensitive and steroid-resistant minimal change nephrotic syndrome in children.]
Peripheral Nervous System Diseases
A Database of Caenorhabditis elegans Locomotion and Body Posture Phenotypes for the Peripheral Neuropathy Model.
Peripheral Nervous System Diseases
Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins.
Peripheral Nervous System Diseases
Charcot-Marie-Tooth disease and related neuropathies: mutation distribution and genotype-phenotype correlation.
Peripheral Nervous System Diseases
De novo mutations in the motor domain of KIF1A cause cognitive impairment, spastic paraparesis, axonal neuropathy, and cerebellar atrophy.
Peripheral Nervous System Diseases
Effects of eribulin, vincristine, paclitaxel and ixabepilone on fast axonal transport and kinesin-1 driven microtubule gliding: implications for chemotherapy-induced peripheral neuropathy.
Peripheral Nervous System Diseases
Hippocampal to basal forebrain transport of Mn(2+) is impaired by deletion of KLC1, a subunit of the conventional kinesin microtubule-based motor.
Peripheral Nervous System Diseases
Identification of two novel KIF5A mutations in hereditary spastic paraplegia associated with mild peripheral neuropathy.
Peripheral Nervous System Diseases
The Effects of Combined Exercise Training (Resistance-Aerobic) on Serum Kinesin and Physical Function in Type 2 Diabetes Patients with Diabetic Peripheral Neuropathy (Randomized Controlled Trials).
Peripheral Nervous System Diseases
Wide phenotypic spectrum in axonal Charcot-Marie-Tooth neuropathy type 2 patients with KIF5A mutations.
Pheochromocytoma
A germline mutation of the KIF1B beta gene on 1p36 in a family with neural and nonneural tumors.
Pheochromocytoma
Genetic predisposition to neural crest-derived tumors: revisiting the role of KIF1B.
Pheochromocytoma
KIF1B and NF1 are the most frequently mutated genes in paraganglioma and pheochromocytoma tumors.
Pheochromocytoma
RNA Helicase A Is a Downstream Mediator of KIF1B? Tumor-Suppressor Function in Neuroblastoma.
Pheochromocytoma
Tumor suppressor KIF1B? regulates mitochondrial apoptosis in collaboration with YME1L1.
Plasmacytoma
Chromosome 8q as the most frequent target for amplification in early gastric carcinoma.
plus-end-directed kinesin atpase deficiency
A novel role of the chromokinesin Kif4A in DNA damage response.
plus-end-directed kinesin atpase deficiency
Amyloid beta-mediated KIF5A deficiency disrupts anterograde axonal mitochondrial movement.
plus-end-directed kinesin atpase deficiency
An orphan kinesin in trypanosomes cooperates with a kinetoplastid-specific kinesin to maintain cell morphology through regulating subpellicular microtubules.
plus-end-directed kinesin atpase deficiency
Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis.
plus-end-directed kinesin atpase deficiency
Kif18a is specifically required for mitotic progression during germ line development.
plus-end-directed kinesin atpase deficiency
Kif3a controls murine nephron number via GLI3 repressor, cell survival, and gene expression in a lineage-specific manner.
plus-end-directed kinesin atpase deficiency
Kif3a deficiency reverses the skeletal abnormalities in Pkd1 deficient mice by restoring the balance between osteogenesis and adipogenesis.
plus-end-directed kinesin atpase deficiency
Kinesin-5 Is Dispensable for Bipolar Spindle Formation and Elongation in Candida albicans, but Simultaneous Loss of Kinesin-14 Activity Is Lethal.
plus-end-directed kinesin atpase deficiency
Small molecule suppressors of Drosophila Kinesin deficiency rescue motor axon development in a zebrafish model of spinal muscular atrophy.
plus-end-directed kinesin atpase deficiency
Suppressor Analysis Uncovers That MAPs and Microtubule Dynamics Balance with the Cut7/Kinesin-5 Motor for Mitotic Spindle Assembly in Schizosaccharomyces pombe.
Polycystic Kidney Diseases
Col2-Cre recombinase is co-expressed with endogenous type II collagen in embryonic renal epithelium and drives development of polycystic kidney disease following inactivation of ciliary genes.
Polycystic Kidney Diseases
HNF-1beta regulates transcription of the PKD modifier gene Kif12.
Polycystic Kidney Diseases
Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease.
Polycystic Kidney Diseases
Kinesin family member 12 is a candidate polycystic kidney disease modifier in the cpk mouse.
