Reference on EC 5.3.2.1 - phenylpyruvate tautomerase
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Knox, W.E.; Pitt, B.M.
Enzymic catalysis of the keto-enol tautomerization of phenylpyruvic acids
J. Biol. Chem.
225
675-688
1957
Bos taurus, Canis lupus familiaris, Cavia porcellus, Equus caballus, Neurospora sp., no activity in Aerobacter sp., Oryctolagus cuniculus, Pseudomonas sp., Rattus norvegicus, Sus scrofa
Blasi, F.; Fragomele, F.; Covelli, I.
Thyroidal phenylpyruvate tautomerase
J. Biol. Chem.
244
4864-4870
1969
Sus scrofa
Knox, W.E.
p-Hydroxyphenylpyruvate enol-keto tautomerase
Methods Enzymol.
2
289-292
1955
Sus scrofa
-
Retey, J.; Bartl, K.; Ripp, E.; Hull, W.E.
Stereospecificity of phenylpyruvate tautomerase. A convenient method for the preparation of chirally labelled phenylpyruvates
Eur. J. Biochem.
72
251-257
1977
Bos taurus
Pirrung, M.C.; Chen, J.; Rowley, E.G.; McPhall, A.T.
Mechanistic and stereochemical study of phenylpyruvate tautomerase
J. Am. Chem. Soc.
115
7103-7110
1993
Sus scrofa
-
Rosengarten, E.; Aman, P.; Thelin, S.; Hansson, C.; Ahlfors, S.; Bjoerk, P.; Jacobson, L.; Rorsman, H.
The macrophage inhibitory factor MIF is a phenylpyruvate tautomerase
FEBS Lett.
417
85-88
1997
Bos taurus, Homo sapiens
Hermanowski-Vosatka, A.; Mundt, S.S.; Ayala, J.M.; Goyal, S.; Hanlon, W.A.; Czerwinski, R.M.; Wright, S.D.; Whitman, C.P.
Enzymatically inactive macrophage migration inhibitory factor inhibits monocyte chemotaxis and random migration
Biochemistry
38
12841-12849
1999
Mus musculus
Johnson, W.H., Jr.; Czerwinski, R.M.; Stamps, S.L.; Whitman, C.P.
A kinetic and stereochemical investigation of the role of lysine-32 in the phenylpyruvate tautomerase activity catalyzed by macrophage migration inhibitory factor
Biochemistry
38
16024-16033
1999
Mus musculus
Lubetsky, J.B.; Swope, M.; Dealwis, C.; Blake, P.; Lolis, E.
Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity
Biochemistry
38
7346-7354
1999
Homo sapiens (P14174)
Taylor, A.B.; Johnson, W.H., Jr.; Czerwinski, R.M.; Li, H.S.; Hackert, M.L.; Whitman, C.P.
Crystal structure of macrophage migration inhibitory factor complexed with (E)-2-fluoro-p-hydroxycinnamate at 1.8 A resolution: implications for enzymatic catalysis and inhibition
Biochemistry
38
7444-7452
1999
Mus musculus (P34884), Mus musculus
Stamps, S.L.; Taylor, A.B.; Wang, S.C.; Hackert, M.L.; Whitman, C.P.
Mechanism of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor: properties of the P1G, P1A, Y95F, and N97A mutants
Biochemistry
39
9671-9678
2000
Mus musculus (P34884)
Zang, X.; Taylor, P.; Wang, J.M.; Meyer, D.J.; Scott, A.L.; Walkinshaw, M.D.; Maizels, R.M.
Homologues of human macrophage migration inhibitory factor from a parasitic nematode. Gene cloning, protein activity, and crystal structure
J. Biol. Chem.
277
44261-44267
2002
Brugia malayi (Q9NAS2), Brugia malayi
Molnar, V.; Garai, J.
Plant-derived anti-inflammatory compounds affect MIF tautomerase activity
Int. Immunopharmacol.
5
849-856
2005
Bos taurus
Poelarends, G.J.; Johnson, W.H.; Serrano, H.; Whitman, C.P.
Phenylpyruvate tautomerase activity of trans-3-chloroacrylic acid dehalogenase: evidence for an enol intermediate in the dehalogenase reaction?
Biochemistry
46
9596-9604
2007
Mus musculus, Pseudomonas pavonaceae, Pseudomonas pavonaceae 170
Cherepkova, O.A.; Lyutova, E.M.; Gurvits, B.Y.
Macrophage migration inhibitory factor: isolation from bovine brain
Biochemistry (Moscow)
71
73-78
2006
Bos taurus
Golubkov, P.A.; Johnson, W.H.; Czerwinski, R.M.; Person, M.D.; Wang, S.C.; Whitman, C.P.; Hackert, M.L.
Inactivation of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor by 2-oxo-4-phenyl-3-butynoate
Bioorg. Chem.
34
183-199
2006
Mus musculus (P34884)
Garai, J.; Molnar, V.; Eros, D.; Orfi, L.; Lorand, T.
MIF tautomerase inhibitor potency of alpha,beta-unsaturated cyclic ketones
Int. Immunopharmacol.
7
1741-1746
2007
Bos taurus
Poelarends, G.J.; Veetil, V.P.; Whitman, C.P.
The chemical versatility of the beta-alpha-beta fold: catalytic promiscuity and divergent evolution in the tautomerase superfamily
Cell. Mol. Life Sci.
65
3606-3618
2008
Pseudomonas pavonaceae, Pseudomonas pavonaceae 170
Ouertatani-Sakouhi, H.; El-Turk, F.; Fauvet, B.; Roger, T.; Le Roy, D.; Karpinar, D.P.; Leng, L.; Bucala, R.; Zweckstetter, M.; Calandra, T.; Lashuel, H.A.
A new class of isothiocyanate-based irreversible inhibitors of macrophage migration inhibitory factor
Biochemistry
48
9858-9870
2009
Homo sapiens
Garai, J.; Lorand, T.
Macrophage migration inhibitory factor (MIF) tautomerase inhibitors as potential novel anti-inflammatory agents: current developments
Curr. Med. Chem.
16
1091-1114
2009
Homo sapiens
Baas, B.J.; Zandvoort, E.; Wasiel, A.A.; Quax, W.J.; Poelarends, G.J.
Characterization of a newly identified mycobacterial tautomerase with promiscuous dehalogenase and hydratase activities reveals a functional link to a recently diverged cis-3-chloroacrylic acid dehalogenase
Biochemistry
50
2889-2899
2011
Mycolicibacterium smegmatis, Mycolicibacterium smegmatis mc(2)155
Cho, Y.; Crichlow, G.V.; Vermeire, J.J.; Leng, L.; Du, X.; Hodsdon, M.E.; Bucala, R.; Cappello, M.; Gross, M.; Gaeta, F.; Johnson, K.; Lolis, E.J.
Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast
Proc. Natl. Acad. Sci. USA
107
11313-11318
2010
Homo sapiens
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