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IUBMB CommentsThe enzymes from vertebrates, platyhelminths, mollusks, annelids, crustaceans, insects, algae, some fungi and some bacteria (particularly Gram-negative) require 2,3-bisphospho-D-glycerate as a cofactor. The enzyme is activated by 2,3-bisphospho-D-glycerate by transferring a phosphate to histidine (His10 in man and Escherichia coli, His8 in Saccharomyces cerevisiae). This phosphate can be transferred to the free OH of 2-phospho-D-glycerate, followed by transfer of the phosphate already on the phosphoglycerate back to the histidine. cf. EC 5.4.2.12 phosphoglycerate mutase. The enzyme has no requirement for metal ions. This enzyme also catalyse, slowly, the reactions of EC 5.4.2.4 bisphosphoglycerate mutase.
Synonyms
phosphoglycerate mutase, pgam1, phosphoglycerate mutase 1, sts-1, pgam2, cofactor-dependent phosphoglycerate mutase, dpgm-b, bisphosphoglycerate phosphatase, 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase, rv3214,
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D-phosphoglycerate 2,3-phosphomutase (2,3-diphosphoglycerate-dependent)
The enzymes from vertebrates, platyhelminths, mollusks, annelids, crustaceans, insects, algae, some fungi and some bacteria (particularly Gram-negative) require 2,3-bisphospho-D-glycerate as a cofactor. The enzyme is activated by 2,3-bisphospho-D-glycerate by transferring a phosphate to histidine (His10 in man and Escherichia coli, His8 in Saccharomyces cerevisiae). This phosphate can be transferred to the free OH of 2-phospho-D-glycerate, followed by transfer of the phosphate already on the phosphoglycerate back to the histidine. cf. EC 5.4.2.12 phosphoglycerate mutase. The enzyme has no requirement for metal ions. This enzyme also catalyse, slowly, the reactions of EC 5.4.2.4 bisphosphoglycerate mutase.
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Rose, Z.B.
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Saccharomyces cerevisiae, Gallus gallus, Oryctolagus cuniculus, Homo sapiens, Sus scrofa
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Saccharomyces cerevisiae, Oryctolagus cuniculus
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Structure of a phosphoglycerate mutase:3-phosphoglyceric acid complex at 1.7 A
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Saccharomyces cerevisiae (P00950), Saccharomyces cerevisiae
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Saccharomyces cerevisiae, Schizosaccharomyces pombe
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Saccharomyces cerevisiae (P00950), Saccharomyces cerevisiae
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1999
Schizosaccharomyces pombe, Saccharomyces cerevisiae (P00950), Saccharomyces cerevisiae
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Hakobyan, D.; Nazaryan, K.
Investigation of interaction between enolase and phosphoglycerate mutase using molecular dynamics simulation
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23
625-633
2006
Saccharomyces cerevisiae
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