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Information on EC 5.6.1.2 - dynein ATPase
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5.6.1.2 dynein ATPaseIUBMB Comments
A multisubunit protein complex associated with microtubules. Hydrolysis of ATP provides energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome towards the microtubule's minus end. It also functions in the movement of eukaryotic flagella and cilia. It consists of two heavy chains (about 500 kDa), three-four intermediate chains (about 70 kDa) and four light chains (about 50 kDa).
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Word Map
- 5.6.1.2
- kinesins
- cilia
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cargo
- spindle
- myosin
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mitotic
- actin
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retrograde
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dynactin
- sperm
- drosophila
- cytoskeleton
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beat
- chlamydomonas
- centrosome
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microtubule-based
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doublet
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minus
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slide
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sliding
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anterograde
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microtubule-associated
- dyskinesia
- spoke
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microtubule-dependent
- urchin
- kinetochore
- flagellum
- tetrahymena
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microtubule-binding
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mechanochemical
- plus-ends
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immotile
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anaphase
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intraflagellar
- microtubular
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left-right
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prometaphase
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ciliogenesis
- aster
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force-generating
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actin-based
- bronchiectasis
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mucociliary
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kinesin-like
- sinusitis
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mtocs
- medicine
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aggresome
- ciliopathies
- diagnostics
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protofilaments
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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a dynein associated with a microtubule at position n
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a dynein associated with a microtubule at position n-1 (toward the minus end)
Synonyms
dynein, motor protein, microtubule motor, dynein motor, axonemal dynein, tctex-1, outer arm dynein, dynein-2, dynein motor complex, dynein-atpase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphonic ester bond
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SYSTEMATIC NAME
IUBMB Comments
ATP phosphohydrolase (tubulin-translocating)
A multisubunit protein complex associated with microtubules. Hydrolysis of ATP provides energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome towards the microtubule's minus end. It also functions in the movement of eukaryotic flagella and cilia. It consists of two heavy chains (about 500 kDa), three-four intermediate chains (about 70 kDa) and four light chains (about 50 kDa).
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CAS REGISTRY NUMBER
COMMENTARY
9000-83-3
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + H2O + a dynein associated with a microtubule at position n
ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
ATP + H2O + a dynein associated with a microtubule at position n
ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
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ATP + H2O + a dynein associated with a microtubule at position n
ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
cytoplasmic dynein is an AAA+ motor responsible for intracellular cargo transport and force generation along microtubules
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ATP + H2O + a dynein associated with a microtubule at position n
ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
dynein contains multiple ATPase subunits, with AAA1 serving as the primary catalytic site. ATPase activity at AAA3 is also essential for robust motility. The AAA3 domain of cytoplasmic dynein acts as a switch to facilitate microtubule release
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ATP + H2O + a dynein associated with a microtubule at position n
ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
dynein is responsible for most microtubule minus-end-directed motility. Dynein contains four AAA+ ATPases per motor domain (AAA1-4). The main site of ATP hydrolysis is AAA1. ATP binding to AAA1 induces microtubule release only if AAA3 is in the posthydrolysis state
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + H2O + a dynein associated with a microtubule at position n
ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
ATP + H2O + a dynein associated with a microtubule at position n
ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
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-
-
?
ATP + H2O + a dynein associated with a microtubule at position n
ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
cytoplasmic dynein is an AAA+ motor responsible for intracellular cargo transport and force generation along microtubules
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
ODA16 aids axonemal outer row dynein assembly through an interaction with the intraflagellar transport machinery.
Acquired Immunodeficiency Syndrome
Protein structural transitions and their functional role.
Adenocarcinoma
Association between aberrant dynein cytoplasmic 1 light intermediate chain 1 expression levels, mucins and chemosensitivity in colorectal cancer.
Adenocarcinoma of Lung
High EGFR_1 Inside-Out Activated Inflammation-Induced Motility through SLC2A1-CCNB2-HMMR-KIF11-NUSAP1-PRC1-UBE2C.
Adenocarcinoma of Lung
Kinesin KIF4A is associated with chemotherapeutic drug resistance by regulating intracellular trafficking of lung resistance-related protein.
Adenocarcinoma of Lung
The motor protein KIF14 inhibits tumor growth and cancer metastasis in lung adenocarcinoma.
Adenomatous Polyposis Coli
A role for regulated binding of p150(Glued) to microtubule plus ends in organelle transport.
Adenomatous Polyposis Coli
Genetic enhancement of the Lis1+/- phenotype by a heterozygous mutation in the adenomatous polyposis coli gene.
Adenomatous Polyposis Coli
Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein.
African Swine Fever
African swine fever virus protein p54 interacts with the microtubular motor complex through direct binding to light-chain dynein.
African Swine Fever
Particle tracking analysis for the intracellular trafficking of nanoparticles modified with African swine fever virus protein p54-derived peptide.
African Swine Fever
Small peptide inhibitors disrupt a high-affinity interaction between cytoplasmic dynein and a viral cargo protein.
Alzheimer Disease
Cytoplasmic dynein: a key player in neurodegenerative and neurodevelopmental diseases.
Alzheimer Disease
Dynein-dynactin complex subunits are differentially localized in brain and spinal cord, with selective involvement in pathological features of neurodegenerative disease.
Alzheimer Disease
Levels of kinesin light chain and dynein intermediate chain are reduced in the frontal cortex in Alzheimer's disease: implications for axoplasmic transport.
Alzheimer Disease
LMD proteomics provides evidence for hippocampus field-specific motor protein abundance changes with relevance to Alzheimer's disease.
Alzheimer Disease
Presenilin influences Glycogen Synthase Kinase-3beta (GSK-3?) for kinesin-1 and dynein function during axonal transport.
Alzheimer Disease
The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites.
Amyotrophic Lateral Sclerosis
Alteration of Motor Protein Expression Involved in Bidirectional Transport in Peripheral Blood Mononuclear Cells of Patients with Amyotrophic Lateral Sclerosis.
Amyotrophic Lateral Sclerosis
Altered Dynein Axonemal Assembly Factor 1 Expression in C-Boutons in Bulbar and Spinal Cord Motor-Neurons in Sporadic Amyotrophic Lateral Sclerosis.
Amyotrophic Lateral Sclerosis
Cytoplasmic dynein: a key player in neurodegenerative and neurodevelopmental diseases.
Amyotrophic Lateral Sclerosis
Dynactin Deficiency in the CNS of Humans with Sporadic ALS and Mice with Genetically Determined Motor Neuron Degeneration.
Amyotrophic Lateral Sclerosis
Dynein disruption perturbs post-synaptic components and contributes to impaired MuSK clustering at the NMJ: implication in ALS.
Amyotrophic Lateral Sclerosis
Interaction between familial amyotrophic lateral sclerosis (ALS)-linked SOD1 mutants and the dynein complex.
Amyotrophic Lateral Sclerosis
Mutant glycyl-tRNA synthetase (Gars) ameliorates SOD1(G93A) motor neuron degeneration phenotype but has little affect on Loa dynein heavy chain mutant mice.
Anthrax
Kif1C, a kinesin-like motor protein, mediates mouse macrophage resistance to anthrax lethal factor.
Aortic Aneurysm, Thoracic
Exome sequencing in seven families and gene-based association studies indicate genetic heterogeneity and suggest possible candidates for fibromuscular dysplasia.
Aortic Diseases
Genetic approaches to identify pathological limitations in aortic smooth muscle contraction.
Asthenozoospermia
CCDC9 is identified as a novel candidate gene of severe asthenozoospermia.
Asthenozoospermia
Disruption of an inner arm dynein heavy chain gene results in asthenozoospermia and reduced ciliary beat frequency.
Asthenozoospermia
Disruption of the murine dynein light chain gene Tcte3-3 results in asthenozoospermia.
Asthenozoospermia
Further studies on knockout mice lacking a functional dynein heavy chain (MDHC7). 2. A developmental explanation for the asthenozoospermia.
Asthenozoospermia
Loss of Calmodulin- and Radial-Spoke-Associated Complex Protein CFAP251 Leads to Immotile Spermatozoa Lacking Mitochondria and Infertility in Men.
Asthenozoospermia
Motor apparatus in human spermatozoa that lack central pair microtubules.
Asthenozoospermia
Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.
Asthenozoospermia
Mutations in dynein genes in patients affected by isolated non-syndromic asthenozoospermia.
Asthenozoospermia
Two mutations in the axonemal dynein heavy chain gene 5 in a Chinese asthenozoospermia patient: A case report.
Asthenozoospermia
Whole-exome sequencing of familial cases of multiple morphological abnormalities of the sperm flagella (MMAF) reveals new DNAH1 mutations.
Asthma
Atypical bronchial cilia in children with recurrent respiratory tract infections. A comparative ultrastructural study.
Bardet-Biedl Syndrome
Protein profile of Dabry's sturgeon (Acipenser dabryanus) spermatozoa and relationship to sperm quality.
Blast Crisis
Regulation and Targeting of Eg5, a Mitotic Motor Protein in Blast Crisis CML: Overcoming Imatinib Resistance.
Bone Resorption
Tctex-1, a Novel Interaction Partner of Rab3D, Is Required for Osteoclastic Bone Resorption.
Brain Injuries, Traumatic
Immunolocalization of dynein, dynactin, and kinesin in the cerebral tissue as a possible supplemental diagnostic tool for traumatic brain injury in postmortem examination.
Brain Ischemia
Induction of protein inhibitor of neuronal nitric oxide synthase/cytoplasmic dynein light chain following cerebral ischemia.
Brain Ischemia
Temporal profiles of the subcellular localization of Bim, a BH3-only protein, during middle cerebral artery occlusion in mice.
Brain Ischemia
[Effect of hypothermia on activities of tubule motor protein and constructure protein after cerebral ischemia in gerbils].
Breast Neoplasms
High EGFR_1 Inside-Out Activated Inflammation-Induced Motility through SLC2A1-CCNB2-HMMR-KIF11-NUSAP1-PRC1-UBE2C.
Breast Neoplasms
Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development.
Breast Neoplasms
RNA interference-mediated silencing of mitotic kinesin KIF14 disrupts cell cycle progression and induces cytokinesis failure.
Breast Neoplasms
Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF-? signaling.
Bronchiectasis
Atypical bronchial cilia in children with recurrent respiratory tract infections. A comparative ultrastructural study.
Bronchiectasis
Discordant organ laterality in monozygotic twins with primary ciliary dyskinesia.
Bronchiectasis
Inherited factors in diffuse bronchiectasis in the adult: a prospective study.
Bronchiectasis
Mutations of DNAH11 in patients with primary ciliary dyskinesia with normal ciliary ultrastructure.
Bronchiectasis
Ultrastructural abnormalities of bronchial cilia in children with recurrent airway infections and bronchiectasis.
Bronchitis
The immotile cilia syndrome: phase contrast light microscopy, scanning and transmission electron microscopy.
