Reference on EC 5.5.1.12 - copalyl diphosphate synthase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
LeFever, R.E.; Vogel, B.S.; Croteau, R.
Diterpenoid resin acid biosynthesis in conifers: enzymic cyclization of geranylgeranyl pyrophosphate to abietadiene, the precursor of abietic acid
Arch. Biochem. Biophys.
313
139-149
1994
Abies grandis, Pinus contorta
Ravn, M.M.; Coates, R.M.; Jetter, R.; Croteau, R.B.
Stereospecific intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to (-)-abietadiene catalyzed by recombinant cyclase from grand fir (Abies grandis)
Chem. Commun. (Camb.)
1998
21-22
1998
Abies grandis, Pinus contorta
-
Ravn, M.M.; Coates, R.M.; Flory, J.E.; Peters, R.J.; Croteau, R.
Stereochemistry of the cyclization-rearrangement of (+)-copalyl diphosphate to (-)-abietadiene catalyzed by recombinant abietadiene synthase from Abies grandis
Org. Lett.
2
573-576
2000
Abies grandis
Peters, R.J.; Flory, J.E.; Jetter, R.; Ravn, M.M.; Lee, H.J.; Coates, R.M.; Croteau, R.B.
Abietadiene synthase from grand fir (Abies grandis): characterization and mechanism of action of the "pseudomature" recombinant enzyme
Biochemistry
39
15592-15602
2000
Abies grandis
Peters, R.J.; Ravn, M.M.; Coates, R.M.; Croteau, R.B.
Bifunctional abietadiene synthase: Free diffusive transfer of the (+)-copalyl diphosphate intermediate between two distinct active sites
J. Am. Chem. Soc.
123
8974-8978
2001
Abies grandis
Peters, R.J.; Croteau, R.B.
Abietadiene synthase catalysis: conserved residues involved in protonation-initiated cyclization of geranylgeranyl diphosphate to (+)-copalyl diphosphate
Biochemistry
41
1836-1842
2002
Abies grandis
Peters, R.J.; Croteau, R.B.
Abietadiene synthase catalysis: mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement
Proc. Natl. Acad. Sci. USA
99
580-584
2002
Abies grandis
Ravn, M.M.; Peters, R.J.; Coates, R.M.; Croteau, R.
Mechanism of abietadiene synthase catalysis: stereochemistry and stabilization of the cryptic pimarenyl carbocation intermediates
J. Am. Chem. Soc.
124
6998-7006
2002
Abies grandis
Peters, R.J.; Carter, O.A.; Zhang, Y.; Matthews, B.W.; Croteau, R.B.
Bifunctional abietadiene synthase: mutual structural dependence of the active sites for protonation-initiated and ionization-initiated cyclizations
Biochemistry
42
2700-2707
2003
Abies grandis
Smith, M.W.; Yamaguchi, S.; Ait-Ali, T.; Kamiya, Y.
The first step of gibberellin biosynthesis in pumpkin is catalyzed by at least two copalyl diphosphate synthases encoded by differentially regulated genes
Plant Physiol.
118
1411-1419
1998
Cucurbita maxima
Tudzynski, B.; Kawaide, H.; Kamiya, Y.
Gibberellin biosynthesis in Gibberella fujikuroi: cloning and characterization of the copalyl diphosphate synthase gene
Curr. Genet.
34
234-240
1998
Fusarium fujikuroi
Zhou, K.; Peters, R.J.
Investigating the conservation pattern of a putative second terpene synthase divalent metal binding motif in plants
Phytochemistry
70
366-369
2009
Abies grandis
Sugai, Y.; Ueno, Y.; Hayashi, K.; Oogami, S.; Toyomasu, T.; Matsumoto, S.; Natsume, M.; Nozaki, H.; Kawaide, H.