Polycystic Kidney Diseases
Polycystin-2 cation channel function is under the control of microtubular structures in primary cilia of renal epithelial cells.
Polycystic Kidney Diseases
Restoration of proximal tubule flow-activated transport prevents cyst growth in polycystic kidney disease.
Polydactyly
Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms.
Polyneuropathies
Hereditary Spastic Paraplegia with Axonal Sensorimotor Polyneuropathy in a Korean Family Caused by Pathogenic Variant of KIF5A (c.611G>A).
Polyneuropathies
Progressive Lower Extremity Weakness and Axonal Sensorimotor Polyneuropathy from a Mutation in KIF5A (c.611G>A;p.Arg204Gln).
Prion Diseases
Deletion of Kif5c Does Not Alter Prion Disease Tempo or Spread in Mouse Brain.
Prostatic Neoplasms
AIM1 promoter hypermethylation as a predictor of decreased risk of recurrence following radical prostatectomy.
Prostatic Neoplasms
An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer.
Prostatic Neoplasms
Androgens modify therapeutic response to cabazitaxel in models of advanced prostate cancer.
Prostatic Neoplasms
Effects of KIF2A on the prognosis of nasopharyngeal carcinoma and nasopharyngeal carcinoma cells.
Prostatic Neoplasms
Expression of KIF18A Is Associated with Increased Tumor Stage and Cell Proliferation in Prostate Cancer.
Prostatic Neoplasms
Growth arrest and apoptosis induced by kinesin Eg5 inhibitor K858 and by its 1,3,4-thiadiazoline analogue in tumor cells.
Prostatic Neoplasms
High KIFC1 expression is associated with poor prognosis in prostate cancer.
Prostatic Neoplasms
Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer.
Prostatic Neoplasms
Increased KIF4A expression is a potential prognostic factor in prostate cancer.
Prostatic Neoplasms
Inhibition of kinesin motor protein KIFC1 by AZ82 induces multipolar mitosis and apoptosis in prostate cancer cell.
Prostatic Neoplasms
KIF15-Mediated Stabilization of AR and AR-V7 Contributes to Enzalutamide Resistance in Prostate Cancer.
Prostatic Neoplasms
KIF3a Promotes Proliferation and Invasion via Wnt Signaling in Advanced Prostate Cancer.
Prostatic Neoplasms
KIF3B protein expression loss correlates with metastatic ability of prostate cancer.
Prostatic Neoplasms
KIF4A: A potential biomarker for prediction and prognostic of prostate cancer.
Prostatic Neoplasms
KIF7 attenuates prostate tumor growth through LKB1-mediated AKT inhibition.
Prostatic Neoplasms
KIFC1 induces resistance to docetaxel and is associated with survival of patients with prostate cancer.
Prostatic Neoplasms
KIFC1 Inhibitor CW069 Induces Apoptosis and Reverses Resistance to Docetaxel in Prostate Cancer.
Prostatic Neoplasms
Kinesin 12 (KIF15) contributes to the development and tumorigenicity of prostate cancer.
Prostatic Neoplasms
Kinesin Family Member 11 mRNA Expression Predicts Prostate Cancer Aggressiveness.
Prostatic Neoplasms
Kinesin family member 18B regulates the proliferation and invasion of human prostate cancer cells.
Prostatic Neoplasms
METTL3-mediated m6A modification of KIF3C-mRNA promotes prostate cancer progression and is negatively regulated by miR-320d.
Prostatic Neoplasms
Mitosis phase enrichment with identification of mitotic centromere-associated Kinesin as a therapeutic target in castration-resistant prostate cancer.
Prostatic Neoplasms
Southwest Oncology Group Phase II Study of Ispinesib in Androgen-Independent Prostate Cancer Previously Treated with Taxanes.
Prostatic Neoplasms
Targeting the KIF4A/AR Axis to Reverse Endocrine Therapy Resistance in Castration-resistant Prostate Cancer.
Pseudorabies
A kinesin-3 recruitment complex facilitates axonal sorting of enveloped alpha herpesvirus capsids.
Pseudorabies
Common Features Between Stroke Following Varicella in Children and Stroke Following Herpes Zoster in Adults : Varicella-Zoster Virus in Trigeminal Ganglion.
Pseudorabies
Deletion of the Pseudorabies Virus gE/gI-US9p complex disrupts kinesin KIF1A and KIF5C recruitment during egress, and alters the properties of microtubule-dependent transport in vitro.