Bronchitis
[Results of nasal brushing in the study of ciliary conformation and function in chronic bronchopneumopathies in childhood]
Bronchopneumonia
Histologic and Ultrastructural Findings in Dogs With Chronic Respiratory Disease Suspected of Ciliary Dyskinesia.
Bulbo-Spinal Atrophy, X-Linked
Lysosomal proliferation and distal degeneration in motor neurons expressing the G59S mutation in the p150Glued subunit of dynactin.
Bulbo-Spinal Atrophy, X-Linked
Mutation analysis of genes within the dynactin complex in a cohort of hereditary peripheral neuropathies.
Carcinogenesis
Corrigendum: Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5.
Carcinogenesis
DYNC1I1 Promotes the Proliferation and Migration of Gastric Cancer by Up-Regulating IL-6 Expression.
Carcinogenesis
Ectopic expression of the microtubule-dependent motor protein Eg5 promotes pancreatic tumourigenesis.
Carcinogenesis
Inhibition of prostate tumor growth by overexpression of NudC, a microtubule motor-associated protein.
Carcinogenesis
Parkin regulates Eg5 expression by Hsp70 ubiquitination-dependent inactivation of c-Jun NH2-terminal kinase.
Carcinogenesis
Ubiquitin ligase RNF20/40 facilitates spindle assembly and promotes breast carcinogenesis through stabilizing motor protein Eg5.
Carcinoma
Kinesin motor protein KIFC1 is a target protein of miR-338-3p and associated with poor prognosis and progression of renal cell carcinoma.
Carcinoma
Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer.
Carcinoma
Overexpression of the dynein light chain km23-1 in human ovarian carcinoma cells inhibits tumor formation in vivo and causes mitotic delay at prometaphase/metaphase.
Carcinoma
The kinesin motor protein KIF4A as a potential therapeutic target in renal cell carcinoma.
Carcinoma, Hepatocellular
Association between aberrant dynein cytoplasmic 1 light intermediate chain 1 expression levels, mucins and chemosensitivity in colorectal cancer.
Carcinoma, Hepatocellular
Identification of two novel human dynein light chain genes, DNLC2A and DNLC2B, and their expression changes in hepatocellular carcinoma tissues from 68 Chinese patients.
Carcinoma, Hepatocellular
Lidocaine has antitumor effect on hepatocellular carcinoma via the circ_DYNC1H1/miR-520a-3p/USP14 axis.
Carcinoma, Ovarian Epithelial
Crystal structure of human dynein light chain Dnlc2A: Structural insights into the interaction with IC74.
Carcinoma, Renal Cell
Kinesin motor protein KIFC1 is a target protein of miR-338-3p and associated with poor prognosis and progression of renal cell carcinoma.
Carcinoma, Renal Cell
The kinesin motor protein KIF4A as a potential therapeutic target in renal cell carcinoma.
Cardiomyopathies
Deciphering the super relaxed state of human ?-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers.
Cardiomyopathy, Hypertrophic
Myosin VI Is a Mediator of the p53-Dependent Cell Survival Pathway.
Cardiomyopathy, Hypertrophic
The molecular phenotype of human cardiac myosin associated with hypertrophic obstructive cardiomyopathy.
Cardiomyopathy, Hypertrophic, Familial
Altered myocyte contractility and calcium homeostasis in alpha-myosin heavy chain point mutations linked to familial dilated cardiomyopathy.
Cardiomyopathy, Hypertrophic, Familial
In vivo analysis of an essential myosin light chain mutation linked to familial hypertrophic cardiomyopathy.
Charcot-Marie-Tooth Disease
Analysis of dynein intermediate chains, light intermediate chains and light chains in a cohort of hereditary peripheral neuropathies.
Charcot-Marie-Tooth Disease
Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins.
Charcot-Marie-Tooth Disease
Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta.
Charcot-Marie-Tooth Disease
Cytoplasmic dynein: a key player in neurodegenerative and neurodevelopmental diseases.
Charcot-Marie-Tooth Disease
DYNC1H1 mutation alters transport kinetics and ERK1/2-cFos signalling in a mouse model of distal spinal muscular atrophy.
Charcot-Marie-Tooth Disease
From the cell membrane to the nucleus: unearthing transport mechanisms for Dynein.
Charcot-Marie-Tooth Disease
iMotor-CNN: Identifying molecular functions of cytoskeleton motor proteins using 2D convolutional neural network via Chou's 5-step rule.
Cholangitis, Sclerosing
Identification of novel loci for pediatric cholestatic liver disease defined by KIF12, PPM1F, USP53, LSR, and WDR83OS pathogenic variants.
Cholestasis, Intrahepatic
A molecular mechanism underlying genotype-specific intrahepatic cholestasis resulting from MYO5B mutations.
Ciliary Motility Disorders
A New Tool Improves Diagnostic Test Performance for Transmission EM Evaluation of Axonemal Dynein Arms.
Ciliary Motility Disorders
A NIMA-Related Kinase Suppresses the Flagellar Instability Associated with the Loss of Multiple Axonemal Structures.
Ciliary Motility Disorders
Abnormal central complex is a marker of severity in the presence of partial ciliary defect.
Ciliary Motility Disorders
Axonemal beta heavy chain dynein DNAH9: cDNA sequence, genomic structure, and investigation of its role in primary ciliary dyskinesia.
Ciliary Motility Disorders
Axonemal dynein intermediate-chain gene (DNAI1) mutations result in situs inversus and primary ciliary dyskinesia (Kartagener syndrome).
Ciliary Motility Disorders
Axonemal Localization of the Dynein Component DNAH5 Is Not Altered in Secondary Ciliary Dyskinesia.
Ciliary Motility Disorders
Bi-allelic mutations in DNAH7 cause asthenozoospermia by impairing the integrality of axoneme structure.
Ciliary Motility Disorders
Biochemical and molecular characterization of diseases linked to motor proteins.
Ciliary Motility Disorders
CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms.
Ciliary Motility Disorders
CCDC151 mutations cause primary ciliary dyskinesia by disruption of the outer dynein arm docking complex formation.
Ciliary Motility Disorders
CFAP300: Mutations in Slavic Primary Ciliary Dyskinesia Patients and a Role in Ciliary Dynein Arms Trafficking.
Ciliary Motility Disorders
Characterization of the medaka (Oryzias latipes) primary ciliary dyskinesia mutant, jaodori: Redundant and distinct roles of dynein axonemal intermediate chain 2 (dnai2) in motile cilia.
Ciliary Motility Disorders
Ciliary beating recovery in deficient human airway epithelial cells after lentivirus ex vivo gene therapy.
Ciliary Motility Disorders
Ciliary function analysis for the diagnosis of primary ciliary dyskinesia: advantages of ciliogenesis in culture.
Ciliary Motility Disorders
Ciliary function and motor protein composition of human fallopian tubes.
Ciliary Motility Disorders
Combined exome and whole-genome sequencing identifies mutations in ARMC4 as a cause of primary ciliary dyskinesia with defects in the outer dynein arm.
Ciliary Motility Disorders
Computer-assisted analysis helps detect inner dynein arm abnormalities.
Ciliary Motility Disorders
Deletions and point mutations of LRRC50 cause primary ciliary dyskinesia due to dynein arm defects.
Ciliary Motility Disorders
Delineation of CCDC39/CCDC40 mutation spectrum and associated phenotypes in primary ciliary dyskinesia.
Ciliary Motility Disorders
DNAAF1 links heart laterality with the AAA+ ATPase RUVBL1 and ciliary intraflagellar transport.
Ciliary Motility Disorders
DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease.
Ciliary Motility Disorders
DNAH5 mutations are a common cause of primary ciliary dyskinesia with outer dynein arm defects.
Ciliary Motility Disorders
DNAI2 mutations cause primary ciliary dyskinesia with defects in the outer dynein arm.
Ciliary Motility Disorders
Genetic heterogeneity of dynein-deficiency in cilia from patients with respiratory disease.
Ciliary Motility Disorders
Germline mutations in an intermediate chain dynein cause primary ciliary dyskinesia.
Ciliary Motility Disorders
Homozygosity mapping of a gene locus for primary ciliary dyskinesia on chromosome 5p and identification of the heavy dynein chain DNAH5 as a candidate gene.
Ciliary Motility Disorders
Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients.
Ciliary Motility Disorders
Identification of dynein heavy chain 7 as an inner arm component of human cilia that is synthesized but not assembled in a case of primary ciliary dyskinesia.
Ciliary Motility Disorders
Identification of predicted human outer dynein arm genes: candidates for primary ciliary dyskinesia genes.
Ciliary Motility Disorders
Identification, tissue specific expression, and chromosomal localisation of several human dynein heavy chain genes.
Ciliary Motility Disorders
Inherited factors in diffuse bronchiectasis in the adult: a prospective study.
Ciliary Motility Disorders
Inner dynein arm defects causing Primary Ciliary Dyskinesia: Repeat testing required.
Ciliary Motility Disorders
Long-term follow-up of the clinical relevance of short outer dynein arms in human nasal cilia.
Ciliary Motility Disorders
Loss of function of axonemal dynein Mdnah5 causes primary ciliary dyskinesia and hydrocephalus.
Ciliary Motility Disorders
Loss-of-function mutations in a human gene related to Chlamydomonas reinhardtii dynein IC78 result in primary ciliary dyskinesia.
Ciliary Motility Disorders
Loss-of-function mutations in CCDC114 cause primary ciliary dyskinesia.
Ciliary Motility Disorders
Loss-of-function mutations in LRRC6, a gene essential for proper axonemal assembly of inner and outer dynein arms, cause primary ciliary dyskinesia.
Ciliary Motility Disorders
Loss-of-function mutations in the human ortholog of Chlamydomonas reinhardtii ODA7 disrupt dynein arm assembly and cause primary ciliary dyskinesia.
Ciliary Motility Disorders
LRRC6 Mutation Causes Primary Ciliary Dyskinesia with Dynein Arm Defects.
Ciliary Motility Disorders
Microtubular protofilaments and subunits of the outer dynein arm in cilia from dogs with primary ciliary dyskinesia.
Ciliary Motility Disorders
Motor domain-based motility system and motile properties of alpha heavy chain in Tetrahymena outer arm dynein.
Ciliary Motility Disorders
Mouse dynein axonemal intermediate chain 2: cloning and expression.
Ciliary Motility Disorders
Mutation of CFAP57, a protein required for the asymmetric targeting of a subset of inner dynein arms in Chlamydomonas, causes primary ciliary dyskinesia.
Ciliary Motility Disorders
Mutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia.
Ciliary Motility Disorders
Mutations in C11orf70 Cause Primary Ciliary Dyskinesia with Randomization of Left/Right Body Asymmetry Due to Defects of Outer and Inner Dynein Arms.
Ciliary Motility Disorders
Mutations in CCDC39 and CCDC40 are the major cause of primary ciliary dyskinesia with axonemal disorganization and absent inner dynein arms.
Ciliary Motility Disorders
Mutations in Outer Dynein Arm Heavy Chain DNAH9 Cause Motile Cilia Defects and Situs Inversus.
