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Information on EC 5.4.99.39 - beta-amyrin synthase and Organism(s) Glycyrrhiza glabra and UniProt Accession Q9MB42

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EC Tree
     5 Isomerases
         5.4 Intramolecular transferases
             5.4.99 Transferring other groups
                5.4.99.39 beta-amyrin synthase
IUBMB Comments
Some organism possess a monofunctional beta-amyrin synthase [3,4,6-11], other have a multifunctional enzyme that also catalyses the synthesis of alpha-amyrin (EC 5.4.99.40) or lupeol (EC 5.4.99.41) .
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This record set is specific for:
Glycyrrhiza glabra
UNIPROT: Q9MB42
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Word Map
The taxonomic range for the selected organisms is: Glycyrrhiza glabra
The enzyme appears in selected viruses and cellular organisms
Synonyms
beta-amyrin synthase, beta-as, mdosc1, gsas1, gsas2, esbas, cbbas, multifunctional osc, beta-amyrin cyclase, obas1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SYSTEMATIC NAME
IUBMB Comments
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, beta-amyrin-forming)
Some organism possess a monofunctional beta-amyrin synthase [3,4,6-11], other have a multifunctional enzyme that also catalyses the synthesis of alpha-amyrin (EC 5.4.99.40) [5] or lupeol (EC 5.4.99.41) [6].
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-2,3-oxidosqualene
beta-amyrin
show the reaction diagram
-
-
-
?
2,3-oxidosqualene
beta-amyrin
show the reaction diagram
-
-
sole product
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
BAMS_GLYGL
765
0
87516
Swiss-Prot
other Location (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
87500
-
x * 87500, calculated
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
-
x * 87500, calculated
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
functional expression in Saccharomyces cerevisiae mutant lacking lanosterol synthase activity results in production of beta-amyrin
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in Saccharomyces cerevisiae
-
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
after 24 h of elicitation, beta-amyrin synthase transcripts are increased at 0.1, 1, and 2 mM of methyl jasmonate, and they are increased at 0.1 and 1 mM salicylic acid
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hayashi, H.; Huang, P.; Kirakosyan, A.; Inoue, K.; Hiraoka, N.; Ikeshiro, Y.; Kushiro, T.; Shibuya, M.; Ebizuka, Y.
Cloning and characterization of a cDNA encoding beta-amyrin synthase involved in glycyrrhizin and soyasaponin biosyntheses in licorice
Biol. Pharm. Bull.
24
912-916
2001
Glycyrrhiza glabra
Manually annotated by BRENDA team
Shabani, L.; Ehsanpour, A.; Esmaeili, A.
Assessment of squalene synthase and beta-amyrin synthase gene expression in licorice roots treated with methyl jasmonate and salicylic acid using real-time qPCR
Russ. J. Plant Physiol.
57
480-484
2010
Glycyrrhiza glabra (Q9MB42)
-
Manually annotated by BRENDA team