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Information on EC 5.3.3.1 - steroid DELTA-isomerase and Organism(s) Rattus norvegicus and UniProt Accession P22071

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EC Tree
     5 Isomerases
         5.3 Intramolecular oxidoreductases
             5.3.3 Transposing C=C bonds
                5.3.3.1 steroid DELTA-isomerase
IUBMB Comments
This activity is catalysed by several distinct enzymes (cf. EC 1.1.3.6, cholesterol oxidase and EC 1.1.1.145, 3-hydroxy-5-steroid dehydrogenase).
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This record set is specific for:
Rattus norvegicus
UNIPROT: P22071
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Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
Synonyms
3beta-hsd, ketosteroid isomerase, delta 5-3-ketosteroid isomerase, steroid isomerase, 3beta-hydroxysteroid dehydrogenase/isomerase, steroid delta-isomerase, gst a3-3, 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase, 3beta-hsd/isomerase, 5-ene-4-ene isomerase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3beta-hydroxysteroid dehydrogenase/5-ene-4-ene isomerase
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3-Keto-DELTA5-steroid isomerase
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3-Ketosteroid DELTA5-->DELTA4-isomerase
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3-Oxo steroid DELTA4-DELTA5-isomerase
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3-Oxo-delta5 steroid isomerase
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3-Oxosteroid DELTA4-DELTA5-isomerase
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3-Oxosteroid DELTA5-DELTA4-isomerase
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3-Oxosteroid isomerase
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5-Ene-4-ene isomerase
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5-Pregnene-3,20-dione isomerase
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delta 5-3-ketosteroid isomerase
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DELTA-3-ketosteroid isomerase
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Delta-5-3-ketosteroid isomerase
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DELTA5(or DELTA4)-3-keto steroid isomerase
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DELTA5-3-keto steroid isomerase
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DELTA5-3-ketosteroid isomerase
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DELTA5-3-oxosteroid isomerase
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DELTA5-ketosteroid isomerase
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DELTA5-steroid isomerase
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Hydroxysteroid isomerase
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Isomerase, steroid DELTA
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Steroid 5-->4-isomerase
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Steroid isomerase
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additional information
cf. EC 1.1.1.51 and EC 1.1.1.145
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
isomerization
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-
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intramolecular oxidoreduction
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SYSTEMATIC NAME
IUBMB Comments
3-oxosteroid DELTA5-DELTA4-isomerase
This activity is catalysed by several distinct enzymes (cf. EC 1.1.3.6, cholesterol oxidase and EC 1.1.1.145, 3-hydroxy-5-steroid dehydrogenase).
CAS REGISTRY NUMBER
COMMENTARY hide
9031-36-1
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
5-Androstene-3-one
?
show the reaction diagram
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?
additional information
?
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bifunctional enzyme possessing 3-beta-hydroxy-DELTA5-steroid dehydrogenase, EC 1.1.1.145, and steroid DELTA-isomerase activity
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?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5'-(4-fluorosulfonylbenzoyl)adenosine
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
additional information
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
enzyme expression analysis in male and pseudopregnant female rat brain, in situ hybridization, overview, strong expression in olfactory bulb, striatum, cortex, thalamus, hypothalamus, septum, habenula, hippocampus and cerebellum, pseudopregnancy has no effect on enzyme expression in brain, effect of lesions, overview
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
3BHS1_RAT
373
0
42037
Swiss-Prot
other Location (Reliability: 5)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
46800
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x * 46800, SDS-PAGE, enzyme with steroid DELTA-isomerase activity and 3beta-hydroxy-5-ene-steroid dehydrogenase activity
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
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x * 46800, SDS-PAGE, enzyme with steroid DELTA-isomerase activity and 3beta-hydroxy-5-ene-steroid dehydrogenase activity
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
the 3beta-hydroxysteroid dehydrogenase cannot be separated from the isomerase
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ishii-Ohba, H.; Inano, H.; Tamaoki, B.
Purification and properties of testicular 3beta-hydroxy-5-ene-steroid dehydrogenase and 5-ene-4-ene isomerase
J. Steroid Biochem.
25
555-560
1986
Rattus norvegicus
Manually annotated by BRENDA team
Soma, K.K.; Sinchak, K.; Lakhter, A.; Schlinger, B.A.; Micevych, P.E.
Neurosteroids and female reproduction: Estrogen increases 3beta-HSD mRNA and activity in rat hypothalamus
Endocrinology
146
4386-4390
2005
Rattus norvegicus (P22071)
Manually annotated by BRENDA team
Meffre, D.; Delespierre, B.; Gouezou, M.; Schumacher, M.; Stein, D.G.; Guennoun, R.
3beta-Hydroxysteroid dehydrogenase/5-ene-4-ene isomerase mRNA expression in rat brain: effect of pseudopregnancy and traumatic brain injury
J. Steroid Biochem. Mol. Biol.
104
293-300
2007
Rattus norvegicus (P22071)
Manually annotated by BRENDA team