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EC Tree
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
3-carboxy-5-oxo-2,5-dihydrofuran-2-acetate (decyclizing), 3-Carboxy-cis,cis-muconate lactonizing enzyme, 3-Carboxy-cis-cis-muconate cyclase, 3-Carboxymuconate cyclase, CMLE, Cyclase, carboxy-cis,cis-muconate-,
more
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3-carboxy-5-oxo-2,5-dihydrofuran-2-acetate (decyclizing)
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-
-
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3-Carboxy-cis,cis-muconate lactonizing enzyme
3-Carboxy-cis-cis-muconate cyclase
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3-Carboxymuconate cyclase
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Cyclase, carboxy-cis,cis-muconate-
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3-Carboxy-cis,cis-muconate lactonizing enzyme
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3-Carboxy-cis,cis-muconate lactonizing enzyme
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-
CMLE
-
-
-
-
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3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate
3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate
syn-1,2 addition-elimination reaction
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3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate
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-
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-
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elimination/addition
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intramolecular
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3-carboxy-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)
-
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3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
?
3-Carboxy-cis,cis-muconate
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
cis,cis-Muconate
5-Oxo-2,5-dihydrofuran-2-acetate
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-
?
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
?
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enzyme of the protocatechuate catabolic pathway
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-
?
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
?
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coordinate induction of 3-carboxymuconate cyclase, 3-carboxymuconolactone hydrolase and 3-oxoadipate CoA-transferase by either protocatechuate or p-hydroxybenzoate
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-
?
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
?
-
enzyme of the protocatechuate branch of the 3-oxoadipate pathway
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-
?
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
?
-
3-carboxymuconate cyclase and 3-carboxymuconolactone hydrolase are under coordinate control
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-
?
3-Carboxy-cis,cis-muconate
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
-
-
-
-
?
3-Carboxy-cis,cis-muconate
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
-
-
-
-
?
3-Carboxy-cis,cis-muconate
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
-
-
-
-
?
3-Carboxy-cis,cis-muconate
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
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-
-
-
?
3-Carboxy-cis,cis-muconate
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
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-
-
-
?
3-Carboxy-cis,cis-muconate
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
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-
-
-
?
3-Carboxy-cis,cis-muconate
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
-
-
3-carboxymuconolactone
?
3-Carboxy-cis,cis-muconate
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
-
-
-
-
?
3-Carboxy-cis,cis-muconate
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
-
-
-
-
?
3-Carboxy-cis,cis-muconate
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
-
-
-
-
?
3-Carboxy-cis,cis-muconate
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
-
-
-
-
?
3-Carboxy-cis,cis-muconate
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
-
-
-
-
?
3-Carboxy-cis,cis-muconate
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
-
-
-
-
?
3-Carboxy-cis,cis-muconate
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
-
-
-
-
?
3-Carboxy-cis,cis-muconate
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
-
r
-
-
?
3-Carboxy-cis,cis-muconate
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
-
-
-
-
?
3-Carboxy-cis,cis-muconate
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
-
-
-
-
?
3-Carboxy-cis,cis-muconate
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
-
-
-
-
?
3-Carboxy-cis,cis-muconate
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
-
-
-
-
?
3-Carboxy-cis,cis-muconate
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
-
-
-
-
?
3-Carboxy-cis,cis-muconate
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
-
-
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
?
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
?
-
enzyme of the protocatechuate catabolic pathway
-
-
?
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
?
-
coordinate induction of 3-carboxymuconate cyclase, 3-carboxymuconolactone hydrolase and 3-oxoadipate CoA-transferase by either protocatechuate or p-hydroxybenzoate
-
-
?
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
?
-
enzyme of the protocatechuate branch of the 3-oxoadipate pathway
-
-
?
3-Carboxy-5-oxo-2,5-dihydrofuran-2-acetate
?
-
3-carboxymuconate cyclase and 3-carboxymuconolactone hydrolase are under coordinate control
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-
?
