Reference on EC 5.1.1.4 - proline racemase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Stadtman, T.C.; Elliott, P.
Studies on the enzymic reduction of amino acids. II. Purification and properties of a D-proline reductase and a proline racemase from Clostridium sticklandii
J. Biol. Chem.
228
983-997
1957
Acetoanaerobium sticklandii
Manually annotated by BRENDA team
Cardinale, G.J.; Abeles, R.H.
Purification and mechanism of action of proline racemase
Biochemistry
7
3970-3978
1968
Acetoanaerobium sticklandii
Manually annotated by BRENDA team
Keenan, M.V.; Alworth, W.L.
The inhibition of proline racemase by a transition state analogue: DELTA-1-pyrroline-2-carboxylate
Biochem. Biophys. Res. Commun.
57
500-504
1974
Acetoanaerobium sticklandii
Manually annotated by BRENDA team
Rudnick, G.; Abeles, R.H.
Reaction mechanism and structure of the active site of proline racemase
Biochemistry
14
4515-4522
1975
Acetoanaerobium sticklandii
Manually annotated by BRENDA team
Fisher, L.M.; Albery, W.J.; Knowles, J.R.
Energetics of proline racemase: racemization of unlabeled proline in the unsaturated, saturated and oversaturated regimes
Biochemistry
25
2529-2537
1986
Acetoanaerobium sticklandii
Manually annotated by BRENDA team
Fisher, L.M.; Belasco, J.G.; Bruice, T.W.; Albery, W.J.; Knowles, J.R.
Energetics of proline racemase: transition-state fractionation factors for the two protons involved in the catalytic steps
Biochemistry
25
2543-2551
1986
Acetoanaerobium sticklandii
Manually annotated by BRENDA team
Belasco, J.G.; Bruice, T.W.; Fisher, L.M.; Albery, W.J.; Knowles, J.R.
Energetics of proline racemase: rates, fractionation factors, and buffer catalysis in the oversaturated region. Nature of the interconversion of the two forms of free enzyme
Biochemistry
25
2564-2571
1986
Acetoanaerobium sticklandii
Manually annotated by BRENDA team
Fisher, L.M.; Albery, W.J.; Knowles, J.R.
Energetics of proline racemase: tracer perturbation experiments using [14C]proline that measure the interconversion rate of the two forms of free enzyme
Biochemistry
25
2538-2542
1986
Acetoanaerobium sticklandii
Manually annotated by BRENDA team
Belasco, J.G.; Bruice, T.W.; Albery, W.J.; Knowles, J.R.
Energetics of proline racemase: fractionation factors for the essential catalytic groups in the enzyme-substrate complexes
Biochemistry
25
2558-2564
1986
Acetoanaerobium sticklandii
Manually annotated by BRENDA team
Albery, W.J.; Knowles, J.R.
Energetics and mechanism of proline racemase
Biochemistry
25
2572-2577
1986
Acetoanaerobium sticklandii
Manually annotated by BRENDA team
Belasco, J.G.; Albery, W.J.; Knowles, J.R.
Energetics of proline racemase: double fractionation experiment, a test for concertedness and for transition-state dominance
Biochemistry
25
2552-2558
1986
Acetoanaerobium sticklandii
Manually annotated by BRENDA team
Chamond, N.; Gregoire, C.; Coatnoan, N.; Rougeot, C.; Freitas-Junior, L.H.; da Silveira, J.F.; Degrave, W.M.; Minoprio, P.
Biochemical characterization of proline racemases from the human protozoan parasite Trypanosoma cruzi and definition of putative protein signatures
J. Biol. Chem.
278
15484-15494
2003
Trypanosoma cruzi (Q4DA80), Trypanosoma cruzi (Q868H8), Trypanosoma cruzi
Manually annotated by BRENDA team
Reina-San-Martin, B.; Degrave, W.; Rougeot, C.; Cosson, A.; Chamond, N.; Cordeiro-Da-Silva, A.; Arala-Chaves, M.; Coutinho, A.; Minoprio, P.
A B-cell mitogen from a pathogenic trypanosome is a eukaryotic proline racemase
Nat. Med.
