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Information on EC 5.4.2.2 - phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)
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5.4.2.2 phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)IUBMB Comments
Maximum activity is only obtained in the presence of alpha-D-glucose 1,6-bisphosphate. This bisphosphate is an intermediate in the reaction, being formed by transfer of a phosphate residue from the enzyme to the substrate, but the dissociation of bisphosphate from the enzyme complex is much slower than the overall isomerization. The enzyme also catalyses (more slowly) the interconversion of 1-phosphate and 6-phosphate isomers of many other alpha-D-hexoses, and the interconversion of alpha-D-ribose 1-phosphate and 5-phosphate. cf. EC 5.4.2.5, phosphoglucomutase (glucose-cofactor).
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Word Map
- 5.4.2.2
- hexokinase
- starch
- glycogen
- malate
- phosphorylase
- 6-phosphogluconate
- adenylate
- esterase
- 1-phosphate
-
pyrophosphorylase
- erythrocyte
- udp-glucose
- galactose
- glucose-1-phosphate
-
phosphofructokinase
- gpi
- transferrin
- aldolase
-
allozyme
- haptoglobin
-
glucosephosphate
-
malic
- entamoeba
-
zymodemes
-
hardy-weinberg
- histolytica
- phosphoglucoisomerase
- glucose-6-phosphatase
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monomorphic
- glyoxalase
- plastidial
-
starch-gel
-
phosphohexose
- fructokinase
- diptera
- galactose-1-phosphate
-
bloodstain
- udp-galactose
-
5.3.1.9
-
leloir
-
duffy
- phosphoenzyme
-
glycogenolysis
-
uridylyltransferase
- udp-glc
-
glc-6-p
- 1,6-diphosphate
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isoenzymatic
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2.7.1.1
- amyloplasts
- molecular biology
- food industry
- drug development
- medicine
The enzyme appears in viruses and cellular organisms
Synonyms
alpha phosphoglucomutase, alpha-Pgm, alpha-phosphoglucomutase, alpha-phosphoglucomutase 1, alpha-phosphoglucose mutase, cPGM, cytosolic phosphoglucomutase, EC 2.7.5.1, Glucose phosphomutase, PGM, 
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topREACTION 
REACTION DIAGRAM
COMMENTARY 
ORGANISM
UNIPROT
LITERATURE
alpha-D-glucose 1-phosphate = D-glucose 6-phosphate
in the forward reaction a phosphate from the enzyme is transferred to C-6 of glucose 1-phosphate which results in a dephosphoenzyme intermediate. In the second step phosphate from the C-1 of glucose is transferred to the enzyme for its regeneration. The reverse reaction proceeds via a similar mechanism
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alpha-D-glucose 1-phosphate = D-glucose 6-phosphate
ping-pong mechanism
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alpha-D-glucose 1-phosphate = D-glucose 6-phosphate
acid-base catalysis mechanism, key role for conformational change in its multistep reaction, which requires a dramatic 180 degree reorientation of the intermediate within the active site. Modeling shows that increased enzyme flexibility facilitates the reorientation of the reaction intermediate, coupling changes in structural dynamics with the unique catalytic mechanism of this enzyme
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alpha-D-glucose 1-phosphate = D-glucose 6-phosphate
acid-base catalysis mechanism, overview. His329 is appropriately positioned to abstract a proton from the O1/O6 hydroxyl of the phosphosugar substrates, and thus may serve as the general base in the reaction
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alpha-D-glucose 1-phosphate = D-glucose 6-phosphate
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PATHWAY SOURCE
PATHWAYS
KEGG
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Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, Biosynthesis of secondary metabolites, Galactose metabolism, Galactose metabolism, Galactose metabolism, Galactose metabolism, Galactose metabolism, Galactose metabolism, Galactose metabolism, Starch and sucrose metabolism, Starch and sucrose metabolism, Starch and sucrose metabolism, Starch and sucrose metabolism, Streptomycin biosynthesis, Streptomycin biosynthesis, Streptomycin biosynthesis, Streptomycin biosynthesis, Streptomycin biosynthesis