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IUBMB Comments The enzyme is activated by D -glucose, which probably acts as an acceptor for a phosphate residue from the substrate, thus being itself converted into the product. cf . EC 5.4.2.2 , phosphoglucomutase (α-D -glucose-1,6-bisphosphate-dependent).
Synonyms
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D-Glucose-1-phosphate:D-glucose-6-phosphotransferase
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EC 2.7.5.5
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formerly
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Glucose phosphomutase
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Glucose-1-phosphate phosphotransferase
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Phosphomutase, glucose (glucose-cofactor)
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alpha-D-glucose 1-phosphate = D-glucose 6-phosphate
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group transfer
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intermolecular, phosphate group
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alpha-D-glucose 1,6-phosphomutase (glucose-cofactor)
The enzyme is activated by D-glucose, which probably acts as an acceptor for a phosphate residue from the substrate, thus being itself converted into the product. cf. EC 5.4.2.2, phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent).
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2-Deoxy-D-glucose + alpha-D-glucose 1-phosphate
D-Glucose + 2-deoxy-D-glucose 6-phosphate
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Substrates: -
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3-O-Methyl-D-glucose + alpha-D-glucose 1-phosphate
3-O-Methyl-D-glucose 6-phosphate + D-glucose
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Substrates: -
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alpha-D-glucose 1-phosphate + alpha-D-glucose
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Substrates: -
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alpha-D-Glucose 1-phosphate + D-glucose
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alpha-D-Glucose 1-phosphate + D-glucose
D-Glucose + alpha-D-glucose 6-phosphate
alpha-Methyl-D-glucoside + alpha-D-glucose 1-phosphate
alpha-Methyl-D-glucoside 6-phosphate + D-glucose
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Substrates: -
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beta-Methyl-D-glucoside + alpha-D-glucose 1-phosphate
beta-Methyl-D-glucoside 6-phosphate + D-glucose
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Substrates: -
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D-Fructose + alpha-D-glucose 1-phosphate
D-Fructose 6-phosphate + D-glucose
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Substrates: -
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D-Galactose + alpha-D-glucose 1-phosphate
D-Galactose 6-phosphate + D-glucose
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Substrates: -
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D-Mannose + alpha-D-glucose 1-phosphate
D-Mannose 6-phosphate + D-glucose
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Substrates: -
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Fructose 1-phosphate + D-glucose
D-glucose 6-phosphate + fructose
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Substrates: -
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L-Sorbose + alpha-D-glucose 1-phosphate
L-Sorbose 6-phosphate + D-glucose
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Substrates: -
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additional information
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Substrates: no substrates are 6-deoxy-D-glucose, D-ribose, D-xylose, DL-serine, cytidine, adenosine, uridine, guanosine
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alpha-D-Glucose 1-phosphate + D-glucose
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Substrates: -
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alpha-D-Glucose 1-phosphate + D-glucose
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Substrates: -
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alpha-D-Glucose 1-phosphate + D-glucose
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Substrates: -
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alpha-D-Glucose 1-phosphate + D-glucose
D-Glucose + alpha-D-glucose 6-phosphate
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Substrates: -
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alpha-D-Glucose 1-phosphate + D-glucose
D-Glucose + alpha-D-glucose 6-phosphate
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Substrates: -
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alpha-D-Glucose 1-phosphate + D-glucose
D-Glucose + alpha-D-glucose 6-phosphate
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Substrates: -
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alpha-D-Glucose 1-phosphate + D-glucose
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alpha-D-Glucose 1-phosphate + D-glucose
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Substrates: -
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alpha-D-Glucose 1-phosphate + D-glucose
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Substrates: -
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alpha-D-Glucose 1-phosphate + D-glucose
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Substrates: -
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additional information
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no requirement for Mg2+, Mn2+, Fe2+
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additional information
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no inhibition by NaN3
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additional information
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no effect on the rate of reaction found for cysteine, glutathione, 2-mercaptoethanol, glucose 1,6-diphosphate, ribose 1,5-diphosphate
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0.9 - 1.1
alpha-D-glucose 1-phosphate
8.5
alpha-D-glucose
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assay coupled with glucose-6-phosphate dehydrogenase, following NADPH formation
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alpha-D-glucose
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direct assay with unreacted glucose 1-phosphate
0.9
alpha-D-glucose 1-phosphate
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direct assay with unreacted glucose 1-phosphate
1.1
alpha-D-glucose 1-phosphate
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assay coupled with glucose-6-phosphate dehydrogenase, following NADPH formation
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5
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direct assay with unreacted glucose 1-phosphate
6.5
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assay coupled with glucose-6-phosphate dehydrogenase, following NADPH formation
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Fujimoto, A.; Ingram, P.; Smith, R.A.
D-Glucose-1-phosphate:D-glucose-6-phosphotransferase
Biochim. Biophys. Acta
96
91-101
1965
Klebsiella aerogenes, Escherichia coli, Mycolicibacterium smegmatis
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