Ciliary Motility Disorders
Mutations in PIH1D3 Cause X-Linked Primary Ciliary Dyskinesia with Outer and Inner Dynein Arm Defects.
Ciliary Motility Disorders
Mutations in SPAG1 Cause Primary Ciliary Dyskinesia Associated with Defective Outer and Inner Dynein Arms.
Ciliary Motility Disorders
Mutations in the DNAH11 (axonemal heavy chain dynein type 11) gene cause one form of situs inversus totalis and most likely primary ciliary dyskinesia.
Ciliary Motility Disorders
Mutations in ZMYND10, a Gene Essential for Proper Axonemal Assembly of Inner and Outer Dynein Arms in Humans and Flies, Cause Primary Ciliary Dyskinesia.
Ciliary Motility Disorders
Nine Japanese patients with immotile-dyskinetic cilia syndrome: an ultrastructural study using tannic acid-containing fixation.
Ciliary Motility Disorders
Normal ciliary ultrastructure in children with Kartagener's syndrome.
Ciliary Motility Disorders
Novel dynein axonemal assembly factor 1 mutations identified using whole?exome sequencing in patients with primary ciliary dyskinesia.
Ciliary Motility Disorders
Population specificity of the DNAI1 gene mutation spectrum in primary ciliary dyskinesia (PCD).
Ciliary Motility Disorders
Primary ciliary dyskinesia: diagnosis in children with inconclusive ultrastructural evaluation.
Ciliary Motility Disorders
Repetitive ejaculation before intracytoplasmic sperm injection in patients with absolute immotile spermatozoa.
Ciliary Motility Disorders
Respiratory distress in a newborn with primary ciliary dyskinesia, situs inversus and Turner syndrome.
Ciliary Motility Disorders
Splice-site mutations in the axonemal outer dynein arm docking complex gene CCDC114 cause primary ciliary dyskinesia.
Ciliary Motility Disorders
Successful intracytoplasmic sperm injection with spermatozoa from a patient with dysplasia of the fibrous sheath and chronic respiratory disease.
Ciliary Motility Disorders
Teratozoospermia: spotlight on the main genetic actors in the human.
Ciliary Motility Disorders
Testing ciliary activity in patients with chronic and recurrent infections of the upper airways: experiences in 68 cases.
Ciliary Motility Disorders
The human dynein intermediate chain 2 gene (DNAI2): cloning, mapping, expression pattern, and evaluation as a candidate for primary ciliary dyskinesia.
Ciliary Motility Disorders
The immotile cilia syndrome: phase contrast light microscopy, scanning and transmission electron microscopy.
Ciliary Motility Disorders
The Oligomeric Outer Dynein Arm Assembly Factor CCDC103 is Tightly Integrated within the Ciliary Axoneme and Exhibits Periodic Binding to Microtubules.
Ciliary Motility Disorders
TTC12 Loss-of-Function Mutations Cause Primary Ciliary Dyskinesia and Unveil Distinct Dynein Assembly Mechanisms in Motile Cilia Versus Flagella.
Ciliary Motility Disorders
TTC25 Deficiency Results in Defects of the Outer Dynein Arm Docking Machinery and Primary Ciliary Dyskinesia with Left-Right Body Asymmetry Randomization.
Ciliary Motility Disorders
Two novel mutations in the DNAH11 gene in primary ciliary dyskinesia (CILD7) with considerable variety in the clinical and beating cilia phenotype.
Ciliary Motility Disorders
Ultrastructural abnormalities of cilia in the human respiratory tract.
Ciliary Motility Disorders
Ultrastructural expression of primary ciliary dyskinesia after ciliogenesis in culture.
Ciliary Motility Disorders
Utilization of digital image processing to study dynein arms (ATPase) in normal and immotile cilia.
Ciliary Motility Disorders
Wampa is a dynein subunit required for axonemal assembly and male fertility in Drosophila.
Ciliary Motility Disorders
X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3.
Ciliary Motility Disorders
ZMYND10 functions in a chaperone relay during axonemal dynein assembly.
Ciliary Motility Disorders
[Genetically Determined and Functional Human Sperm Motility Decrease].
Ciliary Motility Disorders
[The absence of the internal arms of dynein as a cause of the immotile cilia syndrome]
Ciliopathies
ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis.
Ciliopathies
CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module.
Ciliopathies
Defects in the IFT-B component IFT172 cause Jeune and Mainzer-Saldino syndromes in humans.
Ciliopathies
Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function.
Ciliopathies
Mutations in ZMYND10, a Gene Essential for Proper Axonemal Assembly of Inner and Outer Dynein Arms in Humans and Flies, Cause Primary Ciliary Dyskinesia.
Classical Lissencephalies and Subcortical Band Heterotopias
A mosaic genetic screen for genes necessary for Drosophila mushroom body neuronal morphogenesis.
Classical Lissencephalies and Subcortical Band Heterotopias
Dynein binds and stimulates axonal motility of the endosome adaptor and NEEP21 family member, calcyon.
Classical Lissencephalies and Subcortical Band Heterotopias
Human Asunder promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry.
Classical Lissencephalies and Subcortical Band Heterotopias
Identification of a novel dynein binding domain in nudel essential for spindle pole organization in Xenopus egg extract.
Classical Lissencephalies and Subcortical Band Heterotopias
N-Acetyl-D-Glucosamine Kinase Interacts with NudC and Lis1 in Dynein Motor Complex and Promotes Cell Migration.
Classical Lissencephalies and Subcortical Band Heterotopias
NuMA1 promotes axon initial segment assembly through inhibition of endocytosis.
Classical Lissencephalies and Subcortical Band Heterotopias
Regulators of the cytoplasmic dynein motor.
Classical Lissencephalies and Subcortical Band Heterotopias
The L279P mutation of nuclear distribution gene C (NudC) influences its chaperone activity and lissencephaly protein 1 (LIS1) stability.
Classical Lissencephalies and Subcortical Band Heterotopias
The lissencephaly protein Lis1 is present in motile mammalian cilia and requires outer arm dynein for targeting to Chlamydomonas flagella.
Classical Lissencephalies and Subcortical Band Heterotopias
The phospholipase complex PAFAH Ib regulates the functional organization of the Golgi complex.
Classical Lissencephalies and Subcortical Band Heterotopias
The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly.
Colonic Neoplasms
Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus.
Colorectal Neoplasms
Association between aberrant dynein cytoplasmic 1 light intermediate chain 1 expression levels, mucins and chemosensitivity in colorectal cancer.
Confusion
Ciliary ultrastructure and nasal mucociliary clearance in chronic and allergic rhinitis.
Confusion
Electron microscopy assessment of the recovery of sinus mucosa after sinus surgery.
Cystic Fibrosis
Atypical bronchial cilia in children with recurrent respiratory tract infections. A comparative ultrastructural study.
Cystic Fibrosis
The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation.
Cysts
Centrosome migration into the Drosophila oocyte is independent of BicD and egl, and of the organisation of the microtubule cytoskeleton.
Cysts
Cutaneous ciliated cyst: a case report with immunohistochemical evidence for dynein in ciliated cells.
Cysts
Dynein light chain 1 functions in somatic cyst cells regulate spermatogonial divisions in Drosophila.
Cysts
Retrograde Intraflagellar Transport by Cytoplasmic Dynein-2 is Required for Outer Segment Extension in Vertebrate Photoreceptors but not Arrestin Translocation.
Cysts
Spectrosomes and fusomes anchor mitotic spindles during asymmetric germ cell divisions and facilitate the formation of a polarized microtubule array for oocyte specification in Drosophila.
Cysts
The microtubule motor cytoplasmic dynein is required for spindle orientation during germline cell divisions and oocyte differentiation in Drosophila.
Cysts
Zebrafish mutations affecting cilia motility share similar cystic phenotypes and suggest a mechanism of cyst formation that differs from pkd2 morphants.
Cytomegalovirus Infections
Advanced Microscopy for Liver and Gut Ultrastructural Pathology in Patients with MVID and PFIC Caused by MYO5B Mutations.
Cytomegalovirus Infections
Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3.
Cytomegalovirus Infections
Extraintestinal manifestations in an infant with microvillus inclusion disease: complications or features of the disease?
Cytomegalovirus Infections
MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity.
Cytomegalovirus Infections
Role of the endoplasmic reticulum chaperone BiP, SUN domain proteins, and dynein in altering nuclear morphology during human cytomegalovirus infection.
Deafness
A novel allele of myosin VIIa reveals a critical function for the C-terminal FERM domain for melanosome transport in retinal pigment epithelial cells.
Deafness
Chromosomal mapping of two members of the human dynein gene family to chromosome regions 7p15 and 11q13 near the deafness loci DFNA 5 and DFNA 11.
Deafness
Human deafness mutation E385D disrupts the mechanochemical coupling and subcellular targeting of myosin-1a.
Deafness
Myosin VI is required for the proper maturation and function of inner hair cell ribbon synapses.
Deafness
MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes.
Decompression Sickness
Computer simulation of flagellar movement: VII. Conventional but functionally different cross-bridge models for inner and outer arm dyneins can explain the effects of outer arm dynein removal.
Decompression Sickness
Different structural states of a microtubule cross-linking molecule, captured by quick-freezing motile axostyles in protozoa.
Decompression Sickness
Dynein-deficient flagella respond to increased viscosity with contrasting changes in power and recovery strokes.
Decompression Sickness
Induction of temporary beating in paralyzed flagella of Chlamydomonas mutants by application of external force.
Decompression Sickness
Methods for analysis of calcium/calmodulin signaling in cilia and flagella.
Decompression Sickness
Nucleotide-induced global conformational changes of flagellar dynein arms revealed by in situ analysis.
Decompression Sickness
The reactivation of demembranated human spermatozoa lacking outer dynein arms is independent of pH.
Decompression Sickness
Transient Pinning and Pulling: A Mechanism for Bending Microtubules.
Dehydration
Role of the ERK signaling pathway in regulating vasopressin secretion in dehydrated rats.
Dengue
The interaction of flavivirus M protein with light chain Tctex-1 of human dynein plays a role in late stages of virus replication.
Dextrocardia
Ciliary ultrastructure in primary ciliary dyskinesia and other chronic respiratory conditions: the relevance of microtubular abnormalities.
Dextrocardia
[Primary ciliary dyskinesia, immotile cilia syndrome, and Kartagener syndrome: diagnostic criteria]
Diabetes Mellitus, Type 1
Diabetes induces changes in KIF1A, KIF5B and dynein distribution in the rat retina: implications for axonal transport.
Down Syndrome
Altered expression of KIF17, a kinesin motor protein associated with NR2B trafficking, may mediate learning deficits in a Down syndrome mouse model.
