Information on EC 5.4.99.46 - shionone synthase

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EC Tree 5 Isomerases 5.4 Intramolecular transferases 5.4.99 Transferring other groups 5.4.99.46 shionone synthase

IUBMB Comments

The enzyme gives traces of four other triterpenoids

The expected taxonomic range for this enzyme is: Aster tataricus

Reaction Schemes

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(3S)-2,3-epoxy-2,3-dihydrosqualene

shionone

Synonyms
shionone synthase, more

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

OSC

Aster tataricus

715030

Oxidosqualene cyclase

shionone synthase

SHS

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

(3S)-2,3-epoxy-2,3-dihydrosqualene = shionone

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SYSTEMATIC NAME

IUBMB Comments

(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, shionone-forming)

The enzyme gives traces of four other triterpenoids

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

Reversibility
r=reversible
ir=irreversible
?=not specified

(3S)-2,3-epoxy-2,3-dihydrosqualene

shionone + beta-amyrin + friedelin + dammara-20,24-dienol + 4-epishionone

Aster tataricus

715030

Substrates: -
Products: the ratio of the products is roughly estimated as shionone:beta-amyrin:friedelin:dammara-20,24-dienol:4-epishionone = 90%:2%:2%:1.5%:1.5%

oxidosqualene

shionone

Aster tataricus

715030

Substrates: -
Products: the cyclase yields ca. 90% shionone and small amounts of beta-amyrin, friedelin, dammara-20,24-dienol, and 4-epishionone

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only manually annotated data include textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks include all textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks + FRENDAco-occurrence of enzyme names and organism names (less precise)

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Aster tataricus

715030

brenda

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only manually annotated data include textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks

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SOURCE TISSUE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

SOURCE

brenda

brenda

brenda

brenda

high expression

brenda

brenda

high expression

brenda

brenda

high expression

brenda

brenda

Highest Expressing Human Cell Lines

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Cell Line Links

Gene Links

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UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]

SOURCE

SEQUENCE

LOCALIZATION PREDICTION

The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).

F8WQD0 pBLAST

SHS1_ASTTA

Aster tataricus

761

87565

Swiss-Prot

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

expressed in lanosterol synthase-deficient yeast

Aster tataricus

715030

expressed in Saccharomyces cerevisiae strain GIL77 (lanosterol synthase-deficient strain)

Aster tataricus

715030

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

715030

Sawai, S.; Uchiyama, H.; Mizuno, S.; Aoki, T.; Akashi, T.; Ayabe, S.; Takahashi, T.

Molecular characterization of an oxidosqualene cyclase that yields shionone, a unique tetracyclic triterpene ketone of Aster tataricus

FEBS Lett.

585

1031-1036

2011

Aster tataricus

21377465

brenda

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EXTERNAL LINKS (specific for EC-Number 5.4.99.46)

ExplorEnz (official portal for IUBMB Enzyme Nomenclature)

Expasy Enzyme Nomenclature Database

KEGG

SABIO-RK

NCBI: PubMed, Protein, Nucleotide, Structure, Gene, OMIM

Enzyme Nomenclature (alternative site)

UniProt

PDB

PROSITE Database of protein families and domains

InterPro (database of protein families, domains and functional sites)

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