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Information on EC 5.3.99.12 - lachrymatory-factor synthase

for references in articles please use BRENDA:EC5.3.99.12

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IUBMB Comments

The enzyme is responsible for production of the irritating lachrymatory factor that is released by onions and related species when they are chopped. It acts of the product of EC 4.4.1.4, alliin lyase. The enzyme from Allium cepa (onion) acts on (E)-prop-1-en-1-SO-peroxol and produces (Z)-propanethial oxide, while the enzyme from Allium siculum (honey garlic) acts on (E)-but-1-en-1-SO-peroxol and produces (Z)-butanethial oxide.

The enzyme appears in viruses and cellular organisms

Synonyms
lachrymatory factor synthase, lachrymatory-factor synthase, lf synthase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(E)-alk-1-en-1-SO-peroxol = (Z)-alkanethial oxide
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
(Z)-butanethial-S-oxide biosynthesis, propanethial S-oxide biosynthesis
Highest Expressing Human Cell Lines
Cell Line Links Gene Links