Pseudorabies
Pseudorabies Virus Infection Accelerates Degradation of the Kinesin-3 Motor KIF1A.
receptor protein-tyrosine kinase deficiency
KIF16B/Rab14 molecular motor complex is critical for early embryonic development by transporting FGF receptor.
Renal Insufficiency
Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia.
Reperfusion Injury
Compound porcine cerebroside and ganglioside injection attenuates cerebral ischemia-reperfusion injury in rats by targeting multiple cellular processes.
Retinal Degeneration
Abnormal photoreceptor outer segment development and early retinal degeneration in kif3a mutant zebrafish.
Retinal Degeneration
Kinesin-2 and photoreceptor cell death: requirement of motor subunits.
Retinal Degeneration
Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy.
Retinal Degeneration
Novel Insights Into the Phenotypical Spectrum of KIF11-Associated Retinopathy, Including a New Form of Retinal Ciliopathy.
Retinal Detachment
KIF11 mutations are a common cause of autosomal dominant familial exudative vitreoretinopathy.
Retinal Detachment
Phenotypic overlap between familial exudative vitreoretinopathy and microcephaly, lymphedema, and chorioretinal dysplasia caused by KIF11 mutations.
Retinal Diseases
Genotype Phenotype Correlation and Variability in Microcephaly Associated With Chorioretinopathy or Familial Exudative Vitreoretinopathy.
Retinal Dystrophies
Novel Insights Into the Phenotypical Spectrum of KIF11-Associated Retinopathy, Including a New Form of Retinal Ciliopathy.
Retinitis Pigmentosa
Mutations in the Kinesin-2 Motor KIF3B Cause an Autosomal-Dominant Ciliopathy.
Retinoblastoma
Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14.
Rett Syndrome
Expansion of the phenotypic spectrum of de novo missense variants in kinesin family member 1A (KIF1A).
Rhinitis, Allergic
KIF3A genetic variation is associated with pediatric asthma in the presence of eczema independent of allergic rhinitis.
Scleroderma, Systemic
The centromere kinesin-like protein, CENP-E. An autoantigen in systemic sclerosis.
Seizures
A Rare KIF1A Missense Mutation Enhances Synaptic Function and Increases Seizure Activity.
Seizures
Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans.
Seizures
First Report of a de novo 10q23.31q23.33 Microdeletion: Obesity, Intellectual Disability and Microcephaly.
Seizures
KIF5A de novo mutation associated with myoclonic seizures and neonatal onset progressive leukoencephalopathy.
Seizures
KIF5A-dependent axonal transport deficiency disrupts autophagic flux in trimethyltin chloride-induced neurotoxicity.
Seizures
prickle modulates microtubule polarity and axonal transport to ameliorate seizures in flies.
Seminoma
C-terminal kinesin motor KIFC1 participates in facilitating proper cell division of human seminoma.
Sertoli Cell-Only Syndrome
Germinal Cell Aplasia in Kif18a Mutant Male Mice Due to Impaired Chromosome Congression and Dysregulated BubR1 and CENP-E.
Silicosis
Silica Perturbs Primary Cilia and Causes Myofibroblast Differentiation during Silicosis by Reduction of the KIF3A-Repressor GLI3 Complex.
Situs Inversus
Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II.
Spasms, Infantile
Preliminary report for Epilepsia Open A case of West syndrome with severe global developmental delay and confirmed KIF5A gene variant.
Spastic Paraplegia, Hereditary
A de novo dominant mutation in KIF1A associated with axonal neuropathy, spasticity and autism spectrum disorder.
Spastic Paraplegia, Hereditary
A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10).
Spastic Paraplegia, Hereditary
A missense mutation in the coiled-coil domain of the KIF5A gene and late-onset hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
A novel mutation in KIF5A gene causing hereditary spastic paraplegia with axonal neuropathy.
Spastic Paraplegia, Hereditary
A Novel Mutation in Motor Domain of KIF5A Associated With an HSP/Axonal Neuropathy Phenotype.
Spastic Paraplegia, Hereditary
A Novel Mutation in the Stalk Domain of KIF5A Causes a Slowly Progressive Atypical Motor Syndrome.
Spastic Paraplegia, Hereditary
A Rare KIF1A Missense Mutation Enhances Synaptic Function and Increases Seizure Activity.
Spastic Paraplegia, Hereditary
Autosomal dominant transmission of complicated hereditary spastic paraplegia due to a dominant negative mutation of KIF1A, SPG30 gene.
