Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 5.6.1.1 - microtubule-severing ATPase and Organism(s) Danio rerio and UniProt Accession Q6NW58

for references in articles please use BRENDA:EC5.6.1.1
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
A member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Danio rerio
UNIPROT: Q6NW58
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
hide
The taxonomic range for the selected organisms is: Danio rerio
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
hide
n
ATP
+
n
H2O
+
a microtubule
=
n
ADP
+
n
phosphate
+
(n+1)
alpha/beta tubulin heterodimers
n
+
n
+
a microtubule
=
n
+
n
+
(n+1)
alpha/beta tubulin heterodimers
Synonyms
spastin, katanin, scinderin, kinesin spindle protein, mei-1, adseverin, katanin p60, microtubule-severing protein, microtubule-stimulated atpase, p60-katanin, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
microtubule severing protein
shares homology with katanin
katanin
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
-
SYSTEMATIC NAME
IUBMB Comments
ATP phosphohydrolase (tubulin-dimerizing)
A member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + H2O
ADP + phosphate
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + H2O
ADP + phosphate
show the reaction diagram
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
spg4atg1
morpholino antisense oligonucleotide for blocking translation of spg4 mRNA
-
spg4exon7
morpholino antisense oligonucleotide for blocking correct splicing of spg4 mRNA
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
Uniprot
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
SPAST_DANRE
570
0
63086
Swiss-Prot
Mitochondrion (Reliability: 2)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
TA-cloned for sequencing, subcloned into pFLAG-CMV-6a for transfection of HEK293 cells
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
mutations in the SPG4 gene, spastin is the SPG4 gene product, are the most common cause of autosomal dominant hereditary spastic paraplegia, HSP
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wood, J.D.; Landers, J.A.; Bingley, M.; McDermott, C.J.; Thomas-McArthur, V.; Gleadall, L.J.; Shaw, P.J.; Cunliffe, V.T.
The microtubule-severing protein Spastin is essential for axon outgrowth in the zebrafish embryo
Hum. Mol. Genet.
15
2763-2771
2006
Danio rerio (Q6NW58), Danio rerio
Manually annotated by BRENDA team