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Synonyms
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prenyltransferase and squalene oxidase repeat protein
HPS:F171A
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mutant F171A of class II diterpene cyclase Rv3377c
HPS:F171A
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mutant F171A of class II diterpene cyclase Rv3377c
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prenyltransferase and squalene oxidase repeat protein
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prenyltransferase and squalene oxidase repeat protein
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SCLAV_p0490
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geranylgeranyl diphosphate = (13E)-labda-7,13-dien-15-yl diphosphate
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(13E)-labda-7,13-dien-15-yl-diphosphate lyase (ring-opening)
Isolated from the bacterium Streptomyces clavuligerus.
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geranylgeranyl diphosphate
(13E)-labda-7,13-dien-15-yl diphosphate
geranylgeranyl diphosphate
halima-5,13-dienyl diphosphate + labda-8,13-dienyl diphosphate + labda-7,13-dienyl diphosphate + ?
geranylgeranyl diphosphate
(13E)-labda-7,13-dien-15-yl diphosphate
Substrates: -
?
geranylgeranyl diphosphate
(13E)-labda-7,13-dien-15-yl diphosphate
Substrates: -
?
geranylgeranyl diphosphate
halima-5,13-dienyl diphosphate + labda-8,13-dienyl diphosphate + labda-7,13-dienyl diphosphate + ?
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Substrates: the enzyme produces small amounts of halima-5,13-dienyl diphosphate and labda-8,13-dienyl diphosphate, along with trace amounts of labda-7,13-dienyl diphosphate, as well as an unknown product
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geranylgeranyl diphosphate
halima-5,13-dienyl diphosphate + labda-8,13-dienyl diphosphate + labda-7,13-dienyl diphosphate + ?
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Substrates: the enzyme produces small amounts of halima-5,13-dienyl diphosphate and labda-8,13-dienyl diphosphate, along with trace amounts of labda-7,13-dienyl diphosphate, as well as an unknown product
?
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geranylgeranyl diphosphate
halima-5,13-dienyl diphosphate + labda-8,13-dienyl diphosphate + labda-7,13-dienyl diphosphate + ?
geranylgeranyl diphosphate
halima-5,13-dienyl diphosphate + labda-8,13-dienyl diphosphate + labda-7,13-dienyl diphosphate + ?
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Substrates: the enzyme produces small amounts of halima-5,13-dienyl diphosphate and labda-8,13-dienyl diphosphate, along with trace amounts of labda-7,13-dienyl diphosphate, as well as an unknown product
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geranylgeranyl diphosphate
halima-5,13-dienyl diphosphate + labda-8,13-dienyl diphosphate + labda-7,13-dienyl diphosphate + ?
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Substrates: the enzyme produces small amounts of halima-5,13-dienyl diphosphate and labda-8,13-dienyl diphosphate, along with trace amounts of labda-7,13-dienyl diphosphate, as well as an unknown product
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Mg2+
assay in presence of
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UniProt
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UniProt
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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physiological function
SCLAV_p0490 catalyzes the generation of labda-8(17),13-dienyl diphosphate by the release of a proton at H-7 in the C8-carbonium ion of (+)-copalyl diphosphate
physiological function
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SCLAV_p0490 catalyzes the generation of labda-8(17),13-dienyl diphosphate by the release of a proton at H-7 in the C8-carbonium ion of (+)-copalyl diphosphate
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LADIS_STRCL
545
0
58120
Swiss-Prot
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expressed in Escherichia coli
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expression in Escherichia coli
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Yamada, Y.; Komatsu, M.; Ikeda, H.
Chemical diversity of labdane-type bicyclic diterpene biosynthesis in Actinomycetales microorganisms
J. Antibiot.
69
515-523
2016
Streptomyces clavuligerus (D5SJ87), Streptomyces clavuligerus, Streptomyces clavuligerus ATCC 27064 (D5SJ87)
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Lemke, C.; Roach, K.; Ortega, T.; Tantillo, D.J.; Siegel, J.B.; Peters, R.J.
Investigation of acid-base catalysis in halimadienyl diphosphate synthase involved in Mycobacterium tuberculosis virulence
ACS Bio Med Chem Au
2
490-498
2022
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
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