Enzymatic (13)C labeling and multidimensional NMR analysis of miltiradiene synthesized by bifunctional diterpene cyclase in Selaginella moellendorffii
J. Biol. Chem.
286
42840-42847
2011
Selaginella moellendorffii (G9MAN7), Selaginella moellendorffii
Zerbe, P.; Chiang, A.; Yuen, M.; Hamberger, B.; Hamberger, B.; Draper, J.A.; Britton, R.; Bohlmann, J.
Bifunctional cis-abienol synthase from Abies balsamea discovered by transcriptome sequencing and its implications for diterpenoid fragrance production
J. Biol. Chem.
287
12121-12131
2012
Abies balsamea (H8ZM71)
Hall, D.; Zerbe, P.; Jancsik, S.; Quesada, A.; Dullat, H.; Madilao, L.; Yuen, M.; Bohlmann, J.
Evolution of conifer diterpene synthases: diterpene resin acid biosynthesis in lodgepole pine and jack pine involves monofunctional and bifunctional diterpene synthases
Plant Physiol.
161
600-616
2013
Pinus banksiana (M4HXU6), Pinus contorta (M4HXW7)
Brueckner, K.; Bozic, D.; Manzano, D.; Papaefthimiou, D.; Pateraki, I.; Scheler, U.; Ferrer, A.; de Vos, R.C.; Kanellis, A.K.; Tissier, A.
Characterization of two genes for the biosynthesis of abietane-type diterpenes in rosemary (Rosmarinus officinalis) glandular trichomes
Phytochemistry
101
52-64
2014
Salvia rosmarinus (W8QQT6), Salvia rosmarinus
Zerbe, P.; Chiang, A.; Dullat, H.; ONeil-Johnson, M.; Starks, C.; Hamberger, B.; Bohlmann, J.
Diterpene synthases of the biosynthetic system of medicinally active diterpenoids in Marrubium vulgare
Plant J.
79
914-927
2014
Marrubium vulgare (A0A075FA51), Marrubium vulgare
Cui, G.; Duan, L.; Jin, B.; Qian, J.; Xue, Z.; Shen, G.; Snyder, J.H.; Song, J.; Chen, S.; Huang, L.; Peters, R.J.; Qi, X.
Functional divergence of diterpene syntheses in the medicinal plant Salvia miltiorrhiza
Plant Physiol.
169
1607-1618
2015
Salvia miltiorrhiza f. alba (A0A0A7AN31), Salvia miltiorrhiza f. alba (A0A0A7ANT1), Salvia miltiorrhiza f. alba bh2-7 (A0A0A7AN31), Salvia miltiorrhiza f. alba bh2-7 (A0A0A7ANT1)
Schulte, S.; Potter, K.C.; Lemke, C.; Peters, R.J.
Catalytic bases and stereocontrol in Lamiaceae class II diterpene cyclases
Biochemistry
57
3473-3479
2018
Salvia miltiorrhiza (B8PQ84), Salvia miltiorrhiza
Li, Q.; Di, P.; Lu, W.; Zhang, L.; Chen, W.
Bioinformatics analysis of copalyl diphosphate synthase in Salviae Miltiorrhizae Radix et Rhizoma
Chin. Tradit. Herbal Drugs
46
887-894
2015
Salvia miltiorrhiza
-
Gnanasekaran, T.; Vavitsas, K.; Andersen-Ranberg, J.; Nielsen, A.Z.; Olsen, C.E.; Hamberger, B.; Jensen, P.E.
Heterologous expression of the isopimaric acid pathway in Nicotiana benthamiana and the effect of N-terminal modifications of the involved cytochrome P450 enzyme
J. Biol. Eng.
9
24
2015
Picea abies (Q675L5)
Ignea, C.; Trikka, F.; Nikolaidis, A.; Georgantea, P.; Ioannou, E.; Loupassaki, S.; Kefalas, P.; Kanellis, A.; Roussis, V.; Makris, A.; Kampranis, S.
Efficient diterpene production in yeast by engineering Erg20p into a geranylgeranyl diphosphate synthase
Metab. Eng.
27
65-75
2015
Picea abies (Q675L4)
-
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