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Ca2+
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contains 0.06 M to 0.3 M of Ca2+ per mol of subunit
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2-Chloro-4-methylmuconolactone
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non-competitive
3-carboxy-cis,cis-muconate
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substrate inhibition at concentration exceeding 0.070 mM
3-chloromuconate
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competitive
3-Chloromuconolactone
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non-competitive
3-methylmuconate
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competitive
BO33-
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negligible effect near the pH optimum but inhibits to a greater extent on the acid side of the optimum
ethoxyformic anhydride
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irreversible, presence of the competitive inhibitors cis-aconitate, trans-aconitate and cis,cis-muconate conferrs some protection
H2PO2-
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negligible effect near the pH optimum but inhibits to a greater extent on the acid side of the optimum
phosphate
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negligible effect near the pH optimum but inhibits to a greater extent on the acid side of the optimum
S2O32-
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negligible effect near the pH optimum but inhibits to a greater extent on the acid side of the optimum
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Sporotrichosis
Proteomics-Based Characterization of the Humoral Immune Response in Sporotrichosis: Toward Discovery of Potential Diagnostic and Vaccine Antigens.
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0.0103 - 0.057
3-carboxy-cis,cis-muconate
26.2
cis,cis-muconate
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recombinant enzyme expressed in E. coli
0.0103
3-carboxy-cis,cis-muconate
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recombinant enzyme expressed in E. coli
0.0207
3-carboxy-cis,cis-muconate
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-
0.057
3-carboxy-cis,cis-muconate
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-
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360 - 382
3-carboxy-cis,cis-muconate
360
3-carboxy-cis,cis-muconate
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-
382
3-carboxy-cis,cis-muconate
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recombinant enzyme expressed in E. coli
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600
-
recombinant enzyme expressed in Escherichia coli
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brenda
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brenda
var. glaber
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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brenda
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malfunction
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deletion mutant cannot catabolize phenolic compounds known to be degraded via the beta-ketoadipate pathway. Mutant is impaired in root invasion and is nonpathogenic, even though it shows normal superficial root colonization
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CMLE_NEUCR
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
366
0
41329
Swiss-Prot
other Location (Reliability: 4 )
A0A0T8EFF2_STREE
337
0
37693
TrEMBL
-
Q1GB62_LACDA
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / BCRC 10696 / JCM 1002 / NBRC 13953 / NCIMB 11778 / NCTC 12712 / WDCM 00102 / Lb 14)
336
0
37298
TrEMBL
-
A0A0U5F4H7_9PROT
434
0
46638
TrEMBL
-
A0A4J2T274_STREE
337
0
37785
TrEMBL
-
A0A654UAZ6_STREE
264
0
29629
TrEMBL
-
A0A4J2AGP6_STREE
337
0
37784
TrEMBL
-
A0A064C348_STREE
337
0
37724
TrEMBL
-
D2BNA9_LACLK