Down Syndrome
Manifold decreased protein levels of matrin 3, reduced motor protein HMP and hlark in fetal Down's syndrome brain.
dynein atpase deficiency
A case of severe asthenozoospermia: a novel sperm tail defect of possible genetic origin identified by electron microscopy and immunocytochemistry.
dynein atpase deficiency
Cilia motility and structure in primary and secondary ciliary dyskinesia.
dynein atpase deficiency
Ciliary function analysis for the diagnosis of primary ciliary dyskinesia: advantages of ciliogenesis in culture.
dynein atpase deficiency
Successful intracytoplasmic sperm injection with spermatozoa from a patient with dysplasia of the fibrous sheath and chronic respiratory disease.
dynein atpase deficiency
The effects of ropy-1 mutation on cytoplasmic organization and intracellular motility in mature hyphae of Neurospora crassa.
dynein atpase deficiency
The secondary nature of ciliary (dis)orientation in secondary and primary ciliary dyskinesia.
dynein atpase deficiency
Ultrastructural expression of primary ciliary dyskinesia after ciliogenesis in culture.
Dyskinesias
Pregnancy after subzonal insemination with spermatozoa lacking outer dynein arms.
Dyskinesias
The dyskinetic cilia syndrome in childhood. Modifications of ultrastructural patterns.
Dyslexia
Rare variants in dynein heavy chain genes in two individuals with situs inversus and developmental dyslexia: a case report.
Ear Diseases
Discordant organ laterality in monozygotic twins with primary ciliary dyskinesia.
Encephalitis, Japanese
The interaction of flavivirus M protein with light chain Tctex-1 of human dynein plays a role in late stages of virus replication.
Familial Primary Pulmonary Hypertension
Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension.
Genetic Diseases, Inborn
Role of the Novel Hsp90 Co-Chaperones in Dynein Arms' Preassembly.
Genetic Diseases, Inborn
[The absence of the internal arms of dynein as a cause of the immotile cilia syndrome]
Glaucoma
Optic nerve dynein motor protein distribution changes with intraocular pressure elevation in a rat model of glaucoma.
Glaucoma
The expression of dynein light chain DYNLL1 (LC8-1) is persistently downregulated in glaucomatous rat retinal ganglion cells.
Glioblastoma
Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma.
Glioblastoma
Dynein Light Chain Protein Tctex1: A Novel Prognostic Marker and Molecular Mediator in Glioblastoma.
Glioblastoma
Expression of dynein, cytoplasmic 2, heavy chain 1 (DHC2) associated with glioblastoma cell resistance to temozolomide.
Glioblastoma
Highly efficient eradication of intracranial glioblastoma using Eg5 siRNA combined with HVJ envelope.
Glioma
Expression patterns of LIS1, dynein and their interaction partners dynactin, NudE, NudEL and NudC in human gliomas suggest roles in invasion and proliferation.
Glioma
Identification of histological markers for malignant glioma by genome-wide expression analysis: dynein, alpha-PIX and sorcin.
Glioma
KIF3C Promotes Proliferation, Migration, and Invasion of Glioma Cells by Activating the PI3K/AKT Pathway and Inducing EMT.
Glucose Intolerance
Antioxidant signaling involving the microtubule motor KIF12 is an intracellular target of nutrition excess in beta cells.
Hearing Loss
A novel MYO6 splice site mutation causes autosomal dominant sensorineural hearing loss type DFNA22 with a favourable outcome after cochlear implantation.
Hearing Loss
Cloning and developmental expression of nonmuscle myosin IIA (Myh9) in the mammalian inner ear.
Hearing Loss
Echolocating Whales and Bats Express the Motor Protein Prestin in the Inner Ear: A Potential Marker for Hearing Loss.
Hearing Loss
High frequency of the IVS2-2A>G DNA sequence variation in SLC26A5, encoding the cochlear motor protein prestin, precludes its involvement in hereditary hearing loss.
Hearing Loss
Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss.
Hearing Loss, Sensorineural
Loss of the Cochlear Amplifier Prestin Reduces Temporal Processing Efficacy in the Central Auditory System.
Hepatitis B
The chaperone dynein LL1 mediates cytoplasmic transport of empty and mature hepatitis B virus capsids.
Hepatitis C
The serine protease domain of hepatitis C viral NS3 activates RNA helicase activity by promoting the binding of RNA substrate.
Herpes Simplex
Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport.
Herpes Simplex
Herpes simplex virus type 2 membrane protein UL56 associates with the kinesin motor protein KIF1A.
Herpes Simplex
The herpes simplex virus 1 U(L)34 protein interacts with a cytoplasmic dynein intermediate chain and targets nuclear membrane.
Herpes Zoster
Dynein promotes porcine oocyte meiotic progression by maintaining cytoskeletal structures and cortical granule arrangement.
Heterotaxy Syndrome
A novel mutation of the axonemal dynein heavy chain gene 5 (DNAH5) in a Japanese neonate with asplenia syndrome.
Homozygous Familial Hypercholesterolemia
ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression.
Huntington Disease
A point mutation in the dynein heavy chain gene leads to striatal atrophy and compromises neurite outgrowth of striatal neurons.
Huntington Disease
Cytoplasmic dynein: a key player in neurodegenerative and neurodevelopmental diseases.
Huntington Disease
Dynein mutations impair autophagic clearance of aggregate-prone proteins.
Huntington Disease
Mutations in cytoplasmic dynein lead to a Huntington's disease-like defect in energy metabolism of brown and white adipose tissues.
Huntington Disease
Role of Dynein Axonemal Heavy Chain 6 Gene Expression as a Possible Biomarker for Huntington's Disease: a Translational Study.
Huntington Disease
Tandem reporter assay for myristoylated proteins post-translationally (TRAMPP) identifies novel substrates for post-translational myristoylation: PKC?, a case study.
Hydatidiform Mole
Absent inner dynein arms in a fetus with familial hydrocephalus-situs abnormality.
Hydrocephalus
Absent inner dynein arms in a fetus with familial hydrocephalus-situs abnormality.
Hydrocephalus
Dysfunction of axonemal dynein heavy chain Mdnah5 inhibits ependymal flow and reveals a novel mechanism for hydrocephalus formation.
Hydrocephalus
Histologic and Ultrastructural Findings in Dogs With Chronic Respiratory Disease Suspected of Ciliary Dyskinesia.
Hydrocephalus
Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome.
Hydrocephalus
Loss of function of axonemal dynein Mdnah5 causes primary ciliary dyskinesia and hydrocephalus.
Hydrocephalus
Mutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia.
Hypercholesterolemia
ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression.
Hypersensitivity
Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity.
Hypersensitivity
Mutations in genes encoding inner arm dynein heavy chains in Tetrahymena thermophila lead to axonemal hypersensitivity to Ca2+.
Hypothyroidism
Effect of thyroid hormone T3 on Myosin-Va expression in the central nervous system.
Infections
A "Driver Switchover" Mechanism of Influenza Virus Transport from Microfilaments to Microtubules.
Infections
A geminivirus replication protein interacts with a protein kinase and a motor protein that display different expression patterns during plant development and infection.
Infections
Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit.
Infections
African swine fever virus protein p54 interacts with the microtubular motor complex through direct binding to light-chain dynein.
Infections
Anterograde glycoprotein-dependent transport of newly generated rabies virus in dorsal root ganglion neurons.
Infections
Axonopathy Is Associated with Complex Axonal Transport Defects in a Model of Multiple Sclerosis.
Infections
Bicaudal D2 facilitates the cytoplasmic trafficking and nuclear import of HIV-1 genomes during infection.
Infections
Cellular and Viral Determinants of HSV-1 Entry and Intracellular Transport towards Nucleus of Infected Cells.
Infections
Cellular and viral protein interactions regulating I kappa B alpha activity during human retrovirus infection.
Infections
Chlamydia trachomatis utilizes the host cell microtubule network during early events of infection.
Infections
Cloning and characterization of cytoplasmic dynein intermediate chain in Fenneropenaeus chinensis and its essential role in white spot syndrome virus infection.
Infections
Dynamic Dissection of Dynein and Kinesin-1 Cooperatively Mediated Intercellular Transport of Porcine Epidemic Diarrhea Coronavirus along Microtubule Using Single Virus Tracking.
Infections
Dynein Light-Chain Dynlrb2 Is Essential for Murine Leukemia Virus Traffic and Nuclear Entry.
Infections
Equine herpesvirus type 1 (EHV-1) utilizes microtubules, dynein, and ROCK1 to productively infect cells.
Infections
Functional Evidence of the Involvement of the Dynein Light Chain DYNLRB2 in Murine Leukemia Virus Infection.
Infections
Genetic Variation in Autophagy-Related Genes Influences the Risk and Phenotype of Buruli Ulcer.
Infections
Golgi-associated BICD adaptors couple ER membrane penetration and disassembly of a viral cargo.
Infections
Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport.
Infections
HIV-1 capsid exploitation of the host microtubule cytoskeleton during early infection.
Infections
HIV-1 Engages a Dynein-Dynactin-BICD2 Complex for Infection and Transport to the Nucleus.
Infections
Integrated pathway analysis of nasopharyngeal carcinoma implicates the axonemal dynein complex in the Malaysian cohort.
Infections
Interaction of human dynein light chain 1 (DYNLL1) with enterochelin esterase (Salmonella typhimurium) and protective antigen (Bacillus anthraci) might be the potential cause of human infection.
Infections
Intracellular trafficking pathway of BK Virus in human renal proximal tubular epithelial cells.
Infections
Large-Scale Comparative Analysis of Codon Models Accounting for Protein and Nucleotide Selection.
Infections
Microtubules and Dynein Regulate Human Neutrophil Nuclear Volume and Hypersegmentation During H. pylori Infection.
Infections
Pentagalloylglucose Blocks the Nuclear Transport and the Process of Nucleocapsid Egress to Inhibit HSV-1 Infection.
Infections
Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein association.
Infections
Recognition of novel viral sequences that associate with the dynein light chain LC8 identified through a pepscan technique.
Infections
Role of the endoplasmic reticulum chaperone BiP, SUN domain proteins, and dynein in altering nuclear morphology during human cytomegalovirus infection.
Infections
The dynactin complex enhances the speed of microtubule-dependent motions of adenovirus both towards and away from the nucleus.
Infections
The herpesvirus VP1/2 protein is an effector of dynein-mediated capsid transport and neuroinvasion.
Infections
The interaction between flagellin and the glycosphingolipid Gb3 on host cells contributes to Bacillus cereus acute infection.
Infections
The interaction of flavivirus M protein with light chain Tctex-1 of human dynein plays a role in late stages of virus replication.
Infections
Two cases of primary ciliary dyskinesia with different responses to macrolide treatment.
Infections
Ultrastructural abnormalities of bronchial cilia in children with recurrent airway infections and bronchiectasis.
Infertility
A dynein light chain of sea urchin sperm flagella is a homolog of mouse Tctex 1, which is encoded by a gene of the t complex sterility locus.
Infertility
An axonemal dynein at the Hybrid Sterility 6 locus: implications for t haplotype-specific male sterility and the evolution of species barriers.
