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Disease on EC 5.4.99.16 - maltose alpha-D-glucosyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Arteritis
Arterivirus nsp12 versus the coronavirus nsp16 2'-O-methyltransferase: comparison of the C-terminal cleavage products of two nidovirus pp1ab polyproteins.
Atherosclerosis
DNA hypomethylation and methyltransferase expression in atherosclerotic lesions.
Brain Injuries
DNA methyltransferase contributes to delayed ischemic brain injury.
Brain Ischemia
DNA methyltransferase contributes to delayed ischemic brain injury.
Carcinogenesis
Inhibition of DNA cytosine methyltransferase by chemopreventive selenium compounds, determined by an improved assay for DNA cytosine methyltransferase and DNA cytosine methylation.
Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation.
Carcinoma
Inhibition of DNA cytosine methyltransferase by chemopreventive selenium compounds, determined by an improved assay for DNA cytosine methyltransferase and DNA cytosine methylation.
Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation.
Colonic Neoplasms
Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis.
Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation.
Mechanisms for the involvement of DNA methylation in colon carcinogenesis.
Colorectal Neoplasms
Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation.
COVID-19
In-Silico Drug Designing of Spike Receptor with Its ACE2 Receptor and Nsp10/Nsp16 MTase Complex Against SARS-CoV-2.
Decompression Sickness
Angle and locus of the bend induced by the msp I DNA methyltransferase in a sequence-specific complex with DNA.
Dehydration
Rice cytosine DNA methyltransferases - gene expression profiling during reproductive development and abiotic stress.
Dengue
A structural view of the RNA-dependent RNA polymerases from the Flavivirus genus.
An interaction between the methyltransferase and RNA dependent RNA polymerase domains of the West Nile virus NS5 protein.
Analysis of flavivirus NS5 methyltransferase cap binding.
Computational analysis of methyl transfer reactions in dengue virus methyltransferase.
Detection and quantification of flavivirus NS5 methyl-transferase activities.
Evaluating the suitability of RNA intervention mechanism exerted by some flavonoid molecules against dengue virus MTase RNA capping site: a molecular docking, molecular dynamics simulation, and binding free energy study.
Inhibitor designing, virtual screening, and docking studies for methyltransferase: A potential target against dengue virus.
Small molecule inhibitors that selectively block dengue virus methyltransferase.
Structure of the NS5 methyltransferase from Zika virus and implications in inhibitor design.
The dengue virus NS5 protein as a target for drug discovery.
Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay.
Encephalitis, Japanese
A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication.
A structural view of the RNA-dependent RNA polymerases from the Flavivirus genus.
Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5.
Glioma
DNA methyltransferase levels and altered CpG methylation in the total genome and in the GSTP1 gene in human glioma cells transfected with sense and antisense DNA methyltransferase cDNA.
Hematologic Neoplasms
Cost-effective screening of DNMT3A coding sequence identifies somatic mutation in pediatric T-cell acute lymphoblastic leukemia.
Hepatitis, Chronic
Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis.
Herpes Simplex
Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes.
Infarction, Middle Cerebral Artery
DNA methyltransferase contributes to delayed ischemic brain injury.
Infections
Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes.
Comparative studies of the phage T2 and T4 DNA (N6-adenine)methyltransferases: amino acid changes that affect catalytic activity.
In-Silico Drug Designing of Spike Receptor with Its ACE2 Receptor and Nsp10/Nsp16 MTase Complex Against SARS-CoV-2.
MTase Domain of Dendrolimus punctatus cypovirus VP3 Mediates Virion Attachment and Interacts with Host ALP Protein.
Leukemia, Erythroblastic, Acute
Baculovirus-mediated expression and characterization of the full-length murine DNA methyltransferase.
Leukemia, Myeloid, Acute
Functional Analysis of DNMT3A DNA Methyltransferase Mutations Reported in Patients with Acute Myeloid Leukemia.
Lyme Disease
DNA Methylation by Restriction Modification Systems Affects the Global Transcriptome Profile in Borrelia burgdorferi.
Neoplasms
Chemiluminescence resonance energy transfer biosensing platform for site-specific determination of DNA methylation and assay of DNA methyltransferase activity using exonuclease III-assisted target recycling amplification.
Cytosine-5 methylation-directed construction of a Au nanoparticle-based nanosensor for simultaneous detection of multiple DNA methyltransferases at the single-molecule level.
Detection of DNA methyltransferase activity using allosteric molecular beacons.
DNA hypomethylation and methyltransferase expression in atherosclerotic lesions.
Elevated expression and altered pattern of activity of DNA methyltransferase in liver tumors of rats fed methyl-deficient diets.
Expression of T:G mismatch-specific thymidine-DNA glycosylase and DNA methyl transferase genes during development and tumorigenesis.
Highly sensitive fluorescence assay of DNA methyltransferase activity by methylation-sensitive cleavage-based primer generation exponential isothermal amplification-induced G-quadruplex formation.
Inhibition of C5-cytosine-DNA-methyltransferases.
Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation.
Mechanisms for the involvement of DNA methylation in colon carcinogenesis.
Molecular mechanisms of adaptive response to alkylating agents in Escherichia coli and some remarks on O(6)-methylguanine DNA-methyltransferase in other organisms.
Sensitive detection of DNA methyltransferase using the dendritic rolling circle amplification-induced fluorescence.
Sensitive surface plasmon resonance detection of methyltransferase activity and screening of its inhibitors amplified by p53 protein bound to methylation-specific ds-DNA consensus sites.
Signal amplification of graphene oxide combining with restriction endonuclease for site-specific determination of DNA methylation and assay of methyltransferase activity.
Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily.
Ultrasensitive and Accurate Assay of Human Methyltransferase Activity at the Single-Cell Level Based on a Single Integrated Magnetic Microprobe.
Prostatic Neoplasms
Going beyond Polycomb: EZH2 functions in prostate cancer.
Rabies
Critical Role of K1685 and K1829 in the Large Protein of Rabies Virus in Viral Pathogenicity and Immune Evasion.
Starvation
Regulation of genes encoding subunits of the trehalose synthase complex in Saccharomyces cerevisiae: novel variations of STRE-mediated transcription control?
Stroke
DNA methyltransferase contributes to delayed ischemic brain injury.
Vaccinia
Coronavirus nonstructural protein 16 is a cap-0 binding enzyme possessing (nucleoside-2'O)-methyltransferase activity.
In silico identification, structure prediction and phylogenetic analysis of the 2'-O-ribose (cap 1) methyltransferase domain in the large structural protein of ssRNA negative-strand viruses.
Reassignment of specificities of two cap methyltransferase domains in the reovirus lambda 2 protein.
Yellow Fever
Analysis of flavivirus NS5 methyltransferase cap binding.
Aptamer Displacement Screen for Flaviviral RNA Methyltransferase Inhibitors.
Zika Virus Infection
Structure-based screening and validation of bioactive compounds as Zika virus methyltransferase (MTase) inhibitors through first-principle density functional theory, classical molecular simulation and QM/MM affinity estimation.