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Information on EC 5.5.1.18 - lycopene epsilon-cyclase and Organism(s) Arabidopsis thaliana and UniProt Accession Q38932

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EC Tree
IUBMB Comments
The carotenoid lycopene has the psi-end group at both ends. When acting on one end, this enzyme forms delta-carotene. When acting on both ends, it forms epsilon-carotene.
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This record set is specific for:
Arabidopsis thaliana
UNIPROT: Q38932
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Word Map
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
lycopene epsilon cyclase, lycopene epsilon-cyclase, lcy-e, crtl-e, oslcye, epsilon lycopene cyclase, epsilon-lcy, lycopene-epsilon-cyclase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
epsilon lycopene cyclase
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CrtL-e
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-
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-
LCYe
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-
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-
SYSTEMATIC NAME
IUBMB Comments
carotenoid psi-end group lyase (decyclizing)
The carotenoid lycopene has the psi-end group at both ends. When acting on one end, this enzyme forms delta-carotene. When acting on both ends, it forms epsilon-carotene.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
lycopene
delta-carotene
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
lycopene
delta-carotene
show the reaction diagram
the cyclization of lycopene (psi,psi-carotene) is a key branch point in the pathway of carotenoid biosynthesis
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-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
the cyclization of lycopene (psi,psi-carotene) is a key branch point in the pathway of carotenoid biosynthesis
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
LCYE_ARATH
524
1
58491
Swiss-Prot
Chloroplast (Reliability: 4)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A447S
like the wild-type enzyme the mutant enzyme adds two epsilon-rings to lycopene, forming epsilon-carotene
L448H
the mutant adds two epsilon-ring to lycopene, forming epsilon-carotene
L448R
the mutant adds two epsilon-ring to lycopene, forming epsilon-carotene
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cunningham, F.X. Jr.; Pogson, B.; Sun, Z.; McDonald, K.A., DellaPenna, D.; Gantt, E.
Functional analysis of the beta and epsilon lycopene cyclase enzymes of Arabidopsis reveals a mechanism for control of cyclic carotenoid formation
Plant Cell
8
1613-1626
1996
Arabidopsis thaliana (Q38932)
Manually annotated by BRENDA team
Cunningham, F.X. Jr.; Gantt, E.
One ring or two? Determination of ring number in carotenoids by lycopene epsilon-cyclases
Proc. Natl. Acad. Sci. USA
98
2905-2910
2001
Arabidopsis thaliana (Q38932), Arabidopsis thaliana, Lactuca sativa (Q9AXK7), Lactuca sativa var. romaine (Q9AXK7)
Manually annotated by BRENDA team