Infertility
DNAH1 gene mutations and their potential association with dysplasia of the sperm fibrous sheath and infertility in the Han Chinese population.
Infertility
Identification of a germ-cell-specific transcriptional repressor in the promoter of Tctex-1.
Infertility
Mutations in Outer Dynein Arm Heavy Chain DNAH9 Cause Motile Cilia Defects and Situs Inversus.
Infertility
Mutations in ZMYND10, a Gene Essential for Proper Axonemal Assembly of Inner and Outer Dynein Arms in Humans and Flies, Cause Primary Ciliary Dyskinesia.
Infertility
Splice-site mutations in the axonemal outer dynein arm docking complex gene CCDC114 cause primary ciliary dyskinesia.
Infertility
The Y chromosomal fertility factor Threads in Drosophila hydei harbors a functional gene encoding an axonemal dynein beta heavy chain protein.
Infertility
Wampa is a dynein subunit required for axonemal assembly and male fertility in Drosophila.
Infertility, Male
An axonemal dynein at the Hybrid Sterility 6 locus: implications for t haplotype-specific male sterility and the evolution of species barriers.
Infertility, Male
Defects in the cytoplasmic assembly of axonemal dynein arms cause morphological abnormalities and dysmotility in sperm cells leading to male infertility.
Infertility, Male
Drosophila Dynein intermediate chain gene, Dic61B, is required for spermatogenesis.
Infertility, Male
Drosophila melanogaster kl-3 and kl-5 Y-loops harbor triple-stranded nucleic acids.
Infertility, Male
ENU-induced mutant allele of Dnah1, ferf1, causes abnormal sperm behavior and fertilization failure in mice.
Infertility, Male
Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome.
Infertility, Male
Mice deficient in the axonemal protein Tektin-t exhibit male infertility and immotile-cilium syndrome due to impaired inner arm dynein function.
Infertility, Male
Mutations in DNAH1, which encodes an inner arm heavy chain dynein, lead to male infertility from multiple morphological abnormalities of the sperm flagella.
Infertility, Male
Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.
Infertility, Male
Mutations in Outer Dynein Arm Heavy Chain DNAH9 Cause Motile Cilia Defects and Situs Inversus.
Infertility, Male
Pregnancy after subzonal insemination with spermatozoa lacking outer dynein arms.
Infertility, Male
Relationship between DYNLT1 and Beclin1 expression and the fertilising potential of human spermatozoa.
Infertility, Male
The murine Dnali1 gene encodes a flagellar protein that interacts with the cytoplasmic dynein heavy chain 1.
Infertility, Male
The T complex distorter 2 candidate gene, Dnahc8, encodes at least two testis-specific axonemal dynein heavy chains that differ extensively at their amino and carboxyl termini.
Infertility, Male
Whole-exome sequencing of familial cases of multiple morphological abnormalities of the sperm flagella (MMAF) reveals new DNAH1 mutations.
Inflammatory Bowel Diseases
Mice lacking myosin IXb, an inflammatory bowel disease susceptibility gene, have impaired intestinal barrier function and superficial ulceration in the ileum.
Inflammatory Bowel Diseases
The association of MYO9B gene in Italian patients with inflammatory bowel diseases.
Influenza, Human
Immunohistochemistry of a cytoplasmic dynein (MAP 1C)-like molecule in rodent and human brain tissue: an example of molecular mimicry between cytoplasmic dynein and influenza A virus.
Influenza, Human
Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein association.
Influenza, Human
Role of the actin cytoskeleton during influenza virus internalization into polarized epithelial cells.
Influenza, Human
Selective and ATP-competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus.
Insulin Resistance
Myosin motor Myo1c and its receptor NEMO/IKK-gamma promote TNF-alpha-induced serine307 phosphorylation of IRS-1.
Intellectual Disability
Analysis of dynein intermediate chains, light intermediate chains and light chains in a cohort of hereditary peripheral neuropathies.
Intellectual Disability
DYNC1H1 mutation alters transport kinetics and ERK1/2-cFos signalling in a mouse model of distal spinal muscular atrophy.
Intellectual Disability
From the cell membrane to the nucleus: unearthing transport mechanisms for Dynein.
Intellectual Disability
Novel dynein DYNC1H1 neck and motor domain mutations link distal spinal muscular atrophy and abnormal cortical development.
Intellectual Disability
The clinical-phenotype continuum in DYNC1H1-related disorders-genomic profiling and proposal for a novel classification.
Intellectual Disability
Transport of Drosophila fragile X mental retardation protein-containing ribonucleoprotein granules by kinesin-1 and cytoplasmic dynein.
Ischemic Stroke
Evaluation of the genetic variants of kinesin motor protein in ischemic stroke.
Kartagener Syndrome
Atypical bronchial cilia in children with recurrent respiratory tract infections. A comparative ultrastructural study.
Kartagener Syndrome
Cell motility and microtubules in cultured fibroblasts from patients with Kartagener syndrome.
Kartagener Syndrome
Ciliary ultrastructure in a child with Kartagener's syndrome. A transmission electron microscopic study using tannic acid staining.
Kartagener Syndrome
Correlation of absent inner dynein arms and mucociliary clearance in a patient with Kartagener's syndrome.
Kartagener Syndrome
Evidence of congenitally nonfunctioning cilia in the tracheobronchial tract in two subjects.
Kartagener Syndrome
Kartagener's syndrome with absence of inner dynein arms of respiratory cilia.
Kartagener Syndrome
Kartagener's syndrome: a genetic defect affecting the function of cilia.
Kartagener Syndrome
Laterality disturbance and hypopituitarism. A case report of co-existing situs inversus totalis and combined pituitary hormone deficiency.
Kartagener Syndrome
Nine Japanese patients with immotile-dyskinetic cilia syndrome: an ultrastructural study using tannic acid-containing fixation.
Kartagener Syndrome
Problems in the differential diagnosis of Kartagener's syndrome and ATP-ase deficiency.
Kartagener Syndrome
Relationship between dynein arms and ciliary motility in Kartagener's syndrome.
Kartagener Syndrome
Screening for ciliary dyskinesia - a spectrum of defects of motility and structure.
Kartagener Syndrome
The dyskinetic cilia syndrome. Ciliary motility in immotile cilia syndrome.
Kartagener Syndrome
Ultrastructural abnormalities of bronchial cilia in children with recurrent airway infections and bronchiectasis.
Kartagener Syndrome
Ultrastructure and function of cilia and spermatozoa flagella in a patient with Kartagener's syndrome.
Kartagener Syndrome
Ultrastructure of bronchial epithelium in children with chronic or recurrent respiratory diseases.
Kartagener Syndrome
[Are ciliary abnormalities always present in Kartagener's syndrome? A study of 16 patients]
Kartagener Syndrome
[Ciliary changes with abscence of dynein arms in Kartagener's syndrome]
Kartagener Syndrome
[Kartagener syndrome with absence of internal dynein arms. Report of and commentary on a case]
Kartagener Syndrome
[Primary ciliary dyskinesia, immotile cilia syndrome, and Kartagener syndrome: diagnostic criteria]
Kidney Diseases
iMotor-CNN: Identifying molecular functions of cytoskeleton motor proteins using 2D convolutional neural network via Chou's 5-step rule.
Leukemia
Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein.
Leukemia
Dynein Light-Chain Dynlrb2 Is Essential for Murine Leukemia Virus Traffic and Nuclear Entry.
Leukemia
Functional Evidence of the Involvement of the Dynein Light Chain DYNLRB2 in Murine Leukemia Virus Infection.
Leukemia
Myosin-IIA regulates leukemia engraftment and brain infiltration in a mouse model of acute lymphoblastic leukemia.
Leukemia
Promyelocytic leukemia zinc finger protein localizes to the cochlear outer hair cells and interacts with prestin, the outer hair cell motor protein.
Lissencephaly
A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function.
Lissencephaly
Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase.
Lissencephaly
Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility.
Lissencephaly
Drosophila Lissencephaly-1 functions with Bic-D and dynein in oocyte determination and nuclear positioning.
Lissencephaly
Expression patterns of LIS1, dynein and their interaction partners dynactin, NudE, NudEL and NudC in human gliomas suggest roles in invasion and proliferation.
Lissencephaly
Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly.
Lissencephaly
Lis1 Acts as a "Clutch" between the ATPase and Microtubule-Binding Domains of the Dynein Motor.
Lissencephaly
Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration.
Lissencephaly
LIS1 at the microtubule plus end and its role in dynein-mediated nuclear migration.
Lissencephaly
Lissencephaly and LIS1: insights into the molecular mechanisms of neuronal migration and development.
Lissencephaly
mNUDC is required for plus-end-directed transport of cytoplasmic dynein and dynactins by kinesin-1.
Lissencephaly
Mutations in cytoplasmic dynein and its regulators cause malformations of cortical development and neurodegenerative diseases.
Lissencephaly
Ndel1 controls the dynein-mediated transport of vimentin during neurite outgrowth.
Lissencephaly
NudC-like protein 2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90.
Lissencephaly
Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration.
Lissencephaly
The essential role of LIS1, NDEL1 and Aurora-A in polarity formation and microtubule organization during neurogensis.
Lissencephaly
The lissencephaly protein Lis1 is present in motile mammalian cilia and requires outer arm dynein for targeting to Chlamydomonas flagella.
Lissencephaly
The role of cytoplasmic dynein in the human brain developmental disease lissencephaly.
Lissencephaly
The structure of the coiled-coil domain of Ndel1 and the basis of its interaction with Lis1, the causal protein of Miller-Dieker lissencephaly.
Lissencephaly
TUBA1A mutations identified in lissencephaly patients dominantly disrupt neuronal migration and impair dynein activity.
Lissencephaly
Type I platelet-activating factor acetylhydrolase catalytic subunits over-expression induces pleiomorphic nuclei and centrosome amplification.
Lissencephaly
[Molecular mechanism of lissencephaly--how LIS1 and NDEL1 regulate cytoplasmic dynein?]
Lissencephaly
[Molecular mechanism of lissencephaly: how LIS1 regulates cytoplasmic dynein]
Lung Neoplasms
Network analysis of differentially expressed smoking-associated mRNAs, lncRNAs and miRNAs reveals key regulators in smoking-associated lung cancer.
Lymphoma
Interaction of p59fyn kinase with the dynein light chain, Tctex-1, and colocalization during cytokinesis.
Lymphoma
The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma.
Lymphoma, B-Cell
Chlorpyrifos induced oxidative stress to promote apoptosis and autophagy through the regulation of miR-19a-AMPK axis in common carp.
Malformations of Cortical Development
Analysis of dynein intermediate chains, light intermediate chains and light chains in a cohort of hereditary peripheral neuropathies.
Malformations of Cortical Development
Mutations in cytoplasmic dynein and its regulators cause malformations of cortical development and neurodegenerative diseases.
Malformations of Cortical Development, Group II
Novel dynein DYNC1H1 neck and motor domain mutations link distal spinal muscular atrophy and abnormal cortical development.