Spastic Paraplegia, Hereditary
Characterization of kinesin switch I mutations that cause hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Disease-associated mutations hyperactivate KIF1A motility and anterograde axonal transport of synaptic vesicle precursors.
Spastic Paraplegia, Hereditary
Evidence of kinesin heavy chain (KIF5A) involvement in pure hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Extended phenotypic spectrum of KIF5A mutations: From spastic paraplegia to axonal neuropathy.
Spastic Paraplegia, Hereditary
Generation of a human induced pluripotent stem cell line (SDUBMSi001-A) from a hereditary spastic paraplegia patient carrying kif1a c.773C>T missense mutation.
Spastic Paraplegia, Hereditary
Genotype-phenotype correlations of KIF5A stalk domain variants.
Spastic Paraplegia, Hereditary
Going Too Far Is the Same as Falling Short: Kinesin-3 Family Members in Hereditary Spastic Paraplegia.
Spastic Paraplegia, Hereditary
Hereditary spastic paraplegia caused by compound heterozygous mutations outside the motor domain of the KIF1A gene.
Spastic Paraplegia, Hereditary
Hereditary Spastic Paraplegia with Axonal Sensorimotor Polyneuropathy in a Korean Family Caused by Pathogenic Variant of KIF5A (c.611G>A).
Spastic Paraplegia, Hereditary
Identification of two novel KIF5A mutations in hereditary spastic paraplegia associated with mild peripheral neuropathy.
Spastic Paraplegia, Hereditary
KIF1A variants are a frequent cause of autosomal dominant hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
KIF5A and ALS2 Variants in a Family With Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis.
Spastic Paraplegia, Hereditary
Kinesins in neurological inherited diseases: a novel motor-domain mutation in KIF5A gene in a patient from Southern Italy affected by hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Late-onset spastic paraplegia type 10 (SPG10) family presenting with bulbar symptoms and fasciculations mimicking amyotrophic lateral sclerosis.
Spastic Paraplegia, Hereditary
Long-term follow-up until early adulthood in autosomal dominant, complex SPG30 with a novel KIF1A variant: a case report.
Spastic Paraplegia, Hereditary
Mobility Characteristics of Children with Spastic Paraplegia Due to a Mutation in the KIF1A Gene.
Spastic Paraplegia, Hereditary
Molecular analysis and clinical diversity of distal hereditary motor neuropathy.
Spastic Paraplegia, Hereditary
Mutation in KIF5A c.610C>T Causing Hereditary Spastic Paraplegia with Axonal Sensorimotor Neuropathy.
Spastic Paraplegia, Hereditary
Mutation in KIF5A can also cause adult-onset hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Mutations in the motor and stalk domains of KIF5A in spastic paraplegia type 10 and in axonal Charcot-Marie-Tooth type 2.
Spastic Paraplegia, Hereditary
Novel De Novo Mutations in KIF1A as a Cause of Hereditary Spastic Paraplegia With Progressive Central Nervous System Involvement.
Spastic Paraplegia, Hereditary
Novel SPG10 mutation associated with dysautonomia, spinal cord atrophy, and skin biopsy abnormality.
Spastic Paraplegia, Hereditary
Role of Kinesin-1 in the Pathogenesis of SPG10, a Rare Form of Hereditary Spastic Paraplegia.
Spastic Paraplegia, Hereditary
SPG10 is a rare cause of spastic paraplegia in European families.
Spastic Paraplegia, Hereditary
Structural consequences of hereditary spastic paraplegia disease-related mutations in kinesin.
Spastic Paraplegia, Hereditary
Sural biopsy to detect the axonal cytoskeleton defects in KIF5A-related Charcot-Marie-Tooth disease type 2.
Spastic Paraplegia, Hereditary
Temporal and tissue specific gene expression patterns of the zebrafish kinesin-1 heavy chain family, kif5s, during development.
Spastic Paraplegia, Hereditary
The Drosophila KIF1A Homolog unc-104 Is Important for Site-Specific Synapse Maturation.
Spastic Paraplegia, Hereditary
The novel de novo mutation of KIF1A gene as the cause for Spastic paraplegia 30 in a Japanese case.
Spastic Paraplegia, Hereditary
Theoretical Investigations of the Role of Mutations in Dynamics of Kinesin Motor Proteins.
Spastic Paraplegia, Hereditary
Three routes to suppression of the neurodegenerative phenotypes caused by Kinesin heavy chain mutations.
