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Information on EC 5.1.99.4 - alpha-methylacyl-CoA racemase and Organism(s) Mus musculus and UniProt Accession O09174

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EC Tree
     5 Isomerases
         5.1 Racemases and epimerases
             5.1.99 Acting on other compounds
                5.1.99.4 alpha-methylacyl-CoA racemase
IUBMB Comments
alpha-methyl-branched acyl-CoA derivatives with chain lengths of more than C10 are substrates. Also active towards some aromatic compounds (e.g. ibuprofen) and bile acid intermediates, such as trihydroxycoprostanoyl-CoA. Not active towards free acids
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This record set is specific for:
Mus musculus
UNIPROT: O09174
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
amacr, p504s, alpha-methylacyl-coa racemase, alpha-methylacyl-coenzyme a racemase, alpha-methylacyl coenzyme a racemase, alpha-methylacyl coa racemase, amacr/p504s, 2-methylacyl-coa racemase, alpha-methyl coa racemase, 2-arylpropionyl-coa epimerase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
2-arylpropionyl-CoA epimerase
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-
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2-methylacyl-CoA racemase
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-
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alpha-Methylacyl CoA racemase
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GenBank U89905-derived protein GI2145184
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GenBank U89906-derived protein GI 2145186
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Racemase, alpha-methylacyl coenzyme A
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Racemase, alpha-methylacyl coenzyme A (Mus musculus clone 3)
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Racemase, alpha-methylacyl coenzyme A (Rattus norvegicus clone 11)
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
racemization
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PATHWAY SOURCE
PATHWAYS
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-, -, -
SYSTEMATIC NAME
IUBMB Comments
2-Methylacyl-CoA 2-epimerase
alpha-methyl-branched acyl-CoA derivatives with chain lengths of more than C10 are substrates. Also active towards some aromatic compounds (e.g. ibuprofen) and bile acid intermediates, such as trihydroxycoprostanoyl-CoA. Not active towards free acids
CAS REGISTRY NUMBER
COMMENTARY hide
156681-44-6
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197731-71-8
racemase, alpha-methylacyl coenzyme A (Mus musculus clone 3) /genBank U89906-derived protein GI 2145186
197731-72-9
racemase, alpha-methylacyl coenzyme A (Rattus norvegicus clone 11) /genBank U89905-derived protein GI2145184
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
Uniprot
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
knockout mouse models deficient in AMACR or MFE-2 (peroxisomal multifunctional enzyme type 2), in which this beta-oxidation pathway is prevented, display a residual C24-bile acid pool which, although greatly reduced, implies the existence of alternative pathways of bile acid synthesis. The total bile acid pool is decreased in Mfe-1-/- mice compared with wild-type and the levels of mature C24-bile acids are reduced in the double knockout mice when compared with AMACR-deficient mice
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
AMACR_MOUSE
381
0
41704
Swiss-Prot
other Location (Reliability: 4)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schmitz, W.; Helander, H.M.; Hiltunen, J.K.; Conzelmann, E.
Molecular cloning of cDNA species for rat and mouse liver alpha-methylacyl-CoA racemase
Biochem. J.
326
883-889
1997
Mus musculus (O09174), Mus musculus, Rattus norvegicus (P70473)
Manually annotated by BRENDA team
Autio, K.J.; Schmitz, W.; Nair, R.R.; Selkaelae, E.M.; Sormunen, R.T.; Miinalainen, I.J.; Crick, P.J.; Wang, Y.; Griffiths, W.J.; Reddy, J.K.; Baes, M.; Hiltunen, J.K.
Role of AMACR (aloha-methylacyl-CoA racemase) and MFE-1 (peroxisomal multifunctional enzyme-1) in bile acid synthesis in mice
Biochem. J.
461
125-135
2014
Mus musculus (O09174), Mus musculus, Mus musculus C57BL/6 (O09174)
Manually annotated by BRENDA team