Melanoma
A myosin-Va tail fragment sequesters dynein light chains leading to apoptosis in melanoma cells.
Melanoma
Melanoma dynein: evidence that dynein is a general "motor" for microtubule-associated cell motilities.
Microcephaly
Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages.
Motor Neuron Disease
Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders.
Motor Neuron Disease
Distal spinal and bulbar muscular atrophy caused by dynactin mutation.
Motor Neuron Disease
Dynein mutations impair autophagic clearance of aggregate-prone proteins.
Motor Neuron Disease
Kinesin and cytoplasmic dynein in spinal spheroids with motor neuron disease.
Motor Neuron Disease
Mice with a mutation in the dynein heavy chain 1 gene display sensory neuropathy but lack motor neuron disease.
Motor Neuron Disease
Mice with Mutation in Dynein Heavy Chain 1 Do Not Share the Same Tau Expression Pattern with Mice with SOD1-Related Motor Neuron Disease.
Motor Neuron Disease
Molecular basis for dyneinopathies reveals insight into dynein regulation and dysfunction.
Motor Neuron Disease
Mutation analysis of genes within the dynactin complex in a cohort of hereditary peripheral neuropathies.
Motor Neuron Disease
Neuromuscular junction defects in mice with mutation of dynein heavy chain 1.
Motor Neuron Disease
No association of DYNC1H1 with sporadic ALS in a case-control study of a northern European derived population: a tagging SNP approach.
Motor Neuron Disease
No association with common Caucasian genotypes in exons 8, 13 and 14 of the human cytoplasmic dynein heavy chain gene (DNCHC1) and familial motor neuron disorders.
Motor Neuron Disease
The Legs at odd angles (Loa) mutation in cytoplasmic dynein ameliorates mitochondrial function in SOD1G93A mouse model for motor neuron disease.
Motor Neuron Disease
Therapeutic targets for amyotrophic lateral sclerosis: current treatments and prospects for more effective therapies.
Motor Neuron Disease
Unraveling the mechanisms involved in motor neuron degeneration in ALS.
Movement Disorders
Identification of a homozygous splice site mutation in the dynein axonemal light chain 4 gene on 22q13.1 in a large consanguineous family from Pakistan with congenital mirror movement disorder.
Movement Disorders
Role of Myosin Va in the plasticity of the vertebrate neuromuscular junction in vivo.
Moyamoya Disease
6C.02: EXOME SEQUENCING IN SEVEN FAMILIES AND GENE-BASED ASSOCIATION STUDIES SUPPORT GENETIC HETEROGENEITY AND SUGGEST POSSIBLE CANDIDATES FOR FIBROMUSCULAR DYSPLASIA.
Moyamoya Disease
Exome sequencing in seven families and gene-based association studies indicate genetic heterogeneity and suggest possible candidates for fibromuscular dysplasia.
Multiple Sclerosis
A cytoskeleton motor protein genetic variant may exert a protective effect on the occurrence of multiple sclerosis: the janus face of the kinesin light-chain 1 56836CC genetic variant.
Multiple Sclerosis
Axonal motor protein KIF5A and associated cargo deficits in multiple sclerosis lesional and normal-appearing white matter.
Multiple Sclerosis
Reduced axonal motor protein expression in non-lesional grey matter in multiple sclerosis.
Muscle Weakness
Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres.
Muscle Weakness
Muscle cell and motor protein function in patients with a IIa myosin missense mutation (Glu-706 to Lys).
Muscle Weakness
Phenotypic and molecular insights into spinal muscular atrophy due to mutations in BICD2.
Muscular Atrophy
Lysosomal proliferation and distal degeneration in motor neurons expressing the G59S mutation in the p150Glued subunit of dynactin.
Muscular Atrophy, Spinal
A novel DYNC1H1 mutation causing spinal muscular atrophy with lower extremity predominance.
Muscular Atrophy, Spinal
DYNC1H1 mutation alters transport kinetics and ERK1/2-cFos signalling in a mouse model of distal spinal muscular atrophy.
Muscular Atrophy, Spinal
Dynein mutations associated with hereditary motor neuropathies impair mitochondrial morphology and function with age.
Muscular Atrophy, Spinal
From the cell membrane to the nucleus: unearthing transport mechanisms for Dynein.
Muscular Atrophy, Spinal
Morphological changes and altered expression of antioxidant proteins in a heterozygous dynein mutant; a mouse model of spinal muscular atrophy.
Muscular Atrophy, Spinal
Novel dynein DYNC1H1 neck and motor domain mutations link distal spinal muscular atrophy and abnormal cortical development.
Muscular Atrophy, Spinal
Novel mutations expand the clinical spectrum of DYNC1H1-associated spinal muscular atrophy.
Muscular Atrophy, Spinal
Phenotypic and molecular insights into spinal muscular atrophy due to mutations in BICD2.
Muscular Atrophy, Spinal
Role of Coiled-Coil Registry Shifts in the Activation of Human Bicaudal D2 for Dynein Recruitment upon Cargo Binding.
Muscular Atrophy, Spinal
The clinical-phenotype continuum in DYNC1H1-related disorders-genomic profiling and proposal for a novel classification.
Muscular Diseases
Accumulation of microtubule-based motor protein in a patient with colchicine myopathy.
Muscular Diseases
Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres.
Muscular Diseases
Impaired autophagy, chaperone expression, and protein synthesis in response to critical illness interventions in porcine skeletal muscle.
Muscular Diseases
The Effect of Nutritional Status in the Pathogenesis of Critical Illness Myopathy (CIM).
Muscular Dystrophy, Duchenne
Nucleocytoplasmic shuttling of the Duchenne muscular dystrophy gene product dystrophin Dp71d is dependent on the importin ?/? and CRM1 nuclear transporters and microtubule motor dynein.
Myopathies, Nemaline
[Results of nasal brushing in the study of ciliary conformation and function in chronic bronchopneumopathies in childhood]
Myositis
The kinesin superfamily motor protein KIF4 is associated with immune cell activation in idiopathic inflammatory myopathies.
Nasal Polyps
An Integrated Analysis of Radial Spoke Head and Outer Dynein Arm Protein Defects and Ciliogenesis Abnormality in Nasal Polyps.
Nasopharyngeal Carcinoma
Integrated pathway analysis of nasopharyngeal carcinoma implicates the axonemal dynein complex in the Malaysian cohort.
Nasopharyngeal Neoplasms
Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries.
Neoplasm Metastasis
High EGFR_1 Inside-Out Activated Inflammation-Induced Motility through SLC2A1-CCNB2-HMMR-KIF11-NUSAP1-PRC1-UBE2C.
Neoplasm Metastasis
Protease activated receptor 2 mediates tryptase-induced cell migration through MYO10 in colorectal cancer.
Neoplasm Metastasis
Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF-? signaling.
Neoplasm Metastasis
The motor protein KIF14 inhibits tumor growth and cancer metastasis in lung adenocarcinoma.
Neoplasms
Altered gene expression in glycolysis-cholesterol synthesis axis correlates with outcome of triple-negative breast cancer.
Neoplasms
An adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis complexes with dynein and a small GTPase.
Neoplasms
Cell death response to anti-mitotic drug treatment in cell culture, mouse tumor model and the clinic.
Neoplasms
Centromere-associated protein E: a motor that puts the brakes on the mitotic checkpoint.
Neoplasms
Chlorpyrifos induced oxidative stress to promote apoptosis and autophagy through the regulation of miR-19a-AMPK axis in common carp.
Neoplasms
Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors.
Neoplasms
Could microtubule inhibitors be the best choice of therapy in gastric cancer with high immune activity: mutant DYNC1H1 as a biomarker.
Neoplasms
Crystal structure of human dynein light chain Dnlc2A: Structural insights into the interaction with IC74.
Neoplasms
Delocalization of the microtubule motor Dynein from mitotic spindles by the human papillomavirus E7 oncoprotein is not sufficient for induction of multipolar mitoses.
Neoplasms
Depletion of kinesin 5B affects lysosomal distribution and stability and induces peri-nuclear accumulation of autophagosomes in cancer cells.
Neoplasms
Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes.
Neoplasms
Distinct retrograde microtubule motor sets drive early and late endosome transport.
Neoplasms
DYNC1I1 Promotes the Proliferation and Migration of Gastric Cancer by Up-Regulating IL-6 Expression.
Neoplasms
Dynein axonemal heavy chain 8 promotes androgen receptor activity and associates with prostate cancer progression.
Neoplasms
Dynein function and protein clearance changes in tumor cells induced by a Kunitz-type molecule, Amblyomin-X.
Neoplasms
Dynein light chain LC8 negatively regulates NF-kappaB through the redox-dependent interaction with IkappaBalpha.
Neoplasms
Effects of a preferential myosin loss on Ca2+ activation of force generation in single human skeletal muscle fibres.
Neoplasms
Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics.
Neoplasms
Exploring a potential allosteric inhibition mechanism in the motor domain of human Eg-5.
Neoplasms
High KIF2A expression predicts unfavorable prognosis in diffuse large B cell lymphoma.
Neoplasms
Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus.
Neoplasms
Human papillomavirus type 16 E7 oncoprotein engages but does not abrogate the mitotic spindle assembly checkpoint.
Neoplasms
Identification of histological markers for malignant glioma by genome-wide expression analysis: dynein, alpha-PIX and sorcin.
Neoplasms
Identification of mRNAs differentially expressed in lymphocytes following interleukin-2 activation.
Neoplasms
In silico whole-genome scanning of cancer-associated nonsynonymous SNPs and molecular characterization of a dynein light chain tumour variant.
Neoplasms
Inhibition of KIF22 suppresses cancer cell proliferation by delaying mitotic exit through upregulating CDC25C expression.
Neoplasms
Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells.
Neoplasms
Inhibition of RAD54B suppresses proliferation and promotes apoptosis in hepatoma cells.
Neoplasms
Initial testing of the CENP-E inhibitor GSK923295A by the pediatric preclinical testing program.
Neoplasms
Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein.
Neoplasms
KIF11 is required for proliferation and self-renewal of docetaxel resistant triple negative breast cancer cells.
Neoplasms
KIF15 upregulation promotes leiomyosarcoma cell growth via promoting USP15-mediated DEK deubiquitylation.
Neoplasms
KIF2A silencing inhibits the proliferation and migration of breast cancer cells and correlates with unfavorable prognosis in breast cancer.
Neoplasms
Motor protein function in skeletal abdominal muscle of cachectic cancer patients.
Neoplasms
Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis.
Neoplasms
Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries.
Neoplasms
Overexpression of the dynein light chain km23-1 in human ovarian carcinoma cells inhibits tumor formation in vivo and causes mitotic delay at prometaphase/metaphase.
Neoplasms
Protease activated receptor 2 mediates tryptase-induced cell migration through MYO10 in colorectal cancer.
Neoplasms
Relevance of aneuploidy for cancer therapies targeting the spindle assembly checkpoint and KIF18A.
Neoplasms
Role of NuMA in vertebrate cells: review of an intriguing multifunctional protein.
