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Information on EC 5.4.99.65 - pre-alpha-onocerin synthase

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EC Tree

5 Isomerases

5.4 Intramolecular transferases

5.4.99 Transferring other groups

5.4.99.65 pre-alpha-onocerin synthase

IUBMB Comments

Isolated from the plant Lycopodium clavatum. The enzyme does not act on (3S)-2,3-epoxy-2,3-dihydrosqualene and does not form any alpha-onocerin.

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The expected taxonomic range for this enzyme is: Lycopodium clavatum

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(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene

pre-alpha-onocerin

Synonyms

Lcc,

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Lcc

Lcc

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene = pre-alpha-onocerin

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SYSTEMATIC NAME

IUBMB Comments

(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene mutase (cyclizing, pre-alpha-onocerin-forming)

Isolated from the plant Lycopodium clavatum. The enzyme does not act on (3S)-2,3-epoxy-2,3-dihydrosqualene and does not form any alpha-onocerin.

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene

pre-alpha-onocerin

Lycopodium clavatum

743390

2,3,22,23-dioxidosqualene

pre-alpha-onocerin

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

(3S,22S)-2,3:22,23-diepoxy-2,3,22,23-tetrahydrosqualene

pre-alpha-onocerin

Lycopodium clavatum

743390

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Lycopodium clavatum

742284, 743390

A0A125SXN1

UniProt

brenda

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

metabolism

Lycopodium clavatum

ferns are known to produce onoceroids including onoceranes and serratanes having unusual structures among triterpenes. Serratanes are directly biosynthesized from pre-alpha-onocerin, synthesized by pre-alpha-onocerin synthase, and not from alpha-onocerin, synthesized by alpha-onocerin synthase, EC 5.4.99.66, from pre-alpha-onocerin

743390

physiological function

2 entries

physiological function

Lycopodium clavatum

both dioxidosqualene cyclase LCC and dioxidosqualene cyclase LCD are required to produce alpha-onocerin

742284

physiological function

Lycopodium clavatum

743390

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UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]

SOURCE

Sequence

A0A125SXN1 pBLAST

LCC_LYCCL

Lycopodium clavatum

756

86189

Swiss-Prot

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

additional information

Lycopodium clavatum

while the heterologous LCC gene expression produces the bicyclic triterpene pre-alpha-onocerin, a combination of LCC and alpha-onocerin synthase LCD produces onoceranes, and that of LCC and tohogenol synthase LCE produces serratanes

743390

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CLONED/commentary

ORGANISM

UNIPROT

LITERATURE

expression in Saccharomyces cerevisiae

Lycopodium clavatum

742284

functional recombinant enzyme expression in Saccharomyces cerevisiae strain GIL77, coexpression with alpha-onocerin synthase leading to the production of tohogenol and serratenediol, NMR metabolite identification, overview

Lycopodium clavatum

743390

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