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Information on EC 5.3.99.2 - Prostaglandin-D synthase and Organism(s) Gallus gallus and UniProt Accession O73888

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EC Tree
     5 Isomerases
         5.3 Intramolecular oxidoreductases
             5.3.99 Other intramolecular oxidoreductases
                5.3.99.2 Prostaglandin-D synthase
IUBMB Comments
Brings about the opening of the epidioxy bridge. Some enzymes require glutathione.
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This record set is specific for:
Gallus gallus
UNIPROT: O73888
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Word Map
The taxonomic range for the selected organisms is: Gallus gallus
The enzyme appears in selected viruses and cellular organisms
Synonyms
l-pgds, prostaglandin synthase, beta-trace protein, ptgds, h-pgds, pgd synthase, prostaglandin d synthase, hpgds, lipocalin-type prostaglandin d synthase, prostaglandin d2 synthase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
glutathione dependent prostaglandine D2 synthase
i.e. PGDS
beta-Trace
-
-
-
-
Beta-trace protein
-
-
-
-
Glutathione-dependent PGD synthetase
-
-
-
-
Glutathione-independent PGD synthetase
-
-
-
-
H-PGDS
-
-
-
-
Hematopoietic prostaglandin D synthase
-
-
-
-
Isomerase, prostaglanin R2 D-
-
-
-
-
PGD synthase
-
-
-
-
PGD2 synthase
-
-
-
-
PGDS
-
-
-
-
PGDS2
-
-
-
-
PGH-PGD isomerase
-
-
-
-
Prostaglandin D synthase
-
-
-
-
Prostaglandin D2 synthase
-
-
-
-
Prostaglandin-D synthase
-
-
-
-
Prostaglandin-H2 D-isomerase
-
-
-
-
Prostaglandin-R-prostaglandin D isomerase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
isomerization
-
-
-
-
intramolecular oxidoreduction
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -
SYSTEMATIC NAME
IUBMB Comments
(5Z,13E,15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase
Brings about the opening of the epidioxy bridge. Some enzymes require glutathione.
CAS REGISTRY NUMBER
COMMENTARY hide
52227-78-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
show the reaction diagram
-
-
?
1-bromo-2,4-dinitrobenzene + glutathione
?
show the reaction diagram
conjugation of glutathione
-
?
1-chloro-2,4-dinitrobenzene + glutathione
?
show the reaction diagram
conjugation of glutathione
-
?
1-fluoro-2,4-dinitrobenzene + glutathione
?
show the reaction diagram
conjugation of glutathione
-
?
1-iodo-2,4-dinitrobenzene + glutathione
?
show the reaction diagram
conjugation of glutathione
-
?
4-hydroxynon-2-enal + glutathione
?
show the reaction diagram
conjugation of glutathione
-
?
4-nitrobenzyl chloride + glutathione
?
show the reaction diagram
conjugation of glutathione
-
?
7-chloro-4-nitrobenz-2-oxa-1,3-diazole + glutathione
?
show the reaction diagram
conjugation of glutathione
-
?
allyl isothiocyanate + glutathione
?
show the reaction diagram
conjugation of glutathione
-
?
benzyl isothiocyanate + glutathione
?
show the reaction diagram
conjugation of glutathione
-
?
cumene hydroperoxide
cumene hydroxide
show the reaction diagram
-
-
?
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
show the reaction diagram
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
show the reaction diagram
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
glutathione
-
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Cibacron blue
0.00003 mM, 50% inhibition
haematin
0.00008 mM, 50% inhibition
Tributyltin acetate
0.00009 mM, 50% inhibition
tributyltin bromide
0.00003 mM, 50% inhibition
Tributyltin chloride
0.00001 mM, 50% inhibition
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
glutathione
-
brain enzyme is glutathione-independent
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
11.7
pH 8.0, 25°C
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
HPGDS_CHICK
199
0
22730
Swiss-Prot
Mitochondrion (Reliability: 5)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
22732
x * 22732, deduced from nucleotide sequence
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 22732, deduced from nucleotide sequence
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant PGDS
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression of cDNA in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vesin, M.F.; Droz, B.
Immunodetection of prostaglandin D synthase conditions of localization in a defined subclass of primary sensory neurons
J. Histochem. Cytochem.
43
681-687
1995
Gallus gallus
Manually annotated by BRENDA team
Urade, Y.; Watanabe, K.; Hayaishi, O.
Prostaglandin D, E, and F synthases
J. Lipid Mediat. Cell Signal.
12
257-273
1995
Gallus gallus, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Thomson, A.M.; Meyer, D.J.; Hayes, J.D.
Sequence, catalytic properties and expression of chicken glutathione-dependent prostaglandin D2 synthase, a novel class sigma glutathione S-transferase
Biochem. J.
333
317-325
1998
Gallus gallus (O73888)
-
Manually annotated by BRENDA team
Fujimori, K.; Inui, T.; Uodome, N.; Kadoyama, K.; Aritake, K.; Urade, Y.
Zebrafish and chicken lipocalin-type prostaglandin D synthase homologues: Conservation of mammalian gene structure and binding ability for lipophilic molecules, and difference in expression profile and enzyme activity
Gene
375
14-25
2006
Mus musculus, Gallus gallus (Q8QFM7), Gallus gallus, Danio rerio (Q8QGV4), Danio rerio
Manually annotated by BRENDA team