Neoplasms
Selective unresponsiveness to the inhibition of p38 MAPK activation by cAMP helps L929 fibroblastoma cells escape TNF-alpha-induced cell death.
Neoplasms
Specific role of cytoplasmic dynein in the mechanism of action of an antitumor molecule, Amblyomin-X.
Neoplasms
Suppression of motor protein KIF3C expression inhibits tumor growth and metastasis in breast cancer by inhibiting TGF-? signaling.
Neoplasms
The effector domain of human Dlg tumor suppressor acts as a switch that relieves autoinhibition of kinesin-3 motor GAKIN/KIF13B.
Neoplasms
The motor protein KIF14 inhibits tumor growth and cancer metastasis in lung adenocarcinoma.
Nephrosis, Lipoid
Mechanism Underlying Selective Albuminuria in Minimal Change Nephrotic Syndrome.
Nephrotic Syndrome
Mechanism Underlying Selective Albuminuria in Minimal Change Nephrotic Syndrome.
Nervous System Diseases
Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders.
Nervous System Diseases
Genotype and defects in microtubule-based motility correlate with clinical severity in KIF1A-associated neurological disorder.
Nervous System Diseases
Mutations in cytoplasmic dynein and its regulators cause malformations of cortical development and neurodegenerative diseases.
Neuroaxonal Dystrophies
Axonal spheroids in ovine neuroaxonal dystrophy are immunopositive to kinesin and dynein.
Neuroblastoma
Aging attenuates dynactin-dynein interaction: Down-regulation of dynein causes accumulation of endogenous tau and amyloid precursor protein in human neuroblastoma cells.
Neuroblastoma
MiRNA-335 Suppresses Neuroblastoma Cell Invasiveness By Direct Targeting of Multiple Genes from the non-Canonical TGF-? Signalling Pathway.
Neurodegenerative Diseases
A novel de novo mutation in DYNC1H1 gene underlying malformation of cortical development and cataract.
Neurodegenerative Diseases
A point mutation in the dynein heavy chain gene leads to striatal atrophy and compromises neurite outgrowth of striatal neurons.
Neurodegenerative Diseases
Analysis of dynein intermediate chains, light intermediate chains and light chains in a cohort of hereditary peripheral neuropathies.
Neurodegenerative Diseases
Axonal spheroids in ovine neuroaxonal dystrophy are immunopositive to kinesin and dynein.
Neurodegenerative Diseases
Axonal transport and neurodegenerative disease: vesicle-motor complex formation and their regulation.
Neurodegenerative Diseases
Axonal transport defects: a common theme in neurodegenerative diseases.
Neurodegenerative Diseases
Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders.
Neurodegenerative Diseases
Cytoplasmic dynein: a key player in neurodegenerative and neurodevelopmental diseases.
Neurodegenerative Diseases
Dynein c1h1, dynactin and syntaphilin expression in brain areas related to neurodegenerative diseases following exposure to rotenone.
Neurodegenerative Diseases
Dynein motors transport activated Trks to promote survival of target-dependent neurons.
Neurodegenerative Diseases
DYNLRB1 is essential for dynein mediated transport and neuronal survival.
Neurodegenerative Diseases
Establishing a novel knock-in mouse line for studying neuronal cytoplasmic dynein under normal and pathologic conditions.
Neurodegenerative Diseases
Internal Dynamics of Dynactin CAP-Gly Is Regulated by Microtubules and Plus End Tracking Protein EB1.
Neurodegenerative Diseases
Kinesin and dynein mechanics: measurement methods and research applications.
Neurodegenerative Diseases
Lysosomal proliferation and distal degeneration in motor neurons expressing the G59S mutation in the p150Glued subunit of dynactin.
Neurodegenerative Diseases
Molecular motors in neuronal development, intracellular transport and diseases.
Neurodegenerative Diseases
Mutation analysis of genes within the dynactin complex in a cohort of hereditary peripheral neuropathies.
Neurodegenerative Diseases
Mutations in cytoplasmic dynein and its regulators cause malformations of cortical development and neurodegenerative diseases.
Neurodegenerative Diseases
Neurodegeneration mutations in dynactin impair dynein-dependent nuclear migration.
Neurodegenerative Diseases
Rotenone-dependent changes of anterograde motor protein expression and mitochondrial mobility in brain areas related to neurodegenerative diseases.
Neurofibromatoses
The motor protein kinesin-1 links neurofibromin and merlin in a common cellular pathway of neurofibromatosis.
Neurologic Manifestations
Dominant transmission of de novo KIF1A motor domain variant underlying pure spastic paraplegia.
Neuromuscular Diseases
Modulation of Agrin and RhoA Pathways Ameliorates Movement Defects and Synapse Morphology in MYO9A-Depleted Zebrafish.
Niemann-Pick Disease, Type C
Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning.
Oculomotor Nerve Diseases
Congenital fibrosis of extraocular muscles type 1 with progression of ophthalmoplegia.
Otitis
Histologic and Ultrastructural Findings in Dogs With Chronic Respiratory Disease Suspected of Ciliary Dyskinesia.
Ototoxicity
Salicylate ototoxicity and its implications for cochlear microphonic potential generation.
Ovarian Neoplasms
A transforming growth factor-beta receptor-interacting protein frequently mutated in human ovarian cancer.
Ovarian Neoplasms
Effects of dynein light chain Tctex-type 3 on the biological behavior of ovarian cancer.
Ovarian Neoplasms
Lessons from border cell migration in the Drosophila ovary: A role for myosin VI in dissemination of human ovarian cancer.
Pancreatic Neoplasms
Ectopic expression of the microtubule-dependent motor protein Eg5 promotes pancreatic tumourigenesis.
Pancreatitis
The potential role of kinesin and dynein in Golgi scattering and cytoplasmic vacuole formation during acute experimental pancreatitis.
Papillomavirus Infections
Identification of the Dynein Light Chains required for Human Papillomavirus Infection.
Papillomavirus Infections
Identification of the dynein light chains required for human papillomavirus infection.
Paralysis
Congenital fibrosis of extraocular muscles type 1 with progression of ophthalmoplegia.
Paralysis
Genetic analysis of a novel tubulin mutation that redirects synaptic vesicle targeting and causes neurite degeneration in C. elegans.
Paralysis
Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: Underlying mechanisms.
Paraplegia
Mutation screen reveals novel variants and expands the phenotypes associated with DYNC1H1.
Paraplegia
Spastic paraplegia mutation N256S in the neuronal microtubule motor KIF5A disrupts axonal transport in a Drosophila HSP model.
Parkinson Disease
Alteration of dynein function affects ?-synuclein degradation via the autophagosome-lysosome pathway.
Parkinson Disease
Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease.
Parkinson Disease
Cytoplasmic dynein: a key player in neurodegenerative and neurodevelopmental diseases.
Parkinson Disease
Mutation analysis of genes within the dynactin complex in a cohort of hereditary peripheral neuropathies.
Pemphigoid, Bullous
[Comparison of urinary proteomics between steroid-sensitive and steroid-resistant minimal change nephrotic syndrome in children.]
Peripheral Nervous System Diseases
Analysis of dynein intermediate chains, light intermediate chains and light chains in a cohort of hereditary peripheral neuropathies.
Peripheral Nervous System Diseases
Association of the kinesin superfamily motor protein KIF1Balpha with postsynaptic density-95 (PSD-95), synapse-associated protein-97, and synaptic scaffolding molecule PSD-95/discs large/zona occludens-1 proteins.
Peripheral Nervous System Diseases
Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta.
Peripheral Nervous System Diseases
Mutations in cytoplasmic dynein and its regulators cause malformations of cortical development and neurodegenerative diseases.
Peripheral Nervous System Diseases
[Changes in expression of motor protein for axonal transport in nerve tissues of carbon disulfide-intoxicated rats].
Persistent Infection
Abnormal central complex is a marker of severity in the presence of partial ciliary defect.
Pheochromocytoma
Tianeptine interferes with microtubule organization and hormone secretion of pheochromocytoma cells.
Pneumonia
Atypical bronchial cilia in children with recurrent respiratory tract infections. A comparative ultrastructural study.
Pneumonia
Respiratory syncytial virus co-opts host mitochondrial function to favour infectious virus production.
Pneumonia, Viral
Atypical bronchial cilia in children with recurrent respiratory tract infections. A comparative ultrastructural study.
Polycystic Kidney Diseases
Loss of zinc finger MYND-type containing 10 (zmynd10) affects cilia integrity and axonemal localization of dynein arms, resulting in ciliary dysmotility, polycystic kidney and scoliosis in medaka (Oryzias latipes).
Polycystic Kidney, Autosomal Dominant
The ubiquitin conjugation system is involved in the disassembly of cilia and flagella.
Polydactyly
Mutations in DYNC2H1, the cytoplasmic dynein 2, heavy chain 1 motor protein gene, cause short-rib polydactyly type I, Saldino-Noonan type.
Polymicrogyria
Mutations in cytoplasmic dynein and its regulators cause malformations of cortical development and neurodegenerative diseases.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Myosin-IIA regulates leukemia engraftment and brain infiltration in a mouse model of acute lymphoblastic leukemia.
Pregnancy, Ectopic
Using dynein heavy chain 5 and creatine kinase levels in cervical fluid and blood for early diagnosing of ectopic pregnancy.
Prion Diseases
Prion disease incubation time is not affected in mice heterozygous for a dynein mutation.
Prostatic Neoplasms
Androgens modify therapeutic response to cabazitaxel in models of advanced prostate cancer.
Prostatic Neoplasms
Association between aberrant dynein cytoplasmic 1 light intermediate chain 1 expression levels, mucins and chemosensitivity in colorectal cancer.
Prostatic Neoplasms
Dynein axonemal heavy chain 8 promotes androgen receptor activity and associates with prostate cancer progression.
Prostatic Neoplasms
Identification of potential diagnostic markers of prostate cancer and prostatic intraepithelial neoplasia using cDNA microarray.
Prostatic Neoplasms
Inhibition of kinesin motor protein KIFC1 by AZ82 induces multipolar mitosis and apoptosis in prostate cancer cell.
Prostatic Neoplasms
KIF3a Promotes Proliferation and Invasion via Wnt Signaling in Advanced Prostate Cancer.
Pseudomonas Infections
Two cases of primary ciliary dyskinesia with different responses to macrolide treatment.
Pseudorabies
The Carboxyl Terminus of Tegument Protein pUL21 Contributes to Pseudorabies Virus Neuroinvasion.
Pseudorabies
The herpesvirus VP1/2 protein is an effector of dynein-mediated capsid transport and neuroinvasion.
Pulmonary Disease, Chronic Obstructive
Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Of dung and dynein arms: understanding COPD in nonsmokers.
Rabies
Anterograde glycoprotein-dependent transport of newly generated rabies virus in dorsal root ganglion neurons.
Rabies
Comparative pathogenesis of the SAD-L16 strain of rabies virus and a mutant modifying the dynein light chain binding site of the rabies virus phosphoprotein in young mice.
