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Information on EC 5.3.1.8 - mannose-6-phosphate isomerase and Organism(s) Thermoplasma acidophilum and UniProt Accession Q9HIC2

for references in articles please use BRENDA:EC5.3.1.8
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IUBMB Comments
A zinc protein.
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This record set is specific for:
Thermoplasma acidophilum
UNIPROT: Q9HIC2
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Word Map
The taxonomic range for the selected organisms is: Thermoplasma acidophilum
The enzyme appears in selected viruses and cellular organisms
Synonyms
phosphomannose isomerase, mannose phosphate isomerase, mannose-6-phosphate isomerase, phosphohexoisomerase, phosphomannoisomerase, phosphomannose-isomerase, phosphohexomutase, gtmpi, type i phosphomannose isomerase, type i pmi, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D-mannose-6-phosphate ketol-isomerase
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-
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Isomerase, mannose phosphate
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Mannose phosphate isomerase
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Phosphohexoisomerase
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-
-
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Phosphohexomutase
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-
-
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Phosphomannoisomerase
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-
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Phosphomannose isomerase
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-
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Phosphphexomutase
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-
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PMI
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-
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
isomerization
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intramolecular oxidoreduction
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SYSTEMATIC NAME
IUBMB Comments
D-mannose-6-phosphate aldose-ketose-isomerase
A zinc protein.
CAS REGISTRY NUMBER
COMMENTARY hide
9023-88-5
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-fructose 6-phosphate
D-glucose 6-phosphate
show the reaction diagram
-
-
-
r
D-fructose 6-phosphate
D-mannose 6-phosphate
show the reaction diagram
-
-
-
r
D-glucose 6-phosphate
D-fructose 6-phosphate
show the reaction diagram
-
-
-
r
D-Mannose 6-phosphate
D-Fructose 6-phosphate
show the reaction diagram
-
-
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r
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
6-phosphogluconate
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erythrose 4-phosphate
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.2
D-fructose 6-phosphate
80°C, pH 7.4
0.72
D-glucose 6-phosphate
80°C, pH 7.4
0.25
D-mannose 6-phosphate
80°C, pH 7.4
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2 - 10
6-phosphogluconate
80°C, pH 7.4
0.164
erythrose 4-phosphate
80°C, pH 7.4
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
biunctional phosphoglucose/phosphomannose isomerase EC 5.3.1.9 and 5.3.1.8, resp.
Swissprot
Manually annotated by BRENDA team
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
35000
2 * 35000, SDS-PAGE, 2 * 35150, calculated
35150
2 * 35000, SDS-PAGE, 2 * 35150, calculated
48000
gel filtration
67000
analytical ultracentrifugation
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dimer
2 * 35000, SDS-PAGE, 2 * 35150, calculated
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hansen, T.; Wendorff, D.; Schonheit, P.
Bifunctional phosphoglucose/phosphomannose isomerases from the Archaea Aeropyrum pernix and Thermoplasma acidophilum constitute a novel enzyme family within the phosphoglucose isomerase superfamily
J. Biol. Chem.
279
2262-2272
2004
Aeropyrum pernix (Q9YE01), Thermoplasma acidophilum (Q9HIC2)
Manually annotated by BRENDA team