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Information on EC 5.4.99.7 - Lanosterol synthase and Organism(s) Arabidopsis thaliana and UniProt Accession Q1G1A4

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EC Tree
     5 Isomerases
         5.4 Intramolecular transferases
             5.4.99 Transferring other groups
                5.4.99.7 Lanosterol synthase
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This record set is specific for:
Arabidopsis thaliana
UNIPROT: Q1G1A4 not found.
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Word Map
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
atlas, oxidosqualene cyclase, lanosterol synthase, 2,3-oxidosqualene cyclase, erg7p, oxidosqualene-lanosterol cyclase, 2,3-oxidosqualene-lanosterol cyclase, 2,3-oxidosqualene:lanosterol cyclase, oxidosqualene:lanosterol cyclase, squalene 2,3-oxide-lanosterol cyclase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2,3-Epoxysqualene lanosterol-cyclase
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2,3-epoxysqualene--lanosterol cyclase
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-
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2,3-Epoxysqualene-lanosterol cyclase
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2,3-Oxidosqualene cyclase
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2,3-Oxidosqualene sterol cyclase
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2,3-Oxidosqualene-lanosterol cyclase
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Cyclase, 2,3-oxidosqualene-lanosterol
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Lanosterol 2,3-oxidosqualene cyclase
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OSC
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Oxidosqualene cyclase
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Oxidosqualene--lanosterol cyclase
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Oxidosqualene-lanosterol cyclase
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Squalene 2,3-epoxide:lanosterol cyclase
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Squalene 2,3-oxide-lanosterol cyclase
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Squalene epoxidase-cyclase
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Squalene-2,3-oxide-lanosterol cyclase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
cyclization
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isomerization
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SYSTEMATIC NAME
IUBMB Comments
(S)-2,3-Epoxysqualene mutase (cyclizing, lanosterol-forming)
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CAS REGISTRY NUMBER
COMMENTARY hide
9032-71-7
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(3S)-2,3-epoxy-2,3-dihydrosqualene
lanosterol
show the reaction diagram
-
-
-
r
(3S)-2,3-oxidosqualene
lanosterol
show the reaction diagram
-
-
-
-
?
(S)-2,3-oxidosqualene
lanosterol
show the reaction diagram
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-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(3S)-2,3-epoxy-2,3-dihydrosqualene
lanosterol
show the reaction diagram
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-
-
r
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
jasmonate
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LAS1 gene expression is induced by the application of jasmonate
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
weak expression
Manually annotated by BRENDA team
weak expression
Manually annotated by BRENDA team
weak expression
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
the enzyme belongs to the product-specific oxidosqualene cyclases (OSCs) that constitute a significant metabolic branch point which is the initial step of triterpene chemical diversity
metabolism
the enzyme as product-specific oxidosqualene cyclase constitutes a significant metabolic branch point which is the initial step of triterpene chemical diversity
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
LAS1_ARATH
756
0
86518
Swiss-Prot
other Location (Reliability: 2)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
no visible morphological phenotypes are observed in enzyme disruption mutant and no differences in sterol profiles between the wild type and mutant are detected. Enzyme gene complements enzyme-deficient yeast strain
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Saccharomyces cerevisiae
gene LAS1, recombinant expression in Solanum tuberosum leaves using the transformation method with Agrobacterium tumefaciens strain EHA 105. Overexpression of the Arabidopsis LAS in transgenic potato modifies phytosterol and steroidal glycoalkaloid metabolite levels and the transcript levels of the respective biosynthetic genes. LAS1 pverexpression in Solanum tnerosum leaves results in increased steroidal glycoalkaloid level and reduced phytosterol level in the leaves, while the steroidal glycoalkaloid level in the tuber flesh is reduced
expression in Saccharomyces cerevisiae
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kolesnikova, M.D.; Xiong, Q.; Lodeiro, S.; Hua, L.; Matsuda, S.P.
Lanosterol biosynthesis in plants
Arch. Biochem. Biophys.
447
87-95
2006
Arabidopsis thaliana
Manually annotated by BRENDA team
Suzuki, M.; Xiang, T.; Ohyama, K.; Seki, H.; Saito, K.; Muranaka, T.; Hayashi, H.; Katsube, Y.; Kushiro, T.; Shibuya, M.; Ebizuka, Y.
Lanosterol synthase in dicotyledonous plants
Plant Cell Physiol.
47
565-571
2006
Arabidopsis thaliana (Q1G1A4)
Manually annotated by BRENDA team
Ohyama, K.; Suzuki, M.; Kikuchi, J.; Saito, K.; Muranaka, T.
Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis
Proc. Natl. Acad. Sci. USA
106
725-730
2009
Arabidopsis thaliana
Manually annotated by BRENDA team
Kumar, A.; Fogelman, E.; Weissberg, M.; Tanami, Z.; Veilleux, R.E.; Ginzberg, I.
Lanosterol synthase-like is involved with differential accumulation of steroidal glycoalkaloids in potato
Planta
246
1189-1202
2017
Solanum tuberosum (A0A1B0YWV6), Solanum tuberosum, Arabidopsis thaliana (Q1G1A4)
Manually annotated by BRENDA team