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Information on EC 5.4.99.31 - thalianol synthase and Organism(s) Arabidopsis thaliana and UniProt Accession Q9FI37

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EC Tree
     5 Isomerases
         5.4 Intramolecular transferases
             5.4.99 Transferring other groups
                5.4.99.31 thalianol synthase
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This record set is specific for:
Arabidopsis thaliana
UNIPROT: Q9FI37 not found.
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The taxonomic range for the selected organisms is: Arabidopsis thaliana
The expected taxonomic range for this enzyme is: Arabidopsis thaliana
Synonyms
thas1, thalianol synthase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
At5g48010
locus name
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
cyclization
-
-
SYSTEMATIC NAME
IUBMB Comments
(S)-2,3-epoxysqualene mutase (cyclizing, thalianol-forming)
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(3S)-2,3-epoxy-2,3-dihydrosqualene
thalianol
show the reaction diagram
-
-
-
?
(3S,22S)-2(3),-22(23)-bis-oxidosqualene
(3S,13S,14R,21S)-21(22)-epoxy-malabarica-8,17-dien-3-ol
show the reaction diagram
-
-
-
-
?
(S)-squalene-2,3-epoxide
(3S,13S,14R)-malabarica-8,17,21-trien-3-ol
show the reaction diagram
-
-
i.e. thalianol
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(3S)-2,3-epoxy-2,3-dihydrosqualene
thalianol
show the reaction diagram
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PEN4_ARATH
766
0
88203
Swiss-Prot
other Location (Reliability: 5)
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene THAS1, recombinant expression in Rhodobacter capsulatus strain SB1003. and Synechocystis sp. PCC 6803 using promoters Pnif and PcoaT, coexpression with CAS1, LUP1, and MRN1. Subcloning in Saccharomyces cerevisiae strain GIL77. Isolation of triterpenes, while cycloartenol and lupeol represent typical plant triterpenes with tetracyclic plant sterol and pentacyclic plant triterpene scaffolds, respectively, thalianol and marneral exhibit more unusual tri- and monocyclic structures
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
THAS1 expression is induced by gravity and light
-
the Ca2+-dependent lipid-binding protein is a transcriptional repressor of THAS1
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Fazio, G.C.; Xu, R.; Matsuda, S.P.
Genome mining to identify new plant triterpenoids
J. Am. Chem. Soc.
126
5678-5679
2004
Arabidopsis thaliana
Manually annotated by BRENDA team
de Silva, K.; Laska, B.; Brown, C.; Sederoff, H.W.; Khodakovskaya, M.
Arabidopsis thaliana calcium-dependent lipid-binding protein (AtCLB): a novel repressor of abiotic stress response
J. Exp. Bot.
62
2679-2689
2011
Arabidopsis thaliana
Manually annotated by BRENDA team
Loeschcke, A.; Dienst, D.; Wewer, V.; Hage-Huelsmann, J.; Dietsch, M.; Kranz-Finger, S.; Hueren, V.; Metzger, S.; Urlacher, V.B.; Gigolashvili, T.; Kopriva, S.; Axmann, I.M.; Drepper, T.; Jaeger, K.E.
The photosynthetic bacteria Rhodobacter capsulatus and Synechocystis sp. PCC 6803 as new hosts for cyclic plant triterpene biosynthesis
PLoS ONE
12
e0189816
2017
Arabidopsis thaliana (Q9FI37), Arabidopsis thaliana
Manually annotated by BRENDA team