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EC Tree
IUBMB Comments Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose. This enzyme catalyses the first step in galactose metabolism by converting beta-D-galactose into alpha-D-galactose, which is the substrate for EC 2.7.1.6, galactokinase [5,6].
The taxonomic range for the selected organisms is: Homo sapiens The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
mutarotase, galactose mutarotase, aldose 1-epimerase, aldose-1-epimerase, styead, aldose-l-epimerase, galactomutarotase, aldose mutarotase,
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aldose mutarotase
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Epimerase, aldose-1
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alpha-D-glucose = beta-D-glucose
E307 and H176 may act as catalytic acid and catalytic base, respectively
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Aldose 1-epimerase
Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose. This enzyme catalyses the first step in galactose metabolism by converting beta-D-galactose into alpha-D-galactose, which is the substrate for EC 2.7.1.6, galactokinase [5,6].
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alpha-D-galactose
beta-D-galactose
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r
alpha-D-glucose
beta-D-glucose
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r
alpha-D-glucose
beta-D-glucose
additional information
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alpha-D-glucose
beta-D-glucose
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alpha-D-glucose
beta-D-glucose
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additional information
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key enzyme of carbohydrate metabolism catalysing the interconversion of the alpha-anomer and beta-anomer of hexose sugars such as glucose and galactose
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additional information
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key enzyme of carbohydrate metabolism catalysing the interconversion of the alpha-anomer and beta-anomer of hexose sugars such as glucose and galactose
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additional information
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additional information
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key enzyme of carbohydrate metabolism catalysing the interconversion of the alpha-anomer and beta-anomer of hexose sugars such as glucose and galactose
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additional information
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key enzyme of carbohydrate metabolism catalysing the interconversion of the alpha-anomer and beta-anomer of hexose sugars such as glucose and galactose
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?
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Carcinoma
[Quantitative and comparative proteomics analysis in clear cell renal cell carcinoma and adjacent noncancerous tissues by 2-D DIGE].
Carcinoma, Renal Cell
[Quantitative and comparative proteomics analysis in clear cell renal cell carcinoma and adjacent noncancerous tissues by 2-D DIGE].
Dysentery
Entamoeba histolytica: molecular characterization of an aldose 1-epimerase (mutarotase).
Nephrotic Syndrome
Mutarotase activity in serum and urine of rat with experimental nephrotic syndrome.
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37
alpha-D-galactose
pH 8.0, 20°C
54
alpha-D-glucose
pH 8.0, 20°C
12
alpha-D-glucose
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kidney
19
alpha-D-glucose
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alpha-D-glucose, liver
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12000
alpha-D-galactose
pH 8.0, 20°C
4900
alpha-D-glucose
pH 8.0, 20°C
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Uniprot
brenda
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brenda
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brenda
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GALM_HUMAN
342
0
37766
Swiss-Prot
other Location (Reliability: 3 )
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37500
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liver and kidney, sucrose density gradient centrifugation
additional information
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enzyme undergoes a molecular transition to a more compact form
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both apoform and in complex with beta-D-galactose, comparison with enzyme from Lactococcus lactis and Caenorhabditis elegans
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E307A
mutant enzyme without aldose 1-epimerase activity
H107A
mutant enzyme with 5fold reduced activity with alpha-D-galactose and 7.8fold reduced activity with alpha-D-glucose, compared to wild-type enzyme
H176A
mutant enzyme without aldose 1-epimerase activity
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expression in Escherichia coli
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Mulhern, S.A.; Fishman, P.H.; Kusiak, J.W.; Bailey, J.M.
Physical characteristics and chemi-osmotic transformations of mutarotases from various species
J. Biol. Chem.
248
4163-4173
1973
Batrachoididae gen. sp., Bos taurus, Canis lupus familiaris, Capsicum frutescens, Catfish, Cavia porcellus, Escherichia coli, Gallus gallus, Homo sapiens, Lithobates catesbeianus, Meriones unguiculatus, Mus musculus, Mushroom, Oryctolagus cuniculus, Ovis aries, Perca flavescens, Sus scrofa
brenda
Bailey, J.M.; Fishman, P.H.; Kusiak, J.W.; Mulhern, S.; Pentchev, P.G.
Mutarotase (aldose 1-epimerase) from kidney cortex
Methods Enzymol.
41
471-484
1975
Bos taurus, Capsicum frutescens, Catfish, Escherichia coli, Gallus gallus, Homo sapiens, Lithobates catesbeianus, Mushroom, Oryctolagus cuniculus, Ovis aries
brenda
Timson, D.J.; Reece, R.J.
Identification and characterisation of human aldose 1-epimerase
FEBS Lett.
543
21-24
2003
Homo sapiens (Q96C23), Homo sapiens
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Thoden, J.B.; Timson, D.J.; Reece, R.J.; Holden, H.M.
Molecular structure of human galactose mutarotase
J. Biol. Chem.
279
23431-23437
2004
Homo sapiens
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