Spastic Paraplegia, Hereditary
Unique function of Kinesin Kif5A in localization of mitochondria in axons.
Spastic Paraplegia, Hereditary
Whole exome sequencing and the clinician: we need clinical skills and functional validation in variant filtering.
Spastic Paraplegia, Hereditary
Wide phenotypic spectrum in axonal Charcot-Marie-Tooth neuropathy type 2 patients with KIF5A mutations.
Spastic Paraplegia, Hereditary
[Intracellular transport proteins: classification, structure and function of kinesins].
Spinal Cord Injuries
Pharmacologically inhibiting kinesin-5 activity with monastrol promotes axonal regeneration following spinal cord injury.
Spinal Cord Injuries
Temporal and spatial expression of KIF3B after acute spinal cord injury in adult rats.
Spinocerebellar Ataxias
Co-existence of spastic paraplegia-30 with novel KIF1A mutation and spinocerebellar ataxia 31 with intronic expansion of BEAN and TK2 in a family.
Squamous Cell Carcinoma of Head and Neck
Expression of Kif5b protein is significantly associated with the progression, recurrence and prognosis of oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
KIF1A and EDNRB are differentially methylated in primary HNSCC and salivary rinses.
Squamous Cell Carcinoma of Head and Neck
Kinesin family member 4A: a potential predictor for progression of human oral cancer.
Squamous Cell Carcinoma of Head and Neck
MiR-127-3p targets KIF3B to inhibit the development of oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
[Analysis of key genes and signal pathways of human papilloma virus-related head and neck squamous cell carcinoma].
Starvation
Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1.
Starvation
Somatic insulin signaling regulates a germline starvation response in Drosophila egg chambers.
Stomach Neoplasms
CDK6 is stimulated by hyperthermia and protects gastric cancer cells from hyperthermia?induced damage.
Stomach Neoplasms
Clinical utility of measuring expression levels of KAP1, TIMP1 and STC2 in peripheral blood of patients with gastric cancer.
Stomach Neoplasms
Clinicopathological and biological significance of mitotic centromere-associated kinesin overexpression in human gastric cancer.
Stomach Neoplasms
FOXM1 mediates resistance to docetaxel in gastric cancer via up-regulating Stathmin.
Stomach Neoplasms
High KIF2A expression promotes proliferation, migration and predicts poor prognosis in lung adenocarcinoma.
Stomach Neoplasms
Identification of kinesin family member 3B (KIF3B) as a molecular target for gastric cancer.
Stomach Neoplasms
Increased expression levels of AURKA and KIFC1 are promising predictors of progression and poor survival associated with gastric cancer.
Stomach Neoplasms
KIF15 facilitates gastric cancer via enhancing proliferation, inhibiting apoptosis, and predict poor prognosis.
Stomach Neoplasms
KIF15 promotes the evolution of gastric cancer cells through inhibition of reactive oxygen species-mediated apoptosis.
Stomach Neoplasms
KIF1B promotes glioma migration and invasion via cell surface localization of MT1-MMP.
Stomach Neoplasms
KIF23 activated Wnt/?-catenin signaling pathway through direct interaction with Amer1 in gastric cancer.
Stomach Neoplasms
KIF23 enhances cell proliferation in pancreatic ductal adenocarcinoma and is a potent therapeutic target.
Stomach Neoplasms
KIF26B, a novel oncogene, promotes proliferation and metastasis by activating the VEGF pathway in gastric cancer.
Stomach Neoplasms
Kinesin Eg5 Targeting Inhibitors as a New Strategy for Gastric Adenocarcinoma Treatment.
Stomach Neoplasms
Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion.
Stomach Neoplasms
miR-135a acts as a tumor suppressor in gastric cancer in part by targeting KIFC1.
Stomach Neoplasms
Overexpression of KIF11 in Gastric Cancer with Intestinal Mucin Phenotype.
Stomach Neoplasms
Overexpression of KIFC1 and its association with spheroid formation in esophageal squamous cell carcinoma.
Stomach Neoplasms
[Expression of KIF18A in gastric cancer and its association with prognosis].
Stroke
A simulation model of the conventional kinesin based on the Driven-by-Detachment mechanism.
Stroke
KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise.
Stroke
Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd.
Stroke
Multiscale Coarse-Grained Model for the Stepping of Molecular Motors with Application to Kinesin.
