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Information on EC 5.5.1.15 - terpentedienyl-diphosphate synthase

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EC Tree
IUBMB Comments
Requires Mg2+. Contains a DXDD motif, which is a characteristic of diterpene cylases whose reactions are initiated by protonation at the 14,15-double bond of geranylgeranyl diphosphate (GGDP) . The triggering proton is lost at the end of the cyclization reaction . The product of the reaction, terpentedienyl diphosphate, is the substrate for EC 4.2.3.36, terpentetriene synthase and is a precursor of the diterpenoid antibiotic terpentecin.
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The enzyme appears in viruses and cellular organisms
Synonyms
Cyc1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
geranylgeranyl diphosphate = terpentedienyl diphosphate
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