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Information on EC 5.4.99.40 - alpha-amyrin synthase and Organism(s) Pisum sativum and UniProt Accession Q9LRH7

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EC Tree
     5 Isomerases
         5.4 Intramolecular transferases
             5.4.99 Transferring other groups
                5.4.99.40 alpha-amyrin synthase
IUBMB Comments
A multifunctional enzyme which produces both alpha- and beta-amyrin (see EC 5.4.99.39, beta-amyrin synthase).
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This record set is specific for:
Pisum sativum
UNIPROT: Q9LRH7
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Word Map
The taxonomic range for the selected organisms is: Pisum sativum
The enzyme appears in selected viruses and cellular organisms
Synonyms
oxidosqualene cyclases, mixed amyrin synthase, bmosc, obas2, mdosc3, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2,3-oxidosqualene alpha-amyrin cyclase
-
mixed amyrin synthase
a multifunctional enzyme which produces both alpha- and beta-amyrin (see EC 5.4.99.39, beta-amyrin synthase)
PATHWAY SOURCE
PATHWAYS
-
-, -, -
SYSTEMATIC NAME
IUBMB Comments
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, alpha-amyrin-forming)
A multifunctional enzyme which produces both alpha- and beta-amyrin (see EC 5.4.99.39, beta-amyrin synthase).
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(3S)-2,3-epoxy-2,3-dihydrosqualene
alpha-amyrin
show the reaction diagram
PSM produces both alpha- and beta-amyrin in about 3 : 2 ratio together with at least six other minor triterpenes
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(3S)-2,3-epoxy-2,3-dihydrosqualene
alpha-amyrin
show the reaction diagram
PSM produces both alpha- and beta-amyrin in about 3 : 2 ratio together with at least six other minor triterpenes
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ABAMS_PEA
764
0
88277
Swiss-Prot
other Location (Reliability: 2)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression of PSM in ERG7 deficient yeast mutant GIL77
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Morita, M.; Shibuya, M.; Kushiro, T.; Masuda, K.; Ebizuka, Y.
Molecular cloning and functional expression of triterpene synthases from pea (Pisum sativum) new alpha-amyrin-producing enzyme is a multifunctional triterpene synthase
Eur. J. Biochem.
267
3453-3460
2000
Pisum sativum (Q9LRH7), Pisum sativum
Manually annotated by BRENDA team