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Information on EC 5.5.1.23 - aklanonic acid methyl ester cyclase and Organism(s) Streptomyces galilaeus and UniProt Accession O52646

for references in articles please use BRENDA:EC5.5.1.23
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EC Tree
IUBMB Comments
The enzyme is involved in the biosynthesis of aklaviketone, an intermediate in the biosynthetic pathways leading to formation of several anthracycline antibiotics, including aclacinomycin, daunorubicin and doxorubicin.
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This record set is specific for:
Streptomyces galilaeus
UNIPROT: O52646
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Word Map
  • 5.5.1.23
  • desaturase
  • arachidonic
  • delta6-desaturase
  • polyunsaturated
  • delta5
  • alpha-linolenic
  • b5-like
  • histidine-rich
  • di-homo-gamma-linolenic
  • daunomycin
  • desaturation
  • alpina
  • oleic
  • delta5-desaturation
  • polyketide
  • mortierella
The taxonomic range for the selected organisms is: Streptomyces galilaeus
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
aklanonic acid methyl ester cyclase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SYSTEMATIC NAME
IUBMB Comments
aklaviketone lyase (decyclizing)
The enzyme is involved in the biosynthesis of aklaviketone, an intermediate in the biosynthetic pathways leading to formation of several anthracycline antibiotics, including aclacinomycin, daunorubicin and doxorubicin.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
methyl aklanonate
aklaviketone
show the reaction diagram
-
enzyme is responsible for closing the last ring of the aclacinomycin aglycone moiety
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
methyl aklanonate
aklaviketone
show the reaction diagram
-
enzyme is responsible for closing the last ring of the aclacinomycin aglycone moiety
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
enzyme is part of the akn gene cluster needed for aklavinone biosynthesis. It is responsible for closing the last ring of the aclacinomycin aglycone moiety
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DNRD_STRGJ
144
0
16731
Swiss-Prot
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rty, K.; Kantola, J.; Hautala, A.; Hakala, J.; Ylihonko, K.; Mntsl, P.
Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster
Gene
293
115-122
2002
Streptomyces galilaeus (O52646), Streptomyces galilaeus, Streptomyces galilaeus ATCC 31615 (O52646)
Manually annotated by BRENDA team