Information on EC 5.1.3.10 - CDP-paratose 2-epimerase

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EC Tree 5 Isomerases 5.1 Racemases and epimerases 5.1.3 Acting on carbohydrates and derivatives 5.1.3.10 CDP-paratose 2-epimerase

IUBMB Comments

Requires NAD⁺.

The expected taxonomic range for this enzyme is: Bacteria, Archaea

5.1.3.10
prolyl
peptidyl-prolyl
phosphorylation-dependent
peptidyl
single-domain
beta-strands
parvulins
heteronuclear
ppiases
triple-stranded

Reaction Schemes

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CDP-alpha-D-paratose

CDP-alpha-D-tyvelose

Synonyms
CDP abequose epimerase, CDP paratose epimerase, CDP-abequose 2-epimerase, CDP-abequose epimerase, CDP-D-abequose 2-epimerase, CDPabequose 2-epimerase, Cytidine diphosphate paratose-2-epimerase, Cytidine diphosphoabequose epimerase, Cytidine diphosphodideoxyglucose epimerase, Cytidine diphosphoparatose epimerase, more

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

CDP abequose epimerase

CDP paratose epimerase

CDP-abequose 2-epimerase

CDP-abequose epimerase

CDP-D-abequose 2-epimerase

CDPabequose 2-epimerase

Cytidine diphosphate paratose-2-epimerase

Cytidine diphosphoabequose epimerase

Cytidine diphosphodideoxyglucose epimerase

Cytidine diphosphoparatose epimerase

Epimerase, cytidine diphosphoabequose

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

CDP-alpha-D-paratose = CDP-alpha-D-tyvelose

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REACTION TYPE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

epimerization

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Go to Pathway Search

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PATHWAY SOURCE

PATHWAYS

KEGG

Amino sugar and nucleotide sugar metabolism, O-Antigen nucleotide sugar biosynthesis

MetaCyc

CDP-tyvelose biosynthesis

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Go to Systematic Name Search

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SYSTEMATIC NAME

IUBMB Comments

CDP-3,6-dideoxy-D-glucose 2-epimerase

Requires NAD+.

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CAS REGISTRY NUMBER

COMMENTARY

37318-36-8

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

Reversibility
r=reversible
ir=irreversible
?=not specified

CDP-3,6-dideoxy-D-glucose

CDP-3,6-dideoxy-D-mannose

3 entries

additional information

Salmonella durban

2245

Substrates: biosynthesis of CDP-dideoxyhexoses. The specific O-antigen factors of group A and D1 Salmonella i.e. O-2 and O-9 factors, are related to 3,6-dideoxy-D-glucose and 3,6-dideoxy-D-mannose respectively
Products: -

CDP-3,6-dideoxy-D-glucose

CDP-3,6-dideoxy-D-mannose

Salmonella durban

2245

Substrates: -
Products: -

CDP-3,6-dideoxy-D-glucose

CDP-3,6-dideoxy-D-mannose

Salmonella enterica subsp. enterica serovar Enteritidis

2246

Substrates: r
Products: -

CDP-3,6-dideoxy-D-glucose

CDP-3,6-dideoxy-D-mannose

Yersinia pseudotuberculosis

2247

Substrates: -
Products: -

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

LITERATURE

COMMENTARY

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

additional information

Salmonella durban

2245

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COFACTOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

NAD+

Salmonella enterica subsp. enterica serovar Enteritidis

stimulates, Km: 0.001 mM

2246

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.085

CDP-3,6-dideoxy-D-glucose

Salmonella enterica subsp. enterica serovar Enteritidis

2246

0.052

CDP-3,6-dideoxy-D-mannose

Salmonella enterica subsp. enterica serovar Enteritidis

2246

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SPECIFIC ACTIVITY [µmol/min/mg]

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

0.025

Salmonella enterica subsp. enterica serovar Enteritidis

2246

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pH OPTIMUM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

8 - 9

Salmonella enterica subsp. enterica serovar Enteritidis

2246

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

7 - 11.8

Salmonella enterica subsp. enterica serovar Enteritidis

7.0: about 35% of maximal activity, 11.8: about 40% of maximal activity

2246

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only manually annotated data include textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks include all textmining data from AMENDAenzyme occurrence in organism, localization and source tissue with reliability ranks + FRENDAco-occurrence of enzyme names and organism names (less precise)

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Salmonella durban

mutant strains defective in CDP-D-abequose 2-epimerase activity

2245

brenda

Salmonella enterica subsp. enterica serovar Enteritidis

2246

brenda

Yersinia pseudotuberculosis

2247

brenda

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PURIFICATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

Salmonella enterica subsp. enterica serovar Enteritidis

2246

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

2245

Sasaki, T.; Uchida, T.

Mutants of group D1 Salmonella carrying the somatic antigen of group A organisms: evidence for the lack of cytidine diphosphate paratose-2-epimerase activity

J. Bacteriol.

117

13-18

1974

Salmonella durban

4808896

brenda

2246

Matsuhashi, S.

Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. II. Reversible 2-epimerization of cytidine diphosphate paratose

J. Biol. Chem.

241

4275-4282

1966

Salmonella enterica subsp. enterica serovar Enteritidis

5924649

brenda

2247

Matsuhashi, S.; Strominger, J.L.

Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses

J. Biol. Chem.

242

3494-3500

1967

Yersinia pseudotuberculosis

brenda

Entries 1 - 20 of 3

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EXTERNAL LINKS (specific for EC-Number 5.1.3.10)

ExplorEnz (official portal for IUBMB Enzyme Nomenclature)

Expasy Enzyme Nomenclature Database

KEGG

SABIO-RK

NCBI: PubMed, Protein, Nucleotide, Structure, Gene, OMIM

Enzyme Nomenclature (alternative site)

UniProt

PDB

PROSITE Database of protein families and domains

InterPro (database of protein families, domains and functional sites)

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