Stroke
Prometaphase spindle maintenance by an antagonistic motor-dependent force balance made robust by a disassembling lamin-B envelope.
Stroke
Structural basis for power stroke vs. Brownian ratchet mechanisms of motor proteins.
Stroke
Two conformations in the human kinesin power stroke defined by X-ray crystallography and EPR spectroscopy.
Tauopathies
Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies.
Teratozoospermia
Decreased Expression of KIFC1 in Human Testes with Globozoospermic Defects.
Testicular Neoplasms
C-terminal kinesin motor KIFC1 participates in facilitating proper cell division of human seminoma.
Tetanus
Myosin Va and microtubule-based motors are required for fast axonal retrograde transport of tetanus toxin in motor neurons.
Thrombosis
High KIF18A expression correlates with unfavorable prognosis in primary hepatocellular carcinoma.
Thyroid Neoplasms
Effects of small interfering RNA-mediated silencing of susceptibility genes of non-syndromic cleft lip with or without cleft palate on cell proliferation and migration.
Thyroid Neoplasms
Loss of primary cilia promotes mitochondria-dependent apoptosis in thyroid cancer.
Tics
Minimal residual disease monitoring in neuroblastoma patients based on the expression of a set of real-time RT-PCR markers in tumor-initiating cells.
Tongue Neoplasms
Kinesin family member 20B regulates tongue cancer progression by promoting cell proliferation.
Tooth Diseases
Mutation in KIF5A c.610C>T Causing Hereditary Spastic Paraplegia with Axonal Sensorimotor Neuropathy.
Tooth Diseases
The kinesin superfamily protein Rab6KIFL is not involved in the pathophysiology of Charcot-Marie-Tooth disease type 4C.
Triple Negative Breast Neoplasms
ARF6-JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion.
Triple Negative Breast Neoplasms
Chemogenetic evaluation of the mitotic kinesin CENP-E reveals a critical role in triple-negative breast cancer.
Triple Negative Breast Neoplasms
Chromosomally unstable tumor cells specifically require KIF18A for proliferation.
Triple Negative Breast Neoplasms
Identification by Comprehensive Bioinformatics Analysis of KIF15 as a Candidate Risk Gene for Triple-Negative Breast Cancer.
Triple Negative Breast Neoplasms
KIF11 is required for proliferation and self-renewal of docetaxel resistant triple negative breast cancer cells.
Triple Negative Breast Neoplasms
KIFC1 is a novel potential therapeutic target for breast cancer.
Triple Negative Breast Neoplasms
Knockdown of Kinase Family 15 Inhibits Cancer Cell Proliferation In vitro and its Clinical Relevance in Triple-Negative Breast Cancer.
Triple Negative Breast Neoplasms
Multi-institutional study of nuclear KIFC1 as a biomarker of poor prognosis in African American women with triple-negative breast cancer.
Triple Negative Breast Neoplasms
Suppression of KIF3A inhibits triple negative breast cancer growth and metastasis by repressing Rb-E2F signaling and epithelial-mesenchymal transition.
Trypanosomiasis
Trypanosoma musculi Infection in Mice Critically Relies on Mannose Receptor-Mediated Arginase Induction by a TbKHC1 Kinesin H Chain Homolog.
Tuberculosis
Association analysis of susceptibility candidate region on chromosome 5q31 for tuberculosis.
Tuberculosis
Immunogenicity of candidate chimeric DNA vaccine against tuberculosis and leishmaniasis.
Tuberculosis
Mapping epigenetic changes to the host cell genome induced by Burkholderia pseudomallei reveals pathogen-specific and pathogen-generic signatures of infection.
Tuberous Sclerosis
Effect of Sishen Pill on Memory T Cells From Experimental Colitis Induced by Dextran Sulfate Sodium.
Ureteral Obstruction
[Expression of kinesin KIF3A in the kidney of mice with unilateral ureteral obstruction].
Urinary Bladder Neoplasms
GSG2 (Haspin) promotes development and progression of bladder cancer through targeting KIF15 (Kinase-12).
Urinary Bladder Neoplasms
KIF15 promotes bladder cancer proliferation via the MEK-ERK signaling pathway.
Urinary Bladder Neoplasms
KIF20A Affects the Prognosis of Bladder Cancer by Promoting the Proliferation and Metastasis of Bladder Cancer Cells.
Urinary Bladder Neoplasms
KIF4A promotes the development of bladder cancer by transcriptionally activating the expression of CDCA3.