Rabies
Extensive attenuation of rabies virus by simultaneously modifying the dynein light chain binding site in the P protein and replacing Arg333 in the G protein.
Rabies
High throughput differentiation and screening of a library of mutant stem cell clones defines new host-based genes involved in rabies virus infection.
Rabies
Molecular basis for the interaction between rabies virus phosphoprotein P and the dynein light chain LC8: dissociation of dynein-binding properties and transcriptional functionality of P.
Rabies
The dynein light chain 8 binding motif of rabies virus phosphoprotein promotes efficient viral transcription.
Respiratory Tract Infections
Integrated pathway analysis of nasopharyngeal carcinoma implicates the axonemal dynein complex in the Malaysian cohort.
Respiratory Tract Infections
Loss of function of axonemal dynein Mdnah5 causes primary ciliary dyskinesia and hydrocephalus.
Respiratory Tract Infections
Wampa is a dynein subunit required for axonemal assembly and male fertility in Drosophila.
Retinitis Pigmentosa
Mutations in DNAH5 account for only 15% of a non-preselected cohort of patients with primary ciliary dyskinesia.
Retinitis Pigmentosa
Primary atrophic rhinitis: a scanning electron microscopic (SEM) study.
Retinitis Pigmentosa
Rhodopsin's carboxy-terminal cytoplasmic tail acts as a membrane receptor for cytoplasmic dynein by binding to the dynein light chain Tctex-1.
Retinitis Pigmentosa
RPGR is mutated in patients with a complex X linked phenotype combining primary ciliary dyskinesia and retinitis pigmentosa.
Retinoblastoma
Human papillomavirus type 16 E7 oncoprotein engages but does not abrogate the mitotic spindle assembly checkpoint.
Rhinitis
Long-term follow-up of the clinical relevance of short outer dynein arms in human nasal cilia.
Rotavirus Infections
Rotavirus viroplasm biogenesis involves microtubule-based dynein transport mediated by an interaction between NSP2 and dynein intermediate chain.
Sarcoma
Cross talk between Smad, MAPK, and actin in the etiology of pulmonary arterial hypertension.
Scoliosis
Coding Variants Coupled With Rapid Modeling in Zebrafish Implicate Dynein Genes, dnaaf1 and zmynd10, as Adolescent Idiopathic Scoliosis Candidate Genes.
Scoliosis
Loss of zinc finger MYND-type containing 10 (zmynd10) affects cilia integrity and axonemal localization of dynein arms, resulting in ciliary dysmotility, polycystic kidney and scoliosis in medaka (Oryzias latipes).
Scrapie
Prion disease incubation time is not affected in mice heterozygous for a dynein mutation.
Seizures
Pharmacogenetic Analysis Reveals a Post-Developmental Role for Rac GTPases in Caenorhabditis elegans GABAergic Neurotransmission.
Sinusitis
Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome.
Sinusitis
Long-term follow-up of the clinical relevance of short outer dynein arms in human nasal cilia.
Sinusitis
The immotile cilia syndrome: phase contrast light microscopy, scanning and transmission electron microscopy.
Situs Inversus
Axonemal dynein intermediate-chain gene (DNAI1) mutations result in situs inversus and primary ciliary dyskinesia (Kartagener syndrome).
Situs Inversus
Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome.
Situs Inversus
Identification of a homozygous splice site mutation in the dynein axonemal light chain 4 gene on 22q13.1 in a large consanguineous family from Pakistan with congenital mirror movement disorder.
Situs Inversus
Loss of function of axonemal dynein Mdnah5 causes primary ciliary dyskinesia and hydrocephalus.
Situs Inversus
Mutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia.
Situs Inversus
Mutations in Outer Dynein Arm Heavy Chain DNAH9 Cause Motile Cilia Defects and Situs Inversus.
Situs Inversus
Mutations in the DNAH11 (axonemal heavy chain dynein type 11) gene cause one form of situs inversus totalis and most likely primary ciliary dyskinesia.
Situs Inversus
Mutations of DNAH11 in patients with primary ciliary dyskinesia with normal ciliary ultrastructure.
Situs Inversus
Nine Japanese patients with immotile-dyskinetic cilia syndrome: an ultrastructural study using tannic acid-containing fixation.
Situs Inversus
Primary ciliary dyskinesia: a genome-wide linkage analysis reveals extensive locus heterogeneity.
Situs Inversus
Rare variants in dynein heavy chain genes in two individuals with situs inversus and developmental dyslexia: a case report.
Situs Inversus
Reflection of structural abnormality in the axoneme of respiratory cilia in the clinical features of immotile cilia syndrome.
Situs Inversus
The immotile cilia syndrome: phase contrast light microscopy, scanning and transmission electron microscopy.
Situs Inversus
Wampa is a dynein subunit required for axonemal assembly and male fertility in Drosophila.
Situs Inversus
[Ultrastructural study of bronchial mucosa in suspicion of ciliary dyskinesia]
Spastic Paraplegia, Hereditary
A Novel Mutation in Motor Domain of KIF5A Associated With an HSP/Axonal Neuropathy Phenotype.
Spastic Paraplegia, Hereditary
Generation of the CRISPR/Cas9-mediated KIF1C knock-out human iPSC line HIHRSi003-A-1.
Spastic Paraplegia, Hereditary
Motor protein mutations cause a new form of hereditary spastic paraplegia.
Spastic Paraplegia, Hereditary
Mutation analysis of genes within the dynactin complex in a cohort of hereditary peripheral neuropathies.
Spastic Paraplegia, Hereditary
Theoretical Investigations of the Role of Mutations in Dynamics of Kinesin Motor Proteins.
Starvation
Cytoplasmic dynein undergoes intracellular redistribution concomitant with phosphorylation of the heavy chain in response to serum starvation and okadaic acid.
Starvation
Regulation of the intracellular distribution of cytoplasmic dynein by serum factors and calcium.
Starvation
Somatic insulin signaling regulates a germline starvation response in Drosophila egg chambers.
Stomach Neoplasms
Somatic mutation of DNAH genes implicated higher chemotherapy response rate in gastric adenocarcinoma patients.
Stroke
A single-headed recombinant fragment of Dictyostelium cytoplasmic dynein can drive the robust sliding of microtubules.
Stroke
Calcium-dependent bidirectional power stroke of the dynein arms in sea urchin sperm axonemes.
Stroke
Coarse-grained modeling of the structural states and transition underlying the powerstroke of dynein motor domain.
Stroke
Dynein-deficient flagella respond to increased viscosity with contrasting changes in power and recovery strokes.
Stroke
Early stages of the recovery stroke in myosin II studied by molecular dynamics simulations.
Stroke
Energetic considerations of ciliary beating and the advantage of metachronal coordination.
Stroke
Kinetic characterization of tail swing steps in the ATPase cycle of Dictyostelium cytoplasmic dynein.
Stroke
Splitting the ciliary axoneme: implications for a "switch-point" model of dynein arm activity in ciliary motion.
Stroke
Step Sizes and Rate Constants of Single-headed Cytoplasmic Dynein Measured with Optical Tweezers.
Stroke
Synchronous tRNA movements during translocation on the ribosome are orchestrated by elongation factor G and GTP hydrolysis.
Stroke
The mechanism of the converter domain rotation in the recovery stroke of myosin motor protein.
Stroke
Twirling motion of actin filaments in gliding assays with nonprocessive Myosin motors.
Stroke
Two independent switches regulate cytoplasmic dynein's processivity and directionality.
Tetanus
Myosin Va and microtubule-based motors are required for fast axonal retrograde transport of tetanus toxin in motor neurons.
Trypanosomiasis, African
Trypanin, a component of the flagellar Dynein regulatory complex, is essential in bloodstream form African trypanosomes.
tubulin-glutamate ligase deficiency
Tubulin glutamylation regulates ciliary motility by altering inner dynein arm activity.
Usher Syndromes
Human myosin VIIa is a very slow processive motor protein on various cellular actin structures.
Vaccinia
Interaction of poxvirus intracellular mature virion proteins with the TPR domain of kinesin light chain in live infected cells revealed by two photon-induced Fluorescence Resonance Energy Transfer Fluorescence Lifetime Imaging Microscopy.
Vaccinia
Loss of cytoskeletal transport during egress critically attenuates ectromelia virus infection in vivo.
Vaccinia
Vaccinia virus A36R membrane protein provides a direct link between intracellular enveloped virions and the microtubule motor kinesin.
Virus Diseases
African swine fever virus protein p54 interacts with the microtubular motor complex through direct binding to light-chain dynein.
Virus Diseases
Cloning and characterization of cytoplasmic dynein intermediate chain in Fenneropenaeus chinensis and its essential role in white spot syndrome virus infection.
Virus Diseases
Dynein Regulators Are Important for Ecotropic Murine Leukemia Virus Infection.
Virus Diseases
Flaviviral helicase: insights into the mechanism of action of a motor protein.
Virus Diseases
Functional Evidence of the Involvement of the Dynein Light Chain DYNLRB2 in Murine Leukemia Virus Infection.
Virus Diseases
Hepatitis C virus promotes virion secretion through cleavage of the Rab7 adaptor protein RILP.
Virus Diseases
Intracellular trafficking of a dynein-based nanoparticle designed for gene delivery.
Virus Diseases
Recognition of novel viral sequences that associate with the dynein light chain LC8 identified through a pepscan technique.
Virus Diseases
Small peptide inhibitors disrupt a high-affinity interaction between cytoplasmic dynein and a viral cargo protein.
Virus Diseases
Smoke and viral infection cause cilia loss detectable by bronchoalveolar lavage cytology and dynein ELISA.
Virus Diseases
The association of viral proteins with host cell dynein components during virus infection.
Virus Diseases
The dynein microtubule motor: architecture and force generation, cellular roles of dynein light chain DYNLL and role of dynein during virus infection.
Williams Syndrome
Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice.
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SEQUENCE DB
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
cytoplasmic dynein is an AAA+ motor responsible for intracellular cargo transport and force generation along microtubules
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). DYHC_YEAST
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
4092
0
471348
Swiss-Prot
-
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
DeWitt, M.A.; Cypranowska, C.A.; Cleary, F.B.; Belyy, V.; Yildiz, A.
The AAA3 domain of cytoplasmic dynein acts as a switch to facilitate microtubule release
Nat. Struct. Mol. Biol.
22
73-80
2015
Saccharomyces cerevisiae (P36022), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 (P36022)
brenda
Nicholas, M.P.; Berger, F.; Rao, L.; Brenner, S.; Cho, C.; Gennerich, A.
Cytoplasmic dynein regulates its attachment to microtubules via nucleotide state-switched mechanosensing at multiple AAA domains
Proc. Natl. Acad. Sci. USA
112
6371-6376
2015
Saccharomyces cerevisiae (P36022), Saccharomyces cerevisiae ATCC 204508 (P36022)
brenda
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Release 2023.1 (January 2023)
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