6
890-897
2000
Trypanosoma cruzi (Q4DA80), Trypanosoma cruzi
Manually annotated by BRENDA team
Chamond, N.; Goytia, M.; Coatnoan, N.; Barale, J.C.; Cosson, A.; Degrave, W.M.; Minoprio, P.
Trypanosoma cruzi proline racemases are involved in parasite differentiation and infectivity
Mol. Microbiol.
58
46-60
2005
Trypanosoma cruzi (Q4DA80), Trypanosoma cruzi
Manually annotated by BRENDA team
Stenta, M.; Calvaresi, M.; Altoe, P.; Spinelli, D.; Garavelli, M.; Bottoni, A.
The Catalytic Activity of Proline Racemase: A Quantum Mechanical/Molecular Mechanical Study
J. Phys. Chem. B
112
1057-1059
2008
Trypanosoma cruzi (Q4DA80), Trypanosoma cruzi
Manually annotated by BRENDA team
Goytia, M.; Chamond, N.; Cosson, A.; Coatnoan, N.; Hermant, D.; Berneman, A.; Minoprio, P.
Molecular and structural discrimination of proline racemase and hydroxyproline-2-epimerase from nosocomial and bacterial pathogens
PLoS ONE
2
e885
2007
Clostridioides difficile (A8DEZ8), Clostridioides difficile VPI10463 (A8DEZ8)
Manually annotated by BRENDA team
Buschiazzo, A.; Goytia, M.; Schaeffer, F.; Degrave, W.; Shepard, W.; Gregoire, C.; Chamond, N.; Cosson, A.; Berneman, A.; Coatnoan, N.; Alzari, P.M.; Minoprio, P.
Crystal structure, catalytic mechanism, and mitogenic properties of Trypanosoma cruzi proline racemase
Proc. Natl. Acad. Sci. USA
103
1705-1710
2006
Trypanosoma cruzi (Q4DA80), Trypanosoma cruzi
Manually annotated by BRENDA team
Rubinstein, A.; Major, D.T.
Catalyzing racemizations in the absence of a cofactor: the reaction mechanism in proline racemase
J. Am. Chem. Soc.
131
8513-8521
2009
Trypanosoma cruzi
Manually annotated by BRENDA team
Fonknechten, N.; Perret, A.; Perchat, N.; Tricot, S.; Lechaplais, C.; Vallenet, D.; Vergne, C.; Zaparucha, A.; Le Paslier, D.; Weissenbach, J.; Salanoubat, M.
A conserved gene cluster rules anaerobic oxidative degradation of L-ornithine
J. Bacteriol.
191
3162-3167
2009
Acetoanaerobium sticklandii (Q9L4Q3)
Manually annotated by BRENDA team
Coutinho, L.; Ferreira, M.A.; Cosson, A.; Batista, M.M.; Batista, D.d.a..G.; Minoprio, P.; Degrave, W.M.; Berneman, A.; Soeiro Mde, N.
Inhibition of Trypanosoma cruzi proline racemase affects host-parasite interactions and the outcome of in vitro infection
Mem. Inst. Oswaldo Cruz
104
1055-1062
2009
Trypanosoma cruzi
Manually annotated by BRENDA team
Coatnoan, N.; Berneman, A.; Chamond, N.; Minoprio, P.
Proline racemases: Insights into Trypanosoma cruzi peptides containing D-proline
Mem. Inst. Oswaldo Cruz
104
295-300
2009
Trypanosoma cruzi (Q4D480), Trypanosoma cruzi (Q868H8), Trypanosoma cruzi
Manually annotated by BRENDA team
Chamond, N.; Cosson, A.; Coatnoan, N.; Minoprio, P.
Proline racemases are conserved mitogens: characterization of a Trypanosoma vivax proline racemase
Mol. Biochem. Parasitol.
165
170-179
2009
Trypanosoma vivax (B8LFE4), Trypanosoma vivax
Manually annotated by BRENDA team
Bryan, M.; Norris, K.
Genetic immunization converts the Trypanosoma cruzi B-cell mitogen proline racemase to an effective immunogen
Infect. Immun.
78
810-822
2010
Trypanosoma cruzi, Trypanosoma cruzi Y
Manually annotated by BRENDA team
Harty, M.; Nagar, M.; Atkinson, L.; Legay, C.M.; Derksen, D.J.; Bearne, S.L.