Urinary Bladder Neoplasms
KIF5A Promotes Bladder Cancer Proliferation In Vitro and In Vivo.
Urinary Bladder Neoplasms
Kinesin family member 23 (KIF23) contributes to the progression of bladder cancer cells in vitro and in vivo.
Urinary Bladder Neoplasms
Kinesin family member 3A stimulates cell proliferation, migration, and invasion of bladder cancer cells in vitro and in vivo.
Urinary Bladder Neoplasms
Kinesin family member C1 accelerates bladder cancer cell proliferation and induces epithelial-mesenchymal transition via Akt/GSK3? signaling.
Urinary Bladder Neoplasms
Positive expression of KIF20A indicates poor prognosis of glioma patients.
Urinary Bladder Neoplasms
Screening and identification of hub genes in bladder cancer by bioinformatics analysis and KIF11 is a potential prognostic biomarker.
Urinary Bladder Neoplasms
TPX2-p53-GLIPR1 regulatory circuitry in cell proliferation, invasion, and tumor growth of bladder cancer.
Uterine Cervical Neoplasms
Clinical significance of kinesin family member 2A as a facilitating biomarker of disease surveillance and prognostication in cervical cancer patients.
Uterine Cervical Neoplasms
High Expression of KIF20A Is Associated with Poor Overall Survival and Tumor Progression in Early-Stage Cervical Squamous Cell Carcinoma.
Uterine Cervical Neoplasms
Integrated analysis reveals down-regulation of SPARCL1 is correlated with cervical cancer development and progression.
Uterine Cervical Neoplasms
Long Intervening Noncoding 00467 RNA Contributes to Tumorigenesis by Acting as a Competing Endogenous RNA against miR-107 in Cervical Cancer Cells.
Uterine Cervical Neoplasms
SETD3 reduces KLC4 expression to improve the sensitization of cervical cancer cell to radiotherapy.
Vaccinia
A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome.
Vaccinia
Interaction of poxvirus intracellular mature virion proteins with the TPR domain of kinesin light chain in live infected cells revealed by two photon-induced Fluorescence Resonance Energy Transfer Fluorescence Lifetime Imaging Microscopy.
Vaccinia
Loss of cytoskeletal transport during egress critically attenuates ectromelia virus infection in vivo.
Vaccinia
Phototracking Vaccinia Virus Transport Reveals Dynamics of Cytoplasmic Dispersal and a Requirement for A36R and F12L for Exit from the Site of Wrapping.
Vaccinia
The release of vaccinia virus from infected cells requires RhoA-mDia modulation of cortical actin.
Vaccinia
Vaccinia protein F12 has structural similarity to kinesin light chain and contains a motor binding motif required for virion export.
Vaccinia
Vaccinia virus A36R membrane protein provides a direct link between intracellular enveloped virions and the microtubule motor kinesin.
Vaccinia
Vaccinia virus egress mediated by virus protein A36 is reliant on the F12 protein.
Vaccinia
Vaccinia virus protein complex f12/e2 interacts with Kinesin light chain isoform 2 to engage the Kinesin-1 motor complex.
Vaccinia
Vaccinia virus proteins A36 and F12/E2 show strong preferences for different kinesin light chain isoforms.
Varicocele
Protein Fingerprinting of Seminal Plasma Reveals Dysregulation of Exosome-Associated Proteins in Infertile Men with Unilateral Varicocele.
Vascular Diseases
A mouse model for Kinesin Family Member 11 (Kif11)-associated familial exudative vitreoretinopathy.
Vesicular Stomatitis
A new role of anterograde motor Kif5b in facilitating large clathrin-coated vesicle mediated endocytosis via regulating clathrin uncoating.
Vesicular Stomatitis
Kinesin is the motor for microtubule-mediated Golgi-to-ER membrane traffic.
Virus Diseases
Pseudorabies Virus Infection Accelerates Degradation of the Kinesin-3 Motor KIF1A.
von Hippel-Lindau Disease
High kinesin family member 11 expression predicts poor prognosis in patients with clear cell renal cell carcinoma.
Wilms Tumor
Immune responses against tumour-associated antigen-derived cytotoxic T lymphocyte epitopes in cholangiocarcinoma patients.
Wilms Tumor
KIF11 as a potential cancer prognostic marker promotes tumorigenesis in children with Wilms tumor.
Wiskott-Aldrich Syndrome
ARF6-JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion.