Lactococcus lactis subsp. lactis (strain KF147)
341
0
37302
TrEMBL
-
A0A4J0IZ32_STREE
337
0
37756
TrEMBL
-
A0A0T8BV12_STREE
337
0
37727
TrEMBL
-
A0A4L8IUI8_STREE
337
0
37787
TrEMBL
-
H9C592_FUSOX
364
0
41106
TrEMBL
Secretory Pathway (Reliability: 5 )
A0A0A8R5G0_9ACTN
349
0
38268
TrEMBL
-
A3RXB8_RALSL
418
0
44465
TrEMBL
-
A0A380JEW9_STRDO
338
0
37619
TrEMBL
-
D7GHV2_PROFC
Propionibacterium freudenreichii subsp. shermanii (strain ATCC 9614 / DSM 4902 / CIP 103027 / NCIMB 8099 / CIRM-BIA1)
349
0
38268
TrEMBL
-
A0A0T8TLP8_9STRE
337
0
37667
TrEMBL
-
A0A4J2B976_STREE
337
0
37730
TrEMBL
-
A0A4J2DJJ7_STREE
337
0
37741
TrEMBL
-
A0A654UYR7_STREE
337
0
37756
TrEMBL
-
S6D846_ACEPA
420
0
44790
TrEMBL
-
A0A4J1PZV8_STREE
337
0
37789
TrEMBL
-
A0A0F8BK18_CERFI
1161
0
129760
TrEMBL
Secretory Pathway (Reliability: 5 )
A0A0B7LH11_STREE
337
0
37757
TrEMBL
-
A0A4N1FMQ1_STREE
337
0
37747
TrEMBL
-
Q5FUT3_GLUOX
Gluconobacter oxydans (strain 621H)
423
0
44681
TrEMBL
-
A0A4J0R9X7_STREE
337
0
37791
TrEMBL
-
A0A1W2TJF4_ROSNE
361
0
40343
TrEMBL
other Location (Reliability: 5 )
D3H9K2_STRM6
Streptococcus mitis (strain B6)
337
0
37703
TrEMBL
-
A0A4L8MFQ7_STREE
337
0
37771
TrEMBL
-
A0A4F8JKL5_STREE
337
0
37787
TrEMBL
-
A2QAI9_ASPNC
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
368
0
41311
TrEMBL
other Location (Reliability: 5 )
A0A4J1VCA3_STREE
337
0
37699
TrEMBL
-
A0A0B7M8J8_STREE
337
0
37727
TrEMBL
-
A0A111MTR2_STREE
337
0
37698
TrEMBL
-
A0A4J1S045_STREE
337
0
37757
TrEMBL
-
A0A4J6YLW0_STREE
337
0
37756
TrEMBL
-
U3PRP6_9PEZI
412
0
43180
TrEMBL
Secretory Pathway (Reliability: 2 )
A0A6I3T7Q0_STREE
337
0
37697
TrEMBL
-
A0A4M9XSH2_STREE
337
0
37672
TrEMBL
-
B8MT79_TALSN
Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)
371
0
41820
TrEMBL
Mitochondrion (Reliability: 5 )
G0L8P3_ZOBGA
Zobellia galactanivorans (strain DSM 12802 / CCUG 47099 / CIP 106680 / NCIMB 13871 / Dsij)
383
0
41605
TrEMBL
-
A0A084FZ43_PSEDA
1219
0
135390
TrEMBL
other Location (Reliability: 5 )
A0A380KT90_STRMT
337
0
37696
TrEMBL
-
G0AID8_COLFT
Collimonas fungivorans (strain Ter331)
410
0
44461
TrEMBL
-
A0A0T8U4Q0_9STRE
337
0
37672
TrEMBL
-
U3PUQ3_SPOSC
413
0
43379
TrEMBL
Secretory Pathway (Reliability: 1 )
A0A0E9GYW1_STREE
337
0
37741
TrEMBL
-
J9VY29_LACBU
347
0
38388
TrEMBL
-
J0YEX9_9STRE
337
0
37567
TrEMBL
-
A0A4U9Y218_STRMT
337
0
37652
TrEMBL
-
A0A0T8ZWR8_STREE
337
0
37720
TrEMBL
-
A0A4J1PNC1_STREE
337
0
37788
TrEMBL
-
A0A4J2CHK5_STREE
337
0
37766
TrEMBL
-
S3MVG7_PSESY
390
0
42691
TrEMBL
-
A0A068VU86_PROFF
349
0
38268
TrEMBL
-
A0A4N6QWH5_STREE
337
0
37815
TrEMBL
-
A0A4I9MXU3_STREE
337
0
37741
TrEMBL
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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191000
-
high-speed equilibrium sedimentation
24000
-
8 * 24000, equilibrium sedimentation in presence of 5 M guanidine hydrochloride and 2-mercaptoethanol, SDS-PAGE
41000
-
4 * 41000, SDS-PAGE
41200
-
4 * 41200, calculation from nucleotide sequence
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octamer
-
8 * 24000, equilibrium sedimentation in presence of 5 M guanidine hydrochloride and 2-mercaptoethanol, SDS-PAGE
tetramer
-
4 * 41000, SDS-PAGE
tetramer
-
4 * 41200, calculation from nucleotide sequence
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glycoprotein
-
hexose composition of 9.54% which can be equivalent to 14.2 residues per polypeptide chain of MW 24000. An N-acetylglucosamine concentration of 2.8% is determined which can be equivalent to 3.9 residues per polypeptide chain
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rose-bengal-sensitized photooxidation
-
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stable for over 9 months in the intact mycelium
-
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-
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expression in Escherichia coli
-
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Thatcher, D.R.; Cain, R.B.
