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Information on EC 5.1.3.19 - chondroitin-glucuronate 5-epimerase and Organism(s) Mus musculus and UniProt Accession Q8BLI4

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EC Tree
IUBMB Comments
Not identical with EC 5.1.3.17 heparosan-N-sulfate-glucuronate 5-epimerase.
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This record set is specific for:
Mus musculus
UNIPROT: Q8BLI4
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
ds-epi1, ds-epi2, sart2, dermatan sulfate epimerase, chondroitin-glucuronate c5-epimerase, ds-epimerase 1, dermatan sulfate epimerase 1, chondroitin-glucuronate 5-epimerase, ds epimerase 1, chondroitin d-glucuronosyl 5-epimerase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dermatan sulfate epimerase 1
-
DS epimerase 1
-
DS-epi1
isoform
Chondroitin D-glucuronosyl 5-epimerase
-
-
-
-
dermatan sulfate epimerase 1
-
-
dermatan sulfate epimerase 2
-
Dermatan-sulfate 5-epimerase
-
-
-
-
DS epimerase 2
-
DS-epi1
-
-
DS-epi2
Epimerase, chondroitin glucuronate 5-
-
-
-
-
Polyglucuronate 5-epimerase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
epimerization
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
chondroitin-D-glucuronate 5-epimerase
Not identical with EC 5.1.3.17 heparosan-N-sulfate-glucuronate 5-epimerase.
CAS REGISTRY NUMBER
COMMENTARY hide
70766-66-4
-
86417-91-6
identical to EC 6.2.1.26
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
D-glucuronate
L-iduronate
show the reaction diagram
-
-
-
?
D-glucuronate
L-iduronate
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
D-glucuronate
L-iduronate
show the reaction diagram
-
-
-
?
D-glucuronate
L-iduronate
show the reaction diagram
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.5
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
isoform DS-epi1 (Dse)
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
additional information
-
expression levels of wild-type, heterozygous and homozygous enzyme mutants, overview
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
-
DS-epi1 deficiency alters skin morphology, collagen fibril ultrastructure, and skin tensile strength, phenotype, overview
physiological function
isoform DS-epi2 plays key roles in the epimerization of chondroitin sulfate and dermatan sulfate during its biosynthesis. The L-iduronate-containing structures in the developing brain are mainly produced by the actions of isoform DS-epi2 and play crucial roles in postnatal development
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DSE_MOUSE
958
3
109755
Swiss-Prot
Secretory Pathway (Reliability: 1)
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
generation of DS-epi1-null mice, the mutant mice show alterations in the chondroitin/dermatan polysaccharide chains. The numbers of long blocks of adjacent iduronic acids are greatly decreased in skin decorin and biglycan chondroitin/dermatan sulfate, along with a parallel decrease in iduronic-2-O-sulfated-galactosamine-4-O-sulfated structures. Both iduronic acid blocks and iduronic acids surrounded by glucuronic acids are also decreased in versican-derived chains. DS-epi1-deficient mice are smaller than their wild-type littermates but otherwise have no gross macroscopic alterations, DS-epi1-null fibrils have a larger diameter than the wild-type fibrils, phenotypes, overview
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Maccarana, M.; Kalamajski, S.; Kongsgaard, M.; Magnusson, S.P.; Oldberg, A.; Malmstroem, A.
Dermatan sulfate epimerase 1-deficient mice have reduced content and changed distribution of iduronic acids in dermatan sulfate and an altered collagen structure in skin
Mol. Cell. Biol.
29
5517-5528
2009
Mus musculus
Manually annotated by BRENDA team
Akatsu, C.; Mizumoto, S.; Kaneiwa, T.; Maccarana, M.; Malmstroem, A.; Yamada, S.; Sugahara, K.
Dermatan sulfate epimerase 2 is the predominant isozyme in the formation of the chondroitin sulfate/dermatan sulfate hybrid structure in postnatal developing mouse brain
Glycobiology
21
565-574
2011
Mus musculus (Q0VBN2), Mus musculus (Q8BLI4), Mus musculus
Manually annotated by BRENDA team