Yellow Fever
Evolutionary analysis of the kinesin light chain genes in the yellow fever mosquito Aedes aegypti: gene duplication as a source for novel early zygotic genes.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.000047
ATP
pH 6.8, 25°C, tubuline-stimulated recombinant Kif2C functional domain mutant DSK
0.000058
ATP
pH 6.8, 25°C, tubuline-stimulated recombinant Kif2C functional domain mutant DVK
0.00008
ATP
pH 6.8, 25°C, tubulin-stimulated recombinant Kif2C functional domain wild-type
0.00018
ATP
pH 6.8, 25°C, tubulin-stimulated recombinant Kif2C functional domain mutant L2
0.0006
ATP
pH 6.8, 25°C, microtubule-stimulated recombinant Kif2C functional domain mutant DSK
0.00062
ATP
pH 6.8, 25°C, tubulin-vinblastine-stimulated recombinant Kif2C functional domain mutant L2
0.00105
ATP
pH 6.8, 25°C, microtubule-stimulated recombinant Kif2C functional domain mutant DVK
0.0013
ATP
pH 6.8, 25°C, microtubule-stimulated recombinant Kif2C functional domain mutant L2
0.00388
ATP
pH 6.8, 25°C, tubulin-vinblastine-stimulated recombinant Kif2C functional domain wild-type
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.069
ATP
pH 6.8, 25°C, tubulin-vinblastine-stimulated recombinant Kif2C functional domain mutant L2
0.079
ATP
pH 6.8, 25°C, tubuline-stimulated recombinant Kif2C functional domain mutant DSK
0.1
ATP
pH 6.8, 25°C, tubuline-stimulated recombinant Kif2C functional domain mutant DVK
0.117
ATP
pH 6.8, 25°C, tubulin-stimulated recombinant Kif2C functional domain mutant L2
0.152
ATP
pH 6.8, 25°C, tubulin-stimulated recombinant Kif2C functional domain wild-type
0.18
ATP
pH 6.8, 25°C, microtubule-stimulated recombinant Kif2C functional domain mutant DSK
0.21
ATP
pH 6.8, 25°C, microtubule-stimulated recombinant Kif2C functional domain mutant L2
0.62
ATP
pH 6.8, 25°C, tubulin-vinblastine-stimulated recombinant Kif2C functional domain wild-type
0.97
ATP
pH 6.8, 25°C, microtubule-stimulated recombinant Kif2C functional domain mutant DVK
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
the interaction of the kinesin-13 Kif2C KVD motif with tubulin is essential. The interaction of the KVD motif quantitatively determines the activities of Kif2C
additional information
kinesin-13s have a clearly longer loop 2 that folds as a beta-hairpin with a conserved KVD motif at its tip. This KVD motif is necessary for microtubule depolymerization by kinesin-13s. Structural modeling of the Kif2C motor domain in its ATP state in complex with tubulin, overview. The beta-hairpin structure of loop 2 is conserved but shortened. In the mutant, as in the wild type protein, the hairpin that displays the KVD motif interacts similarly with the neck helix, but the KVD motif contacts neither the rest of the motor domain nor the neck helix
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). KIF2C_HUMAN
725
0
81313
Swiss-Prot
other Location (Reliability: 2)
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
purified recombinant minimal functional domain Kif2C-(sN+M)-sL2 in complex with ADP, by vapor diffusion using a crystallization buffer consisting of 0.1 M Tris-HCl, pH 8.0, 1.5 M ammonium sulfate, and 10% ethylene glycol, at 20°C, X-ray diffraction structure determination and analysis at 2.6 A resolution, molecular replacement using HsKif2C motor domain-ADP, PDB ID 2HEH, as a starting model
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
construction of L2, DVK, and DSK loop2 mutants of the functional domain of Kif2C, the microtubule depolymerization activity of the DVK mutant is remarkably decreased compared to the wild-type, while the DSK mutant does not show microtubule depolymerization activity even at high concentrations
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant expression of the wild-type and mutant minimal functional domain of Kif2C, a fragment comprising the proximal part of the neck region and the motor domain
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wang, W.; Shen, T.; Guerois, R.; Zhang, F.; Kuerban, H.; Lv, Y.; Gigant, B.; Knossow, M.; Wang, C.
New insights into the coupling between microtubule depolymerization and ATP hydrolysis by kinesin-13 protein Kif2C
J. Biol. Chem.
290
18721-18731
2015
Homo sapiens (Q99661)
brenda
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