Metabolism of aromatic compounds by fungi. 1. Purification and physical properties of 3-carboxy-cis-cis-muconate cyclase from Aspergillus niger
Eur. J. Biochem.
48
549-556
1974
Aspergillus niger
brenda
Thatcher, D.R.; Cain, R.B.
Metabolism of aromatic compounds by fungi. 2. Subunit structure of the 3-carboxy-cis-cis-muconate cyclase of Aspergillus niger
Eur. J. Biochem.
48
557-562
1974
Aspergillus niger
brenda
Cook, K.A.; Cain, R.B.
Regulation of aromatic metabolism in the fungi: metabolic control of the 3-oxoadipate pathway in the yeast Rhodotorula mucilaginosa
J. Gen. Microbiol.
85
37-50
1974
Rhodotorula mucilaginosa
brenda
Huber, T.J.; Street, J.R.; Bull, A.T.; Cook, K.A.; Cain, R.B.
Aromatic metabolism in the fungi. Growth of Rhodotorula mucilaginosa, in p-hydroxybenzoate-limited chemostats and the effect of growth rate on the synthesis of enzymes of the 3-oxoadipate pathway
Arch. Microbiol.
102
139-144
1975
Rhodotorula mucilaginosa
brenda
Thatcher, D.R.; Cain, R.B.
Metabolism of aromatic compounds by fungi. Kinetic properties and mechanism of 3-carboxy-cis,cis-muconate cyclase from Aspergillus niger
Eur. J. Biochem.
56
193-204
1975
Aspergillus niger
brenda
Cook, K.A.; Cain R.B.
Enzymes of the 3-oxoadipate pathway in fungi: a serological study of 3-carboxymuconate cyclase (lactonizing enzyme) in fungi and its possible taxonomic significance
J. Gen. Microbiol.
102
81-94
1977
Aspergillus amstelodami, Aspergillus fischeri, Aspergillus flavus, Aspergillus nidulans, Aspergillus niger, Aspergillus oryzae, Aspergillus sydowii, Aspergillus terreus, Amorphotheca resinae, Trichoderma deliquescens, Clonostachys rosea, Kernia nitida, Monascus ruber, Byssochlamys spectabilis, Penicilliopsis clavariiformis, Penicillium capsulatum, Penicillium commune, Penicillium terrestre
-
brenda
Mazur, P.; Henzel, W.J.; Mattoo, S.; Kozarich, J.W.
3-Carboxy-cis-cis-muconate lactonizing enzyme from Neurospora crassa: an alternate cycloisomerase motif
J. Bacteriol.
176
1718-1728
1994
Aspergillus niger, Neurospora crassa
brenda
Michielse, C.B.; Reijnen, L.; Olivain, C.; Alabouvette, C.; Rep, M.
Degradation of aromatic compounds through the alpha-ketoadipate pathway is required for pathogenicity of the tomato wilt pathogen Fusarium oxysporum f. sp. lycopersici
Mol. Plant Pathol.
13
1089-1100
2012
Fusarium oxysporum
brenda
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