Information on EC 5.2.1.12 - zeta-carotene isomerase

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The enzyme appears in viruses and cellular organisms

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EC NUMBER
COMMENTARY hide
5.2.1.12
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RECOMMENDED NAME
GeneOntology No.
zeta-carotene isomerase
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
9,15,9'-tricis-zeta-carotene = 9,9'-dicis-zeta-carotene
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
trans-lycopene biosynthesis II (oxygenic phototrophs and green sulfur bacteria)
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carotenoid biosynthesis
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Carotenoid biosynthesis
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Metabolic pathways
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Biosynthesis of secondary metabolites
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SYSTEMATIC NAME
IUBMB Comments
9,15,9'-tricis-zeta-carotene cis-trans-isomerase
The enzyme catalyses the cis-trans isomerization of the 15-15' carbon-carbon double bond in 9,15,9'-tricis-zeta-carotene, which is required for biosynthesis of all plant carotenoids. Requires heme b.
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
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in absence of light, the 9,15,9'-tri-cis-zeta-carotene isomer accumulates in etiolated leaves and roots of maize plants carrying the recessive y9 allele in comparison to normal carotenoid composition in light-exposed y9 leaves
physiological function
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
9,15,9'-tricis-zeta-carotene
9,9'-dicis-zeta-carotene
show the reaction diagram
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
9,15,9'-tricis-zeta-carotene
9,9'-dicis-zeta-carotene
show the reaction diagram
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
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LINKS TO OTHER DATABASES (specific for EC-Number 5.2.1.12)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)