Inhibition of serine and proline racemases by substrate-product analogues
Bioorg. Med. Chem. Lett.
24
390-393
2014
Acetoanaerobium sticklandii
Manually annotated by BRENDA team
Wu, X.; Hurdle, J.G.
The Clostridium difficile proline racemase is not essential for early logarithmic growth and infection
Can. J. Microbiol.
60
251-254
2014
Clostridioides difficile
Manually annotated by BRENDA team
Berneman, A.; Montout, L.; Goyard, S.; Chamond, N.; Cosson, A.; dArchivio, S.; Gouault, N.; Uriac, P.; Blondel, A.; Minoprio, P.
Combined approaches for drug design points the way to novel proline racemase inhibitor candidates to fight Chagas disease
PLoS ONE
8
e60955
2013
Trypanosoma cruzi
Manually annotated by BRENDA team
Watanabe, S.; Tanimoto, Y.; Nishiwaki, H.; Watanabe, Y.
Identification and characterization of bifunctional proline racemase/hydroxyproline epimerase from archaea: discrimination of substrates and molecular evolution
PLoS One
10
e0120349
2015
Clostridioides difficile (Q17ZY4), Ferroplasma acidarmanus (S0APF4), Haloarcula japonica (M0LMI3), Haloarcula japonica DSM 6131 (M0LMI3), Thermococcus litoralis (H3ZMH5), Thermococcus litoralis, Thermococcus litoralis DSM 5473 (H3ZMH5)
Manually annotated by BRENDA team
Caballero, Z.C.; Costa-Martins, A.G.; Ferreira, R.C.; P Alves, J.M.; Serrano, M.G.; Camargo, E.P.; Buck, G.A.; Minoprio, P.; G Teixeira, M.M.
Phylogenetic and syntenic data support a single horizontal transference to a Trypanosoma ancestor of a prokaryotic proline racemase implicated in parasite evasion from host defences
Parasit. Vectors
8
222
2015
no activity in Trypanosoma brucei, no activity in Trypanosoma congolense, Trypanosoma conorhini (A0A0F6YF18), Trypanosoma conorhini, Trypanosoma conorhini TCC025 (A0A0F6YF18), Trypanosoma cruzi (Q4DA80), Trypanosoma cruzi (Q868H8), Trypanosoma cruzi, Trypanosoma cruzi CL Brener (Q4DA80), Trypanosoma cruzi CL Brener (Q868H8), Trypanosoma cruzi marinkellei (A0A0F6VXD6), Trypanosoma cruzi marinkellei TCC344 (A0A0F6VXD6), Trypanosoma dionisii, Trypanosoma dionisii TCC211, Trypanosoma erneyi (A0A0F6VXE2), Trypanosoma erneyi TCC1946 (A0A0F6VXE2), Trypanosoma grayi, Trypanosoma grayi ANR4, Trypanosoma lewisi (A0A0F6VXM2), Trypanosoma lewisi, Trypanosoma lewisi TCC034 (A0A0F6VXM2), Trypanosoma rangeli, Trypanosoma serpentis (A0A0F6SCP6), Trypanosoma serpentis TCC1052 (A0A0F6SCP6), Trypanosoma sp. (A0A0F6VXD9), Trypanosoma sp. TCC1825 / RCF-2014 (A0A0F6VXD9), Trypanosoma sp. TCC339 (A0A0F6YER1), Trypanosoma sp. TCC878 (A0A0F6VXE6), Trypanosoma sp. TCC878 RCF-2014 (A0A0F6VXE6), Trypanosoma vivax (B8LFE4), Trypanosoma vivax, Trypanosoma vivax Y486 (B8LFE4)
Manually annotated by BRENDA team
Fikru, R.; Hagos, A.; Roge, S.; Reyna-Bello, A.; Gonzatti, M.I.; Merga, B.; Goddeeris, B.M.; Buescher, P.
A proline racemase based PCR for identification of Trypanosoma vivax in cattle blood
PLoS ONE
9
e84819
2014
Trypanosoma vivax (B8LFE4), Trypanosoma vivax, Trypanosoma vivax ILRAD 1392 (B8LFE4)
Manually annotated by BRENDA team